Journal of Functional Foods最新文献

{"title":"Lactobacillus helveticus GCL1815 induces salivary IgA production and alleviates common cold-like symptoms: A randomized, double-blind, placebo-controlled, parallel-group comparative study","authors":"Kaoru Kikuchi ,&nbsp;Hiroka Wada ,&nbsp;Yasuo Saito ,&nbsp;Taisuke Uesugi ,&nbsp;Kazuma Takahashi ,&nbsp;Naoki Azuma ,&nbsp;Takashi Mawatari ,&nbsp;Kana Nishimura ,&nbsp;Yoshitaka Iwama","doi":"10.1016/j.jff.2025.106815","DOIUrl":"10.1016/j.jff.2025.106815","url":null,"abstract":"<div><div><em>Lactobacillus helveticus</em> GCL1815 has been shown to suppress cold-like subjective symptoms and activate dendritic cells in prior clinical studies. This randomized, double-blind, placebo-controlled, parallel-group study was conducted to determine the effects of low or high doses of GCL1815 on physical condition and immune indices. In this study, a low-dose group of 6 × 10⁹ GCL1815 cells/day and a high-dose group of 1 × 10¹¹ GCL1815 cells/day were compared to a placebo group. A cold-like symptom questionnaire was established as the primary endpoint of the study. Both the low-dose and high-dose groups showed significant improvement in several systemic and local cold-like symptoms after 8 weeks of GCL1815 intake. This intervention was also found to enhance salivary sIgA secretion rate. No safety concerns were observed even in the high-dose group. These results suggest continuous intake of heat-sterilized GCL1815 for 8 weeks promoted sIgA secretion and reduced systemic and local cold-like symptoms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106815"},"PeriodicalIF":3.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the colostrum-containing multi-nutrient dietary supplement on immune, muscle, bone, and cognitive function parameters in the elderly: A randomized, double-blind, placebo-controlled trial","authors":"Nahathai Dukaew ,&nbsp;Preeyaporn Klinjan ,&nbsp;Ratchanon Inpan ,&nbsp;Mingkwan Na Takuathung ,&nbsp;Supat Jiranusornkul ,&nbsp;Siripat Chaichit ,&nbsp;Weerakit Taychaworaditsakul ,&nbsp;Jakkrit Aisara ,&nbsp;Wichaya Karat ,&nbsp;Nut Koonrungsesomboon","doi":"10.1016/j.jff.2025.106816","DOIUrl":"10.1016/j.jff.2025.106816","url":null,"abstract":"<div><div>Aging leads to declines in immune function, muscle mass, bone density, and cognition. This 12-week randomized, double-blind, placebo-controlled study evaluated the effects of a colostrum-based dietary supplement (COL) in 80 participants aged 55–70 years. Primary outcomes included immune and inflammatory markers, while secondary outcomes assessed serum insulin-like growth factor (IGF)-1 levels, body composition values, bone turnover markers, cognitive function, and safety. The COL group showed significant increases in stool bovine IgG (MD = 2.75 μg/mL, <em>p</em> &lt; 0.0001) and serum IGF-1 (MD = 10.30 ng/mL, <em>p</em> = 0.005), with trends toward higher serum human IgG and anti-inflammatory cytokine IL-10 levels. Other parameters showed no significant changes. COL supplementation was well-tolerated, with no severe adverse events. These findings suggest that COL enhances immune resilience and supports anabolic processes, highlighting its potential to promote healthy aging and improve the quality of life in elderly individuals.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106816"},"PeriodicalIF":3.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic analysis of the Otoprotective effects of green tea extract on age-related hearing loss","authors":"Changye Li ,&nbsp;Xiaolin Zhang ,&nbsp;Jinjin Zhang ,&nbsp;Ruijuan Cao ,&nbsp;Peixia Hao ,&nbsp;Weichen Wang ,&nbsp;Xuehua Liu ,&nbsp;Cuijie Shao ,&nbsp;Xiuzhen Liu ,&nbsp;Yanfei Wang ,&nbsp;Ruyi Zhang ,&nbsp;Qing Yin Zheng","doi":"10.1016/j.jff.2025.106779","DOIUrl":"10.1016/j.jff.2025.106779","url":null,"abstract":"<div><div>Background: Age-related hearing loss (ARHL) is a very common complex disease that causes hearing deficits with age. ARHL seriously affects the cognition and quality of life for the elderly. An ideal method of treating or preventing ARHL is currently unavailable. Green tea and its active ingredients can reduce the risk of age-related diseases.</div><div>Objective: This study aimed to evaluate the effect of green tea and its important active ingredients such as epigallocatechin gallate (EGCG) on ARHL, as well as to reveal the molecular mechanism underlying this effect.