Journal of Functional Foods最新文献

{"title":"Sustainability and nutritional aspects of traditional dishes from the Friuli Venezia Giulia region, Italy: A true cost accounting evaluation","authors":"Federica Fiori ,&nbsp;Alberto Bertossi ,&nbsp;Stefania Troiano ,&nbsp;Maria Parpinel ,&nbsp;Francesco Marangon ,&nbsp;Nicoletta Pellegrini","doi":"10.1016/j.jff.2024.106587","DOIUrl":"10.1016/j.jff.2024.106587","url":null,"abstract":"<div><div>The agrifood system needs to be redirected towards a path of sustainable development in which tradition regains its rightful place and importance. True Cost Accounting (TCA) can support this transition by translating environmental impacts into monetary terms and highlighting the hidden costs of foods. The present research combines TCA with nutritional data of traditional dishes from the Friuli Venezia Giulia region (Italy) to assess their sustainability. Results show the dishes with the highest hidden costs are those with animal proteins (beef), while those with predominant vegetable proteins have generally lower hidden costs. Specific ingredients and portion sizes were found to influence the dish impact and should be considered when developing sustainable menus or guidelines. The present study can pave the way for further studies designed to consider actual environmental indexes of local origin foods and food preparations and to summarize them in a single economic indicator, such as true cost.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106587"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced anti-inflammatory effects and metabolic profiles of cyanidin-3-glucoside via nanoliposomal encapsulation in Caco-2 and RAW 264.7 co-culture system","authors":"Hao Zhong ,&nbsp;Xin Luo ,&nbsp;Mengyu Yang ,&nbsp;Bo Zhao ,&nbsp;Xiaofeng Liu ,&nbsp;Muhammad Hussain ,&nbsp;Chaofan Hu ,&nbsp;Abdullah ,&nbsp;Rongfa Guan","doi":"10.1016/j.jff.2024.106588","DOIUrl":"10.1016/j.jff.2024.106588","url":null,"abstract":"<div><div>Cyanidin-3-glucoside (C3G) has been found to prevent/treat intestinal disease and maintain gut homeostasis. Numerous studies have proved that nanoliposomes can improve the absorption and utilization of food nutrients. However, the impacts of C3G nanoliposomes (C3G-NL) are still unkown. This study investigated the effects of cyanidin-3-glucoside nanoliposomes (C3G-NL) on intestinal inflammation and permeability using a Caco-2/RAW264.7 co-culture model. ELISA and qPCR results showed that C3G-NL reduced pro-inflammatory markers, including TNF-α, IL-6, IL-8, cyclooxygenase-2, and inducible nitric oxide synthase, while inhibiting the NF-κB/MAPK pathway. C3G-NL also improved intestinal barrier integrity by increasing transepithelial electrical resistance and upregulating tight junction proteins (zonula occludens-1, occludin, claudin-1). Additionally, C3G-NL enhanced C3G metabolism, leading to the formation of intermediary metabolites like chalcone and dihydroflavonols, which contributed to the synthesis of other anthocyanins (delphinidin, peonidin, petunidin, malvidin, and pelargonidin). Overall, C3G-NL helps mitigate inflammation and restore tight junction integrity <em>via</em> metabolic regulation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106588"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the functional potential of pea-based sourdough in traditional durum wheat focaccia: Role in enhancing bioactive compounds, in vitro antioxidant activity, in vitro digestibility and aroma","authors":"Francesca Vurro ,&nbsp;Maria Santamaria ,&nbsp;Carmine Summo ,&nbsp;Antonella Pasqualone ,&nbsp;Cristina M. Rosell","doi":"10.1016/j.jff.2024.106607","DOIUrl":"10.1016/j.jff.2024.106607","url":null,"abstract":"<div><div>Legume-based sourdough is gaining momentum. This study aimed to compare the effectiveness of type I sourdough prepared with durum wheat semolina (S1), pea flour (S2) or 50:50 semolina/pea flour (S3) in improving the nutritional quality, antioxidant compounds, <em>in vitro</em> digestibility and aroma of traditional durum wheat <em>focaccia</em>. Six <em>focaccias</em> were prepared: three with 40 % of S1, S2 and S3, and three with the corresponding amount of unfermented flours. Pea sourdough increased the content of phenolic compounds (8.82 ± 0.12 mg GAE/g d.m. in <em>focaccia</em> with 40 % pea flour and 4.92 ± 0.41 mg GAE/g d.m. in unfermented semolina <em>focaccia</em>), and consequently increased the antioxidant activity. <em>Focaccias</em> with pea flour or pea sourdough were “source of protein” and “high fiber”, according to UE Reg. 1924/2006. Pea sourdough slowed down starch <em>in vitro</em> digestibility while enhancing protein digestibility and leading to a more complex volatile profile, with increased content of aldehydes, alcohols and Maillard reaction compounds.