Chae-Lim Lee, Yongsun Kim, Jong-In Kim, Changsu Jung, Sumin Kim, Kyu-Won Kang, Byung-Jae Kang
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Clinical outcomes were evaluated at weeks 0, 2, 4, 8, and 12 using 2 validated clinical metrology instruments, the Canine Orthopedic Index (COI; function, gait, stiffness, and quality of life) and Canine Brief Pain Inventory (CBPI; pain severity score [PSS] and pain interference score [PIS]).</p><p><strong>Results: </strong>Of the 34 enrolled dogs, 27 completed the study (HA, n = 9; PN, 18). The mean age was 6.3 years, with a median weight of 4.8 kg. The PN group showed significantly greater improvements in COI, stiffness, CBPI, and PIS compared with the HA group at week 12. The PN-treated dogs also experienced earlier or more sustained improvements in COI, stiffness, gait, CBPI, PSS, and PIS. The COI-defined success was observed from weeks 4 to 12 in the PN group and at week 8 in the HA group.</p><p><strong>Conclusions: </strong>The IA PN injections resulted in earlier, greater, and more sustained clinical improvements than HA in dogs with osteoarthritis.</p><p><strong>Clinical relevance: </strong>Injections of PN may offer a more effective alternative to HA for managing canine osteoarthritis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4000,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intra-articular injections of polynucleotides show promise in improving clinical outcomes compared to hyaluronic acid in small-breed dogs with osteoarthritis.\",\"authors\":\"Chae-Lim Lee, Yongsun Kim, Jong-In Kim, Changsu Jung, Sumin Kim, Kyu-Won Kang, Byung-Jae Kang\",\"doi\":\"10.2460/ajvr.25.07.0243\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare the therapeutic effects of IA polynucleotide (PN) and hyaluronic acid (HA) injections in small-breed dogs with osteoarthritis.</p><p><strong>Methods: </strong>A multicenter, prospective, comparative, randomized, blinded clinical study was conducted from February 2024 to January 2025 at a university veterinary hospital and 3 veterinary clinics. 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引用次数: 0
摘要
目的：比较IA多核苷酸（PN）与透明质酸（HA）注射对小品种犬骨关节炎的治疗效果。方法：于2024年2月至2025年1月在某大学兽医院和3家兽医诊所进行多中心、前瞻性、比较、随机、盲法临床研究。客户拥有的患有后肢骨关节炎的小品种犬（< 15 kg），经临床症状和影像学检查证实，按1:2的比例接受2次IA注射，注射HA或PN，间隔2周。临床结果在第0、2、4、8和12周使用2种经过验证的临床计量工具，犬矫形指数（COI；功能、步态、僵硬度和生活质量）和犬短暂疼痛量表（CBPI；疼痛严重程度评分[PSS]和疼痛干扰评分[PIS]）进行评估。结果：在34只入组犬中，27只完成了研究（HA, n = 9； PN, 18）。平均年龄为6.3岁，中位体重为4.8公斤。在第12周，与HA组相比，PN组在COI、僵硬度、CBPI和PIS方面的改善明显更大。接受pn治疗的狗在COI、僵硬度、步态、CBPI、PSS和PIS方面也经历了更早或更持久的改善。从第4周到第12周，PN组和HA组在第8周观察到coi定义的成功。结论：与HA相比，IA PN注射对骨关节炎犬的临床改善更早、更大、更持久。临床相关性：注射PN可能是治疗犬骨关节炎更有效的选择。
Intra-articular injections of polynucleotides show promise in improving clinical outcomes compared to hyaluronic acid in small-breed dogs with osteoarthritis.
Objective: To compare the therapeutic effects of IA polynucleotide (PN) and hyaluronic acid (HA) injections in small-breed dogs with osteoarthritis.
Methods: A multicenter, prospective, comparative, randomized, blinded clinical study was conducted from February 2024 to January 2025 at a university veterinary hospital and 3 veterinary clinics. Client-owned small-breed dogs (< 15 kg) with hindlimb osteoarthritis, confirmed by clinical signs and radiographic findings, were assigned to receive 2 IA injections of either HA or PN at a 1:2 ratio, with a 2-week interval. Clinical outcomes were evaluated at weeks 0, 2, 4, 8, and 12 using 2 validated clinical metrology instruments, the Canine Orthopedic Index (COI; function, gait, stiffness, and quality of life) and Canine Brief Pain Inventory (CBPI; pain severity score [PSS] and pain interference score [PIS]).
Results: Of the 34 enrolled dogs, 27 completed the study (HA, n = 9; PN, 18). The mean age was 6.3 years, with a median weight of 4.8 kg. The PN group showed significantly greater improvements in COI, stiffness, CBPI, and PIS compared with the HA group at week 12. The PN-treated dogs also experienced earlier or more sustained improvements in COI, stiffness, gait, CBPI, PSS, and PIS. The COI-defined success was observed from weeks 4 to 12 in the PN group and at week 8 in the HA group.
Conclusions: The IA PN injections resulted in earlier, greater, and more sustained clinical improvements than HA in dogs with osteoarthritis.
Clinical relevance: Injections of PN may offer a more effective alternative to HA for managing canine osteoarthritis.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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