Journal of Functional Foods最新文献_第8页

Metabolomic insights into the beneficial effects of dietary purple potato on DSS-induced murine colon colitis 代谢组学揭示膳食紫薯对 DSS 诱导的小鼠结肠炎的有益影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-26 DOI: 10.1016/j.jff.2024.106538

Qi Sun , Alejandro Bravo Iniguez , Shima Bibi , Carolyn H. Bohach , Scott A. Minnich , ‬Min Du , Mei-Jun Zhu

{"title":"Metabolomic insights into the beneficial effects of dietary purple potato on DSS-induced murine colon colitis","authors":"Qi Sun , Alejandro Bravo Iniguez , Shima Bibi , Carolyn H. Bohach , Scott A. Minnich , ‬Min Du , Mei-Jun Zhu","doi":"10.1016/j.jff.2024.106538","DOIUrl":"10.1016/j.jff.2024.106538","url":null,"abstract":"<div><div>Inflammatory bowel disease (IBD) is characterized by disturbances in intestinal flora and metabolomic profiles. Building on previous findings that purple potato (PP) supplementation suppresses inflammation and restores intestinal barrier in dextran sulfate sodium (DSS)-treated mice, this study examined changes in the fecal metabolome in the same cohort. Mice were fed 0 % or 10 % PP for 7 weeks, with DSS administered in the fifth week of dietary treatment followed by one-week normal drinking water recovery. A total of 68 metabolites, including amino acids, fatty acids, organic acids, carbohydrates, and polyamines, were significantly altered across the groups. PP supplementation reversed changes in 13 of the 25 DSS-altered metabolites. Six microbial metabolites derived from PP polyphenols were identified and positively correlated with M2 macrophage polarization. Data suggest that dietary PP is effective in reducing inflammation and improves gut metabolites in DSS-induced colitis mice, offering a potential dietary therapy for managing IBD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106538"},"PeriodicalIF":3.8,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Fischer ratio oligopeptides from Antarctic krill: Ameliorating function and mechanism to alcoholic liver injury through regulating AMPK/Nrf2/IκBα pathways 来自南极磷虾的高费舍尔比寡肽：通过调节 AMPK/Nrf2/IκBα 通路改善酒精性肝损伤的功能和机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-25 DOI: 10.1016/j.jff.2024.106537

Xiao-Meng Dong , Shi-Kun Suo , Yu-Mei Wang , Yu-Hui Zeng , Chang-Feng Chi , Bin Wang

{"title":"High Fischer ratio oligopeptides from Antarctic krill: Ameliorating function and mechanism to alcoholic liver injury through regulating AMPK/Nrf2/IκBα pathways","authors":"Xiao-Meng Dong , Shi-Kun Suo , Yu-Mei Wang , Yu-Hui Zeng , Chang-Feng Chi , Bin Wang","doi":"10.1016/j.jff.2024.106537","DOIUrl":"10.1016/j.jff.2024.106537","url":null,"abstract":"<div><div>In this study, we devoted attention to the hepatoprotective functions of high Fischer ratio oligopeptides (HFOPs) from Antarctic krill (HFOPs-AK) on alcoholic liver injury of mice. The results indicated that HFOPs-AK significantly improved the pathological state of mice liver and kidney, reduced alanine aminotransferase (ALT) and aspartate transaminase (AST) activities, regulated lipid metabolism, and alleviated the burden on the liver. In addition, HFOPs-AK depicted anti-inflammatory and antioxidant effects by reducing tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) contents and increasing superoxide dismutase (SOD) and catalase (CAT) activities to reduce malondialdehyde (MDA) level. The hepatoprotective mechanism of HFOPs-AK was further revealed by quantitative reverse transcription PCR (RT-qPCR) analysis, and the results proved that HFOPs-AK had the ability to stimulate the adenosine 5‘-monophosphate-activated protein kinase (AMPK)/nuclearrespiratoty factor 2 (Nrf2)/inhibitor of NF-κB (IκBα) signaling pathways, thereby regulating the expression levels of downstream factors. The activation of these signaling pathways is essential for the regulation of lipid metabolism as well as anti-inflammatory and antioxidant functions. This finding offers a novel approach for the development of innovative hepatoprotective agents utilizing HFOPs-AK.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106537"},"PeriodicalIF":3.8,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ilex asprella-derived polysaccharide activates macrophage via TLR4-mediated NF-κB and MAPK signaling pathways Ilex asprella 衍生多糖通过 TLR4 介导的 NF-κB 和 MAPK 信号通路激活巨噬细胞

