American journal of veterinary research最新文献

{"title":"A novel approach to nasopharyngoscopy in canine and feline cadavers: development and application of 3-dimensional-printed instrument guides.","authors":"Miruna Munteanu, Brian Hardy","doi":"10.2460/ajvr.25.01.0005","DOIUrl":"10.2460/ajvr.25.01.0005","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate the use of 3-D-printed instrument guides for nasopharyngoscopy, focusing on maneuverability, the ability to biopsy the nasal choanae, and foreign body retrieval.</p><p><strong>Methods: </strong>Various sizes of 3-D-printed guides (small, medium, large) and angles (160°, 170°, 175°, and 180°) were tested alongside retroflex nasopharyngoscopy in cadavers. Four cadavers representing different sizes and species (3 canines and 1 feline) were utilized to evaluate the success of the 3-D-printed instrument guides. The study evaluated the maneuverability of each guide within the nasopharynx, along with their effectiveness in facilitating choanal biopsies and retrieving a simulated grass foreign body. Performance was compared across guides to determine the most effective design.</p><p><strong>Results: </strong>The 180° guide had limited maneuverability and was unable to facilitate biopsies or foreign body retrieval. The 175° guide showed moderate maneuverability and successfully performed biopsies and foreign body removal, although with mild resistance to movement. The 170° guide demonstrated high maneuverability, enabling smooth access in all directions and consistent procedural success. The 160° guide exhibited the greatest flexibility and procedural success, providing superior maneuverability and ease of use.</p><p><strong>Conclusions: </strong>Three-dimensional-printed instrument guides with more acute angles improve nasopharyngeal access and procedural efficiency. The 160° guide showed the greatest potential for clinical application in facilitating biopsies and foreign body removal.</p><p><strong>Clinical relevance: </strong>Three-dimensional-printed nasopharyngoscopy guides enhance diagnostic and therapeutic procedures by improving access, biopsy collection, and foreign body retrieval. More acute angles offer greater maneuverability, supporting their clinical use for minimally invasive nasopharyngeal interventions in veterinary medicine.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salmonella environmental persistence informs management relevant to avian and public health.","authors":"Kimberly M Perez, Sonia M Hernandez, Olivia Sieverts, William A Norfolk, Raquel Francisco, Nikki W Shariat, Jared C Smith, Jason Locklin, Susan Sanchez, Erin K Lipp, Michael J Yabsley","doi":"10.2460/ajvr.24.12.0397","DOIUrl":"10.2460/ajvr.24.12.0397","url":null,"abstract":"<p><p>Salmonellosis is a significant public health threat responsible for millions of human cases annually but is also of significance to domestic and wild animals around the globe. While human infections are often foodborne, an increasing number of cases arise from environmental sources and contact with animals, including wild birds. Understanding the persistence of Salmonella in shared environments is critical for mitigating zoonotic transmission risks and understanding transmission dynamics for pets and free-living wildlife. Two experiments were conducted to investigate Salmonella persistence on surfaces relevant to wild bird-people interactions. One was a controlled experiment to compare the persistence of an avian-derived Salmonella Typhimurium isolate on bird feeders made of different materials. A total of 9 (7%) swabs were culture positive for Salmonella. Although there was no statistical difference in prevalence rates and persistence, Salmonella was primarily reisolated from plastic feeders. The second experiment investigated the prevalence and persistence of Salmonella on picnic tables in a South Florida park that were contaminated with bird feces. Salmonella prevalence on the picnic tables was 27%. When tracking fecal piles over time, 33% to 42% of fecal piles were Salmonella culture positive for 1 to 4 days. A total of 13 to 14 serotypes were detected, of which 5 serovars are in the top 20 for human infections. Our trials indicate that Salmonella can persist on bird feeders and picnic tables and precautionary measures should be adopted to reduce exposure. The companion Currents in One Health by Seixas et al, JAVMA, forthcoming 2025, addresses in-depth information about Salmonella epidemiology in free-living birds.