Journal of Functional Foods最新文献_第5页

In vitro gut-models to elucidate how human milk oligosaccharides shape the gut microbiota 体外肠道模型阐明人乳低聚糖如何塑造肠道微生物群

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-03 DOI: 10.1016/j.jff.2025.107011

Ana Belén Peñaherrera-Pazmiño , Gustavo Rosero , Mishell Criollo , Julio Patricio Peñaherrera

{"title":"In vitro gut-models to elucidate how human milk oligosaccharides shape the gut microbiota","authors":"Ana Belén Peñaherrera-Pazmiño , Gustavo Rosero , Mishell Criollo , Julio Patricio Peñaherrera","doi":"10.1016/j.jff.2025.107011","DOIUrl":"10.1016/j.jff.2025.107011","url":null,"abstract":"<div><div>This review explores the important role of human milk oligosaccharides (HMOs). It highlights remarkable properties of HMOs as they act as decoys for disease-causing microbes and prevent their adhesion to the gut epithelium enabling its expulsion from the intestine. The role of HMOs has been researched by conventional methodologies, such as cellular cultures and animal experimentation, yielding significant understanding; however, they are constrained in their ability to accurately emulate the intricacies of human pathology and evoke ethical concerns. Herein, <em>in vitro</em> gut-models (IVGM) applied in studies to elucidate how HMOs shape microbiota are presented. The majority of studies related to HMOs effect on gut microbiota are performed in bioreactors. This review presents a concise overview of this rapidly advancing technology, a cost analysis, an examination of contemporary applications and potential challenges associated with their implementation, and proposes recommendations for future trajectories over the forthcoming decade.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107011"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols 从膳食多酚中提取抗癌天然化合物的机理和临床观点

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-03 DOI: 10.1016/j.jff.2025.106991

Fatiha Ghilane , Nasreddine El Omari , Khang Wen Goh , Ilhame Bourais , Youssef Bakri , Hassan El Btaouri , Abdelhakim Bouyahya

{"title":"Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols","authors":"Fatiha Ghilane , Nasreddine El Omari , Khang Wen Goh , Ilhame Bourais , Youssef Bakri , Hassan El Btaouri , Abdelhakim Bouyahya","doi":"10.1016/j.jff.2025.106991","DOIUrl":"10.1016/j.jff.2025.106991","url":null,"abstract":"<div><div>In recent years, the therapeutic potential of plant-derived molecules has attracted growing scientific and clinical interest, largely due to their pivotal role in the development of chemotherapeutic agents, with approximately 74% of anticancer compounds being directly derived from or inspired by natural sources. Numerous published reviews have explored the pharmacological effects of these compounds; however, others have focused exclusively on the examination of one or two specific molecules that have advanced into clinical trials. Furthermore, the majority of available reviews tend to enumerate a multitude of compounds without providing a detailed analysis of the characteristics and features that enable certain plant-derived molecules to progress to the clinical phases. The objective of this review is to elucidate the mechanisms of action of 17 molecules derived from plants clinically tested have been shown to regulate critical cellular processes in cancer cells, including cell cycle arrest, autophagy, and endoplasmic reticulum stress. By emphasizing the common characteristics and distinct properties that confer clinical utility on these molecules, this work provides valuable insights into their translational potential. Additionally, this review also discusses the various drug delivery technologies that have been employed to several challenges that hinder their clinical effectiveness, including limited solubility, poor bioavailability, and low stability.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106991"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of short-Chain fatty acids in gut and skin: Possible implications in skin aging 肠道和皮肤中短链脂肪酸的研究进展：可能与皮肤老化有关

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-03 DOI: 10.1016/j.jff.2025.107010

Sibin Nambidi , Neeharika Sara Sennie , Suresh Babu Kondaveeti , Antara Banerjee , Surajit Pathak , Asim K. Duttaroy

