Journal of Functional Foods最新文献_第7页

Alternative protein sources and healthy skeletal muscle aging: A narrative review 替代蛋白质来源与健康骨骼肌衰老：一个叙述性的回顾

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-25 DOI: 10.1016/j.jff.2025.106990

Zhiqiang Dai , Yan Zhao , Yu Ke , Jianhong Huang , Jincheng Zhu , Huiwen Wu , Ying Yang , Huayu Shang , Zhi Xia

引用次数: 0

Heat-inactivated Bifidobacterium longum ZFML006 extends lifespan in Caenorhabditis elegans via MAPK and insulin/IGF-1 signaling pathways 热灭活长双歧杆菌ZFML006通过MAPK和胰岛素/IGF-1信号通路延长秀丽隐杆线虫的寿命

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-25 DOI: 10.1016/j.jff.2025.106992

Ruonan Wang , Yimin Li , Gang Wang , Zihao Zhang , Yingjie Huang , Ran Tuo , Ruomeng Dong , Zhen Li , Xiangfeng Chen , Shuxun Liu , Qing Gu , Ping Li

{"title":"Heat-inactivated Bifidobacterium longum ZFML006 extends lifespan in Caenorhabditis elegans via MAPK and insulin/IGF-1 signaling pathways","authors":"Ruonan Wang , Yimin Li , Gang Wang , Zihao Zhang , Yingjie Huang , Ran Tuo , Ruomeng Dong , Zhen Li , Xiangfeng Chen , Shuxun Liu , Qing Gu , Ping Li","doi":"10.1016/j.jff.2025.106992","DOIUrl":"10.1016/j.jff.2025.106992","url":null,"abstract":"<div><div>The global burden of aging populations and age-related functional decline presents a major public health challenge. Although live <em>Bifidobacterium</em> exhibits anti-aging properties, its strict anaerobic requirements limit its utility, whereas heat-inactivated preparations may offer enhanced stability and functional activity. This study characterized <em>Bifidobacterium longum</em> (<em>B. longum</em>) ZFML006 and systematically evaluated its anti-aging efficacy in <em>Caenorhabditis elegans</em> (<em>C. elegans</em>) using heat-inactivated administration. Treatment resulted in a 30.64 % increase in lifespan, a 15.20 % reduction in fecundity, a 49.92 % decrease in lipofuscin accumulation, a 20.69 % improvement in thermotolerance, a 14.8 % increase in oxidative stress survival, and enhanced motility. Additionally, it led to 10.6 % lower Reactive Oxygen Species (ROS) levels and elevated Catalase (CAT), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GSH-Px) activities. Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR) analysis revealed coordinated downregulation of <em>daf-2</em> and <em>akt-2</em>, accompanied by the upregulation of <em>daf-16</em>, <em>sod-3</em>, <em>pmk-1</em>, <em>nsy-1</em>, <em>skn-1</em>, and <em>sek-1</em>, confirming the modulation of both Insulin/IGF-1 signaling (IIS) and Mitogen-Activated Protein Kinase (MAPK) signaling pathways. These findings establish heat-inactivated ZFML006 as a potent anti-aging intervention by precisely regulating conserved longevity mechanisms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106992"},"PeriodicalIF":4.0,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144902484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of oyster (Crassostrea gigas) supplementation on the function of skeletal muscles in SD rats 牡蛎（长牡蛎）对SD大鼠骨骼肌功能的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-25 DOI: 10.1016/j.jff.2025.106995

Yun Ma , Baojun Sun , Hitomi Maruta , Hiromi Yamashita

引用次数: 0

A fruitful approach to gut health and functionality 一种有益肠道健康和功能的方法

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-22 DOI: 10.1016/j.jff.2025.106989

Paulo Sérgio Loubet Filho , Vitória Helena de Oliveira Teixeira Reis , Patrícia Berilli , Giovanna Monteiro Rodrigues , Áquila Matheus de Souza Oliveira , Gabriela Torres Silva , Elisvânia Freitas dos Santos , Cinthia Baú Betim Cazarin

