Journal of Functional Foods最新文献

Andrographolide protects against the intestinal barrier dysfunction and inflammatory response through modulating ETEC virulence factors in a mouse model of diarrhea 穿心莲内酯在腹泻小鼠模型中通过调节 ETEC 毒力因子防止肠屏障功能紊乱和炎症反应

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-17 DOI: 10.1016/j.jff.2024.106568

Peng Wang , Aoshuang Fan , Jinduo Zhao , Yangming liu , Lin Feng , Fangyu Xia , Yuting Tian , Liping Gan , Hanzhen Qiao , Erzhen Duan , Jin Huang , Sen lin , Jinrong Wang

{"title":"Andrographolide protects against the intestinal barrier dysfunction and inflammatory response through modulating ETEC virulence factors in a mouse model of diarrhea","authors":"Peng Wang , Aoshuang Fan , Jinduo Zhao , Yangming liu , Lin Feng , Fangyu Xia , Yuting Tian , Liping Gan , Hanzhen Qiao , Erzhen Duan , Jin Huang , Sen lin , Jinrong Wang","doi":"10.1016/j.jff.2024.106568","DOIUrl":"10.1016/j.jff.2024.106568","url":null,"abstract":"<div><div>Infectious diarrhea is a common disease that endanger both human and livestock animals. However, there are limited safety strategy for preventing Enterotoxigenic <em>Escherichia coli</em> (ETEC) induced diarrhea. A mouse diarrhea model was established by orally administering ETEC following andrographolide pretreatment. Pretreatment with andrographolide improved the body weight losses, diarrhea, intestinal barrier dysfunction and inflammation of ETEC infected mice. Andrographolide pretreatment protected against the ETEC-induced downregulation of intestinal Na<sup>+</sup>/H<sup>+</sup> exchange protein 3 (Nhe3) and upregulation of cystic fibrosis transmembrane conductance regulator (Cftr) mRNA expression. Andrographolide pretreatment also reduced coliform colonization in the jejunum but did not affect fecal coliform levels in infected mice. By using an <em>in vitro</em> model, it was shown that andrographolide downregulated the expression of virulence factors involved in ETEC k88 colonization, as well as heat-labile and heat-stable enterotoxins. These results unveil a novel finding that andrographolide protect against ETEC infection by regulating its virulence factors.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106568"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-theanine enhances the improvements of EGCG on glucose and lipid metabolism disorders in obese rats L -茶氨酸能增强 EGCG 对肥胖大鼠葡萄糖和脂质代谢紊乱的改善作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-17 DOI: 10.1016/j.jff.2024.106580

Guohuo Wu , Tingting Han , Mengdi Wang , Zhaofeng Du , Zhongwen Xie , Wei Gu

{"title":"L-theanine enhances the improvements of EGCG on glucose and lipid metabolism disorders in obese rats","authors":"Guohuo Wu , Tingting Han , Mengdi Wang , Zhaofeng Du , Zhongwen Xie , Wei Gu","doi":"10.1016/j.jff.2024.106580","DOIUrl":"10.1016/j.jff.2024.106580","url":null,"abstract":"<div><div>Epigallocatechin gallate (EGCG) and L-theanine (LTA) are two key bioactive components of tea that modulate nutrient metabolism. However, whether the combination of EGCG and LTA will result in synergistic benefits for glucose and lipid metabolism disorders is still unclear. Here, we treated leptin receptor-knockout (Lepr-KO) rats with EGCG and EGCG combined with LTA to examine how combined EGCG and LTA affect glucose and lipid metabolism disorders. Our data suggested that EGCG or EGCG plus LTA all significantly reduced serum triglycerides, total cholesterol, random blood glucose, and increased glucose tolerance, as well as alleviated fatty liver formation in Lepr-KO rats. Moreover, compared with EGCG alone, EGCG plus LTA significantly reduced random blood glucose and plasma triacylglycerols (TG) levels, and alleviated hepatic steatosis. Mechanistic analysis revealed that EGCG plus LTA improved glucose metabolism disorders by activating hepatic glucokinase (GCK) and glycogen synthase 2 (GYS2) expression, and inhibited fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1) for lowering hepatic TG accumulation. This study demonstrated that LTA enhances the improvements of EGCG on glucose and lipid metabolism disorders in Lepr-KO rats, especially in glycometabolism.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106580"},"PeriodicalIF":3.8,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application and mechanism of natural products and nutrient elements in COVID-19 天然产品和营养元素在 COVID-19 中的应用和机理

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-17 DOI: 10.1016/j.jff.2024.106561

