Journal of Functional Foods最新文献_第8页

Immunoglobulin-derived peptide MEANP1 of human Milk in the protection against experimental necrotizing Enterocolitis via IκB/ NF-κB pathway 人乳免疫球蛋白衍生肽MEANP1通过i -κB / NF-κB途径对实验性坏死性小肠结肠炎的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106826

Shuwen Yao , Min Zhang , Qinlei Yu , Liping Xu , Xiangyun Yan , Wenjuan Chen , Chengyao Jiang , Yanjie Chen , Kedi Xi , Yu Dai , Shushu Li , Shuping Han , Xiaohui Chen

{"title":"Immunoglobulin-derived peptide MEANP1 of human Milk in the protection against experimental necrotizing Enterocolitis via IκB/ NF-κB pathway","authors":"Shuwen Yao , Min Zhang , Qinlei Yu , Liping Xu , Xiangyun Yan , Wenjuan Chen , Chengyao Jiang , Yanjie Chen , Kedi Xi , Yu Dai , Shushu Li , Shuping Han , Xiaohui Chen","doi":"10.1016/j.jff.2025.106826","DOIUrl":"10.1016/j.jff.2025.106826","url":null,"abstract":"<div><div>Necrotizing enterocolitis (NEC) is one of the most common intestinal emergencies in newborn infants. It is closely related to abnormal activation of intestinal inflammation and impaired barrier function. Studies have shown that breast milk exosomes can effectively improve NEC, but the specific mechanism remains unclear. Human breast milk exosomal cargoes are emerging as new modulators for NEC. To evaluate the function and potential mechanisms of action of peptide MEANP1 both in vivo and in vitro. MEANP1 was found to improve the survival rate, abdominal distension and hematochezia in NEC models. Intestinal histological damage was improved, along with decreased expression of pro-inflammatory factors and increased expression of intestinal barrier protein. In IEC-6 cells, MEANP1 can improve LPS-induced inhibition of proliferation, migration and barrier damage. The pro-inflammatory factors TLR4, TNF-α and IL-1β were inhibited by MEANP1. We verified by RNA-seq technique and rescue experiment that it can inhibit the phosphorylation of NF-κB by inhibiting the phosphorylation of IκBα to protect from NEC. MEANP1 is expected to be a treatment for NEC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106826"},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of rosemary leaf powder on disease symptoms, inflammatory and oxidative markers in patients with rheumatoid arthritis: A double-blinded randomized controlled clinical trial 迷迭香叶粉对类风湿关节炎患者疾病症状、炎症和氧化标志物的影响：一项双盲随机对照临床试验

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106878

MohammadHadi Bayat , Naheed Aryaeian , Fatemeh Shirani , Jamileh Abolghasemi , Azadeh Heydarian , Soudabeh Fallah , Sepideh Barzin Tond , Ehsan Karimi

{"title":"The effect of rosemary leaf powder on disease symptoms, inflammatory and oxidative markers in patients with rheumatoid arthritis: A double-blinded randomized controlled clinical trial","authors":"MohammadHadi Bayat , Naheed Aryaeian , Fatemeh Shirani , Jamileh Abolghasemi , Azadeh Heydarian , Soudabeh Fallah , Sepideh Barzin Tond , Ehsan Karimi","doi":"10.1016/j.jff.2025.106878","DOIUrl":"10.1016/j.jff.2025.106878","url":null,"abstract":"<div><div>In this randomized controlled double-blind clinical trial, 72 patients with rheumatoid arthritis were randomly assigned to two groups: one receiving rosemary leaf powder (4 g/day) and the other receiving a placebo (starch powder, 4 g/day). After 12 weeks of consuming rosemary leaf powder, significant changes were observed in disease activity score (DAS-28), tender joint count (TJC), swollen joint count (SJC), visual analog scale (VAS), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total antioxidant capacity, and malondialdehyde (MDA) between two groups (<em>p</em> ≤ .001). Furthermore, there was no significant difference in morning stiffness (<em>p</em> = .660), patient global assessment (PGA) (<em>p</em> = .056), or tumor necrosis factor-alpha (<em>p</em> = .751) serum levels between the two groups. However, in the group receiving rosemary powder, PGA and TNF-α serum levels decreased significantly (respectively, <em>p</em> = .001, <em>p</em> = .005). In patients with rheumatoid arthritis, rosemary supplements, when used alongside standard medications, may have beneficial effects.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106878"},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of polysaccharides from Spirulina platensis against ultraviolet light-induced skin photoaging in KM mice and damage to mouse dermal fibroblasts 螺旋藻多糖对紫外光诱导KM小鼠皮肤光老化及对小鼠真皮成纤维细胞损伤的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106909