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-24 DOI: 10.1016/j.jff.2024.106527

Yao Wang , Lijing Ye , Ruikun Yan, Chuangchuang Guo, Miaohui Mu, Yuxuan Sun, Haibo Zhou, Guojun Zhao

{"title":"Ilex asprella-derived polysaccharide activates macrophage via TLR4-mediated NF-κB and MAPK signaling pathways","authors":"Yao Wang , Lijing Ye , Ruikun Yan, Chuangchuang Guo, Miaohui Mu, Yuxuan Sun, Haibo Zhou, Guojun Zhao","doi":"10.1016/j.jff.2024.106527","DOIUrl":"10.1016/j.jff.2024.106527","url":null,"abstract":"<div><div><em>Ilex asprella</em>, a valued herb in China, is recognized for its medicinal and dietary benefits, yet its active components and mechanisms of action have been largely unknown. This study focused on the polysaccharide extracted from <em>Ilex asprella</em> (IAP) and to investigate its structural characteristics and immunomodulatory effects. The results indicated IAP had a molecular weight of 3324 Da and was mainly composed of arabinose, galactose, glucose, and mannose. <em>In vitro</em> study showed 10, 50, and 100 μg/mL of IAP significantly increased the mRNA expression of inducible nitric-oxide synthase, cyclooxygenase-2, reactive oxygen, and cytokines in RAW264.7 macrophages. According to the results, IAP also facilitated the nucleus translocation of NF-κB p65 and activated the phosphorylation of p38, JNK, and ERK, revealing IAP activated RAW264.7 cells <em>via</em> NF-κB and MAPK signaling pathways. Furthermore, the results of membranes receptor inhibitor administration suggested toll-like receptor 4 might be the action target of IAP.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106527"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration the mechanism underlying protocatechuic acid in treating osteoporosis by HIF-1 pathway based on network pharmacology, molecular docking, molecular dynamics simulation and experimental verification 基于网络药理学、分子对接、分子动力学模拟和实验验证，探索原儿茶酸通过 HIF-1 通路治疗骨质疏松症的机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-24 DOI: 10.1016/j.jff.2024.106531

Xueqin Feng , Wei Feng , Peitong Wu , Shuo Wang , Kaiyue Zhang , Wanjie Liu , Jingwei Lv , Jingzhou Zhang , Jiaming Sun

{"title":"Exploration the mechanism underlying protocatechuic acid in treating osteoporosis by HIF-1 pathway based on network pharmacology, molecular docking, molecular dynamics simulation and experimental verification","authors":"Xueqin Feng , Wei Feng , Peitong Wu , Shuo Wang , Kaiyue Zhang , Wanjie Liu , Jingwei Lv , Jingzhou Zhang , Jiaming Sun","doi":"10.1016/j.jff.2024.106531","DOIUrl":"10.1016/j.jff.2024.106531","url":null,"abstract":"<div><div>Protocatechuic acid (PCA), a naturally occurring polyphenol abundant in fruits, vegetables, and various plants, exhibits diverse biological activities. However, the mechanism of action of PCA in osteoporosis (OP) is unclear. This study aims to elucidate the anti-OP mechanisms of PCA through an integrated approach involving network pharmacology, virtual screening, and experimental validation. In this study, we found that PCA improved zebrafish skeletal development and promoted MC3T3-E1 cell proliferation, increasing ALP activity. In addition, PCA decreased the level of ROS and MDA, increased the level of SOD, GSH and NO, and mitigated the degree of oxidative stress. Concurrently, network pharmacological analysis indicated that PCA upregulated core target levels, activated the HIF-1 signaling pathway, ameliorated oxidative stress, and exerted an anti-OP effect by promoting bone formation. In conclusion, PCA may provide a new strategy in the prevention and treatment of OP.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106531"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction, in vitro hypoglycaemic activity and active ingredient analysis of polyphenols from walnut green husk 核桃青皮多酚的提取、体外降血糖活性和有效成分分析

