Journal of Functional Foods最新文献_第3页

Maternal odd-chain fatty acid-rich algal oil supplementation during pregnancy improves litter characteristics of intrauterine growth restricted pregnant mice via regulating placental function 孕期补充富含奇链脂肪酸的母体海藻油，可通过调节胎盘功能改善宫内生长受限妊娠小鼠的胎仔特征

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-21 DOI: 10.1016/j.jff.2024.106586

Yi Li , Yujun Wu , Meng Liu , Dandan Han , Yanwei Xu , Bingxu Huang , Fang Cong , Mengmeng Li , Bo Cao , Cuiping Feng , Hongbiao Ding , Junjun Wang

{"title":"Maternal odd-chain fatty acid-rich algal oil supplementation during pregnancy improves litter characteristics of intrauterine growth restricted pregnant mice via regulating placental function","authors":"Yi Li , Yujun Wu , Meng Liu , Dandan Han , Yanwei Xu , Bingxu Huang , Fang Cong , Mengmeng Li , Bo Cao , Cuiping Feng , Hongbiao Ding , Junjun Wang","doi":"10.1016/j.jff.2024.106586","DOIUrl":"10.1016/j.jff.2024.106586","url":null,"abstract":"<div><div>Intrauterine growth restriction (IUGR) severely impairs fetal development and offspring health. Odd-chain fatty acid (OCFA) possess beneficial biological activities in regulating insulin resistance, inflammation and oxidative stress. However, the effects of OCFA on improving IUGR through regulating placental function and maternal health remain unclear. Herein, maternal OCFA-rich algal oil supplementation improved variable coefficient of fetal weight and fetal oxidative stress in low protein diet (LPD)-induced IUGR mice model. OCFA-rich algal oil also improved placental dysfunction, placental fatty acid metabolism disorder, maternal insulin resistance, oxidative stress and intestinal injury, suggesting an improved maternal health. OCFA-rich algal oil reshaped the intestinal microbiome of dams, decreasing <em>unclassified Bacteroidales</em> and <em>Parvibacter</em>, and increasing <em>Weissella</em>, which positively impacted insulin resistance and intestinal injury. Overall, OCFA-rich algal oil supplementation during pregnancy ameliorated oxidative stress, insulin resistance and intestinal injury in LPD-induced IUGR pregnant mice, improved placental functions and litter characteristics, and further enhanced fetal antioxidant capacity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106586"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonic-assisted extraction and the antioxidative mechanism of eggplant root polysaccharide 超声波辅助提取茄子根多糖及其抗氧化机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-21 DOI: 10.1016/j.jff.2024.106590

Shiyang Zhou , Gangliang Huang , Fengming Ren

{"title":"Ultrasonic-assisted extraction and the antioxidative mechanism of eggplant root polysaccharide","authors":"Shiyang Zhou , Gangliang Huang , Fengming Ren","doi":"10.1016/j.jff.2024.106590","DOIUrl":"10.1016/j.jff.2024.106590","url":null,"abstract":"<div><div>Polysaccharides from eggplant roots were extracted by ultrasonic-assisted water extraction, and purified polysaccharides were obtained by sevage deproteinization, dialysis and freeze drying. To study its <em>in vitro</em> antioxidant effect on RAW264.7 cells, <em>in vivo</em> antioxidant activity in mice model and protective effect of H<sub>2</sub>O<sub>2</sub>-induced oxidative stress damage in RAW264.7 cells, and to reveal its mechanism. The result showed that eggplant root polysaccharide was an acid heteropolysaccharide composed of Fuc (fucose), Rha (rhamnoose), Ara (arabinose), Galg (alactose), Glc (glucose), Xyl (xylose), Man (mannose), Gal-UA (galacturonic acid), and Gle-UA (glucuronic acid). The results of <em>in vitro</em> experiment showed that eggplant root polysaccharide had no obvious cytotoxic activity in the concentration range of 40–640 μg/mL. At the concentration of 320 μg/mL, it could significantly increase the secretion of CAT (catalase), SOD (superoxide dismutase), and GSH-Px (glutathione peroxidase) on RAW264.7 cells, while significantly decrease the secretion of MDA (malondialdehyde). It has obvious protective effect on RAW264.7 cells damaged by H<sub>2</sub>O<sub>2</sub>. <em>In vivo</em> experiment results showed that medium and high dose (320 and 640 μg/mL) of eggplant root polysaccharide can significant increase activities of SOD and GSH-Px in the serum and liver of mice, but significant reduce content of MDA, which plays a good role <em>in vivo</em> antioxidant. The preliminary mechanism results showed that the addition of eggplant root polysaccharide could increase protein content of Nrf2 (nuclear factor-related factor 2), HO-1 (heme oxygenase 1), and NQO1 (NADPH quinone oxidoreductase 1). It was preliminarily speculated that the antioxidant effect of eggplant root polysaccharide <em>in vivo</em> may be the result of Nrf2, HO-1, NQO1 protein or gene interaction.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106590"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating multi-level interactive network analysis and in vivo studies to explore the protective mechanism of Maillard products of skipjack trypsin hydrolysate in hyperuricemia 整合多层次交互式网络分析和体内研究，探索鲣鱼胰蛋白酶水解产物对高尿酸血症的保护机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-21 DOI: 10.1016/j.jff.2024.106593

