Journal of Functional Foods最新文献_第4页

Jinhua Hecha – A fermented green tea improves sleep via regulating glutamatergic synapses and gut microbiota 金华黑茶--一种通过调节谷氨酸能突触和肠道微生物群改善睡眠的发酵绿茶

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106550

Yingying Wang , Xunjie Zheng , Ke Li , Jianli Gao , Jianbo Huang , Zhaohuan Lou

{"title":"Jinhua Hecha – A fermented green tea improves sleep via regulating glutamatergic synapses and gut microbiota","authors":"Yingying Wang , Xunjie Zheng , Ke Li , Jianli Gao , Jianbo Huang , Zhaohuan Lou","doi":"10.1016/j.jff.2024.106550","DOIUrl":"10.1016/j.jff.2024.106550","url":null,"abstract":"<div><div>Quality sleep is crucial for preserving the internal equilibrium of the body. Sleep problems have become a predominant global health concern in recent years. Jinhua Hecha (JHHC) is a fermented green tea characterized by high amino acid and low tea polyphenols. In animal experiments, the potential beneficial effects of JHHC on sleep quality were evaluated. 50 mice were categorized into five groups: the normal control (NC) group, the FFZR positive control group, the JHHCG (2.3 g/kg) group, the JHHCZ (1.6 g/kg) group, and the JHHCD (0.7 g/kg) group. The sleep experiments revealed that mice from the JHHC group exhibited a notably extended duration of sleep following the intraperitoneal injection of pentobarbital sodium, with a shortened sleep latency after injection of barbital sodium. These results suggest that JHHC is beneficial for sleep. Mechanistically, transcriptome KEGG enrichment analysis revealed that differentially expressed genes were significantly enriched in the glutamatergic synapse signaling pathway. Immunohistochemistry and multiple immunofluorescence techniques showed decreased protein expressions of GLS, VGLUT2, GluA2, GluA4, GluK1, and mGluR1 in the colon of the JHHC group. Furthermore, an increase in beneficial bacteria such as Lactobacillus, Ligilactobacillus, and Akkermansia, as well as a decrease in Alistipes, were observed in the JHHC group. These results indicate that JHHC can improve sleep, with potential mechanisms involving gut microbiota maintenance and glutamate level reduction.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106550"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tea intervention ameliorated metabolic dysfunction caused by circadian rhythm disorders via gut microbiota-bile acid-FXR axis 茶干预通过肠道微生物群-胆汁酸-FXR 轴改善昼夜节律紊乱引起的代谢功能障碍

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106566

Yang Wei, Siwei Miao, Kang Wei, Lanlan Peng, Xinlin Wei

{"title":"Tea intervention ameliorated metabolic dysfunction caused by circadian rhythm disorders via gut microbiota-bile acid-FXR axis","authors":"Yang Wei, Siwei Miao, Kang Wei, Lanlan Peng, Xinlin Wei","doi":"10.1016/j.jff.2024.106566","DOIUrl":"10.1016/j.jff.2024.106566","url":null,"abstract":"<div><div>With the rapid development of society and changing lifestyles, people often encounter circadian rhythm disorder (CRD). Although tea active components have shown promise in improving CRD, a comprehensive comparison of different types of tea in improving CRD is still lacking, and the mechanism of regulating CRD-induced metabolic disorders remained unclear. This study selected three representative teas (Green tea, black tea, and dark tea) and compared the ameliorative effects of different teas on CRD-induced metabolic dysfunction. Furthermore, tea intervention improved the metabolic syndrome associated with CRD mainly through decreasing relative abundance of BSH-producing microbes, increasing conjugated bile acids (BAs) that act in an antagonistic manner on intestinal farnesoid X receptor (FXR), and promoting elimination of BAs via the feces. Our results shed light into the mechanisms behind the ameliorative effect of tea intervention on metabolic dysfunction caused by CRD, and suggest that the gut microbiota-bile acid-FXR axis may be potential therapies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106566"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway 萎缩性真菌（无柄灵芝）通过下调CCL28/CCR10通路抑制肿瘤微环境中Treg的招募

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106573

Lu Jin , Jianhui Fu , Xiaochen Lin , Lushuai Jin , Yingxue Guo , Xia Liu , Shaden A.M. Khalifa , Hesham R. El-Seedi , Huiying Fu , Qiyang Shou

