Journal of Functional Foods最新文献

Proteome analysis reveals the molecular mechanisms of fucoxanthin-induced apoptosis in glial cells PC12 after nanoencapsulation

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-01 DOI: 10.1016/j.jff.2025.106710

Chunyan Wang , Xinxin Ma , Yoshimasa Nakamura , Hang Qi

{"title":"Proteome analysis reveals the molecular mechanisms of fucoxanthin-induced apoptosis in glial cells PC12 after nanoencapsulation","authors":"Chunyan Wang , Xinxin Ma , Yoshimasa Nakamura , Hang Qi","doi":"10.1016/j.jff.2025.106710","DOIUrl":"10.1016/j.jff.2025.106710","url":null,"abstract":"<div><div>Fucoxanthin (FX) is a natural pigment belonging to the xanthophyll carotenoid, which has been proven to have inhibitory effects on glioblastoma. In our previous study, nano-FX was fabricated through whey protein and flaxseed gum co-encapsulated for improved stability and glial cell (PC12) inhibitory activity of FX. To investigate the molecular mechanisms of FX-induced apoptosis in PC12 after nanoencapsulation, proteomics analysis based on TMT technology was performed. Protein profiles in PC12 were determined after 0 (Control), 8 (L_Treat), and 24 (H_Treat) μg/mL nano-FX intervention. Results indicated 78 differential abundant proteins (DAPs) linked to the cytotoxicity of nano-FX could be potential biomarkers. GO and KEGG analysis revealed altered proteasome and NF-kappa B/MAPK/TNF. Proteins involved in cell proliferation were downregulated, while proteins response to autophagy and apoptosis were upregulated. The multiple mechanisms involved in the anti-tumor activity of nano-FX will provide a reference for the development of FX high value-added functional foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106710"},"PeriodicalIF":3.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143512202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin-loaded Nanoliposomes mitigate PM10-induced lung injury by modulating Inflammasome-mediated Pyroptosis

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-01 DOI: 10.1016/j.jff.2025.106703

Hwa-Young Lee , Yun-Jo So , Geum-Hwa Lee , Gi-Hyun Jang , Do-Hyeon Kim , Myoung Ja Chung , Hyewon Lee , Yu-Mi Kim , Han-Jung Chae

引用次数: 0

Anti-aging effect of recombinant Morchella eximia immunomodulatory protein on Caenorhabditis elegans

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-26 DOI: 10.1016/j.jff.2025.106709

Jinyan Li , Jialan Zhang , Tong Gu , Li Li , Mengxiang Gao

{"title":"Anti-aging effect of recombinant Morchella eximia immunomodulatory protein on Caenorhabditis elegans","authors":"Jinyan Li , Jialan Zhang , Tong Gu , Li Li , Mengxiang Gao","doi":"10.1016/j.jff.2025.106709","DOIUrl":"10.1016/j.jff.2025.106709","url":null,"abstract":"<div><div>A fungal immunomodulatory protein (FIP) (MeIMP) was discovered in edible mushroom <em>Morchella eximia</em>. Bioinformatics analysis demonstrated that MeIMP possesses cerato-platanin domains. Phylogenetic analysis positioned MeIMP within a distinct branch of the FIP family. The <em>MeIMP</em> gene was cloned and expressed in the <em>Rosetta</em> (DE3) strain. The anti-aging effect of recombinant MeIMP (rMeIMP) was evaluated by several indicators of <em>Caenorhabditis elegans</em> (<em>C. elegans</em>). The results indicated that rMeIMP significantly prolonged the lifespan of <em>C. elegans</em>, enhanced their motility ability, and diminished lipofuscin accumulation, while not affecting reproductive ability. Under UV, high temperature, and hydrogen peroxide stress, rMeIMP also significantly prolonged survival times of <em>C. elegans</em>. Additionally, rMeIMP extended the lifespan of <em>C. elegans</em> by scavenging ROS to mitigate the detrimental effects of oxidative stress. The establishment of a prokaryotic expression system for MeIMP and the assessment of rMeIMP function provided valuable insights for the further development and utilization of MeIMP.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106709"},"PeriodicalIF":3.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-25 DOI: 10.1016/j.jff.2025.106705

