Journal of Functional Foods最新文献

{"title":"Impact of black soybean peptides on intestinal barrier function and gut microbiota in hypertensive mice","authors":"Dawei Cheng ,&nbsp;Xinyu Huang ,&nbsp;Caihong Zhang ,&nbsp;Ben Shao ,&nbsp;Xueling Li ,&nbsp;Meiqing Li","doi":"10.1016/j.jff.2024.106608","DOIUrl":"10.1016/j.jff.2024.106608","url":null,"abstract":"<div><div>The aim of the present study was to examine the antihypertensive effect of black soybean peptides (BSP) and investigate the role of these peptides in ameliorating hypertension-induced intestinal damage and modulating gut microbiota. The findings demonstrated that BSP could significantly reduce the blood pressure of mice with diet-induced hypertension (<em>P</em> &lt; 0.001). Simultaneously, BSP effectively inhibited the production of pro-inflammatory factors (IL-17 and TNF-α) and increased the levels of an anti-inflammatory factor (IL-10) in the colon of mouse models of hypertension. Additionally, BSP up-regulated the gene expression of intestinal barrier factors <em>ZO-1</em>, <em>Occludin</em>, and <em>MUC-2</em>, and alleviated the hypertension-induced inflammatory infiltration of colon tissue. Furthermore, the peptides increased the levels of short-chain fatty acids (SCFAs) in the feces and up-regulated the protein expression of the SCFA receptor GPR41/43. The analysis of intestinal microbes showed that BSP could modulate the richness and diversity of the intestinal microbiota in mouse models of hypertension, increase the abundance of beneficial bacteria, decrease the abundance of harmful bacteria, and promote the homeostasis of the imbalanced intestinal microbiota. Notably, BSP exerted a significant protective effect against L-NAME-induced hypertension in mice, demonstrating good outcomes with respect to blood pressure regulation, intestinal protection, and intestinal microbiota balance. Therefore, BSP may ameliorate the harm caused by hypertension and could aid in the prevention of hypertension as a dietary intervention.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106608"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of milk powder fortified with red ginseng extracts on the skin barrier function and immunity of middle-aged women","authors":"Yao Ge ,&nbsp;Wenhui Ye ,&nbsp;Yue Wang ,&nbsp;Aiqin Ma ,&nbsp;Man Wang ,&nbsp;Qingshan Chen ,&nbsp;Xiaoyan Huo ,&nbsp;Chunxi Liu ,&nbsp;Yujie Shi ,&nbsp;Biao Liu ,&nbsp;Wei Chen","doi":"10.1016/j.jff.2024.106613","DOIUrl":"10.1016/j.jff.2024.106613","url":null,"abstract":"<div><div>This study investigated the effects of a nutritional milk composition containing red ginseng extract (MCCRG) on the skin barrier function and immunity of middle-aged women. Fifty women (aged, 25 to 45) consumed MCCRG orally for 56 days. Evaluations of skin phenotype, facial bacterial microbiome, immune system function, and clinical diagnoses were conducted. The results indicated that MCCRG significantly improved skin hydration, firmness, elasticity, and glossiness. Furthermore, MCCRG also reduced TEWL and wrinkles and enhanced skin barrier integrity. Additionally, high IgG levels and improved CD4+/CD8+ ratios due to MCCRG consumption increased facial microbiota diversity and immune function. Clinical diagnoses provided supplementary evidence for the efficacy of MCCRG. The findings of this study demonstrated that MCCRG, through nutritional support, enhanced both skin barrier and immune system functions. This study offers substantial evidence of the innovative therapeutic effects of nutritional support on skin barrier damage and immune function.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106613"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safflower petal water-extract consumption reduces blood glucose via modulating hepatic gluconeogenesis and gut microbiota","authors":"Cong Yin ,&nbsp;Rui Fang ,&nbsp;Yue Xu ,&nbsp;Kui Li ,&nbsp;Tingyang Ai ,&nbsp;Jiawei Wan ,&nbsp;Yonghua Qin ,&nbsp;Xiaoguang Lyu ,&nbsp;Hong Liu ,&nbsp;Rui Qin ,&nbsp;Lindong Yang ,&nbsp;Hairong Xiong ,&nbsp;Jiao Liu","doi":"10.1016/j.jff.2024.106615","DOIUrl":"10.1016/j.jff.2024.106615","url":null,"abstract":"<div><div>Safflower is a widely utilized food and medicinal herb. The safflower petal is often used for tea-making or food colorant since the water-extract contains a lot of biologically active ingredients. This study aimed to evaluate the impacts of safflower petal water-extract (SE) on blood glucose regulation. The results demonstrated that both long-term and acute consumption of SE ameliorated the blood glucose regulation successfully. Mechanistically, SE suppressed the hepatic gluconeogenesis, which was involved with the protein kinase B (AKT)/forkhead transcription factor 1 (FoxO1) signaling pathway. In addition, SE modulated the gut microbiota that is related to host glucose regulation. Finally, drinking safflower petal-tea could efficiently decrease the healthy participants' blood glucose at two hours after breakfast. Hence, this study proved that drinking safflower petal-tea can be a feasible way to maintain stable blood glucose, and SE can be used as a potential function food ingredient for the prevention and amelioration of hyperglycemia.