{"title":"Saprophytic fungus (Ganoderma sessile) restrained Treg recruitment in the tumor microenvironment by down-regulating CCL28/CCR10 pathway","authors":"Lu Jin , Jianhui Fu , Xiaochen Lin , Lushuai Jin , Yingxue Guo , Xia Liu , Shaden A.M. Khalifa , Hesham R. El-Seedi , Huiying Fu , Qiyang Shou","doi":"10.1016/j.jff.2024.106573","DOIUrl":"10.1016/j.jff.2024.106573","url":null,"abstract":"<div><div><em>Ganoderma sessile</em>, a saprophytic fungus, is a traditional Chinese medicinal material used in Chinese folk medicine and cuisine for its potential to enhance cancer patients immunity in clinical practice. However, the underlying mechanisms of its therapeutic effects remain elusive. Therefore, we explored the edible value to determine the underlying mechanisms of GS through multiple breast cancer models. GS was found to suppress tumor growth and lung metastasis, and prolong survival after surgery. It significantly increased tumor-infiltrating CD44<sup>Hi</sup>CD62L<sup>Hi</sup>CD8<sup>+</sup> T<sub>CM</sub> cells while decreasing CD4<sup>+</sup>CD25<sup>+</sup>CD127<sup>−</sup> Treg cells in both lymph nodes and tumors. The mechanism behind GS’s effects primarily involved modulation of the Hif1-a/CCL28 pathway associated with Treg recruitment. Furthermore, GS could reduce CCR10 levels on the surface of Tregs. Collectively, GS inhibits tumor growth and pulmonary metastasis by restraining Treg recruitment through downregulation of the CCL28/CCR10 pathway—a finding which highlights its potential as a natural anti-tumor immune agent warranting further exploration.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106573"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syringin as a novel therapeutic agent for renal cell carcinoma by targeting EGFR/PI3K/Akt pathway and enhancing sunitinib efficacy 通过靶向表皮生长因子受体/PI3K/Akt通路和增强舒尼替尼疗效，将Syringin作为肾细胞癌的新型治疗剂

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-13 DOI: 10.1016/j.jff.2024.106556

Zixuan Chen , Sheng Cheng , An Xu , Chengtao Han , Xing Jia , Min Liu

{"title":"Syringin as a novel therapeutic agent for renal cell carcinoma by targeting EGFR/PI3K/Akt pathway and enhancing sunitinib efficacy","authors":"Zixuan Chen , Sheng Cheng , An Xu , Chengtao Han , Xing Jia , Min Liu","doi":"10.1016/j.jff.2024.106556","DOIUrl":"10.1016/j.jff.2024.106556","url":null,"abstract":"<div><div>Syringin, a natural bioactive compound extracted from <em>Acanthopanax senticosus</em>, has demonstrated potential therapeutic value in cancer treatment. However, its efficacy in treating renal cell carcinoma (RCC) remains unexplored. This study aims to investigate the therapeutic effects and underlying mechanisms of Syringin in RCC. In this study, network pharmacology, molecular docking validation, and bioinformatics were employed to predict the mechanisms by which Syringin affects RCC. In vitro experiments showed that Syringin inhibited RCC cell viability and reduced the IC50 of Sunitinib, enhancing its therapeutic effect. Syringin also inhibited RCC cell proliferation and migration and promoted apoptosis. The combination of Syringin and Sunitinib demonstrated an enhanced inhibitory effect. Western blot analysis confirmed that Syringin’s anti-RCC effects are mediated through the EGFR/PI3K/Akt pathway. In conclusion, our findings indicate that Syringin exhibits inhibitory effects on RCC cells and enhances their sensitivity to Sunitinib, offering a novel approach to exploring treatment strategies for Sunitinib-resistant RCC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106556"},"PeriodicalIF":3.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential blood pressure regulatory effect of low molecular weight α-chymotrypsin extract and its peptides from Stichopus japonicus: Peptide-ACE interaction study via in silico molecular docking 从日本螫虾中提取的低分子量α-糜蛋白酶及其多肽的潜在血压调节作用：通过硅学分子对接进行肽-ACE相互作用研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-12 DOI: 10.1016/j.jff.2024.106551

Hyo-Geun Lee , D.P. Nagahawatta , N.M. Liyanage , Yu Ri Choe , Jae-Young Oh , Won-Kyo Jung , Si-Hyeong Park , You-Jin Jeon , Hyun-Soo Kim

