Journal of Functional Foods最新文献_第4页

Anoectochilus roxburghii polysaccharide alleviates DSS-induced ulcerative colitis by modulating the MAPK/NF-κB signaling pathway and gut microbiota 刺梨多糖通过调节MAPK/NF-κB信号通路和肠道菌群减轻dss诱导的溃疡性结肠炎

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-09 DOI: 10.1016/j.jff.2025.107018

Shumin Chen , Fenqi Xuan , Zhizhong Zheng , Biyun Ye , Yichao Xu , Liping Huang , Chunbin Zhang , Gang Song

{"title":"Anoectochilus roxburghii polysaccharide alleviates DSS-induced ulcerative colitis by modulating the MAPK/NF-κB signaling pathway and gut microbiota","authors":"Shumin Chen , Fenqi Xuan , Zhizhong Zheng , Biyun Ye , Yichao Xu , Liping Huang , Chunbin Zhang , Gang Song","doi":"10.1016/j.jff.2025.107018","DOIUrl":"10.1016/j.jff.2025.107018","url":null,"abstract":"<div><div>Ulcerative colitis (UC) involves mucosal barrier disruption, immune dysregulation, and gut dysbiosis, with current therapies limited by cost and side effects. This study evaluated the effects of <em>Anoectochilus roxburghii</em> polysaccharide (ARP)—a glucan-rich heteropolysaccharide (888 Da–2.43 × 10<sup>6</sup> Da)—on dextran sulfate sodium (DSS)-induced murine colitis model. ARP (150–300 mg/kg) markedly alleviated colitis by reducing the disease activity index, restoring colon length, and improving histopathology. ARP enhanced intestinal barrier integrity by upregulating ZO-1, OCLN, and MUC2, while suppressing pro-inflammatory cytokines (IL-1<em>β</em>, IL-6, and TNF-<em>α</em>), M1 macrophage polarization, and MAPK/NF-<em>κ</em>B signaling. Transcriptomic and immunoblot analyses confirmed the downregulation of key inflammatory mediators, including phosphorylated p38, JNK, and I<em>κ</em>Bα. ARP also modulated gut microbiota, increasing <em>Bacteroidota</em> and decreasing <em>Proteobacteria</em> <em>abundance</em>. These results provide integrated evidence that ARP exerts multimodal protective effects in UC by targeting barrier dysfunction, immune hyperactivation, and microbial dysbiosis, establishing a mechanistic basis for developing ARP as a functional food and natural dietary intervention for UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107018"},"PeriodicalIF":4.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat-treated culture-dried Lactiplantibacillus Plantarum L-14 suppresses adipogenesis and lipogenesis in 3T3-L1 and HepG2 cells 热处理培养干燥的植物乳杆菌L-14抑制3T3-L1和HepG2细胞的脂肪生成和脂肪生成

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-08 DOI: 10.1016/j.jff.2025.106999

Inwook Kim , Soyeong Park , Jieun Kim , Soyeon Kim , Na Rae Hwang , Byeong Soo Eom , Sangkyu Park , Jeongmin Seo

{"title":"Heat-treated culture-dried Lactiplantibacillus Plantarum L-14 suppresses adipogenesis and lipogenesis in 3T3-L1 and HepG2 cells","authors":"Inwook Kim , Soyeong Park , Jieun Kim , Soyeon Kim , Na Rae Hwang , Byeong Soo Eom , Sangkyu Park , Jeongmin Seo","doi":"10.1016/j.jff.2025.106999","DOIUrl":"10.1016/j.jff.2025.106999","url":null,"abstract":"<div><div>Obesity is a growing global health issue prompting the development of probiotic-based interventions. This study investigated whether heat-treated culture-dried L14 (HT-L14) retains these benefits. In HepG2 cells, HT-L14 reduced palmitate-induced lipid accumulation suppressed lipogenic genes including sterol regulatory element-binding protein 1 and carbohydrate-responsive element-binding protein, and activated AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), promoting lipid oxidation. In 3T3-L1 cells, HT-L14 inhibited adipocyte differentiation, reduced the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT/enhancer-binding protein alpha (C/EBPα), and increased energy metabolism-related gene expression. RNA sequencing analysis revealed differential gene expression enriched in lipid metabolism and insulin signaling pathways. HT-L14 exhibited no cytotoxicity and demonstrated improved safety compared to live L14 in HepG2 and 3T3-L1 cells. These findings suggest that HT-L14 retains anti-obesity efficacy with enhanced stability, supporting its potential as a therapeutic candidate for obesity and metabolic disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106999"},"PeriodicalIF":4.0,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of polymethoxyflavones on glucose metabolism in a mouse model of cachexia with mutation in the adenomatous polyposis coli gene 多甲氧基黄酮对大肠腺瘤性息肉病基因突变恶病质小鼠模型葡萄糖代谢的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-06 DOI: 10.1016/j.jff.2025.107014

