Journal of Functional Foods最新文献

{"title":"Enhanced immunomodulatory properties of ovalbumin through transglutaminase and tyrosinase/caffeic acid-catalyzed crosslinking plus galactomannan conjugation alleviates allergic asthma","authors":"Ishfaq Ahmed ,&nbsp;Pei Mao ,&nbsp;Chuang Ouyang ,&nbsp;Caimei Song ,&nbsp;Qinghui Ai ,&nbsp;Yanyan Wang ,&nbsp;Gonghua Huang","doi":"10.1016/j.jff.2024.106536","DOIUrl":"10.1016/j.jff.2024.106536","url":null,"abstract":"<div><div>Ovalbumin (OVA) is the primary allergenic protein, associated with T helper 2 (Th2)-mediated allergy reactions. Here, we studied OVA’s conformational structure, digestibility, and allergenic potency upon galactomannan (Man) conjugation along with transglutaminase-catalyzed crosslinking (TG-Man/OVA) and tyrosinase/caffeic acid-catalyzed crosslinking (Tyr-Man/OVA). Enzymatic glycosylation altered OVA’s conformation and enhanced the gastrointestinal digestibility. Stimulation of bone marrow-derived dendritic cells (BMDCs) with enzymatically glycosylated OVA reduced the expression of CD40, CD80, CD86 and MHC class II molecules. Furthermore, glycosylated OVA increased IL-10 production while suppressing proinflammatory cytokine production in BMDCs. In an OVA-induced mouse asthma model, TG-Man/OVA and Tyr-Man/OVA upregulated IFN-γ and IL-10 expression and downregulated IL-4, IL-5, and IL-13 in lungs. Crosslinked OVA diminished infiltrated cells in bronchoalveolar lavage fluid and lung and attenuated eosinophilic airway inflammation. These findings offer valuable insights into the development of a novel product with improved hypoallergenic and immunomodulatory properties and hold promise in attenuating allergic diseases.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106536"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coeloglossum viride var. bracteatum attenuates lipopolysaccharide-induced acute depressive-like behaviors in mice by inhibiting neuroinflammation and protecting synaptic plasticity","authors":"Zhe Guo ,&nbsp;Jinpeng Bai ,&nbsp;Jun Wang ,&nbsp;Xiuyuan Lang ,&nbsp;Min-Min Cao ,&nbsp;Si-Jia Zhong ,&nbsp;Liang Cui ,&nbsp;Yang Hu ,&nbsp;Xiao-Yan Qin ,&nbsp;Rongfeng Lan","doi":"10.1016/j.jff.2024.106526","DOIUrl":"10.1016/j.jff.2024.106526","url":null,"abstract":"<div><div>Microglia-mediated neuroinflammation and synaptic damage contribute to the pathogenesis of major depressive disorder. <em>Coeloglossum viride</em> var. <em>bracteatum</em> extract (CE) has anti-inflammatory and neuroprotective effects. Therefore, we hypothesized that CE could inhibit the pathogenesis of depression. To test this hypothesis, we evaluated the antidepressant effects of CE in a lipopolysaccharide (LPS)-induced mouse model. We showed that CE ameliorated LPS-induced depressive-like phenotypes such as increased preference for sucrose, decreased immobility, and improved willingness to move in mice. Consistently, CE reduced the levels of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 in the brain. Mechanistically, CE transformed the phenotypic polarization of microglia by inhibiting the enhancement of aerobic glycolysis and improving oxidative phosphorylation, mediated by the HIF-1α/PKM2 signaling axis. CE reversed the reduction in synaptic proteins, dendritic spines, and neuronal loss. Thus, CE may alleviate LPS-induced depression through anti-inflammation, alteration of microglial energy metabolism and protection of synaptic plasticity, thus highlighting its potential as antidepressant.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106526"},"PeriodicalIF":3.