Journal of Functional Foods最新文献

{"title":"Preparation, structural characterization, and performance evaluation of antler plate collagen peptide-calcium chelates","authors":"Baiqiang Wu ,&nbsp;Jianing Sun ,&nbsp;Yu Jiao ,&nbsp;Mei Yang ,&nbsp;Mengjie Dong ,&nbsp;Wei Hu","doi":"10.1016/j.jff.2025.106953","DOIUrl":"10.1016/j.jff.2025.106953","url":null,"abstract":"<div><div>This study investigated the preparation conditions, stability, calcium absorption characteristics, anti-osteoporotic activity, and chelation properties of antler plate collagen peptide‑calcium chelates (APCP-Ca). The high-affinity calcium chelate peptide monomer was isolated and purified from APCP-Ca, and its structure was characterized by molecular docking, molecular dynamics simulation, scanning electron microscopy, atomic force microscopy, X-ray spectroscopy and Fourier transform infrared spectroscopy. The results indicated that the optimal chelation conditions for APCP-Ca were as follows: peptide-to‑calcium ratio of 3:1, temperature of 50 °C, time of 50 min, and pH of 7.0. APCP-Ca exhibited thermal stability and pH stability, enhanced calcium transport in Caco-2 cells, and regulated key serum bone turnover markers, improving bone density in osteoporotic rats. A novel calcium-chelating peptide monomer GG10-Ca was obtained from APCP-Ca. The structural characterization results demonstrated that GG10-Ca was a novel and more densely packed crystal structure. APCP-Ca is a new type of calcium supplement with high bioavailability.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106953"},"PeriodicalIF":3.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory mechanisms of flavonoids in Pueraria lobata: Immune cell regulation and molecular mechanisms","authors":"Xiao-Wei Meng ,&nbsp;Qian-Qian Wang ,&nbsp;Ni Zhang ,&nbsp;Feng-Mei Guo ,&nbsp;Jia-Rong Li ,&nbsp;Qing Zhu ,&nbsp;Rong-Hua Liu ,&nbsp;Wei-Feng Zhu","doi":"10.1016/j.jff.2025.106954","DOIUrl":"10.1016/j.jff.2025.106954","url":null,"abstract":"<div><div>Inflammation is a fundamental pathogenic process in various kinds of disorders, and excessive activation can result in tissue damage and chronic disease development. <em>Pueraria lobata</em> is a medicinal and edible herb, highly valued for its food, medicinal, and economic properties, with extensive potential applications. Extensive research indicates that the flavonoids in <em>Pueraria lobata</em> exhibit significant anti-inflammatory potential. These flavonoids primarily modulate macrophage polarization and phagocytosis, regulate T cell homeostasis, inhibit neutrophil infiltration, control the release of inflammatory cytokines and mediators, influence signaling pathways, alter miRNA expression, and regulate intestinal flora. Through these diverse mechanisms, they mitigate various inflammatory diseases. This paper systematically reviews the recent research advancements regarding flavonoids in <em>Pueraria lobata</em>, focusing on immune cell regulation and molecular mechanisms, to offer a theoretical foundation for further investigation into the anti-inflammatory properties of these flavonoids and the development and utilization of <em>Pueraria lobata</em> products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106954"},"PeriodicalIF":3.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of lipids of Irish marine cyanobacteria Chlorogloea microcystoides SABC 022904 and Phormidium africanum SABC 022001","authors":"Katie Shiels ,&nbsp;Joana Silva ,&nbsp;Celso Alves ,&nbsp;Rui Pedrosa ,&nbsp;Patrick Murray ,&nbsp;Sushanta Kumar Saha","doi":"10.1016/j.jff.2025.106952","DOIUrl":"10.1016/j.jff.2025.106952","url":null,"abstract":"<div><div>Parkinson's disease (PD) is a progressive neurodegenerative disorder linked to dopaminergic neuron loss and chronic neuroinflammation. This study investigated the neuroprotective and anti-inflammatory effects of lipids from Irish marine cyanobacteria, <em>Chlorogloea microcystoides</em> and <em>Phormidium africanum</em>. These lipids contain fatty acids including oleic, linoleic, and linolenic acids. Under PD-mimicking conditions (induced by oxidative stress in neuroblastoma cells), lipids from <em>C. microcystoides</em> significantly reduced cell death and oxidative damage at 10–30 μg/mL. Anti-inflammatory activities were assessed using RAW 264.7 macrophages stimulated with lipopolysaccharide, showing that both cyanobacterial lipids reduced nitric oxide production and altered cytokine levels. Importantly, <em>C. microcystoides</em> lipids decreased IL-6 and increased anti-inflammatory IL-10. These results suggest particularly that the lipids of <em>C. microcystoides</em> hold promise as a therapeutic additive in foods to mitigate oxidative stress and neuroinflammation in PD due to their neuroprotective and anti-inflammatory properties.