American journal of veterinary research最新文献

{"title":"Glycyrrhizin alleviated cisplatin-induced testicular injury by inhibiting the oxidative, apoptotic, hormonal, and histological alterations.","authors":"Fawiziah Khalaf Alharbi, Lashin Saad Ali, Gamal A Salem, Naira ElAshmouny, Sanad S El-Kholy, Walaa M Essawi, Azza I Helal, Hany Sabry A Ibrahim, Naief Dahran, Eman S El-Shetry, Rania Hassan Mohamed Soliman, Hassan Emam, Mamdouh Eldesoqui, Fahmy Gad Elsaid, Fawziah A Al-Salmi, Doaa Abdelrahaman, Eman Fayad, Abdel-Rahman A Sobeih, Wael A M Ghonimi","doi":"10.2460/ajvr.24.10.0288","DOIUrl":"10.2460/ajvr.24.10.0288","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the potential contribution of glycyrrhizin (GLZ) to mitigate the testicular toxicity linked to cisplatin (CIS) intoxication.</p><p><strong>Methods: </strong>40 mature male Wistar albino rats (Rattus norvegicus albinus) were randomly divided into 4 equal groups (n = 10) for 60 days: the control group, CIS-treated group (single dose of 7 mg/kg, IP), GLZ-treated group (25 mg/kg, PO), and GLZ plus CIS-treated group. Blood and testis samples were examined using biochemical, histological, and immunohistochemical techniques. Semen samples were also obtained, and any abnormalities were reported.</p><p><strong>Results: </strong>Serum follicle-stimulating hormone, luteinizing hormone, and testosterone levels were all markedly reduced by CIS. Oxidative stress and a significant reduction in levels of the antioxidant enzymes glutathione peroxidase, superoxide dismutase, and catalase were linked to CIS. Immunohistochemically, CIS showed diffuse, significantly positive immunolocalizations against the anti-caspase 3 antibody, indicating widespread apoptosis within the testicular parenchyma. Histopathologically, CIS showed diffuse coagulative necrosis of spermatogenic cells, necrotic Sertoli cells, intertubular edema, and Leydig cell hyperplasia. Moreover, CIS revealed a noteworthy increase in sperm abnormalities. Pre-coadministration and posttreatment with GLZ mitigated the majority of these detrimental consequences, and serum levels of antioxidant enzymes, luteinizing hormone, follicle-stimulating hormone, and testosterone were significantly elevated.</p><p><strong>Conclusions: </strong>Glycyrrhizin has been proven to be a strong antioxidant as well as antiapoptotic and cytoprotective against CIS testicular damage.</p><p><strong>Clinical relevance: </strong>The described model is a tool to evaluate the testicular protective impact of GLZ.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The EpiCentre: redefining the future of animal health.","authors":"Naomi Cogger, Emilie Vallee, Supatsak Subharat, Masako Wada, Masood Sujau, Jun-Hee Han, Katja E Isaksen, Chris W R Compton","doi":"10.2460/ajvr.24.10.0298","DOIUrl":"10.2460/ajvr.24.10.0298","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of production practices and sanitary management on the prevalence of Neospora caninum and bluetongue virus in Creole goats from the tropical dry forest of Utcubamba, Peru.","authors":"Lucinda Tafur Gutiérrez, Gudelio Alva, David J Godoy, Hugo Frías, Miguel A Arista, William Bardales, Ricardo Encina, Segundo M Portocarrero, José A Saucedo, Juancarlos A Cruz, Nilton L Murga","doi":"10.2460/ajvr.24.08.0238","DOIUrl":"10.2460/ajvr.24.08.0238","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to report the impact of production practices and sanitary management on the prevalence of Neospora caninum (N caninum) and bluetongue virus (BTV) in Creole goats from the tropical dry forest of Utcubamba, Peru.</p><p><strong>Methods: </strong>354 blood samples were obtained from male and female goats of diverse ages reared under an extensive productive system. The diagnosis of N caninum and BTV was conducted through a commercial ELISA kit (iD.vet) with readings taken on a Bio-Rad iMark microplate reader at 450 nm. Additionally, a survey was conducted with 18 goat producers to categorize them based on social, technical (production, health, reproduction, nutrition, and infrastructure), environmental, and economic factors.</p><p><strong>Results: </strong>The overall seroprevalence of N caninum and BTV in goats was 6.21% and 7.06%, respectively, Notably, group II farmers had the highest prevalence rates at 7.69% for N caninum and 23.08% for BTV. This group comprises producers with fewer than 21 goats, while group III includes 14.3% of producers with over 60 goats and better infrastructure.</p><p><strong>Conclusions: </strong>This study confirms the presence of N caninum and BTV in goats of Utcubamba, Peru. Group II displayed the highest prevalence rates, suggesting that herd size and management infrastructure influence disease prevalence.