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artemisia argyi polysaccharide ameliorates hyperglycemia through modulating gut microbiota and serum metabolism in type 2 diabetic mice","authors":"Qiaoying Song,&nbsp;Hankui Wu,&nbsp;Shaoting Weng,&nbsp;Yao Wang,&nbsp;Lingqi Kong,&nbsp;Ziqing Liu,&nbsp;Kunpeng Zhang","doi":"10.1016/j.jff.2024.106525","DOIUrl":"10.1016/j.jff.2024.106525","url":null,"abstract":"<div><div>In this manuscript, we investigated the hypoglycemic effect and mechanism of <em>Artemisia argyi</em> polysaccharide (ALP-1) on high-fat diet/streptozotocin-induced diabetes mice. After 4 weeks of oral administration of ALP-1, the HALP-1 diabetic mice group showed a 27.2 % reduction in liver index, a 10.3 % decrease in fasting blood glucose, and a 14.19 % decrease in glycated serum protein compared to the DM group. Additionally, improvements were observed in oxidative stress, inflammatory response, and serum insulin levels. Furthermore, the HALP-1 group exhibited enhanced glucose tolerance, liver glycogen level, and insulin sensitivity. Moreover, ALP-1 could increase the abundance of SCFAs, especially n-butyric acid in intestinal contents and faeces of diabetes mice. Intestinal flora results showed that ALP-1 treatment increased the abundance of genus <em>Allobaculum</em> in the cecum of diabetic mice. The results of fecal microbiota transplantation and antibiotics treatment confirmed that ALP-1 exerts hypoglycemic effect through regulating intestinal flora to a certain extent. The findings of our investigation indicate that ALP-1 has the potential of ameliorate hyperglycemia through modulating gut microbiota and serum metabolism.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106525"},"PeriodicalIF":3.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Spirulina platensis microalgae on renal function and antioxidant defence in rats with streptozotocin-induced diabetes","authors":"Amani A. Alrasheedi,&nbsp;Alaa I. Basnawi,&nbsp;Maha A. Althaiban","doi":"10.1016/j.jff.2024.106485","DOIUrl":"10.1016/j.jff.2024.106485","url":null,"abstract":"<div><h3>Background</h3><div><em>Spirulina platensis microalgae</em> (SPM), a natural antioxidant, is among the marine algae-containing compounds that are postulated to possess an anti-diabetic effect. This research aimed to assess the potential effect of SPM solution on blood glucose levels, kidney functions, and antioxidant defences in rats with diabetes induced by streptozotocin (STZ).</div></div><div><h3>Methodology</h3><div>Forty adult male Albino Wister rats were equally distributed into five groups. Group (1) included rats that were treated as a negative control group, the remaining groups included rats that were administrated STZ via injections to induce diabetes which were then treated for four weeks with the following scheme: group (2) diabetic positive control rats; groups (3,4 and 5) diabetic rats received oral SPM (400 ml/kg/day), Glimepiride (GI) (600 µg/kg/day); and SPM (400 ml/kg/day) + GI (600 µg/kg/day) respectively. On the final day of the experiment, blood samples were collected to estimate the blood glucose level, and kidney function parameters in addition to tumour necrosis factor-α (TNF-α), Interleukins (IL-1α), and (IL-6). Histopathological examination was done for the kidneys.</div></div><div><h3>Results</h3><div>SPM and/ or GI administration significantly reduced blood glucose levels, Glycated haemoglobin HbA1c, kidney function parameters, TNF-α, IL-1α, IL-6 in diabetic rats, and elevated insulin levels compared to the positive control group (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The hypoglycemic effect of Spirulina has been shown in rats with diabetes caused by STZ. This suggests that Spirulina could potentially serve as a novel therapeutic approach for managing diabetes and its associated consequences. The availability, efficacy, and cost-effectiveness of Spirulina further support its potential as a viable treatment option.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106485"},"PeriodicalIF":3.