Journal of Functional Foods最新文献

Apple polyphenols alleviate hyperuricemia by inhibiting xanthine oxidase and promoting uric acid excretion 苹果多酚通过抑制黄嘌呤氧化酶和促进尿酸排泄来缓解高尿酸血症

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-10-04 DOI: 10.1016/j.jff.2025.107052

Ying Chen , Shuhui Hu , Yanjun Guo , Yan Wang , Lei Chen , Xin He , Yajie Yu , Andong Ji , Shengjie Pei , Kelei Li , Xiaofei Guo , Duo Li

{"title":"Apple polyphenols alleviate hyperuricemia by inhibiting xanthine oxidase and promoting uric acid excretion","authors":"Ying Chen , Shuhui Hu , Yanjun Guo , Yan Wang , Lei Chen , Xin He , Yajie Yu , Andong Ji , Shengjie Pei , Kelei Li , Xiaofei Guo , Duo Li","doi":"10.1016/j.jff.2025.107052","DOIUrl":"10.1016/j.jff.2025.107052","url":null,"abstract":"<div><div>Hyperuricemia, a metabolic disorder caused by excessive uric acid accumulation, is a major risk factor for gout and related kidney damage. Current pharmacological treatments often have side effects, emphasizing the need for safer alternatives. This study investigated the preventive and therapeutic potential of apple polyphenols (AP) in hyperuricemia management, as well as the underlying mechanisms. A cross-sectional analysis of 15,121 Chinese undergraduates revealed that apple consumption was inversely associated with hyperuricemia risk (OR = 0.86; 95 % CI: 0.73–0.99; <em>P</em> = 0.028). A hyperuricemia mouse model was established by potassium oxonate and adenine for 21 days, and AP treatment significantly reduced serum uric acid levels by inhibiting both the activity and expression of xanthine oxidase, and by downregulating renal uric acid transporters URAT1 and GLUT9. Histopathological analysis indicated that AP alleviated kidney and liver damage caused by hyperuricemia. These findings highlight the dual regulatory effect of AP on uric acid synthesis and excretion, providing new insights into its potential as a natural dietary intervention for hyperuricemia management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107052"},"PeriodicalIF":4.0,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyclocarya paliurus functional beverage: process investigation, component analysis and hypoglycemic activity research 柳青功能饮料：工艺考察、成分分析及降糖活性研究

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-10-02 DOI: 10.1016/j.jff.2025.107049

Qin Huang, Yong Yang, Tingsi Guo, Qiqi Hu, Feibing Huang, Kang Zhou, Yasi Deng, Wei Wang, Yuqing Jian

{"title":"Cyclocarya paliurus functional beverage: process investigation, component analysis and hypoglycemic activity research","authors":"Qin Huang, Yong Yang, Tingsi Guo, Qiqi Hu, Feibing Huang, Kang Zhou, Yasi Deng, Wei Wang, Yuqing Jian","doi":"10.1016/j.jff.2025.107049","DOIUrl":"10.1016/j.jff.2025.107049","url":null,"abstract":"<div><div><em>Cyclocarya paliurus</em> beverage (CPB), a traditional functional beverage widely consumed in China, has demonstrated hypoglycemic properties in folk medicine. However, its bioactive constituents and pharmacological mechanisms remain largely unexplored. This study aimed to systematically investigate the antidiabetic effects of CPB and elucidate its underlying mechanisms. The extraction process of CPB was optimized using Response Surface Methodology. Thirty-five compounds in CPB were identified by UPLC-Orbitrip-MS/MS way, and network pharmacology analysis revealed 84 potential therapeutic targets associated with T2DM. Six major bioactive compounds were quantitatively analyzed by HPLC method, and their potential targets were predicted via molecular docking. In vivo studies demonstrated that CPB treatment significantly manifested in reducing fasting blood glucose levels, improving serum lipid profiles (TC, TG, HDL-C, LDL-C), and alleviating liver, kidney and pancreatic damage in T2DM mice. These research findings collectively suggested that CPB exerts therapeutic effects against T2DM, likely through a multi-component, multi-target mechanism.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107049"},"PeriodicalIF":4.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysaccharides and flavonoids from seaweeds: A natural arsenal against drug-resistant malaria 海藻中的多糖和类黄酮：抵抗抗药性疟疾的天然武器

