Investigation of the potential bronchodilatory effect of propofol constant rate infusion for suspected reflex bronchoconstriction in isoflurane-anesthetized dogs.

IF 1.3 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2025-04-16 DOI:10.2460/ajvr.24.11.0345

Minha Kim, Inhyung Lee, Won-Gyun Son

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引用次数: 0

Abstract

Objective: To evaluate the bronchodilatory effect of propofol constant rate infusion (CRI) on PaO2 and PaCO2 in dogs with suspected bronchoconstriction.

Methods: In this retrospective, observational study, anesthetic records from August 2022 through July 2023 at the Seoul National University Veterinary Medical Teaching Hospital were reviewed. Dogs with PaO2 < 300 mm Hg and PaCO2 > 45 mm Hg during mechanical ventilation under inhalation anesthesia receiving a propofol CRI were included. Ventilatory parameters and arterial blood gas results were extracted, reported as median (range). Arterial partial pressure of oxygen and PaCO2 values before and after propofol CRI were compared.

Results: 7 client-owned dogs were identified. Bronchoconstriction was suspected postintubation based on ventilatory parameters (tidal volume of 8.1 [6.0 to 9.3] mL/kg; compliance respiratory system of 0.6 [0.4 to 0.8] mL/cm H2O/kg) and arterial blood gas results. Despite immediate interventions, including optimizing mechanical ventilation, deepening anesthesia, and drug therapy, PaO2 remained < 300 mm Hg. Thus, a propofol CRI (12 to 14 mg/kg/h) was initiated. Arterial partial pressure of oxygen increased following propofol CRI, rising from 153.0 (75.5 to 233.0) mm Hg to 284.0 (183.0 to 386.0) mm Hg at 30 minutes (mean difference, 130.9 mm Hg; 95% CI, 21.4 to 240.3) and to 331.5 (236.0 to 458.0) mm Hg at 60 minutes (mean difference, 168.0 mm Hg; 95% CI, 93.0 to 244.5). Arterial partial pressure of carbon dioxide levels were similar without improvement. Postoperatively, 4 dogs exhibited hypoxemia, taking 60 to 135 minutes to recover.

Conclusions: In dogs with perioperative gas exchange problems, PaO2 increased after propofol CRI, though PaCO2 levels remained unchanged.

Clinical relevance: Propofol CRI improved oxygenation in dogs with suspected bronchoconstriction and may serve as a bronchodilatory treatment option.

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异氟醚麻醉犬疑似反射性支气管收缩时异丙酚恒速输注潜在支气管扩张效应的研究。

目的：探讨异丙酚恒速输注（CRI）对疑似支气管收缩犬PaO2和PaCO2的影响。方法：在这项回顾性观察性研究中，回顾了首尔国立大学兽医教学医院2022年8月至2023年7月的麻醉记录。本研究纳入了吸入性麻醉下机械通气时PaO2 < 300 mm Hg、PaCO2 > > 45 mm Hg且接受异丙酚CRI的犬。提取通气参数和动脉血气结果，报告为中位数（范围）。比较异丙酚CRI前后动脉血氧分压和PaCO2值。结果：鉴定出7只客户拥有的狗。根据通气参数(潮气量8.1 [6.0 ~ 9.3]mL/kg；呼吸系统依从性为0.6 [0.4 ~ 0.8]mL/cm H2O/kg)及动脉血气结果。尽管立即采取干预措施，包括优化机械通气、加深麻醉和药物治疗，但PaO2仍< 300 mm Hg。因此，开始使用异丙酚CRI（12至14 mg/kg/h）。异丙酚CRI后动脉血氧分压升高，30分钟从153.0 (75.5 ~ 233.0)mm Hg上升到284.0 (183.0 ~ 386.0)mm Hg(平均差130.9 mm Hg；95% CI， 21.4至240.3)和331.5(236.0至458.0)mm Hg在60分钟(平均差，168.0 mm Hg；95% CI, 93.0 ~ 244.5)。动脉分压二氧化碳水平相似，但没有改善。术后4只狗出现低氧血症，需60 ~ 135分钟恢复。结论：在有围手术期气体交换问题的犬中，异丙酚CRI后PaO2升高，但PaCO2水平保持不变。临床相关性：异丙酚CRI可改善疑似支气管收缩犬的氧合，可作为支气管扩张治疗选择。

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来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.