Journal of Functional Foods最新文献_第3页

Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology 副干酪乳杆菌发酵枸杞汁通过抑制炎症和调节肠道微生态改善小鼠便秘

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-24 DOI: 10.1016/j.jff.2025.106841

Xiaoyu He , Yu Zhang , Haitian Fang , Ni Ma , Xueni Yan , Huabing Yang , Lu Cao , Lu Xu , Haiming Hu , Hongtao Liu

{"title":"Lactobacillus paracasei fermented goji juice improves constipation in mice through inhibiting inflammation and regulating intestinal microecology","authors":"Xiaoyu He , Yu Zhang , Haitian Fang , Ni Ma , Xueni Yan , Huabing Yang , Lu Cao , Lu Xu , Haiming Hu , Hongtao Liu","doi":"10.1016/j.jff.2025.106841","DOIUrl":"10.1016/j.jff.2025.106841","url":null,"abstract":"<div><div>This study investigated the effects of <em>Lactobacillus paracasei</em> (<em>L. paracasei</em>)-fermented Goji juice supernatant (FGS) on constipation. GC–MS data showed that the critical metabolites of FGS were nicotinamide, squalene, L-proline, melatonin, and sarcosine. FGS intervention significantly promoted intestinal peristalsis. Meanwhile, FGS ameliorated intestinal inflammation and mucosal barrier damage by inhibiting the expressions of pro-inflammatory factors (TNF-α, IL-1β, COX-2), promoting the expressions of Mucin 1, Mucin 3, ZO-1, AQP4, and ENac-γ. In addition, FGS treatment modulated gut microbiota composition, reduced the abundance of harmful bacteria (<em>Faecalibaculum</em>, <em>Bacteroides</em>, <em>Alloprevotella</em> and <em>Alistipes</em>), induced a bloom of probiotics, including <em>Marvinbryantia</em>, <em>Eubacterium</em>_<em>xylanophilum</em>_group, <em>Colidextribacter</em>, and <em>Candidatus</em>_<em>Soleaferrea</em>. Conclusively, this study demonstrated that FGS significantly reduced inflammatory response, prevented intestinal barrier damage, and modulated microbiota dysbiosis to improve constipation. Compared to unfermented Goji juice (UFGJ), FGS has shown a more effective anti-constipation effect, indicating that FGS could relieve constipation as a dietary therapeutic.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106841"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure 印尼无刺蜂Geniotrigona胸腔蜂胶提取物在改善肥胖和调节炎症和自噬过程中的作用后，手掌为基础的高脂肪饮食暴露

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-24 DOI: 10.1016/j.jff.2025.106831

Andreas Christoper , Elvine Gunawan , Herry Herman , Rizky Abdulah , Felix Zulhendri , Milena Popova , Boryana Trusheva , Vassya Bankova , Ronny Lesmana

{"title":"The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure","authors":"Andreas Christoper , Elvine Gunawan , Herry Herman , Rizky Abdulah , Felix Zulhendri , Milena Popova , Boryana Trusheva , Vassya Bankova , Ronny Lesmana","doi":"10.1016/j.jff.2025.106831","DOIUrl":"10.1016/j.jff.2025.106831","url":null,"abstract":"<div><div>Obesity is a global health problem that can lead to organ damage, particularly affecting brain function. This study aims to investigate the role of Indonesian propolis extract in mitigating neuroinflammation following a prolonged high-fat diet. The experiment used four groups of Wistar rats: Normal chow diet (NCD), Normal chow diet with Propolis (NCP), High-fat diet (HFD), and High-fat diet with Propolis (HFP). The experiment was conducted for 21 weeks of a high-fat diet, with propolis administrated during the last nine weeks. The propolis extract used in the study predominantly contained triterpenoids, including cycloartenol, amyrenone, and mangiferolic acid. The rats were sacrificed with the prefrontal cortex collected at the end of the study. Cortical inflammatory cytokines IL-1β, IL-6, and TNF-α were analyzed using Multiplex Immunoassay, whereas autophagy proteins LC3 and ATG5 were examined using Western Blot. The mean body weight of the HFP was lower than that of the HFD. The HFP revealed lower IL-1β, TNF-α, and LC3-II levels, but greater ATG5 and IL-6 levels than the HFD. These findings suggest that propolis may help preserve neurological function by reducing inflammation after a long-term high-fat diet through weight reduction and restoration of autophagy function.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106831"},"PeriodicalIF":3.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect and pathways of the selenylation-modified nondigestive longan (Dimocarpus longan Lour.) polysaccharides in IEC-6 cells with indomethacin injury 硒化修饰的非消化性龙眼多糖对吲哚美辛损伤ec -6细胞的保护作用及其途径