{"title":"Potential blood pressure regulatory effect of low molecular weight α-chymotrypsin extract and its peptides from Stichopus japonicus: Peptide-ACE interaction study via in silico molecular docking","authors":"Hyo-Geun Lee , D.P. Nagahawatta , N.M. Liyanage , Yu Ri Choe , Jae-Young Oh , Won-Kyo Jung , Si-Hyeong Park , You-Jin Jeon , Hyun-Soo Kim","doi":"10.1016/j.jff.2024.106551","DOIUrl":"10.1016/j.jff.2024.106551","url":null,"abstract":"<div><div>Hypertension is a significant risk factor for cardiovascular disease and heart damage. <em>Stichopus japonicus</em> (<em>S. japonicus</em>) is a red sea cucumber with antioxidant and anti-hypertensive activities. However, its anti-hypertensive mechanism remains unclear. In this study, we evaluated the inhibitory effects of angiotensin-converting enzyme (ACE) of α-chymotrypsin-assisted hydrolysate of <em>S. japonicus</em> (α-chy) and its ultrafiltrate fractions (>10 kDa [α-chy-I], 5–10 kDa [α-chy-II], and <5 kDa [α-chy-III]). Low molecular α-chy-III exerted excellent ACE inhibitory and anti-hypertensive activities in spontaneously hypertensive rats (SHR). Moreover, α-chy-III significantly reduced the systolic and diastolic blood pressure by modulating the serum angiotensin and ACE levels. Histological analysis revealed that α-chy-III markedly protected the aorta, heart, and kidney tissues of SHR from hypertension-induced tissue damage.</div><div>Taken together, our findings highlight the potential of α-chy-III as a functional food ingredient for the treatment of hypertension and its comorbidities.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"123 ","pages":"Article 106551"},"PeriodicalIF":3.8,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxyresveratrol from mulberry (Morus alba L.) ameliorates post-inflammatory hyperpigmentation in vitro by anti-melanogenesis, inhibiting melanosome transfer, and providing photoprotection 桑椹（Morus alba L.）中的氧白藜芦醇通过抗黑色素生成、抑制黑色素小体转移和提供光保护，改善体外炎症后色素沉着

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-01 DOI: 10.1016/j.jff.2024.106557

Hao Wang , Xueping Chen , Jing Li , Zixiang Chen , Aijing Zhou , Li Ye

{"title":"Oxyresveratrol from mulberry (Morus alba L.) ameliorates post-inflammatory hyperpigmentation in vitro by anti-melanogenesis, inhibiting melanosome transfer, and providing photoprotection","authors":"Hao Wang , Xueping Chen , Jing Li , Zixiang Chen , Aijing Zhou , Li Ye","doi":"10.1016/j.jff.2024.106557","DOIUrl":"10.1016/j.jff.2024.106557","url":null,"abstract":"<div><div>Mulberry (<em>Morus alba</em> L.) twigs are a traditional Chinese medicine and edible agricultural by-product. Oxyresveratrol (OXY) is one of the natural resorcinol-type polyphenols obtained from mulberry twigs with anti-melanogenesis effects. This study aimed to investigate the ameliorative effects and mechanisms of OXY on post-inflammatory hyperpigmentation (PIH) <em>in vitro</em>. The results of DPPH radical scavenging and tyrosinase inhibition assays showed that OXY exhibited potent antioxidant and tyrosinase inhibitory activities. In human melanocytes, OXY significantly down-regulated protein expression related to melanin synthesis and transport. A molecular docking study suggested that OXY could inhibit these GTPases (RAB27A, RAC1, and CDC42) activities in melanosome transfer processes. Furthermore, OXY significantly reduced inflammatory factor secretion, promoted human β-defensin production, and up-regulated the expression of barrier proteins in UVB-induced human keratinocytes. This research indicated that the OXY from mulberry twigs has potential applications in ameliorating PIH through its antioxidant, anti-melanogenic, melanosome transport inhibition, anti-inflammatory, and photoprotective properties.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106557"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development, basic information, classifications, pharmacological activities, and underlying mechanisms of medicine food homology: A review 药食同源的发展、基本信息、分类、药理活性和基本机制：综述

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-01 DOI: 10.1016/j.jff.2024.106552

