Journal of Functional Foods最新文献

The role of SREBP-1c signaling pathway in osteoblast pyroptosis and the protective effect of D-pinitol SREBP-1c信号通路在成骨细胞焦亡中的作用及d -蒎醇的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-02 DOI: 10.1016/j.jff.2025.106846

Yajuan Wang , Fang Li , Xue Wang , Baoying Li , Wenqian Zhao , Chaochao Dai , Jie Wang , Haiqing Gao , Mei Cheng

{"title":"The role of SREBP-1c signaling pathway in osteoblast pyroptosis and the protective effect of D-pinitol","authors":"Yajuan Wang , Fang Li , Xue Wang , Baoying Li , Wenqian Zhao , Chaochao Dai , Jie Wang , Haiqing Gao , Mei Cheng","doi":"10.1016/j.jff.2025.106846","DOIUrl":"10.1016/j.jff.2025.106846","url":null,"abstract":"<div><div>Preclinical animal studies and human trials have indicated that D-pinitol may have multiple beneficial properties, such as regulating lipid metabolism and anti-osteoporosis. The purpose of this research was to use in vivo and in vitro methods to explore lipid-induced pyroptosis in osteogenic differentiation and osteoporosis development, while also examining DP's regulatory role in preventing osteoblast pyroptosis. Results demonstrated that daily oral administration of D-pinitol (DP) at a clinically relevant dose significantly ameliorated bone microarchitecture deterioration in apolipoprotein A1-deficient (ApoA1<sup>−/−</sup>) mice. DP increased Runx2 and OST expressions, and enhanced the bone-mineralized nodules production in ox-LDL-treated MC3T3-E1 cells. DP also lowered pyroptosis-related indicators such as NLRP3, Caspase-1, GSDMD, GSDMD N-terminal (GSDMD-NT), Cleaved caspase-1, and IL-1β. Mechanistically, we found that DP inhibited NLRP3-mediated pyroptosis by downregulating SREBP-1c and altering p53 and Galectin-1 signaling. Our findings indicated that SREBP-1c is involved in lipid metabolism disorder-induced activation of the NLRP3 and ultimately results in osteogenic pyroptosis. DP could inhibit the SREBP-1c pathway to protect osteoblasts, thereby ameliorating osteoporosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106846"},"PeriodicalIF":3.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats” [Journal of Functional Foods 127 (2025) 106772] “Sacha inchi meal蛋白水解物减轻HepG2和3t3 - l1细胞的脂质积累和氧化应激，并协同增强l -名称诱导的高血压大鼠卡托普利的降压作用”的更正[Journal of Functional Foods 127 (2025) 106772]

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-01 DOI: 10.1016/j.jff.2025.106805

Pakaporn Sa-nguanpong , Paweena Wetprasit , Anjaree Inchan , Chartchai Chaichana , Worasak Kaewkong , Natthawut Charoenphon , Kannika Adthapanyawanich , Krit Tantanarat , Worasit Tochampa , Khanitta Ruttarattanamongkol , Tippaporn Bualeong

引用次数: 0

Efficacy and molecular mechanisms of natural polysaccharides in the treatment of kidney diseases 天然多糖治疗肾脏疾病的疗效及分子机制研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-01 DOI: 10.1016/j.jff.2025.106859

Fang Cheng , Zheng Cui , Qiang Li , Kaiping Wang , Yu Zhang

引用次数: 0

Clinacanthus nutans restores the intestinal barrier in UC via regulatings oxidative stress to suppress the occurrence of ferroptosis 狼棘通过调节氧化应激来抑制铁下垂的发生，从而恢复UC的肠道屏障

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-30 DOI: 10.1016/j.jff.2025.106863

Ximin Wang , Qing Luo , Jing Yang , Weijie Peng , Gengting Dong , Xianjing Hu , Weibo Dai

引用次数: 0

Serum pharmacochemistry profiling combined with molecular docking analysis to reveal the pharmacodynamic material basis of Lonicerae japonicae flos against acute lung injury 血清药物化学分析结合分子对接分析揭示金银花抗急性肺损伤的药效学物质基础

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-30 DOI: 10.1016/j.jff.2025.106858

Ziyu Zhang , Xiaoying Yang , Chang Liu , Xianfa Zeng , Zhigang Yin , Yulong Liu , Jiangli Luo , Ying Zhou