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106607"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of cognitive functions by Rumex acetosa L. against scopolamine-induced memory impairment","authors":"Dool-Ri Oh,&nbsp;Bo Yeong Mun,&nbsp;Haeju Ko,&nbsp;Yonguk Kim,&nbsp;Donghyuck Bae","doi":"10.1016/j.jff.2024.106572","DOIUrl":"10.1016/j.jff.2024.106572","url":null,"abstract":"<div><div><em>Rumex acetosa</em> L. (RA), also called sorrel, has been used in traditional medicine owing to its many of biological activities. However, molecular mechanisms underlying the ability of RA to modulate cognitive functions against memory impairment induced by scopolamine (SCO) through anti-inflammatory and -apoptotic activities have not been investigated. Memory impairment assessed using the MWM test. RA significantly decreased escape latency on the acquisition and retention trials of the training days and increased the time to enter the platform quadrant during the probe trial. Furthermore, RA significantly decreased AChE activity, pro-inflammatory cytokines concentrations and the apoptotic signaling proteins and elevated the protein concentrations of PSD-95, phosphorylated ERK1/2 and Akt in the hippocampus. Collectively, these results suggest that RA improves cognitive function in rats with SCO-induced memory impairment by regulating AChE activity and through its anti-inflammatory and anti-apoptotic effects, which associated with the upregulation of synaptic plasticity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106572"},"PeriodicalIF":3.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus paracasei FZJJH2L6 alleviates cathartic Colon via the propionic Acid-5-HT-ACh pathway","authors":"Mengxia Liang ,&nbsp;Huimin Lu ,&nbsp;Shengnan Zhu ,&nbsp;Liping Cao ,&nbsp;Zhichao Yang ,&nbsp;Linlin Wang ,&nbsp;Jianxin Zhao","doi":"10.1016/j.jff.2024.106585","DOIUrl":"10.1016/j.jff.2024.106585","url":null,"abstract":"<div><div>Cathartic colon (CC), a form of constipation induced by the chronic abuse and dependence on stimulant laxatives. The application of probiotics to alleviate related diseases has become the research hotspot. In this study, a CC model was constructed by intragastric administration of senna extract, and <em>Lactobacillus paracasei</em> CCFM1164 was used as a positive control to screen strains that can alleviate this constipation. The findings indicate that <em>Lactobacillus paracasei</em> FZJJH2L6 effectively mitigates cathartic colon. The potential mechanisms were explored from the perspectives of enteric nerve repair and intestinal barrier restoration. Results demonstrated that <em>Lactobacillus paracasei</em> FZJJH2L6 increased the content of propionic acid in feces by increasing the relative abundance of short-chain fatty acids-producing bacteria. This upregulated acetylcholine and 5-hydroxytryptamine levels in the colon, reduced intestinal inflammation, repaired the intestinal mechanical barrier, and ultimately alleviated CC. This study provides a theoretical basis for the use of probiotics in alleviating cathartic colon.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106585"},"PeriodicalIF":3.