Journal of Functional Foods最新文献_第2页

Effects of different probiotics on the flavor nutritional profile, and immune modulation of soy whey carrot beverage in mice 不同益生菌对小鼠大豆乳清胡萝卜饮料风味、营养成分及免疫调节的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-28 DOI: 10.1016/j.jff.2025.106781

Dayu Zhou , Caiyun Chu , Hongchuang Yuan , Miao Bai , Yuwei Men , Manirambona Télesphore , Xiangxiang Ren , Shiyuan Zhang , Xiaohui Zhao , He Liu

{"title":"Effects of different probiotics on the flavor nutritional profile, and immune modulation of soy whey carrot beverage in mice","authors":"Dayu Zhou , Caiyun Chu , Hongchuang Yuan , Miao Bai , Yuwei Men , Manirambona Télesphore , Xiangxiang Ren , Shiyuan Zhang , Xiaohui Zhao , He Liu","doi":"10.1016/j.jff.2025.106781","DOIUrl":"10.1016/j.jff.2025.106781","url":null,"abstract":"<div><div>In this study, a probiotic fermented beverage was prepared from soy whey and carrot (unfermented, single-strain, double-strain, and triple-strain fermented), and its antioxidant and immunomodulatory activities were investigated. Gas chromatography-mass spectrometry(GC–MS) and amino acid analysis revealed that ester content increased from 1.60 × 10<sup>−4</sup> μg/mL to 3.34 × 10<sup>−4</sup> μg/mL after fermentation with three bacterial strains, compared to the unfermented control. The •OH scavenging capacity increased from 28 % to 92 %. Mouse experiments showed that the fermented beverages significantly affected immune cell levels, with each bacterial strain inducing distinct immunomodulatory effects. Short-term stimulation of cytotoxicity and helper T-cell proliferation was observed after ingestion, along with long-term increases in natural killer cells and memory T-cell counts. This study addressed critical knowledge gaps regarding the efficacy of fermented beverages and provides a theoretical and technical foundation for the high-value utilization of soy by-products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106781"},"PeriodicalIF":3.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological activities and health benefits of sodium alginate: A review 海藻酸钠的生物活性及其健康益处

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-28 DOI: 10.1016/j.jff.2025.106856

Xinru Li , Yi Qiao , Hui Liu

引用次数: 0

Restorative potential of Phoenix dactylifera fruit and extract against oxidative stress mediated cardiac dysfunction in rodent experimental modeling 凤凰果及其提取物对氧化应激介导的小鼠心功能障碍的修复作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-26 DOI: 10.1016/j.jff.2025.106845

Kanza Aziz Awan , Iahtisham-Ul-Haq , Masood Sadiq Butt , Hussan Munir , Waleed Sultan , Sanabil Yaqoob , Gulzar Ahmad Nayik , Aanchal Sharma , Gadah Albasher , Mohammad Javed Ansari , Attila Gere

{"title":"Restorative potential of Phoenix dactylifera fruit and extract against oxidative stress mediated cardiac dysfunction in rodent experimental modeling","authors":"Kanza Aziz Awan , Iahtisham-Ul-Haq , Masood Sadiq Butt , Hussan Munir , Waleed Sultan , Sanabil Yaqoob , Gulzar Ahmad Nayik , Aanchal Sharma , Gadah Albasher , Mohammad Javed Ansari , Attila Gere","doi":"10.1016/j.jff.2025.106845","DOIUrl":"10.1016/j.jff.2025.106845","url":null,"abstract":"<div><div>The study evaluates the cardioprotective effects of date fruit (<em>Phoenix dactylifera</em>) and its extract against oxidative stress-induced cardiac dysfunction in a rat model. Date extract was more effective than whole fruit in reducing serum cardiac stress biomarkers. AST levels decreased by 19 % with the extract and 14.47 % with whole fruit, while CK declined by 3.80 % and 2.34 %, respectively. LDH levels dropped by 22.51 % with extract and 16.01 % with fruit, and CK-MB improved by 18.02 % in the extract-treated group. Antioxidant enzyme activity increased significantly, with SOD rising by 38.34 % and CAT by 35.71 %, while lipid peroxidation (MDA) decreased by 25.67 %. Histopathological analysis showed better myocardial structure with less congestion, necrosis, and inflammation, especially in the extract group. Hematological parameters remained unchanged. These findings indicate that date fruit and its extract may help mitigate oxidative stress-induced cardiac dysfunction. Further research is required to understand their molecular mechanisms and clinical potential.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106845"},"PeriodicalIF":3.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential improvement of Isaria cicadae Miquel spores oil(ICSO)alleviate TNBS-induced fibrosis of Caco-2 cells by down-regulating the activation of EGFR and SRC in the MEK/ERK and PI3K/Akt pathways 蝉蜕孢子油（ICSO）通过下调MEK/ERK和PI3K/Akt通路中表皮生长因子受体（EGFR）和表皮生长因子转化酶（SRC）的活化，减轻TNBS诱导的Caco-2细胞纤维化的潜在改善作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-26 DOI: 10.1016/j.jff.2025.106850