Lin Zhou, Yulin Tan, Lei Shi, Weibin Bai, Xiaoling Li

引用次数: 0

BDNF-mediated regulation of GSK-3β and PSD95 phosphorylation in anti-depressive effects of Capsosiphon fulvescens glycoproteins against chronic alcohol exposure BDNF 介导的 GSK-3β 和 PSD95 磷酸化调控对 Capsosiphon fulvescens 糖蛋白抗慢性酒精暴露的抑郁作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-16 DOI: 10.1016/j.jff.2024.106571

Jeong Hwan Oh, Taek-Jeong Nam

{"title":"BDNF-mediated regulation of GSK-3β and PSD95 phosphorylation in anti-depressive effects of Capsosiphon fulvescens glycoproteins against chronic alcohol exposure","authors":"Jeong Hwan Oh, Taek-Jeong Nam","doi":"10.1016/j.jff.2024.106571","DOIUrl":"10.1016/j.jff.2024.106571","url":null,"abstract":"<div><div>Hydrophilic glycoproteins from the alga <em>Capsosiphon fulvescens</em> (Cf-hGP) enhance spatial memory and reduce depression-like behavior in aging rats. However, their effects on ethanol-induced depression-like behavior in adolescent rats and underlying mechanisms remain unclear. This study investigated the neuroprotective effects of Cf-hGP in mitigating depression-like behavior caused by chronic alcohol administration (2 g/kg, 4 weeks) in rats, focusing on molecular changes in the ventral hippocampus. Chronic alcohol exposure increased glucose-regulated protein 78 (an ER stress marker), while decreasing brain-derived neurotrophic factor (BDNF) and phosphorylation of glycogen synthase kinase 3-beta (GSK-3β; Ser9) and postsynaptic density protein 95 (PSD95; Ser295). Cf-hGP administration (10 mg/kg/d) reversed these effects, restoring GSK-3β and PSD95 phosphorylation. Blockade of BDNF signaling suppressed Cf-hGP’s effects, confirming its role in BDNF-mediated neuroprotection. Cf-hGP also reduced alcohol-induced depression-like behavior, suggesting its potential as a therapeutic agent for alcohol-induced depression via modulation of ER stress and BDNF signaling pathways.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106571"},"PeriodicalIF":3.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2′-Fucosyllactose improved muscle health in middle-aged mice performing forced swimming exercise 2′-岩藻糖半乳糖能改善进行强迫游泳运动的中年小鼠的肌肉健康状况

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-15 DOI: 10.1016/j.jff.2024.106567

Jae Kwang Kim , Chul Soo Shin , Jong-Won Yoon , Seon-Min Jeon , Jeongsu Bang , Sae Kwang Ku , Kyung Hwan Jegal

{"title":"2′-Fucosyllactose improved muscle health in middle-aged mice performing forced swimming exercise","authors":"Jae Kwang Kim , Chul Soo Shin , Jong-Won Yoon , Seon-Min Jeon , Jeongsu Bang , Sae Kwang Ku , Kyung Hwan Jegal","doi":"10.1016/j.jff.2024.106567","DOIUrl":"10.1016/j.jff.2024.106567","url":null,"abstract":"<div><div>Muscle mass and strength gradually decline from middle age, and appropriate physical activity and exercise habits during this period play a key role in preventing sarcopenia. Exercise is the most effective method for improving muscle health, and consuming appropriate dietary supplements along with exercise can boost its effects. Human milk is the most essential source for muscle growth during infancy, and 2′-fucosyllactose (2′-FL) is most abundant oligosaccharide in human milk. Therefore, we hypothesized that 2′-FL would exhibit muscle protective properties in 10-month-old aged male mice subjected to forced swimming exercises. Our findings revealed that 2′-FL administration significantly improved muscle mass, thickness, and strength of calf muscle compared to forced swimming exercise alone. Additionally, 2′-FL enhanced the hypertrophic changes in gastrocnemius and soleus. Furthermore, 2′-FL upregulated gene expression related to muscle protein synthesis (<em>PI3K, AKT1</em>) and muscle growth (<em>A1R, TRPV4</em>), while inhibiting gene expression related to muscle protein degradation (<em>Atrogin-1, MuRF-1</em>) and muscle growth inhibition (<em>Myostatin, SIRT1</em>). 2′-FL also ameliorated exercise-induced oxidative stress, restored antioxidant enzyme activity, and mitigated muscular cell damage. These findings suggest that 2′-FL may serve as a functional dietary supplement combined with exercise for muscle health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106567"},"PeriodicalIF":3.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the Nrf2/GPX4 signaling axis 榛叶多酚通过 Nrf2/GPX4 信号轴调节尿酸代谢和抑制铁卟啉沉积，从而改善高尿酸血症诱发的肾脏纤维化

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-14 DOI: 10.1016/j.jff.2024.106579