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of hydroalcoholic extract of Fumaria parviflora Lam on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes: A randomized controlled clinical trial","authors":"Arash Karimi ,&nbsp;Elham Dalir Abdollahinia ,&nbsp;Saeed Ostadrahimi ,&nbsp;Mahdi Vajdi ,&nbsp;Majid Mobasseri ,&nbsp;Amir Bahrami ,&nbsp;Helda Tutunchi ,&nbsp;Farzad Najafipour","doi":"10.1016/j.jff.2024.106528","DOIUrl":"10.1016/j.jff.2024.106528","url":null,"abstract":"<div><div>The present study examined the effects of hydroalcoholic extract of <em>Fumaria parviflora</em> (FP) on gene expression and serum levels of inflammatory and oxidative stress parameters in patients with type 2 diabetes. A total of 70 overweight or obese patients with diabetes were randomly assigned to either a FP (500 mg/day) or a placebo (cornstarch 500 mg/day) group for eight weeks. At the endpoint, mRNA expression levels of the B cell lymphoma-2 (BCL-2) and nuclear factor erythroid 2–related factor 2 (Nrf-2) were significantly higher in the FP group compared to placebo. In comparison, expression levels of the Bcl-2-associated protein x (BAX), nuclear factor kappa B (NF-κB), and monocyte chemoattractant protein-1 (MCP-1) were significantly lower in the FP group. FP supplementation resulted in a significant reduction in serum levels of intercellular adhesion molecule-1 (ICAM), interleukin-6, tumor necrosis factor-alpha, and malondialdehyde, as well as an increase in serum levels of antioxidant parameters.</div><div><strong>Trial registration:</strong> Iranian Registry of Clinical Trials (IRCT), IRCT20130610013612N11, <span><span>https://irct.behdasht.gov.ir/trial/58544</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106528"},"PeriodicalIF":3.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Milk fat globule membrane attenuates acute Salmonella typhimurium infection induced mouse model of colitis and ameliorates intestinal immunity","authors":"Xiao Xiao ,&nbsp;Chen Ding ,&nbsp;Qianxu Wang ,&nbsp;Jiarui Zhao ,&nbsp;Qinyuan Bao ,&nbsp;Bingkun Bao ,&nbsp;Mengge Zhao ,&nbsp;Caroline Richard ,&nbsp;Zhigang Liu ,&nbsp;Yongbo She","doi":"10.1016/j.jff.2024.106533","DOIUrl":"10.1016/j.jff.2024.106533","url":null,"abstract":"<div><div>Research investigating the effects of milk fat globule membranes (MFGM) on <em>Salmonella typhimurium</em>-induced colitis, intestinal barrier integrity, and gut-associated immune responses remains scarce. This study aimed to investigate the potential of dietary MFGM to alleviate <em>S. typhimurium</em>-induced colitis in mice. Male C57BL/6J mice were administered <em>S. typhimurium</em> to induce colitis and were then subjected to dietary interventions with either bovine MFGM (BMFGM) or goat MFGM (GMFGM). Both BMFGM and GMFGM mitigated <em>S. typhimurium</em>-induced colitis, as evidenced by increased body weight, decreased mRNA levels of pro-inflammatory cytokines (TNF-α, IFN-γ, IL-1β, and IL-6) in the colon, reduced intestinal permeability, and increased mRNA expression of tight junction-associated genes (Claudin-1 and ZO-1). Additionally, there was a reduction in the number of <em>S. typhimurium</em> in the mesenteric lymph nodes and an improvement in CD4 T cell activation status. Furthermore, liver and spleen injury was reduced, and serum levels of pro-inflammatory cytokines (IFN-γ, IL-1β, IL-4, IL-2, IL-6, and TNF-α) were decreased by both type of MFGM. Overall, BMFGM and GMFGM effectively alleviated <em>S. typhimurium</em>-induced colitis and associated hepatic and splenic injuries.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106533"},"PeriodicalIF":3.