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-23 DOI: 10.1016/j.jff.2025.106833

Ya-Hui Yu , Xin-Huai Zhao

{"title":"Protective effect and pathways of the selenylation-modified nondigestive longan (Dimocarpus longan Lour.) polysaccharides in IEC-6 cells with indomethacin injury","authors":"Ya-Hui Yu , Xin-Huai Zhao","doi":"10.1016/j.jff.2025.106833","DOIUrl":"10.1016/j.jff.2025.106833","url":null,"abstract":"<div><div>Covalent combination of Se with natural polysaccharides provides bioactive organic Se strategically. Thus, nondigestive longan (<em>Dimocarpus longan</em> Lour.) polysaccharides (LP) were selenylation-modified to obtain SeLP1 and SeLP2 with Se contents of 1.46 and 4.79 g/kg. SeLP1, SeLP2, and LP (as control) were assessed for their activities in IEC-6 cells exposed to indomethacin. Compared with LP, SeLP1 and especially SeLP2 were more active in ameliorating the indomethacin-induced cytotoxicity and oxidative stress, <em>via</em> increasing cell viability, decreasing lactate dehydrogenase release and ROS production, and reducing mitochondrial membrane potential loss. Both SeLP1 and SeLP2 were more potent than LP in alleviating the induced barrier disruption, causing rescued barrier integrity and up-regulated three tight junction-related genes and proteins. Additionally, both SeLP1 and SeLP2 ameliorated barrier dysfunction by suppressing MAPK- and mitochondrial apoptosis-mediated signaling pathways. Collectively, this selenylation and higher selenylation extent endowed SeLP2 with higher activity in ameliorating the indomethacin-caused cytotoxicity and barrier disruption.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106833"},"PeriodicalIF":3.8,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoprotective effects of the fermented milk by Streptococcus thermophilus CGMCC 24468 against ROS damage in HaCaT cells 嗜热链球菌发酵乳CGMCC 24468对HaCaT细胞ROS损伤的细胞保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-22 DOI: 10.1016/j.jff.2025.106829

Tingting Zhang , Yan Li , Chunying Yuan , Xiaoce Zhu , Mingyu Wang , Suzhen Yang , Jian Kong

引用次数: 0

Sweet potato resistant starch type 3 improves lipid metabolism by modulating intestinal microbiota in high-fat diet-fed mice 甘薯抗性淀粉3型通过调节肠道微生物群改善高脂饮食小鼠的脂质代谢

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-22 DOI: 10.1016/j.jff.2025.106837