Beiqi Wang , Hui Cao , Chao Guo , Ruilian Yu , Li Xu , Xuexiang Liu , Qin Wang , Yangjie Shao

{"title":"Potential improvement of Isaria cicadae Miquel spores oil(ICSO)alleviate TNBS-induced fibrosis of Caco-2 cells by down-regulating the activation of EGFR and SRC in the MEK/ERK and PI3K/Akt pathways","authors":"Beiqi Wang , Hui Cao , Chao Guo , Ruilian Yu , Li Xu , Xuexiang Liu , Qin Wang , Yangjie Shao","doi":"10.1016/j.jff.2025.106850","DOIUrl":"10.1016/j.jff.2025.106850","url":null,"abstract":"<div><div>The natural oil extracted from Isaria cicadae Miquel (ICSO), a rare mushroom species, has demonstrated efficacy in alleviating intestinal fibrosis associated with Crohn's disease (CD), although its precise mechanisms remain unclear. This study employed an integrated approach combining network pharmacology, molecular docking, and experimental validation to investigate ICSO's therapeutic potential. ICSO obtained through Soxhlet extraction was characterized by GC–MS, revealing 21 components including 16 fatty acids (84.82 % of total composition). In a TNBS-induced Caco-2 cell fibrosis model, ICSO (20-200 μg/mL) dose-dependently attenuated intestinal fibrosis, significantly reducing hydroxyproline accumulation (<em>P</em> < 0.05) and suppressing type I and II collagen deposition (<em>P</em> < 0.01). Furthermore, Consistent with network pharmacology predictions, ICSO (50, 100, and 200 μg/mL) markedly inhibited EGFR overexpression, suppressed SRC activation, while downregulating AKT (<em>P</em> < 0.001) and MAPK1 phosphorylation (<em>P</em> < 0.05). These coordinated mechanisms effectively ameliorated epithelial-mesenchymal transition (EMT) and prevented intestinal fibrosis progression in CD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106850"},"PeriodicalIF":3.8,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hericium erinaceus extract attenuates gastric mucosal injury via Nrf2/HO-1 pathway activation and gut microbiota modulation in rats 猴头菌提取物通过激活Nrf2/HO-1通路和调节肠道菌群减轻大鼠胃黏膜损伤

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-25 DOI: 10.1016/j.jff.2025.106842

Feng Zhu , Hongye Pan , Bin Li , Xiaoping Mao , Zhilin Chen , Guanzeng Ye , Jiawen Gao , Yujia Shen , Jiangning Hu , Zhaohuan Lou