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-24 DOI: 10.1016/j.jff.2024.106508

Xia Hu , Jing Xie , Yu-Ying Bai , Zi-Shan Hong , Li Zhang , Wan-Ying Gong , Yue-Xiu Pan , Wen-Jing Wang , Min Su , Jun Sheng , Yang Tian

{"title":"Extraction, in vitro hypoglycaemic activity and active ingredient analysis of polyphenols from walnut green husk","authors":"Xia Hu , Jing Xie , Yu-Ying Bai , Zi-Shan Hong , Li Zhang , Wan-Ying Gong , Yue-Xiu Pan , Wen-Jing Wang , Min Su , Jun Sheng , Yang Tian","doi":"10.1016/j.jff.2024.106508","DOIUrl":"10.1016/j.jff.2024.106508","url":null,"abstract":"<div><div>A variety of polyphenols in walnut green husk have shown physiological benefits, but their primary hypoglycemic active ingredients remain unclear. We report the extraction of walnut green husk polyphenols (WGHP) and their hypoglycemic effects <em>in vitro</em>. WGHP was extracted using ultrasound-assisted ethanol extraction, with optimization via response surface methodology resulting in 88.0 ± 0.1 % purity after D101 macroporous resin purification. WGHP effectively inhibited α-glucosidase and α-amylase, with IC<sub>50</sub> values of 3.42 μg/mL and 2.56 mg/mL, respectively. It also increased glycogen synthesis in insulin-resistant HepG2 cells and enhanced glucose consumption in 3T3-L1 and insulin-resistant HepG2 cells. Screening six α-glucosidase ligands from WGHP using affinity ultrafiltration and UPLC-MS/MS, combined with molecular docking, identified hydrogen bonds and binding energies between the ligands and the enzyme. These results highlight the hypoglycemic potential of walnut green husk polyphenols and provide a basis for future therapeutic research.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106508"},"PeriodicalIF":3.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of probiotics with soy protein alleviate ulcerative colitis by repairing the intestinal barrier and regulating intestinal flora 益生菌与大豆蛋白的协同作用可通过修复肠道屏障和调节肠道菌群缓解溃疡性结肠炎

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-23 DOI: 10.1016/j.jff.2024.106514

Rentang Zhao , Bingqing Shang , Luyan Sun, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng

{"title":"Synergistic effects of probiotics with soy protein alleviate ulcerative colitis by repairing the intestinal barrier and regulating intestinal flora","authors":"Rentang Zhao , Bingqing Shang , Luyan Sun, Suyuan Lv, Guolong Liu, Qiu Wu, Yue Geng","doi":"10.1016/j.jff.2024.106514","DOIUrl":"10.1016/j.jff.2024.106514","url":null,"abstract":"<div><div>In this experiment, we used probiotic and soy protein as raw materials to intervene in DSS-induced acute ulcerative colitis in C57BL/6 mice, to investigate the mitigating effect and synergistic effect of the probiotic complex combined with soy protein. The results showed that the combination of probiotics and soy protein could effectively alleviate the symptoms in UC mice, and inhibit the inflammatory process by down-regulating the expression of IL-6 and TNF-α and reducing the infiltration of inflammatory cells. Histopathological results showed that probiotic and/or soy protein interventions were effective in reducing the DAI of colonic ulceration, repairing intestinal epithelial barrier damage, and up-regulating the expression of tight junction-associated proteins. The composition of intestinal microbiota in the SP group, YWSP group and SNSP group with soybean protein intervention showed similar characteristics. In conclusion, the combination of YW probiotic powder and soy protein exerted a good synergistic effect.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106514"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

6-Gingerol activates the Nrf2 signaling pathway to alleviate hydrogen peroxide induced oxidative stress on primary chicken embryo hepatocytes 6-姜酚激活 Nrf2 信号通路，缓解过氧化氢诱导的原代鸡胚肝细胞氧化应激反应

