Journal of Functional Foods最新文献

{"title":"Structural modification, total synthesis, and biological activity of natural product piperine: A review","authors":"Nan Wu ,&nbsp;Xiongjie Yin ,&nbsp;Chengyu Cui,&nbsp;Mingjing Zhao,&nbsp;Chonghao Sun,&nbsp;Lili Jin,&nbsp;Changhao Zhang","doi":"10.1016/j.jff.2025.106827","DOIUrl":"10.1016/j.jff.2025.106827","url":null,"abstract":"<div><div>Piperine is the main chemical constituents of the medicinal and edible plant <em>Piper nigrum</em> L. As an alkaloid compound, it is widely used due to its various biological effects, including but not limited to anti-inflammatory, anti-cancer, anti-oxidant, neuroprotective, and lipid-lowering properties. The utilization of piperine as a platform for drug discovery can be employed to enhance the water solubility and bio-availability, thereby facilitating the generation of high-quality drug candidates with distinct targets and improved drug properties. Numerous derivatives of piperine have been developed, leading to significant advancements in the discovery of novel drugs for the treatment of human cancers and other diseases, as well as in the investigation of associated molecular mechanisms. The present review provides a comprehensive overview of the structural modification, total synthesis, and pharmacological effects of piperine, aiming to enhance understanding of the research advancements in this field and offer valuable recommendations for future investigations on piperine.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106827"},"PeriodicalIF":3.8,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced bioaccessibility and anti-inflammatory effect of chrysin nanoemulsion","authors":"Yuna Lee,&nbsp;Eui-Baek Byun","doi":"10.1016/j.jff.2025.106820","DOIUrl":"10.1016/j.jff.2025.106820","url":null,"abstract":"<div><div>Chrysin is a natural flavonoid with potent anti-inflammatory and antioxidant properties; however, its utilization is hindered by poor solubility and bioavailability. In this study, a chrysin-loaded oil-in-water emulsion system (chrysin-ES) stabilized by octenyl succinate anhydride (OSA)-modified starch was developed to overcome these limitations. The resulting chrysin-ES exhibited excellent encapsulation efficiency (99 %), with drug loading of 0.0093 %, a uniform droplet size (82 nm), and stable colloidal properties over 30 days<em>.</em> In an <em>in vitro</em> digestion assay, chrysin-ES displayed a fourfold increase in bioaccessibility compared to raw chrysin. Furthermore, chrysin-ES demonstrated improved permeability in a parallel artificial membrane permeability assay, suggesting enhanced gastrointestinal absorption. It also showed superior anti-inflammatory effects in RAW264.7 macrophages, as confirmed by dose-dependent reductions in LPS-induced ROS, IL-6, and PGE2 levels. These findings indicate that OSA-modified starch-stabilized chrysin-ES holds promise as a delivery system for hydrophobic bioactive compounds like chrysin, with potential utilizations in functional foods and nutraceuticals.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106820"},"PeriodicalIF":3.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of PTSO delivery approaches for gut microbiota modulation in colorectal cancer: A comparative study of microcapsules containing Allium derivatives","authors":"Enrique Guillamón ,&nbsp;Beatriz Navajas-Porras ,&nbsp;Adriana Delgado-Osorio ,&nbsp;Lidia Gil-Martínez ,&nbsp;Nuria Mut-Salud ,&nbsp;Antonio Cuberos-Escobar ,&nbsp;Julia Ruiz Vozmediano ,&nbsp;Silvia Pastoriza de la Cueva ,&nbsp;María Chávarri ,&nbsp;Izaskun Marañón ,&nbsp;Juristo Fonollá ,&nbsp;Encarnación González-Flores ,&nbsp;Alberto Baños ,&nbsp;José Ángel Rufián-Henares","doi":"10.1016/j.jff.2025.106818","DOIUrl":"10.1016/j.jff.2025.106818","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with gut microbiota modulation emerging as a critical factor in its development. Propyl propane thiosulfonate (PTSO), an organosulfur compound derived from <em>Allium</em> species, has shown potential as a therapeutic agent for CRC due to its antioxidant and anti-inflammatory properties. This study evaluated three PTSO delivery systems (dextrin, pectin microcapsules, and hydroxypropyl methylcellulose capsules) designed to enhance bioavailability and protect PTSO through digestion. We assessed their antioxidant capacity, cytotoxic effects on CRC cells, and impact on short-chain fatty acid (SCFA) production and gut microbiota composition after in vitro digestion and fermentation with feces of healthy individuals and CRC