{"title":"A review of short-Chain fatty acids in gut and skin: Possible implications in skin aging","authors":"Sibin Nambidi , Neeharika Sara Sennie , Suresh Babu Kondaveeti , Antara Banerjee , Surajit Pathak , Asim K. Duttaroy","doi":"10.1016/j.jff.2025.107010","DOIUrl":"10.1016/j.jff.2025.107010","url":null,"abstract":"<div><div>The gut–skin axis is an active and bidirectional communication in which gut microbiota impacts skin health and disease. One of the most common microbial metabolites is short-chain fatty acids (SCFAs), which are composed of acetate, propionate, and butyrate generated from the fermentation of dietary fibers. SCFAs are bioactive in nature that are essential in regulating inflammation, immune signalling, oxidative stress, and skin barrier function. In addition, SCFAs stimulate the differentiation of keratinocytes, acetylation of collagen, and have antimicrobial properties, which are important in establishing skin homeostasis and longevity. Currently, new approaches are underway to develop dietary patterns, probiotic strategies, functional food, and delivery systems to induce SCFA generation and function in vivo. Relevant research and review articles were collected using databases such as PubMed, Google Scholar, and Scopus for the information required for this comprehensive review. Key terms used for literature search included gut-skin axis, SCFA, functional food, epithelial integrity, skin aging, inflammation, etc. In this review, we tried to summarised the role and mechanisms of SCFA in gut-skin aging from the published research evidence and discussed on the role of functional foods in managing aging-related diseases.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107010"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioaccessibility and anti-inflammatory activity in Caco-2 cells of phytochemicals from industrial by-products of coffee (Coffea arabica L.) 咖啡工业副产品植物化学物质在Caco-2细胞中的生物可及性和抗炎活性

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-03 DOI: 10.1016/j.jff.2025.107008

Milena Jiménez-Gutiérrez , Christian Zielinski , Patricia Esquivel , Jan Frank , Andrea Irías-Mata , Felipe Jiménez-Aspee

{"title":"Bioaccessibility and anti-inflammatory activity in Caco-2 cells of phytochemicals from industrial by-products of coffee (Coffea arabica L.)","authors":"Milena Jiménez-Gutiérrez , Christian Zielinski , Patricia Esquivel , Jan Frank , Andrea Irías-Mata , Felipe Jiménez-Aspee","doi":"10.1016/j.jff.2025.107008","DOIUrl":"10.1016/j.jff.2025.107008","url":null,"abstract":"<div><div>Coffee by-products are rich in nutrients and bioactive compounds in free soluble form and bound to cell wall components. These compounds undergo chemical changes during gastrointestinal digestion, affecting their bioaccessibility and bioactivity. This study is the first to investigate coffee by-products from industrial wet processing to evaluate the impact of simulated gastrointestinal digestion on their phytochemical composition and subsequent anti-inflammatory activity in Caco-2 cells. Digestion significantly reduced the stability and solubility of main compounds; however, digested bioaccessible by-products still exhibited anti-inflammatory properties, reducing IL-6, IL-8, and TNF-α levels. Correlation analysis identified rutin, quercetin-3-glycoside, caffeine and 5-caffeoylquinic acid as strongly linked to cytokine suppression, suggesting key roles and possible synergies. These results highlight the potential of coffee by-products as functional ingredients targeting intestinal inflammation. Future work should confirm <em>in vivo</em> efficacy, optimize extraction at scale, and address regulatory requirements to support industrial application and promote circular economy benefits.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107008"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginkgolide B promotes stem cell homing and neuronal differentiation by Wharton's jelly mesenchymal stem cell-derived exosomes in a Parkinson's disease cell model 银杏内酯B在帕金森病细胞模型中通过沃顿果冻间充质干细胞衍生的外泌体促进干细胞归巢和神经元分化

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-02 DOI: 10.1016/j.jff.2025.107003

William Shao-Tsu Chen , Wei-Wen Kuo , Bruce Chi-Kang Tsai , Chia-Hua Kuo , Samiraj Ramesh , Shih-Chieh Liao , Shih-Wen Kao , Yu-Jung Lin , Chih-Yang Huang , Shinn-Zong Lin