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of a point-of-care viscoelastic coagulation monitor and its comparison to thromboelastography in 9 female southern white rhinoceros (Ceratotherium simum simum).","authors":"Ashlyn C Heniff, Alex M Lynch, Laura K Ruterbories, Larry J Minter, Timothy A Georoff, Julie A Balko","doi":"10.2460/ajvr.24.10.0322","DOIUrl":"10.2460/ajvr.24.10.0322","url":null,"abstract":"<p><strong>Objective: </strong>To investigate a point-of-care viscoelastic coagulation monitor (VCM Vet; Entegrion Inc), compare the results to thromboelastography (TEG), and quantify traditional hemostatic analytes in southern white rhinoceros (Ceratotherium simum simum).</p><p><strong>Methods: </strong>9 female rhinoceros (4 juveniles [2 to 3 years old], 4 adults [16 to 34 years old], and 1 geriatric [54 years old]) at the North Carolina Zoo were enrolled. Whole blood was collected using trained voluntary behavior and analyzed in duplicate via both VCM Vet and kaolin-activated TEG within 4 minutes or at 30 minutes following collection, respectively. Citrated plasma was used for ancillary coagulation testing.</p><p><strong>Results: </strong>Both analyses generated quantifiable clotting reactions with variables (median [range]) related to clot formation rate (TEG: R = 9.4 minutes [5.1 to 10.8], K = 2.0 minutes [1.4 to 3.0], α angle = 66° [41° to 73°]; VCM Vet: CT = 882 seconds [758 to 1,252], CFT = 416 seconds [200 to 980], α = 24° [11° to 43°]), clot strength (TEG: MA = 71 mm [64 to 79], G = 11.9 kilodynes/s [9.0 to 18.9]; VCM Vet: MCF = 49 units [34 to 53]), and clot lysis (TEG: LY30 = 0.9% [0% to 1.7%], LY60 = 3.2% [0.9% to 4.9%]; VCM Vet: Li30 = 100% [99% to 100%], Li45 = 98% [93% to 100%]) recorded. Additional testing (median [range]) included D-dimer (221 ng/mL [138 to 577]), prothrombin time (21.4 seconds [19.6 to 23.7]), activated partial thromboplastin time (24.8 seconds [22.5 to 27.4]), and fibrinogen (336 mg/dL [280 to 429]).</p><p><strong>Conclusions: </strong>Tracings generated by VCM Vet and TEG were clinically similar, and there was visual agreement and minimal difference between quantitative variables for duplicate tests.</p><p><strong>Clinical relevance: </strong>VCM Vet is a user-friendly, portable device that demonstrates promise for assessing coagulation in southern white rhinoceros.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screw with tension band wiring method is an acceptable alternative to pins with tension band wiring in a canine cadaver model of extra-articular olecranon fracture.","authors":"Younwoo Choo, Jooyoung Kim, Jun-Sik Cho, Sorin Kim, Hwi-Yool Kim","doi":"10.2460/ajvr.24.12.0375","DOIUrl":"10.2460/ajvr.24.12.0375","url":null,"abstract":"<p><strong>Objective: </strong>To compare the maximum failure load and failure mode among 3 fixation methods for canine olecranon fractures and evaluate the feasibility of replacing the pin and tension band wiring method with screw plus tension band wiring (TBW) methods.</p><p><strong>Methods: </strong>18 ulnas from 9 canine cadavers (10.3 to 16.4 kg) were collected and randomly assigned to 3 groups (n = 6) for surgical procedures. Surgical procedures and biomechanical testing were performed from June 14 through October 7, 2024. A transverse ulnar osteotomy was performed immediately proximal to the anconeal process and aligned perpendicularly to the caudal cortex. In group 1, the pin and tension band wiring technique was employed using 2 1.2-mm Kirschner wires and #2 FiberWire. Group 2 applied the screw TBW method using a partially threaded cannulated screw and #2 FiberWire. Group 3 used the screw TBW method but with a fully threaded headless cannulated screw and #2 FiberWire. Biomechanical testing was conducted to apply tensile forces using a universal testing machine.