{"title":"Serum pharmacochemistry profiling combined with molecular docking analysis to reveal the pharmacodynamic material basis of Lonicerae japonicae flos against acute lung injury","authors":"Ziyu Zhang , Xiaoying Yang , Chang Liu , Xianfa Zeng , Zhigang Yin , Yulong Liu , Jiangli Luo , Ying Zhou","doi":"10.1016/j.jff.2025.106858","DOIUrl":"10.1016/j.jff.2025.106858","url":null,"abstract":"<div><div><em>Lonicerae japonicae flos</em> (LJF), a medicine and food homology substance, regulates inflammatory responses. Our preliminary study demonstrated that LJF can intervene in acute lung injury (ALI) through the IL-17 signaling pathway via RNA-seq, yet the material basis remains unclear. Thus, the aim is to investigate the potential targets and pharmacodynamic material basis of LJF against ALI through serum pharmacochemistry and molecular docking. Utilizing ELISA and HE staining, the expression of IL-17C, IL-17F, CXCL2, and CXCL6 was notably downregulated in the LJF group, leading to an improvement in alveolar histological structure damage and a reduction in lung inflammation. Consequently, compared with the ALI group, western blotting results revealed that the expression levels of IL-17F proteins were significantly decreased in the LJF group, confirming IL-17F as the primary target. Subsequently, in accordance with the serum pharmacochemistry theory of traditional Chinese medicine, a total of 30 blood-absorbed ingredients were screened in the LJF. Molecular docking demonstrated that isochlorogenic acid B exhibited strong binding affinity with the IL-17F targets. The results of in vitro experiments indicated that isochlorogenic acid B suppressed the expression of the downstream signaling pathways MAPK and NF-κB by targeting IL-17F, subsequently reducing the levels of inflammatory mediators to treat ALI. In light of physiological and pathological insights, this study has pinpointed the characteristic constituents and blood-absorbed ingredients of LJF. It has also identified the key active components and potential targets associated with its anti-ALI effects, thereby elucidating the pharmacodynamic basis of LJF in the prevention of acute lung injury.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106858"},"PeriodicalIF":3.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of pasteurized Akkermansia muciniphila on metabolic and behavioral dysregulation in a zebrafish model of type 2 diabetes mellitus comorbid with depression 巴氏杀菌嗜黏液阿克曼氏菌对2型糖尿病伴抑郁斑马鱼代谢和行为失调的治疗作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-29 DOI: 10.1016/j.jff.2025.106848

Linkai Qu , Jiaxuan He , Ting Xu , Yiting Jiang , Chunyi Xu , Lei Wang , Cheng Luo , Qinsi Yang , Rongbing Chen , Yanyan Xie , Nian Wang , Fan Liu , Da Sun , Dongjuan He

{"title":"Therapeutic effects of pasteurized Akkermansia muciniphila on metabolic and behavioral dysregulation in a zebrafish model of type 2 diabetes mellitus comorbid with depression","authors":"Linkai Qu , Jiaxuan He , Ting Xu , Yiting Jiang , Chunyi Xu , Lei Wang , Cheng Luo , Qinsi Yang , Rongbing Chen , Yanyan Xie , Nian Wang , Fan Liu , Da Sun , Dongjuan He","doi":"10.1016/j.jff.2025.106848","DOIUrl":"10.1016/j.jff.2025.106848","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) and depression (DEP) frequently co-occur, with growing evidence implicating the gut microbiota in both conditions. In this study, we investigated the therapeutic potential of pasteurized <em>Akkermansia muciniphila</em> (AKK) in a zebrafish model of T2DM comorbid with DEP, established through a high-sugar, high-fat diet and reserpine exposure. Zebrafish treated with pasteurized AKK exhibited significant improvements in metabolic parameters, including reduced fasting blood glucose, body mass index, and improved lipid profiles. AKK also restored gut microbial diversity, increasing beneficial bacteria such as <em>Cetobacterium</em> and reducing harmful bacteria like <em>Aerococcus</em>. Importantly, AKK treatment alleviated anxiety-like behaviors, improved social interactions, and enhanced monoamine neurotransmitter levels (5-HT and NE), likely through modulation of the BDNF-TrkB signaling pathway and reduction of pro-inflammatory cytokines (IL-6, TNF-α). These findings suggest that pasteurized AKK offers a novel microbiota-based intervention for managing the metabolic and neuropsychiatric dysfunctions associated with T2DM and DEP comorbidity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106848"},"PeriodicalIF":3.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food-grade Lactococcus lactis expressing LEK peptide ameliorates hypertension and hyperlipidemia via ACE inhibition and lipid metabolism regulation 表达LEK肽的食品级乳酸乳球菌通过抑制ACE和调节脂质代谢来改善高血压和高脂血症

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-29 DOI: 10.1016/j.jff.2025.106830

Fei Gao , Yan Pan , Han Tao , Xiaolong Yuan , Suwan Li , Junlong Gao , Mohamed A. Farag , Kexin Liu , Lili Song

{"title":"Food-grade Lactococcus lactis expressing LEK peptide ameliorates hypertension and hyperlipidemia via ACE inhibition and lipid metabolism regulation","authors":"Fei Gao , Yan Pan , Han Tao , Xiaolong Yuan , Suwan Li , Junlong Gao , Mohamed A. Farag , Kexin Liu , Lili Song","doi":"10.1016/j.jff.2025.106830","DOIUrl":"10.1016/j.jff.2025.106830","url":null,"abstract":"<div><div><em>Torreya grandis-</em>derived peptide LEK is recognized for its potential to improve hypertension. However, its exact function and mechanism of action remain unknown. In addition, its widespread application is hindered by the high production costs and susceptibility to gastrointestinal digestion. To overcome these limitations, we developed an innovative approach using food-grade <em>Lactococcus lactis</em> as a delivery system to produce LEK peptide. The current study demonstrated that the LEK-deriving <em>L. lactis</em> significantly regulated hypertension in mice via ACE-related pathway. To our surprise, LEK-deriving <em>L</em>. <em>lactis</em> also significantly reduced serum total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in high-fat diet mice, and improved hepatic lipid levels. Further investigation into the molecular mechanisms revealed that the engineered <em>L</em>. <em>lactis</em> could modulate the expression of key genes such as <em>Pparg</em>, <em>Fasn</em>, <em>Cd36</em>, and <em>Hmgcr</em>. This study offers a novel solution for producing LEK peptide and their applications in the treatment of hyperlipidemia.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106830"},"PeriodicalIF":3.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prickly pear (Rosa roxburghii Tratt.) extract alleviates ethanol-induced oxidative stress in vivo and in vitro via Fanconi Anemia pathway 刺梨提取物可通过范可尼贫血途径缓解乙醇诱导的体内外氧化应激