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-10-02 DOI: 10.1016/j.jff.2025.107050

Meivelu Moovendhan

{"title":"Polysaccharides and flavonoids from seaweeds: A natural arsenal against drug-resistant malaria","authors":"Meivelu Moovendhan","doi":"10.1016/j.jff.2025.107050","DOIUrl":"10.1016/j.jff.2025.107050","url":null,"abstract":"<div><div>Seaweed, a rich source of bioactive compounds, has garnered attention for its potential antimalarial properties, particularly through the action of polysaccharides and flavonoids. This review explores the mechanisms by which these compounds inhibit the growth of Plasmodium parasites, responsible for malaria. Sulfated polysaccharides, especially fucoidan derived from brown seaweeds, have demonstrated significant antimalarial activity by preventing the invasion of erythrocytes and suppressing parasite growth. Additionally, polysaccharides from various seaweed species, such as <em>Sargassum</em> and <em>Gracilaria</em>, have shown the capacity to enhance the immune response. Flavonoids, known for their antioxidant and anti-inflammatory properties, also exhibit antiplasmodial activity through mechanisms that may include interference with the parasite's life cycle. The review emphasizes the importance of extraction methods on the bioactivity of these compounds and discusses their potential as therapeutic agents against malaria. While promising, developing seaweed-derived antimalarial compounds faces challenges requiring further research to elucidate their mechanisms and optimize their efficacy.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107050"},"PeriodicalIF":4.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic study of phenolic acid inhibition of α-amylase: combining enzyme assays, spectroscopy, and molecular docking 酚酸抑制α-淀粉酶的机理研究：结合酶分析、光谱学和分子对接

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-10-02 DOI: 10.1016/j.jff.2025.107044

Haoyuan Shi , Tingyu Zhou , Xuemei Wang , Nan Shi , Haibin Wang , Yaqiong Wu , Yongji He , Jing Lv

{"title":"Mechanistic study of phenolic acid inhibition of α-amylase: combining enzyme assays, spectroscopy, and molecular docking","authors":"Haoyuan Shi , Tingyu Zhou , Xuemei Wang , Nan Shi , Haibin Wang , Yaqiong Wu , Yongji He , Jing Lv","doi":"10.1016/j.jff.2025.107044","DOIUrl":"10.1016/j.jff.2025.107044","url":null,"abstract":"<div><div>Type 2 diabetes (T2D) is a chronic metabolic disorder marked by persistent hyperglycemia and insulin resistance. Inhibiting α-amylase activity is a key strategy to mitigate postprandial hyperglycemia. This study investigated the inhibitory effects of structurally distinct phenolic acids—benzoic acid-type and cinnamic acid-type on α-amylase. Among them, p-hydroxybenzoic acid (PHBA) and ferulic acid (FA) showed superior inhibitory activity. PHBA (IC₅₀ = 3.08 μg/mL) demonstrated stronger inhibition than FA (76.73 μg/mL) and acarbose (16.7 μg/mL). Kinetic analysis revealed mixed-type inhibition dominated by competitive binding. Spectroscopic analyses (UV, fluorescence, CD, FT-IR) indicated that PHBA more effectively altered enzyme conformation through hydrogen bonding. Molecular docking and dynamics simulations confirmed PHBA's stronger binding affinity (−4.94 kcal/mol > −4.34 kcal/mol for FA) and greater interaction stability at the α-amylase active site. These findings provide mechanistic insight into structure–activity relationships of phenolic acids and support their potential in the development of functional foods for glycemic control.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107044"},"PeriodicalIF":4.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hesperidin blocks the gastritis-to-gastric cancer cascade: multi-pathway regulation and mechanism 橙皮苷阻断胃炎-胃癌级联：多途径调控及机制

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-30 DOI: 10.1016/j.jff.2025.107048

Siyu Deng , Sisi Tian , Qinmei Song , Yuxia Gong , Xinyue Liu , Xiaotong Chen , Jinhao Zeng , Jing Sun , Ran Li , Yu Chen

