Journal of Functional Foods最新文献

{"title":"Dietary supplementation with polyphenol-rich Salicornia ramosissima extracts: Assessing safety, efficacy, and impact on cardiovascular health biomarkers in healthy volunteers","authors":"Ana M. Nájar ,&nbsp;Soledad Pérez-Sánchez ,&nbsp;Carmen del Río ,&nbsp;Carmen Domínguez ,&nbsp;Cristina López Azcárate ,&nbsp;Reyes de Torres ,&nbsp;Marcel Lamana-Vallverdú ,&nbsp;Marina Romero-Bernal ,&nbsp;Ángela González-Díaz ,&nbsp;María de la Luz Cádiz-Gurrea ,&nbsp;Francisco Javier Leyva-Jiménez ,&nbsp;Álvaro Fernández-Ochoa ,&nbsp;Antonio León ,&nbsp;Joan Montaner","doi":"10.1016/j.jff.2024.106539","DOIUrl":"10.1016/j.jff.2024.106539","url":null,"abstract":"<div><div>The importance of diet in preventing non-communicable diseases is well established, with polyphenol consumption suggested to impact cardiovascular disease development. <em>Salicornia ramosissima synthesizes</em> high amounts of phytochemicals under environmental stress. In a randomized controlled clinical trial on 90 healthy volunteers, we evaluated the safety of supplementation with 1 g of polyphenol-rich <em>S. ramosissima</em> extracts from salt marshes and hydroponic sources over three months. No differences in adverse effects were observed between extract-treated and placebo subjects. Salicornia extract from marshes (SM) increased glomerular filtration rate and reduced LDL cholesterol. SM treatment also modulated plasma markers related to cardiovascular disease: MERTK, Gal-9, ADM, TF, PRSS27, HAOX1, IL-18, PAPPA, TNFRSF1A, TIE2 and FGF-21 proteins were downregulated while SRC levels were upregulated. Therefore, under the studied conditions of use, Salicornia extracts consumption is safe and SM induced biochemical and proteomic changes related to cardiovascular health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106539"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of polysacchadride from Psoralea corylifolia in simulated gastrointestinal digestion and microbial fermentation","authors":"Zhenhua Yin ,&nbsp;Juanjuan Zhang ,&nbsp;Qingfeng Guo ,&nbsp;Jiale Zhi ,&nbsp;Xia Zhang ,&nbsp;Wei Zhang ,&nbsp;Lin Chen","doi":"10.1016/j.jff.2024.106549","DOIUrl":"10.1016/j.jff.2024.106549","url":null,"abstract":"<div><div><em>Psoralea corylifolia</em> polysaccharide (PPs) was the bioactive ingredient that conferred health benefits. In this study, simulated digestion and anaerobic fermentation models were employed to explore the digestion and fermentation characteristics of PPs and its effect on the intestinal microbiota. The results revealed that while the total and reducing sugar contents of PPs increased after simulated digestion, their molecular weight, monosaccharide composition, and overall structure remained unchanged, indicating that PPs was not degraded during digestion. On the other hand, during anaerobic fermentation, PPs was metabolized by intestinal microbiota, leading to the production of acetic acid and propionic acid, which subsequently reduced the pH of the fecal culture solution. Additionally, PPs modulated the composition of the intestinal flora, significantly decreasing the relative abundance of Proteobacteria while increasing the relative abundance of Bacteroidota and Firmicutes to varying degrees. This study highlighted the potential of PPs for development as functional foods and therapeutic agents.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106549"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of sleep quality and sub-health conditions through pasteurized fermented milk consumption: A human intervention study","authors":"Jia Zhao ,&nbsp;Hongliang Li ,&nbsp;Lai-Yu Kwok ,&nbsp;Xiuying Wu ,&nbsp;Hongxia Liu ,&nbsp;Xin Shen ,&nbsp;Feiyan Zhao ,&nbsp;Hao Qi ,&nbsp;Hairan Ma ,&nbsp;Zhihong Sun","doi":"10.1016/j.jff.2024.106562","DOIUrl":"10.1016/j.jff.2024.106562","url":null,"abstract":"<div><div>The sub-health state refers to a transitional condition between optimal health and disease, impacting physical, psychological, and social well-being. In this 42-day human intervention trial, we investigated the effects of two pasteurized fermented milks on sub-health symptoms. These pasteurized fermented milks shared the same starter culture and probiotic strains (<em>Lacticaseibacillus paracasei</em> PC-01, <em>Lactiplantibacillus plantarun</em> Lp-6, <em>Lactobacillus helveticus</em> H9, and <em>Bifidobacterium animalis</em> subsp. <em>lactis</em> Probio-M8), differing only in the presence of inulin. Qualified subjects were randomly assigned to the probiotic group (received milk without inulin; n = 49 or synbiotic group (received milk with inulin; n = 51). Outcome measures included Sub-Health Measurement Scale (SHMS) and Pittsburgh Sleep Quality Index (PSQI) scores, fecal metagenomes, metabolomes, and short-chain fatty acids, and serum neurotransmitter levels at baseline, after a 4-week intervention (day 28), and a 2-week-follow-up period (day 42). Our results showed that both pasteurized fermented milks improved sleep quality and alleviated sub-health symptoms, with no significant added benefit from inulin. Fecal metagenome analysis revealed post-interventional changes in gut microbial composition, including increased <em>Bifidobacterium longum</em> and decreased potentially pro-inflammatory bacteria (<em>Blautia</em> sp. and <em>Dorea</em> sp.). Changes in <em>Blautia</em> sp. and <em>B. longum</em> correlated significantly with SHMS and PSQI scores, respectively. Fecal and serum metabolite analysis showed post-interventional modulation of fecal short-chain fatty acids, anti-inflammatory bioactive metabolites, and serum neurotransmitters such as gamma-aminobutyric and serotonin hydrochloride. In conclusion, pasteurized fermented milk intake alleviated sub-health symptoms, affected the gut microbiome, metabolome, and serum metabolites. These findings highlight the potential of pasteurized fermented milk for mitigating sub-health conditions.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106562"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of Sipunculus nudus peptide-calcium chelate: Structural insights and osteogenic bioactivity assessment","authors":"Qianqian Ouyang ,&nbsp;Yuwei Jiang ,&nbsp;Lifen Liu ,&nbsp;Chengfeng Cai ,&nbsp;Nandika Bandara ,&nbsp;Puwang Li ,&nbsp;Kefeng Wu ,&nbsp;Hui Hong ,&nbsp;Liang Chen","doi":"10.1016/j.jff.2024.106497","DOIUrl":"10.1016/j.jff.2024.106497","url":null,"abstract":"<div><div>In order to prepare calcium supplements for efficient absorption and utilization in the human body, this study focused on synthesizing SNP-Ca by chelating <em>Squarrosus nudus</em> peptide (SNP) with calcium. We characterized its structure, stability, and calcium uptake properties in Caco-2 cells and its impact on osteogenic activity in vitro. Optimal preparation conditions were determined: a peptide-calcium mass ratio of 5:1, a 30-min reaction time, a temperature of 60 °C, and a pH of 7.0. Under these conditions, a calcium chelating rate of 68.32 % was achieved. Calcium binds to the peptide primarily via carboxyl oxygen and amino nitrogen atoms, and the morphology of SNP-Ca was similar to porous nanoflowers. Our cellular experiments revealed that SNP-Ca significantly increases calcium uptake in Caco-2 cells, stimulating proliferation, differentiation, and mineralization in MC3T3-E1 cells. Additionally, zebrafish larvae models showed enhanced bone formation following SNP-Ca administration. SNP-Ca has the potential of a novel calcium supplement.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106497"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of AP collagen peptides (APCPs) on hair shaft elasticity and gloss: A comprehensive analysis","authors":"Ahreum Kim ,&nbsp;Yujin Kim ,&nbsp;Jung Min Lee ,&nbsp;Jin-Oh Chung ,&nbsp;Jong Hwa Roh ,&nbsp;Jung Ok Lee ,&nbsp;Beom Joon Kim","doi":"10.1016/j.jff.2024.106534","DOIUrl":"10.1016/j.jff.2024.106534","url":null,"abstract":"<div><div>AP collagen peptides (APCPs) are enzymatically decomposed collagen peptides that have been shown to promote hair growth and improve hair cuticle structure and thickness in mice. However, their impact on the elasticity and gloss of human hair has not been thoroughly investigated. Therefore, this study sought to identify the factors affecting hair elasticity and gloss in APCPs-treated human hair follicles (hHFs). Using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) analysis, changes in amino acid content related to hair elasticity and lipid components associated with hair gloss were measured. As a result, APCP treatment led to increases in proline and cysteine amino acid, as well as in lipid components such as 18-methyleicosanoic acid (18-MEA), lauric acid, oleic acid, 11,13-eicosenoic acid, behenic