patients. Results demonstrated that each formulation displayed distinct release profiles and antioxidant activities post-digestion and fermentation, with microencapsulated PTSO showing superior stability, bioavailability and the highest antitumoral efficacy in CRC cell lines, achieving an IC50 value of 20.5 μM. Significant differences in SCFA production and gut microbiota modulation were observed across the formulations. Although further in vivo studies are needed to validate these findings and understand long-term effects, PTSO shows promise as a bioactive compound within functional nutrition. Its ability to modulate gut microbiota composition, alongside its enhanced bioavailability through innovative delivery systems, suggests that PTSO could play a key role in the development of dietary strategies aimed at reducing CRC risk and progression.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106818"},"PeriodicalIF":3.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Monascus vinegar on the inflammatory regulation: inflammatory ingredients determination and corresponding effects mechanism analysis","authors":"Huanmei Meng ,&nbsp;Xin Zhang ,&nbsp;Xianglong Zhang ,&nbsp;Ruirui Li ,&nbsp;Hui Zou","doi":"10.1016/j.jff.2025.106825","DOIUrl":"10.1016/j.jff.2025.106825","url":null,"abstract":"<div><div><em>Monascus</em> vinegar (MV) is a typical fermented food with multiple inflammatory regulation components, but the diversity species and variable content of effective compounds hinder the related study. To identify the effective anti-inflammatory ingredients and corresponding mechanism. Transcriptomics, molecular docking (monoligand and polyligand docking) and molecular dynamics simulation analysis were used to find acetic acid and catechin were the core anti-inflammatory ingredients, tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor-α (TNFα) were the target receptors, acetic acid and catechin regulated TNF and NF-κB signaling pathways by acting on TNFα/TNFR1 interaction. Catechin has higher binding affinity (−300 kJ/mol) than acetic acid (−590 kJ/mol), while acetic acid effectively promoted TNFR1-catechin formation. Moreover, RAW264.7 cell assays demonstrated that acetic acid and catechin had the ability to synergically suppress the expression of inflammation-related proteins. Overall, the research provides more valuable references for developing natural functional vinegar to prevent inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106825"},"PeriodicalIF":3.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of nutritional plant-based extracts from Aframomum citratum and Xylopia parviflora in mitigating epididymal and excrement fat accumulation in DIO-C57BL/6 mice","authors":"Achille Parfait Nwakiban Atchan ,&nbsp;Shilpa Talkad Shivashankara Murthy ,&nbsp;Paolo Magni ,&nbsp;François Ferriere ,&nbsp;Gabriel Agbor Agbor ,&nbsp;Jules-Roger Kuiate ,&nbsp;Uma Venkateswaran Manjappara","doi":"10.1016/j.jff.2025.106817","DOIUrl":"10.1016/j.jff.2025.106817","url":null,"abstract":"<div><div>Obesity is a major global health issue, frequently exacerbated by high-fat diets (HFDs), which contribute to adverse metabolic outcomes. This study investigates the efficacy of extracts from nutritional plants <em>Aframomum citratum (C.Pereira) K.Schum</em> and <em>Xylopia parviflora Spruce</em> in modulating selected anthropometric parameters and fat deposition in DIO-C57BL/6 mice. Over 30 days, we observed that the extracts significantly attenuated body mass index (BMI) and apparent fat mass index (aFMI) in treated mice compared to HFD controls. Notably, <em>X. parviflora</em> at 200 mg.kg⁻¹ BW (body weight) effectively reduced both visceral and subcutaneous adipose tissues, while orlistat served as a comparative benchmark. Lipid profile assessments revealed significant decreases in triglycerides, total cholesterol, and fatty acid contents in the epididymal fat pads of treated animals. Gas chromatography-mass spectrometry (GC–MS) analysis confirmed these findings and also indicated that treatment with the extracts enhanced the excretion of fatty acids, suggesting a potential mechanism of lipid malabsorption. Furthermore, histological analyses revealed a marked decrease in adipocyte size in treated groups, indicating a considerable decline in fat deposition. These findings suggest that bioactive compounds, particularly phenolic acids and flavonoids, found in <em>A. citratum</em> and <em>X. parviflora</em> extracts exhibit significant anti-obesity properties, positioning them as promising natural therapeutic agents for managing diet-induced obesity. Future research should focus on elucidating the mechanisms responsible for these effects and assessing their clinical applicability. This study contributes valuable insights into the role of dietary interventions in obesity management, with implications for the development of novel therapeutic strategies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106817"},"PeriodicalIF":3.