Cultivated Cordyceps militaris exerts anti-allergic effects in a cockroach-induced allergic dermatitis mouse model by suppressing inflammation and enhancing epidermal homeostasis

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-06-04 DOI:10.1016/j.jff.2025.106925

Mey-Fann Lee , Jane-Yii Wu , Chi-Sheng Wu , Ming-Hao Lee , Yu-Wen Chu

{"title":"Cultivated Cordyceps militaris exerts anti-allergic effects in a cockroach-induced allergic dermatitis mouse model by suppressing inflammation and enhancing epidermal homeostasis","authors":"Mey-Fann Lee , Jane-Yii Wu , Chi-Sheng Wu , Ming-Hao Lee , Yu-Wen Chu","doi":"10.1016/j.jff.2025.106925","DOIUrl":null,"url":null,"abstract":"<div><div>The study evaluated the anti-allergic effects of ethanol extract derived from laboratory-cultivated <em>Cordyceps militaris (ECM)</em> using the HaCaT cells and cockroach allergen Per a 2-induced allergic dermatitis mouse model. The results indicated that oral administration of ECM significantly reduced serum IgE levels, decreased secretion of Th2-type and proinflammatory cytokines in splenocytes, improved scratch bouts, mitigated epidermal infiltration, and reduced mRNA expression of Thymic Stromal Lymphopoietin (<em>TSLP</em>) and <em>IL-33</em> in skin lesions in the allergen-sensitized mice. The RNA sequencing analysis of skin lesions revealed the aryl hydrocarbon receptor repressor (<em>AHRR</em>) gene downregulated, enhancing epidermal homeostasis and mediating skin barrier function. Our findings provide evidence for the application of oral ECM in atopic dermatitis and various allergic dermatitis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106925"},"PeriodicalIF":3.8000,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Functional Foods","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756464625002671","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The study evaluated the anti-allergic effects of ethanol extract derived from laboratory-cultivated Cordyceps militaris (ECM) using the HaCaT cells and cockroach allergen Per a 2-induced allergic dermatitis mouse model. The results indicated that oral administration of ECM significantly reduced serum IgE levels, decreased secretion of Th2-type and proinflammatory cytokines in splenocytes, improved scratch bouts, mitigated epidermal infiltration, and reduced mRNA expression of Thymic Stromal Lymphopoietin (TSLP) and IL-33 in skin lesions in the allergen-sensitized mice. The RNA sequencing analysis of skin lesions revealed the aryl hydrocarbon receptor repressor (AHRR) gene downregulated, enhancing epidermal homeostasis and mediating skin barrier function. Our findings provide evidence for the application of oral ECM in atopic dermatitis and various allergic dermatitis.

Abstract Image

查看原文本刊更多论文

培养的蛹虫草通过抑制炎症和增强表皮稳态，在蟑螂诱导的过敏性皮炎小鼠模型中发挥抗过敏作用

本研究利用HaCaT细胞和蟑螂过敏原对2致变应性皮炎小鼠模型的抗过敏作用进行了评价。结果表明，口服ECM可显著降低变应原致敏小鼠血清IgE水平，降低脾细胞中th2型和促炎细胞因子的分泌，改善抓伤，减轻表皮浸润，降低胸腺基质淋巴生成素（TSLP）和IL-33在皮损处的mRNA表达。通过对皮肤病变的RNA测序分析，发现芳烃受体抑制因子（AHRR）基因下调，增强表皮稳态，介导皮肤屏障功能。本研究结果为口服ECM治疗特应性皮炎和各种变应性皮炎提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.