Oumayma Aguerd , Hamza Elhrech , Meryem El Fessikh , Khan Wen Goh , Nasreddine El Omari , Tarik Aanniz , Abdelhakim Bouyahya

{"title":"Dietary bioactive compounds for type 2 diabetes: A comprehensive review of molecular interactions and mechanistic insights","authors":"Oumayma Aguerd , Hamza Elhrech , Meryem El Fessikh , Khan Wen Goh , Nasreddine El Omari , Tarik Aanniz , Abdelhakim Bouyahya","doi":"10.1016/j.jff.2025.106705","DOIUrl":"10.1016/j.jff.2025.106705","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is a prevalent, long-term illness that adversely impacts patients' quality of life and significantly increases the risk of severe complications. Type 2 diabetes mellitus (T2DM) accounts for approximately 90 % of global diabetes cases and is influenced by lifestyle and epigenetic factors, including dietary habits and physical inactivity. Current primary treatments involve lifestyle changes and synthetic medications, which, despite their efficacy, can result in adverse side effects and high costs. In response, there is growing interest in plant-derived bioactive compounds as alternative therapeutic options for T2DM, given their accessibility, lower cost, and reduced risk of side effects. This review comprehensively explores the pharmacological actions of natural compounds against key molecular targets implicated in T2DM pathology, such as dipeptidyl peptidase-4 (DPP4), α-amylase, α-glucosidase, peroxisome proliferator-activated receptor γ (PPARγ), protein tyrosine phosphatase-1B (PTP1B), and glucose transporter type-4 (GLUT4), along with their roles in mitigating lipotoxicity and glucotoxicity. These findings underscore the potential of bioactive compounds in developing safer and more effective T2DM management strategies, paving the way for further research and clinical trials.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106705"},"PeriodicalIF":3.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic potential of the extracts and active compounds from the aerial parts of Dioscorea opposita (Chinese yam)

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-22 DOI: 10.1016/j.jff.2025.106707

Laibin Zhang, Xiaona Nie, Huihui Li, Shuangyan Guo, Jieli Lv

{"title":"Hypoglycemic potential of the extracts and active compounds from the aerial parts of Dioscorea opposita (Chinese yam)","authors":"Laibin Zhang, Xiaona Nie, Huihui Li, Shuangyan Guo, Jieli Lv","doi":"10.1016/j.jff.2025.106707","DOIUrl":"10.1016/j.jff.2025.106707","url":null,"abstract":"<div><div>Chinese yam (<em>Dioscorea opposita</em> rhizoma) is extensively cultivated as a homologous plant of medicine and food. Nevertheless, its aerial parts (ADO) are frequently overlooked due to a lack of clarity regarding their edible or medicinal properties. In this study, we found that the ADO extracts significantly brought down fasting blood glucose levels, increased body weight, and improved oral glucose tolerance and liver morphology in T2DM mice. Moreover, the ADO extracts markedly decreased TC, TG, LDL and MDA levels, and enhanced HDL and SOD levels in the serum of T2DM mice. Hence, ADO extracts exhibited both hypoglycemic and hypolipidemic effects. The underlying mechanism may be linked to the up-regulation of the PI3K/Akt signaling pathway and suppression of PTP1B expression. Further effective constituent studies resulted in the isolation and identification of 14 active compounds from the ADO extracts, including a novel dimeric phenanthrene, diosopposin A. All 14 compounds exhibited potent inhibitory activities against α-glucosidase or PTP1B. Among these, 11 compounds demonstrated dual inhibitory effects against both α-glucosidase and PTP1B. This study sheds light on the hypoglycemic properties of ADO, providing support for its potential development as a functional food or adjunct medicine.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106707"},"PeriodicalIF":3.8,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginkgolide B promotes fat-lowering and lifespan in Caenorhabditis elegans via DAF-2/DAF-16 signaling pathway

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-21 DOI: 10.1016/j.jff.2025.106708