Xiaofan Pan , Nan Zhang , Shijuan Hao , Jiawei Pei , Yiling Tian , Runfang Guo

{"title":"Sweet potato resistant starch type 3 improves lipid metabolism by modulating intestinal microbiota in high-fat diet-fed mice","authors":"Xiaofan Pan , Nan Zhang , Shijuan Hao , Jiawei Pei , Yiling Tian , Runfang Guo","doi":"10.1016/j.jff.2025.106837","DOIUrl":"10.1016/j.jff.2025.106837","url":null,"abstract":"<div><div>Type 3 resistant starch (RS3) has been recognized for its potential to ameliorate obesity by modulating the intestinal microbiota. Our previous study confirmed that sweet potato RS3 (SP-RS3), which is readily obtainable from daily life, exhibited excellent resistance to gastrointestinal digestion. This study aimed to further investigate the effects of SP-RS3 on high-fat diet-induced obesity in mice. Results showed that SP-RS3 significantly reduced body weight gain and fat accumulation, reduced blood lipid level, alleviated oxidative stress, and improved liver function. Furthermore, SP-RS3 modulated the abundance and composition of the intestinal microbiota, decreasing the Firmicutes/Bacteroidetes ratio, and increasing the relative abundance of <em>Bacteroides</em>, <em>Ruminococcus</em>, <em>Akkermansia</em>, <em>Bifidobacterium</em>, while decreasing the relative abundance of <em>Desulfovibrio</em> and <em>Helicobacter</em>. In summary, SP-RS3 shows promising potential in regulating lipid metabolism by modulating intestinal microbiota</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106837"},"PeriodicalIF":3.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characteristics of oligosaccharides obtained from Undaria pinnatifida polysaccharides and their alleviation of colitis by modulating macrophage polarization and gut microbiota 裙带菜多糖低聚糖的结构特征及其通过调节巨噬细胞极化和肠道菌群减轻结肠炎的作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-22 DOI: 10.1016/j.jff.2025.106835

Biao Yu , Baojun Xu , Karsoon Tan , Saiyi Zhong , Kit-Leong Cheong

{"title":"Structural characteristics of oligosaccharides obtained from Undaria pinnatifida polysaccharides and their alleviation of colitis by modulating macrophage polarization and gut microbiota","authors":"Biao Yu , Baojun Xu , Karsoon Tan , Saiyi Zhong , Kit-Leong Cheong","doi":"10.1016/j.jff.2025.106835","DOIUrl":"10.1016/j.jff.2025.106835","url":null,"abstract":"<div><div><em>Undaria pinnatifida</em> oligosaccharides (UPO) are recognized for their multifaceted bioactive properties. Nevertheless, further investigation is required to establish the protective effects of UPO in mitigating UC. In this study, the structural characteristics of UPO were elucidated as 1,4-linked α-L-fucopyranose units with minor 1,2-linked β-<span>d</span>-galactopyranose units through NMR spectroscopy. UPO treatment improved the structural integrity of the intestinal barrier in DSS-induced colitis mice. Additionally, UPO administration induced the polarization of macrophages towards the anti-inflammatory M2 phenotype, evidenced by the downregulation of M1 macrophage marker (CD68) and upregulation of M2 macrophage marker (CD163). UPO treatment, significant alterations in the composition and diversity of bacterial and fungal microbiota were observed compared to colitis mice. UPO boosted the concentrations of short-chain fatty acids in fecal samples. These findings indicate that UPO could alleviate DSS-induced colitis in mice, potentially offering insights into its application as a novel therapeutic option for colitis treatment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106835"},"PeriodicalIF":3.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of Antroquinonol B, an active ingredient of Antrodia camphorata, on acute liver injury 樟芝活性成分 Antroquinonol B 对急性肝损伤的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-22 DOI: 10.1016/j.jff.2025.106836

Hui Li , Hongyun Zhang , Zhaochu Wang , Fatao He , Le Chu , Guangpeng Liu , Lianzhong Ai , Yongjun Xia