Kiyoka Inenaga, Shin-Ichiro Hino, Takuto Miyazaki

{"title":"Effect of polymethoxyflavones on glucose metabolism in a mouse model of cachexia with mutation in the adenomatous polyposis coli gene","authors":"Kiyoka Inenaga, Shin-Ichiro Hino, Takuto Miyazaki","doi":"10.1016/j.jff.2025.107014","DOIUrl":"10.1016/j.jff.2025.107014","url":null,"abstract":"<div><div>Mice carrying a mutation in the adenomatous polyposis coli (<em>APC</em>) gene (APC<sup>min/+</sup>) exhibit cachexia symptoms, including abnormalities in hepatic glucose metabolism, which are associated with endoplasmic reticulum (ER) stress. APC<sup>min/+</sup> mice are widely known to be associated with abnormalities in the Wnt/β-catenin pathway and gastrointestinal polyp formation. It is unclear whether abnormalities in the Wnt/β-catenin pathway are associated with cachexia in APC<sup>min/+</sup> mice. In this study, we orally administered polymethoxyflavonoids (PMFs) such as 5,7,3′,4′-tetramethoxyflavone (TMF), 7,8,3′,4′-TMF, or Nobiletin, to APC<sup>min/+</sup> mice, and analyzed their effects on cachexia symptoms. We found that APC<sup>min/+</sup> mice gradually lost weight, which was suppressed in the group that was administered PMFs. Furthermore, administration of these PMFs improved abnormal glucose metabolism in APC<sup>min/+</sup> mice. Our results suggest that the improvement in glucose metabolism observed in APC<sup>min/+</sup> mice orally administered PMFs is mediated by normalization of glycolysis or alleviation of hypoxia-induced ER stress.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107014"},"PeriodicalIF":4.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction, structure, biological activities of polysaccharides from tremella fuciformis: A review 银耳多糖的提取、结构及生物活性研究进展

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-06 DOI: 10.1016/j.jff.2025.107012

Yifei Sun , Zainul Abidin Syahariza

引用次数: 0

Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides 益生菌混合物对去糖基化人参皂苷生物转化和生物利用度的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-05 DOI: 10.1016/j.jff.2025.107015

So Yeon Jeon , Jihoon Lee , Ji-Hyeon Jeon , Juyoung Kim , Yeon-Ju Baek , Min-Koo Choi , Soohyun Sung , Jong Won Kim , Sanghyun Lim , Im-Sook Song

{"title":"Effect of a probiotic mixture on the biotransformation and bioavailability of deglycosylated ginsenosides","authors":"So Yeon Jeon , Jihoon Lee , Ji-Hyeon Jeon , Juyoung Kim , Yeon-Ju Baek , Min-Koo Choi , Soohyun Sung , Jong Won Kim , Sanghyun Lim , Im-Sook Song","doi":"10.1016/j.jff.2025.107015","DOIUrl":"10.1016/j.jff.2025.107015","url":null,"abstract":"<div><div>We aimed to investigate the effects of a probiotic mixture comprising <em>Lactiplantibacillus plantarum, Bifidobacterium breve</em>, <em>Bifidobacterium animal</em> subsp. <em>lactis</em>, and <em>Bifidobacterium longum</em> on ginsenoside biotransformation using ginsenoside Rb1 and red ginseng extract. Orally administered Rb1 was metabolized into five deglycosylated ginsenosides and absorbed in the murine gut. Plasma Compound K and protopanaxadiol increased significantly by probiotic mixture and decreased by amoxicillin, without significant change in Rb1 and Rd. This suggest that biotransformation of Compound K and protopanaxadiol are probiotic mixture-susceptible. Incubation of red ginseng extract with probiotic mixture also altered the ginsenoside profile: monoglycosylated ginsenosides and aglycones such as Compound K, protopanaxadiol, and Rh1 increased after 24 h. Their plasma concentrations reflected the altered ginsenoside biotransformation process in the gut by the intervention of probiotic mixture. In conclusion, microbiome activation via probiotic mixture supplementation enhance the systemic availability of mono-glycosylated ginsenoside and aglycone and, consequently, may improve therapeutic efficacy of red ginseng extract.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107015"},"PeriodicalIF":4.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the bioactive capacity of Concord grape (Vitis labrusca) pomace extract on skeletal muscle in a healthy and intestinally inflamed in-vivo model (Gallus gallus): a preliminary study 评价康科德葡萄（Vitis labrusca）渣提取物对健康肠道炎症模型（Gallus Gallus）骨骼肌生物活性的初步研究

