Journal of Functional Foods最新文献

Lignan-enriched nutmeg extract changes gut microbiota associated with aging in C57BL/6 mice 富含木脂素的肉豆蔻提取物改变与C57BL/6小鼠衰老相关的肠道微生物群

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-19 DOI: 10.1016/j.jff.2025.106966

Ji-Seon Ahn , Jae Uk Kim , Je-Ho Lee , Gyung-Tae Ban , Yoosik Yoon , Hwa-Seung Yoo , Jong-Soon Choi , Hea-Jong Chung

{"title":"Lignan-enriched nutmeg extract changes gut microbiota associated with aging in C57BL/6 mice","authors":"Ji-Seon Ahn , Jae Uk Kim , Je-Ho Lee , Gyung-Tae Ban , Yoosik Yoon , Hwa-Seung Yoo , Jong-Soon Choi , Hea-Jong Chung","doi":"10.1016/j.jff.2025.106966","DOIUrl":"10.1016/j.jff.2025.106966","url":null,"abstract":"<div><div>As the aging population grows, increasing interest in promoting healthy aging through dietary interventions is growing. Gut microbiota play a key role in age-related physiological decline and longevity. We investigated whether lignan-enriched nutmeg extract (LNX) could modulate the gut microbiota of aged mice. C57BL/6 mice (27 months old) were orally administered LNX for 5 weeks and compared to young (3 months) and aged controls. LNX significantly reduced body weight without affecting food intake. 16S rRNA sequencing showed that age-related microbial shifts, including decreased <em>Firmicutes</em> and increased <em>Bacteroidota</em>, were partially reversed by LNX. While microbial diversity was unchanged, LNX increased <em>Bifidobacterium</em>, <em>Blautia</em>, and <em>Acetatifactor muris</em>, a taxon previously associated with healthy aging, and reduced <em>Turicibacter sanguinis</em>, linked to normal aging. These findings suggest that LNX modulates specific microbial taxa without broadly restoring a youthful microbiota composition.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106966"},"PeriodicalIF":3.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the biochemical and functional properties of water kefir: Comparative effects of different water sources with emphasis on deep ocean water 提高水开菲尔的生化和功能特性：不同水源的比较效果，重点是深海水

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-18 DOI: 10.1016/j.jff.2025.106965

Ji Yeon Lee , Hayeong Kim , Tae-hui Yang , Sejin Oh , Ghahyun Jeffrey Kim , Soyoung Park , Sichul Lee , Il-Kyoon Mok , Dong Hyun Kang , Doman Kim

{"title":"Enhancing the biochemical and functional properties of water kefir: Comparative effects of different water sources with emphasis on deep ocean water","authors":"Ji Yeon Lee , Hayeong Kim , Tae-hui Yang , Sejin Oh , Ghahyun Jeffrey Kim , Soyoung Park , Sichul Lee , Il-Kyoon Mok , Dong Hyun Kang , Doman Kim","doi":"10.1016/j.jff.2025.106965","DOIUrl":"10.1016/j.jff.2025.106965","url":null,"abstract":"<div><div>Water kefir has gained popularity as a traditional fermented beverage associated with various health benefits. In this study, water kefir was fermented with deionized water (DW), deep-ocean water (DOW) and natural mineral water (NMW) to compare physicochemical and health-promoting traits. DOW kefir (DOWK) reached pH 3.03 and titratable acidity 9.54 g/L, versus 3.37/1.52 g/L (DWK) and 3.69/4.46 g/L (NMWK). HPLC showed DWK contained only acetic acid (0.10 g/L), while DOWK and NMWK accumulated gluconic acid (0.26–0.31 g/L), lactic acid (0.13–0.19 g/L), and higher acetic acid (1.60–4.24 g/L). All grains bore α-1,6 glucosyl linkages. DOWK displayed the greatest antioxidant capacity and α-glucosidase inhibition, 1.13–3.51-fold above DWK/NMWK, and the strongest antibacterial action against <em>Salmonella</em>, <em>E. coli</em> and <em>S. aureus</em> (MIC 25–50 % <em>v</em>/v). DWK showed minimal inhibition. The mineral profile of DOW thus stimulates microbial metabolism and yields water kefir with superior health-related properties, supporting its use in value-added functional beverages.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106965"},"PeriodicalIF":3.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the physicochemical and functional characteristics of biologically active food-derived peptides 生物活性食物来源多肽的物理化学和功能特性研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-17 DOI: 10.1016/j.jff.2025.106964