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106615"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-depth genomic identification and safety evaluation of Lactobacillus Acidophilus LA85","authors":"Yongmei Qi ,&nbsp;Yao Dong ,&nbsp;Jiayue Gu ,&nbsp;Yihui Cai ,&nbsp;Yanyan Zhang ,&nbsp;Zhonghui Gai ,&nbsp;Mei Han","doi":"10.1016/j.jff.2024.106604","DOIUrl":"10.1016/j.jff.2024.106604","url":null,"abstract":"<div><div>In vitro tests assessed heat tolerance, bile salt hydrolysis, intestinal adhesion, gastrointestinal environmental tolerance, hemolysis, gelatin hydrolysis, antibiotic sensitivity, inhibition of pathogenic bacteria, and toxicity of <em>Lactobacillus acidophilus</em> LA85. The safety of LA85 was verified by acute oral toxicity test. Genome analysis revealed no virulence, pathogenicity, or biogenic amine synthesis genes in LA85, but one drug resistance gene. LA85 displayed strong heat tolerance, intestinal adhesion, and gastrointestinal environment tolerance, with bile salt and gelatin hydrolysis abilities, and no hemolysis. It was sensitive to European Food Safety Authority proposed antibiotics, had inhibitory effects on common pathogenic bacteria, and both its fermentation broth and cells were non-toxic. Acute oral toxicity test confirmed that LA85 (2 × 10¹⁰ CFU/kg) was safe and non-toxic in mice. The safety evaluation presented in this paper firmly establishes LA85 as a safe and effective probiotic candidate for use in a wide range of food and medical applications.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106604"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parabiotic immunomodulatory activity of yeast cell wall polysaccharides from Saccharomyces cerevisiae and S. boulardii","authors":"Kwang-Rim Baek ,&nbsp;Hyun-Ji Lee ,&nbsp;Kang-Hyeon Jeong ,&nbsp;Bo-Ram Park ,&nbsp;Soo-Jung Kim ,&nbsp;Seung-Oh Seo","doi":"10.1016/j.jff.2024.106577","DOIUrl":"10.1016/j.jff.2024.106577","url":null,"abstract":"<div><div>Yeast, particularly <em>Saccharomyces cerevisiae</em>, is widely regarded as a nutritional supplement in the food and feed industries. Notably, <em>Saccharomyces boulardii</em> is promoted as a probiotic strain for its efficacy in gastrointestinal disorders. Despite genetic similarities to <em>S. cerevisiae</em>, <em>S. boulardii</em> is distinguished from <em>S. cerevisiae</em> by unique features like cell wall composition, which is crucial for immune activation. This study evaluated the cell wall polysaccharide contents of <em>S. boulardii</em> and <em>S. cerevisiae</em> and their immunomodulatory activity on Raw 264.7 cell. Results showed an increased secretion of pro-inflammatory factors (TNF-α, IL-6, and NO) and the anti-inflammatory factor IL-10. Remarkably <em>S. boulardii</em> cell extracts had a more pronounced effect than <em>S. cerevisiae</em> cell extracts. The immunomodulatory activity is linked to the MAPK(ERK)/NF-κB pathway, activated by β-glucan and mannan via Dectin-1 and Dectin-2 receptors. This difference in immune response are attributed to variations in content of mannan and β-glucan in their cell walls.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106577"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish collagen peptides supplementation ameliorates skeletal muscle injury in high-fat diet mice associated with thyroid function recovery","authors":"Yuhui Yang ,&nbsp;Hao Yang ,&nbsp;Xu Tian ,&nbsp;Wenhan Jian ,&nbsp;Nazish Muzaffar ,&nbsp;Guowei Le ,&nbsp;Yanli Xie ,&nbsp;Peng Li ,&nbsp;Yuncong Xu","doi":"10.1016/j.jff.2024.106612","DOIUrl":"10.1016/j.jff.2024.106612","url":null,"abstract":"<div><div>This study aims to explore the effects of fish collagen peptides (FCP) supplementation on skeletal muscle injury in high-fat (HF) diet mice and their possible mechanisms. Experimental mice were fed a normal diet (4 % fat), HF diet (20 % fat), or FCP diet (20 % fat and 1 % FCPs) for 22 consecutive weeks. Results show that FCP supplementation improves skeletal muscle motor function and histomorphology, and lipid levels; promotes protein synthesis, and inhibits protein degradation in skeletal muscle. Moreover, FCP supplementation also improves mitochondrial biogenesis, promotes energy metabolism and ATP production. Furthermore, FCP supplementation increases antioxidant defenses in the thyroid and skeletal muscle, improves thyroid morphological structure, promotes the synthesis and secretion of thyroid hormones, and enhances the actions of thyroid hormones on its receptor organ skeletal muscle. Cumulatively, these findings indicate that FCP supplementation can alleviate skeletal muscle injury induced by an HF diet associated with thyroid function recovery.