{"title":"A fruitful approach to gut health and functionality","authors":"Paulo Sérgio Loubet Filho , Vitória Helena de Oliveira Teixeira Reis , Patrícia Berilli , Giovanna Monteiro Rodrigues , Áquila Matheus de Souza Oliveira , Gabriela Torres Silva , Elisvânia Freitas dos Santos , Cinthia Baú Betim Cazarin","doi":"10.1016/j.jff.2025.106989","DOIUrl":"10.1016/j.jff.2025.106989","url":null,"abstract":"<div><div>Fruits are essential for human health due to their bioactive compounds (BC), including dietary fibers, phenolic acids, flavonoids, carotenoids, and vitamins. These compounds offer antioxidant, anti-inflammatory, and gut microbiota-modulating properties, improving intestinal health by enhancing peristalsis, reducing constipation, and strengthening the gut barrier. Polyphenols help prevent oxidative stress, chronic diseases, and gut dysbiosis, while prebiotic fibers and short-chain fatty acids support microbial diversity and immune function. Specific fruits, such as mango, kiwi, berries, and avocado, aid in inflammatory bowel disease management by reducing inflammation, promoting tissue repair, and improving microbiome composition. Fruits also alleviate constipation by retaining stool moisture and enhancing motility. Their role in gut integrity includes modulating microbiota, enhancing tight junction proteins, and reducing oxidative stress. Overall, fruits provide diverse benefits for gastrointestinal health and chronic disease prevention.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106989"},"PeriodicalIF":4.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells 棘色素A抑制人三阴性乳腺癌细胞的上皮-间质转化并诱导DNA损伤介导的细胞死亡

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-21 DOI: 10.1016/j.jff.2025.106993

Soon Yong Park , Mi-So Jeong , Cong So Tran , Jinyoung Lee , Da-Young Eum , Seyeon Jung , Elena A. Vasileva , Seoung Rak Lee , Hyoung Kyu Kim , Natalia P. Mishchenko , Jin Han , Yoo Jin Choi , Si Ho Choi , Hwayoung Yun , Kyu Heo

{"title":"Echinochrome A inhibits epithelial–mesenchymal transition and induces cell death mediated by DNA damage in human triple-negative breast cancer cells","authors":"Soon Yong Park , Mi-So Jeong , Cong So Tran , Jinyoung Lee , Da-Young Eum , Seyeon Jung , Elena A. Vasileva , Seoung Rak Lee , Hyoung Kyu Kim , Natalia P. Mishchenko , Jin Han , Yoo Jin Choi , Si Ho Choi , Hwayoung Yun , Kyu Heo","doi":"10.1016/j.jff.2025.106993","DOIUrl":"10.1016/j.jff.2025.106993","url":null,"abstract":"<div><div>Echinochrome A (Ech A), a marine-derived compound from <em>Scaphechinus mirabilis</em>, is known for its potent antioxidant activity. Its pharmacological derivative, Histochrome, is used to treat ischemia and cardiovascular disorders. Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis and limited treatment options. This study explores the anticancer effects of Ech A on TNBC cells. Ech A showed dose-dependent cytotoxicity, resulting in 65–75 % cell death in BT549, SUM149, and SUM159 after 72 h of treatment at 50 μM, while no viability changes in MCF10A. At lower concentrations, Ech A suppressed TNBC cell migration and invasion by 60–80 %, along with downregulation of EMT markers Snail and Claudin-1. At higher doses, Ech A induced cell death via DNA damage. These results suggest that Ech A may serve as a promising therapeutic agent for TNBC by targeting metastatic potential and/or cell viability.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106993"},"PeriodicalIF":4.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144880110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirulina maxima extract enhances immune function via NF-κB and MAPK pathways and ameliorates cyclophosphamide-induced immunosuppression and intestinal damage in mice 螺旋藻提取物通过NF-κB和MAPK途径增强免疫功能，改善环磷酰胺诱导的小鼠免疫抑制和肠道损伤

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-19 DOI: 10.1016/j.jff.2025.106987

Hae-Sun Park , Sung-Min Kim , Jong-Yeon Kim , Woon-Yong Choi , Eun-Jung Park , Hae-Jeung Lee