Xinhe Wang, Xiaowen Li, Jiarui Zhao, Zhi Lin, Jun Li, Xinyi Xu, Xinrui Zhou, Yuchen Wang, Guangfu Lv, He Lin, Zhe Lin

{"title":"Hazel leaf polyphenols ameliorate hyperuricemia-induced renal fibrosis through regulating uric acid metabolism and inhibiting ferroptosis via the Nrf2/GPX4 signaling axis","authors":"Xinhe Wang, Xiaowen Li, Jiarui Zhao, Zhi Lin, Jun Li, Xinyi Xu, Xinrui Zhou, Yuchen Wang, Guangfu Lv, He Lin, Zhe Lin","doi":"10.1016/j.jff.2024.106579","DOIUrl":"10.1016/j.jff.2024.106579","url":null,"abstract":"<div><div>Hazel leaves, a by-product of hazelnut, have been consumed for health care in some countries and regions for hundreds of years. Based on our previous results, this study further investigated the protective effects of hazel leaf polyphenols (HP) on renal fibrosis induced by hyperuricemia in mice. Results showed that they significantly reduced serum UA, BUN and CRE contents, inhibited liver XOD activity. Histological examination and Western blot analysis revealed that they renal pathological changes and fibrosis were obviously improved after HP administration. Additionally, combined with TEM, they attenuated oxidative stress and mitochondrial damage, and inhibited ferroptosis by regulating the expression of related proteins. Molecular docking predicted that chlorogenic acid, p-coumaric acid, luteolin, myricetin and kaempferol may be the key active ingredients. In conclusion, HP ameliorated hyperuricemia-induced renal fibrosis through regulating uric acid production, reabsorption and excretion, and inhibiting ferroptosis through Nrf2/GPX4 signaling axis. It provides a valuable basis for the utilization of hazel leaf polyphenols as health agents in the future.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106579"},"PeriodicalIF":3.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of sesamin on sleep quality and the antioxidative status in patients with low arousal threshold obstructive sleep apnea syndrome and those at risk of obstructive sleep apnea syndrome 芝麻素对低唤醒阈阻塞性睡眠呼吸暂停综合征患者和阻塞性睡眠呼吸暂停综合征高危人群睡眠质量和抗氧化状态的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-14 DOI: 10.1016/j.jff.2024.106564

Lu-Chi Fu , Wen-Te Liu , Hitoshi Shirakawa , Yi-Hsiu Chen , Qian Xiao , Suh-Ching Yang

{"title":"Effects of sesamin on sleep quality and the antioxidative status in patients with low arousal threshold obstructive sleep apnea syndrome and those at risk of obstructive sleep apnea syndrome","authors":"Lu-Chi Fu , Wen-Te Liu , Hitoshi Shirakawa , Yi-Hsiu Chen , Qian Xiao , Suh-Ching Yang","doi":"10.1016/j.jff.2024.106564","DOIUrl":"10.1016/j.jff.2024.106564","url":null,"abstract":"<div><div>This study aims to investigate the beneficial effects of sesamin (94.0 mg/day) on sleep quality and antioxidative status in patients at risk of obstructive sleep apnea syndrome (OSAS) or those with a low arousal threshold for OSAS. It is a double-blind, self-controlled, crossover study. After 8-week sesamin supplementation, Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) scores significantly decreased, indicating improved sleep quality and reduced daytime sleepiness symptoms. Furthermore, the antioxidant status was significantly enhanced, including elevation of glutathione peroxidase (GPX) and glutathione reductase activities, and the glutathione content, alongside a reduction in the plasma malondialdehyde content. Results of correlation analysis showed that plasma GPX activity was negatively correlated with PSQI and ESS scores, suggesting that the oxidative stress status might be related to improvements in subjective sleep quality.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106564"},"PeriodicalIF":3.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jinhua Hecha – A fermented green tea improves sleep via regulating glutamatergic synapses and gut microbiota 金华黑茶--一种通过调节谷氨酸能突触和肠道微生物群改善睡眠的发酵绿茶