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106612"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lily extract ameliorate mouse pneumonia by modulating ciliary function","authors":"Zengkun Sun ,&nbsp;Dongfeng Xu ,&nbsp;Xiaoru Wang ,&nbsp;Jie Zhou ,&nbsp;Ning Xiao ,&nbsp;Ruilei Jia ,&nbsp;Diyi Huang ,&nbsp;Dongqi Tang ,&nbsp;Tao Xia ,&nbsp;Fang Xiao","doi":"10.1016/j.jff.2024.106603","DOIUrl":"10.1016/j.jff.2024.106603","url":null,"abstract":"<div><div>This study explores the biological effects and mechanisms of Lily extract on LPS-induced pneumonia mice. Research has found that after 48 h of treatment with low-dose and high-dose lily extract (100 mg/kg, 200 mg/kg), there was a significant reduction in inflammatory cell infiltration, mRNA expression levels of pro-inflammatory factors (<em>IL-6, IL-1β, TNF-α</em>), protein levels of inflammation-related proteins (IL-6, NF-κB P65) in the lung tissue. In addition, lily extract significantly improved the function of cilia assembly and movement. The expression levels of cilia-related genes (<em>Ttc21a, Cfap45,</em> etc.) and proteins were significantly upregulated. Among them, the high-dose treatment group had tightly arranged cilia and good growth conditions, which was significantly better than the LPS pneumonia model and low-dose treatment group. This found providing novel insights into the pathogenesis and progression of pneumonia. This has important implications for the prevention and treatment of pneumonia, as well as the development of natural agents.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106603"},"PeriodicalIF":3.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids from Ougan (Citrus suavissima Hort. ex Tanaka) peel exert hypoglycemic potency through inhibiting insulin resistance in HepG2 cells and regulating gut microbiota in diabetic mice","authors":"Hongyan Zhou ,&nbsp;Shengmin Lu ,&nbsp;Meiyu Zheng ,&nbsp;Xiaokun Ouyang","doi":"10.1016/j.jff.2024.106596","DOIUrl":"10.1016/j.jff.2024.106596","url":null,"abstract":"<div><div>To fully and value-addedly utilize the citrus peel resource, flavonoids were extracted and purified from peel powder of Ougan (<em>Citrus suavissima</em> Hort. ex Tanaka) using an ultrasonic assisted ethanol solution extraction method and AB-8 macroporous resin purification. The obtained flavonoid extract from peel of Ougan (FEPO) was used for the hypoglycemic experiments <em>in vitro</em> and <em>in vivo</em> on glucose consumption in insulin resistance model HepG2 cells and streptozotocin induced diabetes model mice. A significant reduction of glucose consumption in the model cells while a significant increase in the treated were found in a dose-dependent manner, compared to 5.2241 ± 0.2201 mmol/L of the normal cells (<em>P</em> &lt; 0.05). When the FEPO concentration was 80 μg/mL, the cell glucose consumption was 4.4055 ± 0.1772 mmol/L. Compared with those in the model group (diabetic mice), the fasting blood glucose in the FEPO intervened mice was significantly decreased (<em>P</em> &lt; 0.05). FEPO intervention caused decreased levels of TC, TG, LDL-C, and increased HDL-C and insulin contents in the serums as well as ameliorative histopathology of the liver, kidney, and pancreas in diabetic mice. FEPO improved the gut microbiota structure of diabetic mouse by regulating its composition, especially significantly increasing the relative abundance of <em>Lactobacillus</em>, <em>Ileibacterium</em>, <em>unclassified_f_Lachnospiracea</em>, <em>Romboutsia</em>, <em>norank_f_Muribaculaceae</em>, <em>Faecalibaculum</em> and <em>Coriobacteriaceae_UCG-002</em> (<em>P</em> &lt; 0.05), while decreasing that of <em>norank_f_norank_o_Clostridia_UCG-014</em>, <em>Lachnospiraceae_NK4A136_group</em> and <em>Candidatus_Saccharimonas</em>. In conclusion, FEPO had good hypoglycemic efficacies both <em>in vitro</em> and <em>in vivo</em> as well as gut microbiota regulating effect.