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106952"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Akkermansia muciniphila YGMCC2602-derived postbiotics in skin repair","authors":"Zhili He ,&nbsp;Wenfang Song ,&nbsp;Shichang Zhang ,&nbsp;Minlei Zhao ,&nbsp;Fan Wang ,&nbsp;Shanshan He ,&nbsp;Xiaochi Jie ,&nbsp;Qi Gao ,&nbsp;Jianguo Chen","doi":"10.1016/j.jff.2025.106950","DOIUrl":"10.1016/j.jff.2025.106950","url":null,"abstract":"<div><div>Skin aging, wrinkles, dryness, and inflammation have been of great concern and the development of non-toxic natural skin care products is of great importance. In this study, we investigated for the role of three postbiotics (cell-free supernatant, bacterial lysate, and extracellular vesicles) from <em>Akkermansia muciniphila</em> YGMCC2602 in skin health. In vitro experiments showed that these postbiotics promoted HSF cell proliferation and migration, and upregulated the expression of collagen (<em>COL17A1</em>, <em>COL1A1</em>, <em>COL3A1</em>) and hyaluronan synthase (<em>HAS1</em>). The bacterial lysate and extracellular vesicles also attenuated ultraviolet B-induced inflammation, reactive oxygen species accumulation, and apoptosis in HaCaT Cells, thereby mitigating photodamage. In addition, the bacterial lysate exhibited immunosuppressive effects in lipopolysaccharides-induced Raw 264.7 cells and alleviated skin redness and water loss, while increasing stratum corneum moisture content in human skin. In summary, the bacterial lysate of YGMCC2602 significantly alleviated skin aging, dryness, and inflammation, providing a candidate ingredient for skin care or functional food.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106950"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spirulina supplementation and its effects on inflammation and oxidative stress: A systematic review and Meta-analysis on randomized clinical trials","authors":"Samin Mousavi ,&nbsp;Afsaneh Yegdaneh ,&nbsp;Mahsa Shirani ,&nbsp;Awat Feizi ,&nbsp;Mustafa Ghanadian","doi":"10.1016/j.jff.2025.106945","DOIUrl":"10.1016/j.jff.2025.106945","url":null,"abstract":"<div><div>The study aimed to assess the effects of <em>Spirulina</em> as a supplementary treatment for inflammatory conditions amidst ongoing debates regarding its benefits for healthy individuals and patients.</div><div>This systematic review and meta-analysis included 22 studies with 5385 participants, utilizing databases such as Scopus, Google Scholar, PubMed-Medline, and Web of Science, covering the period from 1995 to August 2024.</div><div>The meta-analysis demonstrated that <em>Spirulina</em> supplementation significantly reduced inflammatory biomarkers, including CRP levels (SMD: −0.972 mg/dl), interleukin-6 (SMD: −0.532), and TNF-α (SMD: −0.579 mg/dl). Furthermore, oxidative stress biomarkers showed a significant decrease in malondialdehyde (SMD: −0.929) and an increase in total antioxidant capacity (SMD: 1.086).</div><div>The findings strongly advocate for <em>Spirulina</em> as a valuable dietary supplement for both healthy individuals and patients, aiming to lower inflammatory markers and enhance antioxidant capacity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106945"},"PeriodicalIF":3.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insoluble dietary fiber from Chinese cabbage leaves improves glucose and lipid metabolism disorders in HFD-fed mice by mediating gut microbiota","authors":"Ya-Die Niu ,&nbsp;Qian Zhou ,&nbsp;Zhe Gao ,&nbsp;Liang-Fu Zhou ,&nbsp;Li-Jun Song ,&nbsp;Wen Zhao ,&nbsp;Ya-Sai Sun","doi":"10.1016/j.jff.2025.106948","DOIUrl":"10.1016/j.jff.2025.106948","url":null,"abstract":"<div><div>Long term high-fat diet lead to glucose and lipid metabolism disorders (GLMD). Here, we investigated the effect of insoluble dietary fiber extracted from Chinese cabbage leaves (CIDF) on GLMD. Firstly, CIDF, containing 68.55 % insoluble dietary fiber, was extracted by complex enzyme. Experiments confirmed that CIDF had polysaccharide functional groups with preferable water holding and swelling capacity, glucose and lipids