</p><p><strong>Clinical relevance: </strong>In the tropical dry forest of Utcubamba, inadequate management of N caninum carrier agents (eg, nondewormed dogs) heightens transmission risk, while the tropical climate supports BTV vectors. Effective diagnosis and health management strategies, including vector control and biosecurity practices, are crucial for ongoing herd health monitoring.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Domestic ferrets (Mustela putorius furo) with cholecystitis commonly show hyperbilirubinemia and common bile duct dilation, gallbladder sludge, and gallbladder wall thickening on ultrasound.","authors":"Catherine Veciana Basse, Yannick Ruel, Albert Agoulon, Hugues Gaillot","doi":"10.2460/ajvr.24.07.0191","DOIUrl":"10.2460/ajvr.24.07.0191","url":null,"abstract":"<p><strong>Objective: </strong>To report clinical signs, biological anomalies, treatment, and outcome in domestic ferrets with cholecystitis, describe the ultrasonographic features of cholecystitis, and compare the ultrasonographic appearance of the hepatobiliary system between diseased and healthy ferrets.</p><p><strong>Methods: </strong>11 ferrets with confirmed cholecystitis and abdominal ultrasonography were retrospectively included. Ten healthy ferrets were prospectively recruited to undergo hepatobiliary abdominal ultrasonography. Comparisons of explanatory variables (group, age, body weight, and sex) were performed.</p><p><strong>Results: </strong>The most common clinical signs were nonspecific, and icterus was observed in 1/4 of diseased ferrets. Compared with healthy individuals, diseased ferrets showed a larger common bile duct (CBD; ≥ 2.8 mm), a thicker CBD wall (≥ 0.7 mm), a thicker gallbladder (GB) wall, more frequent echoic GB luminal content, visible intrahepatic bile ducts, and a greater GB volume. Bile culture was positive in 9/11 mostly for Escherichia coli (8/9). Bile cytology indicated septic purulent cholecystitis in 7/7 ferrets. Survival time after antibiotic treatment ranged from 6 to 104 weeks, with a median of 36 weeks.</p><p><strong>Conclusions: </strong>Ferrets with cholecystitis presented with nonspecific clinical signs and frequently showed hyperbilirubinemia. Ultrasonography findings such as enlarged CBD, thickened CBD wall, thicker GB wall, GB sludge, visible intrahepatic bile ducts, and enlarged GB may suggest cholecystitis. Escherichia coli was commonly isolated from bile. The medium-term mortality rate was high despite targeted antibiotherapy.</p><p><strong>Clinical relevance: </strong>This is the first study describing the clinical signs, biological anomalies, ultrasonographic findings, and outcomes after treatment in a series of domestic ferrets with cholecystitis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-care viscoelastic coagulation monitoring device shows promise for informing resuscitation strategies in a canine hemorrhagic shock model.","authors":"Taylor N Baird, Kristin M Zersen, Julien Guillaumin","doi":"10.2460/ajvr.24.07.0196","DOIUrl":"10.2460/ajvr.24.07.0196","url":null,"abstract":"<p><strong>Objective: </strong>To use a point-of-care viscoelastic coagulation monitoring device (VCM-Vet; Entegrion) and traditional tests to assess hemostatic changes during hemorrhagic shock in dogs.</p><p><strong>Methods: </strong>8 healthy, purpose-bred Beagles were enrolled in a hemorrhagic shock model conducted from September through December 2021. Dogs were anesthetized, had baseline hemostatic variables measured after blood pressure was stabilized at 70 to 80 mm Hg for 10 minutes (T1), had blood withdrawn from a jugular vein to achieve a mean blood pressure of 40 ± 5 mm Hg for 10 minutes (T2), were resuscitated with 100% shed blood, and then had hemostatic variables evaluated 10 minutes later (T3). At each time point, hemostatic variables were measured with traditional tests (Hct, WBC count, platelet count, mean platelet volume, prothrombin time, activated partial thromboplastin time [aPTT], and concentrations of fibrinogen, antithrombin, and D-dimer) and the VCM-Vet device (clot time, clot formation time, α-angle, maximum clot formation, amplitude at 10 minutes [A10], amplitude at 20 minutes [A20], clot lysis index at 30 minutes [LI30], and clot lysis index at 45 minutes [LI45]).</p><p><strong>Results: </strong>All dogs survived without complication. At T2 and T3 (vs T1), samples had significantly higher coagulability (increased median α-angle, A10, and A20) and fibrinolysis (decreased median LI30 and LI45) and significantly longer aPTT; however, all values remained within reference limits.</p><p><strong>Conclusions: </strong>The use of VCM-Vet helped identify complex hemostatic disturbances in dogs with hemorrhagic shock.</p><p><strong>Clinical relevance: </strong>The use of VCM-Vet shows promise in aiding veterinarians in optimizing resuscitation strategies based on real-time clotting data.