Journal of Functional Foods最新文献

{"title":"Ameliorative actions of ginseng flower alcoholic extract, on drug-induced hepatotoxicity: A focus on PI3K/AKT/mTOR signaling modulation and intestinal microbiome homeostasis","authors":"Minqi Jin ,&nbsp;Yibin Xing ,&nbsp;Xin Qi ,&nbsp;Cheng-bi Cui","doi":"10.1016/j.jff.2024.106482","DOIUrl":"10.1016/j.jff.2024.106482","url":null,"abstract":"<div><div>This study focused on examining the effects and mechanism of action of ginseng flower alcohol extract (GFAE) on a drug-induced liver injury (DILI) mice model. Ginseng blossoms were extracted with alcohol and examined for their principal active components using high performance liquid chromatography (HPLC), revealing that GFAE was made up of six ginsenoside active components. By creating a mouse model of DILI and measuring its relevant inflammatory indexes and related proteins, it was revealed that GFAE treats DILI by decreasing inflammatory factors, inhibiting inflammation and hepatocyte apoptosis, suppressing abnormal activation of the Phosphatidylinositol 3-Kinase/Protein Kinase B/Mammalian Rapamycin Target Protein (PI3K/AKT/mTOR) signaling pathway, and increasing beneficial bacteria in the intestinal tract, enhancing intestinal flora diversity, and improving the intestinal environment.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106482"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blueberry anthocyanins regulate SIRT1/FoxO1 pathway to inhibit oxidative stress and reduce testicular tissue damage induced by microwave radiation in rats","authors":"Yueyue Pang ,&nbsp;Junqi Men ,&nbsp;Yanyang Li ,&nbsp;Jing Zhang ,&nbsp;Li Zhao ,&nbsp;Hui Wang ,&nbsp;Haoyu Wang ,&nbsp;Xinping Xu ,&nbsp;Ji Dong ,&nbsp;Congsheng Li ,&nbsp;Ruiyun Peng ,&nbsp;Binwei Yao ,&nbsp;Shuchen Liu","doi":"10.1016/j.jff.2024.106523","DOIUrl":"10.1016/j.jff.2024.106523","url":null,"abstract":"<div><div>Researches have shown that microwave radiation could cause oxidative stress injury in male reproductive system, and blueberry anthocyanins had excellent oxidation resistance. Our study aimed to investigate the protective effect of blueberry anthocyanins (100, 200 and 400 mg/kg/d) on testicular tissue damage in Wistar rats exposed to 2.856 GHz microwave and the optimal dose. We found that blueberry anthocyanins could ameliorate the decrease of sperm motility and sex hormone levels and testicular tissue structure damage caused by microwave radiation, increase SIRT1 expression and decrease FoxO1 expression, increase GSH/GSSG, SOD and inhibit MDA. The LDH, SDH and ATP synthase were increased, and Caspase-3 expression was decreased, and the high-dose of blueberry anthocyanins (400 mg/kg/d) had the best protective effect. These results suggested that blueberry anthocyanins could inhibit oxidative stress injury induced by 2.856 GHz microwave radiation in rat testicular tissue by regulating SIRT1/FoxO1 pathway, enhance energy metabolism and reduce cell apoptosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106523"},"PeriodicalIF":3.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Nigella sativa as a functional food in diabetes and related complications: Insights on molecular, cellular, and metabolic effects","authors":"Habibeh Mashayekhi-Sardoo ,&nbsp;Samaneh Sepahi ,&nbsp;Vafa Baradaran Rahimi ,&nbsp;Vahid Reza Askari","doi":"10.1016/j.jff.2024.106518","DOIUrl":"10.1016/j.jff.2024.106518","url":null,"abstract":"<div><div>Various studies have been conducted on the effect of medicinal plants in the treatment of different diseases, including diabetes. <em>Nigella Sativa (N. sativa)</em> is a plant with edible and medicinal properties that are of interest to scientists in traditional and complementary medicine, and much research has been conducted on this plant. Comprehensive reports are used to investigate the effect of <em>N. sativa in vitro</em>, animal models, and clinical trials in the treatment of diabetic diseases. An online database search was conducted to investigate the potential anti-diabetic effect of <em>N. sativa</em>. The results of various studies indicate that this plant can act as hypoglycemic, and due to antioxidant properties, it can have positive results in reducing blood sugar and glycosylated hemoglobin levels and controlling insulin secretion and glucose homeostasis. The effect of <em>N. sativa</em> in animal models has shown that <em>N. sativa</em> oil can eliminate oxygen-free radical species similar to hydroxyl free radicals and superoxide radical anions. Therefore, in this review study, we intend to address all the therapeutic aspects and effects of the black seed plant in the cellular and animal environment and clinical trial studies for the optimal use of this medicinal