absorption, and relevant enzymes inhibition. Secondly, C57BL/6J mice were fed with LFD, HFD, HFD + 250 mg/kg·body weight CIDF (CIDF-L) and HFD + 500 mg/kg·body weight CIDF (CIDF-H), respectively. After 12-week intervention, CIDF significantly ameliorated serum lipid profile, glucose intolerance, and insulin resistance, which might achieved by promoting the conversion of cholesterol to bile acids (PPARα-LXRα-CYP7A1) and liver glycogen synthesis (PPARγ-PI3K-AKT). Finally, 16S rRNA implied that CIDF improved GLMD by reducing the abundance of <em>Biophilia</em>. In summary, CIDF is expected as a dietary supplement for GLMD amelioration, which is meaningful for promoting its comprehensive utilization.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106948"},"PeriodicalIF":3.8,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144514221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction of the dietary antioxidant status indices and paraoxonase1 rs662 polymorphism on the lipid profile and severity of coronary artery stenosis in adults undergoing coronary angiography","authors":"Mina Darand ,&nbsp;Mohammad Haji Aghajani ,&nbsp;Vahid Arabi ,&nbsp;Fatemeh Sadat Mirjalili ,&nbsp;Matin Mohyadini ,&nbsp;Amin Salehi-Abargouei","doi":"10.1016/j.jff.2025.106935","DOIUrl":"10.1016/j.jff.2025.106935","url":null,"abstract":"<div><h3>Background and aim</h3><div>The inconsistency in the results of studies related to the effect of dietary antioxidant factors on the state of health and disease prompted us to investigate the interaction of dietary antioxidant indices—namely the Dietary Antioxidant Index (DAI), the Dietary Antioxidant Quality Score (DAQS) and the Dietary Phytochemical Index (DPI)—and the paraoxonase1(PON1) rs662 polymorphism on lipid profile markers and severity of coronary stenosis.</div></div><div><h3>Methods and results</h3><div>This cross-sectional study was conducted on 425 patients undergoing angiography. The <em>PON1</em> genotypes (QQ, QR, and RR) were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. To compare individuals based on the presence of the dominant allele, the population is divided into two groups: those lacking the dominant allele (QQ) and those carrying at least one copy of the dominant allele (genotypes QR or RR). Dietary intake was evaluated using a Food Frequency Questionnaire (FFQ).</div></div><div><h3>Results</h3><div>Accordingly, high adherence to the DAI decreased the odds of low HDL-C in R allele carriers compared to QQ genotype carriers by 0.64 (OR: 0.36, 95 % CI 0.15–0.86, <em>P</em> = 0.02). This interaction remained statistically significant after adjustment for age, gender, energy intake, physical activity, smoking, medication use, BMI, and married status (P interaction = 0.05). There was a significant interaction between the rs662 variants and the DAQS on the risk of severe coronary artery disease in the crude model (<em>P</em> = 0.02) but not in the adjusted model. Also, there was an interaction between adherence to DPI and variants of rs662 on odds of high triglyceride (<em>P</em> interaction = 0.03). Based on these interactions, when adherence to the DPI was high, R allele carriers had lower odds of high triglyceride than those with the QQ genotype (OR 0.33, 95 %CI 0.12–0.87; <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>R allele carriers may more benefit from consuming a diet high in antioxidants, than QQ genotype carriers concerning high triglycerides and low-HDL-C.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106935"},"PeriodicalIF":3.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using transcriptomics to investigate the effects of infant formulae on the growth and development of small intestinal organoids and Caco2 cells","authors":"Xianli Wang ,&nbsp;Yuxin Jing ,&nbsp;Chengdong Zheng ,&nbsp;Chenxuan Huang ,&nbsp;Haiyang Yao ,&nbsp;Zening Wang ,&nbsp;Kainan Huang ,&nbsp;Yuanyuan Yan ,&nbsp;Shilong Jiang ,&nbsp;Jianguo Sun ,&nbsp;Qinggang Xie ,&nbsp;Yongjiu Zhang ,&nbsp;Xiaoguang Li ,&nbsp;Hui Wang","doi":"10.1016/j.jff.2025.106951","DOIUrl":"10.1016/j.jff.2025.106951","url":null,"abstract":"<div><div>Infant formula serves as a crucial breast milk alternative, yet its molecular mechanisms remain poorly understood. Small intestinal organoids (SIOs) are in vitro-cultured, multicellular structures and have been applied in diverse research fields. Nevertheless, SIOs have not been used in formula studies, nor have