{"title":"Letters to the Editor.","authors":"Jan F Hawkins","doi":"10.2460/ajvr.87.03.letter-editorial","DOIUrl":"https://doi.org/10.2460/ajvr.87.03.letter-editorial","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":"87 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jamie S F Lemus, Barbara Delvescovo, Elizabeth Williams Louie, Stephen Parry, Stephanie A Hon, Marta Cercone, Rebecca C McOnie
{"title":"Evaluation of a point-of-care device for creatinine measurement in nonazotemic pigs presented to a referral hospital.","authors":"Jamie S F Lemus, Barbara Delvescovo, Elizabeth Williams Louie, Stephen Parry, Stephanie A Hon, Marta Cercone, Rebecca C McOnie","doi":"10.2460/ajvr.25.10.0367","DOIUrl":"10.2460/ajvr.25.10.0367","url":null,"abstract":"<p><strong>Objective: </strong>To compare creatinine concentrations measured using a point-of-care unit (Nova StatSensor; NSS) to those from a comparison method (CM) chemistry analyzer from pigs presented at a referral institution.</p><p><strong>Methods: </strong>A clinical prospective study was performed including 61 pigs admitted to Cornell Nemo Farm Animal Hospital for clinical reasons. Heparinized blood samples were obtained by venous aspiration, and whole-blood samples were obtained via ear prick. Creatinine concentrations were subsequently measured in triplicate on the NSS (on heparinized venous samples [NSSven] and ear prick samples [NSSear]) and compared to the CM. Paired t tests and intraclass correlation coefficients were performed. A Bland-Altman plot was graphed based on a linear mixed-effects model to estimate agreement between tests. Equivalence testing was performed.</p><p><strong>Results: </strong>NSSven (n = 110) and NSSear (71) from 61 nonazotemic pigs were analyzed. The mean creatinine ± SD was 1.3 ± 0.52 mg/dL from the CM, 1.1 ± 0.43 mg/dL from the NSSven, and 1.2 ± 0.42 mg/dL from the NSSear. Bias existed between average NSSven (-0.17 mg/dL) and NSSear (-0.21 mg/dL) and the CM. The 95% CI of the limit of agreement between the NSSven and CM was -0.88 to 0.54 and -1.04 to 0.62 between the NSSear and CM. The tests were not equivalent at 0.3 mg/dL.</p><p><strong>Conclusions: </strong>The NSSven, NSSear, and CM results are different and not equivalent in nonazotemic pigs.</p><p><strong>Clinical relevance: </strong>The use of this device for screening of creatinine in pigs is discouraged based on the results in this population.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saskia Herges, Hannah Ohrem, René Dörfelt, Florian Sänger
{"title":"Hematological changes after intermittent hemodialysis in dogs with acute kidney injury are mild and transient.","authors":"Saskia Herges, Hannah Ohrem, René Dörfelt, Florian Sänger","doi":"10.2460/ajvr.25.12.0458","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0458","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate hematological changes in dogs with acute kidney injury caused by different underlying disease processes treated with intermittent hemodialysis (IHD) over 12 to 24 hours after the session.</p><p><strong>Methods: </strong>Client-owned dogs with acute kidney injury treated with IHD from February 2021 through July 2025 were prospectively enrolled in this observational study. Blood was collected from each dog before IHD (T0), after IHD (T1), and 12 to 24 hours after IHD (T2). Hematocrit, RBC count, hemoglobin concentration, reticulocyte count, platelet count, and WBC count were evaluated at all time points.</p><p><strong>Results: </strong>In total, 30 dogs with 82 IHD sessions were included in the study. Median RBC count (X 1012/L) and median hemoglobin concentration (mmol/L) decreased from 4.00 (2.82 to 7.22) and 9.25 (6.60 to 17.20) at T0 to 3.74 (2.39 to 7.04) and 9.00 (5.50 to 16.80) at T1, respectively. Median WBC count (X 109/L) of 19.34 (6.49 to 55.47) at T0 decreased to 17.6 (4.57 to 73.22) at T1 and increased to 20.11 (7.48 to 55.47) at T2. Median platelet count (X 109/L) of 99 (5 to 767) at T0 decreased to 69 (1 to 633) at T1 and increased to 84 (4 to 604) at T2.</p><p><strong>Conclusions: </strong>Hematological changes during IHD were mild and transient. Only the platelet count decreased moderately.</p><p><strong>Clinical relevance: </strong>Most of the hematological changes did not appear clinically relevant and resolved within 24 hours. However, the moderate decrease in platelet count could potentially predispose dogs undergoing IHD to an increased risk of bleeding.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne L Hendrikx, Johannes C Vendrig, Ronette Gehring, Robin van den Boom, Jennifer van Alphen, Johannes C M Vernooij, Erik Teske, Ellen Roelfsema