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-23 DOI: 10.1016/j.jff.2024.106535

Kaige Yang , Yunqi Lu , Zhiguang Yue , Sanjun Jin , Ping Wang , Chaoqi Liu , Lijun Wang , Qingqiang Yin , Xiaowei Dang , Hongwei Guo , Juan Chang

{"title":"6-Gingerol activates the Nrf2 signaling pathway to alleviate hydrogen peroxide induced oxidative stress on primary chicken embryo hepatocytes","authors":"Kaige Yang , Yunqi Lu , Zhiguang Yue , Sanjun Jin , Ping Wang , Chaoqi Liu , Lijun Wang , Qingqiang Yin , Xiaowei Dang , Hongwei Guo , Juan Chang","doi":"10.1016/j.jff.2024.106535","DOIUrl":"10.1016/j.jff.2024.106535","url":null,"abstract":"<div><div>Oxidative stress affects production performance and meat quality of poultry. 6-gingerol (6-Gin) is the main activity component of ginger, has shown promise in alleviating oxidative stress in broilers, However, the specific protection mechanism of 6-Gin against hepatocytes oxidative damage remains unclear. The primary chicken embryo hepatocytes (CEHs) were damaged and the cell viability was decreased by H<sub>2</sub>O<sub>2</sub>, 6-Gin can alleviate the cell injure and oxidative stress. Transcriptomic analysis and further experiments showed that H<sub>2</sub>O<sub>2</sub> significantly suppressed the expression of Nrf2, Keap1, and NQO1, as well as antioxidant enzyme activities, increased inflammatory factors, leading to cell apoptosis. In contrast, 6-Gin effectively reduced these effects by promoting Nrf 2 nuclear translocation and activating the Nrf2 signaling pathway. Furthermore, the protective effects of 6-Gin were eliminated by the Nrf2 inhibitor ML385. In conclusion, 6-Gin exerts antioxidant, anti-inflammatory and anti-apoptotic effects on CEHs through the Nrf2 pathway. This study provides the potential value of 6-Gin for treatment of oxidative stress in broilers.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106535"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absorption of food-derived balenine and its constituent amino acids in human plasma after ingestion of opah muscle and muscle extract in water 摄入鸦片鱼肌肉和水中肌肉提取物后，人体血浆中食物来源的巴利宁及其组成氨基酸的吸收情况

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-23 DOI: 10.1016/j.jff.2024.106521

Yasutaka Shigemura , Yu Iwasaki , Megumi Hosokawa , Yurika Arai , Takuya Seko , Ryo Sawada , Yasunosuke Kawabata , Kenji Ishihara

{"title":"Absorption of food-derived balenine and its constituent amino acids in human plasma after ingestion of opah muscle and muscle extract in water","authors":"Yasutaka Shigemura , Yu Iwasaki , Megumi Hosokawa , Yurika Arai , Takuya Seko , Ryo Sawada , Yasunosuke Kawabata , Kenji Ishihara","doi":"10.1016/j.jff.2024.106521","DOIUrl":"10.1016/j.jff.2024.106521","url":null,"abstract":"<div><div>Opah muscle is one of the abundant biological sources of balenine (Bal), which together with carnosine (Car) and anserine (Ans), is among the most widely studied of vertebrate imidazole dipeptides. The characteristics of imidazole dipeptides have been extensively investigated. We examined changes in the concentration of Bal and its constituent amino acids in human plasma following the ingestion of opah muscle extract and opah flesh. Bal plasma concentrations increased after ingestion, with maximum plasma concentrations (C<sub>max</sub>) of 89.87, 152.13, and 81.82 nmol/mL observed after ingestion of 5 and 10 g of opah muscle extract and 80 g of opah flesh, respectively. The constituent amino acids of Bal, 3-methyl-histidine (3-Me-His) and β-alanine (β-Ala), increased in plasma after ingestion. The C<sub>max</sub> of Bal was the highest of any food-derived peptide in human plasma reported to date. The findings showed that ingestion of opah muscle and muscle extract may be beneficial for human health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106521"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undaria pinnatifida Sporophyll and Gracilaria verrucosa Attenuate obesity-induced fat accumulation, adipose tissue macrophage infiltration, and systemic insulin resistance Undaria pinnatifida Sporophyll 和 Gracilaria verrucosa 可减轻肥胖引起的脂肪堆积、脂肪组织巨噬细胞浸润和全身性胰岛素抵抗