{"title":"Hesperidin blocks the gastritis-to-gastric cancer cascade: multi-pathway regulation and mechanism","authors":"Siyu Deng , Sisi Tian , Qinmei Song , Yuxia Gong , Xinyue Liu , Xiaotong Chen , Jinhao Zeng , Jing Sun , Ran Li , Yu Chen","doi":"10.1016/j.jff.2025.107048","DOIUrl":"10.1016/j.jff.2025.107048","url":null,"abstract":"<div><div>Gastric cancer is a highly malignant tumor, and Correa's cascade reveals the progression of intestinal-type gastric cancer. Developing multi-targeted agents is key to gastric cancer prevention and treatment. Hesperidin has attracted considerable attention for its anti-inflammatory, antioxidant, and anti-angiogenic effects in gastric cancer prevention and treatment. This study investigates the regulatory mechanisms of Hesperidin in gastric cancer development by targeting multiple signaling pathways. In chronic mucosal inflammation, hesperidin targets multiple signaling pathways, including Drp, ERK/Nrf2, IL-10, HIF-1α, TNF, COX, and NF-κB. Through these pathways, it controls <em>Helicobacter pylori</em> infection, inhibits mitochondrial autophagy in Cajal interstitial cells, reduces oxidative stress, and thereby alleviates inflammation and promotes ulcer healing. In gastric cancer, hesperidin induces apoptosis, inhibits cell proliferation, and suppresses angiogenesis by regulating the MAPK, PI3K/Akt, Bcl-2, and ANGPT-TIE signaling pathways. Hesperidin is well-tolerated and has been shown to improve endothelial function, reduce inflammation, and alleviate oxidative stress in clinical trials of metabolic and cardiovascular diseases. It preserves a healthy gut microbiota and is supported by well-established extraction methods, making it a promising candidate for clinical translation in preventing the progression from gastritis to gastric cancer.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107048"},"PeriodicalIF":4.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Bacillus licheniformis-based probiotic beverage modulates gut microbiota and host transcriptome to counteract obesity in a high-fat diet mouse model 基于地衣芽孢杆菌的功能性益生菌饮料调节肠道微生物群和宿主转录组，以抵消高脂肪饮食小鼠模型中的肥胖

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-30 DOI: 10.1016/j.jff.2025.107040

Hugo Ramirez-Olea, Maria Fernanda Barragan-Longoria, Rocio Alejandra Chavez-Santoscoy

{"title":"Functional Bacillus licheniformis-based probiotic beverage modulates gut microbiota and host transcriptome to counteract obesity in a high-fat diet mouse model","authors":"Hugo Ramirez-Olea, Maria Fernanda Barragan-Longoria, Rocio Alejandra Chavez-Santoscoy","doi":"10.1016/j.jff.2025.107040","DOIUrl":"10.1016/j.jff.2025.107040","url":null,"abstract":"<div><div>Obesity is characterized by gut microbiota dysbiosis, systemic inflammation, and multi-organ dysfunction. This study evaluated a <em>Bacillus licheniformis</em>-based probiotic beverage in high-fat diet (HFD)-induced obese mice. Male C57BL/6 mice received standard diet or HFD, with or without probiotic supplementation, for 21 weeks. Probiotic-treated HFD mice exhibited significantly reduced weight gain, visceral fat, hepatic steatosis, renal injury, and splenic hematopoietic stress. Glucose tolerance improved, and serum cholesterol decreased. Gut microbiota analysis revealed increased α-diversity, partial restoration of the Firmicutes/Bacteroidetes ratio, and enrichment of short-chain fatty acid-producing taxa. Liver transcriptomics showed downregulation of interferon and antigen presentation pathways, and upregulation of genes involved in tissue regeneration and lipid metabolism. These integrated physiological, microbial, and transcriptomic changes suggest systemic protection by <em>Bacillus licheniformis</em> probiotic beverage against HFD-induced damage. Our findings support its potential as a non-dairy functional intervention to modulate the gut–organ axis and restore metabolic balance in obesogenic diets.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107040"},"PeriodicalIF":4.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Total alkaloids of Zanthoxylum schinifolium Siebold & Zucc attenuate ulcerative colitis by re-profiling gut microenvironment and inhibiting TLR4/NF-κB pathway 花椒总生物碱通过重组肠道微环境和抑制TLR4/NF-κB通路减轻溃疡性结肠炎