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the fecal microbiome of healthy rabbits (Oryctolagus cuniculus domesticus) compared with rabbits with gastrointestinal disease using next-generation DNA sequencing.","authors":"Gina Vecere, Shachar Malka, Nicole Sands, Margaret Lee, Janina A Krumbeck","doi":"10.2460/ajvr.24.07.0193","DOIUrl":"10.2460/ajvr.24.07.0193","url":null,"abstract":"<p><strong>Objective: </strong>To determine the normal fecal microbiome of healthy rabbits in comparison to rabbits with gastrointestinal (GI) disease. Next-generation DNA sequencing was used to identify the primary bacteria and fungi in the microbiome.</p><p><strong>Methods: </strong>Fecal pellets from 25 clinically healthy rabbits and 25 rabbits experiencing GI disease were collected. Next-generation DNA sequencing was performed targeting the ITS-2 region for mycobiome, and the V1-V3 region of the 16S rRNA for bacteriome analysis. ITS-2 stands for internal transcribed spacer 2, a region of DNA in fungi that is used to identify and classify species.</p><p><strong>Results: </strong>In healthy rabbit feces, Bacteroidales sp, Odoribacter sp, Paraprevotella xylaniphila, Lachnospiraceae sp, Papillibacter sp, Akkermansia sp, and Ruminococcus sp were noted to be more prevalent. Comparatively, Lachnoclostridium sp, Anaerotruncus sp, Subdoligranulum sp, and B uniformis were found in greater abundance in rabbits with GI disease. Only 1 fungal species, Malassezia restricta, was significantly enriched in the GI disease group.</p><p><strong>Conclusions: </strong>Next-generation DNA sequencing technology can be used to evaluate the microbiome of the rabbit GI tract through fecal material and can provide a clinically accessible testing method for veterinarians.</p><p><strong>Clinical relevance: </strong>Numerous bacteria and fungi in the fecal samples of healthy rabbits were identified that could be considered markers of gastrointestinal health; similarly, specific bacteria and fungi were noted in greater abundance in rabbits with GI disease, which should be further investigated for their importance in causing, contributing to, or as the result of clinical disease. These findings support the use of next-generation DNA sequencing in order to diversify our understanding of the microbiome of rabbit feces, aid in clinical diagnosis, and provide support for the need for more specific probiotic supplements for rabbits.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Livestock-associated methicillin-resistant Staphylococcus aureus ST398 causing severe mastitis in a meat sheep herd in the United States.","authors":"Guilherme S Moura, Mauro M S Saraiva, Danilo T Stipp, Wondwossen A Gebreyes, Celso J B Oliveira","doi":"10.2460/ajvr.24.05.0137","DOIUrl":"10.2460/ajvr.24.05.0137","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of differentially expressed genes related to cell death in porcine kidney-15 cells at 24 and 48 hours post porcine parvovirus infection.","authors":"Tingting Lu, Xinghui Song, Li Zhao, Xia Ma","doi":"10.2460/ajvr.24.06.0164","DOIUrl":"10.2460/ajvr.24.06.0164","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to identify and characterize differentially expressed genes (DEGs) associated with porcine parvovirus (PPV)-induced cell death in porcine kidney-15 (PK-15) cells. By analyzing the biological processes enriched by these DEGs and exploring their interaction networks, we aim to gain a deeper understanding of the molecular mechanisms underlying PPV-mediated cell death.</p><p><strong>Methods: </strong>After infecting cultured PK-15 cells with PPV for 24 and 48 hours, cell viability and cysteine-requiring aspartate protease-3 (caspase-3) activity were assessed using an enzyme marker. Apoptosis was observed using fluorescence microscopy. The genome-wide gene expression levels were analyzed through RNA sequencing. The functional enrichment of DEGs was analyzed using the Kyoto Encyclopedia of Genes and Genomes database, and the protein-protein interaction network was generated using the Search Tool for the Retrieval of Interacting Genes/Proteins database.</p><p><strong>Results: </strong>Porcine parvovirus inhibits cell viability, boosts caspase-3 activity, and enhances cell death at 24 and 48 hours postinfection (HPI). Porcine parvovirus-infected cells showed 547 DEGs at 24 HPI and 1,765 at 48 HPI. Different forms of cell death were enriched in 149 genes that were upregulated at both 24 and 48 HPI. More DEGs associated with cell death were involved at 48 than at 24 HPI. These DEGs are involved in multiple signaling pathways and interact within a complex protein network.</p><p><strong>Conclusions: </strong>Porcine parvovirus infection of PK-15 cells induces multiple cell death-related DEGs and signaling pathways.</p><p><strong>Clinical relevance: </strong>Our study presents a promising approach to investigating the mechanism of PPV infection, with a particular focus on the induction of cell death.