{"title":"Repeated intravenous dexamethasone administration causes transient changes in leukocyte parameters in healthy warmblood horses.","authors":"Anne L Hendrikx, Johannes C Vendrig, Ronette Gehring, Robin van den Boom, Jennifer van Alphen, Johannes C M Vernooij, Erik Teske, Ellen Roelfsema","doi":"10.2460/ajvr.25.10.0371","DOIUrl":"https://doi.org/10.2460/ajvr.25.10.0371","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of repeated IV administration of dexamethasone (0.06 mg/kg, q 24 h, twice) on WBC parameters in healthy adult horses.</p><p><strong>Methods: </strong>This prospective, longitudinal study was conducted from October 7 through November 5, 2024. Five warmblood mares received an IV dexamethasone sodium phosphate injection (DMI) at 0 and 24 hours and an IV injection with 0.9% sodium chloride solution at 48 and 72 hours. Blood samples were collected at 0, 6, 12, 24, 30, 36, 48, 72, 96, and 168 hours, and WBC parameters were evaluated using linear mixed-effects models.</p><p><strong>Results: </strong>Leukocyte count, neutrophil count, and neutrophil-to-lymphocyte ratio were increased at 6 hours after DMI. Mean leukocyte count peaked 6 hours after DMI and exceeded the reference interval; however, not all horses had peaks above the reference interval. Neutrophilia was observed in all horses, with peak values 6 hours after DMI. Lymphocyte, monocyte, and eosinophil counts were decreased at 6 hours after DMI, with complete suppression of eosinophils. Myeloperoxidase index was increased only at 6 hours after the second DMI. Neut-X was decreased at 12 hours after DMI, and Neut-Y did not change up to 156 hours after the first DMI. Most parameters returned to baseline at 48 to 72 hours.</p><p><strong>Conclusions: </strong>Repeated IV dexamethasone administration induces recognizable changes in leukograms in healthy horses with transient neutrophilia combined with increased leukocyte counts and neutrophil-to-lymphocyte ratios and decreased lymphocyte, monocyte, and eosinophil counts.</p><p><strong>Clinical relevance: </strong>Recognition of glucocorticoid-induced changes is important for accurate interpretation of hematologic findings in horses receiving glucocorticoids.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Launch of veterinary service-learning series.","authors":"Lisa A Fortier","doi":"10.2460/ajvr.87.03.editorial","DOIUrl":"10.2460/ajvr.87.03.editorial","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":"87 3","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole J Buote, Marije Risselada, Michele A Steffey, Valery Scharf, Helia Zamprogno, Alexandra Winter, Dominique Griffon
{"title":"The coronavirus disease 2019 pandemic increased caseload and stress in veterinary surgeons, but positive changes to working environments did occur.","authors":"Nicole J Buote, Marije Risselada, Michele A Steffey, Valery Scharf, Helia Zamprogno, Alexandra Winter, Dominique Griffon","doi":"10.2460/ajvr.25.11.0391","DOIUrl":"10.2460/ajvr.25.11.0391","url":null,"abstract":"<p><strong>Objective: </strong>To report the changes in veterinary surgeon schedules, workflow, and job satisfaction associated with the COVID-19 pandemic from 2020 through 2021.</p><p><strong>Methods: </strong>A voluntary, nonincentivized, anonymized 40-question internet survey was deployed from November 2021 through February 2022. Veterinary surgeons were surveyed regarding schedule alterations and support implemented by their employers during the pandemic as well as changes in their job satisfaction. Associations between demographics and responses were analyzed.</p><p><strong>Results: </strong>333 respondents, including veterinary surgeons and residents, participated. Most respondents worked in private clinical practice (211 of 320 [65.9%]), followed by academia (95 of 313 [30.3%]). The pandemic significantly affected the work schedule of 245 of 333 respondents (77%), especially those in private practice and influenced by employment position, such as staff surgeon versus owner. 185 of 245 surgeons (76%) reported a stressful work environment, and 244 of 320 (78%) reported an increased caseload. 244 of 320 respondents (76%) felt management responses were supportive of employees; however, only 195 of 314 surgeons (62%) believed their safety was prioritized. While overall job satisfaction decreased from prepandemic levels, 147 of 247 respondents (60%) reported that at least 1 positive change in their work environment occurred due to coronavirus disease 2019 protocols, including the introduction of curbside care and remote meetings.</p><p><strong>Conclusions: </strong>The pandemic affected the working conditions of veterinary surgeons, increasing caseloads and stress. Respondents generally felt supported by their employers who implemented positive changes.</p><p><strong>Clinical relevance: </strong>Work environment strategies identified as positive should be embraced as workplace stress and higher caseloads have impacted job satisfaction in veterinary surgery.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoe Y S Chan, Winnie Ho, Anetta Slobodova, Rebecca S V Parkes, Bronte Forbes, Thilo Pfau
