Journal of Functional Foods最新文献

{"title":"Antidepressant and neuroprotective potential of stingless bee honey in a preclinical stress model","authors":"Anish Ameera Shaheran ,&nbsp;Nurfatihah Azlyna Ahmad Suhaimi ,&nbsp;Wan Amir Nizam Wan Ahmad ,&nbsp;Shazana Hilda Shamsuddin ,&nbsp;Jafri Malin Abdullah ,&nbsp;Mohd Zulkifli Mustafa","doi":"10.1016/j.jff.2025.106913","DOIUrl":"10.1016/j.jff.2025.106913","url":null,"abstract":"<div><div>Stingless bee honey (SBH), as a functional food supplement, is of particular interest in this context due to its potential to modulate neurobiological factors such as BDNF and neurotransmitter release, which are often disrupted in depressive disorders. SBH is a fermented honey rich in trehalulose, probiotics, organic acids including aliphatic acids, and various bioactive compounds. These properties mitigate neurodegenerative processes by reducing oxidative stress and inflammation, enhancing neuronal resilience, and supporting the maintenance of cognitive function and overall brain health. This preclinical study aims to investigate the antidepressant effects of SBH in the chronic restrained stress (CRS) depression model via behavioural, hormone secretions, and histological analyses. Forty-two Swiss Albino mice (8 weeks old) were divided into five groups, receiving SBH supplementation or paroxetine (positive control). CRS was induced for 2 h daily for 28 days. The evaluated effects include body weight, behavioural tests, neurotransmitter levels, hippocampal neuron integrity, and brain-derived neurotrophic factor (BDNF) expression. The results of the physicochemical analysis confirmed that the SBH complied with the Malaysian Standard (MS2683:2017). FESEM experiment indicates the presence of bacteria and yeast on the walls of cerumen pots. Behavioural assessments demonstrated a significant reduction in anxiety-like behaviours and immobility duration among SBH-treated groups, indicative of its anxiolytic and antidepressant-like effects. The biochemical evaluations via ELISA assay showed that SBH supplementation reduced corticosterone levels, maintained serotonin concentrations, and increased dopamine availability, whilst elevating the serum phenylalanine levels. Upregulated BDNF expression and downregulation of the pro-inflammatory cytokines were also observed. The increased level of BDNF has been closely linked with synaptic plasticity as well as regulating the monoaminergic neurotransmitter regulation. These findings underscore the potential of SBH as a neuroprotective supplement, likely mediated by monoamine modulation, neurogenesis, and anti-inflammatory effects, warranting further clinical investigations as a functional food with anti-depressant effects.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106913"},"PeriodicalIF":3.8,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The extracts of small-leaved kudingcha as potential modulators of β-cells for the therapy of type 2 diabetes mellitus","authors":"MingJuan Chen ,&nbsp;Lirong Huang ,&nbsp;Qinqin Xiong ,&nbsp;Ningning Zan ,&nbsp;Zhi Wang ,&nbsp;Yongfen Bai ,&nbsp;Jia Yu ,&nbsp;Sha Cheng ,&nbsp;Hong Zeng ,&nbsp;Mashaal Ahmad ,&nbsp;Heng Luo","doi":"10.1016/j.jff.2025.106922","DOIUrl":"10.1016/j.jff.2025.106922","url":null,"abstract":"<div><div>Small-leaved Kudingcha (SLK), a unique variety of tea, has blood sugar-lowering effect. However, the underlying molecular mechanisms of lowering blood sugar is still unclear. Here, the crude extract of SLK and its four fractions of petroleum ether (SLK-PE), ethyl acetate (SLK-EA), n-butanol (SLK-NA), and water (SLK-WA) were prepared and analyzed by Liquid Chromatography-Mass spectrometry/Mass spectrometry. The findings revealed that SLK-PE and SLK-NA ameliorated polydipsia, polyphagia, and polyuria in T2DM mice, as well as serum biochemical indicators. We found that SLK-PE and SLK-NA could enhance blood sugar regulation ability and improve the degree of islet cells damage by upregulating the relative protein levels of p-PI3K/PI3K and p-AKT/AKT ratios, as well as Glut4, Nrf2, INS, SIRT1 and PGC-1α, while downregulating the expression levels of Keap-1, FoXO1, GSK3β, and GCG. Cellular experiment results further demonstrated that SLK-PE and SLK-NA could promote MIN6 cells proliferation and increasing insulin secretion via PI3K/AKT signaling pathway. Additionally, SLK-PE and SLK-NA have a high level of safety. The findings demonstrate that SLK-PE and SLK-NA could serve as potential functional additives for the prophylaxis and management of diabetes and linked metabolic conditions.