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum metabolomics reveals the anti-aging effect of royal jelly in D-galactose induced aging mice","authors":"Han Hu ,&nbsp;Guoda Lv ,&nbsp;Qiaohong Wei ,&nbsp;Xizi Liu ,&nbsp;Fan Wu ,&nbsp;Xuyuan Chao ,&nbsp;Bin Han","doi":"10.1016/j.jff.2024.106597","DOIUrl":"10.1016/j.jff.2024.106597","url":null,"abstract":"<div><div>Aging, marked by a gradual decline in physiological functions, presents significant global health challenges. While royal jelly (RJ) is known for its biological activities, its anti-aging mechanisms require further investigation. Using a D-galactose (D-gal)-induced aging mouse model, this study applied untargeted serum metabolomics to explore RJ's effects. RJ administration significantly (<em>P</em> &lt; 0.05) improved locomotor and cognitive abilities impaired by D-gal-induced aging. Metabolomic analysis showed that RJ modulates key pathways in amino acid, lipid, and nucleotide metabolism, which are essential for cellular function and energy supply. RJ enhanced the tricarboxylic acid cycle (<em>P</em> &lt; 0.05), increased essential amino acids, and elevated nucleotide availability, supporting cognitive function and energy metabolism in aging mice. Notably, RJ had a stronger effect on male mice, particularly in improving lipid and nucleotide metabolism. These findings highlight RJ's potential as a promising anti-aging intervention, warranting further investigation for therapeutic applications in aging.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106597"},"PeriodicalIF":3.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and intestinal FXR siganlling involved in the alleviation of mulberry (Morus alba L.) leaf ethanol extract on type 2 diabetes mellitus in db/db mice","authors":"Ding-xiang Li ,&nbsp;Sheng-qiu Xu ,&nbsp;Han Jiang ,&nbsp;Ya-Ting Li ,&nbsp;Yan-lin Zhao ,&nbsp;Peng Jin ,&nbsp;Shuai Ji ,&nbsp;Yan Du ,&nbsp;Dao-Quan Tang","doi":"10.1016/j.jff.2024.106600","DOIUrl":"10.1016/j.jff.2024.106600","url":null,"abstract":"<div><div>The potential mechanism of mulberry leaf against type 2 diabetes mellitus (T2DM) is not fully elucidated. Here, we hypothesized that the anti-T2DM of mulberry leaf ethanol extract (MLEE) is related to improvement of gut microbiota and bile acids (BAs) metabolism. Our results showed that MLEE alone can ameliorate glycolipid metabolism disorder, insulin resistance, and inflammation in <em>db/db</em> mice, and presents synergistic effects with metformin (MET). Furthermore, we found that MLEE altered the abundances of gut microbiota related to BAs metabolism such as <em>Colidextribacter</em>, <em>Muribaculum</em>, <em>Muribaculaceae</em>, and <em>Eubacterium_siraeum_group</em>, promoted fecal ωMCA level and thus inhibited intestinal farnesoid X receptor (FXR) gene expression, and then increased plasma glucagon-like peptide-1 (GLP-1) level. Furthermore, intestinal FXR inhibition and plasma GLP-1 level enhancing of MLEE could also be observed in antibiotic-intervened <em>db/db</em> mice. These results indicated that MLEE could alleviate T2DM via gut microbiota-BAs-intestinal FXR pathway mediated by gut microbiota and host.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106600"},"PeriodicalIF":3.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the effects of crude chicory and inulin on gut health in weaning piglets","authors":"Tushar Kulkarni ,&nbsp;Pawel Siegien ,&nbsp;Luke Comer ,&nbsp;Jimmy Vandel ,&nbsp;Gabrielle Chataigne ,&nbsp;Aurore Richel ,&nbsp;José Wavreille ,&nbsp;Benoit Cudennec ,&nbsp;Anca Lucau ,&nbsp;Nadia Everaert ,&nbsp;Rozenn Ravallec ,&nbsp;Martine Schroyen","doi":"10.1016/j.jff.2024.106578","DOIUrl":"10.1016/j.jff.2024.106578","url":null,"abstract":"<div><div>Dysfunction of the host-microbial balance and an impaired intestinal barrier can trigger inflammation and increase the antigen penetration. Inulin, commonly extracted from chicory root, is a prebiotic beneficial to gut health. The objective of this study was to compare the effect of chicory flour to inulin on gut health, few weeks after weaning. Two dose-dependent experiments (E1 and E2) were performed sequentially, each consisting of 80 castrated male piglets, weaned at day 21 and subsequently divided in 3 groups with <em>ad libitum</em> feed: control (Ctrl), inulin (INU) and crude chicory flour (CHI). For INU and CHI groups, a daily supplementation with the equated ‘inulin content’ increasing weekly was done by oral force-feeding, while the Ctrl groups received an isotonic sucrose solution. For E1, these doses were 1.5 g/day, 2 g/day and 2.5 g/day in W1, W2 and W3, respectively. For E2, these doses were 3 g/day, 4 g/day and 5 g/day in W1, W2 and W3, respectively. For each experiment at W0, W1 and W3, eight piglets per group were euthanized to assess gut structural and functional parameters. In E1, the CHI had lower average daily calorie