</p><p><strong>Results: </strong>Maximum failure loads of groups 1 (n = 6), 2 (n = 6), and 3 (n = 6) were 351.3 ± 22.2 N, 345.78 ± 25.6 N, and 326.3 ± 18.2 N, respectively. No significant difference was observed in maximum failure loads among the groups.</p><p><strong>Conclusions: </strong>This study suggests that the screw with TBW methods represent viable alternatives for internal fixation in extra-articular transverse olecranon fractures in dogs.</p><p><strong>Clinical relevance: </strong>This study's results imply that fully threaded headless cannulated screws can be effectively applied to areas under tensile forces.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the potential bronchodilatory effect of propofol constant rate infusion for suspected reflex bronchoconstriction in isoflurane-anesthetized dogs.","authors":"Minha Kim, Inhyung Lee, Won-Gyun Son","doi":"10.2460/ajvr.24.11.0345","DOIUrl":"10.2460/ajvr.24.11.0345","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the bronchodilatory effect of propofol constant rate infusion (CRI) on PaO2 and PaCO2 in dogs with suspected bronchoconstriction.</p><p><strong>Methods: </strong>In this retrospective, observational study, anesthetic records from August 2022 through July 2023 at the Seoul National University Veterinary Medical Teaching Hospital were reviewed. Dogs with PaO2 < 300 mm Hg and PaCO2 > 45 mm Hg during mechanical ventilation under inhalation anesthesia receiving a propofol CRI were included. Ventilatory parameters and arterial blood gas results were extracted, reported as median (range). Arterial partial pressure of oxygen and PaCO2 values before and after propofol CRI were compared.</p><p><strong>Results: </strong>7 client-owned dogs were identified. Bronchoconstriction was suspected postintubation based on ventilatory parameters (tidal volume of 8.1 [6.0 to 9.3] mL/kg; compliance respiratory system of 0.6 [0.4 to 0.8] mL/cm H2O/kg) and arterial blood gas results. Despite immediate interventions, including optimizing mechanical ventilation, deepening anesthesia, and drug therapy, PaO2 remained < 300 mm Hg. Thus, a propofol CRI (12 to 14 mg/kg/h) was initiated. Arterial partial pressure of oxygen increased following propofol CRI, rising from 153.0 (75.5 to 233.0) mm Hg to 284.0 (183.0 to 386.0) mm Hg at 30 minutes (mean difference, 130.9 mm Hg; 95% CI, 21.4 to 240.3) and to 331.5 (236.0 to 458.0) mm Hg at 60 minutes (mean difference, 168.0 mm Hg; 95% CI, 93.0 to 244.5). Arterial partial pressure of carbon dioxide levels were similar without improvement. Postoperatively, 4 dogs exhibited hypoxemia, taking 60 to 135 minutes to recover.</p><p><strong>Conclusions: </strong>In dogs with perioperative gas exchange problems, PaO2 increased after propofol CRI, though PaCO2 levels remained unchanged.</p><p><strong>Clinical relevance: </strong>Propofol CRI improved oxygenation in dogs with suspected bronchoconstriction and may serve as a bronchodilatory treatment option.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mississippi State research serves rural practice needs.","authors":"David R Smith, Kimberly A Woodruff, W Isaac Jumper","doi":"10.2460/ajvr.25.03.0078","DOIUrl":"https://doi.org/10.2460/ajvr.25.03.0078","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":"86 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary cortisol-to-creatinine ratio using a chemiluminescent assay has limited diagnostic accuracy for canine hypercortisolism.","authors":"Francesca Del Baldo, Alessandro Tirolo, Francesco Dondi, Ada Sapignoli, Matteo Galeotti, Antonio Maria Tardo, Stefania Golinelli, Federico Fracassi","doi":"10.2460/ajvr.25.01.0020","DOIUrl":"10.2460/ajvr.25.01.0020","url":null,"abstract":"<p><strong>Objective: </strong>To establish the de novo reference interval (RI) for urinary cortisol-to-creatinine ratio (UCCR) in healthy dogs (HDs) using the currently available chemiluminescent enzyme immunoassay antibody (Veterinary Cortisol; IMMULITE 2000 XPi; Siemens Healthineers) and to evaluate UCCR diagnostic performance in dogs with hypercortisolism (HC).