plant. In conclusion, the antidiabetic activities of <em>N. sativa</em> are indeed well established. However, in some cases, the molecular modulation underlying these activities remains unknown. <em>N. sativa</em> has been demonstrated to improve blood glucose and insulin levels, mitigate diabetes complications, and stimulate glucose absorption. Its antioxidant function, flavonoid and triterpenoid components, and potency to modulate insulin secretion in pancreatic cells introduced it as a safe medicinal herb for dietary adjuvant with antidiabetic medications. However, it has been declared to a decline in blood lipid profiles, and risk factors for cardiovascular diseases in Type 2 Diabetes patients. Further research must concentrate on patients unresponsive to available anti-diabetic drugs and hyperlipidemia T2D. Thus, further studies into its medicinal effects are recommended.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106518"},"PeriodicalIF":3.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of active substances in pear paste for the treatment of cough in mice using spectrum-effect relationship study","authors":"Min Xu ,&nbsp;Yuhui Yu ,&nbsp;Huixin Xu ,&nbsp;Meiqing Li","doi":"10.1016/j.jff.2024.106491","DOIUrl":"10.1016/j.jff.2024.106491","url":null,"abstract":"<div><div>In this study, the researchers produced a pear paste using typical Dangshan pear fruits. The mechanism that enables the paste to treat cough and related inflammatory responses was systematically investigated using an ammonia-induced mice cough model. The pear paste and its polar extracts relieved cough symptoms, as evidenced by 44.0%, 53.4%, and 47.2% decreases in cough frequency and 21.0%, 43.3%, and 53.4% increases in latent period for pear paste, ethyl acetate extract (EAE) and n-butanol extract (WBE), respectively. In addition, the paste and its polar extracts reduced lung injuries, including alveolar dilatation, alveolar wall damage, and airway thickening. The two polar extracts exhibited anti-inflammatory effects in the airway through the suppression of a Th1 cytokine (IFN-γ, significantly suppressed by 15.49% and 16.33% for EAE and WBE, separately). A spectrum-effect relationship analysis was conducted to identify arbutin, protocatechuic acid, chlorogenic acid and naringin as the primary bioactive substances contributing to the antitussive and anti-inflammatory activities of pear paste.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106491"},"PeriodicalIF":3.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citrus extraction provides neuroprotective effect in optic nerve crush injury mice through P53 signaling pathway","authors":"Changming Yang ,&nbsp;Jie Chen ,&nbsp;Yinjia He ,&nbsp;Xiaojuan Lin ,&nbsp;Rong Zhang ,&nbsp;Haonan Fu ,&nbsp;Xiaodong Liu ,&nbsp;Linqing Miao","doi":"10.1016/j.jff.2024.106517","DOIUrl":"10.1016/j.jff.2024.106517","url":null,"abstract":"<div><div>Optic nerve injury induces the loss of retinal ganglion cells and optic nerve atrophy. Our previous study demonstrated the neuroprotective effects of Citrus in the optic nerve crush (ONC) injury model. To explore the underlying neuroprotective mechanism, we focus on the changes in gene expression profile pre- and post-Citrus treatment in the ONC injury model. The results suggested that the Citrus regulated the chemokine signaling pathway and P53 signaling pathway, etc. Four genes were identified as potential target genes (<em>Melk</em>, <em>Mki67</em>, <em>Ccnb1</em>, and <em>Cenpf</em>). Subsequent qRT-PCR and western blot confirmed that Citrus regulated cell apoptosis and inflammation-related gene expression, and inhibited P53 activation-induced cell death. The present study demonstrated that the neuroprotective effect of Citrus was achieved through the regulation of the P53/BCL-2/BAX pathway and the expression regulation of four critical genes, which provide novel therapeutic targets for the therapy of optic nerve injury.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106517"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The beneficial effects of crocin supplementation on metabolic and genetic parameters in type 2 diabetic patients under metformin treatment: A randomized double-blind controlled clinical trial","authors":"Alireza Mafi ,&nbsp;Bijan Iraj ,&nbsp;Mohammad Hossein Aarabi","doi":"10.1016/j.jff.2024.106507","DOIUrl":"10.1016/j.jff.2024.106507","url":null,"abstract":"<div><h3>Background and objective</h3><div>Since it has been demonstrated that inflammation and oxidative stress (OS) are important<!--> <!-->in the etiology and complexity of type 2 diabetes mellitus (T2DM), antioxidant treatment is recognized as an effective approach for managing the progression of the disease. The current study was conducted to assess the effects of crocin administration on metabolic and genetic indices in T2DM patients who were receiving metformin.