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-29 DOI: 10.1016/j.jff.2025.107037

Yu Xiao , Jin peng Deng , Shuang Wang, Tian Feng Luo, Yun Long Deng, Ya Dai, Yi You Wu, Xiang Li

{"title":"Total alkaloids of Zanthoxylum schinifolium Siebold & Zucc attenuate ulcerative colitis by re-profiling gut microenvironment and inhibiting TLR4/NF-κB pathway","authors":"Yu Xiao , Jin peng Deng , Shuang Wang, Tian Feng Luo, Yun Long Deng, Ya Dai, Yi You Wu, Xiang Li","doi":"10.1016/j.jff.2025.107037","DOIUrl":"10.1016/j.jff.2025.107037","url":null,"abstract":"<div><div>Ulcerative colitis (UC), as a chronic and recurrent inflammatory bowel illness, has become more commonplace worldwide recently. Green Sichuan Pepper (<em>Zanthoxylum schinifolium</em> Siebold & Zucc, ZS) is a spice and traditional Chinese medicine used millennia in China, total alkaloids of which (TAZS) are important and representative bioactive compounds with multiple pharmacological activities. While, the effects of TAZS on UC have been still unknown. In this study, the effects and the underlying mechanisms of TAZS on UC were investigated. Results showed that TAZS (80 mg/kg·d<sup>−1</sup>, i.g.) significantly relieved colitis symptoms and intestinal barrier impairment, inhibited colonic inflammation, and maintained intestinal microenvironment homeostasis. The mechanism of TAZS on UC was through suppressing the abnormal activation of the TLR4/NF-κB pathway, by itself and modulation of gut microenvironment (including intestinal flora and gut microbial metabolites). The present study highlighted the potential of TAZS as a dietary agent for the prevention or treatment of UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107037"},"PeriodicalIF":4.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seaweed-derived polysaccharides: Multifunctional biomaterials for gut health and wound healing applications 海藻衍生多糖：用于肠道健康和伤口愈合的多功能生物材料

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-29 DOI: 10.1016/j.jff.2025.107045

Santhosh Sigamani , Sathish Kumar Venkatachalam , Prathapavarma Digala , Murali Santhoshkumar , Senthilkumar Dharmaraj , Nallusamy Duraisamy , Gholamreza Abdi

{"title":"Seaweed-derived polysaccharides: Multifunctional biomaterials for gut health and wound healing applications","authors":"Santhosh Sigamani , Sathish Kumar Venkatachalam , Prathapavarma Digala , Murali Santhoshkumar , Senthilkumar Dharmaraj , Nallusamy Duraisamy , Gholamreza Abdi","doi":"10.1016/j.jff.2025.107045","DOIUrl":"10.1016/j.jff.2025.107045","url":null,"abstract":"<div><div>Seaweed-derived polysaccharides including carrageenan, alginate, ulvan, and fucoidan have garnered increasing attention for their multifunctional bioactivities and biocompatibility, positioning them as promising agents in tissue engineering, regenerative medicine, and gastrointestinal therapy. These marine biopolymers exhibit broad spectrum of therapeutic properties such as antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory effects. In wound repair and tissue regeneration, they support cell proliferation, enhance mechanical stability, and enable controlled delivery of bioactive compounds. In the context of inflammatory bowel disease (IBD), polysaccharides from green (Ulva), red (<em>Porphyra</em>, <em>Gracilaria</em>), and brown (<em>Laminaria</em>, <em>Undaria</em>) algae have demonstrated significant benefits in experimental models by modulating immune signaling pathways, restoring gut barrier integrity, and promoting beneficial microbiota and metabolite profiles. Advanced applications including fucoidan-based bioinks for 3D bioprinting and polysaccharide-derived nanocarriers further highlight their potential in drug delivery and therapeutic modulation. Overall, seaweed polysaccharides represent a promising class of natural biomaterials with wide-ranging biomedical applications, warranting continued research and clinical translation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107045"},"PeriodicalIF":4.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of Chlorella pyrenoidosa peptides 蛋白核小球藻肽的神经保护作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-29 DOI: 10.1016/j.jff.2025.107038

