Journal of Functional Foods最新文献

{"title":"Sparalide B from Sparassis latifolia inhibits early adipogenesis in 3T3-L1 adipocytes via β-catenin-dependent downregulation of PPARγ and C/EBPα","authors":"Hyeok Jin Choi ,&nbsp;Jeong Won Choi ,&nbsp;So Jung Park ,&nbsp;Gyeong Eun Im ,&nbsp;Youngki Park ,&nbsp;Kyoung Tae Lee ,&nbsp;Jin Boo Jeong","doi":"10.1016/j.jff.2026.107167","DOIUrl":"10.1016/j.jff.2026.107167","url":null,"abstract":"<div><div>Sparalide B, a phthalide isolated from <em>Sparassis latifolia</em> (<em>S. latifolia</em>), was structurally assigned as 4,5,7-trihydroxy-6-ethoxyphthalide by high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) (¹H, ¹³C, heteronuclear multiple bond correlation (HMBC)) analyses. In 3T3-L1 adipocytes, sparalide B (2.5–20 μg/mL) significantly reduced lipid droplet accumulation in a dose-dependent manner, as quantified by Oil Red O staining at concentrations that did not affect cell viability. Western blotting showed decreased expression of adipogenic transcription factors (PPARγ, C/EBPα) and lipid droplet-associated/lipolytic proteins (perilipin-1, ATGL, HSL), alongside increased levels of thermogenesis/energy-metabolism markers (UCP2, PGC-1α, p-AMPK, AMPK). Stage-restricted treatments revealed that efficacy was confined to the early differentiation window (D0-D2), with little effect during D2-D4 or D4-D8. Mechanistically, sparalide B elevated β-catenin during D0-D2; β-catenin knockdown abrogated the compound's suppression of PPARγ/C/EBPα and its inhibition of lipid accumulation. These findings indicate that sparalide B targets early adipogenesis through β-catenin-dependent signaling to suppress lipid formation, highlighting this natural phthalide as a promising anti-obesity lead.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"137 ","pages":"Article 107167"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of consumption of selenium biofortified milk on antioxidant and inflammatory biomarkers in children with autism spectrum disorder: A controlled, single-blind intervention study","authors":"Marta Liliane de Vasconcelos ,&nbsp;Fábio da Veiga Ued ,&nbsp;Marcia Delgado da Cruz Gomes ,&nbsp;Luiz Fernando Costa e Silva ,&nbsp;Giovana Fumes Ghantous ,&nbsp;Arlindo Saran Netto ,&nbsp;João Alberto Negrão ,&nbsp;Jeremy Paul Hill ,&nbsp;Ana Maria Centola Vidal","doi":"10.1016/j.jff.2026.107161","DOIUrl":"10.1016/j.jff.2026.107161","url":null,"abstract":"<div><div>Children with Autism Spectrum Disorder (ASD) often exhibit food selectivity, which may be associated with inadequate Selenium (Se) intake and imbalances in serum levels of enzymatic and non-enzymatic antioxidants as well as inflammatory cytokines. Several studies suggest an association between autism and increased oxidative stress. However, clinical studies in this population remain scarce due to methodological challenges, as do studies assessing Se status and the effects of Se biofortified foods. In this context, the present study aimed to quantify serum levels of Se, zinc (Zn), vitamin E (VitE), antioxidant enzymes, and pro-inflammatory cytokines in children with ASD before and after dietary intervention with Se biofortified cow's milk. Seventeen children with ASD aged between 3 and 10 years were selected and allocated into a conventional milk (<em>n</em> = 8), and the Se biofortification group (<em>n</em> = 9), which received cow's milk containing 190 μg/L of Se for 12 weeks (84 days). Serum levels of enzymatic and non-enzymatic antioxidants and gene expression of pro-inflammatory cytokines were measured at baseline and the end of the study. Following the intervention, serum Se levels were significantly higher in the biofortified group (62.97 vs 102.82 μg/dL, <em>p</em> &lt; 0.05). No significant differences were observed in antioxidant enzyme expression; although not statistically significant, greater glutathione peroxidase 1 (GPx1) and catalase (CAT) levels were observed post-intervention, as well as a tendency toward lower VitE and Zn levels. Among the measured pro-inflammatory cytokines, only interleukin 8 (IL-8) significantly increased. Tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) showed a positive correlation with antioxidant enzymes (<em>p</em> &lt; 0.05). These findings suggest that Se biofortification of milk may serve as a potential nutritional strategy for children with ASD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"137 ","pages":"Article 107161"},"PeriodicalIF":4.