Xueping Wang , Jiaxing Wang , Yurou Chu , Jipeng Sun , Ru Song , Bin Zhang

{"title":"Integrating multi-level interactive network analysis and in vivo studies to explore the protective mechanism of Maillard products of skipjack trypsin hydrolysate in hyperuricemia","authors":"Xueping Wang , Jiaxing Wang , Yurou Chu , Jipeng Sun , Ru Song , Bin Zhang","doi":"10.1016/j.jff.2024.106593","DOIUrl":"10.1016/j.jff.2024.106593","url":null,"abstract":"<div><div>This study used skipjack by-products to produce skipjack trypsin hydrolysate (STH), which was then processed through the Maillard reaction to create its Maillard product, STHMS3 (200–1000 Da). We evaluated STHMS3's protective effects against hyperuricemia-induced renal injury in mice. Utilizing in vivo experiments, network pharmacology, and molecular docking, we explored its protective mechanisms. STHMS3 significantly decreased serum uric acid, creatinine, blood urea nitrogen, and xanthine oxidase (XOD) levels, reduced oxidative stress, and enhanced antioxidant protein levels in kidneys. Network pharmacology analysis showed STHMS3's interaction with multiple targets and pathways, including apoptosis, NF-κB, and TNF signaling pathways, suggesting a multi-level interactive network mechanism. Molecular docking confirmed STHMS3's ability to directly inhibit XOD through hydrogen bond formation. This study highlights the therapeutic potential of food-derived peptides in managing hyperuricemia and protecting renal function.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106593"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota Pediococcus acidilactici XM-06 发酵的人参皂苷通过调节肠道屏障功能和肠道微生物群预防小鼠腹泻的作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-21 DOI: 10.1016/j.jff.2024.106594

Wen-Man Xu , Qi Liu , Si-Yao Fan , Zi-Xin Wang , Shi-Rui Lu , Jie Liu , Hong-Jie Piao , Wenxiu Ji , Wei-Wei Dong

