Journal of Functional Foods最新文献_第8页

Protective effect of mulberry galacto-oligosaccharide on DSS-induced colitis in mice 桑葚半乳糖低聚糖对dss诱导小鼠结肠炎的保护作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-28 DOI: 10.1016/j.jff.2025.106973

Yuxiao Zou , Dongxu Xing , Xiaohan Guo , Xinru Chen , Daorui Pang , Qian Li , Sentai Liao , Weiwei Cheng , Erna Li

引用次数: 0

Therapeutic effects of Lacticaseibacillus paracasei PC-H1 in alleviating colitis through restoring intestinal barrier and regulating gut microbiota 副干酪乳杆菌PC-H1通过恢复肠道屏障和调节肠道菌群减轻结肠炎的治疗作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-26 DOI: 10.1016/j.jff.2025.106974

Guoding Cao , Hanyue Zhu , Shuang Liang , Wanyu Cao , Ran Liu , Xinhang Li , Yichen Jiang , Yong Fang

{"title":"Therapeutic effects of Lacticaseibacillus paracasei PC-H1 in alleviating colitis through restoring intestinal barrier and regulating gut microbiota","authors":"Guoding Cao , Hanyue Zhu , Shuang Liang , Wanyu Cao , Ran Liu , Xinhang Li , Yichen Jiang , Yong Fang","doi":"10.1016/j.jff.2025.106974","DOIUrl":"10.1016/j.jff.2025.106974","url":null,"abstract":"<div><div>Ulcerative colitis (UC), a subtype of inflammatory bowel disease (IBD), disrupts intestinal barrier integrity and microbial homeostasis. This study investigated the therapeutic potential of <em>Lactobacillus paracasei</em> PC-H1 in a murine UC model. <em>L. paracasei</em> PC-H1 administration significantly ameliorated colitis severity, as evidenced by restored body weight, colon length, and reduced disease activity index (DAI) scores and pro-inflammatory cytokine levels. Mechanistically, <em>L. paracasei</em> PC-H1 enhanced mucosal barrier function by upregulating tight junction proteins (ZO-1, occludin, claudin-3) and controlling colonic inflammation. Notably, high-dose inactive <em>L. paracasei</em> PC-H1 outperformed viable bacteria in reshaping gut microbiota composition and establishing a novel microbial homeostasis. These findings demonstrate that <em>L. paracasei</em> PC-H1 mitigates ulcerative colitis progression by protecting intestinal barrier integrity and restoring microbiota homeostasis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106974"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eicosapentaenoic acid reduces fibromyalgia pain by inhibiting the microglia/astrocyte and toll-like receptor 4 pathway in the mouse brain 二十碳五烯酸通过抑制小鼠大脑中的小胶质细胞/星形胶质细胞和toll样受体4通路来减轻纤维肌痛疼痛

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-26 DOI: 10.1016/j.jff.2025.106976

I-Han Hsiao , Hsin-Cheng Hsu , Hsien-Yin Liao , Hsiang-Ming Huang , Yi-Wen Lin

{"title":"Eicosapentaenoic acid reduces fibromyalgia pain by inhibiting the microglia/astrocyte and toll-like receptor 4 pathway in the mouse brain","authors":"I-Han Hsiao , Hsin-Cheng Hsu , Hsien-Yin Liao , Hsiang-Ming Huang , Yi-Wen Lin","doi":"10.1016/j.jff.2025.106976","DOIUrl":"10.1016/j.jff.2025.106976","url":null,"abstract":"<div><div>The role of eicosapentaenoic acid (EPA) in fibromyalgia (FM) pain are limited. FM, defined as pain that persists for several months, is an increasing medical challenge with significant implications for patients, the economy, and society. A FM pain mouse model was performed using intermittent cold stress (ICS). Mechanical (2.07 ± 0.12 g) and thermal (4.55 ± 0.36 s) hyperalgesia was initiated after ICS induction in the FM pain mouse model. Results showed that the detrimental effects of ICS were relieved via the oral administration of EPA (100 mg/kg/day, 3.52 ± 0.12 g and 7.11 ± 0.37 s). The overexpression of the microglia, astrocyte, and toll-like receptor 4 signaling pathways was found in the nociceptive ascending pathway of FM mice, including the thalamus, somatosensory cortex, anterior cingulate cortex, and medial prefrontal cortex, which is associated with FM initiation. These phenomena could be further attenuated by EPA administration. EPA intake can be beneficial for FM management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106976"},"PeriodicalIF":3.8,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical review of Luteolin's effects on glycolipid metabolism and the underlying molecular mechanisms 木犀草素对糖脂代谢的影响及其分子机制综述

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-25 DOI: 10.1016/j.jff.2025.106972