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145974517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UTMD technology mediates the application of resveratrol nanocarriers in the diagnosis and treatment of gastric cancer","authors":"Xiao Gan ,&nbsp;Qiqing Zheng ,&nbsp;Pengfei Wang ,&nbsp;Zhewei Zhang ,&nbsp;Bohan Zhang ,&nbsp;Jingyue Li ,&nbsp;Liang Wang ,&nbsp;Zhilin Zhao","doi":"10.1016/j.jff.2025.107143","DOIUrl":"10.1016/j.jff.2025.107143","url":null,"abstract":"<div><div>Gastric cancer remains one of the most prevalent and lethal malignancies worldwide. Resveratrol has demonstrated significant anticancer properties across multiple cancer types, including gastric cancer. However, its therapeutic efficacy is limited by poor bioavailability and rapid metabolic clearance. Recent advances in nanotechnology have enabled the development of innovative drug delivery systems combining ultrasound-targeted microbubble destruction (UTMD) technology with nanocarriers, Exploiting the enhanced permeability and retention (EPR) effect, nanotech-based drug delivery system facilitate enhanced vascular penetration and tumor tissue accumulation, resulting in prolonged systemic circulation, improved therapeutic efficiency, and reduced systemic toxicity. The integration of nanotechnology-based delivery systems with UTMD technology enhances the bioavailability of poorly soluble drugs while providing a safe and targeted approach for resveratrol delivery, thereby optimizing its therapeutic and diagnostic potential in gastric cancer treatment. This review explores the applications of UTMD-mediated resveratrol nanocarriers in the diagnosis and treatment of gastric cancer.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107143"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cooked highland red rice ameliorates diabetic symptoms via gut microbiota-metabolite interactions in streptozotocin-induced mice","authors":"Zuming Li ,&nbsp;Leyi Zhao ,&nbsp;Liyuan Wang ,&nbsp;Xinyu Shao ,&nbsp;Ziqing Cheng ,&nbsp;Shiquan Si ,&nbsp;Xuhua Yang ,&nbsp;Yongxin She ,&nbsp;Xiaomeng Yang ,&nbsp;Michael Zhang ,&nbsp;Peixuan Shen ,&nbsp;Xikun Yan ,&nbsp;Yawen Zeng ,&nbsp;Xia Li","doi":"10.1016/j.jff.2025.107150","DOIUrl":"10.1016/j.jff.2025.107150","url":null,"abstract":"<div><div>Highland red rice is nutrient-rich due to its unique geographical location. However, systematic studies examining its antidiabetic effects and the underlying mechanisms are limited. In this study, cooked highland red rice (CHRR) was incorporated into a specialized feed and used as a dietary intervention in streptozotocin (STZ)-induced diabetic mice. CHRR intervention significantly reduced hyperglycemia, improved lipid dysregulation, alleviated hepatic oxidative stress, and restored pancreatic β-cell function. Furthermore, CHRR markedly increased the relative abundances of beneficial bacteria, including <em>Dubosiella</em><strong>,</strong> <em>Faecalibaculum</em>, <em>Romboutsia</em>, and <em>Turicibacter</em>. These beneficial microbial communities facilitated favorable alterations in intestinal metabolites. Notably, CHRR significantly increased short-chain fatty acid (SCFA) levels and decreased nucleotide metabolites (e.g., xanthosine, xanthine, and inosine). Correlation analyses showed that <em>Dubosiella</em> and <em>Faecalibaculum</em> were negatively correlated with nucleotide metabolites, suggesting their potential roles in modulating nucleotide metabolism. In conclusion, these findings suggest that highland red rice may ameliorate diabetic symptoms through the modulation of gut microbiota composition and metabolite profiles, supporting its potential development as a functional food for diabetes management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107150"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of MOS-Lactobacillus rhamnosus microcapsules by spray drying and its evaluation under gastrointestinal and fermentation with T2D mice feces","authors":"Erna Li ,&nbsp;Junyao Qin ,&nbsp;Yuxiao Zou ,&nbsp;Fan Liu ,&nbsp;Daorui Pang ,&nbsp;Qian Li ,&nbsp;Zechun Hong ,&nbsp;Siyuan Wang","doi":"10.1016/j.jff.2025.107146","DOIUrl":"10.1016/j.jff.2025.107146","url":null,"abstract":"<div><div><em>Lactobacillus</em> has the functions of