Yan Zhang , Han Zhang , Wenqiao Fu , Yi Xiao

{"title":"Ginkgolide B promotes fat-lowering and lifespan in Caenorhabditis elegans via DAF-2/DAF-16 signaling pathway","authors":"Yan Zhang , Han Zhang , Wenqiao Fu , Yi Xiao","doi":"10.1016/j.jff.2025.106708","DOIUrl":"10.1016/j.jff.2025.106708","url":null,"abstract":"<div><div>Obesity and aging are significant public health issues globally, which facilitate the progression of metabolic disorders associated with chronic low-grade inflammation. These diseases are linked to high incidences of chronic conditions, influencing the quality of life and public health expenditures. Consequently, reducing obesity rates and easing the aging process constitute the foremost priorities in human health development. Ginkgolide B (GB), a monoterpene triterpene lactone extracted from ginkgo, possesses multiple attributes, including cardiovascular protection, lipid regulation, anti-apoptosis, anti-inflammation, suppression of spinal cord injury, and neuroprotection. In this investigation, we used <em>Caenorhabditis elegans</em> as a model to explore the anti-obesity and anti-aging effects of GB. We discovered that GB exerted a lipid-lowering impact and prolonged the healthy lifespan of the worms, decreased the accumulation of lipofuscin in the intestine, reduced food intake, and augmented energy expenditure. By screening the variations in fat deposition in <em>C. elegans</em> with multiple lipid metabolism pathway defect genes, we found that the <em>daf-2(e1370)</em> and <em>daf-16(mu86)</em> mutant strains, which were stained with oil red O staining after GB treatment, demonstrated a substantial reduction in fat accumulation and the disappearance of the extended lifespan phenotype. In conclusion, our results suggested that GB reduced fat accumulation and extended the healthy lifespan via the DAF-2/DAF-16 signaling pathway. These effects render GB an attractive research prospect for diseases related to obesity and aging.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106708"},"PeriodicalIF":3.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amentoflavone ameliorates DSS-induced ulcerative colitis via gut microbiota-bile acid metabolism axis modulation

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-18 DOI: 10.1016/j.jff.2025.106706

Yuting Chen , Kaipeng Li , Meiyan Zhang , Jie Liu , Man Wang , Yuhan Xiu , Qiaoyue Zhang , Ding Zhao

{"title":"Amentoflavone ameliorates DSS-induced ulcerative colitis via gut microbiota-bile acid metabolism axis modulation","authors":"Yuting Chen , Kaipeng Li , Meiyan Zhang , Jie Liu , Man Wang , Yuhan Xiu , Qiaoyue Zhang , Ding Zhao","doi":"10.1016/j.jff.2025.106706","DOIUrl":"10.1016/j.jff.2025.106706","url":null,"abstract":"<div><div>Amentoflavone (AMF) has anti-inflammatory, antibacterial, and antioxidant properties. However, the effect and underlying mechanisms of AMF on ulcerative colitis (UC) are unclear. This study aimed to examine the protective effects and regulatory mechanisms of AMF in UC in rats. AMF alleviates UC by inhibiting the spleen index, relieving colon shortening, reducing the disease activity index and reversing pathological injury of the colon tissue. Through 16 s high-throughput sequencing technology and targeted metabolomics methods, AMF was found to reconstruct intestinal microorganisms and regulate the homeostasis of bile acid metabolites. Additionally, AMF protects intestinal barrier function by activating bile acid receptors (TGR5 and FXR), and regulating tight junction proteins (ZO-1 and occludin). In conclusion, the therapeutic mechanism of AMF is mainly attributed to the activation of the gut microbiota-bile acid axis. These findings contribute to mechanistic research and drug development for AMF intervention in patients with UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106706"},"PeriodicalIF":3.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethanol extract of Lactobacillus rhamnosus AC1-fermented soymilk alleviated DSS-induced colitis via LPS-TLR4-NF-κB signaling pathway

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-14 DOI: 10.1016/j.jff.2025.106704