{"title":"Ginkgolide B promotes stem cell homing and neuronal differentiation by Wharton's jelly mesenchymal stem cell-derived exosomes in a Parkinson's disease cell model","authors":"William Shao-Tsu Chen , Wei-Wen Kuo , Bruce Chi-Kang Tsai , Chia-Hua Kuo , Samiraj Ramesh , Shih-Chieh Liao , Shih-Wen Kao , Yu-Jung Lin , Chih-Yang Huang , Shinn-Zong Lin","doi":"10.1016/j.jff.2025.107003","DOIUrl":"10.1016/j.jff.2025.107003","url":null,"abstract":"<div><div>Parkinson Stem cell therapy offers potential benefits for Parkinson ’s disease (PD) through neuronal repair and functional restoration of the brain; however, its effectiveness is hindered by limited cell survival, inadequate differentiation, and low homing of the transplanted cells. Ginkgolide B (GB), a bioactive compound found in <em>Ginkgo biloba</em>, has neuroprotective properties. This study examined the impact of GB on Wharton's jelly mesenchymal stem cells (WJMSCs) and their exosomes for potential use in PD therapy. GB enhanced WJMSC homing by upregulating CXCR4, CXCR7, and SDF-1 while reducing OCT4 and Nanog. GB also increased neural differentiation markers, including CD133, BDNF, and phospho-IGF1-R, accompanied by β-catenin nuclear translocation. Exosomes from GB-treated WJMSCs were larger and more effective in promoting neuronal differentiation, as demonstrated by increased BDNF levels and NeuN-positive cells. These results suggest that GB enhances WJMSC differentiation and exosome function, supporting its use as an adjunct in stem cell–based PD treatments.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107003"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of pre/pro/synbiotics on cardiometabolic health in patients with polycystic ovary syndrome: A systematic review, meta-analysis and meta-evidence 前/前/合成药物对多囊卵巢综合征患者心脏代谢健康的影响：系统回顾、荟萃分析和荟萃证据

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-02 DOI: 10.1016/j.jff.2025.106996

Nian Liu , Xinwei Wang , Miao Wang

{"title":"The effect of pre/pro/synbiotics on cardiometabolic health in patients with polycystic ovary syndrome: A systematic review, meta-analysis and meta-evidence","authors":"Nian Liu , Xinwei Wang , Miao Wang","doi":"10.1016/j.jff.2025.106996","DOIUrl":"10.1016/j.jff.2025.106996","url":null,"abstract":"<div><div>Although many studies have revealed the benefits of biotics on health outcomes in women with polycystic ovary syndrome (PCOS), the findings are inconclusive. Scopus, PubMed, Web of Science, Cochran, and Embase were searched to identify RCTs on prebiotics, probiotics and synbiotics on health outcomes. Results of twenty-one RCTs showed high-quality evidence supporting prebiotics or synbiotics effects, in reducing weight (SMD: −0.24, 95 % CI: −0.47, −0.01) BMI (SMD: −0.28, 95 % CI: −0.53, −0.03), moderate-quality evidence for WC (SMD: −0.57, 95 % CI: −0.96, −0.18), MDA (SMD: −0.77, 95 % CI: −1.17, −0.37), TG (SMD: −0.42, 95 % CI: −0.80, −0.04), LDL-C (SMD:−0.44, 95 %CI: −0.88, −0.01), and total testosterone (SMD: −1.30, 95 % CI: −2.02, −0.57) improvements, and led to a moderate-quality evidence increase for TAC (SMD: 0.58, 95 % CI: 0.14, 1.01), and HDL-C (SMD: 0.34, 95 % CI: 0.03, 0.65). Probiotics led to significant reductions in insulin (SMD: −0.66, 95 %CI: −1.18, −0.14), HOMA-IR (SMD: -0.80, 95 %CI: −1.52, −0.09), and TG (SMD: -0.48, 95 %CI: −0.85, −0.11). This meta-analysis suggests that prebiotics, probiotics or synbiotics, might beneficially affect several health outcomes in patients with PCOS.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106996"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propionic acid-rich fermented blueberry supernatant improves DSS-induced colitis symptoms by regulating inflammatory pathways 富含丙酸的发酵蓝莓上清通过调节炎症途径改善dss诱导的结肠炎症状

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-02 DOI: 10.1016/j.jff.2025.107013