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106550

Yingying Wang , Xunjie Zheng , Ke Li , Jianli Gao , Jianbo Huang , Zhaohuan Lou

{"title":"Jinhua Hecha – A fermented green tea improves sleep via regulating glutamatergic synapses and gut microbiota","authors":"Yingying Wang , Xunjie Zheng , Ke Li , Jianli Gao , Jianbo Huang , Zhaohuan Lou","doi":"10.1016/j.jff.2024.106550","DOIUrl":"10.1016/j.jff.2024.106550","url":null,"abstract":"<div><div>Quality sleep is crucial for preserving the internal equilibrium of the body. Sleep problems have become a predominant global health concern in recent years. Jinhua Hecha (JHHC) is a fermented green tea characterized by high amino acid and low tea polyphenols. In animal experiments, the potential beneficial effects of JHHC on sleep quality were evaluated. 50 mice were categorized into five groups: the normal control (NC) group, the FFZR positive control group, the JHHCG (2.3 g/kg) group, the JHHCZ (1.6 g/kg) group, and the JHHCD (0.7 g/kg) group. The sleep experiments revealed that mice from the JHHC group exhibited a notably extended duration of sleep following the intraperitoneal injection of pentobarbital sodium, with a shortened sleep latency after injection of barbital sodium. These results suggest that JHHC is beneficial for sleep. Mechanistically, transcriptome KEGG enrichment analysis revealed that differentially expressed genes were significantly enriched in the glutamatergic synapse signaling pathway. Immunohistochemistry and multiple immunofluorescence techniques showed decreased protein expressions of GLS, VGLUT2, GluA2, GluA4, GluK1, and mGluR1 in the colon of the JHHC group. Furthermore, an increase in beneficial bacteria such as Lactobacillus, Ligilactobacillus, and Akkermansia, as well as a decrease in Alistipes, were observed in the JHHC group. These results indicate that JHHC can improve sleep, with potential mechanisms involving gut microbiota maintenance and glutamate level reduction.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106550"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway 萎缩性真菌（无柄灵芝）通过下调CCL28/CCR10通路抑制肿瘤微环境中Treg的招募

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106573

Lu Jin , Jianhui Fu , Xiaochen Lin , Lushuai Jin , Yingxue Guo , Xia Liu , Shaden A.M. Khalifa , Hesham R. El-Seedi , Huiying Fu , Qiyang Shou

{"title":"Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway","authors":"Lu Jin , Jianhui Fu , Xiaochen Lin , Lushuai Jin , Yingxue Guo , Xia Liu , Shaden A.M. Khalifa , Hesham R. El-Seedi , Huiying Fu , Qiyang Shou","doi":"10.1016/j.jff.2024.106573","DOIUrl":"10.1016/j.jff.2024.106573","url":null,"abstract":"<div><div><em>Ganoderma sessile</em>, a saprophytic fungus, is a traditional Chinese medicinal material used in Chinese folk medicine and cuisine for its potential to enhance cancer patients immunity in clinical practice. However, the underlying mechanisms of its therapeutic effects remain elusive. Therefore, we explored the edible value to determine the underlying mechanisms of GS through multiple breast cancer models. GS was found to suppress tumor growth and lung metastasis, and prolong survival after surgery. It significantly increased tumor-infiltrating CD44<sup>Hi</sup>CD62L<sup>Hi</sup>CD8<sup>+</sup> T<sub>CM</sub> cells while decreasing CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>−</sup> Treg cells in both lymph nodes and tumors. The mechanism behind GS’s effects primarily involved modulation of the Hif1-a/CCL28 pathway associated with Treg recruitment. Furthermore, GS could reduce CCR10 levels on the surface of Tregs. Collectively, GS inhibits tumor growth and pulmonary metastasis by restraining Treg recruitment through downregulation of the CCL28/CCR10 pathway—a finding which highlights its potential as a natural anti-tumor immune agent warranting further exploration.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106573"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tea intervention ameliorated metabolic dysfunction caused by circadian rhythm disorders via gut microbiota-bile acid-FXR axis 茶干预通过肠道微生物群-胆汁酸-FXR 轴改善昼夜节律紊乱引起的代谢功能障碍

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106566

Yang Wei, Siwei Miao, Kang Wei, Lanlan Peng, Xinlin Wei

{"title":"Tea intervention ameliorated metabolic dysfunction caused by circadian rhythm disorders via gut microbiota-bile acid-FXR axis","authors":"Yang Wei, Siwei Miao, Kang Wei, Lanlan Peng, Xinlin Wei","doi":"10.1016/j.jff.2024.106566","DOIUrl":"10.1016/j.jff.2024.106566","url":null,"abstract":"<div><div>With the rapid development of society and changing lifestyles, people often encounter circadian rhythm disorder (CRD). Although tea active components have shown promise in improving CRD, a comprehensive comparison of different types of tea in improving CRD is still lacking, and the mechanism of regulating CRD-induced metabolic disorders remained unclear. This study selected three representative teas (Green tea, black tea, and dark tea) and compared the ameliorative effects of different teas on CRD-induced metabolic dysfunction. Furthermore, tea intervention improved the metabolic syndrome associated with CRD mainly through decreasing relative abundance of BSH-producing microbes, increasing conjugated bile acids (BAs) that act in an antagonistic manner on intestinal farnesoid X receptor (FXR), and promoting elimination of BAs via the feces. Our results shed light into the mechanisms behind the ameliorative effect of tea intervention on metabolic dysfunction caused by CRD, and suggest that the gut microbiota-bile acid-FXR axis may be potential therapies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106566"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0