Bingchen Han , Shaobing Wang , Yanfeng Zeng , Youqing Wang , Xiaobo Zeng , Ziyi Yang , Xianju Huang , Shanshan Huang , Haiying Wang , Ruixi Gao , Jun Li

引用次数: 0

Potential of genistein for the treatment of allergic diseases 染料木素治疗过敏性疾病的潜力

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106894

Yaobin Pang , Xueer Zhang , E. Liu , Wenquan Li , Dan Song , Lijun Wang , Jing Guo , JinHao Zeng

{"title":"Potential of genistein for the treatment of allergic diseases","authors":"Yaobin Pang , Xueer Zhang , E. Liu , Wenquan Li , Dan Song , Lijun Wang , Jing Guo , JinHao Zeng","doi":"10.1016/j.jff.2025.106894","DOIUrl":"10.1016/j.jff.2025.106894","url":null,"abstract":"<div><div>Allergic diseases are prevalent health issues, affecting approximately 20 % of the global population. Mast cells (MC) play a pivotal role in allergic reactions by releasing various proinflammatory mediators such as histamine, lipid mediators, and cytokines/chemokines. Natural compounds, particularly secondary plant metabolites, are gaining attention for their potential in disease prevention and treatment. This review focuses on the anti-inflammatory properties of genistein, a naturally occurring isoflavone, in the context of MCs-mediated allergic reactions. Studies demonstrate that genistein effectively inhibits MCs degranulation, reduces the synthesis of arachidonic acid metabolites, and suppresses the expression of cytokines and chemokines. Additionally, genistein modulates the activation of signaling molecules involved in proinflammatory pathways. Clinical trials have also highlighted the beneficial effects of genistein in patients with allergic conditions. While further research is needed to fully establish genistein's efficacy in allergy treatment, the existing evidence suggests its potential as an anti-inflammatory nutraceutical. Addressing the challenges related to genistein's bioavailability could enhance its therapeutic applications.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106894"},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional activities of French raw-milk cheeses on aging, mobility, muscle integrity, and chondrocyte protection using in vivo and in vitro models 利用体内和体外模型研究法国生牛奶奶酪对衰老、运动、肌肉完整性和软骨细胞保护的功能活性

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106899

Anna Diet , Christophe Poix , Muriel Bonnet , Christian Coelho , Isabelle Ripoche , Yohann Wittrant , Caroline Decombat , Julien Priam , Etienne Saunier , Pierre Chalard , Florence Caldefie-Chézet , Stéphanie Bornes , Laurent Rios

{"title":"Functional activities of French raw-milk cheeses on aging, mobility, muscle integrity, and chondrocyte protection using in vivo and in vitro models","authors":"Anna Diet , Christophe Poix , Muriel Bonnet , Christian Coelho , Isabelle Ripoche , Yohann Wittrant , Caroline Decombat , Julien Priam , Etienne Saunier , Pierre Chalard , Florence Caldefie-Chézet , Stéphanie Bornes , Laurent Rios","doi":"10.1016/j.jff.2025.106899","DOIUrl":"10.1016/j.jff.2025.106899","url":null,"abstract":"<div><div>Aging is associated with various musculoskeletal disorders (muscle and/or cartilage disorders) that can decrease both mobility and overall health span. This study investigated the biological activity of seven french raw-milk cheeses on longevity, mobility, muscle integrity during aging, and chondrocyte protection over time using both <em>in vivo</em> (<em>Caenorhabditis elegans</em>) and <em>in vitro</em> (human articular chondrocytes) models. All cheeses enhanced both longevity and mobility during aging in <em>C. elegans</em>. They all protected the muscle integrity of <em>C. elegans</em> over time. The investigations <em>in vitro</em> on an osteoarthritic model of chondrocytes were conducted with fractions (one polar and one apolar) from two cheeses. Among the four tested fractions, we observed a reduction of NO, PGE<sub>2</sub> and MMP-13 productions in the chondrocytes. These findings highlight the biological activity of apolar fraction (containing the cheese lipid components) and suggest, re-evaluating cheese as a functional food with potential benefits for mobility and aging.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106899"},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory effects of Lactiplantibacillus plantarum on the absorption of short chain fatty acids by intestinal epithelial Caco-2 cells 植物乳杆菌对肠上皮Caco-2细胞对短链脂肪酸吸收的调节作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-19 DOI: 10.1016/j.jff.2025.106896

