Heather L Simmons, Julie Stowell-Moss, Jeremiah T Saliki, Amy K Swinford, Jonathan Rushton, Ashley Railey, Barbara Martin, Terry Hensley, Kaitlin Thompson, Shridula Hegde
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引用次数: 0
Abstract
Objective: Foreign animal diseases (FADs) are nonnative to the US and threaten animal welfare and economy. During FAD outbreaks, reliance solely on laboratory-based tests challenges response due to cost and turnaround time. Validated point-of-care (POC) diagnostic tests enable early field detection, reduce economic impact, and protect animal welfare. This proposal recommends a national POC diagnostic testing framework for FADs, providing guidance on modifying existing tests and serving as a resource for laboratory diagnosticians.
Methods: In 2022, at the American Association of Veterinary Laboratory Diagnosticians annual meeting, the National Animal Health Laboratory Network (NAHLN) Laboratory Directors Committee evaluated a draft POC testing process. In 2023, 27 stakeholders, including regulatory agencies, industry stakeholders, and diagnostic laboratories from 8 states, evaluated the draft process for distribution, use, and reporting and provided recommendations for validating POC testing.
Results: The 6 steps of the POC testing framework were validated by 27 stakeholders. Recommendations for improving FAD response were submitted to the USDA APHIS Veterinary Services and NAHLN, focusing on validation, importation, licensing, test validity, deployment, communication of results, animal movement, and indemnity.
Conclusions: Through stakeholder evaluation of testing framework, recommendations were provided to the USDA APHIS Veterinary Services and NAHLN for validating each step of POC testing framework, thereby reducing detection and response times during FAD outbreaks while making it cost efficient for producers and public. However, test performance and human behavior should be thoroughly evaluated to reduce variability of results.
Clinical relevance: Point-of-care testing to enable quick and cost-effective FAD response, rapid containment, reduced disease transmission, and improved efficiency motivated the development of a stakeholder-informed revision to the testing framework through qualitative evaluation and expert recommendations.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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