{"title":"Protective effect of Antroquinonol B, an active ingredient of Antrodia camphorata, on acute liver injury","authors":"Hui Li , Hongyun Zhang , Zhaochu Wang , Fatao He , Le Chu , Guangpeng Liu , Lianzhong Ai , Yongjun Xia","doi":"10.1016/j.jff.2025.106836","DOIUrl":"10.1016/j.jff.2025.106836","url":null,"abstract":"<div><div><em>Antrodia camphorata</em>, a well-known and highly valued edible mushroom, with a concentration of triterpenoids, active polysaccharides, succinic acid, maleic acid derivatives, antroquinonol and its derivatives. Liver disease has emerged as a major global health concern. In this study, we obtained ethanol extracts and isolating three active ingredients. We then employed a mouse model to assess these ingredients and identify the most effective one. Our findings indicated that active ingredients effectively mitigated CCl<sub>4</sub>-induced liver injury, as evidenced by reduced serum levels of ALT, AST, and AKP in mice. Moreover, it exhibited potent antioxidant activity marked by decreased MDA levels and increased GSH and T-AOC concentrations. Animal experiments and L-O2 cell assays revealed that Antroquinonol B demonstrated strong antioxidant and anti-apoptotic activities. Through analysis of MAPKs pathway-related protein expression, we found that Antroquinonol B suppressed protein phosphorylation of p38 and JNK. These findings suggestted potential applications for <em>Antrodia camphorata</em> in hepatoprotection</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106836"},"PeriodicalIF":3.8,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143855174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lycopus lucidus Turcz. extract ameliorates CCl4-induced liver damage by MAPK/Nrf2 signaling pathways and gut microbiota in mice 绿番茄。提取物可通过MAPK/Nrf2信号通路和肠道菌群改善ccl4诱导的小鼠肝损伤

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-21 DOI: 10.1016/j.jff.2025.106834

Yuehong Lu , Yue Hong , Tianze Sun , Fengjuan Li , Yuyao Li , Bo Liu , Wenjing Wang , Chunyan Gao

{"title":"Lycopus lucidus Turcz. extract ameliorates CCl4-induced liver damage by MAPK/Nrf2 signaling pathways and gut microbiota in mice","authors":"Yuehong Lu , Yue Hong , Tianze Sun , Fengjuan Li , Yuyao Li , Bo Liu , Wenjing Wang , Chunyan Gao","doi":"10.1016/j.jff.2025.106834","DOIUrl":"10.1016/j.jff.2025.106834","url":null,"abstract":"<div><div>This work explored the protection of free phenolic extract from <em>Lycopus lucidus</em> root (FPLR) against liver damage caused by CCl<sub>4</sub> and its underlying mechanisms in mice. Mice were separated into the normal group (control), model group (CCl<sub>4</sub>), and FPLR group (FPLR+ CCl<sub>4</sub>). FPLR reduced liver or spleen index, improved liver function, and alleviated histopathological lesions, oxidative stress, and inflammation. Meanwhile, FPLR inhibited protein phosphorylation in the mitogen-activated protein kinases (MAPK) pathway, up-regulated gene and protein expression in the Nuclear Factor erythroid 2-Related Factor 2 (Nrf2) pathway, and down-regulated kelch-like ECH-associated protein 1 (Keap1) expression. Furthermore, FPLR increased the number of beneficial gut microbes, including <em>Bacteroidales_S24_7_group</em>, <em>Lactobacillus,</em> and <em>Parabacteroides distasonis</em>, while lowering the <em>Firmicutes</em>/<em>Bacteroidetes</em> ratio and harmful ones, such as <em>Streptococcaceae</em>, <em>Ruminococcaceae_UCG-014, and Oscillibacter</em> (all <em>p</em> < 0.05). Correlation analysis suggested nine bacteria, including <em>Lactobacillus</em>, <em>Staphylococcus,</em> and <em>Parabacteroides_distasonis</em>, played an important role in preventing liver damage, activating the Nrf2 pathway and inhibiting Keap1. In conclusion, FPLR successfully mitigated CCl<sub>4</sub>-induced liver damage by modulating the MAPK/Nrf2 pathways and gut microbiota.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106834"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects and potential mechanisms of Pyracantha fortuneana fruit extract on chemotherapy-induced thrombocytopenia revealed by transcriptomic analysis 火棘果提取物对化疗性血小板减少的保护作用及其潜在机制的转录组学分析

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-21 DOI: 10.1016/j.jff.2025.106838

Hang Xu , Shuwen Lei , Jing Li , Daiwei Xianyu , Dong Li , Mengjie Lei , Zhiyong Lei , Xiaojuan Chen , Chunfang Zhao , Chunhua Fu , Longjiang Yu