Haiyan Xu , Zihan Xia , Yi Jiang , Feifei Shen , Yue Cheng , Chenchen Zhang , Chengran Guan , Hengxian Qu , Wenlong Ma , Yujun Huang , Ruixia Gu , Dawei Chen

{"title":"Regulatory effects of Lactiplantibacillus plantarum on the absorption of short chain fatty acids by intestinal epithelial Caco-2 cells","authors":"Haiyan Xu , Zihan Xia , Yi Jiang , Feifei Shen , Yue Cheng , Chenchen Zhang , Chengran Guan , Hengxian Qu , Wenlong Ma , Yujun Huang , Ruixia Gu , Dawei Chen","doi":"10.1016/j.jff.2025.106896","DOIUrl":"10.1016/j.jff.2025.106896","url":null,"abstract":"<div><div>Short-chain fatty acids (SCFAs) are beneficial metabolites of intestinal microbiota. The regulation of <em>Lactiplantibacillus plantarum</em> on the uptake of SCFAs (acetic, propionic, and butyric acids) and their transporters by intestinal epithelial Caco-2 cells were investigated. Results indicated that the absorption of SCFAs by cells was significantly increased by <em>L. plantarum</em> f2, f28, and f5 (<em>P</em> < 0.05); but there are significant differences between <em>L</em>. <em>plantarum</em> f19 and f16 in regulating cells absorption of SCFAs (<em>P</em> < 0.05). The protein and mRNA expression levels of monocarboxylate transporter 1, Na<sup>+</sup>/H<sup>+</sup> exchanger 2 (NHE2), NHE3, and putative anion transporter 1 transporters in cells were significantly regulated by surface proteins (SP) of f19 and f16 (<em>P</em> < 0.05); meanwhile, there are also significant differences between the SP of f19 and f16 in regulating transporters (<em>P</em> < 0.05). <em>L. plantarum</em> f19 and f16 improve the absorption of SCFAs by intestinal epithelial Caco-2 cells by regulating the expression of SCFAs transporters through their SP.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106896"},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acanthopanax trifoliatus (L.) Merr polysaccharides: A novel therapeutic agent for hyperuricemia management 三叶五加(L.)枸杞多糖：一种治疗高尿酸血症的新药物

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-17 DOI: 10.1016/j.jff.2025.106893

Guoyu Wu , Yuzi Lin , Qi Chen , Jinghua Pan , Guixiang Wang , Yufang Pan

引用次数: 0

Protective role of bee pollen-enriched soy milk in enhancing renal function and alleviating nephrotoxicity 蜂花粉豆浆增强肾功能和减轻肾毒性的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-17 DOI: 10.1016/j.jff.2025.106880

Hanaa S.S. Gazwi , Eman E. Yassien , Maha M. Bikheet , Moshira M. Shaban , Waleed M. Abdel-Aleem , Amal F. Alqurashi , Asmaa H. Zaki

{"title":"Protective role of bee pollen-enriched soy milk in enhancing renal function and alleviating nephrotoxicity","authors":"Hanaa S.S. Gazwi , Eman E. Yassien , Maha M. Bikheet , Moshira M. Shaban , Waleed M. Abdel-Aleem , Amal F. Alqurashi , Asmaa H. Zaki","doi":"10.1016/j.jff.2025.106880","DOIUrl":"10.1016/j.jff.2025.106880","url":null,"abstract":"<div><div>This study investigates the protective effects of soy milk fortified with Bee Pollen (SMBP) against renal damage in a rat model. The rats were divided into four groups: control, SMBP-treated, cisplatin-treated, and cisplatin + SMBP co-treated. Kidney function was assessed by measuring serum urea, creatinine, and uric acid levels. Oxidative stress was evaluated through malondialdehyde (MDA) levels, and antioxidant enzyme activities (GSH, SOD, and CAT) were measured. Inflammatory and apoptotic markers (NF-κB, IL-8, TNF-α, caspase-3, and caspase-9) were also analyzed, along with histopathological changes and immunohistochemical expression of NF-κB and cytochrome C. The results showed that adding 1 %, 3 %, and 5 % bee pollen to soy milk significantly increased protein content from 3.85 % in the control group to 9.26 % in the 5 % bee pollen sample. Bee pollen concentrations also enhanced antioxidant activity, total solids, and phenolic and flavonoid levels. Cisplatin treatment caused significant renal dysfunction, oxidative stress, elevated inflammatory markers, and apoptosis, accompanied by histopathological changes. Co-treatment with SMBP significantly reduced these effects, improving kidney function, reducing oxidative stress, and lowering inflammation and apoptosis. Histological analysis showed restored kidney architecture. These findings suggest that SMBP has strong nephroprotective properties, effectively counteracting renal damage through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106880"},"PeriodicalIF":3.8,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passiflora edulis leaves polysaccharides mitigate DSS-induced ulcerative colitis in mice via inflammation inhibition and gut microbiota modulation 西番莲叶多糖通过炎症抑制和肠道菌群调节减轻dss诱导的小鼠溃疡性结肠炎