acid, methyleicosanoic acid and squalene. Fourier-transform infrared spectroscopy (FT-IR) analysis of hair cross-sections indicated an increase in the intensity of bonds such as S=O, C=O, cystine, C–N and C–H in APCPs-treated hHFs. Additionally, APCPs elevated the expression of Keratin 17, integral to the inner root sheaths (IRS) and outer root sheaths (ORS), as well as Keratins 31, 85, and 86, components of the hair cortex and medulla. APCPs treatment also resulted in increased bonded water and moisture content in hHFs, along with a reduction in cuticle surface roughness. These findings suggest that APCPs may have the potential to enhance hair elasticity and gloss.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106534"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of walnut shell extract on lipid metabolism and serum metabolomics in rats with high-fat diet-induced obesity","authors":"Xu Zhang ,&nbsp;Yan Luo ,&nbsp;Li Qin ,&nbsp;Yage Ma ,&nbsp;Dan Chen ,&nbsp;Shenglan Zhao","doi":"10.1016/j.jff.2024.106558","DOIUrl":"10.1016/j.jff.2024.106558","url":null,"abstract":"<div><div>Rich in flavonoids and phenolic compounds, walnut shells have lipid-lowering, antioxidant, and anti-inflammatory properties; however, their impact on blood lipids has not been widely documented. We investigated the effects of walnut shell extract (WSE) on the lipid metabolism and serum metabolomics of rats with obesity. The results showed that WSE reduced the body weight and serum TC、TG and LDL-c levels and increased the HDL-c levels in obese rats (<em>p</em> &lt; <em>0.05</em>). It also decreased the activities of liver enzymes (ALT and AST), and modulated the levels of major lipid metabolism markers, downregulating LEP and FAS and upregulating ADP, PPAR-γ, and HSL. Additionally, serum metabolomic profiling was used to identify 29 differential metabolites, four of which were most significantly correlated with glycolipid metabolism. These results suggest that the potential mechanism of action of WSE in the treatment of hyperlipidemia is related to its regulatory effects on glycolipid metabolic pathways.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106558"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galangin alleviates alcoholic liver disease by regulating the gut-liver axis","authors":"Dongzhu Duan,&nbsp;Zhenzhen Du,&nbsp;Ling Zhao","doi":"10.1016/j.jff.2024.106506","DOIUrl":"10.1016/j.jff.2024.106506","url":null,"abstract":"<div><div>The imbalance of gut microbiota ecology caused by alcohol consumption disrupts the gut-liver axis, leading to the occurrence and progression of alcoholic liver disease (ALD). This study investigates the effects of galangin (GA) on the gut-liver axis in an alcohol-induced mouse model of ALD, focusing on its potential to regulate gut microbiota composition, intestinal permeability, and hepatic inflammation. The results showed that GA intervention alleviated liver oxidative stress injury and inflammation, improved gut microbiota imbalance, regulated intestinal permeability by up-regulating the expression of tight junction proteins, and enhanced intestinal barrier function. GA treatment reduced liver oxidative stress and inflammation rectified, alcohol-induced dysbiosis, and bolstered the intestinal barrier by up-regulating tight junction proteins. Additionally, the improvement of ALD by GA is mainly related to the Metabolism of xenobiotics by cytochrome P450 and Glutathione metabolism pathways. These results suggest that GA may alleviate ALD by regulating abnormalities of the gut-liver axis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106506"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The therapeutic perspective of cinnamon (Cinnamomum verum) consumption against metabolic syndrome","authors":"Tehmina Bibi ,&nbsp;Ammar B. Altemimi ,&nbsp;Roshina Rabail ,&nbsp;Seemal Munir ,&nbsp;Muhammad Umar Shahbaz ,&nbsp;Maryam Khalid Rizvi ,&nbsp;Muhammad Faisal Manzoor ,&nbsp;Gholamreza Abdi ,&nbsp;Ahsan Ul Haq ,&nbsp;Rana Muhammad Aadil","doi":"10.1016/j.jff.2024.106545","DOIUrl":"10.1016/j.jff.2024.106545","url":null,"abstract":"<div><div>Metabolic syndrome (MetS)<!--> <!