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dogs with diet-associated dilated cardiomyopathy have higher urine di-docosahexaenoyl (22:6)-bis(monoacylglycerol)phosphate, a biomarker of phospholipidosis.","authors":"Lisa M Freeman, John E Rush, Brian R Berridge, Richard N Mitchell, Esther Gisela Martinez-Romero","doi":"10.2460/ajvr.24.07.0211","DOIUrl":"10.2460/ajvr.24.07.0211","url":null,"abstract":"<p><strong>Objective: </strong>In dogs with diet-associated dilated cardiomyopathy (DCM), we have identified electron microscopic changes suggestive of abnormal lysosomal accumulation of phospholipids and consistent with the appearance of drug-induced phospholipidosis in people and other animals. The objective of this study was to compare concentrations of urine di-docosahexaenoyl (22:6)-bis(monoacylglycerol)phosphate (BMP), a biomarker of drug-induced phospholipidosis, in dogs with DCM eating high-pulse (HP) diets, dogs with DCM eating low-pulse (LP) diets, and healthy controls (control-HP and control-LP).</p><p><strong>Methods: </strong>In this cross-sectional study, voided urine was collected from client-owned dogs with DCM from September 2018 through March 2020. Urine di-22:6-BMP was measured by LC-MS-MS and normalized to urine creatinine. Normalized di-22:6-BMP concentrations were compared among groups using mixed-effects-model analysis.</p><p><strong>Results: </strong>53 dogs were included: DCM-HP (n = 25), DCM-LP (n = 4), control-HP (n = 10), and control-LP (n = 14). Mixed-effects models adjusted for age and sex showed that HP diet was significantly associated with higher normalized urine di-22:6-BMP concentrations. A 1-way ANOVA identified a significant difference among the 4 groups, with Tukey post hoc analysis showing that the DCM-HP group had significantly higher normalized urine di-22:6-BMP concentrations compared to the control-LP group. Normalized di-22:6-BMP concentrations were significantly positively correlated with diet pulse scores (r = 0.52).</p><p><strong>Conclusions: </strong>High-pulse diets were significantly associated with higher normalized urine di-22:6-BMP concentrations.</p><p><strong>Clinical relevance: </strong>These results support the possible presence of primary or secondary phospholipidosis in dogs with diet-associated DCM and provide a plausible mechanism for further investigation.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical comparison of four isometric prosthetic ligament repair techniques for tarsal medial collateral ligament injury.","authors":"Sidney Chanutin, Matthew D Johnson, C J Travers, Mitchell S Gillick, James Colee, Scott A Banks","doi":"10.2460/ajvr.24.06.0165","DOIUrl":"10.2460/ajvr.24.06.0165","url":null,"abstract":"<p><strong>Objective: </strong>To compare the stability, ultimate strength, and isometry of 4 prosthetic ligament repairs for canine tarsal medial collateral ligament injury.</p><p><strong>Methods: </strong>24 cadaveric canine distal hind limbs with induced medial tarsal instability were randomly divided into 4 groups. Simulated medial shearing injury of the collateral and medial malleolus were repaired using 1 of 4 isometric suture techniques: bone tunnels with nylon suture (TN), ultrahigh-molecular-weight polyethylene (UHMWPE) suture (TU), tibial bone anchor with nylon suture (AN), or talar bone anchor with UHMWPE suture (AU). Each repair was evaluated for medial stability before and after cyclic range of motion. 3 of 4 repair configurations allowed string potentiometer isometry data collection during cyclic range of motion. Each construct was subsequently tested to failure; the strength and failure mode were recorded.</p><p><strong>Results: </strong>All repair groups showed statistically increased laxity compared to intact ligament. There was no difference in joint laxity between repair techniques. Cyclic range-of-motion testing did not increase joint laxity at any tested joint angle. Strength to failure was no different between repair groups. Isometry was achieved in the TU and TN groups.</p><p><strong>Conclusions: </strong>All 4 techniques improved medial stability compared to that medial collateral ligament injury; however, no technique returned stability to the tarsal of the intact ligament. All 4 techniques maintained stability after range-of-motion testing. Isometric placement of the prosthetic suture was achievable. The constructs did not provide sufficient resistance to physiologic valgus stress.</p><p><strong>Clinical relevance: </strong>Isometric placement of a prosthetic ligament is possible; secondary stabilization appears necessary to support the repair postoperatively.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142520749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}