Min He , Chunhong Liu , Xiaohai Zhang , Xueqiang Chen , Opeyemi Joshua Olatunji , Itthanan Suttikhana , Thanh-Do Le , Tolulope Joshua Ashaolu

{"title":"Insights into the physicochemical and functional characteristics of biologically active food-derived peptides","authors":"Min He , Chunhong Liu , Xiaohai Zhang , Xueqiang Chen , Opeyemi Joshua Olatunji , Itthanan Suttikhana , Thanh-Do Le , Tolulope Joshua Ashaolu","doi":"10.1016/j.jff.2025.106964","DOIUrl":"10.1016/j.jff.2025.106964","url":null,"abstract":"<div><div>Food-derived peptides (FDPs) have garnered significant interest due to their diverse physicochemical properties and functional attributes, contributing to their applications in health, nutrition, and the food industry. These peptides, generated through enzymatic hydrolysis or fermentation, exhibit a range of molecular structures and physicochemical characteristics, including solubility, stability, and amphiphilicity, which influence their bioavailability and efficacy. Functionally, they possess various bioactivities, such as antioxidant, antihypertensive, antimicrobial, and immunomodulatory effects, making them promising candidates for functional foods and nutraceuticals. This review comprehensively examines the physicochemical characteristics, bioactivity, and functional roles of FDPs. Key physicochemical properties, such as molecular weight, hydrophobicity, charge distribution, and stability are discussed in relation to their bioactivity and functionality. The valuable insights into the multifunctional roles of FDPs emphasize their potential as bioactive ingredients in functional foods, nutraceuticals, and therapeutic applications. Understanding these characteristics can enhance peptide utilization in improving food quality, safety, and human health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106964"},"PeriodicalIF":3.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemp seed oil ameliorates ulcerative colitis in connection with tryptophan metabolism driven by gut microbiota 大麻籽油改善溃疡性结肠炎与肠道菌群驱动色氨酸代谢

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-17 DOI: 10.1016/j.jff.2025.106962

Jing Yang, Yiyun Guan, Junjie Zhou, Yujie Zhang, Lixi Li, Hailong Lu, Zhongjie Zou, Mengjuan Gong

{"title":"Hemp seed oil ameliorates ulcerative colitis in connection with tryptophan metabolism driven by gut microbiota","authors":"Jing Yang, Yiyun Guan, Junjie Zhou, Yujie Zhang, Lixi Li, Hailong Lu, Zhongjie Zou, Mengjuan Gong","doi":"10.1016/j.jff.2025.106962","DOIUrl":"10.1016/j.jff.2025.106962","url":null,"abstract":"<div><div>Ulcerative colitis (UC), a chronic inflammatory bowel disease, currently lacks effective therapeutic strategies. This study investigated the protective effects of hemp seed oil (HSO), a dietary supplement derived from hemp seeds (<em>Cannabis sativa</em> L.) possessing anti-inflammatory properties, against UC. Using 16S rRNA sequencing, fecal microbiota transplantation (FMT), and targeted tryptophan (Trp) metabolomics, we explored the mechanisms underlying HSO's effects in dextran sulfate sodium (DSS)-induced UC mice. Results showed HSO significantly alleviated UC symptoms, restored gut microbiota dysbiosis, and increased short-chain fatty acids (SCFAs) production. FMT results revealed HSO selectively promoted <em>Muribaculum</em> and <em>Roseburia</em> growth, enhancing Trp metabolites such as indole-3-acetic acid (IAA) and 3-indolealdehyde (3-IAld). Additionally, HSO upregulated aryl hydrocarbon receptor (AhR) expression and interleukin (IL)-22 production, promoting tight junction protein expression and intestinal barrier repair. These findings suggested HSO as a promising dietary intervention for UC management by targeting gut microbiota-mediated Trp metabolism and the AhR/IL-22 axis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106962"},"PeriodicalIF":3.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theaflavins, theaflavin-3,3′-digallate, and its nanoparticles attenuate chronic alcohol-induced gastric injury and hepatic fibrosis by activating the AMPK/mTOR/Beclin1/LC3 autophagy pathway and modulating intestinal microbiota in ICR mice 茶黄素、茶黄素-3,3 ' -二二酸酯及其纳米颗粒通过激活AMPK/mTOR/Beclin1/LC3自噬途径和调节肠道微生物群，减轻慢性酒精诱导的胃损伤和肝纤维化