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-16 DOI: 10.1016/j.jff.2025.106891

Rongbing Huang, Yuebei Cai, Xuhan Wang, Tieming Jiang, Hock Eng Khoo, Jing Li, Xinhong Dong, Yuan Guan, Xia Li

{"title":"Passiflora edulis leaves polysaccharides mitigate DSS-induced ulcerative colitis in mice via inflammation inhibition and gut microbiota modulation","authors":"Rongbing Huang, Yuebei Cai, Xuhan Wang, Tieming Jiang, Hock Eng Khoo, Jing Li, Xinhong Dong, Yuan Guan, Xia Li","doi":"10.1016/j.jff.2025.106891","DOIUrl":"10.1016/j.jff.2025.106891","url":null,"abstract":"<div><div>Treatment of ulcerative colitis (UC) usually includes medications or surgery. Meanwhile, natural plant polysaccharides show significant potential for preventing and complementing therapy in UC. This study investigates the effects and mechanisms of polysaccharides extracted from <em>Passiflora edulis</em> leaves via hot water (WPEL) and alkali (APEL) on UC mice induced by dextran sodium sulfate (DSS). The results showed that both polysaccharides alleviated pathological symptoms in colitis mice (weight loss, bloody stools, and colon shortening), down-regulated oxidative stress markers (CAT, GSH-Px, SOD, and T-AOC), and reduced inflammatory cytokines (IL-6, TNF-α, IL-1β, and CRP). Additionally, both polysaccharides altered the composition and abundance of intestinal microbiota, enhancing short-chain fatty acids (SCFAs) production. These findings suggested that polysaccharides derived from <em>Passiflora edulis</em> leaves could be used in developing functional foods and therapeutic drugs to prevent and alleviate colitis, thereby providing a strong basis for further research into the application of <em>P. edulis</em> in UC and related disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106891"},"PeriodicalIF":3.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of functional foods based on probiotics in improving fertility: A review1 基于益生菌的功能食品在提高生育能力中的作用综述

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-16 DOI: 10.1016/j.jff.2025.106871

Nader Khani , Mansour Rabie Ashkezary , Negin Hosseinzadeh , Baharak Aghapour , Asad Hosseini , Roya Abedi Soleimani , Sousan Houshmandi , Seyed mohamad javad Shokouhian , Aziz Homayouni-Rad

{"title":"The role of functional foods based on probiotics in improving fertility: A review1","authors":"Nader Khani , Mansour Rabie Ashkezary , Negin Hosseinzadeh , Baharak Aghapour , Asad Hosseini , Roya Abedi Soleimani , Sousan Houshmandi , Seyed mohamad javad Shokouhian , Aziz Homayouni-Rad","doi":"10.1016/j.jff.2025.106871","DOIUrl":"10.1016/j.jff.2025.106871","url":null,"abstract":"<div><div>Many foods are described as “functional foods”. However, the term is poorly defined. A commonly used definition is that they contain substances that have positive effects on health “beyond basic nutrition”. On a global scale, significant emphasis has been placed on their ingestion as a cost-effective and safer alternative for the prevention, treatment, and management of various health-related issues, including reproductive challenges such as infertility. Infertility represents a condition that is notably common among certain married couples and is characterized by the inability to conceive following approximately twelve months of unprotected sexual intercourse between heterosexual partners. There are different types of functional foods that can have effects that improve fertility in couples, including Animal-derived functional foods, Plant-derived functional foods, and Microbial functional foods (based on probiotics). Functional foods based on probiotics produced through fermentation, which include kefir, yogurt, cheese and fermented milk. This review highlights the possible role of functional foods based on probiotics in improving fertility.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106871"},"PeriodicalIF":3.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0