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-05 DOI: 10.1016/j.jff.2025.107005

Eliot M. Dugan, Melissa Y. Huang, Elad Tako

{"title":"Evaluating the bioactive capacity of Concord grape (Vitis labrusca) pomace extract on skeletal muscle in a healthy and intestinally inflamed in-vivo model (Gallus gallus): a preliminary study","authors":"Eliot M. Dugan, Melissa Y. Huang, Elad Tako","doi":"10.1016/j.jff.2025.107005","DOIUrl":"10.1016/j.jff.2025.107005","url":null,"abstract":"<div><div>Grape pomace (GP) is among the many food byproducts that are strong candidates for upcycling. GP, rich in polyphenols, is known to influence both intestinal and systemic tissue health and metabolism. Therefore, this study aimed to assess the bioactivity of GP in skeletal muscle (SM) under both intestinally inflamed, dextran sulfate sodium (DSS) challenged, and healthy conditions <em>in-ovo</em> (<em>Gallus gallus)</em>. DSS-challenge induced pro-atrophic phenotypic shifts, reducing myofiber diameter by approximately 35 %, concomitant to nearly 2-fold reductions in myogenic regulatory factors (MRFs), Myogenin and MyoD, gene expression, and enriched fast-glycolytic myofiber type development. These effects were generally abolished by concurrent Concord grape pomace extract (GPE) application. Independently, GPE increased both MRF expression and promoted slow-oxidative fiber type distributions in diseased and healthy cohorts. These findings highlight the connection between intestinal and SM health and demonstrate GP's nutraceutical potential as a bioactive modifier of SM health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107005"},"PeriodicalIF":4.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring by-products as sources of bioactive compounds: LC-ESI-QTOF-MS profiling and bioactivity assessment of blood twig dogwood and cornelian cherry leaf extracts and fractions 探索作为生物活性化合物来源的副产物：血枝茱萸和山茱萸叶提取物和组分的LC-ESI-QTOF-MS分析和生物活性评估

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-04 DOI: 10.1016/j.jff.2025.107002

Maria Concetta Tenuta , Brigitte Deguin , Monica Rosa Loizzo , Fedora Grande , Matteo Brindisi , Maria Antonietta Occhiuzzi , Annabelle Dugay , Marco Bonesi , Giuseppe Antonio Malfa , Rosa Tundis

{"title":"Exploring by-products as sources of bioactive compounds: LC-ESI-QTOF-MS profiling and bioactivity assessment of blood twig dogwood and cornelian cherry leaf extracts and fractions","authors":"Maria Concetta Tenuta , Brigitte Deguin , Monica Rosa Loizzo , Fedora Grande , Matteo Brindisi , Maria Antonietta Occhiuzzi , Annabelle Dugay , Marco Bonesi , Giuseppe Antonio Malfa , Rosa Tundis","doi":"10.1016/j.jff.2025.107002","DOIUrl":"10.1016/j.jff.2025.107002","url":null,"abstract":"<div><div>The increasing incidence of chronic diseases, interest in bioactive compounds from agro-industrial by-products is increasing. This study explored the chemical profile and bioactivities of <em>Cornus mas</em> and <em>Cornus sanguinea</em> leaf extracts obtained through various extraction methods, especially focusing on the lesser-known <em>C. sanguinea</em>. The study assessed their anti-inflammatory properties (inhibition of NF-κB, nitric oxide reduction), antioxidant activity, and hypoglycaemic effects (inhibition of α-amylase and α-glucosidase). LC-ESI-QTOF-MS analysis identified phenolic acids, iridoids, and flavonoids as key constituents. Hydroalcoholic maceration of dried <em>C. mas</em> and ethanol maceration of fresh <em>C. sanguinea</em> were fractionated using XAD-16 resin. Bioactivity was tested on fractions and on three key compounds: sweroside, cornuside, and ellagic acid. Sweroside and cornuside inhibited highly NO production. Moreover, sweroside exhibited a notable α-glucosidase inhibition. These findings highlight the potential benefits of <em>Cornus</em> leaves, providing a basis to develop <em>Cornus</em>-based products for the prevention or treatments for type 2 diabetes and inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107002"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-angiogenic properties of bovine lactoferrin 牛乳铁蛋白的抗血管生成特性

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-04 DOI: 10.1016/j.jff.2025.107007