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106922"},"PeriodicalIF":3.8,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional and health promoting properties of traditional regional foods: Harnessing omics techniques for microbial and metabolite identification","authors":"Sonal Aggarwal,&nbsp;Deepika Kathuria,&nbsp;Narpinder Singh","doi":"10.1016/j.jff.2025.106919","DOIUrl":"10.1016/j.jff.2025.106919","url":null,"abstract":"<div><div>Traditional food is an integral part of cultural heritage and identity for indigenous peoples' worldwide. It reflects a rich tapestry of flavours, textures, and nutritional benefits that resonate both locally and globally. Traditional foods encapsulate centuries-old culinary practices and embody a profound connection to local ecosystems, climates, and cultural heritage. Asia, with its vast geographical area and cultural diversity, boasts a particularly diverse regional cuisine. Historically, citizens were unaware of the health benefits of their traditional regional foods, but scientific advancements have illuminated these advantages, leading to global promotion of local cuisines, for example, toddy and shalgam or India origin delivered anti-tumor properties and were heart-friendly foods; various pickles (through the globe) contributed to reducing serum cholesterol, were heart-nurturing and improved digestion; jamu kunir asem (Indonesia) aided in curing respiratory disorders and shown antiviral activities; gilaburu juice (Turkey) relieved renal disorders, respiratory disorders, and hypertension; and kimchi (Korea) prohibited tumor formation and possessed anti-hyperglycemic activity. From fermented pickles to probiotic-rich dairy products, traditional foods were shown provide an array of bioactive compounds and nutrients contributing to overall well-being. Furthermore, the integration of meta-omics tools enables researchers to unravel the secrets of traditional fermentation processes, ensuring both safety and authenticity while navigating the delicate balance between cultural authenticity and contemporary dietary needs. This article explores various traditional foods from different regions across the globe, their metabolites, and associated health benefits</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106919"},"PeriodicalIF":3.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Effect of astaxanthin- and tocotrienol-containing foods on the ocular function of healthy individuals: A randomized, placebo-controlled, double-blind, parallel-group trial” [J. Funct. Foods 122 (2024) 106456]","authors":"Takahiro Sekikawa ,&nbsp;Yuki Kizawa ,&nbsp;Yanmei Li ,&nbsp;Naoki Miura","doi":"10.1016/j.jff.2025.106917","DOIUrl":"10.1016/j.jff.2025.106917","url":null,"abstract":"","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106917"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intake of high-purity dietary fiber from Okara to prevent intestinal damage caused by acute ulcerative colitis","authors":"Wang Yi ,&nbsp;Zhang Ruining ,&nbsp;An Bohan ,&nbsp;Huang Xiaolong ,&nbsp;Fu Hongling ,&nbsp;Gao Junjie ,&nbsp;Khalid Amin ,&nbsp;Lyu Bo ,&nbsp;Yu Hansong","doi":"10.1016/j.jff.2025.106918","DOIUrl":"10.1016/j.jff.2025.106918","url":null,"abstract":"<div><div>High-purity insoluble dietary fiber (HPIDF) from okara has been proved to improve the colonic environment in case of acute ulcerative colitis (AUC). However, the effect of dietary fiber (DF) daily intake, on prevention and decline of AUC is not clear. In this study we investigated the effect of DF daily intake, on improving the overall colon condition during AUC, by establishing an animal model. A 21 days daily intake plan of HPIDF and low-purity dietary fiber (LPDF) from okara was used, by feeding C57BL/6 mice before induction of AUC. The AUC was induced post 21 days daily intake plan in mice through dextran sulfate sodium (DSS). The levels of inflammatory factors, the colonic internal environment (composition of microorganisms and short-chain fatty acids [SCFASs]), and bioinformatics were