{"title":"Hericium erinaceus extract attenuates gastric mucosal injury via Nrf2/HO-1 pathway activation and gut microbiota modulation in rats","authors":"Feng Zhu , Hongye Pan , Bin Li , Xiaoping Mao , Zhilin Chen , Guanzeng Ye , Jiawen Gao , Yujia Shen , Jiangning Hu , Zhaohuan Lou","doi":"10.1016/j.jff.2025.106842","DOIUrl":"10.1016/j.jff.2025.106842","url":null,"abstract":"<div><div><em>Hericium erinaceus</em> is a well-known medicinal-edible fungus widely utilized in the treatment of gastrointestinal disorders. This study aims to investigate the preventive and therapeutic effects of <em>Hericium erinaceus</em> extract (HEE) on gastric mucosal lesions and to explore the mechanisms underlying its action. HEE was administered by gavage to rats before they were treated with absolute ethanol. Histological examination and assessment of antioxidant capacity demonstrated that HEE significantly alleviated the severity of gastric mucosal injury and enhanced the activity of antioxidant enzymes. Quantitative PCR (qPCR) analysis revealed that HEE modulated the Nrf2 signaling pathway. HEE treatment of ethanol injured GES-1 cells showed that HEE reduces malondialdehyde (MDA) levels while simultaneously increasing superoxide dismutase (SOD) and glutathione (GSH) activities. Immunoblot results indicated that HEE could activate Nrf2 and increase HO-1 protein expression in vitro. A rat model induced by acetic acid was established to investigate the ability of HEE to treat gastric ulcers. HEE effectively reduced the gastric ulcer area and enhanced gut microbiome diversity. These findings show that <em>Hericium erinaceus</em> extract is a potential therapeutic agent, and its mechanisms for preventing and treating gastric mucosal injury may involve enhancing antioxidant capacity, regulating the Nrf2 pathway and modulating gut microbiota.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106842"},"PeriodicalIF":3.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond traditional uses: Unveiling the epigenetic, microbiome-modulating, metabolic, and nutraceutical benefits of Salvia officinalis in human and livestock nutrition 超越传统用途：揭示鼠尾草在人类和牲畜营养中的表观遗传，微生物组调节，代谢和营养保健益处

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-25 DOI: 10.1016/j.jff.2025.106843

Mohamed E. Abd El-Hack , Hassan A. Rudayni , Ahmed K. Aldhalmi , Islam M. Youssef , Muhammad Arif , Abdullah S. Alawam , Ahmed A. Allam , Asmaa F. Khafaga , Elwy A. Ashour , Mohammad M.H. Khan

{"title":"Beyond traditional uses: Unveiling the epigenetic, microbiome-modulating, metabolic, and nutraceutical benefits of Salvia officinalis in human and livestock nutrition","authors":"Mohamed E. Abd El-Hack , Hassan A. Rudayni , Ahmed K. Aldhalmi , Islam M. Youssef , Muhammad Arif , Abdullah S. Alawam , Ahmed A. Allam , Asmaa F. Khafaga , Elwy A. Ashour , Mohammad M.H. Khan","doi":"10.1016/j.jff.2025.106843","DOIUrl":"10.1016/j.jff.2025.106843","url":null,"abstract":"<div><div>Sage (<em>Salvia officinalis</em>), a member of the Lamiaceae family, has a long history of medicinal use for conditions such as diarrhea, rheumatism, ulcers, gout, and inflammation. While its traditional and culinary applications are well documented, recent research highlights its potential as a metabolic modulator, microbiome regulator, epigenetic influencer, and pharmacological agent. However, its full impact on human and livestock nutrition remains underexplored. This review examines the role of sage in functional foods, precision livestock feeding, and drug development, emphasizing its influence on gene expression, gut microbiota, metabolic efficiency, and nutraceutical formulations. By integrating nutrigenomics, microbiome engineering, metabolomic profiling, and pharmacological research, we propose a next-generation framework for utilizing sage to enhance health, resilience, and productivity in both human and veterinary applications.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106843"},"PeriodicalIF":3.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The antioxidant strain Lactiplantibacillus plantarum BX62 alleviates rheumatoid arthritis via balancing immune homeostasis and modulating NLRP3/Caspase-1/IL-1β and AKT/mTOR pathways 抗氧化菌株planplantibacillus plantarum BX62通过调节NLRP3/Caspase-1/IL-1β和AKT/mTOR通路，平衡免疫稳态，缓解类风湿关节炎

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-24 DOI: 10.1016/j.jff.2025.106832

Qiang Li , Zitong Ding , Hu Chen , Mengya Jia , Samaila Usman , Qi Liu , Mengyan Chen , Tingtao Chen , Azmat Ullah Jan , Qi Qin , Xusheng Guo