{"title":"Protective effects and potential mechanisms of Pyracantha fortuneana fruit extract on chemotherapy-induced thrombocytopenia revealed by transcriptomic analysis","authors":"Hang Xu , Shuwen Lei , Jing Li , Daiwei Xianyu , Dong Li , Mengjie Lei , Zhiyong Lei , Xiaojuan Chen , Chunfang Zhao , Chunhua Fu , Longjiang Yu","doi":"10.1016/j.jff.2025.106838","DOIUrl":"10.1016/j.jff.2025.106838","url":null,"abstract":"<div><div><em>Pyracantha fortuneana</em> fruit is traditionally consumed as a dietary supplement in China known for its benefits in blood nourishment. Thrombocytopenia is often associated with blood deficiency. However, scientific studies on the platelet-enhancing activity of <em>P. fortuneana</em> fruit are lacking. This study investigates the protective effects of <em>P. fortuneana</em> fruit extract (PFE) against chemotherapy-induced thrombocytopenia (CIT) and elucidates molecular mechanisms underlying its platelet-enhancing effects. Results showed that PFE, particularly its ethyl acetate fraction (PFEEA), significantly increased platelet counts by 48.7 %, reduced bleeding and clotting times, and decreased bleeding volume. PFEEA also mitigated organ injuries and lowered serum alanine transaminase levels. Transcriptomic analysis revealed upregulation of genes enriched in the hematopoietic cell lineage pathway by PFEEA, along with normalization of hematopoiesis-related cytokine levels and thrombopoietin mRNA expression in the liver. This study establishes PFE's potential against CIT and provides insights into its mechanisms, supporting its application as a functional food.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106838"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights and synergistic effects of Qi-Fu-Qing-You formulation in combating Helicobacter pylori infection and maintaining gut microbial homeostasis 芪复清油方抗幽门螺杆菌感染和维持肠道微生物稳态的机理及协同作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-04-21 DOI: 10.1016/j.jff.2025.106824

Shuyi Sang , Chuqiu Zhang , Bingyun Lu , Yuanjing Zou , Chang Peng , Yuqian Lai , Meicun Yao , Ye Chen , Qingchang Chen

{"title":"Mechanistic insights and synergistic effects of Qi-Fu-Qing-You formulation in combating Helicobacter pylori infection and maintaining gut microbial homeostasis","authors":"Shuyi Sang , Chuqiu Zhang , Bingyun Lu , Yuanjing Zou , Chang Peng , Yuqian Lai , Meicun Yao , Ye Chen , Qingchang Chen","doi":"10.1016/j.jff.2025.106824","DOIUrl":"10.1016/j.jff.2025.106824","url":null,"abstract":"<div><div><em>Helicobacter pylori (H. pylori)</em> infection affects over half of the global population, leading to chronic gastritis, gastric ulcers and cancer. Traditional antibiotic therapies face challenges such as resistance and gut microbiota dysbiosis, necessitating alternative solutions. Qi-Fu-Qing-You (QFQY) formulation was developed using medicinal and edible plants. This study investigated its anti-<em>H. pylori</em> efficacy, active components, and mechanisms of action. Phytochemical analysis revealed bioactive compounds such as ellagic acid, gallic acid, and psoralen, which demonstrated significant antibacterial activity against both antibiotic-sensitive and -resistant <em>H. pylori</em> strains. Molecular dynamics simulations showed that these compounds bind to the allosteric site of penicillin-binding protein 1 A (PBP1A), enhancing antibiotic binding affinity and improving antibacterial efficacy. In vivo studies confirmed QFQY's ability to mitigate antibiotic-induced intestinal damage through anti-inflammatory and anti-apoptotic effects, maintaining gut microbiota balance. The results underscore QFQY's potential as a functional food for <em>H. pylori</em> management and as an adjunct to antibiotic therapies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106824"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0