analyzed with the colonic tissue status. Results showed that the daily intake of HPIDF can protect against excessive colonic injury, maintain the stability of SCFASs, alleviate the inflammatory response and stabilize microbial structure when AUC occurs. Bioinformatics showed that the changes in the internal environment in the colon were mostly related to the biosynthetic process, such as amino acids, carbohydrates, cell structure, vitamins, lipids and fatty acids. This study demonstrated that daily intake of HPIDF have the potential to prevent excessive colonic injury when AUC occurs, although the hyperplasia of some non-probiotics was also accompanied by this process.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106918"},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of anti-AD active ingredients from Huai yam using surface plasmon resonance technology and mechanistic exploration based on ERβ-harmonized inflammation and autophagy","authors":"Mengnan Zeng ,&nbsp;Kaili Ye ,&nbsp;Yuanyuan Wang ,&nbsp;Fangzhuo Chang ,&nbsp;Bing Cao ,&nbsp;Fengxiao Hao ,&nbsp;Pengli Guo ,&nbsp;Yuhan Zhang ,&nbsp;Ziyu Zhang ,&nbsp;Weisheng Feng ,&nbsp;Xiaoke Zheng","doi":"10.1016/j.jff.2025.106915","DOIUrl":"10.1016/j.jff.2025.106915","url":null,"abstract":"<div><div>Huai yam is a model of “medicinal and edible homology” plants in China that have been used to treat Alzheimer's disease (AD) for a long time. This study prepared the AD model using 5 × FAD transgenic mice, explore the active ingredients and mechanism of Huai yam on AD using surface plasmon resonance (SPR) ligand fishing technology and biological methods, and provide an experimental basis for the clinical treatment of AD. Yam and affinity component (1-methoxycarbonyl-<em>β</em>-carboline) detected by SPR technology improved cognitive ability and neuronal damage, transformed immune cells from peripheral blood, reduced brain inflammation and apoptosis, and upregulated the levels of autophagy via ER<em>β</em>. Moreover, 1-methoxycarbonyl-<em>β</em>-carboline also regulated metabolic disorders in 5 × FAD transgenic mice. These data provide a further pharmacological basis for the clinical application of Huai yam to prevent AD and help to understand the herbal function and “homology of medicine and food”.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106915"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women: A double-blinded randomized clinical trial","authors":"Gu Yuming ,&nbsp;Lu Zhejun ,&nbsp;Sun Longyu ,&nbsp;Zong Chenyu ,&nbsp;Han Qinglin","doi":"10.1016/j.jff.2025.106906","DOIUrl":"10.1016/j.jff.2025.106906","url":null,"abstract":"<div><h3>Background</h3><div>This study evaluated the effects of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women.</div></div><div><h3>Methods</h3><div>In this randomized, double-blind, placebo-controlled trial, 52 postmenopausal women were received synbiotic or placebo for six months. Anthropometric measurements, bone mineral density (BMD), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (P1NP), tartrate-resistant acid phosphatase 5b (TRAP-5b), and bone-specific alkaline phosphatase (BSAP) were assessed.</div></div><div><h3>Results</h3><div>Although there were no considerable differences in BMI, fat mass, or BMD between groups, a significant decrease was observed in the synbiotic group regarding visceral fat content (<em>p</em> = 0.004), TRAP-5b (<em>p</em> &lt; 0.001), BSAP (<em>p</em> = 0.003), and CTX (<em>p</em> = 0.028). No substantial changes were observed in OPG, RANKL, OC, or P1NP (<em>p</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Synbiotic supplementation significantly reduced visceral fat and markers of bone resorption in postmenopausal women.</div><div><strong>Clinical trial registration:</strong> ChiCTR2300076114.