regulating blood sugar, lowering cholesterol, and regulating intestinal flora. However, it is poorly tolerated by the human gastrointestinal fluid, which affects its survival in the intestine and reduces the effectiveness of <em>Lactobacillus</em>. This study developed microencapsulated <em>Lactobacillus rhamnosus</em> using mulberry oligosaccharides and maltodextrin (1:3) <em>via</em> spray drying to enhance probiotic viability. The spherical microcapsules (75.18 ± 4.32 μm) demonstrated high encapsulation efficiency and promoted bacterial proliferation. <em>In vitro</em> tests revealed exceptional gastrointestinal protection, maintaining viable counts above 4.53 lg CFU/g after digestion, and significant hypoglycemic activity. In type 2 diabetic mice, treatment modulated gut microbiota by increasing <em>Firmicutes</em> and <em>Lactobacillus</em> abundances while reducing <em>Proteobacteria</em> and <em>Escherichia-Shigella</em>. These findings demonstrate that the microcapsules wall materials provide effective gastrointestinal protection. Core materials provide hypoglycemic function, and microbiota remodeling. Our results inform the potential for the development of mulberry oligosaccharides and probiotics as an intestinal-targeted delivery system.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107146"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant activity of Hassawi rice and sprouted Hassawi rice and its effect on lipid peroxidation and liver enzyme in hyperlipidemic rats","authors":"Ahlam Saleh Alhajri","doi":"10.1016/j.jff.2025.107148","DOIUrl":"10.1016/j.jff.2025.107148","url":null,"abstract":"<div><div>This study aimed to evaluate the antioxidant capacity and cholesterol-lowering effects of Hassawi rice in an experimental model of hyperlipidemia. A total of 48 albino rats were used to compare Hassawi rice powder (HR) and sprouted Hassawi rice (SHR) at 5% and 10% dietary inclusion over 28 days. SHR, particularly at 10%, significantly improved liver enzymes aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)reduced serum lipids, including triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), decreased oxidative markers, nitric oxide/nitrite (NO) and thiobarbituric acid reactive substances (TBARS), and elevated high-density lipoprotein cholesterol (HDL–C), superoxide dismutase (SOD), and reduced glutathione (GSH). SHR was more effective than HRP and the standard drug fenofibrate. Histological analysis showed substantial restoration of liver and heart architecture. These findings demonstrate SHR has strong antioxidants and anti-hyperlipidemic properties, highlighting its potential as a dietary intervention for oxidative stress-related disorders such as hyperlipidemia.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107148"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol in food systems: challenges, innovations, and health potential","authors":"Jenny Bouchard ,&nbsp;Nicola Gasparre ,&nbsp;Thomas Netticadan ,&nbsp;Cristina M. Rosell","doi":"10.1016/j.jff.2025.107127","DOIUrl":"10.1016/j.jff.2025.107127","url":null,"abstract":"<div><div>The integration of resveratrol, a naturally occurring, health promoting polyphenolic stilbene, into food systems poses a challenge due to its low water solubility, chemical instability, poor bioavailability, and bitter taste. To address these limitations, recent studies have focused on incorporating resveratrol into a range of food matrices such as wine, bakery, dairy, and meat products, using encapsulation techniques designed to enhance its stability during processing, maintain its therapeutic effects, and preserve desirable sensory attributes. This review provides a comprehensive overview of resveratrol’s plant sources, chemical characteristics, bioavailability, and health-promoting mechanisms while critically examining recent innovations in food-grade delivery systems, the functional roles of resveratrol in fortified food products and the associated barriers. Emphasis is placed on formulation challenges, matrix-specific applications, and future directions to improve consumer-relevant health benefits.