</div></div><div><h3>Materials and methods</h3><div>Sixty T2DM patients, receiving metformin, were included in our randomized double-blind placebo-controlled clinical trial. Patients were divided<!--> <!-->into two groups (n = 30) and received either 15 mg/day crocin supplementation or a placebo twice a day for 12 weeks. Fasting blood was obtained at the beginning and end of the intervention to assess glycemic index, lipid content, indicators of inflammation, and OS. Patients’ peripheral blood mononuclear cells (PBMC) were analyzed for gene expression associated with OS and inflammation using real-time polymerase chain reaction (real-time PCR).</div></div><div><h3>Results</h3><div>Crocin intake significantly decreased fasting plasma glucose (P &lt; 0.001), HbA₁c (P = 0.002), serum insulin levels (P = 0.03), and insulin resistance (P &lt; 0.001), while significantly enhanced insulin sensitivity (P &lt; 0.001) compared with the placebo. These improvements were also found to be statistically significant in comparison to the baseline values in the crocin group. Moreover, a significant reduction in triglyceride levels (P = 0.04), VLDL-cholesterol (P = 0.04), high-sensitivity C-reactive protein (P &lt; 0.001), malondialdehyde (P = 0.046), and significant enhancement of plasma glutathione (P = 0.008) were found in the intervention group compared to the placebo group. Additionally, the level of high-sensitivity C-reactive protein in the intervention group decreased compared to baseline while it increased in the placebo group. Crocin significantly lowered TOS (P &lt; 0.05); however, at the end of the trial there was no significant difference<!--> <!-->between the two groups. Eventually, crocin supplementation induced AMP-activated protein kinase (P = 0.002) and glucose transporter type 4 (P = 0.02), while downregulating nuclear factor kappa B gene expression levels (P = 0.04) of PBMC compared to the placebo.</div></div><div><h3>Conclusion</h3><div>Overall, crocin supplementation was demonstrated to have ameliorative effects on glycemic indices as well as cardio-metabolic risk.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106507"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The m6A/METTL3 modifies SATB2 suppresses cell proliferation and migration of laryngeal squamous cell carcinoma through targeting the Warburg effect by inhibition of the Wnt/β-catenin pathway","authors":"Bohuai Cheng ,&nbsp;Tianrun Liu ,&nbsp;Shimin Zhuang ,&nbsp;Liangen Xie ,&nbsp;Feng Pang ,&nbsp;Ziyin Luo ,&nbsp;Zhiwen Xiao","doi":"10.1016/j.jff.2024.106478","DOIUrl":"10.1016/j.jff.2024.106478","url":null,"abstract":"<div><div>This study aimed to explore the specific AT-rich sequence-binding protein 2 (SATB2) regulated Warburg effect of laryngeal squamous cell carcinoma (LSCC) and its possible mechanism of action.</div><div>Bioinformatic and single-cell analyses revealed that SATB2 expression was suppressed in patients with LSCC. In an in vitro model, SATB2 suppressed LSCC cells proliferation and migration. Si-SATB2 promotes LSCC cells proliferation and migration. Additionally, sh-SATB2 promotes LSCC proliferation in a mouse model. SATB2 suppresses Wnt expression in an in vitro model and si-SATB2 induces Wnt expression in an in vitro model. Additionally, sh-SATB2 suppresses Wnt expression in a mouse model. Wnt inhibitors reduce the effects of si-SATB2 or sh-SATB2 on the Warburg effect and cell proliferation in a mouse or in vitro model of LSCC. SATB2 interacts with Wnt proteins to reduce Wnt protein ubiquitination. Methyltransferase-like 3 (METTL3)-mediated m6A modification decreases SATB2 stability in a YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) −dependent manner in an LSCC model.</div><div>The interaction between the active constituents of SATB2 and Wnt1 results in the inhibition of Wnt/β-catenin, thereby affecting the Wnt/β-catenin-mediated Warburg effect. This study demonstrated that METTL3-mediated m6A modification reduces SATB2 stability in a YTHDF1-dependent manner in an LSCC model, with remarkable efficacy in inducing the Warburg effect in an LSCC model.