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-16 DOI: 10.1016/j.jff.2025.106957

Ying Wang , Dan Zhang , Jiahong Chen , Ziyu Kong , Ling Wu , Zenghui Liu , Qingqing Zhai , Yan Xu

{"title":"Theaflavins, theaflavin-3,3′-digallate, and its nanoparticles attenuate chronic alcohol-induced gastric injury and hepatic fibrosis by activating the AMPK/mTOR/Beclin1/LC3 autophagy pathway and modulating intestinal microbiota in ICR mice","authors":"Ying Wang , Dan Zhang , Jiahong Chen , Ziyu Kong , Ling Wu , Zenghui Liu , Qingqing Zhai , Yan Xu","doi":"10.1016/j.jff.2025.106957","DOIUrl":"10.1016/j.jff.2025.106957","url":null,"abstract":"<div><div>This study investigated the protective effects of theaflavins (TFs), theaflavin-3,3′-digallate (TFDG), and TFDG nanoparticles (TFDGN) against chronic alcohol-induced gastric and hepatic injuries in mice. Using an eight-week alcohol administration model, this study demonstrated that TFs, TFDG, and TFDGN significantly reduced mortality, liver index, and serum biomarkers of hepatic injury, while increasing glutathione levels. Histopathology confirmed the attenuation of hepatic inflammation, fibrosis, and gastric mucosal damage. Mechanistically, these compounds activated gastric cell autophagy via the downregulation of p-mTOR and the upregulation of p-AMPK, Beclin1, and LC3-II. Additionally, they modulated gut microbiota by enriching probiotics (<em>Lactobacillus</em>, <em>Akkermansia</em> and <em>Oscillibacter</em>) while reducing pathogens (<em>Allobaculum</em>, <em>Faecalibaculum</em> and <em>Enterococcus</em>). Among the tested compounds, TFDGN exhibited superior efficacy. These findings demonstrate that TFs, TFDG, and TFDGN provide protection against alcohol-induced damage by regulating autophagy, reducing fibrosis, and restoring gut microbiota balance, highlighting their potential as natural therapeutics for alcohol-related gastric and hepatic disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106957"},"PeriodicalIF":3.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the sweet culprit: Excessive fructose intake leading to kidney injury through hypoxanthine accumulation 揭开甜蜜的罪魁祸首：过量的果糖摄入通过次黄嘌呤积累导致肾脏损伤

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-16 DOI: 10.1016/j.jff.2025.106959

Gaoxiang Ai , Wenwen Tan , Ziwei Huang , Lieqing Xu , Qiuxia Yu , Xiaoyan Wu , Jianhui Xie , Ziren Su , Jiannan Chen , Xiaolian Chen , Yaoxing Dou

{"title":"Unveiling the sweet culprit: Excessive fructose intake leading to kidney injury through hypoxanthine accumulation","authors":"Gaoxiang Ai , Wenwen Tan , Ziwei Huang , Lieqing Xu , Qiuxia Yu , Xiaoyan Wu , Jianhui Xie , Ziren Su , Jiannan Chen , Xiaolian Chen , Yaoxing Dou","doi":"10.1016/j.jff.2025.106959","DOIUrl":"10.1016/j.jff.2025.106959","url":null,"abstract":"<div><div>Fructose, a frequent-using sweeter, has been widely used in the food and beverage industry. Notably, prolonged consumption of fructose-rich diets has been recognized as a culprit causing kidney injury. However, it remains elusively obscure whether excessive fructose intake resulted in hypoxanthine (HX) accumulation and further induced kidney injury. Therefore, the present work made a pioneering endeavor to unravel the potential material basis of fructose-induced kidney injury and further probed its underlying pathogenic mechanism. Results indicated that long-term high-fructose intake contributed to HX accumulation, which subsequently triggered inflammation and oxidative damage. Moreover, further mechanistic investigations suggested that accumulated HX inhibited nuclear factor-erythroid-2-related factor 2 (Nrf2) nuclear translocation and consequently down-regulated expressions of downstream antioxidant proteins. Additionally, it effectively promoted NOD-like receptor 3 (NLRP3) inflammasome activation. Altogether, these findings suggested that excessive fructose consumption facilitated HX accumulation, which further aggravated kidney injury, at least in part, via modulating the Keap1-Nrf2/NLRP3 signaling axis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106959"},"PeriodicalIF":3.8,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal protective effects and mechanisms of finger citron essential oil in dextran sulfate sodium-induced ulcerative colitis mice model 手指香橼精油对硫酸葡聚糖钠致溃疡性结肠炎小鼠模型的肠道保护作用及机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-14 DOI: 10.1016/j.jff.2025.106961