</p><p><strong>Methods: </strong>This was a retrospective, single-center, observational study. Stored urine samples from dogs with HC or diseases mimicking HC (DMHC) at the time of diagnosis were selected from July 2019 through November 2022. Healthy dogs were prospectively included. The diagnostic performance of the UCCR was assessed based on receiver operating characteristic curves.</p><p><strong>Results: </strong>One hundred seventy-two dogs were included: 97 with HC, 35 with DMHC, and 40 HDs. The de novo RI for UCCR in HDs was between 3 X 10-6 (90% CI, 2.3 X 10-6 to 3.8 X 10-6) and 26 X 10-6 (90% CI, 29.7 X 10-6 to 35.0 X 10-6). The median UCCR was significantly higher in dogs with HC (70.9 X 10-6; 6.8 X 10-6 to 882.2 X 10-6) as compared to dogs with DMHC (15 X 10-6; 2.63 X 10-6 to 137.8 X 10-6) and HDs (9.1 X 10-6; 3.9 X 10-6 to 36.3 X 10-6). The area under the receiver operating characteristic curve for UCCR to differentiate HC dogs from dogs with DMHC was 0.85 (95% CI, 0.78 to 0.92). Using the upper limit of the de novo RI as the cutoff value (UCCR > 26 X 10-6), the sensitivity and the specificity for the UCCR in diagnosing HC were 80.4% (95% CI, 71.1% to 87.8%) and 71.4% (95% CI, 53.7% to 85.4%), respectively.</p><p><strong>Conclusions: </strong>Using the upper limit of the de novo RI, UCCR showed modest performances not only due to low specificity but also due to a sensitivity of only 80.4%.</p><p><strong>Clinical relevance: </strong>UCCR should not be used alone to rule out HC in dogs, and, when the clinical suspicion for HC is present, other endocrine tests should be pursued.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sublingual microcirculation in isoflurane-anesthetized horses receiving dexmedetomidine and lidocaine constant rate infusion.","authors":"Laís L Garcia, Yuri F Vicentini, Julio K Nagashima, Anderson F de Souza, Marco A A Pereira, Luis C L C da Silva, Denise T Fantoni","doi":"10.2460/ajvr.24.11.0340","DOIUrl":"10.2460/ajvr.24.11.0340","url":null,"abstract":"<p><strong>Objective: </strong>To assess the sublingual microcirculation in horses anesthetized with isoflurane and undergoing constant rate infusion of dexmedetomidine (DEX) and lidocaine (LID).</p><p><strong>Methods: </strong>16 horses undergoing arthroscopy were included in a blind, randomized study comparing 2 groups: a DEX group (DEX-LID; 1.75 μg·kg-1·h-1 with a LID bolus of 1.3 mg·kg-1 followed by a continuous infusion of 0.05 mg·kg-1·min-1) and a LID-only group (LID; at the same dose). Hemodynamic variables, including mean, systolic, and diastolic blood pressure; heart rate; capnography; blood gas analysis; blood lactate; and orthogonal polarization spectral imaging were measured. Measurements were taken before infusion and at 15, 30, and 60 minutes after infusion initiation.</p><p><strong>Results: </strong>No differences were observed in microcirculation variables between the groups. At 60 minutes, the total vessel density was 18.73 ± 0.97, the microvascular flow index 3.59 ± 0.39, and the De Backer score 12.4 ± 0.95 in the DEX-LID group. The total vessel density was 20.15 ± 2.23, microvascular flow index 3.62 ± 0.5, and De Backer score 13.41 ± 2.32 for the LID group. Notably, 5 of 8 horses in the LID group required ephedrine for hypotension management (mean arterial pressure < 65 mm Hg), whereas none in the DEX-LID group did.</p><p><strong>Conclusions: </strong>The combination of DEX and LID during isoflurane anesthesia provided stable hemodynamic conditions during arthroscopic surgery in horses without adversely affecting sublingual microcirculation or recovery.</p><p><strong>Clinical relevance: </strong>These findings support that the combination of DEX and LID maintains hemodynamic variables during surgery without compromising microcirculation function.