Journal of Functional Foods最新文献

Nutritional and health promoting properties of traditional regional foods: Harnessing omics techniques for microbial and metabolite identification 传统地方食品的营养和健康促进特性：利用组学技术进行微生物和代谢物鉴定

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-30 DOI: 10.1016/j.jff.2025.106919

Sonal Aggarwal, Deepika Kathuria, Narpinder Singh

{"title":"Nutritional and health promoting properties of traditional regional foods: Harnessing omics techniques for microbial and metabolite identification","authors":"Sonal Aggarwal, Deepika Kathuria, Narpinder Singh","doi":"10.1016/j.jff.2025.106919","DOIUrl":"10.1016/j.jff.2025.106919","url":null,"abstract":"<div><div>Traditional food is an integral part of cultural heritage and identity for indigenous peoples' worldwide. It reflects a rich tapestry of flavours, textures, and nutritional benefits that resonate both locally and globally. Traditional foods encapsulate centuries-old culinary practices and embody a profound connection to local ecosystems, climates, and cultural heritage. Asia, with its vast geographical area and cultural diversity, boasts a particularly diverse regional cuisine. Historically, citizens were unaware of the health benefits of their traditional regional foods, but scientific advancements have illuminated these advantages, leading to global promotion of local cuisines, for example, toddy and shalgam or India origin delivered anti-tumor properties and were heart-friendly foods; various pickles (through the globe) contributed to reducing serum cholesterol, were heart-nurturing and improved digestion; jamu kunir asem (Indonesia) aided in curing respiratory disorders and shown antiviral activities; gilaburu juice (Turkey) relieved renal disorders, respiratory disorders, and hypertension; and kimchi (Korea) prohibited tumor formation and possessed anti-hyperglycemic activity. From fermented pickles to probiotic-rich dairy products, traditional foods were shown provide an array of bioactive compounds and nutrients contributing to overall well-being. Furthermore, the integration of meta-omics tools enables researchers to unravel the secrets of traditional fermentation processes, ensuring both safety and authenticity while navigating the delicate balance between cultural authenticity and contemporary dietary needs. This article explores various traditional foods from different regions across the globe, their metabolites, and associated health benefits</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106919"},"PeriodicalIF":3.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intake of high-purity dietary fiber from Okara to prevent intestinal damage caused by acute ulcerative colitis 摄入高纯度的Okara膳食纤维，预防急性溃疡性结肠炎引起的肠道损伤

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-28 DOI: 10.1016/j.jff.2025.106918

Wang Yi , Zhang Ruining , An Bohan , Huang Xiaolong , Fu Hongling , Gao Junjie , Khalid Amin , Lyu Bo , Yu Hansong

{"title":"Intake of high-purity dietary fiber from Okara to prevent intestinal damage caused by acute ulcerative colitis","authors":"Wang Yi , Zhang Ruining , An Bohan , Huang Xiaolong , Fu Hongling , Gao Junjie , Khalid Amin , Lyu Bo , Yu Hansong","doi":"10.1016/j.jff.2025.106918","DOIUrl":"10.1016/j.jff.2025.106918","url":null,"abstract":"<div><div>High-purity insoluble dietary fiber (HPIDF) from okara has been proved to improve the colonic environment in case of acute ulcerative colitis (AUC). However, the effect of dietary fiber (DF) daily intake, on prevention and decline of AUC is not clear. In this study we investigated the effect of DF daily intake, on improving the overall colon condition during AUC, by establishing an animal model. A 21 days daily intake plan of HPIDF and low-purity dietary fiber (LPDF) from okara was used, by feeding C57BL/6 mice before induction of AUC. The AUC was induced post 21 days daily intake plan in mice through dextran sulfate sodium (DSS). The levels of inflammatory factors, the colonic internal environment (composition of microorganisms and short-chain fatty acids [SCFASs]), and bioinformatics were analyzed with the colonic tissue status. Results showed that the daily intake of HPIDF can protect against excessive colonic injury, maintain the stability of SCFASs, alleviate the inflammatory response and stabilize microbial structure when AUC occurs. Bioinformatics showed that the changes in the internal environment in the colon were mostly related to the biosynthetic process, such as amino acids, carbohydrates, cell structure, vitamins, lipids and fatty acids. This study demonstrated that daily intake of HPIDF have the potential to prevent excessive colonic injury when AUC occurs, although the hyperplasia of some non-probiotics was also accompanied by this process.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106918"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of anti-AD active ingredients from Huai yam using surface plasmon resonance technology and mechanistic exploration based on ERβ-harmonized inflammation and autophagy 应用表面等离子体共振技术检测槐山药抗ad活性成分及基于er β协调炎症和自噬的机理探讨