Zhenguo Lv , Lu Chen , Huizi Ouyang , Yameng Zhu , Jinyue Ma , Kaili Zhang , Wenhan Lin , Wenwen Li , Zijing Zhang , Jun He

{"title":"Development, basic information, classifications, pharmacological activities, and underlying mechanisms of medicine food homology: A review","authors":"Zhenguo Lv , Lu Chen , Huizi Ouyang , Yameng Zhu , Jinyue Ma , Kaili Zhang , Wenhan Lin , Wenwen Li , Zijing Zhang , Jun He","doi":"10.1016/j.jff.2024.106552","DOIUrl":"10.1016/j.jff.2024.106552","url":null,"abstract":"<div><div>Medicine food homology is a special existence that combines the therapeutic effects of medicine and the nutritional value of food, making it possible for people to obtain health through daily diet. In this review, not only the concept, origin, and development of medicine food homology were introduced, but also the basic information of 102 medicine food homology substances authoritatively released by the Chinese Ministry of Health were summarized in detail and classified according to different methods. Moreover, the major pharmacological activities and underlying mechanisms of these 102 substances were concluded, and several creative ideas were proposed for the future development of new medicine food homology substances in the future. Collectively, this review provided a scientific basis and theoretical reference for the further exploration and utilization of new medicine food homology substances. Overall, the study of medicine food homology possesses a broad development prospect and great application value.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106552"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gypenoside granules alleviate vascular smooth muscle cell phenotypic switching in atherosclerosis through impeding MAPK/KLF4 pathway 天麻素颗粒通过抑制 MAPK/KLF4 通路缓解动脉粥样硬化中血管平滑肌细胞表型的转换

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-01 DOI: 10.1016/j.jff.2024.106543

Zhi-Wei Zhao , Wei Xu , Ya-Ping Huang , Yuan-Yuan Liu , Yuan Teng , Long Mu , Zi-Yuan Wang , Tian Li , Zhao-Yang Gao , Najihah Mohd Hashim , Ke Pan , Jian Zhang , Lei Wang , Zhi-Qi Yin

{"title":"Gypenoside granules alleviate vascular smooth muscle cell phenotypic switching in atherosclerosis through impeding MAPK/KLF4 pathway","authors":"Zhi-Wei Zhao , Wei Xu , Ya-Ping Huang , Yuan-Yuan Liu , Yuan Teng , Long Mu , Zi-Yuan Wang , Tian Li , Zhao-Yang Gao , Najihah Mohd Hashim , Ke Pan , Jian Zhang , Lei Wang , Zhi-Qi Yin","doi":"10.1016/j.jff.2024.106543","DOIUrl":"10.1016/j.jff.2024.106543","url":null,"abstract":"<div><div>Phenotypic switching of vascular smooth muscle cells (VSMCs) is crucial in atherosclerosis. Gypenoside granules, used clinically for hyperlipidemia, show significant atheroprotective effects, but their impact on VSMC phenotypic switching is unclear. This study evaluated the effects and mechanisms of gypenoside granules on VSMC phenotypic switching. Using ApoE<sup>−/−</sup> mice on a high-fat diet, the study found that gypenoside granules reduced blood lipid levels, decreased necrotic core areas, increased fibrous cap thickness, and inhibited inflammation. In PDGF-BB-induced VSMCs, gypenoside granules suppressed phenotypic switching, proliferation, and migration by downregulating KLF4 expression. The beneficial effects were reversed by KLF4 overexpression. HPLC analysis identified ten key components in the granules. These findings suggest that gypenoside granules may alleviate atherosclerosis by modulating the MAPK/KLF4 pathway and could serve as an alternative treatment for the disease.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106543"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig 初榨椰子油通过减少哮喘豚鼠体内转化生长因子 β 的表达，防止气道重塑并恢复气管松弛反应性

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-01 DOI: 10.1016/j.jff.2024.106544

Luiz Henrique César Vasconcelos , Maria da Conceição Correia Silva , Alana Cristina Costa , Giuliana Amanda de Oliveira , Iara Leão Luna de Souza , Rubens da Silva Araújo , Adriano Francisco Alves , Fabiana de Andrade Cavalcante , Bagnólia Araújo da Silva