{"title":"The antioxidant strain Lactiplantibacillus plantarum BX62 alleviates rheumatoid arthritis via balancing immune homeostasis and modulating NLRP3/Caspase-1/IL-1β and AKT/mTOR pathways","authors":"Qiang Li , Zitong Ding , Hu Chen , Mengya Jia , Samaila Usman , Qi Liu , Mengyan Chen , Tingtao Chen , Azmat Ullah Jan , Qi Qin , Xusheng Guo","doi":"10.1016/j.jff.2025.106832","DOIUrl":"10.1016/j.jff.2025.106832","url":null,"abstract":"<div><div>This study explored the effect of antioxidant <em>Lactiplantibacillus plantarum</em> BX62 (2×10<sup>9</sup>CFU/ml) on RA and elucidated its underlying mechanisms using a collagen induced arthritis rat model. Results showed <em>L. plantarum</em> BX62 reduced oxidative stress, decreased the levels of inflammatory cytokines in the serum, and increased anti-inflammatory interleukin-10 levels. Bone damage mitigation was confirmed via histology and micro-computed tomography analyses. Furthermore, <em>L. plantarum</em> BX62 restored immune balance and CD4+/CD8+ T cell ratio in the spleen. Downregulations of NLRP3, Cleaved Caspased-1, Cleaved IL-1β, RANKL, p-AKT, p-mTOR, and p62, and upregulations of OPG and Beclin-1 proteins were also observed in <em>L</em>. <em>plantarum</em> BX62 group. Meanwhile, The stable organ coefficients of <em>L. plantarum</em> BX62 demonstrated its safety for oral administration. Overall, <em>L. plantarum</em> BX62 demonstrated preventive effects against RA progression by reducing oxidative stress, modulating NLRP3/Caspase-1/IL-1β, AKT/mTOR pathways, balancing autophagy, and enhancing bone protection; thus, making it a formidable probiotic strain for curing RA.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106832"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology 副干酪乳杆菌发酵枸杞汁通过抑制炎症和调节肠道微生态改善小鼠便秘

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-24 DOI: 10.1016/j.jff.2025.106841

Xiaoyu He , Yu Zhang , Haitian Fang , Ni Ma , Xueni Yan , Huabing Yang , Lu Cao , Lu Xu , Haiming Hu , Hongtao Liu

{"title":"Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology","authors":"Xiaoyu He , Yu Zhang , Haitian Fang , Ni Ma , Xueni Yan , Huabing Yang , Lu Cao , Lu Xu , Haiming Hu , Hongtao Liu","doi":"10.1016/j.jff.2025.106841","DOIUrl":"10.1016/j.jff.2025.106841","url":null,"abstract":"<div><div>This study investigated the effects of <em>Lactobacillus paracasei</em> (<em>L. paracasei</em>)-fermented Goji juice supernatant (FGS) on constipation. GC–MS data showed that the critical metabolites of FGS were nicotinamide, squalene, L-proline, melatonin, and sarcosine. FGS intervention significantly promoted intestinal peristalsis. Meanwhile, FGS ameliorated intestinal inflammation and mucosal barrier damage by inhibiting the expressions of pro-inflammatory factors (TNF-α, IL-1β, COX-2), promoting the expressions of Mucin 1, Mucin 3, ZO-1, AQP4, and ENac-γ. In addition, FGS treatment modulated gut microbiota composition, reduced the abundance of harmful bacteria (<em>Faecalibaculum</em>, <em>Bacteroides</em>, <em>Alloprevotella</em> and <em>Alistipes</em>), induced a bloom of probiotics, including <em>Marvinbryantia</em>, <em>Eubacterium</em>_<em>xylanophilum</em>_group, <em>Colidextribacter</em>, and <em>Candidatus</em>_<em>Soleaferrea</em>. Conclusively, this study demonstrated that FGS significantly reduced inflammatory response, prevented intestinal barrier damage, and modulated microbiota dysbiosis to improve constipation. Compared to unfermented Goji juice (UFGJ), FGS has shown a more effective anti-constipation effect, indicating that FGS could relieve constipation as a dietary therapeutic.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106841"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure 印尼无刺蜂Geniotrigona胸腔蜂胶提取物在改善肥胖和调节炎症和自噬过程中的作用后，手掌为基础的高脂肪饮食暴露