</div><div>Methods: Green tea extract (GTE) along with EGCG was given to C57BL/6 J mice over a period of 9 months. The dosage of green tea extract used in this study corresponds to a human acceptable intake level and is within the known safety range. The impact on hearing was measured using the auditory brainstem response. Subsequently, 4D label-free proteomics was utilized to examine the expression of cochlear proteins in the GTE and 12 m groups. Differential protein expression was visualized through volcano plot analysis. Enrichment evaluations of GO and KEGG pathways were performed to uncover biological roles and molecular pathways. Furthermore, proteins within these differential expressions were analyzed using PPI network and VarElect analysis, enhancing the identification of key proteins based on scoring criteria.</div><div>Results: GTE-treated mice had better hearing than control ones, whereas EGCG-treated mice had no significant improvement in hearing. GTE-treated mice also showed better cochlear tissue morphology, and less spiral ganglion neuron damage than control ones. 4D label-free proteomics were used to assess the proteomic patterns. A multitude of differentially expressed proteins (59) were identified in the cochlea of GTE-treated mice. Pathway analysis further indicated that these DE proteins were involved in the Cytosolic DNA-sensing pathway, spliceosome, Rap1 signaling, and metabolism process of various substances, such as taurine.</div><div>Conclusions<em>:</em> Long-term GTE supplementation ameliorated ARHL in mice through various pathways, suggesting some drug targets for ARHL treatment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106779"},"PeriodicalIF":3.8,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Hibiscus sabdariffa L. on body composition and airway reactivity in obese asthmatic rats","authors":"Sarah Rebeca Dantas Ferreira ,&nbsp;Rayane Fernandes Pessoa ,&nbsp;Alissa Maria de Oliveira Martins ,&nbsp;Indyra Alencar Duarte Figueiredo ,&nbsp;Bárbara Cavalcanti Barros ,&nbsp;José Luiz de Brito Alves ,&nbsp;Adriano Francisco Alves ,&nbsp;Yuri Mangueira do Nascimento ,&nbsp;Luiz Henrique César Vasconcelos ,&nbsp;Fabiana de Andrade Cavalcante","doi":"10.1016/j.jff.2025.106757","DOIUrl":"10.1016/j.jff.2025.106757","url":null,"abstract":"<div><div>Obesity worsens asthma symptoms and reduces treatment response, highlighting the potential of <em>Hibiscus sabdariffa</em> (HS), traditionally used for obesity management, as a treatment for obesity-exacerbated asthma. This study evaluated whether HS could prevent body composition, airway function, and reactivity changes in Wistar rats with obesity-exacerbated asthma. Male rats were divided into control (Ctrl), obese asthmatic (Ob + Asth), and HS-treated groups at 250, 500, and 1000 mg/kg. Rats received a high-glycemic diet for 16 weeks and were sensitized to ovalbumin in the last 22 days. HS was administered orally in the last 30 days. In vivo assessments included weight, fasting glucose, body mass index, and pulmonary ventilation, while in vitro tests measured tracheal contraction and lung and adipose histomorphometry. HS prevented weight gain, reduced glucose and adiposity, decreased adipocyte size, and limited tracheal hyperreactivity and peribronchovascular inflammation. These findings support HS as a promising option for treating obesity-exacerbated asthma.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106757"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary metabolites and antioxidant activity of different parts from the medicinal and edible Alpiniae oxyphylla Miq","authors":"Yajie Xiang ,&nbsp;Wencheng Hou ,&nbsp;Meiran Wang ,&nbsp;Jian Feng ,&nbsp;Wenlan Li ,&nbsp;Yangyang Liu","doi":"10.1016/j.jff.2025.106803","DOIUrl":"10.1016/j.jff.2025.106803","url":null,"abstract":"<div><div><em>Alpinia oxyphylla</em> Miq. is widely used in the production of Chinese medicine and food, and its traditional edible parts are mainly seeds, with less exploitation of the non-medicinal parts shells and leaves, resulting in a serious waste of resources. In this study, four batches of plant materials collected from the main producing areas of <em>A. oxyphylla</em> in China, and the chemical components of seed, shell and leaf from medicinal and non-medicinal parts of them were analyzed by UHPLC-QTRAP-MS/MS, essential oil content (EOC) were determined using water vapor distillation, and the total flavonoids content (TFC), total polyphenols content (TPC), total polysaccharides content (TPSC), and antioxidant activities in vitro were evaluated using UV spectrophotometry, the