Journal of Functional Foods最新文献_第4页

Beetroot boost: Unlocking the power of Beta Vulgaris for peak athletic performance 甜菜根提升：解锁Beta Vulgaris的巅峰运动表现的力量

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jff.2026.107196

Jannat Bibi , Yao Lei , Muhammad Zia Ahmad , Katarzyna Kotwica-Mojzych , Mariola Głowacka , Mariusz Mojzych

{"title":"Beetroot boost: Unlocking the power of Beta Vulgaris for peak athletic performance","authors":"Jannat Bibi , Yao Lei , Muhammad Zia Ahmad , Katarzyna Kotwica-Mojzych , Mariola Głowacka , Mariusz Mojzych","doi":"10.1016/j.jff.2026.107196","DOIUrl":"10.1016/j.jff.2026.107196","url":null,"abstract":"<div><div>Beetroot (<em>Beta Vulgaris</em>) has garnered significant attention as a natural dietary supplement for enhancing athletic performance and endurance. Rich in nitrates, beetroot is converted into nitric oxide upon ingestion, improving blood flow, lung function, and muscle contraction. Recent studies highlighted beetroot's role in boosting endurance, athletic performance, and overall physical fitness. In addition to nitrates, beetroot contains an array of phytochemicals such as carotenoids, ascorbic acid, flavonoids, phenolic acids, and betalains. These bioactive compounds possess antioxidant, anti-inflammatory, and blood-enhancing properties, offering benefits like improved oxygen delivery and muscle recovery. Betalains, in particular, have shown promise in preventing muscle injury and mitigating oxidative stress. Available studies suggest that consuming approximately 500 mL of beetroot juice 2 to 3 h before exercise may enhance endurance and oxygen efficiency. However, there is conflicting evidence in the literature regarding the optimal dosage and the long-term effects of beetroot supplementation in sports science This review explores the current scientific understanding of beetroot's nutritional benefits, its physiological mechanisms, its potential as a natural alternative to synthetic supplements, and future perspective. By emphasizing its affordability and natural origin, this paper encourages further research and the adoption of beetroot in sports nutrition to boost athletic performance.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107196"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moroccan culinary spices as complementary or alternative medicine for the management of hyperglycemia in patients with type 2 diabetes: a comprehensive review 摩洛哥烹饪香料作为2型糖尿病患者高血糖管理的补充或替代药物：全面回顾

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.jff.2026.107210

Sbahi Mohamed , Chernane Halima , Assmaa Choukri , Himri imane , Aayah Hammoumi

{"title":"Moroccan culinary spices as complementary or alternative medicine for the management of hyperglycemia in patients with type 2 diabetes: a comprehensive review","authors":"Sbahi Mohamed , Chernane Halima , Assmaa Choukri , Himri imane , Aayah Hammoumi","doi":"10.1016/j.jff.2026.107210","DOIUrl":"10.1016/j.jff.2026.107210","url":null,"abstract":"<div><div>Type 2 diabetes (T2D) is a chronic disease marked by high blood glucose due to β-cell dysfunction, leading to major metabolic and cardiovascular risks. It is expected to reach 783 million people by 2045. In Morocco, its prevalence rose from 10.6% in 2018 to 13.8% in 2021. Managing hyperglycemia involves both pharmaceutical and dietary adjustments, including diet and physical activity. Complementary approaches, such as herbal products, are increasingly used to help control hyperglycemia. Herein, we summarized the potential advantageous impacts of the most used herbs in Moroccan cuisine, such as coriander, saffron, ginger, cumin, and turmeric, on glycemia in T2D. The review focuses on the interactions between the main bioactive compounds of each spice and glycemic regulation in healthy individuals and patients with T2D, while highlighting the underlying mechanistic pathways involved. The available evidence suggests a potential contribution to glycemic control, although the strength of evidence varies among spices.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107210"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pinocembrin in Indian lychee honey destabilizes hepatic lncRNA NEAT1 by inhibiting ALKBH5-mediated m6A-demethylation in non-alcoholic fatty liver disease condition 在非酒精性脂肪肝疾病中，印度荔枝蜂蜜中的木偶素通过抑制alkbh5介导的m6a去甲基化来破坏肝脏lncRNA NEAT1的稳定

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jff.2026.107168

Chandrachur Ghosh , Varuna Arora , Jyoti Barman , Somsuvra Chatterjee , Saugata Hazra , Debabrata Sircar , Prabhat Kumar , Partha Roy