{"title":"Virgin coconut oil prevents airway remodeling and recovers tracheal relaxing reactivity by reducing transforming growth factor β expression on asthmatic guinea pig","authors":"Luiz Henrique César Vasconcelos , Maria da Conceição Correia Silva , Alana Cristina Costa , Giuliana Amanda de Oliveira , Iara Leão Luna de Souza , Rubens da Silva Araújo , Adriano Francisco Alves , Fabiana de Andrade Cavalcante , Bagnólia Araújo da Silva","doi":"10.1016/j.jff.2024.106544","DOIUrl":"10.1016/j.jff.2024.106544","url":null,"abstract":"<div><div>Asthma is a chronic inflammatory disease with many patients failing to respond appropriately to pharmacotherapy. Thus, virgin coconut oil (VCO) can be an alternative therapy. Guinea pigs were divided into control (Ctrl), chronic allergic lung inflammation (Asth), Asth treated with dexamethasone (Asth + dexa), and Asth supplemented with VCO (Asth + VCO4). The tested animals were sensitized and challenged with ovalbumin. Relaxation induced by arachidonic acid (AA) was impaired in Asth, and this reduction was prevented by VCO (p = 0.0004), indicating formation of relaxing prostanoids, or the decrease of cysteinyl-leukotrienes by VCO. Furthermore, a possible negative modulation of β receptors/BK<sub>Ca</sub> pathway by TGF–β in Asth was prevented by VCO (p = 0.0073). Finally, in Asth, Masson’s trichrome staining revealed airway remodeling and immunohistochemistry showed increased TGF-β expression in the lungs of Asth (p < 0.0001)), which was prevented by VCO and dexamethasone (p < 0.0001), concluding VCO as a possible agent against asthma.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106544"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lacticaseibacillus rhamnosus CCFM1060 Modulates gut microbiota and intestinal barrier Function: Alcoholic liver disease Mitigation through Nrf2/HO-1 and NF-κB Pathways 鼠李糖乳杆菌 CCFM1060 可调节肠道微生物群和肠屏障功能：通过 Nrf2/HO-1 和 NF-κB 途径缓解酒精性肝病

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-11-01 DOI: 10.1016/j.jff.2024.106516

Ben Niu , Lijuan Huang , Xu Cheng , Zhangming Pei , Hongchao Wang , Fengwei Tian , Wenwei Lu

{"title":"Lacticaseibacillus rhamnosus CCFM1060 Modulates gut microbiota and intestinal barrier Function: Alcoholic liver disease Mitigation through Nrf2/HO-1 and NF-κB Pathways","authors":"Ben Niu , Lijuan Huang , Xu Cheng , Zhangming Pei , Hongchao Wang , Fengwei Tian , Wenwei Lu","doi":"10.1016/j.jff.2024.106516","DOIUrl":"10.1016/j.jff.2024.106516","url":null,"abstract":"<div><div>Long-term and/or excessive ethanol intake can lead to alcoholic liver disease (ALD). Gut dysbiosis contributes to a critical role in the pathogenesis of ALD. Here, we explored the impact of viable and dead <em>Lacticaseibacillus rhamnosus</em> CCFM1060 on the gut microbiota of alcohol-treated mice. The findings indicated that CCFM1060 V and D (viable and dead) administration improved the gut microbiota composition. Specifically, CCFM1060 D restored the abundance of butyric acid-producing bacteria, Alistipes, Lachnospiraceae, and Ruminococcaceae in ethanol-induced mice; CCFM1060 V improved the abundance of <em>g_Dubsiela</em>, <em>g_Bifdobacterium</em>, <em>g_Ruminococcaceae_UCG_014_2</em>, the SCFA-producing bacteria which were decreased in alcoholic hepatitis. Furthermore, the interventions improved the microstructure of the ileum, including the villi and crypts. They reinforced the intestinal barrier by increasing the RNA and protein expression of claudin-1, occludin, and ZO-1 in the colon. Also, they have been shown to enhance the liver’s antioxidant function by suppressing the synthesis of MDA and boosting the concentrations of GSH and SOD through the Nrf2/HO-1 pathway. In addition, interventions can suppress mice’s levels of TNF-α and IL-6, IL-1β in serum, presumably via the TRL4/MyD88/NF-κB pathway. Together, these results suggest that CCFM1060 can modulate the gut microbiota structure, reinforce the intestinal barrier, improve intestinal homeostasis, enhance liver antioxidant capacity, and mitigate inflammation response, eventually protecting the liver from ethanol-induced injury.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106516"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0