relationship between chemical components and antioxidant activities were analyzed by canonical correlation analysis. The results showed that a total of 1216 metabolites were identified from the three parts of <em>A. oxyphylla</em>, and only 136 metabolites differed between the traditional non-medicinal and medicinal parts, and the non-medicinal parts was superior to the traditional medicinal parts in terms of TPC, TFC, TPSC and in vitro antioxidant activity, only the EOC was lower than that of the seeds, and the in vitro antioxidant activity of the <em>A. oxyphylla</em> was significantly and positively correlated to the content of TFC and TPC in the metabolites. This study showed that the shells and leaves of the non-medicinal parts of <em>A. oxyphylla</em> also have good prospects for development and application, providing a scientific basis for the comprehensive development and utilization of <em>A. oxyphylla</em>.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106803"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the encapsulation of probiotics as functional foods for colorectal cancer prevention","authors":"Ai Wei Gan ,&nbsp;Xing Kang ,&nbsp;Shermin S. Goh ,&nbsp;Sunny H. Wong ,&nbsp;Say Chye Joachim Loo","doi":"10.1016/j.jff.2025.106804","DOIUrl":"10.1016/j.jff.2025.106804","url":null,"abstract":"<div><div>Probiotics are widely used in food and supplements for their health benefits. Increasing evidence shows that certain strains can help prevent colorectal cancer (CRC). Traditional probiotics have been shown to prevent carcinogenesis <em>via</em> secretion of anti-proliferative metabolites, downregulation of inflammatory or oncogenic pathways, and reduction of cell proliferation, whereas novel bacterial strains may also confer benefits as Next Generation Probiotics (NGPs). However, to deliver these probiotics effectively to the colon, their primary site of action, the microbes must survive through the harsh gastrointestinal environment. Particularly, NGPs are sensitive to oxygen, making it challenging for their practical use. Thus, their protection is of paramount importance. This review discusses the use of traditional probiotics and newly discovered NGPs as functional food for CRC prevention, the current encapsulation techniques and materials used for effective encapsulation of the probiotics, and the challenges and future directions for the development of encapsulated probiotics as functional food.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106804"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammatory biomarkers as mediators of the association between dietary flavonoids and sleep disorders in patients with hypertension: A population-based study","authors":"XiaoJie Wang ,&nbsp;YuanLong Hu ,&nbsp;JiaMing Huan ,&nbsp;Feng Jiang ,&nbsp;LaiYun Xin ,&nbsp;Zhen Hua ,&nbsp;XuPeng Shao ,&nbsp;Hua Zhou ,&nbsp;QiBiao Wu ,&nbsp;YunLun Li","doi":"10.1016/j.jff.2025.106788","DOIUrl":"10.1016/j.jff.2025.106788","url":null,"abstract":"<div><div>Dietary flavonoids are beneficial for the management of chronic diseases. This research aimed to investigate the impact of dietary flavonoid intake on sleep disorders in hypertensive patients and to explore the potential mediating effects of systemic inflammatory biomarkers. The cross-sectional study analyzed data from 4538 noninstitutionalized hypertensive patients with sleep disorders from two survey cycles (2007–2008, 2009–2010) of the National Health and Nutritional Examination Survey. The results showed that hesperetin alleviated sleep disorders in hypertensive patients (OR = 0.86, 95 % CI = 0.76 to 0.97; <em>P</em> = 0.037). Additionally, mediation analyses indicated that inflammatory markers mediated a significant portion of the association between dietary hesperetin intake and the risk of sleep disorders in hypertensive patients: CRP (5.31 %, <em>P</em> = 0.008), PAR (12.29 %, <em>P</em> = 0.016), and CAR (1.34 %, <em>P</em> = 0.008). Hesperetin intake positively contributed to improving sleep disorders in hypertensive patients, and this favorable association was partly mediated through improvements in systemic inflammatory markers.