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-27 DOI: 10.1016/j.jff.2025.106915

Mengnan Zeng , Kaili Ye , Yuanyuan Wang , Fangzhuo Chang , Bing Cao , Fengxiao Hao , Pengli Guo , Yuhan Zhang , Ziyu Zhang , Weisheng Feng , Xiaoke Zheng

{"title":"Detection of anti-AD active ingredients from Huai yam using surface plasmon resonance technology and mechanistic exploration based on ERβ-harmonized inflammation and autophagy","authors":"Mengnan Zeng , Kaili Ye , Yuanyuan Wang , Fangzhuo Chang , Bing Cao , Fengxiao Hao , Pengli Guo , Yuhan Zhang , Ziyu Zhang , Weisheng Feng , Xiaoke Zheng","doi":"10.1016/j.jff.2025.106915","DOIUrl":"10.1016/j.jff.2025.106915","url":null,"abstract":"<div><div>Huai yam is a model of “medicinal and edible homology” plants in China that have been used to treat Alzheimer's disease (AD) for a long time. This study prepared the AD model using 5 × FAD transgenic mice, explore the active ingredients and mechanism of Huai yam on AD using surface plasmon resonance (SPR) ligand fishing technology and biological methods, and provide an experimental basis for the clinical treatment of AD. Yam and affinity component (1-methoxycarbonyl-<em>β</em>-carboline) detected by SPR technology improved cognitive ability and neuronal damage, transformed immune cells from peripheral blood, reduced brain inflammation and apoptosis, and upregulated the levels of autophagy via ER<em>β</em>. Moreover, 1-methoxycarbonyl-<em>β</em>-carboline also regulated metabolic disorders in 5 × FAD transgenic mice. These data provide a further pharmacological basis for the clinical application of Huai yam to prevent AD and help to understand the herbal function and “homology of medicine and food”.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106915"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women: A double-blinded randomized clinical trial 合成补充剂对绝经后妇女人体测量指标和骨代谢的影响：一项双盲随机临床试验

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-27 DOI: 10.1016/j.jff.2025.106906

Gu Yuming , Lu Zhejun , Sun Longyu , Zong Chenyu , Han Qinglin

{"title":"The effect of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women: A double-blinded randomized clinical trial","authors":"Gu Yuming , Lu Zhejun , Sun Longyu , Zong Chenyu , Han Qinglin","doi":"10.1016/j.jff.2025.106906","DOIUrl":"10.1016/j.jff.2025.106906","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the effects of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women.</div></div><div><h3>Methods</h3><div>In this randomized, double-blind, placebo-controlled trial, 52 postmenopausal women were received synbiotic or placebo for six months. Anthropometric measurements, bone mineral density (BMD), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (P1NP), tartrate-resistant acid phosphatase 5b (TRAP-5b), and bone-specific alkaline phosphatase (BSAP) were assessed.</div></div><div><h3>Results</h3><div>Although there were no considerable differences in BMI, fat mass, or BMD between groups, a significant decrease was observed in the synbiotic group regarding visceral fat content (<em>p</em> = 0.004), TRAP-5b (<em>p</em> < 0.001), BSAP (<em>p</em> = 0.003), and CTX (<em>p</em> = 0.028). No substantial changes were observed in OPG, RANKL, OC, or P1NP (<em>p</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Synbiotic supplementation significantly reduced visceral fat and markers of bone resorption in postmenopausal women.</div><div><strong>Clinical trial registration:</strong> ChiCTR2300076114.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106906"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supplementation of deep-sea mineral water improves the anti-cancer effects of tomato in colorectal cancer cells 补充深海矿泉水可提高番茄对结直肠癌细胞的抗癌作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-24 DOI: 10.1016/j.jff.2025.106914