-->is one of the most significant worldwide public health issues. Hypertension, visceral obesity, hyperglycemia, dyslipidemia, and insulin resistance are some of the contributing variables. The latest MetS preventative measures have focused on lifestyle factors and combination therapy, including exercise and herbal treatment. Cinnamon <em>(Cinnamomum verum)</em> is rich in phytochemicals, including phenolic and volatile compounds, responsible for its antitumor, anticancer, antidiabetic, and anti-hypertriglyceridemia potentials. Numerous clinical studies have demonstrated the value of cinnamon’s anti-inflammatory properties in treating diabetes. Cinnamon is crucial in maintaining normal levels of lipids in the blood. In the past ten years, several clinical studies have examined the effectiveness of cinnamon administration in managing inflammation-related diseases,<!--> <!-->metabolic abnormalities, and polycystic ovarian syndrome. Comprehensive information about the chemical composition, nutritional compounds, phytoconstituents, and protective role of cinnamon and cinnamaldehyde against metabolic syndrome has been presented in this review. An effort has also been made to explain the mechanisms of blood glucose management, visceral obesity management, and cinnamon safety and toxicity aspects.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106545"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of walnut supplementation in managing overweight and obesity: A meta-analysis of randomized clinical trials","authors":"Wen Liu ,&nbsp;Enqiang Li ,&nbsp;Mingdong Hu","doi":"10.1016/j.jff.2024.106515","DOIUrl":"10.1016/j.jff.2024.106515","url":null,"abstract":"<div><div>This study aimed to assess how effective walnut supplementation is in managing overweight and obesity. A thorough search of PubMed, Embase, and Cochrane Central Register of Controlled Trials was carried out until March 2024. Two reviewers independently examined the suitability of studies and assessed the quality of reporting in the randomized controlled trials (RCTs) that were included. The results indicated that adding walnuts to the diet significantly lowered total cholesterol (TC) levels (<em>p &lt; 0.0001</em>) and low-density lipoprotein-cholesterol (LDL-C) levels (<em>p &lt; 0.001</em>). However, there was no notable difference in weight loss (<em>p &gt; 0.05</em>) and body mass index (BMI) (<em>p &gt; 0.05</em>) between those who received walnut supplementation and the control groups. Based on the RCT data, it appears that walnut supplementation can effectively decrease TC and LDL-C levels. Additionally, it seems to be a safe choice for individuals who are overweight or obese, as it did not have an adverse effect on body weight.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106515"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-proliferation effect of chitooligosaccharide on colitis-associated cancer in mice: Possible involvement of miRNA-155/TLR4/Reg3g pathway","authors":"Xiwei Liu ,&nbsp;Yichao Ma ,&nbsp;Jie Guo,&nbsp;Jun Wang","doi":"10.1016/j.jff.2024.106560","DOIUrl":"10.1016/j.jff.2024.106560","url":null,"abstract":"<div><div>Chronic colonic inflammation might result in increased cell proliferation that poses risk of colitis-associated cancer(CAC), an aggressive subtype of colorectal cancer. This study aimed to investigate dietary intervention effect and mechanism of chitooligosaccharide(COS) on azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced CAC development in mice. COS at dose of 500 mg/kg markedly suppressed colonic levels of tumor necrosis factor(TNF)-α, interleukin(IL)-1β, and IL-6 in CAC mice. Compared to CAC model controls, the number of colonic epithelial cells expressing Ki-67 and the colonic expression levels of cyclin D1 were decreased in COS-treated CAC mice. COS administration significantly down-regulated expression of micro(mi)RNA-155, toll-like receptor(TLR)4, nuclear factor-kappaB(NF-κB), phosphorylated signal transducer and activator of transcription protein 3(pSTAT3), and regenerating islet derived 3 gamma(Reg3g), whereas up-regulated the suppressors of cytokine signaling 1 (SOCS1) expression in CAC colons. Overall, COS exerted protective activity against AOM/DSS-induced colitis-associated carcinogenesis, mechanism of which was associated with its anti-proliferation effect possible <em>via</em> regulating miRNA-155/TLR4/Reg3g pathway.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106560"},"PeriodicalIF":3.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142656459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}