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106596"},"PeriodicalIF":3.8,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreeability and gastrointestinal motility responses to fully characterized experimental pasta enriched in wheat by-products","authors":"Mirco Vacca ,&nbsp;Mohamad Khalil ,&nbsp;Antonio Rampino ,&nbsp;Giuseppe Celano ,&nbsp;Elisa Lanza ,&nbsp;Giusy R. Caponio ,&nbsp;Felice Ungaro ,&nbsp;Alessandro Bertolino ,&nbsp;Agostino Di Ciaula ,&nbsp;Maria De Angelis ,&nbsp;Piero Portincasa","doi":"10.1016/j.jff.2024.106598","DOIUrl":"10.1016/j.jff.2024.106598","url":null,"abstract":"<div><div>Pasta, a Mediterranean diet staple, enhances well-being when enriched with healthy ingredients like durum wheat-germ (WG) and wheat-bran (WB). We studied the nutritional and clinical responses to four experimental pastas (EP1-EP4) made with de-oiled WG, WB, and microencapsulated durum wheat-oil (mWO), compared to a control pasta of water and semolina dough. WG addition significantly boosted total phenols and radical scavenging activity. Simulated colonic fermentation showed WG-enriched pasta enhanced short-chain fatty acids production.</div><div>The clinical response to pasta was studied in 70 healthy subjects by semiquantitative scales of sensory perception, functional ultrasonography of gastric and gallbladder kinetics, and breath test for orocecal transit time. Sensory analysis revealed differences in odor, aftertaste, and overall pleasantness, especially in EP2. Gastrointestinal motility was similar across pastas, but EP3 had a shorter transit time and higher colonic fermentation. This study suggests that wheat by-products enriched pastas offer nutraceutical benefits, agreeability, digestibility, and sustainability.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106598"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vanillic acid attenuates doxorubicin-induced cardiotoxicity by regulating PINK1/Parkin/Mfn2 signaling pathway","authors":"Cheng Zhang ,&nbsp;Jiayun Guo ,&nbsp;Yimeng Li ,&nbsp;Jiuyao Zhou ,&nbsp;Jianping Song ,&nbsp;Wei Zhu ,&nbsp;Changsheng Deng ,&nbsp;Manxue Mei","doi":"10.1016/j.jff.2024.106595","DOIUrl":"10.1016/j.jff.2024.106595","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to explore the potential protective effects of vanillic acid (VA) against doxorubicin (DOX)-induced cardiotoxicity and unravel the underlying molecular mechanisms involved.</div></div><div><h3>Methods</h3><div>The DOX -induced myocardial toxicity model was established in Sprague-Dawley (SD) rats by intraperitoneal injection of doxorubicin. Simultaneously, different concentrations of VA were administered for intervention. After modeling, rat cardiac function was evaluated using an ultrasound machine. The detection of creatine kinase isoenzyme MB (CK-MB) levels in rat serum using a biochemical analyzer. HE staining method was used to observe myocardial pathological changes, Masson's trichrome staining was performed to assess the degree of myocardial fibrosis. The observation of superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) levels in myocardial tissue using assay kits. Western blotting and immunohistochemistry was conducted to detect protein expression levels of PINK1, Parkin, P62, LC3I/II, Mfn2, Drp1, OPA, and Fis1.</div></div><div><h3>Results</h3><div>Compared to the DOX group, intervention with VA demonstrates ameliorative effects on doxorubicin-induced cardiotoxicity, as evidenced by improvements in left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS), and a reduction in left ventricular end-diastolic diameter (LVEDd) in rats. Additionally, the application of VA reduced the levels of CK-MB in rat serum. However, there were no statistically significant differences observed in heart rate. Histological examination reveals that VA administration positively impacts the arrangement of myocardial fibers and mitigates myocardial fibrosis in the rat hearts subjected to doxorubicin-induced injury. Moreover, relative to the DOX group, the use of VA alleviates DOX-induced myocardial cell apoptosis. VA treatment also upregulates the expression levels of PINK1 and Parkin, leading to the activation of mitochondrial autophagy. Furthermore, VA enhances the expression levels of mitochondrial dynamics proteins Mfn2, Drp1, and Fis1 while downregulating the expression of OPA. Among them, the high-dose group of VA (60 mg/kg·d) showed the most pronounced improvement in DOX-induced cardiotoxicity.</div></div><div><h3>Conclusion</h3><div>VA attenuated DOX-induced myocardial injury by up regulating the PINK1/Parkin/Mfn2 signaling pathway.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106595"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}