{"title":"Spirulina maxima extract enhances immune function via NF-κB and MAPK pathways and ameliorates cyclophosphamide-induced immunosuppression and intestinal damage in mice","authors":"Hae-Sun Park , Sung-Min Kim , Jong-Yeon Kim , Woon-Yong Choi , Eun-Jung Park , Hae-Jeung Lee","doi":"10.1016/j.jff.2025.106987","DOIUrl":"10.1016/j.jff.2025.106987","url":null,"abstract":"<div><div><em>Spirulina maxima</em> is a filamentous cyanobacterium known for its antioxidant and anti-inflammatory properties. However, its immune-enhancing mechanisms remains largely unknown. In this study, we investigated the immune-enhancing effects of <em>S. maxima</em> 70 % ethanol extract (SM) and its underlying mechanisms using RAW 264.7 macrophages and cyclophosphamide-induced immunosuppression mouse model. Additionally, the protective effects of SM against cyclophosphamide induced intestinal mucosal barrier damage were evaluated. In RAW 264.7 cells, SM increased phagocytic activity, nitric oxide production, and cytokine gene expression via activation of the NF-κB and MAPK signaling pathways. In a mouse model, oral administration of SM increased natural killer cell activity and the serum levels of immunoglobulins and cytokines. In addition, SM alleviated intestinal mucosal damage and increased the expression of tight junction genes. These findings suggest that SM has potential as a multifunctional agent for immune modulation and intestinal health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106987"},"PeriodicalIF":4.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the effects and mechanisms of astaxanthin, astaxanthin esters and astacene on high-fat diet-induced NAFLD 虾青素、虾青素酯和虾青素对高脂肪饮食诱导的NAFLD的作用及机制比较

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-18 DOI: 10.1016/j.jff.2025.106985

Chunhao Gao , Fangtian Chen , Nengyun Gong , Shiran Hu , Mengjia Zhu , Qingxin Zhou , Xiang Gao

{"title":"Comparison of the effects and mechanisms of astaxanthin, astaxanthin esters and astacene on high-fat diet-induced NAFLD","authors":"Chunhao Gao , Fangtian Chen , Nengyun Gong , Shiran Hu , Mengjia Zhu , Qingxin Zhou , Xiang Gao","doi":"10.1016/j.jff.2025.106985","DOIUrl":"10.1016/j.jff.2025.106985","url":null,"abstract":"<div><div>Non-alcoholic fatty liver disease (NAFLD) represents a global health challenge with limited therapeutic options. This study compared the efficacy and mechanisms of astaxanthin (AX), astaxanthin esters (AXE), and astacene (AC) in ameliorating high-fat diet-induced NAFLD in mice. The three supplements improved liver function, and reduced hepatic lipid accumulation, liver injury, serum lipid levels, HOMA-IR index in NAFLD mice. Notably, AXE exhibited slightly better trends. Mechanistically, they activated the hepatic Nrf2/Keap1 antioxidant pathway. Gut microbiota analysis suggested that improvements in gut microbiota dysbiosis might partly elucidate their protective mechanisms on NAFLD, with AC exhibiting superior efficacy. Moreover, transcriptome sequencing analysis indicated that AX primarily regulates gene transcription in adipose tissue and AC exhibited the most potent regulatory impact on gene transcription in liver. While AXE displayed notable efficacy in modulating transcriptional profiles across both tissues. This study provides novel insights into the effects of astaxanthin derivatives in ameliorating NAFLD</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106985"},"PeriodicalIF":4.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of anti-inflammatory properties of neutral lipids, glycolipids, and phospholipids from Oncorhynchus mykiss eggs in LPS-stimulated macrophages 巨噬细胞中中性脂、糖脂和磷脂抗炎特性的评价

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-18 DOI: 10.1016/j.jff.2025.106975

Weerawan Rod-In , Ha Jun Lee , Sang-min Lee , Seok Kyu Jung , Woo Jung Park

{"title":"Evaluation of anti-inflammatory properties of neutral lipids, glycolipids, and phospholipids from Oncorhynchus mykiss eggs in LPS-stimulated macrophages","authors":"Weerawan Rod-In , Ha Jun Lee , Sang-min Lee , Seok Kyu Jung , Woo Jung Park","doi":"10.1016/j.jff.2025.106975","DOIUrl":"10.1016/j.jff.2025.106975","url":null,"abstract":"<div><div>The current study evaluated the anti-inflammatory activity of fractionized lipids obtained from <em>Oncorhynchus mykiss</em> eggs, including neutral lipids (OM-NL), glycolipids (OM-GL), and phospholipids (OM-PL). The fatty acid (FA) content of OM-NL and OM-GL revealed that PUFAs constitute a predominant portion of total FAs, accounting for 41.80 % and 40.96 %, respectively. However, OM-PL showed a higher content of MUFAs, which comprised 42.52 % of the total FAs. The fractionized lipids reduced the dose-dependency production of NO and <em>iNOS</em> expression in LPS-induced RAW264.7 cells. Subsequently, they reduced the transcript levels of <em>TNF-α</em>, <em>IL-1β</em>, and <em>IL-6,</em> and produced <em>TGF</em>-<em>β</em> and <em>IL-10</em> expression, by inhibiting the phosphorylation of proteins involved in inflammatory responses within NF-κB and MAPK pathways. All lipids reduced the levels of PGE<sub>2</sub>, LTB<sub>4</sub>, and EETs by suppressing COX-1, COX-2, 5-LOX, and CYP4A11 proteins, which are involved in eicosanoid synthesis. Thus, our findings demonstrate that the fractionized lipids isolated from <em>O. mykiss</em> eggs have potential anti-inflammatory activity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106975"},"PeriodicalIF":4.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the effects of different ratios of Citrus limon, Citrus sinensis, and Vitis vinifera extracts on insulin resistance in HepG2 cells 研究柠檬、柑橘和葡萄提取物不同配比对HepG2细胞胰岛素抵抗的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-16 DOI: 10.1016/j.jff.2025.106984