intake (kcal/day) only at W3, while in E2 it was consistently lower than Ctrl and INU. In W3 of E2, CHI showed improved villi-to-crypt ratio and lower diarrhea occurrence than INU and Ctrl. Both supplemented groups in E2 showed higher butyrate production and lower D-xylose permeability (W3), compared to Ctrl. Interestingly, in E2, CHI had a more dominant effect on increasing the abundance of health promoting genera like <em>Catenisphaera</em>, <em>Butyricicoccus</em>, etc. and decreasing harmful genera like <em>Erysipelotrichaceae_UCG-002</em> and <em>Turicibacter</em>. In E2, on W3 several inflammatory target genes (CXCL10, IL18, TNFα) and inflammation signalling genes (MyD88, NFκB1) were downregulated in ileum of INU and CHI. In colon, both chicory and inulin, proved to be beneficial, as the inflammation signalling and inflammatory targets genes NFκB1, DEFβ4A, TLR2 and IFNα were significantly downregulated. Therefore, crude chicory flour might also be a promising cost-effective alternative supplement to improve gut health in weaned piglets.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106578"},"PeriodicalIF":3.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scallop ceramide 2-aminoethylphosphonate is more effective than egg yolk sphingomyelin in improving cholesterol metabolism in obese/type II diabetic KK-Ay mice","authors":"Koki Sugimoto ,&nbsp;Ayano Kosaka ,&nbsp;Ryota Hosomi ,&nbsp;Saki Itonori ,&nbsp;Munehiro Yoshida ,&nbsp;Kenji Fukunaga","doi":"10.1016/j.jff.2024.106569","DOIUrl":"10.1016/j.jff.2024.106569","url":null,"abstract":"<div><div>We discovered that the phospholipids present in the internal organs of scallops (<em>Patinopecten yessoensis</em>), which are primarily composed of glycerophospholipids and ceramide 2-aminoethylphosphonate (CAEP), reduced the serum and liver cholesterol contents in mice. This study evaluated the effects of scallop CAEP on lipid metabolism by comparing it to sphingomyelin. The study involved feeding four-week-old male KK-<em>A^y</em> mice either a high-fat diet or a high-fat diet supplemented with 0.5 wt% each of CAEP and sphingomyelin for 35 days. We found that CAEP intake lowered the serum triacylglycerol content, partly via a reduction in the mRNA expression levels of fatty acid synthesis-related genes in the liver. Furthermore, the CAEP diet reduced the serum and liver cholesterol contents. This effect was partially mediated by the increase in fecal total sterol excretion. Thus, this study indicates CAEP will be employed as a health-promoting component to lower the body’s triacylglycerol and cholesterol contents.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106569"},"PeriodicalIF":3.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward personalized cancer management: Role of precision nutrition–diet interventions","authors":"Hongfei Guo ,&nbsp;Yvchen Liu ,&nbsp;Tian Wan ,&nbsp;Da Song ,&nbsp;Chella Perumal Palanisamy ,&nbsp;Jingzhang Geng ,&nbsp;Jinjin Pei ,&nbsp;Sevilay Özmen ,&nbsp;A.M. Abd El-Aty","doi":"10.1016/j.jff.2024.106584","DOIUrl":"10.1016/j.jff.2024.106584","url":null,"abstract":"<div><div>Cancer is a major global health challenge, and current treatment modalities, such as surgery, chemotherapy, radiation therapy, immunotherapy, and targeted therapies, are often associated with various adverse effects. Dietary strategies have emerged as potential avenues for attenuating cancer growth, progression, and metastasis in numerous solid tumor models. Early clinical studies suggest that dietary interventions hold promise for improving cancer outcomes. This review examines potential dietary interventions that target specific aspects of tumor metabolism. It first examines research on carbohydrates, proteins, lipids, and other interventions, such as vitamins and nutritional supplements, in the context of cancer treatment or management. In addition, it outlines recent developments in cancer interventions involving different dietary patterns and specific dietary restrictions on the basis of preclinical investigations and clinical trials. Finally, this review provides insights into the future prospects of dietary interventions in cancer management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106584"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}