Haicui Wu , Weijie Fang , Yuqing Lu , Jiachi Chiou

{"title":"Ethanol extract of Lactobacillus rhamnosus AC1-fermented soymilk alleviated DSS-induced colitis via LPS-TLR4-NF-κB signaling pathway","authors":"Haicui Wu , Weijie Fang , Yuqing Lu , Jiachi Chiou","doi":"10.1016/j.jff.2025.106704","DOIUrl":"10.1016/j.jff.2025.106704","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is a chronic gastrointestinal disorder associated with a variety of factors including environmental, genetic, gut flora and immune factors. Our previous studies showed that soymilk fermented by <em>Lactobacillus rhamnosus</em> AC1 harbors anti-inflammatory and antioxidant effects. This study aimed to further investigate the beneficial effects of ethanol extract (EE) of L. <em>rhamnosus</em> AC1-fermented soymilk on dextran sulfate sodium (DSS)-induced colitis mice via LPS-TLR4-NF-κB signaling pathway and improvement of gut microbiota dysbiosis. Low dose of EE (200 mg/kg), high dose of EE (400 mg/kg), and anti-colitis drug, 5-Amino Salicylic Acid (5-ASA, 200 mg/kg), were used as the interventions in DSS-induced acute colitis. EE of L. <em>rhamnosus</em> AC1-fermented soymilk significantly alleviated body weight loss, disease activity index (DAI) scores, and histopathological damage. In addition, EE reduced apoptosis, increased proliferation, alleviated mucosa barrier damage, and down-regulated LPS-TLR4-NF-κB signaling pathway in DSS-induced colitis mice. Furthermore, the gut microbiota dysbiosis induced by DSS treatment was partially restored by EE treatments, especially in <em>Proteobacteria</em> and its lower taxa. In conclusion, the present study demonstrated that EE of L. <em>rhamnosus</em> AC1-fermented soymilk is a promising dietary intervention strategy to prevent DSS-induced colitis through down-regulation of LPS-TLR4-NF-κB signaling pathway and reverting gut microbiota dysbiosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106704"},"PeriodicalIF":3.8,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixed fruits and berries counteract the detrimental effects caused by the obesogenic cafeteria /western diet in adolescent rat model of obesity

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-14 DOI: 10.1016/j.jff.2025.106693

Rawan Al Hazaimeh, Louis Shackelford, Judith Boateng

引用次数: 0

The polysaccharides from Hemerocallis citrina Baroni alleviate cognitive impairment in high-fat diet/streptozocin-induced type 2 diabetic mice

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-02-12 DOI: 10.1016/j.jff.2025.106701

Xiaoyu Liu , Yazi Wu , Wenjing Jiang , Kexi Ma , Jinkun Du , Jingming Li

{"title":"The polysaccharides from Hemerocallis citrina Baroni alleviate cognitive impairment in high-fat diet/streptozocin-induced type 2 diabetic mice","authors":"Xiaoyu Liu , Yazi Wu , Wenjing Jiang , Kexi Ma , Jinkun Du , Jingming Li","doi":"10.1016/j.jff.2025.106701","DOIUrl":"10.1016/j.jff.2025.106701","url":null,"abstract":"<div><div>Diabetes is a global health crisis linked to cognitive decline and metabolic dysfunctions. Plant-derived polysaccharides are important components for biological functions. This study investigates the beneficial effects of individual polysaccharide components and whole polysaccharide complex extracted from dried flowers of <em>Hemerocallis citrina</em> Baroni (<em>H. citrina</em>) on type 2 diabetes mellitus (T2DM). Polysaccharides (HCPS-1 and HCPS-2) were isolated from the crude polysaccharides of <em>H. citrina</em> (HCPS), accompanied by a preliminary characterization of the structure. Polysaccharides intervention significantly exerted hypoglycemic effect and alleviated liver damage in high-fat diet (HFD)/streptozotocin-induced T2DM mice. Additionally, polysaccharides intervention significantly increased the number entering correct arm in the Y-maze test, indicating alleviated cognitive impairment. Furthermore, polysaccharides treatment improved peripheral glucose levels, and maintained energy supply to the brain through enhancing brain glucose metabolism and boosting mitochondrial respiratory chain complex activities. These results highlight the potential of <em>H. citrina</em> polysaccharide in managing T2DM and related cognitive impairment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"126 ","pages":"Article 106701"},"PeriodicalIF":3.8,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0