Okin Abidemi Oluwasanmi , Sin-il Sin , Seung-Hwan Park , Anna Han

{"title":"Supplementation of deep-sea mineral water improves the anti-cancer effects of tomato in colorectal cancer cells","authors":"Okin Abidemi Oluwasanmi , Sin-il Sin , Seung-Hwan Park , Anna Han","doi":"10.1016/j.jff.2025.106914","DOIUrl":"10.1016/j.jff.2025.106914","url":null,"abstract":"<div><div>Tomato (<em>Solanum lycopersicum</em>) is a well-known anti-cancer food; however, the impact of cultivation methods on its anti-cancer effects is unexplored. Deep sea water (DSW) contains high concentrations of various minerals, offering diverse health-positive outcomes. This study compared the anti-cancer effects of tomatoes cultivated conventionally (REG), organically (OG), and organically with DSW supplementation (ODSW). Among all tomato extracts (TEs), ODSW had the highest activities of ABTS, DPPH, total phenolic and flavonoids. All TEs significantly decreased the cell viability, cell migration, and colony formation of HCT116 and Caco2 cells; however, compared to REG and OG, ODSW led to a further decrease of those indicators. Additionally, ODSW suppressed cell cycle regulation proteins (e.g., p-STAT3 and occludin) than REG and OG. Moreover, ODSW produced a high level of pro-apoptotic protein (e.g., Bim) relative to REG and OG. These findings suggest that DSW-supplementation organic cultivation can improve the efficacy of tomatoes' anti-cancer effects in CRC cells.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106914"},"PeriodicalIF":3.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prebiotic activity of functional whole mushroom powders in short-term in vitro colonic simulations 功能性全蘑菇粉在短期体外结肠模拟中的益生元活性

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-23 DOI: 10.1016/j.jff.2025.106912

Julie Daoust , Jay Schmalz , Lieven Van Meulebroek , Jonas Ghyselinck , Lynn Verstrepen , Massimo Marzorati

{"title":"Prebiotic activity of functional whole mushroom powders in short-term in vitro colonic simulations","authors":"Julie Daoust , Jay Schmalz , Lieven Van Meulebroek , Jonas Ghyselinck , Lynn Verstrepen , Massimo Marzorati","doi":"10.1016/j.jff.2025.106912","DOIUrl":"10.1016/j.jff.2025.106912","url":null,"abstract":"<div><div>Minimally processed, whole mushroom powders (Cordyceps [<em>Cordyceps militaris</em>], Reishi [<em>Ganoderma lucidum s.l.</em>], Lion's Mane [<em>Hericium erinaceus</em>], and Turkey Tail [<em>Trametes versicolor</em>]) and blends (GRAS blend, 4 species; MaxSpectrum blend, 10 species) were evaluated for their effects on the human gut microbiota. Short-term in vitro colonic simulations were performed. Metabolic changes, including significant increases in acetate, propionate, and butyrate levels were observed with all test products versus untreated control. Further, beneficial bacteria were enhanced with all test products. Caco-2/THP1 co-culture studies with fermentations from Cordyceps, Reishi, and MaxSpectrum blend colonic simulations demonstrated significant improvement in intestinal barrier function with all test products versus untreated control (fecal donor-dependent). Test product-dependent/donor-dependent pro-inflammatory molecule (TNFα, CXCL10, MCP-1) decreases and anti-inflammatory cytokine (IL-6 and IL-10) increases were observed versus untreated control. Tryptamine levels increased and pyruvic acid levels decreased with these test products versus untreated control. All six mushroom products demonstrated prebiotic properties.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106912"},"PeriodicalIF":3.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational disruption of paired helical filaments (PHFs) assembly using Milk Lactalbumin-derived peptides against Alzheimer's disease 使用乳乳清蛋白衍生肽对阿尔茨海默病的成对螺旋细丝（phf）组装的计算破坏

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-22 DOI: 10.1016/j.jff.2025.106853

Saeed Pourmand , Sara Zareei , Mohanna Jozi , Shokoufeh Massahi

引用次数: 0

Anti-osteoporosis activity and mechanism analyses of Limosilactobacillus fermentum YSC5001 from Chinese traditional dairy products 传统乳制品中发酵乳酸杆菌YSC5001抗骨质疏松活性及机制分析

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-22 DOI: 10.1016/j.jff.2025.106905

Shuo Liu , Yun Xie , Chenyu Li , Guangming Zhang , Xin Wang , Huarui Zhao , Hui Chang , Baochao Hou , Wei-Lian Hung , Jian He , Baolei Li , Zisheng Guo , Yanmei Sun , Shiwei Wang