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106478"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicatechin suppresses the expression of C-C motif chemokine ligand 19 and ameliorates periodontitis","authors":"Tomomi Sano ,&nbsp;Meiqun Yuan ,&nbsp;Rongzhi Li ,&nbsp;Atsushi Yasunaga ,&nbsp;Akiko Mizokami ,&nbsp;Yusuke Nakatsu ,&nbsp;Tomoichiro Asano ,&nbsp;Takashi Kanematsu","doi":"10.1016/j.jff.2024.106512","DOIUrl":"10.1016/j.jff.2024.106512","url":null,"abstract":"<div><div>Periodontitis is a prevalent chronic inflammatory disease requiring the development of drug-based therapies. Epicatechin is a major polyphenol in cocoa extract and possesses numerous pharmacological properties. This study aimed to investigate the suppressive effect of epicatechin on C-C motif chemokine ligand 19 (CCL19)-mediated periodontitis using a mouse model. CCL19 expression was high in mouse gingiva with ligature-induced periodontitis. CCL19 expression was increased by lipopolysaccharide stimulation in murine gingival fibroblasts ESK-1 cells, and CCL19 induced the production of tumor necrosis factor alpha and interleukin-1 beta in mouse macrophage-like RAW264.7 cells. Importantly, lipopolysaccharide-enhanced CCL19 expression in ESK-1 cells was significantly suppressed by pretreatment with epicatechin. In addition, epicatechin administration significantly reduced alveolar bone resorption, and expression of <em>Ccl19</em> and proinflammatory cytokines in the inflamed gingiva in high-fat diet-fed mice. These results demonstrate that epicatechin protects against periodontitis by reducing CCL19 levels, which may be a promising countermeasure for periodontitis in clinical practice.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106512"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effect of apigenin on AK23-induced desmoglein3 depletion in HaCaT cell model of pemphigus vulgaris via suppression of p38 MAPK phosphorylation","authors":"Ji-Eun Lee,&nbsp;Young Sook Kim","doi":"10.1016/j.jff.2024.106504","DOIUrl":"10.1016/j.jff.2024.106504","url":null,"abstract":"<div><div>This study aimed to investigate the effect of apigenin, a flavonoid widely distributed in plants, on AK23-induced desmoglein3 (Dsg3) depletion in pemphigus vulgaris (PV) model using HaCaT cells. Dispase-based dissociation assay showed that the number of cell fragments, which increased compared to the control group due to AK23 treatment, dramatically decreased when HaCaT cells were incubated with AK23 and apigenin. The continuous linear fluorescence intensity of Dsg3 between cells was decreased in the AK23 group, but the treatment of apigenin recovered the fluorescent distribution of Dsg3. Moreover, the addition of apigenin up-regulated the Dsg3 protein expression in AK23-treated HaCaT cells. The phosphorylation level of p38 mitogen-activated protein kinase (MAPK) induced by the AK23 was down-regulated by apigenin. In conclusion, apigenin attenuated AK23-mediated Dsg3 depletion by suppressing the p38 pathway in the PV cell model. Therefore, apigenin could be a functional food material for ameliorating PV.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106504"},"PeriodicalIF":3.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bombyx batryticatus extract on hyperglycemia and gut microbiota in diabetic mice induced by streptozotocin and high-fat diet","authors":"Hwa Lee ,&nbsp;Kwang-Hee Son ,&nbsp;Jong-Hoon Kim","doi":"10.1016/j.jff.2024.106495","DOIUrl":"10.1016/j.jff.2024.106495","url":null,"abstract":"<div><div><em>Bombyx batryticatus</em>, commonly known as the stiff silkworm, has various health benefits, including anti-inflammatory, neuroprotective, and anti-diabetic effects. This study is the first to investigate the effects of <em>Bombyx batryticatus</em> extract (BBE) on the gut microbiome community in streptozotocin (STZ)/high-fat diet (HFD)-induced diabetic mice. Diabetic mice were treated with BBE or metformin (MT, as a positive control) for seven weeks. The results showed that both BBE and MT significantly improved glucose tolerance and fasting glucose levels in diabetic mice. Pancreatic insulin content and islet size were increased in both treatment groups compared to the diabetic model (DM) group. Additionally, BBE or MT treatment significantly suppressed hyperlipidemia and hepatic steatosis. Furthermore, gut microbiota analysis showed that BBE treatment reversed the STZ/HFD-induced increase in Firmicutes and decrease in Bacteroidetes, resulting in a normalized Firmicutes/Bacteroidetes ratio. Notably, levels of <em>Bacteroides vulgatus</em> were significantly increased in the BBE-treated group. Additionally, MT treatment increased the abundance of <em>Lactobacillus gasseri</em> and <em>Akkermansia muciniphila</em> in the gut microbiota. BBE demonstrates potential antidiabetic effects by improving glucose metabolism and modulating the gut microbial community in STZ/HFD-induced diabetic mice. These findings suggest that BBE may be a promising natural therapy for managing diabetes and its associated gut microbiota dysbiosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106495"},"PeriodicalIF":3.8,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}