Junyun Luo , Niang Tang , Chenghai Peng , Qun Wang , Shuxi Chen , Aimei Zhou

引用次数: 0

Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals 顺式异丙酸通过调节哺乳动物的食物摄入和脂质代谢而具有抗肥胖作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-14 DOI: 10.1016/j.jff.2025.106958

Yuchan Wen , Ruihan Zhang , Jiatong Xie, Ailin Wan, Shuozheng Mei, Jiwei Xie, Shuyi Lei, Qingyou Xia, Genhong Wang

{"title":"Cis-vaccenic acid exhibits an anti-obesity effect by regulating food intake and lipid metabolism in mammals","authors":"Yuchan Wen , Ruihan Zhang , Jiatong Xie, Ailin Wan, Shuozheng Mei, Jiwei Xie, Shuyi Lei, Qingyou Xia, Genhong Wang","doi":"10.1016/j.jff.2025.106958","DOIUrl":"10.1016/j.jff.2025.106958","url":null,"abstract":"<div><div>Cis-vaccenic acid has been shown to regulate food intake in <em>Bombyx mori</em>, but its potential role in mammals remains unclear. In this study, mice were fed either standard or high-fat diets supplemented with cis-vaccenic acid to evaluate its effects on satiety regulation and related physiological/biochemical parameters. The results demonstrated that dietary cis-vaccenic acid enhanced satiation in mice through significant upregulation of cholecystokinin and peptide tyrosine tyrosine expression, ultimately leading to a 16.1 % reduction in weight gain and 34.1 % decrease in food intake. qRT-PCR analysis revealed that cis-vaccenic acid administration downregulated hepatic lipogenesis-related genes (ACC, SREBP-1a, FAS, and SCD-1/SCD-2) while upregulating lipid catabolism-associated genes (PPARα and CPT-1). Histological evaluations showed that cis-vaccenic acid supplementation effectively mitigated HFD-induced hepatic steatosis and adipocyte hypertrophy. No detectable toxicity was observed in cis-vaccenic acid-treated mice. These findings suggest that cis-vaccenic acid may represent a novel therapeutic target for obesity management and related metabolic disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106958"},"PeriodicalIF":3.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of radish (Raphanus sativus) green extract on the intestinal mucus secretion and prebiotic activity 萝卜绿提取物对肠道粘液分泌和益生元活性的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-12 DOI: 10.1016/j.jff.2025.106956

Wonchan Yoon , Hye-Bin Lee , Seong Un Jeong , Duyun Jeong , Miri Park , Sang Hoon Lee , Young-Soo Kim , Ho-Young Park

{"title":"Effects of radish (Raphanus sativus) green extract on the intestinal mucus secretion and prebiotic activity","authors":"Wonchan Yoon , Hye-Bin Lee , Seong Un Jeong , Duyun Jeong , Miri Park , Sang Hoon Lee , Young-Soo Kim , Ho-Young Park","doi":"10.1016/j.jff.2025.106956","DOIUrl":"10.1016/j.jff.2025.106956","url":null,"abstract":"<div><div>Dietary imbalances and consumption of highly processed foods can compromise the gut microbiota and weaken intestinal barrier integrity, contributing to leaky gut syndrome. This study aimed to assess the efficacy of radish green extract (RGE) in supporting intestinal health and identify related biomarkers. Using a simulated gastrointestinal model, we evaluated RGE's microstructure changes and its <em>in vitro</em> prebiotic activity. The physiological effects were further examined in mice with obesity induced by a Western diet. RGE supported the proliferation of three probiotic strains, both before and after digestion. In LS174T cells, RGE stimulated MUC2 gene expression. In animal experiments, RGE improved gut barrier function, reduced systemic inflammation, and enhanced microbial diversity. These results suggest that RGE preserves its beneficial properties through digestion and holds promise as a functional food for managing metabolic dysfunction <em>via</em> gut health modulation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106956"},"PeriodicalIF":3.8,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and potential application of slowly digestible starch 慢消化淀粉的合成及其应用前景

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-11 DOI: 10.1016/j.jff.2025.106955

Huyen Thi Thanh Doan , Taeok Kim , Minseok Cha , Soo-Jung Kim

引用次数: 0