{"title":"Hoof and movement asymmetry in Thoroughbred racehorses with predominantly single direction training.","authors":"Zoe Y S Chan, Winnie Ho, Anetta Slobodova, Rebecca S V Parkes, Bronte Forbes, Thilo Pfau","doi":"10.2460/ajvr.25.12.0437","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0437","url":null,"abstract":"<p><strong>Objective: </strong>To investigate associations between contralateral (left-right) hoof width asymmetry and vertical movement asymmetry in racing Thoroughbreds. We hypothesized that forehoof differences would be associated with poll and withers movement asymmetry and hind hoof differences with pelvis movement asymmetry.</p><p><strong>Methods: </strong>This observational cross-sectional study included 169 Thoroughbred racehorses recently retired from clockwise racing and assessed the day of scheduled farriery work. Contralateral hoof width differences were quantified and movement asymmetry during trot measured using inertial sensors placed on the poll, withers, and pelvis. A primary outcome was the difference in upward movement amplitude between the left and right stance phases (upDiff). Based on measured contralateral hoof width differences, horses were categorized post hoc by the side of the wider hoof, and between-group differences in movement asymmetry were quantified using effect sizes (Cohen d).</p><p><strong>Results: </strong>70% of horses had wider right forehooves and 65% wider right hind hooves. Forehoof width asymmetry was associated with differences in upDiff at the poll (Cohen d = 0.82) and withers (Cohen d = 0.73), with greater vertical displacement during stance of wider hoof. Hind hoof width asymmetry was not associated with pelvic upDiff but at the poll (Cohen d = 0.57) and withers (Cohen d = 0.60).</p><p><strong>Conclusions: </strong>Forelimb hoof width asymmetry was associated with poll and withers movement asymmetry, whereas hind hoof width asymmetry was not associated with pelvic movement asymmetry.</p><p><strong>Clinical relevance: </strong>Assessment of forehoof width asymmetry may aid interpretation of head and withers movement asymmetry during lameness evaluation and inform hoof care and training management in racehorses.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kathia Feliciano Nieves, Jared A Jaffey, Eric T Hostnik, Andrew S Hanzlicek, Corey Mills, Kyle Frankenberger
{"title":"Polymerase chain reaction may not be useful to detect Coccidioides spp DNA in oropharyngeal, nasal, or conjunctival swab samples in dogs with newly diagnosed pulmonary coccidioidomycosis.","authors":"Kathia Feliciano Nieves, Jared A Jaffey, Eric T Hostnik, Andrew S Hanzlicek, Corey Mills, Kyle Frankenberger","doi":"10.2460/ajvr.25.10.0356","DOIUrl":"https://doi.org/10.2460/ajvr.25.10.0356","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic sensitivity of real-time PCR to detect Coccidioides spp DNA from oropharyngeal, nasal cavity, and conjunctival swab samples in dogs with pulmonary coccidioidomycosis.</p><p><strong>Methods: </strong>This was a prospective cohort study of client-owned dogs with newly diagnosed pulmonary coccidioidomycosis from January 2024 to October 2024. Sterile cotton swabs were gently rubbed within the nasal cavity and against the mucosa of the oropharynx and conjunctiva during the initial investigation for respiratory tract signs. Swabs were tested for Coccidioides spp, Blastomyces spp, Histoplasma spp, Pneumocystis jirovecii, and Pneumocystis canis DNA by multiplex quantitative PCR. Antibody serology assays (ie, agar gel immunodiffusion and enzyme immunoassay) were performed at a single reference diagnostic laboratory.</p><p><strong>Results: </strong>24 dogs were included. Seventy-two PCR tests (nasal cavity, n = 24; oropharyngeal, 24; and conjunctival, 24) were performed, and none of the tests positively detected Coccidioides spp DNA. Forty-six percent (11 of 24) and 71% (17 of 24) of dogs had positive detection of anti-Coccidioides spp immunoglobulin M and G antibodies with agar gel immunodiffusion, respectively. Seventy-nine percent (19 of 24) of dogs had positive detection of immunoglobulin G antibodies with enzyme immunoassay. Respiratory tract signs improved (50%; n = 12) or completely resolved (42%; 10) after approximately 3 months of PO fluconazole administration.</p><p><strong>Conclusions: </strong>Coccidioides spp DNA was not detected in any swab sample from the upper respiratory tract.</p><p><strong>Clinical relevance: </strong>Quantitative PCR to detect Coccidioides spp DNA from the nasal cavity, oropharynx, and conjunctiva using sterile cotton swabs provides no added diagnostic value in dogs with pulmonary coccidioidomycosis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yookyeong Lee, Sang-Kun Jang, Jaewon Do, Min-Young Kim, Sangyul Lee, Jung Mun Kim, Hwi-Yool Kim