Daun Lee , Seon-Kyung Hwang , Sumin Choo , Byungdoo Hwang , Jun-Hui Song , Soo Ah. Jeong , Yeong Hwan Jeong , Myeong Gwan Son , Gi Hyeon Kim , Beong Ou Lim , Hoon Kim , Sung-Kwon Moon

{"title":"Propionic acid-rich fermented blueberry supernatant improves DSS-induced colitis symptoms by regulating inflammatory pathways","authors":"Daun Lee , Seon-Kyung Hwang , Sumin Choo , Byungdoo Hwang , Jun-Hui Song , Soo Ah. Jeong , Yeong Hwan Jeong , Myeong Gwan Son , Gi Hyeon Kim , Beong Ou Lim , Hoon Kim , Sung-Kwon Moon","doi":"10.1016/j.jff.2025.107013","DOIUrl":"10.1016/j.jff.2025.107013","url":null,"abstract":"<div><div>This study investigated the anti-inflammatory effects of a short-chain fatty acid (SCFA)-enriched fermented blueberry supernatant (BBS) and its key component, propionic acid (PropA), in both <em>in vitro</em> and <em>in vivo</em> models of colitis. High-performance liquid chromatography confirmed the presence of PropA in BBS at a concentration of 1.86 mg/mL. In LPS-stimulated RAW 264.7 macrophages, BBS significantly reduced nitric oxide, monocyte chemoattractant protein-1, and interleukin-6 production in a dose-dependent manner. Western blotting revealed that BBS suppressed the expression of inducible nitric oxide synthase, COX-2, and NF-κB. In a DSS-induced colitis mouse model, BBS administration significantly improved disease indicators, including body weight loss, colon shortening, and spleen enlargement. Moreover, BBS restored serum IgG and colonic IgA levels and reduced systemic and local inflammatory mediators. These findings highlight the potential of SCFA-enriched fermented blueberry as a functional postbiotic food capable of modulating inflammatory responses through NF-κB and COX-2 signaling pathways in colitis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107013"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanism of tilapia skin antioxidant pentapeptide on atherosclerosis: Inhibition of angiogenesis and oxidative stress 罗非鱼皮抗氧化五肽抗动脉粥样硬化的机制：抑制血管生成和氧化应激

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-09-01 DOI: 10.1016/j.jff.2025.107009

Yi Liu , Huixue Huang , Yizhu Chen , Bomi Ryu , Zhong-Ji Qian

{"title":"Mechanism of tilapia skin antioxidant pentapeptide on atherosclerosis: Inhibition of angiogenesis and oxidative stress","authors":"Yi Liu , Huixue Huang , Yizhu Chen , Bomi Ryu , Zhong-Ji Qian","doi":"10.1016/j.jff.2025.107009","DOIUrl":"10.1016/j.jff.2025.107009","url":null,"abstract":"<div><div>Atherosclerosis (AS), the pathological core of cardiovascular disease, features endothelial dysfunction, inflammation, oxidative stress, and angiogenesis-driven plaque instability. This study investigates the therapeutic potential of tilapia skin-derived pentapeptide Leu-Ser-Gly-Tyr-Gly (LYG) against AS by targeting angiogenesis and oxidative stress. The results show LYG is a structurally stable antioxidant peptide. LYG down-regulates key angiogenic factors, thereby inhibiting angiogenesis. It also activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway to reduce oxidative stress and reduces the expression of oxidized low-density lipoprotein receptor (LOX-1) and angiotensin II type 1 receptor (AT1), thereby improving endothelial function. Furthermore, LYG suppresses the expression and release of both ox-LDL- and LPS-induced inflammatory mediators and adhesion molecules, thereby mitigating atherosclerotic cardiovascular disease (ASCVD). This study elucidates the potential of tilapia skin-derived peptide LYG against AS by inhibiting angiogenesis and protecting endothelial cells, while also offering new insights into high-value utilization of tilapia processing by-products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107009"},"PeriodicalIF":4.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attenuating effect of Lacticaseibacillus rhamnosus SDSP202406 on antibiotic-induced neurotransmitter imbalance in mice 鼠李糖乳杆菌SDSP202406对抗生素诱导小鼠神经递质失衡的减弱作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-30 DOI: 10.1016/j.jff.2025.107006