{"title":"Effect of ginsenoside fermented by Pediococcus acidilactici XM-06 on preventing diarrhea in mice via regulating intestinal barrier function and gut microbiota","authors":"Wen-Man Xu , Qi Liu , Si-Yao Fan , Zi-Xin Wang , Shi-Rui Lu , Jie Liu , Hong-Jie Piao , Wenxiu Ji , Wei-Wei Dong","doi":"10.1016/j.jff.2024.106594","DOIUrl":"10.1016/j.jff.2024.106594","url":null,"abstract":"<div><div>Ginsenosides has been extensively used in clinical settings to treat various inflammatory diseases. At present, the anti-inflammatory effect of ginsenosides is mainly focused on monomeric ginsenosides, while the total saponins of ginseng and their synergistic effect with probiotic fermentation products are rarely studied. This study aimed to investigate the mitigative effects of fermented ginsenosides with <em>Pediococcus acidilactici</em> on Enterotoxigenic <em>Escherichia coli</em> diarrhea in mice. <em>P. acidilactici</em> XM-06 and ginsenoside fermentation products demonstrated significant pre-protection against ETEC-induced diarrhea by mitigating inflammation, inhibited the ERK and upregulated the Z0–1, 0ccludin and Claudin-1 levels, and reducing oxidative stress. These products not only repaired intestinal mucosal damage caused by ETEC-induced diarrhea in mice but also positively influenced gut microbiota dysbiosis by increasing the abundance of <em>Lactobacillus</em> and <em>Bacteroides</em> while decreasing the abundance of <em>Enterobacter</em>, potentially providing a new natural product for the prevention of ETEC-associated diarrheal diseases in humans.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106594"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Taohong Siwu Decoction improves cerebral ischemia–reperfusion injury through SIRT1/FOXO1 signaling pathway 桃红四物汤通过 SIRT1/FOXO1 信号通路改善脑缺血再灌注损伤

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-21 DOI: 10.1016/j.jff.2024.106574

Yumeng Li , Chao Yu , Sujun Xue , Lijuan Zhang , Jingjing Li , Shuangping Li , Qingping Ye , Xianchun Duan , Daiyin Peng

{"title":"Taohong Siwu Decoction improves cerebral ischemia–reperfusion injury through SIRT1/FOXO1 signaling pathway","authors":"Yumeng Li , Chao Yu , Sujun Xue , Lijuan Zhang , Jingjing Li , Shuangping Li , Qingping Ye , Xianchun Duan , Daiyin Peng","doi":"10.1016/j.jff.2024.106574","DOIUrl":"10.1016/j.jff.2024.106574","url":null,"abstract":"<div><h3>Background</h3><div>Ischemic stroke (IS), generally referred to as cerebral infarction (CI), is a high-risk stroke. After CI, blood vessels need to be reopened, and cerebral ischemia–reperfusion injury (CIRI) is prone to occur during this period. Taohong Siwu Decoction (THSWD) is a traditional Chinese herbal formula that has been used to activate blood circulation and remove blood stasis. It has been confirmed that THSWD can improve CIRI caused by ischemic stroke, but its specific mechanism is not clear.</div></div><div><h3>Methods</h3><div>We observed the protective effect of THSWD on rats that had undergone middle cerebral artery occlusion and reperfusin (MCAO/R) and PC12 cells after oxygen glucose deprivation/re-oxygenation (OGD/R) injury based on the silent information regulator 1/forkhead box protein O1 (SIRT1/FOXO1) signaling pathway. We explored the role of the SIRT1/FOXO1 signaling pathway on the use of THSWD for ischemic stroke (IS) and its mechanism from the perspectives of oxidative stress, autophagy and apoptosis. Experimental tools included neurological deficit assessment, staining, Tunel assay, transmission electron microscopy, flow cytometry, immunofluorescence, immunohistochemistry, and Western blot.</div></div><div><h3>Results</h3><div>We detected activation of the SIRT1/FOXO1 signaling pathway after THSWD administration on MCAO/R rats and PC12 cells after OGD/R. THSWD attenuated oxidative stress, enhanced autophagy, and inhibited apoptosis.</div></div><div><h3>Conclusion</h3><div>THSWD can improve CIRI by modulating the SIRT1/FOXO1 signaling pathway.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106574"},"PeriodicalIF":3.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugated linoleic acid ameliorates necrotizing enterocolitis by suppressing inflammatory responses and maintaining intestinal barrier integrity via the PPARγ/NFκB signaling pathway 共轭亚油酸通过 PPARγ/NFκB 信号通路抑制炎症反应并维持肠屏障完整性，从而改善坏死性小肠结肠炎的病情

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-20 DOI: 10.1016/j.jff.2024.106581