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106906"},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation of deep-sea mineral water improves the anti-cancer effects of tomato in colorectal cancer cells","authors":"Okin Abidemi Oluwasanmi ,&nbsp;Sin-il Sin ,&nbsp;Seung-Hwan Park ,&nbsp;Anna Han","doi":"10.1016/j.jff.2025.106914","DOIUrl":"10.1016/j.jff.2025.106914","url":null,"abstract":"<div><div>Tomato (<em>Solanum lycopersicum</em>) is a well-known anti-cancer food; however, the impact of cultivation methods on its anti-cancer effects is unexplored. Deep sea water (DSW) contains high concentrations of various minerals, offering diverse health-positive outcomes. This study compared the anti-cancer effects of tomatoes cultivated conventionally (REG), organically (OG), and organically with DSW supplementation (ODSW). Among all tomato extracts (TEs), ODSW had the highest activities of ABTS, DPPH, total phenolic and flavonoids. All TEs significantly decreased the cell viability, cell migration, and colony formation of HCT116 and Caco2 cells; however, compared to REG and OG, ODSW led to a further decrease of those indicators. Additionally, ODSW suppressed cell cycle regulation proteins (e.g., p-STAT3 and occludin) than REG and OG. Moreover, ODSW produced a high level of pro-apoptotic protein (e.g., Bim) relative to REG and OG. These findings suggest that DSW-supplementation organic cultivation can improve the efficacy of tomatoes' anti-cancer effects in CRC cells.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106914"},"PeriodicalIF":3.8,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotic activity of functional whole mushroom powders in short-term in vitro colonic simulations","authors":"Julie Daoust ,&nbsp;Jay Schmalz ,&nbsp;Lieven Van Meulebroek ,&nbsp;Jonas Ghyselinck ,&nbsp;Lynn Verstrepen ,&nbsp;Massimo Marzorati","doi":"10.1016/j.jff.2025.106912","DOIUrl":"10.1016/j.jff.2025.106912","url":null,"abstract":"<div><div>Minimally processed, whole mushroom powders (Cordyceps [<em>Cordyceps militaris</em>], Reishi [<em>Ganoderma lucidum s.l.</em>], Lion's Mane [<em>Hericium erinaceus</em>], and Turkey Tail [<em>Trametes versicolor</em>]) and blends (GRAS blend, 4 species; MaxSpectrum blend, 10 species) were evaluated for their effects on the human gut microbiota. Short-term in vitro colonic simulations were performed. Metabolic changes, including significant increases in acetate, propionate, and butyrate levels were observed with all test products versus untreated control. Further, beneficial bacteria were enhanced with all test products. Caco-2/THP1 co-culture studies with fermentations from Cordyceps, Reishi, and MaxSpectrum blend colonic simulations demonstrated significant improvement in intestinal barrier function with all test products versus untreated control (fecal donor-dependent). Test product-dependent/donor-dependent pro-inflammatory molecule (TNFα, CXCL10, MCP-1) decreases and anti-inflammatory cytokine (IL-6 and IL-10) increases were observed versus untreated control. Tryptamine levels increased and pyruvic acid levels decreased with these test products versus untreated control. All six mushroom products demonstrated prebiotic properties.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106912"},"PeriodicalIF":3.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational disruption of paired helical filaments (PHFs) assembly using Milk Lactalbumin-derived peptides against Alzheimer's disease","authors":"Saeed Pourmand ,&nbsp;Sara Zareei ,&nbsp;Mohanna Jozi ,&nbsp;Shokoufeh Massahi","doi":"10.1016/j.jff.2025.106853","DOIUrl":"10.1016/j.jff.2025.106853","url":null,"abstract":"<div><div>Peptides show great potential in diagnosing and treating Alzheimer's disease (AD), particularly by targeting amyloid-beta plaques and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau proteins. This study focuses on designing peptide inhibitors from bovine milk alpha-lactalbumin to reduce tau aggregation in AD. Using computational techniques, such as docking, molecular dynamics simulations, and mutagenesis, we evaluated the binding and stability of these peptides against the paired helical filament (PHF) core. Our results identified promising inhibitors, with p136 emerging as the most effective. It significantly altered the PHF core's structure, preventing further aggregation by blocking additional subunits. Additionally, p76 displayed strong binding against straight filaments (SFs). These findings highlight the potential of peptides derived from bovine milk alpha-lactalbumin as diagnostic and therapeutic tools for AD, with p136 standing out as a promising candidate for disrupting tau aggregation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"130 ","pages":"Article 106853"},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}