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-24 DOI: 10.1016/j.jff.2025.106831

Andreas Christoper , Elvine Gunawan , Herry Herman , Rizky Abdulah , Felix Zulhendri , Milena Popova , Boryana Trusheva , Vassya Bankova , Ronny Lesmana

{"title":"The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure","authors":"Andreas Christoper , Elvine Gunawan , Herry Herman , Rizky Abdulah , Felix Zulhendri , Milena Popova , Boryana Trusheva , Vassya Bankova , Ronny Lesmana","doi":"10.1016/j.jff.2025.106831","DOIUrl":"10.1016/j.jff.2025.106831","url":null,"abstract":"<div><div>Obesity is a global health problem that can lead to organ damage, particularly affecting brain function. This study aims to investigate the role of Indonesian propolis extract in mitigating neuroinflammation following a prolonged high-fat diet. The experiment used four groups of Wistar rats: Normal chow diet (NCD), Normal chow diet with Propolis (NCP), High-fat diet (HFD), and High-fat diet with Propolis (HFP). The experiment was conducted for 21 weeks of a high-fat diet, with propolis administrated during the last nine weeks. The propolis extract used in the study predominantly contained triterpenoids, including cycloartenol, amyrenone, and mangiferolic acid. The rats were sacrificed with the prefrontal cortex collected at the end of the study. Cortical inflammatory cytokines IL-1β, IL-6, and TNF-α were analyzed using Multiplex Immunoassay, whereas autophagy proteins LC3 and ATG5 were examined using Western Blot. The mean body weight of the HFP was lower than that of the HFD. The HFP revealed lower IL-1β, TNF-α, and LC3-II levels, but greater ATG5 and IL-6 levels than the HFD. These findings suggest that propolis may help preserve neurological function by reducing inflammation after a long-term high-fat diet through weight reduction and restoration of autophagy function.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106831"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect and pathways of the selenylation-modified nondigestive longan (Dimocarpus longan Lour.) polysaccharides in IEC-6 cells with indomethacin injury 硒化修饰的非消化性龙眼多糖对吲哚美辛损伤ec -6细胞的保护作用及其途径

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-23 DOI: 10.1016/j.jff.2025.106833

Ya-Hui Yu , Xin-Huai Zhao

{"title":"Protective effect and pathways of the selenylation-modified nondigestive longan (Dimocarpus longan Lour.) polysaccharides in IEC-6 cells with indomethacin injury","authors":"Ya-Hui Yu , Xin-Huai Zhao","doi":"10.1016/j.jff.2025.106833","DOIUrl":"10.1016/j.jff.2025.106833","url":null,"abstract":"<div><div>Covalent combination of Se with natural polysaccharides provides bioactive organic Se strategically. Thus, nondigestive longan (<em>Dimocarpus longan</em> Lour.) polysaccharides (LP) were selenylation-modified to obtain SeLP1 and SeLP2 with Se contents of 1.46 and 4.79 g/kg. SeLP1, SeLP2, and LP (as control) were assessed for their activities in IEC-6 cells exposed to indomethacin. Compared with LP, SeLP1 and especially SeLP2 were more active in ameliorating the indomethacin-induced cytotoxicity and oxidative stress, <em>via</em> increasing cell viability, decreasing lactate dehydrogenase release and ROS production, and reducing mitochondrial membrane potential loss. Both SeLP1 and SeLP2 were more potent than LP in alleviating the induced barrier disruption, causing rescued barrier integrity and up-regulated three tight junction-related genes and proteins. Additionally, both SeLP1 and SeLP2 ameliorated barrier dysfunction by suppressing MAPK- and mitochondrial apoptosis-mediated signaling pathways. Collectively, this selenylation and higher selenylation extent endowed SeLP2 with higher activity in ameliorating the indomethacin-caused cytotoxicity and barrier disruption.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106833"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0