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of bovine beta-casomorphin-7 (b-BCM7) and its potential impact on microbiota regulation and digestive health","authors":"Miguel Alejandro Escobar-Charry ,&nbsp;María Ximena Quintanilla-Carvajal","doi":"10.1016/j.jff.2025.106812","DOIUrl":"10.1016/j.jff.2025.106812","url":null,"abstract":"<div><div>This review explores the global production and consumption of bovine milk, highlighting its role in human nutrition. Cow's milk production contributes to household income, food security, and provides essential nutrients (Protein 3.2 %, Fat 3,8 %, Carbohydrates 4,5 %, Calcium 0,12 %, Vitamin B6, B12, D, and C), with over 6 billion people consuming it worldwide. Milk has evolved to meet consumer needs, leading to variations such as lactose-free, skim, and fortified milk. Similarly, the differentiation between A1 and A2 milk has emerged in response to growing interest in their potential health effects. Recent research distinguishes milk based on its β-casein (β-CN) composition, particularly the A1 and A2 variants, which differ in digestion due to the release of bioactive peptides like bovine β-casomorphin-7 (b-BCM7). The amount of b-BCM7 released depends on the β-CN type, with the A1 variant linked to potential effects on the digestive, neurological, and immunological systems, potentially affecting, for example, gut motility and inflammatory responses. However, the microbiota is now recognized as a dynamic organ that contributes to bio-individuality, meaning health effects cannot be generalized. This underscores the importance of alternatives such as A2 milk, which releases less b-BCM7 and is believed to have no adverse effects. Despite concerns, milk remains a nutrient-dense superfood often discouraged in modern diets, potentially depriving people of its benefits. Further research is essential to understand the production of b-BCM7 during digestion and its health effects, clarifying whether its impact occurs during digestion and absorption or directly influences microbiota regulation, helping to provide clearer dietary recommendations.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106812"},"PeriodicalIF":3.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inonotus obliquus alleviates proteinuria of MRL/lpr mice by inhibiting ROS-NLRP3-mediated podocyte pyroptosis via facilitating Nrf2 translocation","authors":"Xinxin Sun ,&nbsp;Hui Liao ,&nbsp;Zhaodi Han ,&nbsp;Yuxiang Liu ,&nbsp;Rongshan Li","doi":"10.1016/j.jff.2025.106764","DOIUrl":"10.1016/j.jff.2025.106764","url":null,"abstract":"<div><div>Proteinuria is a main feature of lupus nephritis (LN) in which NLRP3-mediated podocyte pyroptosis further exacerbates proteinuria. Our previous study confirmed the proteinuria-lowering, podocyte-protecting and anti-inflammatory effects of <em>Inonotus obliquus</em> (chaga) in diabetic kidney disease rats. Our <em>in vivo</em> and <em>in vitro</em> studies were conducted in female MRL/lpr mice and human glomerular podocyte cell line treated with IgG from LN patients' serum. Proteinuria changes were detected by urine protein test kit, C3 and ds-DNA by ELISA, renal histopathology and podocyte morphology were studied also. Western blot and RT-PCR were carried out to detect protein and mRNA levels of WT-1, Nephrin, NLRP3, GSDMD-N, Caspase-1 and IL-1β. ROS in podocytes was detected by fluorescent probes and MDA, LDH levels were measured by ELISA, and Nrf2 translocation was detected by immunofluorescence. <em>In vivo</em> study, chaga significantly decreased proteinuria, improved podocyte morphology and kidney pathological changes, meanwhile increased WT-1 and Nephrin expressions and suppressed NLRP3, GSDMD-N, Caspase-1 and IL-1β expressions when compared to the LN model. <em>In vitro</em> study, similar to Nrf2 activator, chaga facilitated Nrf2 translocate from cytosol into nucleus, suppressed ROS, MDA and LDH generation, then mitigated podocyte pyroptosis. The results indicated that the proteinuria-reducing effect of chaga on LN mice may be related to its promotion of Nrf2 translocation, thereby inhibiting NLRP3/Caspase-1/GSDMD-N-mediated podocyte pyroptosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106764"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quinoa alleviates the diabetic symptoms of db/db mice by upregulating insulin signaling and modulating gut microbiota composition","authors":"Liucheng Li ,&nbsp;Xiaoye Hu ,&nbsp;Xuejie Sun,&nbsp;Xiaohong Wei,&nbsp;Hui Zhang,&nbsp;Pingping Wang","doi":"10.1016/j.jff.2025.106813","DOIUrl":"10.1016/j.jff.2025.106813","url":null,"abstract":"<div><div>Quinoa is ideal for dietary intervention or alleviation of type 2 diabetes mellitus, but its effects on diabetes and underlying mechanisms remain unclear. In this study, the effects of dietary regimens with different quinoa ratios on T2DM symptoms, insulin signaling pathways and gut flora were tested by using <em>db/db</em> mice. The results showed that T2DM symptoms in <em>db/db</em> mice were improved after quinoa dietary intervention, including lower fasting blood glucose, weight loss, enhanced glucose tolerance, lower insulin resistance(IR), improved dyslipidemia, and reduced degree of non-alcoholic fatty liver disease (NAFLD). Interestingly, we also demonstrated that the quinoa diet also activated insulin signaling and improved gut flora diversity. The above results demonstrate that quinoa diet can improve T2DM symptoms in <em>db/db</em> mice by activating the PI3K/AKT signaling pathway and altering gut microflora diversity, and that quinoa has potential to be a functional food ingredient and therapeutic agent for the treatment of T2DM.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer) as a potential food ingredient to intervene in osteoporosis: A potential mechanism study on promoting the osteogenic differentiation of MC3T3-E1 cells","authors":"Tianrui Xue ,&nbsp;Tingting Gong ,&nbsp;Wei Zhao,&nbsp;Mingran Zhang,&nbsp;Binfei Lv,&nbsp;Huiping Liu,&nbsp;Qi Xu,&nbsp;Xiaowei Zhang","doi":"10.1016/j.jff.2025.106821","DOIUrl":"10.1016/j.jff.2025.106821","url":null,"abstract":"<div><div>Food-derived peptides with strong calcium-binding and osteogenic activity are promising functional ingredients for osteoporosis intervention. This study aims to explore whether a novel phosvitin phosphopeptide (Glu-Asp-Asp-pSer-pSer, EDDpSpS) with excellent calcium binding ability can promote the osteogenic differentiation of MC3T3-E1 cells and its potential mechanism. Network pharmacology analysis of EDDpSpS regulating osteoblast differentiation identified that the focal adhesion was a key signaling pathway, which is closely related to cell differentiation. Molecular simulations demonstrated that EDDpSpS was strongly bound to the target proteins within the focal adhesion signaling pathway and maintains a stable state. In addition, EDDpSpS had the potential to activate the key target protein Src tyrosine kinase (Src). Results of cell experiments showed that EDDpSpS (&gt; 100 μg/mL) significantly promoted the differentiation and mineralization of MC3T3-E1 cells. Transcriptome analysis verified that the expression of paxillin (PXN), Src, actin beta/gamma 1 (ACTG1), and other osteoblast genes were regulated by EDDpSpS, leading to an up-regulation of the focal adhesion. In this study, the effect and the potential mechanism of EDDpSpS on osteoblast differentiation were clarified. EDDpSpS may be used as an effective dual-effect food ingredient for developing functional foods targeting osteoporosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106821"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical structure and anti-inflammatory activity of a pectin isolated from sweet potato processing by-products","authors":"Wenting Zhang ,&nbsp;Jian Sun ,&nbsp;Chanmin Liu ,&nbsp;Ruixue Yue ,&nbsp;Yi Zhang ,&nbsp;Hong Zhu ,&nbsp;Chen Ma ,&nbsp;Shaoying Deng ,&nbsp;Hainan Ruan","doi":"10.1016/j.jff.2025.106822","DOIUrl":"10.1016/j.jff.2025.106822","url":null,"abstract":"<div><div>This study characterized a pectin polysaccharide named HWSP-1 isolated from sweet potato residue. Structural characterization indicated that HWSP-1 might be composed of →4)-α-D-Gal<em>p</em>A-(1 → with methylated Gal<em>p</em>A and →2)-α-L-Rha<em>p</em>-(1 → as the main chain, decorated with some neutral polysaccharide such as Ara-, Gal- and Glu- in the form of branched chains. In the lipopolysaccharide (LPS)-induced cells model, HWSP-1 down-regulated the mRNA expression of IL-1β, TNF-α, and IL-6 via inhibiting the TLR4/NF-κB/NLRP3 pathway. The results indicated that HWSP-1 could serve as a potential functional food ingredient.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}