Yoshiharu Takayama , Reiji Aoki , Ayako Aoki-Yoshida

引用次数: 0

Impact of vitamin D and high-protein diet on muscle quality and daily living activities in elderly diabetic patients with sarcopenia 维生素D和高蛋白饮食对老年糖尿病肌少症患者肌肉质量和日常生活活动的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-04 DOI: 10.1016/j.jff.2025.107000

Xiaojing Wang , Juyun Zhang , Chencui Li , Xiaopan Chen

{"title":"Impact of vitamin D and high-protein diet on muscle quality and daily living activities in elderly diabetic patients with sarcopenia","authors":"Xiaojing Wang , Juyun Zhang , Chencui Li , Xiaopan Chen","doi":"10.1016/j.jff.2025.107000","DOIUrl":"10.1016/j.jff.2025.107000","url":null,"abstract":"<div><div>The individual benefits of vitamin D and protein supplementation in type 2 diabetes mellitus (T2DM) and sarcopenia (SP) are recognized, yet their combined effects in elderly Chinese with different bone mass remain unclear. This study evaluated a three-month intervention of vitamin D (700–1000 IU/day) plus a high-protein diet in 100 elderly patients with T2DM and SP, stratified by bone mass status: normal (<em>n</em> = 21), reduction (<em>n</em> = 45), and osteoporosis (<em>n</em> = 34). Post-intervention, participants showed significant improvements in appendicular skeletal muscle, skeletal muscle index, handgrip strength, short physical performance battery, bone mineral density, serum 25-hydroxyvitamin D3, osteocalcin, and modified Barthel Index. Reductions were observed in procollagen type I amino-terminal peptide, β C-terminal telopeptide of type 1 collagen, fasting glucose, and HbA1c. These findings indicate that combined vitamin D and protein supplementation may enhance musculoskeletal health, metabolic control, and functional independence in elderly patients with T2DM and SP, especially those with low bone mass.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107000"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prolonged treatment with probiotics mitigates intestinal dysfunction and enteric Alzheimer's-related pathology in senescence-accelerated mice 长期使用益生菌治疗可减轻衰老加速小鼠的肠道功能障碍和肠道阿尔茨海默病相关病理

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-03 DOI: 10.1016/j.jff.2025.107016

Vanessa D'Antongiovanni , Clarissa Pierucci , Laura Benvenuti , Annalisa Visciglia , Cristina Segnani , Chiara Ippolito , Luca Antonioli , Matteo Fornai , Giovanni Deusebio , Marco Pane , Angela Amoruso , Nunzia Bernardini , Carolina Pellegrini

{"title":"Prolonged treatment with probiotics mitigates intestinal dysfunction and enteric Alzheimer's-related pathology in senescence-accelerated mice","authors":"Vanessa D'Antongiovanni , Clarissa Pierucci , Laura Benvenuti , Annalisa Visciglia , Cristina Segnani , Chiara Ippolito , Luca Antonioli , Matteo Fornai , Giovanni Deusebio , Marco Pane , Angela Amoruso , Nunzia Bernardini , Carolina Pellegrini","doi":"10.1016/j.jff.2025.107016","DOIUrl":"10.1016/j.jff.2025.107016","url":null,"abstract":"<div><div>The manipulation of gut microbiota represents a potential therapeutic strategy to counteract gut disturbances in patients with age-related cognitive disorders. Here, we investigated the effects of a novel probiotic mixture (PM) in counteracting intestinal symptoms and enteric AD-pathology in an accelerated-senescence mouse model. SAMP8 mice were treated orally with PM at 1 <sub>×</sub> 10<sup>9</sup> CFUAFU strain/mouse/day or placebo for two months. The effects of PM on <em>in vivo</em> colonic transit and <em>in vitro</em> colonic contractile activity were evaluated. Changes in cholinergic, tachykininergic and nitrergic neuron density as well as colonic amyloid-β1–42 (Aβ), HuC/D and IL-1β levels were assessed. Plasma GABA concentrations were also investigated. SAMP8 mice displayed: 1) impairments in colonic transit and <em>in vitro</em> contractility; 2) decrease in myenteric cholinergic, tachykininergic and nitrergic neurons; 3) increase in colonic Aβ1–42 and IL-1β levels and 4) decrease in circulating GABA concentrations. PM restored <em>in vivo</em> and <em>in vitro</em> colonic motility by normalizing enteric cholinergic, tachykininergic and nitrergic neurotransmissions and decreased enteric AD-related protein accumulation and inflammation. Finally, PM induced a modulation of plasma GABA concentrations in SAMP8 mice. Overall, PM supplementation may represent a suitable therapeutic strategy to counteract gut disturbances related to age-related cognitive disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107016"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0