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107127"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel ACE inhibitory peptide from Gadus morhua skin: Isolation, characterization and antihypertensive mechanisms","authors":"Shuai Li ,&nbsp;Jie Huai ,&nbsp;Bingfu Yang ,&nbsp;Cunxi Lu ,&nbsp;Junjie Qiu ,&nbsp;Yi Ding ,&nbsp;Renjie Zhou ,&nbsp;Shan Wang","doi":"10.1016/j.jff.2025.107133","DOIUrl":"10.1016/j.jff.2025.107133","url":null,"abstract":"<div><div>This study aimed to develop a novel ACE inhibitory peptide from cod skin with antihypertensive activity. Cod skin collagen hydrolysate was prepared by stepwise enzymatic hydrolysis using Collagen hydrolase followed by flavourzyme. The hydrolysate was purified by ultrafiltration, Sephadex G-25 chromatography, and preparative HPLC. A new ACE inhibitory peptide, GPAGPSGP (638.67 Da), was identified with an IC₅₀ of 179 ± 12 μM, retaining 97.49 % activity after simulated gastrointestinal digestion. Mixed-type inhibition was confirmed by kinetic analysis. Molecular docking revealed a binding energy of −10.1 kcal/mol for the GPAGPSGP–ACE interaction, indicating hydrophobic and polar residues mediate side-chain interactions in the ACE active site. The ACE-inhibitory peptide obtained from cod skin by two-enzyme hydrolysis showed strong activity, supporting its potential use in functional foods for hypertension management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107133"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-ultraviolet effects of astaxanthin derived from Haematococcus pluvialis microalgae on the skin, hair, and nails of Japanese people: A randomized, placebo-controlled, double-blind, parallel-group comparative study","authors":"Takahiro Sekikawa ,&nbsp;Yanmei Li ,&nbsp;Tatsuya Izumi","doi":"10.1016/j.jff.2025.107138","DOIUrl":"10.1016/j.jff.2025.107138","url":null,"abstract":"<div><div><em>Haematococcus</em> algae-derived astaxanthin (HPA) has been shown to exhibit potent anti-ultraviolet (UV) effects due to its antioxidative properties, confirming the effectiveness of an HPA intake of 4 mg/day to 12 mg/day for 10–16 weeks. However, whether an HPA intake of &lt;10 weeks produces a similar effect has not been determined. Thus, we evaluated the anti-UV effect of consuming 6 mg HPA per day for 8 weeks. This study included healthy Japanese individuals who were randomly assigned to either the HPA intake group or the non-HPA intake (placebo) group (<em>n</em> = 22 per group). The evaluation items were minimal erythema dose (MED), skin color, transdermal water loss, skin moisture content, skin viscoelasticity, and glycation stress indicators. HPA consumption significantly increased the MED and reduced the subjective dryness of the hair, suggesting that HPA exhibits anti-UV effects on the skin and hair (UMIN000053035).</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107138"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Bifidobacterium bifidum BB00 as adjunctive therapy for postoperative dry eye: a double-blind, randomised, placebo-controlled trial","authors":"Chiwen Cheng ,&nbsp;Jingjing Xu ,&nbsp;Yixiao Zhang ,&nbsp;Shuhuan Yu ,&nbsp;Yunfeng Duan ,&nbsp;Kang Yu ,&nbsp;Qing Wang ,&nbsp;Yangyang Peng ,&nbsp;Yanqing Li ,&nbsp;Wen Yao ,&nbsp;Yijie Pi ,&nbsp;Jing Wei ,&nbsp;Tingtao Chen ,&nbsp;Yifeng Yu","doi":"10.1016/j.jff.2025.107140","DOIUrl":"10.1016/j.jff.2025.107140","url":null,"abstract":"<div><div>This study investigated the effect of <em>Bifidobacterium bifidum</em> BB00 supplementation on the prevention of postoperative dry eye (DE) following refractive surgery. In this randomised, double-blind, placebo-controlled trial, 100 patients received either BB00 (2 × 10⁹ CFU/day) or placebo for 30 days. DE incidence, ocular surface disease index (OSDI), fluorescein breakup time (FBUT), and Schirmer I test results were assessed, while gut microbiota composition was analysed via 16S rRNA sequencing. Among the 89 participants who completed the study, BB00 supplementation significantly reduced DE incidence and improved OSDI, FBUT, and Schirmer I values (all <em>p</em> &lt; 0.05) compared with placebo. Surgery-induced dysbiosis, characterised by reduced <em>Bifidobacterium</em> and elevated <em>Prevotella</em> abundance, was partially reversed. Although BB00 supplementation delayed DE onset and improved ocular surface parameters, no significant effect on corneal healing was observed under the experimental conditions applied (<em>p</em> &gt; 0.05).</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107140"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}