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographs acquired before total hip replacement in dogs underestimate femoral canal flare and misjudge trochanteric overhang.","authors":"Sohee Bae, Denis J Marcellin-Little, Ridhdi Pritikin, Tanya C Garcia","doi":"10.2460/ajvr.25.02.0045","DOIUrl":"10.2460/ajvr.25.02.0045","url":null,"abstract":"<p><strong>Objective: </strong>To compare measurements of canal flare index (CFI) and greater trochanter overhang (TrO) from ventrodorsal (VD) and craniocaudal horizontal beam (CCHB) radiographic views to measurements from contemporaneously acquired CT scans and to evaluate the impact of size, age, radiographic view, severity of osteoarthritis, hip subluxation, and femoral rotational malposition on CFI and TrO measurement accuracy.</p><p><strong>Methods: </strong>This was a retrospective study of femurs imaged from June 28, 2018, through March 27, 2023. The CFI and linear TrO index measured from VD and CCHB radiographs and from CT-derived surface renderings of the femur prepared with -10°, -5°, 0°, +5°, and +10° of rotation using computer-aided design software were compared.</p><p><strong>Results: </strong>80 femora from 43 dogs were included. Radiographs measured CFI with errors > 0.2 in 81% of VD views and 77% of CCHB views and yielded linear TrO measurements with errors > 20% of canal radius in 75% of VD and 74% of CCHB views. The TrO grade was incorrect for 44% of femurs on VD views and 30% of femurs on CCHB views. Internal femoral rotation of 10° significantly influenced CT measurements of CFI and TrO. Severity of osteoarthritis and hip subluxation did not influence measurements.</p><p><strong>Conclusions: </strong>Measurements of CFI and TrO from VD and CCHB views are inaccurate relative to CT measurements.</p><p><strong>Clinical relevance: </strong>Radiographic measurements underestimate CFI and poorly predict TrO. A CT of the femur should be considered when accurate measurements of CFI and TrO are sought, particularly for femurs with abnormal geometry.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased adventitial thickening is a feature of pulmonary arterial remodeling in cats with bronchiolar disorders.","authors":"Rachel St-Arnaud Massicotte, Kurt Williams, Carol Reinero, Bérénice Conversy, Isabelle Masseau","doi":"10.2460/ajvr.25.02.0039","DOIUrl":"10.2460/ajvr.25.02.0039","url":null,"abstract":"<p><strong>Objective: </strong>To compare pulmonary arterial remodeling in cats with histopathologic diagnosis of bronchiolar disorder (BD) to control cats without BD.</p><p><strong>Methods: </strong>Lung tissue from cats with primary or secondary BD (n = 13) were compared to control cats without histopathological evidence of pulmonary and cardiac disease (n = 13). Wall-to-lumen ratio scores, wall cross-sectional area, and intimal, medial, and adventitial tunic areas were compared between groups for small (70 to 300 μm), medium (301 to 999 μm), and large (≥ 1,000 µm) pulmonary arteries. Analysis used linear or linear mixed models and γ-log or arcsine distributions. Post hoc tests were performed, when applicable, with the Tukey method. Benjamini-Hochberg corrections were applied to multiple pairwise comparisons.</p><p><strong>Results: </strong>Remodeling of pulmonary arteries was found in both groups, affecting more small pulmonary arteries, medium pulmonary arteries, and large pulmonary arteries, in that order. Pulmonary arterial remodeling in cats without BD consisted of medial hypertrophy and occasional intimal fibrosis. While having changes to the intima and media, cats with BD also showed increased adventitial collagen. No significant differences were noted between groups for wall-to-lumen scores and wall cross-sectional area for all 3 categories of arteries. Adventitial area was, on average, 1.3-fold larger in cats with BD compared to controls (P = .012), whereas no difference was found for intimal and medial areas between groups (P = .05).</p><p><strong>Conclusions: </strong>The results show that cats with BD have a thicker adventitial tunic than control cats.</p><p><strong>Clinical relevance: </strong>The adventitial tunic of pulmonary arteries may represent a potential target for therapy in cats with BD.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}