{"title":"Pinocembrin in Indian lychee honey destabilizes hepatic lncRNA NEAT1 by inhibiting ALKBH5-mediated m6A-demethylation in non-alcoholic fatty liver disease condition","authors":"Chandrachur Ghosh , Varuna Arora , Jyoti Barman , Somsuvra Chatterjee , Saugata Hazra , Debabrata Sircar , Prabhat Kumar , Partha Roy","doi":"10.1016/j.jff.2026.107168","DOIUrl":"10.1016/j.jff.2026.107168","url":null,"abstract":"<div><div>Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern linked to metabolic dysfunction. Long non-coding RNAs (lncRNAs) like NEAT1 play critical roles in NAFLD pathogenesis. This study investigates the therapeutic potential of Indian lychee honey (LyH) and pinocembrin, a major component of LyH, against NAFLD. Mechanistically, the data showed that pinocembrin destabilized NEAT1 by inhibiting the activity of ALKBH5, a m6A RNA demethylase. RNA immunoprecipitation and RNA stability assay with actinomycin D further confirmed that this inhibition decreased the m6A modification of NEAT1, leading to its degradation. Furthermore, the effects of pinocembrin and LyH treatment against NEAT1 stabilization and lipid accumulation were validated by using a pharmacological inhibitor of ALKBH5 (cpd 20 m). These findings demonstrate that pinocembrin, a predominant phytochemical present in LyH, reduces lncRNA NEAT1 expression, correlating with attenuated lipid accumulation. Future studies employing NEAT1 gain-of-function would better clarify the mechanistic causality for this effect. Overall, this study offers LyH as a promising therapeutic strategy for NAFLD management by targeting the ALKBH5/NEAT1 axis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107168"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leuconostoc mesenteroides strain ES222 and Limosilactobacillus fermentum strain EM612: A novel approach to Colon Cancer therapy in rat models 大肠杆菌ES222和发酵乳酸杆菌EM612：结肠癌治疗大鼠模型的新方法

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-16 DOI: 10.1016/j.jff.2026.107204

Eman Mohammed , A. Taha , H.M. Gebreel , H.A.E. Sayed

引用次数: 0

Preventive effect of paraprobiotic Enterococcus faecalis FK-23 on bisphenol A-induced sperm toxicity 副益生菌粪肠球菌FK-23对双酚a致精子毒性的预防作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-18 DOI: 10.1016/j.jff.2026.107205

Yukiko Minamiyama , Shigekazu Takemura , Kanako Nakagawa , Hiroshi Ichikawa , Takeaki Ishizawa , Toshikazu Yoshikawa

{"title":"Preventive effect of paraprobiotic Enterococcus faecalis FK-23 on bisphenol A-induced sperm toxicity","authors":"Yukiko Minamiyama , Shigekazu Takemura , Kanako Nakagawa , Hiroshi Ichikawa , Takeaki Ishizawa , Toshikazu Yoshikawa","doi":"10.1016/j.jff.2026.107205","DOIUrl":"10.1016/j.jff.2026.107205","url":null,"abstract":"<div><h3>Background</h3><div>Bisphenol A (BPA), a chemical commonly used in food containers, has been detected in human blood and atheromas. It induces oxidative stress and impairs reproductive function. Developing preventive strategies against its biological effects is therefore essential.</div></div><div><h3>Objective</h3><div>This study investigated the protective effects of <em>Enterococcus faecalis</em> FK-23 against BPA-induced sperm dysfunction through suppression of oxidative stress in a rat model.</div></div><div><h3>Methods</h3><div>Male Wistar rats were assigned to control, FK-23, BPA, and BPA + FK-23 groups (<em>n</em> = <del>3–</del>6/group). Sperm motility was analyzed using a computer-assisted system, while reactive oxygen species (ROS) generation was assessed by chemiluminescence. Oxidative stress markers, including 4-hydroxy-2-nonenal (HNE)-modified proteins, were detected by western blotting and identified by LC-MS/MS. Plasma radical-scavenging capacity was evaluated using electron spin resonance.</div></div><div><h3>Results</h3><div>No significant differences were observed in general health indicators such as body weight among the groups. BPA exposure decreased sperm motility and increased ROS production in a time-dependent manner. FK-23 supplementation significantly attenuated these effects, particularly after 2 weeks. FK-23 also suppressed BPA-induced accumulation of HNE-modified proteins, including mitochondrial proteins. Moreover, while BPA reduced plasma antioxidant capacity by about 50%, especially hydroxyl and methyl radical scavenging, FK-23 preserved these activities.</div></div><div><h3>Conclusion</h3><div>The paraprobiotic FK-23 ameliorated BPA-induced sperm dysfunction, by mitigating systemic oxidative stress. These findings indicate that FK-23 has potential as a protective dietary intervention against environmental toxicants that impair male fertility.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107205"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ziziphus jujuba polysaccharide degradation products exert neuroprotective and anti-aging effects via modulating gut microbiota and metabolomics in C. elegans 酸枣多糖降解产物通过调节秀丽隐杆线虫的肠道菌群和代谢组学发挥神经保护和抗衰老作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-19 DOI: 10.1016/j.jff.2026.107213