{"title":"Anti-osteoporosis activity and mechanism analyses of Limosilactobacillus fermentum YSC5001 from Chinese traditional dairy products","authors":"Shuo Liu , Yun Xie , Chenyu Li , Guangming Zhang , Xin Wang , Huarui Zhao , Hui Chang , Baochao Hou , Wei-Lian Hung , Jian He , Baolei Li , Zisheng Guo , Yanmei Sun , Shiwei Wang","doi":"10.1016/j.jff.2025.106905","DOIUrl":"10.1016/j.jff.2025.106905","url":null,"abstract":"<div><div>Osteoporosis is prevalent, poses significant health risks, and is often overlooked in public health. Lactic acid bacteria (LAB) have emerged as a promising alternative for osteoporosis prevention, especially given the adverse effects of conventional treatments. In this study, <em>Limosilactobacillus fermentum</em> YSC5001 was identified as the most effective strain among 64 edible LAB isolates for enhancing pre-osteoblastic MC3T3-E1 cell differentiation and mineralization. Using a tail-suspended rat model, YSC5001 increased bone mineral density by 63.10 % and reduced osteoclastogenesis by 54.65 %. It also improved biomechanical properties and lowered inflammatory markers, with IL-1β and TNF-α levels decreasing by 21.41 % and 30.08 %, respectively. Further analysis suggested that YSC5001 modulates the Wnt/β-catenin pathway via secretion of 2-hydroxy-3-methylbutyric acid, arginine, and lysine, thereby alleviating osteoporosis. Notably, YSC5001 is a food-derived strain with demonstrated safety and no detectable virulence or antibiotic resistance genes, supporting its application as an oral probiotic for osteoporosis management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106905"},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-hyperuricemic effects of Philadelphus tenuifolius extract in potassium oxonate-induced hyperuricemic rats 黄连提取物对氧酸钾诱导的高尿酸血症大鼠的抗高尿酸作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-22 DOI: 10.1016/j.jff.2025.106904

Yoon-Young Sung , Dong-Seon Kim , Seung-Hyung Kim , Heung Joo Yuk

{"title":"Anti-hyperuricemic effects of Philadelphus tenuifolius extract in potassium oxonate-induced hyperuricemic rats","authors":"Yoon-Young Sung , Dong-Seon Kim , Seung-Hyung Kim , Heung Joo Yuk","doi":"10.1016/j.jff.2025.106904","DOIUrl":"10.1016/j.jff.2025.106904","url":null,"abstract":"<div><div>Hyperuricemia, characterized by elevated serum urate levels, is a major risk factor for gout and renal disorders, and cardiovascular disease. Young leaves of <em>Philadelphus tenuifolius</em> (PT) are edible, non-toxic, and used in traditional medicine and food, but their effects have not been reported. This study investigated the inhibitory activity of PT leaf ethanolic extract on hyperuricemia. Male Sprague-Dawley rats were divided into six groups: normal, hyperuricemia model, positive controls (benzobromarone and allopurinol), and two PT extract doses. Hyperuricemia was induced using potassium oxonate. PT extract significantly downregulated inflammatory markers (IL-1β, TNF-α, COX-2) in the kidney, reduced serum uric acid and creatinine, and improved renal damage. It inhibited hepatic xanthine oxidase activity and enhanced uric acid excretion by modulating renal urate transporters: decreased GLUT9 and URAT1, increased OAT1 and ABCG2. These findings suggest PT extract may ameliorate hyperuricemia and protect kidneys, supporting its potential as a functional food or therapeutic agent without any toxicity in humans.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106904"},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling amino acid sequence features that confer high calcium-binding capacity to soybean peptides and improve absorption in caco-2 cells 揭示氨基酸序列特征，赋予高钙结合能力的大豆肽和提高吸收在caco-2细胞

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-22 DOI: 10.1016/j.jff.2025.106898

Jiulong An , Manqun Wang , Wanlu Liu , Yumei Wang , Na Ma , Mingzhen Zhang , Lu Li , Chenchen Liu , Xinqi Liu , He Li

{"title":"Unraveling amino acid sequence features that confer high calcium-binding capacity to soybean peptides and improve absorption in caco-2 cells","authors":"Jiulong An , Manqun Wang , Wanlu Liu , Yumei Wang , Na Ma , Mingzhen Zhang , Lu Li , Chenchen Liu , Xinqi Liu , He Li","doi":"10.1016/j.jff.2025.106898","DOIUrl":"10.1016/j.jff.2025.106898","url":null,"abstract":"<div><div>Structure–activity relationship of food-derived peptides is a hotspot for nutrient interactions. Some studies have also improved the ability of these chelates to promote calcium absorption. However, whether the structures enabling calcium binding also influence absorption has not been studied in detail. Our previous research found that structural features, such as aspartic acid near the center of the N-terminal or consecutive aspartic acids, enhancing peptide calcium-binding capacity. Although the GGDLVS peptide exhibits these features, its effect on calcium absorption remains unclear. This study investigated chelates derived from peptides with or without these structures. The results indicated that chelates with this structure more effectively promoted Caco-2 cell calcium absorption and upregulated calcium channel protein TRPV6 expression. Molecular docking showed that the structure promoted protein interaction, facilitating calcium accumulation at the channel entry. Molecular dynamics simulations showed that the chelate structure promoted protein activation, stabilized conformation, and increased subsequent hydrogen bond formation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106898"},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0