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-23 DOI: 10.1016/j.jff.2024.106509

Eunyoung Kim , Jiamei Cui , Kayeon Ko , Zemin Li , Yunpeng Wang , Soo Youn Choi , Yunkyoung Lee , Guiguo Zhang

{"title":"Undaria pinnatifida Sporophyll and Gracilaria verrucosa Attenuate obesity-induced fat accumulation, adipose tissue macrophage infiltration, and systemic insulin resistance","authors":"Eunyoung Kim , Jiamei Cui , Kayeon Ko , Zemin Li , Yunpeng Wang , Soo Youn Choi , Yunkyoung Lee , Guiguo Zhang","doi":"10.1016/j.jff.2024.106509","DOIUrl":"10.1016/j.jff.2024.106509","url":null,"abstract":"<div><div>The potential health-promoting effects of two edible seaweeds, <em>Undaria pinnatifida</em> sporophyll (UPS) and <em>Gracilaria verrucosa</em> (GV), were investigated by using <em>in vitro</em> and <em>in vivo</em> models. Water extracts of UPS and GV inhibited lipid accumulation in 3T3-L1 adipocytes by downregulating adipogenesis-related genes and stimulated lipolysis in mature adipocytes. In C57BL/6 mice, supplementation with UPS and GV powders ameliorated diet-induced obesity, insulin resistance, and systemic inflammation, resulting in lighter subcutaneous adipose tissue and decreased macrophage markers (<em>F4/80</em>, <em>Cd11c</em>, <em>Cd206</em>) and proinflammatory genes (<em>Tnf-α, Il-1β, Il-6, Ccl2</em>) in gonadal adipose tissue. Liver weight and hepatic triglyceride levels were also significantly lowered. Taken together, UPS and GV supplementation effectively prevented diet-induced obesity and chronic inflammation making them promising dietary ingredients for managing obesity and its associated disorders.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106509"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol modulates ferroptosis: Promising therapeutic targets in ischemia-reperfusion 白藜芦醇调节铁蛋白沉积：缺血再灌注的有望治疗靶点

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2024-10-23 DOI: 10.1016/j.jff.2024.106520

Guixiu Zeng , Jingwen Liang , Xiang Jie , Yuxing Chen , Luming Qi , Zhengping Wu , Sha Wu , Yao Li

{"title":"Resveratrol modulates ferroptosis: Promising therapeutic targets in ischemia-reperfusion","authors":"Guixiu Zeng , Jingwen Liang , Xiang Jie , Yuxing Chen , Luming Qi , Zhengping Wu , Sha Wu , Yao Li","doi":"10.1016/j.jff.2024.106520","DOIUrl":"10.1016/j.jff.2024.106520","url":null,"abstract":"<div><div>Ischemia-reperfusion (I/R) injury is an inevitable pathological process in many clinical practices, such as transplantation, myocardial infarction, cerebral infarction and current treatments for I/R injury are limited. Ferroptosis is an essential pathogenic mechanism for triggering I/R injury, characterized by excess reactive oxygen species (ROS) accompanied by lipid peroxidation and increased intracellular iron concentration consistent with the mechanical manifestations of I/R. Resveratrol (RES) is a polyphenolic compound found in red wine that acts as an iron chelator, lipophilic antioxidant, and lipid peroxidation inhibitor. It helps to inhibit I/R damage by reversing ferroptosis-induced cell death, providing insights into developing therapeutic strategies for this devastating disease. In this review, we used the keywords “ferroptosis”, “resveratrol”, and “ischemia-reperfusion” in conjunction with each other, collected 1039 papers from the last decade, 114 relevant papers were screened to review the research progress on the mitigating of I/R injury through ferroptosis in Res and its future perspectives.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"122 ","pages":"Article 106520"},"PeriodicalIF":3.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0