comparisons been made between SIOs and traditional models. This study pioneered using SIOs alongside Caco-2 cells to investigate formula's effects through transcriptomics and RT-qPCR. Formula upregulated proliferation, differentiation, and structural pathways in both models. Comparative analysis (GO/KEGG/IPA) revealed SIOs enhanced protein metabolism, mucin/peptide secretion, and immune responses versus Caco-2 cells, with key pathway genes identified. Notably, lactoferrin and <em>Bifidobacterium lactis</em> synergistically improved extracellular matrix development and immune signaling. These findings provide mechanistic evidence of formula's cellular impacts using SIOs, establishing their superiority over traditional models for nutritional research. Our work offers novel insights for formula optimization while demonstrating SIOs' potential as an advanced intestinal model system.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106951"},"PeriodicalIF":3.8,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan lactate mitigates metabolic-associated fatty liver disease via TGR5-mediated anti-inflammatory mechanisms and the gut-hepatic-bile acid axis","authors":"Yiyu Lin ,&nbsp;Weijun Lun ,&nbsp;Yan Bai ,&nbsp;Qishi Che ,&nbsp;Hua Cao ,&nbsp;Jiao Guo ,&nbsp;Zhengquan Su","doi":"10.1016/j.jff.2025.106946","DOIUrl":"10.1016/j.jff.2025.106946","url":null,"abstract":"<div><div>As a derivative of chitosan, chitosan lactate (CTL) not only maintains the good biological activity of chitosan, but also effectively improves the water-insoluble characteristics of chitosan. We used CTL to intervene in metabolic-related fatty liver disease (MAFLD) model mice, observed the effect of CTL on MAFLD mice, and detected the expression of TGR5-PKA pathway and classical inflammatory pathway-related proteins in mouse liver. The intestinal flora and bile acids of mice were further analyzed. The results showed that CTL had good therapeutic activity against MAFLD, inhibited the activation of NF-κB inflammatory pathway in liver through TGR5-PKA-IκBα-p65 and TGR5-PKA-CREB pathways, and improved the intestinal flora structure and bile acid profile of MAFLD mice. This study shows that CTL improves high-fat diet-induced liver inflammation in MAFLD mice by regulating liver inflammation pathways, intestinal flora and bile acid profiles, laying a foundation for the development of natural drugs for the treatment of MAFLD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106946"},"PeriodicalIF":3.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic study on the effects of acerola cherry concentrate on LPS-induced IEC-6 cell injury and Vinorelbine-induced immune function damage in zebrafish","authors":"Huilin Zhu ,&nbsp;Dingli Wang ,&nbsp;Jindan Han ,&nbsp;Ling Tong ,&nbsp;Yanqing Li ,&nbsp;Cuifeng Cao ,&nbsp;Lalai Zikela ,&nbsp;Zhuoli Yu ,&nbsp;Xinyao Li ,&nbsp;Hui Zhou ,&nbsp;Songtao Li ,&nbsp;Libing Chen ,&nbsp;Qiang Han","doi":"10.1016/j.jff.2025.106949","DOIUrl":"10.1016/j.jff.2025.106949","url":null,"abstract":"<div><div>Acerola cherry (<em>Malpighia emarginata</em> DC.), renowned for its exceptional natural vitamin C (VC) and bioactive compounds, exhibits antioxidant, anti-inflammatory, and immunomodulatory properties. This study systematically investigated the protective effects of Acerola Cherry Concentrate (AC) against LPS-induced oxidative injury in IEC-6 cells in vitro and vinorelbine-triggered immune dysfunction in zebrafish in vivo. AC significantly enhanced catalase and superoxide dismutase activities while reducing malondialdehyde (MDA) levels in IEC-6 cells, outperforming synthetic VC in mitigating LPS-induced oxidative stress. Mechanistically, AC suppressed pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) and modulated the NF-κB/TLR4/MyD88 signaling pathway, attenuating inflammatory responses. In zebrafish models, AC increased neutrophil and macrophage recruitment but showed limited enhancement of macrophage phagocytosis. Notably, the synergistic interaction between natural VC and other bioactive components in AC contributed to its synergy-enhanced efficacy. These findings underscore AC's potential as a multifunctional agent for combating oxidative stress and inflammation, offering mechanistic insights for its application in functional foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"131 ","pages":"Article 106949"},"PeriodicalIF":3.8,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}