Chunling Zhou , Longyi Bian , Yintong Zhang , Xiaoyan Huang , Dongsheng Jia , Ju Zhang

{"title":"Ziziphus jujuba polysaccharide degradation products exert neuroprotective and anti-aging effects via modulating gut microbiota and metabolomics in C. elegans","authors":"Chunling Zhou , Longyi Bian , Yintong Zhang , Xiaoyan Huang , Dongsheng Jia , Ju Zhang","doi":"10.1016/j.jff.2026.107213","DOIUrl":"10.1016/j.jff.2026.107213","url":null,"abstract":"<div><div>This study investigates the neuroprotective and anti-aging effects of enzymatically degraded <em>Ziziphus jujuba</em> polysaccharides (dZPs) versus native ZPs in <em>C. elegans</em> model of Huntington's disease (HD). Results showed dZPs exhibited more significant neuroprotective and anti-aging effects compared to ZPs, including enhanced ASH neuronal survival rate, extended mean lifespan and reduced lipofuscin accumulation. Crucially, dZPs remodeled gut microbiota composition, increased beneficial short-chain fatty acid (SCFAs) -producing bacteria, improved energy metabolism, and restored neurotransmitter balance, which coordinately alleviated mitochondrial dysfunction, and enhanced oxidative stress resistance via DAF-16/FOXO pathway activation (<em>sod-3</em>, <em>hsp-16.2</em> upregulation). Our findings demonstrate that enzymatic degradation effectively unlocks the significant therapeutic potential of plant polysaccharides for age-related neurodegeneration, with the underlying mechanism likely mediated by the modulation of gut microbiota composition and metabolomic profiles.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107213"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147385560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol improves contractile dysfunction, cell viability and oxidative stress in adult rat cardiomyocytes exposed to norepinephrine via SOD/FOXO1 白藜芦醇通过SOD/FOXO1改善去甲肾上腺素暴露的成年大鼠心肌细胞的收缩功能障碍、细胞活力和氧化应激

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.jff.2026.107174

Pema Raj , Liping Yu , Huong Nguyen , Inna Rabinovich-Nikitin , Sijo Joseph Thandapilly , Jeffrey Wigle , Shelley Zieroth , Thomas Netticadan

{"title":"Resveratrol improves contractile dysfunction, cell viability and oxidative stress in adult rat cardiomyocytes exposed to norepinephrine via SOD/FOXO1","authors":"Pema Raj , Liping Yu , Huong Nguyen , Inna Rabinovich-Nikitin , Sijo Joseph Thandapilly , Jeffrey Wigle , Shelley Zieroth , Thomas Netticadan","doi":"10.1016/j.jff.2026.107174","DOIUrl":"10.1016/j.jff.2026.107174","url":null,"abstract":"<div><div>In heart failure, cardiac remodeling and dysfunction are driven by abnormalities of cardiomyocyte caused by excessive circulating norepinephrine (NE). This study examined resveratrol's effect on NE-exposed adult rat cardiomyocytes. NE-induced morphological changes in cardiomyocytes, that reduce viability and contractile dysfunction, an increase in the levels of an oxidative stress and decrease in the activity of the antioxidant enzyme, superoxide dismutase (SOD). Resveratrol blocked NE-induced anomalies, improving cell viability and contractile function. Our study also revealed that resveratrol-mediated cardiomyocyte protection was lost when antioxidant enzyme activity of SOD was pharmacologically blocked. In addition, the pharmacological blockade of transcription factor forkhead box protein O1 (FOXO1) resulted in the negation of resveratrol-facilitated beneficial effects. Resveratrol also reduced the cardiac fibroblast viability without affecting cell death. In conclusion, resveratrol protects adult rat cardiomyocytes from NE-induced abnormalities including oxidative stress partly via SOD/FOXO1.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107174"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stachyose alleviates coronary heart disease by regulating apoptosis pathways: Insights from network pharmacology, transcriptomics, and experimental validation 水苏糖通过调节细胞凋亡途径缓解冠心病：来自网络药理学、转录组学和实验验证的见解

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.jff.2026.107182

Tingting Tang , Liyuan Yang , Chao Wang , Haiyan Lan , Xia Tao , Tao Pang , Feng Zhang , Wansheng Chen

