Andrea Wright, Chloe Howse, George Skingley, George Valiakos, Ioulia Chortara, Mollie Lowe, Mary Nabity, Jonathan Elliott, Jan Stochl, Aoife Mahon-Smith
{"title":"新的狗慢性肾脏疾病健康相关生活质量问卷证明了在犬临床试验中使用的可靠性和有效性。","authors":"Andrea Wright, Chloe Howse, George Skingley, George Valiakos, Ioulia Chortara, Mollie Lowe, Mary Nabity, Jonathan Elliott, Jan Stochl, Aoife Mahon-Smith","doi":"10.2460/ajvr.25.02.0051","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate an owner-reported questionnaire designed to measure health-related quality of life (HRQoL) in dogs with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>This noninterventional study followed best practice guidance for instrument development. Draft items were initially identified through a qualitative literature and social media review. Concept elicitation and cognitive debriefing interviews with owners of dogs with CKD further informed item development and modification. Psychometric properties were then evaluated in a larger sample, alongside 2 global items assessing the dog's HRQoL from the owner's and veterinarian's perspective. Expert veterinarian input was provided throughout.</p><p><strong>Results: </strong>Owners of 11 dogs with CKD were recruited for interviews, and owners of 279 dogs with CKD were recruited for psychometric evaluation. Forty-eight signs and behaviors of CKD were identified from the literature and social media review; an additional 13 concepts were identified in the qualitative interviews. The final questionnaire comprised 13 items assessing observable HRQoL impacts of CKD in dogs and demonstrated reliability and validity in terms of psychometric properties. Factor and item response theory analyses confirmed the questionnaire's unidimensional structure. High internal consistency (Cronbach alpha = 0.89; McDonald omega = 0.89), moderate to good test-retest reliability (≥ 0.73), and strong convergent validity evidence were found. The questionnaire demonstrated the ability to discriminate between early International Renal Interest Society stages and different levels of owner- and veterinarian-reported overall dog HRQoL.</p><p><strong>Conclusions: </strong>This is the first psychometrically validated questionnaire assessing HRQoL in canine CKD.</p><p><strong>Clinical relevance: </strong>The measure is fit for purpose for use in canine CKD both in clinical trials and veterinary practice.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4000,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The new Health-Related Quality of Life in Dog Chronic Kidney Disease Questionnaire demonstrates reliability and validity for use in canine clinical trials.\",\"authors\":\"Andrea Wright, Chloe Howse, George Skingley, George Valiakos, Ioulia Chortara, Mollie Lowe, Mary Nabity, Jonathan Elliott, Jan Stochl, Aoife Mahon-Smith\",\"doi\":\"10.2460/ajvr.25.02.0051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To develop and validate an owner-reported questionnaire designed to measure health-related quality of life (HRQoL) in dogs with chronic kidney disease (CKD).</p><p><strong>Methods: </strong>This noninterventional study followed best practice guidance for instrument development. Draft items were initially identified through a qualitative literature and social media review. Concept elicitation and cognitive debriefing interviews with owners of dogs with CKD further informed item development and modification. Psychometric properties were then evaluated in a larger sample, alongside 2 global items assessing the dog's HRQoL from the owner's and veterinarian's perspective. Expert veterinarian input was provided throughout.</p><p><strong>Results: </strong>Owners of 11 dogs with CKD were recruited for interviews, and owners of 279 dogs with CKD were recruited for psychometric evaluation. Forty-eight signs and behaviors of CKD were identified from the literature and social media review; an additional 13 concepts were identified in the qualitative interviews. The final questionnaire comprised 13 items assessing observable HRQoL impacts of CKD in dogs and demonstrated reliability and validity in terms of psychometric properties. Factor and item response theory analyses confirmed the questionnaire's unidimensional structure. High internal consistency (Cronbach alpha = 0.89; McDonald omega = 0.89), moderate to good test-retest reliability (≥ 0.73), and strong convergent validity evidence were found. The questionnaire demonstrated the ability to discriminate between early International Renal Interest Society stages and different levels of owner- and veterinarian-reported overall dog HRQoL.</p><p><strong>Conclusions: </strong>This is the first psychometrically validated questionnaire assessing HRQoL in canine CKD.</p><p><strong>Clinical relevance: </strong>The measure is fit for purpose for use in canine CKD both in clinical trials and veterinary practice.</p>\",\"PeriodicalId\":7754,\"journal\":{\"name\":\"American journal of veterinary research\",\"volume\":\" \",\"pages\":\"1-9\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-09-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of veterinary research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.2460/ajvr.25.02.0051\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.25.02.0051","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
The new Health-Related Quality of Life in Dog Chronic Kidney Disease Questionnaire demonstrates reliability and validity for use in canine clinical trials.
Objective: To develop and validate an owner-reported questionnaire designed to measure health-related quality of life (HRQoL) in dogs with chronic kidney disease (CKD).
Methods: This noninterventional study followed best practice guidance for instrument development. Draft items were initially identified through a qualitative literature and social media review. Concept elicitation and cognitive debriefing interviews with owners of dogs with CKD further informed item development and modification. Psychometric properties were then evaluated in a larger sample, alongside 2 global items assessing the dog's HRQoL from the owner's and veterinarian's perspective. Expert veterinarian input was provided throughout.
Results: Owners of 11 dogs with CKD were recruited for interviews, and owners of 279 dogs with CKD were recruited for psychometric evaluation. Forty-eight signs and behaviors of CKD were identified from the literature and social media review; an additional 13 concepts were identified in the qualitative interviews. The final questionnaire comprised 13 items assessing observable HRQoL impacts of CKD in dogs and demonstrated reliability and validity in terms of psychometric properties. Factor and item response theory analyses confirmed the questionnaire's unidimensional structure. High internal consistency (Cronbach alpha = 0.89; McDonald omega = 0.89), moderate to good test-retest reliability (≥ 0.73), and strong convergent validity evidence were found. The questionnaire demonstrated the ability to discriminate between early International Renal Interest Society stages and different levels of owner- and veterinarian-reported overall dog HRQoL.
Conclusions: This is the first psychometrically validated questionnaire assessing HRQoL in canine CKD.
Clinical relevance: The measure is fit for purpose for use in canine CKD both in clinical trials and veterinary practice.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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