Chengyao Jiang , Fan Zhang , Min Zhang , Xiangyun Yan, Yanjie Chen, Qinlei Yu, Wenjuan Chen, Xiaohui Chen, Shushu Li, Shuping Han

{"title":"Conjugated linoleic acid ameliorates necrotizing enterocolitis by suppressing inflammatory responses and maintaining intestinal barrier integrity via the PPARγ/NFκB signaling pathway","authors":"Chengyao Jiang , Fan Zhang , Min Zhang , Xiangyun Yan, Yanjie Chen, Qinlei Yu, Wenjuan Chen, Xiaohui Chen, Shushu Li, Shuping Han","doi":"10.1016/j.jff.2024.106581","DOIUrl":"10.1016/j.jff.2024.106581","url":null,"abstract":"<div><div>Necrotizing enterocolitis (NEC) is a severe inflammatory gastrointestinal disorder affecting preterm infants. Through fecal metabolomics, we found linoleic acid compounds (LAs) reduced in NEC and negatively correlated with C-reactive protein and NEC Bell stage. Conjugated linoleic acid (CLA) is a special kind of LAs with multiple functions. This study aims to investigate the role and mechanism of CLA in <em>vivo</em> and <em>vitro</em>. Experimental results in neonatal rats demonstrated that CLA significantly reduced mortality, weight loss, improved pathological scores, relieved inflammation and preserved intestinal cell homeostasis. In <em>vitro</em>, CLA promoted cell proliferation and reduced cell injury. RNA-sequencing analysis indicated that PPAR signaling pathway might be critical. Experiments showed that CLA facilitated PPARγ/NFκB signaling pathway by upregulating PPARγ expression, inactivating phosphorylated NFκB, and preventing translocation of NFκB P65. This study underscores the therapeutic potential of CLA and provides new insight and direction for developing NEC interventions.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106581"},"PeriodicalIF":3.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biologically active peptides from soy: Updates on antihypertensive action and gut microbiota modulation 大豆中的生物活性肽：抗高血压作用和肠道微生物群调节的最新进展

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-20 DOI: 10.1016/j.jff.2024.106592

Chunhong Liu , Chaoling Wen , Opeyemi Joshua Olatunji , Itthanan Suttikhana , Tolulope Joshua Ashaolu

引用次数: 0

Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo 辣椒素水提取物的综合评价：评估其在体外和体内对肠道屏障完整性和炎症的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-20 DOI: 10.1016/j.jff.2024.106563

Yu Rim Kim, Soo-yeon Park, Ji Yeon Kim

{"title":"Comprehensive evaluation of Capsosiphon fulvescens water extract: Assessing its effects on intestinal barrier integrity and inflammation in vitro and in vivo","authors":"Yu Rim Kim, Soo-yeon Park, Ji Yeon Kim","doi":"10.1016/j.jff.2024.106563","DOIUrl":"10.1016/j.jff.2024.106563","url":null,"abstract":"<div><div><em>Capsosiphon fulvescens</em> has potential benefits for functionality. However, research on its impact on gut health is limited. In this study, the therapeutic efficacy of <em>Capsosiphon fulvescens</em> water extract (CFW) was investigated, with its intestinal health benefits confirmed in Caco-2 cell and mouse models. In the animal study, 32 male C57BL/6 mice were divided into control, DSS, and CFW treatment groups and treated for 28 days, with DSS given ad libitum in 7 days. Significant improvements in various biomarkers related to intestinal barrier function, including increased transepithelial electrical resistance values and reduced permeability, were observed <em>in vitro</em> model. Moreover, the administration of CFW was associated with improved histological scores and improved levels of TJ proteins and cytokines. The therapeutic efficacy of CFW is believed to be associated with the bioactive compounds found in the extract. The findings here highlight the promising therapeutic potential of CFW for managing inflammatory bowel disease.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106563"},"PeriodicalIF":3.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirulina and chlorella derived hard candies as functional food 螺旋藻和小球藻衍生硬糖作为功能性食品

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-20 DOI: 10.1016/j.jff.2024.106565

