Intra-articular injections of polynucleotides show promise in improving clinical outcomes compared to hyaluronic acid in small-breed dogs with osteoarthritis.
Chae-Lim Lee, Yongsun Kim, Jong-In Kim, Changsu Jung, Sumin Kim, Kyu-Won Kang, Byung-Jae Kang
{"title":"Intra-articular injections of polynucleotides show promise in improving clinical outcomes compared to hyaluronic acid in small-breed dogs with osteoarthritis.","authors":"Chae-Lim Lee, Yongsun Kim, Jong-In Kim, Changsu Jung, Sumin Kim, Kyu-Won Kang, Byung-Jae Kang","doi":"10.2460/ajvr.25.07.0243","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare the therapeutic effects of IA polynucleotide (PN) and hyaluronic acid (HA) injections in small-breed dogs with osteoarthritis.</p><p><strong>Methods: </strong>A multicenter, prospective, comparative, randomized, blinded clinical study was conducted from February 2024 to January 2025 at a university veterinary hospital and 3 veterinary clinics. Client-owned small-breed dogs (< 15 kg) with hindlimb osteoarthritis, confirmed by clinical signs and radiographic findings, were assigned to receive 2 IA injections of either HA or PN at a 1:2 ratio, with a 2-week interval. Clinical outcomes were evaluated at weeks 0, 2, 4, 8, and 12 using 2 validated clinical metrology instruments, the Canine Orthopedic Index (COI; function, gait, stiffness, and quality of life) and Canine Brief Pain Inventory (CBPI; pain severity score [PSS] and pain interference score [PIS]).</p><p><strong>Results: </strong>Of the 34 enrolled dogs, 27 completed the study (HA, n = 9; PN, 18). The mean age was 6.3 years, with a median weight of 4.8 kg. The PN group showed significantly greater improvements in COI, stiffness, CBPI, and PIS compared with the HA group at week 12. The PN-treated dogs also experienced earlier or more sustained improvements in COI, stiffness, gait, CBPI, PSS, and PIS. The COI-defined success was observed from weeks 4 to 12 in the PN group and at week 8 in the HA group.</p><p><strong>Conclusions: </strong>The IA PN injections resulted in earlier, greater, and more sustained clinical improvements than HA in dogs with osteoarthritis.</p><p><strong>Clinical relevance: </strong>Injections of PN may offer a more effective alternative to HA for managing canine osteoarthritis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.25.07.0243","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To compare the therapeutic effects of IA polynucleotide (PN) and hyaluronic acid (HA) injections in small-breed dogs with osteoarthritis.
Methods: A multicenter, prospective, comparative, randomized, blinded clinical study was conducted from February 2024 to January 2025 at a university veterinary hospital and 3 veterinary clinics. Client-owned small-breed dogs (< 15 kg) with hindlimb osteoarthritis, confirmed by clinical signs and radiographic findings, were assigned to receive 2 IA injections of either HA or PN at a 1:2 ratio, with a 2-week interval. Clinical outcomes were evaluated at weeks 0, 2, 4, 8, and 12 using 2 validated clinical metrology instruments, the Canine Orthopedic Index (COI; function, gait, stiffness, and quality of life) and Canine Brief Pain Inventory (CBPI; pain severity score [PSS] and pain interference score [PIS]).
Results: Of the 34 enrolled dogs, 27 completed the study (HA, n = 9; PN, 18). The mean age was 6.3 years, with a median weight of 4.8 kg. The PN group showed significantly greater improvements in COI, stiffness, CBPI, and PIS compared with the HA group at week 12. The PN-treated dogs also experienced earlier or more sustained improvements in COI, stiffness, gait, CBPI, PSS, and PIS. The COI-defined success was observed from weeks 4 to 12 in the PN group and at week 8 in the HA group.
Conclusions: The IA PN injections resulted in earlier, greater, and more sustained clinical improvements than HA in dogs with osteoarthritis.
Clinical relevance: Injections of PN may offer a more effective alternative to HA for managing canine osteoarthritis.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