{"title":"Stachyose alleviates coronary heart disease by regulating apoptosis pathways: Insights from network pharmacology, transcriptomics, and experimental validation","authors":"Tingting Tang , Liyuan Yang , Chao Wang , Haiyan Lan , Xia Tao , Tao Pang , Feng Zhang , Wansheng Chen","doi":"10.1016/j.jff.2026.107182","DOIUrl":"10.1016/j.jff.2026.107182","url":null,"abstract":"<div><div>Coronary heart disease (CHD) is a significant cardiovascular condition characterized by a complex pathological process involving increased oxidative stress and cardiomyocyte apoptosis. Stachyose, a naturally occurring functional food additive, has the potential to provide therapeutic benefits against this pathological condition. Our study aimed to explore the underlying mechanisms by which stachyose exerts its protective effects on CHD by employing network pharmacology and transcriptomics, with validation both in vivo and in vitro. The results demonstrated that stachyose reduced hemorheological abnormalities and blood coagulation, modulated platelet activation in CHD rats, contributed to ameliorating myocardial injury, and decreased myocardial apoptosis. Notably, stachyose alleviated oxidative stress -induced injury and apoptosis in DOX-treated H9c2 cells. Integrated network pharmacology and transcriptomic analyses revealed that stachyose treated CHD by modulating the P53 and FOXO1 signaling pathways and reducing the expression of apoptosis-related proteins. Furthermore, the involvement of these pathways was confirmed using both a P53 activator and inhibitor. Our study initially showed that stachyose inhibits cardiomyocyte apoptosis by regulating the P53 and FOXO1 signaling pathways, suggesting that could serve as a potential therapeutic option for CHD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107182"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of the human gut microbiota by corn arabinoxylans: insights from in vitro batch culture fermentation 玉米阿拉伯木聚糖对人体肠道微生物群的调节：来自体外分批培养发酵的见解

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-09 DOI: 10.1016/j.jff.2026.107193

Fatma Boukid , Aline Adler , Wolfram Manuel Brück

{"title":"Modulation of the human gut microbiota by corn arabinoxylans: insights from in vitro batch culture fermentation","authors":"Fatma Boukid , Aline Adler , Wolfram Manuel Brück","doi":"10.1016/j.jff.2026.107193","DOIUrl":"10.1016/j.jff.2026.107193","url":null,"abstract":"<div><div>Arabinoxylans (AX) are dietary fibers with strong prebiotic potential to modulate gut microbiota. Six samples (S1–S5 corn AX; S6 inulin as control) were assessed in a 24-h in vitro fermentation model, evaluating microbial composition and short-chain fatty acid (SCFA) production. Distinct, structure-dependent effects were observed. High-molecular-weight AX (S1, S2) selectively enriched <em>Faecalibacterium</em> and sustained acetate and butyrate production throughout fermentation. Medium molecular weight AX (S3) favored <em>Blautia</em> and <em>Oscillospira</em>, with moderate SCFA accumulation. Low molecular weight AX (S4, S5) promoted <em>Blautia</em>, <em>Collinsella</em>, and <em>Faecalibacterium</em>, supporting gradual and sustained SCFA release. In contrast, inulin (S6) stimulated <em>Akkermansia</em> and <em>Collinsella</em>, inducing a rapid early increase in acetate and lactate followed by a decline. Overall, AX molecular weight and structure critically shape microbial responses and metabolic outputs, with high-molecular-weight AX enabling prolonged butyrogenic activity, while inulin drives fast, short-lived fermentation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107193"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seaweed-derived bioactives and nutrition: Emerging functional strategies for cardiovascular disease prevention 海藻衍生的生物活性物质和营养：心血管疾病预防的新兴功能策略

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.jff.2026.107207

Saurabh Sharma, Alka Mehta

{"title":"Seaweed-derived bioactives and nutrition: Emerging functional strategies for cardiovascular disease prevention","authors":"Saurabh Sharma, Alka Mehta","doi":"10.1016/j.jff.2026.107207","DOIUrl":"10.1016/j.jff.2026.107207","url":null,"abstract":"<div><div>Seaweeds, a form of marine macroalgae, possess a lengthy history of application in both edible and traditional medical treatment of a range of diseases. They are notable for their rich nutritional profile, including a range of phytochemicals that act as antioxidants, minerals, vitamins, vital amino acids, as well as dietary fibers. Potential bioactive compounds obtained from seaweed, including fucoidan, sulfated polysaccharides, polyphenols, sterols, fucoxanthin, even omega-3 fatty acid, have been attracting a lot of interest. These bioactive compounds help to lowering low-density lipoprotein (LDL), cholesterol, risk of atherosclerosis, hypertension, prevention and management of cardiovascular diseases (CVDs). Based on recent data from 2019, 523 million people were affected globally by CVD, and this caused 18.6 million fatalities. This number is predicted to increase 24 million by 2030 worldwide. In this review, epidemiological studies supporting the cardiovascular benefits of seaweed consumption are discussed, alongside the challenges and considerations for their incorporation into functional foods and nutraceuticals. Overall, this review emphasizes the significant potential of seaweeds as sustainable sources of functional ingredients for cardiovascular health promotion and identifies key areas for future research.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"138 ","pages":"Article 107207"},"PeriodicalIF":4.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146171676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0