M. Pierdomenico , M. Telesca , C. Riccioni , E. Tordi , I. Sagrafena , B. Benassi

{"title":"Investigating the effects of different ratios of Citrus limon, Citrus sinensis, and Vitis vinifera extracts on insulin resistance in HepG2 cells","authors":"M. Pierdomenico , M. Telesca , C. Riccioni , E. Tordi , I. Sagrafena , B. Benassi","doi":"10.1016/j.jff.2025.106984","DOIUrl":"10.1016/j.jff.2025.106984","url":null,"abstract":"<div><div>This study aimed to investigate the molecular mechanisms by which Lemotrin™, a nutraceutical formulation based on <em>Citrus limon</em> (L.) Osbeck, <em>Citrus sinensis</em> (L.) Osbeck, and <em>Vitis vinifera</em> L. extracts, improves insulin resistance in an <em>in vitro</em> model of insulin-resistant human liver cells (HepG2/IR). Three different blends of these plant extracts (Mix1, Mix2 and Mix3) were tested to evaluate their efficacy. The cellular cytotoxicity of each formulation was first assessed. The hypoglycemic effect of each blend was analyzed by measuring glucose uptake, intracellular glycogen content, and the modulation of IRS1 and pro-inflammatory cytokines expression. Mix 1 and Mix 2 of Lemotrin™ significantly increased glucose uptake and intracellular glycogen content, enhanced IRS1 expression and reduced its inhibitory phosphorylated form at Serine 307. TNF-α and IL6 were reduced following treatment with Lemotrin™. Our findings suggest that Lemotrin™ is a promising nutraceutical candidate for the prevention and management of insulin resistance-related conditions.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106984"},"PeriodicalIF":4.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synbiotic regulation of chronic intestinal inflammation by Sargassum horneri fucoidan and Lactobacillus plantarum 马尾藻褐藻聚糖和植物乳杆菌对慢性肠道炎症的合成调节

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2025-08-11 DOI: 10.1016/j.jff.2025.106988

N.M. Liyanage , D.P. Nagahawatta , Fengqi Yang , Young-Sang Kim , Daekyung Kim , You-Jin Jeon

{"title":"Synbiotic regulation of chronic intestinal inflammation by Sargassum horneri fucoidan and Lactobacillus plantarum","authors":"N.M. Liyanage , D.P. Nagahawatta , Fengqi Yang , Young-Sang Kim , Daekyung Kim , You-Jin Jeon","doi":"10.1016/j.jff.2025.106988","DOIUrl":"10.1016/j.jff.2025.106988","url":null,"abstract":"<div><div>Severe inflammation in the intestinal tract is a hallmark of Inflammatory Bowel Disease (IBD). The present study explores the synbiotic potential of bloom seaweed <em>Sargassum horneri</em> fucoidan with <em>Lactobacillus plantarum</em> in preventing intestinal inflammation. Six fucoidan fractions were isolated via DEAE anion exchange chromatography, with SHF6 showing the highest sulfate and fucose content and significantly promoting <em>L. plantarum</em> growth. Synbiotic treatment of SHF6 and <em>L. plantarum</em> on 3 % DSS-induced HT-29 cells significantly improved cell viability, downregulated pro-inflammatory cytokines (IL-6, IL-8, TNF-α, IL-12, IL-1β), downregulated NF-κB/IL6/STAT3 pathway protein expression, and restored tight junction protein expression. In DSS-induced zebrafish larvae, the synbiotic treatment improved healthy intestinal lysosome number and improved mucin production. qPCR analysis showed decreased IL-1β, IL-6, TNF-α, and iNOS gene expressions and increased mucin 2 expression. These findings indicated that SHF6 and <em>L. plantarum</em> exhibit synergistic anti-inflammatory effects, highlighting their potential as a promising therapy for intestinal inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"133 ","pages":"Article 106988"},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144827030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0