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143815264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of betaine on pulmonary arterial hypertension treatment and mechanisms based on the PERK-eIF2α signal-pathway","authors":"Yuxin Liu ,&nbsp;Ping Ma ,&nbsp;Jinxin Tao ,&nbsp;Zhi Wang ,&nbsp;Zhi Chang ,&nbsp;Qingbin Xu ,&nbsp;Ru Zhou","doi":"10.1016/j.jff.2025.106780","DOIUrl":"10.1016/j.jff.2025.106780","url":null,"abstract":"<div><div>PAH is marked by excessive PASMCs and resistance to apoptosis. ERS drives pulmonary vascular remodeling. Betaine from <em>Lycium barbarum</em> L. protects against PAH, is orally available to humans and shows no obvious toxicity for humans and animals at 100, 200, 400 mg/kg. However, the ERS link remains unexplored. This study investigates betaine's PAH protective mechanisms. SD rats received a single subcutaneous injection of notaline to induce PAH and received betaine and sildenafil avenate for 21 d. Betaine significantly improved abnormal changes in echocardiography, hemodynamics, and pathomorphology. Betaine inhibited the proliferation of HPASMCs induced by PDGF-BB. Moreover, betaine suppressed the protein expression of GRP78 and improved the protein expression of p-PERK in rat lungs. It also significantly upregulated PERK and eIF2α phosphorylation in HPASMCs. Upon PERK siRNA knockdown, betaine restores PERK and eIF2α phosphorylation. Betaine activates PERK-eIF2α, mitigates ERS, and targets PERK, as a potential PAH therapy.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106780"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics with ABCG2 expression ability and gut microbiota homeostasis exhibit anti-hyperuricemia potential by promoting uric acid excretion","authors":"Yuting Fan ,&nbsp;Liuying Li ,&nbsp;Philippe Madjirebaye ,&nbsp;Zhencong Yang ,&nbsp;Xiaoliang Shu ,&nbsp;Xiang Li ,&nbsp;Xuli Wu","doi":"10.1016/j.jff.2025.106814","DOIUrl":"10.1016/j.jff.2025.106814","url":null,"abstract":"<div><div>Probiotics have been reported to have the potential effect of alleviating Hyperuricemia (HUA). However, due to the complexity of its mechanisms, the research on probiotics with anti-HUA potential is still limited. In this study, administration of <em>Lactobacillus rhamnosus</em> HN001, <em>Bifidobacterium lactis</em> HN019, and <em>Lactobacillus acidophilus</em> NCFM exhibited UA-reducing capacity, as well as lowering creatinine and urease levels and xanthine oxidase (XOD) activity. They effectively contribute to a decrease in pro-inflammatory (IL-1<em>β</em> and TNF-<em>α</em>) factors while regulating the expression of transporters, particularly the ATP-binding cassette subfamily G2 (ABCG2). These strains also powerfully restore the gut microbiota, increasing the abundance of the <em>Lactobacillaceae</em>, thus playing a crucial role in HUA reduction by being intensely involved in the expression of ABCG2 transporter. These findings provide a pivotal theoretical basis for elucidating the potential probiotics as dietary supplements to relieve HUA via intestinal remediation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106814"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Sasa borealis on improving andropause symptoms by upregulating testicular steroidogenesis in testosterone deficiency models, in vitro and in vivo","authors":"Jeong Yoon Lee ,&nbsp;Hyo-Kyoung Choi ,&nbsp;Kyung-Chul Choi ,&nbsp;Mina Jo ,&nbsp;Jung-Yoon Yoo ,&nbsp;Yoo-Hyun Lee","doi":"10.1016/j.jff.2025.106783","DOIUrl":"10.1016/j.jff.2025.106783","url":null,"abstract":"<div><div>The purpose of this study was to evaluate the effects of <em>Sasa borealis</em> 30 % ethanol extract (SBE) on andropause. In TM3 Leydig cells, SBE significantly increased testosterone (T) levels lowered by oxidative stress. SBE also increased the mRNA expressions of 3β-HSD, 17β-HSD, and CYP17A1 enzymes, which transform cholesterol into T. Next, for the T-deficient animal models, 23-week-old male Sprague-Dawley (SD) rats were divided into groups of three subjects each: OLD, SB100 (SBE 100 mg/kg BW/day), SB300 (SBE 300 mg/kg BW/day), and YOUNG (7-week-old normal control group). The doses used in this study are within the range of previously reported animal studies using oral administration. The SB300 group showed higher serum T levels compared to the OLD group, while simultaneously enhancing testicular steroidogenesis. The SBE-treated groups showed increased muscle mass, sperm count, and grip strength. Tricin, a phenolic compound in SBE, that significantly increased T production in TM3 cells. We conclude that SBE could improve andropause by increasing the T levels, regulating T synthesis, and alleviating physiological symptoms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"128 ","pages":"Article 106783"},"PeriodicalIF":3.8,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}