{"title":"Tricortical pin tension-band wiring provides the greatest tensile resistance among fixation constructs for feline greater trochanteric avulsion fractures.","authors":"Yookyeong Lee, Sang-Kun Jang, Jaewon Do, Min-Young Kim, Sangyul Lee, Jung Mun Kim, Hwi-Yool Kim","doi":"10.2460/ajvr.25.11.0415","DOIUrl":"10.2460/ajvr.25.11.0415","url":null,"abstract":"<p><strong>Objective: </strong>To compare the tensile performance of 3 constructs for feline greater trochanter (GT) avulsion fractures using a cadaveric model.</p><p><strong>Methods: </strong>An experimental cadaveric study was performed using a standardized GT osteotomy model. Adult feline cadavers euthanized for reasons unrelated to this study and without radiographic evidence of orthopedic disease were included; specimens with musculoskeletal abnormalities were excluded. All testing was conducted at a single academic biomechanics laboratory. Fixation constructs were subjected to quasistatic tensile loading until failure.</p><p><strong>Results: </strong>18 hindlimbs from 9 feline cadavers were allocated equally to bicortical pin tension-band wiring (TBW; n = 6), tricortical pin TBW (6), and FiberWire-only fixation (6). At 3-mm displacement, tricortical fixation demonstrated higher mean load resistance than both bicortical fixation (mean difference, 45.0 N; 95% CI, 19.7 to 70.3 N) and FiberWire-only fixation (mean difference, 140.5 N; 95% CI, 115.1 to 165.9 N). Bicortical and tricortical constructs exhibited similar resistance at 1- and 2-mm displacement.</p><p><strong>Conclusions: </strong>Tricortical pin TBW provided the greatest tensile resistance under maximal loading. However, the bicortical pin TBW and tricortical pin TBW techniques provided similar strength during early displacement. The FiberWire-only fixation construct demonstrated the lowest stability, suggesting that FiberWire fixation alone may not provide sufficient strength or an optimal tension-band configuration for feline GT avulsion repair.</p><p><strong>Clinical relevance: </strong>For routine feline GT avulsion fracture repair, bicortical pin TBW may offer a practical balance of strength and simplicity. Tricortical pin TBW fixation may be reserved for cases requiring maximal resistance, whereas FiberWire-only fixation should be used with caution due to its lower load-bearing capacity.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hengyan Wang, Tong Liu, Huasong Bai, Hongchen Jin, Zhanzhong Wang
{"title":"Three natural extracts alleviate ovalbumin-induced oxidative stress, inflammation, and barrier dysfunction in canine intestinal epithelial cells.","authors":"Hengyan Wang, Tong Liu, Huasong Bai, Hongchen Jin, Zhanzhong Wang","doi":"10.2460/ajvr.25.09.0349","DOIUrl":"10.2460/ajvr.25.09.0349","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the protective effects of Hydrocotyle asiatica extract (HAE), aloe polysaccharide (AP), and Ginkgo biloba extract (GBE) against ovalbumin (OVA)-induced damage in canine intestinal epithelial cells and to elucidate the underlying mechanisms using a multiomics approach.</p><p><strong>Methods: </strong>The study was conducted from January 1 through September 30, 2025. An in vitro model of OVA-induced injury in canine intestinal epithelial cells was established. The effects of the 3 extracts were assessed through integrated metabolomic and transcriptomic analyses.</p><p><strong>Results: </strong>All 3 extracts (HAE, 320 µg/mL; AP, 1 µg/mL; GBE, 1 µg/mL) significantly mitigated OVA-induced damage: they restored antioxidant activity (eg, superoxide dismutase increased 105% to 137%), suppressed inflammation (eg, tumor necrosis factor-α reduced by up to 25%), and enhanced barrier protein expression. Multiomics analysis specifically linked HAE to the restoration of metabolic pathways (eg, riboflavin metabolism, oxidative phosphorylation) and the upregulation of genes involved in epithelial adhesion and junction assembly.</p><p><strong>Conclusions: </strong>HAE, AP, and GBE exert protective effects against OVA-induced intestinal epithelial cell injury by mitigating oxidative stress, inflammation, and barrier dysfunction. Hydrocotyle asiatica extract specifically modulates key metabolic and transcriptional pathways involved in intestinal integrity.</p><p><strong>Clinical relevance: </strong>These findings provide valuable insights into the mechanisms by which HAE preserves intestinal barrier function and underscore its potential application in enhancing intestinal barrier integrity, which may be relevant for managing food allergies and intestinal inflammatory disorders in clinical settings.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}