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-29 DOI: 10.1016/j.jff.2025.106860

Zhaowei Chen , Jingyi Xu , Yixiao Wu , Lei Zhou , Jie Kong , Mengning Lan , Bin Wang , Huajun Zheng

{"title":"Prickly pear (Rosa roxburghii Tratt.) extract alleviates ethanol-induced oxidative stress in vivo and in vitro via Fanconi Anemia pathway","authors":"Zhaowei Chen , Jingyi Xu , Yixiao Wu , Lei Zhou , Jie Kong , Mengning Lan , Bin Wang , Huajun Zheng","doi":"10.1016/j.jff.2025.106860","DOIUrl":"10.1016/j.jff.2025.106860","url":null,"abstract":"<div><div>Prickly pear extract (PPE) exhibits diverse effects, including antioxidative, hypoglycemic, and antiobesity properties. While its role in alcoholic liver disease (ALD) prevention remains understudied, this research unveils PPE's chemical composition (total protein, sugar, phenols, flavonoids, and polyphenols). Employing an ALD animal model, we identified 12 PPE metabolites that directly entered the liver, mitigating alcohol-induced oxidative damage by reducing ALT, AST, and MDA levels, elevating SOD and GSH levels, and enhancing ADH and ALDH enzymatic activity. Examining ethanol-induced HepG2 cells, PPE activated the Fanconi anemia (FA) pathway, upregulating proteins (ub-FANCD2, ub-FANCI, FANCA) involved in antioxidant gene expression and FA complex proteins (ub-FANCM, MHF1, FAAP24) promoting DNA repair. These findings highlight PPE's ability to combat oxidative stress and DNA damage through FA pathway activation, affirming its hepatoprotective potential as a natural product.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106860"},"PeriodicalIF":3.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concord grape (Vitis labrusca ‘Concord’) pomace extract impacts dextran sulfate sodium-induced inflammation in ovo (Gallus gallus) 康科德葡萄（Vitis labrusca ' Concord '）果渣提取物对葡聚糖硫酸盐钠诱导蛋鸡炎症的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-28 DOI: 10.1016/j.jff.2025.106840

Melissa Y. Huang, Eliot M. Dugan, Elad Tako

引用次数: 0

Lycopene prevents the intestinal toxicity caused by cyclophosphamide via NCOA4-induced ferroptosis pathway 番茄红素通过ncoa4诱导的铁下垂途径阻止环磷酰胺引起的肠道毒性

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-28 DOI: 10.1016/j.jff.2025.106862

Xiaoran Liu, Yun Dai, Yupei Yao, Jianling Chen, Lei Ma, Mingyuan Yin, Lirong Han

{"title":"Lycopene prevents the intestinal toxicity caused by cyclophosphamide via NCOA4-induced ferroptosis pathway","authors":"Xiaoran Liu, Yun Dai, Yupei Yao, Jianling Chen, Lei Ma, Mingyuan Yin, Lirong Han","doi":"10.1016/j.jff.2025.106862","DOIUrl":"10.1016/j.jff.2025.106862","url":null,"abstract":"<div><div>This study evaluated the novel mechanism of lycopene (LP) preventing cyclophosphamide (CYC)-induced intestinal toxicity. The results of <em>in vitro</em> showed that compared with the control, phosphoramide mustard (PM) treatment significantly reduced Caco-2 cell viability and SOD activity, increased MDA content, promoted Fe<sup>2+</sup> accumulation, and upregulated NCOA4. Compared with the PM treatment, Fer-1 + PM or siRNA-NCOA4 + PM significantly increased GSH content in Caco-2 cells, decreased ROS content, inhibited autophagy, downregulated NCOA4 and COX2, and upregulated GPX4 and FTH1. More importantly, PM + 8 μM LP significantly reversed these effects of PM. The results of <em>in vivo</em> showed that compared with the control, the autophagy in the intestinal tissues of CYC mice was significantly increased, and the NCOA4 and COX2 proteins were up-regulated, while the GPX4 and FTH1 were down-regulated. Compared with the CYC group, 10 mg/kg LP + CYC significantly reversed the above phenomenon. In conclusion, LP inhibited CYC-induced ferroptosis by blocking the NCOA4-mediated ferritinophagy signaling pathway.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106862"},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0