Qiaoqiao Luo , Fang Tan , Mengli Ma , Zhangsong Luo , Lingyan Zhang

{"title":"Attenuating effect of Lacticaseibacillus rhamnosus SDSP202406 on antibiotic-induced neurotransmitter imbalance in mice","authors":"Qiaoqiao Luo , Fang Tan , Mengli Ma , Zhangsong Luo , Lingyan Zhang","doi":"10.1016/j.jff.2025.107006","DOIUrl":"10.1016/j.jff.2025.107006","url":null,"abstract":"<div><div>Probiotics are active microorganisms beneficial to health when given in sufficient quantities. This study explored the protective effect of <em>Lacticaseibacillus rhamnosus</em> SDSP202406 against antibiotic-induced locomotor disorders using a processed antibiotic mixture to construct locomotor disorders in mice. The results showed that <em>Lacticaseibacillus rhamnosus</em> SDSP202406 significantly increased endurance performance metrics in both swimming and running behavioral paradigms (<em>P</em> < 0.01), significantly decreased the expression of inflammatory factors, increased the superoxide dismutase and decreased the malondialdehyde in the cerebrum. Moreover, it enhanced the expression of brain-derived neurotrophic factor metabolic pathways in the cerebrum. Additionally, correlation analysis revealed relationship between gut microbiota and cerebrum neuroinflammation. It can be hypothesized that oral <em>Lacticaseibacillus rhamnosus</em> SDSP202406 caused the reprogramming of gut microbiota metabolism, promotes neurological homeostasis. The results demonstrated a modulating effect of <em>Lacticaseibacillus rhamnosus</em> on antibiotic-induced locomotor dysfunction in mice, providing a theoretical basis for the development of probiotic preparations to enhance lo-comotor function.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107006"},"PeriodicalIF":4.0,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cinnacassdiol, a novel anti-inflammatory phenylpropanoid from Cinnamomum cassia barks: Insights from an integrated in vitro, in vivo and in silico investigation 肉桂醇，一种新型抗炎苯丙素，来自肉桂树皮：来自体外、体内和计算机综合研究的见解

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-28 DOI: 10.1016/j.jff.2025.107001

Haowei Feng , Yuqi Shu , Qingfa Tang , Yuanyuan Li , Zucan Chen , Wenkai He , Xiaoyu Yang , Huihui Cao , Meng Shao

{"title":"Cinnacassdiol, a novel anti-inflammatory phenylpropanoid from Cinnamomum cassia barks: Insights from an integrated in vitro, in vivo and in silico investigation","authors":"Haowei Feng , Yuqi Shu , Qingfa Tang , Yuanyuan Li , Zucan Chen , Wenkai He , Xiaoyu Yang , Huihui Cao , Meng Shao","doi":"10.1016/j.jff.2025.107001","DOIUrl":"10.1016/j.jff.2025.107001","url":null,"abstract":"<div><div>Inflammation is acknowledged as a pivotal factor in numerous health problems. <em>Cinnamomum cassia</em>, a classic plant with both medicinal and culinary value, is highly recognized for its significant anti-inflammatory properties. In this study, an undescribed phenylpropanoid-glycosyl derivative, named cinnacassdiol (<strong>CCD</strong>) was obtained from the barks of <em>C. cassia</em> and structurally characterized using a combination of HR-ESI-MS, NMR and quantum calculation of optical rotation (OR). Anti-inflammatory evaluation revealed that <strong>CCD</strong> significantly inhibited excessive neutrophil migration in multiple zebrafish models. Molecular docking combined with molecular dynamic (MD) simulations prompted the strong binding affinities and favorable energetical stabilization of <strong>CCD</strong> toward the protein domains of IL-6, TNF-<em>α</em>, IκB<em>α</em> and NF-κB. This prediction was validated in LPS-stimulated zebrafish and RAW 264.7 cell models at both mRNA and protein levels. Overall, this study identified a novel compound from <em>C. cassia</em> and established a robust scientific basis for its development as an anti-inflammatory functional food ingredient.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 107001"},"PeriodicalIF":4.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0