Shafia Maryam , Mecit Halil Oztop , Sarper Doğdu , Mehmet Ali Marangoz , Zeshan Zeshan , M. Qasim Hayat , Ramish Riaz , Muhammad Waqas Alam Chattha , Hussnain Ahmed Janjua

{"title":"Spirulina and chlorella derived hard candies as functional food","authors":"Shafia Maryam , Mecit Halil Oztop , Sarper Doğdu , Mehmet Ali Marangoz , Zeshan Zeshan , M. Qasim Hayat , Ramish Riaz , Muhammad Waqas Alam Chattha , Hussnain Ahmed Janjua","doi":"10.1016/j.jff.2024.106565","DOIUrl":"10.1016/j.jff.2024.106565","url":null,"abstract":"<div><div>Hard candies with spirulina (<em>Arthrospira platensis</em>) and chlorella (<em>Chlorella vulgaris</em>) biomass were prepared. Their characterization include pH, moisture, hardness, color, total soluble solids, antioxidant, phenols, and flavonoid content. Safety tests were conducted on rats to examine protective effects of these candies against arsenate poisoning. Algal hard candies were slightly acidic, had low moisture content, and achieved optimal hardness. These candies contain 0.4 GAE mg/g phenols and 0.5 CAE mg/g flavonoids. Upon in-vivo analysis, algae candies increased acetyl cholinesterase, malondialdehyde, catalase, superoxide dismutase, and glutathione concentration in blood serum. Histopathology analysis revealed significant restoration in the liver, kidneys, and brain of Wistar rats treated with algal candies following arsenate poisoning. The phenolic and flavonoid content along with activation of antioxidative enzymes reveals radical scavenging activity of hard candies. Spirulina and chlorella candies may boost immune system, improving gut health, and enhancing antioxidant defense mechanisms and can be used as functional food.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106565"},"PeriodicalIF":3.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effects of postbiotics and live-probiotics containing Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 in patients with previous colorectal cancer: A randomized controlled trial 含有副乳酸杆菌 SD1 和鼠李糖乳杆菌 SD11 的后益生菌和活益生菌对曾患结直肠癌患者的效果比较：随机对照试验

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-19 DOI: 10.1016/j.jff.2024.106576

Worrawit Wanitsuwan , Nuntiya Pahumunto , Komwit Surachat , Suchera Thananimit , Monwadee Wonglapsuwan , Supparerk Laohawiriyakamol , Rawee Teanpaisan

{"title":"Comparison of the effects of postbiotics and live-probiotics containing Lacticaseibacillus paracasei SD1 and Lacticaseibacillus rhamnosus SD11 in patients with previous colorectal cancer: A randomized controlled trial","authors":"Worrawit Wanitsuwan , Nuntiya Pahumunto , Komwit Surachat , Suchera Thananimit , Monwadee Wonglapsuwan , Supparerk Laohawiriyakamol , Rawee Teanpaisan","doi":"10.1016/j.jff.2024.106576","DOIUrl":"10.1016/j.jff.2024.106576","url":null,"abstract":"<div><div>Evidence suggests that probiotics can be used as functional food to improve colorectal cancer (CRC) conditions. Postbiotics can provide the same benefits as the live form. The present study aimed to compare the effects of postbiotics and live probiotics containing <em>Lacticaseibacillus paracasei</em> SD1 and <em>Lacticaseibacillus rhamnosus</em> SD11 in patients with previous colorectal cancer. Results revealed that pro-inflammatory cytokines levels (IL-1β, TNF-α, IL-6, IL-8, and IL-17A) significantly reduced in patients who received postbiotics and live-strains compared to at the beginning of the study. Butyrate and anti-inflammatory cytokines levels significantly increased in patients who received the postbiotics and live-strains. Gut microbiota and butyrate producers increased while the pathogen <em>Fusobacterium</em> decreased among patients taking the postbiotics and live-strains. In conclusion, both forms of <em>L. paracasei</em> SD1 and <em>L. rhamnosus</em> SD11 could deliver benefits for improvement of CRC conditions, which further expanded the application of the postbiotics from this clinical trial.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106576"},"PeriodicalIF":3.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0