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The memory-improving effect of Hizikia forsiforme functional oil microcapsule (HFFOM) prepared by subcritical extraction and complex coacervational embedding","authors":"Yanmei Li ,&nbsp;Longjian Zhou ,&nbsp;Qiuyu Xia ,&nbsp;Yingying Nie ,&nbsp;Zeyuan Ma ,&nbsp;Yayue Liu ,&nbsp;Zhiyou Yang ,&nbsp;Pengzhi Hong ,&nbsp;Yi Zhang","doi":"10.1016/j.jff.2024.106532","DOIUrl":"10.1016/j.jff.2024.106532","url":null,"abstract":"<div><div>Functional foods are prospective in improving memory decline caused by Alzheimer’s disease and aging. The Edible seaweed <em>Hizikia fusiforme</em> functional oil (HFFO) inhibited acetylcholinesterase, prevented cellular neuroinflammation, and improved memory deficits in zebrafish models in the previous studies. To realize its greener preparation and lipid oxidation mitigation and study its effects on higher animals, more investigations are necessary. Herein, sub-critical fluid extraction of HFFO and successive complex coacervation embedding yielded a water-soluble and anti-oxidative microcapsule HFFOM, which displayed in vivo memory-improving effects on LPS-injured zebrafish and normal rodents in different behavior tests. HFFOM can elevate the level of the neurotransmitter acetylcholine while decreasing the levels of MDA, IL-1β, and TNF-α in the zebrafish brain. LC-MS/MS and lipidomic analysis suggested its predominant memory-improving ingredients to be linolenic, erucic, nervonic, arachidonic, linoleic, eicosatrienoic, docosahexaenoic, and docosapentaenoic acids. This study enlightens the potential of HFFOM in developing memory-enhancing functional foods or drugs.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106532"},"PeriodicalIF":3.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Co-supplementation with alpha-linolenic acid and L-carnitine on inflammatory status and oxidative stress in women with migraine: A randomized, triple-blind, placebo-controlled trial","authors":"Sahar Golpour-hamedani ,&nbsp;Mohammad Bagherniya ,&nbsp;Fariborz Khorvash ,&nbsp;Awat Feizi ,&nbsp;Manoj Sharma ,&nbsp;Gholamreza Askari","doi":"10.1016/j.jff.2024.106496","DOIUrl":"10.1016/j.jff.2024.106496","url":null,"abstract":"<div><div>Migraine is associated with inflammation and oxidative imbalance. This randomized controlled trial examined the effects of alpha-linolenic acid (ALA) and L-carnitine co-supplementation on inflammatory status and oxidative stress in 80 women with migraine. Serum markers were measured before and after the intervention. Compared to placebo, ALA and L-carnitine co-supplementation significantly reduced nitric oxide (−6.10; 95 % CI (−9.08, −3.12) vs. 1.77; 95 % CI (−3.21, 6.76) nmol/mL, P = 0.038), malondialdehyde (−5.47; 95 % CI (−6.33, −4.62) vs. −0.15; 95 % CI (−0.50, −0.20) nmol/mL, P = 0.011), and C-reactive protein (−0.44; 95 % CI (−0.47, −0.41) vs. −0.02; 95 % CI (−0.05, 0.007) mg/L, P = 0.007) levels. It also increased total antioxidant capacity (185.60; 95 % CI (159.69, 211.50) vs. 5.22; 95 % CI (−29.21, 39.66) nmol/mL, P = 0.045) and superoxide dismutase activity (301.42; 95 % CI (230.63, 372.21) vs. 15.20; 95 % CI (−8.15, 38.55) U/mL, P = 0.009), suggesting potential benefits for migraine management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106496"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combretum micranthum G. Don (Combretaceae): Its physiological effects on hydro-electrolyte metabolism, renal tubular function and blood pressure","authors":"Maïmouna Touré ,&nbsp;Serge Manga ,&nbsp;Mouhamadou A. Sakho ,&nbsp;Alioune D. Fall ,&nbsp;Sidy M. Seck","doi":"10.1016/j.jff.2024.106511","DOIUrl":"10.1016/j.jff.2024.106511","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Hydro-electrolyte balance is necessary to maintain body homeostasis and blood pressure values within narrow limits. This is accomplished, in part, by renal responses. We conducted this study to determine the effects of &lt;em&gt;Combretum micranthum&lt;/em&gt; on hydro-electrolyte metabolism, renal function and arterial blood pressure.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Subjects and methods&lt;/h3&gt;&lt;div&gt;We conducted a pilot study including 40 subjects: 10 control subjects, 10 subjects under &lt;em&gt;Combretum micranthum G. Don&lt;/em&gt; (400 mg/day), 10 subjects under furosemide (120 mg/day), and 10 subjects under spironolactone (50 mg/day).