Kaiyin Deng , Shaojun Hu , Shuting Feng , Changtai You , Dingding Wang , Houlei Jia , Lili Hu

{"title":"Neuroprotective effects of Chlorella pyrenoidosa peptides","authors":"Kaiyin Deng , Shaojun Hu , Shuting Feng , Changtai You , Dingding Wang , Houlei Jia , Lili Hu","doi":"10.1016/j.jff.2025.107038","DOIUrl":"10.1016/j.jff.2025.107038","url":null,"abstract":"<div><div>Neurodegenerative diseases are chronic neurological disorders characterized by the progressive loss of neurons, severely affecting patients' cognition, memory, and motor functions. However, existing therapies struggle to reverse the disease course. This study utilized BV2 cells and <em>Caenorhabditis elegans</em> models to induce neuronal damage through chemical agents, exploring the neuroprotective effects of <em>Chlorella pyrenoidosa</em> peptides (CPP). CPP reduced ROS levels, increased the activity of GSH,SOD and CAT in cells and nematodes, as well as reduced NO, TNF-α, IL-6 content in cells. Additionally, it elevated the mitochondrial membrane potential of cells and reduced cell apoptosis, and enhanced cellular lysosomal activity. Furthermore, CPP reduced Aβ deposition and mitigated the neurotoxicity induced by enhancing memory and chemotaxis, decreasing AchE levels and sensitivity to 5-HT. CPP upregulated the expression of genes such as ced-9, sir-2.1, and daf-16 while downregulating ced-4, ced-3 expressions, suggesting that their neuroprotection might involve regulating immune-related, stress-resistant, and anti-apoptotic genes.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107038"},"PeriodicalIF":4.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145218126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor, anti-inflammatory, and antioxidant activities of anthocyanins from food and isolated sources: Methodological insights and interactions with the intestinal microbiota 来自食物和分离来源的花青素的抗肿瘤、抗炎和抗氧化活性：方法见解和与肠道微生物群的相互作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-27 DOI: 10.1016/j.jff.2025.107026

Érika de Fátima dos Santos , Yasmin Neves Vieira Sabino , Elisa Nassif Montenegro , Cinthia Alvim Faria , Thaís Costa de Almeida , Jacy Gameiro , Sheila Cristina Potente Dutra Luquetti , Alessandra Barbosa Ferreira Machado , Juarez Campolina Machado

{"title":"Antitumor, anti-inflammatory, and antioxidant activities of anthocyanins from food and isolated sources: Methodological insights and interactions with the intestinal microbiota","authors":"Érika de Fátima dos Santos , Yasmin Neves Vieira Sabino , Elisa Nassif Montenegro , Cinthia Alvim Faria , Thaís Costa de Almeida , Jacy Gameiro , Sheila Cristina Potente Dutra Luquetti , Alessandra Barbosa Ferreira Machado , Juarez Campolina Machado","doi":"10.1016/j.jff.2025.107026","DOIUrl":"10.1016/j.jff.2025.107026","url":null,"abstract":"<div><div>Anthocyanins are secondary metabolites found in plants, commonly present in fruits such as strawberries, grapes, and blueberries. They act as antioxidants, protecting plant cells from oxidative damage, and are known for their potential role in chronic disease prevention. In studies, anthocyanins have been investigated both in food matrices and in isolated forms. They neutralize free radicals, which can damage cells, and reduce inflammation by downregulating pro-inflammatory cytokines involved in chronic diseases. Additionally, they have shown potential in modulating tumor cell proliferation, making them valuable for human health. This review explores the antioxidant, anti-inflammatory, and antitumor activities of anthocyanins, highlighting the methods used to assess these properties. Moreover, it discusses their interaction with the gut microbiota, which enhances anthocyanin biological effect through the production of short-chain fatty acids and phenolic metabolites derived from microbial metabolism. The review also addresses the challenges and future perspectives for the industrial-scale application of anthocyanins.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"134 ","pages":"Article 107026"},"PeriodicalIF":4.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0