&lt;/div&gt;&lt;div&gt;Anthropobiometric, cardiovascular parameters and the body composition were collected from each subject. Blood and 24-hour urine samples were collected for biological tests.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;At baseline, clinical and biological parameters were comparable for all groups. Consumers of &lt;em&gt;combretum micranthum&lt;/em&gt; had a significant decrease in global body fat percentage (−1.63 %; p = 0.045). In the group of &lt;em&gt;combretum micranthum&lt;/em&gt; consumers, the body water mass (BWM) is significantly evolved in the direction of an increase (4.37; p = 0.023) and similar to what was observed in the group of subjects treated with spironolactone (0.67; p = 0.042). Consumption of &lt;em&gt;combretum micranthum&lt;/em&gt; showed a marked reduction in hypertension indices (systolic blood pressure, diastolic blood pressure and heart rate) identical to that induced by consumption of furosemide or spironolactone. The consumption of &lt;em&gt;combretum micranthum&lt;/em&gt; resulted in a significant reduction in kaliemia (−1.07; p &lt; 0.0001) and without any notable effect on natremia (p = 0.119) and chloremia (p = 0.708). In contrast, furosemide and spironolactone caused a significant decrease in natremia (respectivly, −0.80; p = 0.022 and −0.50; p = 0.009). In the &lt;em&gt;combretum micrathum&lt;/em&gt; group, the kaliuresis and the chloruresis were significantly increased (respectively, 373.9; p = 0.005 and 441.3; p = 0.028), interestingly, we found a remarkable decrease in natriuresis (−193.3; p = 0.074). In the group of furosemide consumers, the kaliuresis and the chloruresis were significantly increased (respectively, 380.24; p = 0.013 and 425.5; p = 0.013), but with a tendency to increase natriuresis. In the group of subjects taking spironolactone, the urinary concentrations of the three electrolytes studied (natriuresis, kaliuresis and chloruresis) was increased significantly (respectively, 357.5; p = 0.037 and 222.5; p = 0.005 and 563.4; p = 0.007).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Combretum micranthum&lt;/em&gt; would have constituents involved in the maintenance of hydro-electrolyte homeostasis and in the regulation of blood pressure through the involvement of several mechanisms, especially at the renal level. These actions would be attributable to its polyphenolic components. A broader study is needed to better understand the physio","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106511"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mulberry galacto-oligosaccharides ameliorates non-alcoholic fatty liver disease in mice induced by a high-fat diet","authors":"Erna Li,&nbsp;Xinru Chen,&nbsp;Sentai Liao,&nbsp;Daorui Pang,&nbsp;Qian Li,&nbsp;Yuxiao Zou","doi":"10.1016/j.jff.2024.106522","DOIUrl":"10.1016/j.jff.2024.106522","url":null,"abstract":"<div><div>A type of oligosaccharide named mulberry galacto-oligosaccharides (MGO), was isolated from mulberry with a galactose-only, weighs 987 Da and displays diverse biological properties. The objective of this work was to investigate the protective effects of MGO in non-alcoholic fatty liver disease (NAFLD) mice. The results showed that MGO can reduce the body weight and liver weight of NAFLD mice, and reduce the levels of NEFA, TG, TC and LDL-C in serum and liver as well as the activities of AST and ALT. Increase HDL-C content, SOD, and GSH activity in serum and improve pathological damage. MGO regulates the AMPK lipid metabolism pathway, upregulates the expression of ATGL, downregulates the expression of SREBP-1, inhibits lipogenesis, and promotes lipolysis. MGO alleviates liver function damage in NAFLD mice, improves blood lipids, liver metabolism, and increases the body’s antioxidant capacity, suggesting MGO potential as a dietary supplement and functional food to combat HFD-induced NAFLD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106522"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}