Athulya Sojan , Baojun Xu

{"title":"A critical review of Luteolin's effects on glycolipid metabolism and the underlying molecular mechanisms","authors":"Athulya Sojan , Baojun Xu","doi":"10.1016/j.jff.2025.106972","DOIUrl":"10.1016/j.jff.2025.106972","url":null,"abstract":"<div><div>The increasing global incidence of diabetes and obesity has heightened the desire for safer, more effective, and natural treatment agents. Luteolin, a flavonoid prevalent in fruits, vegetables, and herbs, has demonstrated potential antidiabetic and anti-obesity properties among dietary polyphenols. This article analyzes the molecular pathways that contribute to luteolin's therapeutic efficacy in the treatment of diabetes and obesity. Luteolin exhibits antidiabetic effects via diminishing oxidative stress, improving insulin sensitivity through modifications in insulin signaling pathways, and blocking enzymes like α-glucosidase and α-amylase that are integral to glucose metabolism. Concurrently, its anti-obesity actions encompass the suppression of adipogenesis, promotion of lipolysis, augmentation, improvement of gut microbiota composition, and mitigation of chronic inflammation and oxidative stress in adipose tissues. The poor bioavailability and the pharmacokinetics of luteolin are also examined. Moreover, many in vivo preclinical investigations validate luteolin's preventive effects in mitigating hyperglycemia, insulin resistance, hepatic steatosis, and inflammation generated by obesity. Luteolin is a promising natural supplement for the integrated control of diabetes and obesity through multi-targeted molecular pathways with minimal side effects. This narrative review encompasses around 19 in vivo animal studies and 3 human studies chosen for their mechanistic insights into the modulation of glycolipid metabolism by luteolin. Studies were included that evaluated the molecular mechanisms underlying the antidiabetic and anti-obesity effects of luteolin. The scarcity of human data and issues related to bioavailability underscore the necessity for clinical trials and formulation studies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106972"},"PeriodicalIF":3.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bergenin suppresses the changes of gut microbiota and colitis induced by dextran sulfate sodium in KM mice 甜菜根素对葡聚糖硫酸钠诱导的KM小鼠肠道菌群变化及结肠炎有抑制作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-25 DOI: 10.1016/j.jff.2025.106960

Zhaoxia Yu , Jideng Ma , Yumei Zhang , Zhiyaun Li , Yougang Ke , Huan Chen , Yisheng Wang , Lixia Yu

{"title":"Bergenin suppresses the changes of gut microbiota and colitis induced by dextran sulfate sodium in KM mice","authors":"Zhaoxia Yu , Jideng Ma , Yumei Zhang , Zhiyaun Li , Yougang Ke , Huan Chen , Yisheng Wang , Lixia Yu","doi":"10.1016/j.jff.2025.106960","DOIUrl":"10.1016/j.jff.2025.106960","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate bergenin's (BE) modulatory effects on gut microbiota dysbiosis and its therapeutic mechanisms in dextran sulfate sodium (DSS)-induced colitis.</div></div><div><h3>Methods</h3><div>Kunming mice (<em>n</em> = 18) were randomized into Control, DSS (2.5 % DSS, 7 days), and DSS + BE (50 mg/kg/day) groups. Disease activity index (DAI), histopathology, and 16S rRNA sequencing of cecal microbiota were analyzed. Inflammatory markers (TLR4, α-SMA, iNOS) and epithelial proliferation (BrdU) were assessed.</div></div><div><h3>Results</h3><div>BE significantly attenuated colitis severity versus DSS group: reduced weight loss (23.1 % vs. 41.5 %,<em>P</em> < 0.05), lowered DAI scores (8.2 vs. 14.7,<em>P</em> < 0.01), and improved histopathology (2.1 vs. 4.8,<em>P</em> < 0.01). BE restored microbial α-diversity (Shannon index: 3.2 ± 0.4 vs. 2.1 ± 0.6,<em>P</em> < 0.01) and specifically increased anti-inflammatory <em>Barnesiella</em> abundance (4.2 % → 11.7 %,<em>P</em> < 0.01). Beta-diversity analysis revealed BE maintained microbiota structural stability (DSS + BE vs. Control dissimilarity <16 % vs. DSS >88 % at genus level). BE suppressed DSS-induced TLR4 overexpression and restored colonic epithelial proliferation (BrdU).</div></div><div><h3>Conclusion</h3><div>Bergenin ameliorates DSS-colitis by restoring gut microbiota homeostasis (notably enriching <em>Barnesiella</em>), suppressing TLR4-mediated inflammation, and promoting epithelial repair, highlighting its potential as an IBD therapeutic.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106960"},"PeriodicalIF":3.8,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening of probiotic strains from human breast milk and evaluation of their potential anti-obesity properties 人母乳中益生菌菌株的筛选及其潜在抗肥胖特性的评价

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-24 DOI: 10.1016/j.jff.2025.106969

Xiangxiang Zhao , Ke Xie , Yanghong Wang , Yao He , Hua Wei , Xueying Tao

{"title":"Screening of probiotic strains from human breast milk and evaluation of their potential anti-obesity properties","authors":"Xiangxiang Zhao , Ke Xie , Yanghong Wang , Yao He , Hua Wei , Xueying Tao","doi":"10.1016/j.jff.2025.106969","DOIUrl":"10.1016/j.jff.2025.106969","url":null,"abstract":"<div><div>Human breast milk is a recognized potential source of probiotics. In this study, sixteen lactic acid bacteria (LAB) were isolated from human breast milk. Among them, eleven strains, including seven strains of <em>Limosilactobacillus fermentum</em> (<em>L. fermentum</em>) and four strains of <em>Lacticaseibacillus paracasei</em> (<em>L. paracasei</em>), were systematically evaluated for their probiotic properties. Comprehensive assays, including survival in acidic and simulated intestinal fluid, antioxidant capacity, surface physicochemical properties, adherence to intestinal epithelial cells, antimicrobial properties, and <em>in vitro</em> anti-obesity potential (α-glucosidase inhibitory activity, cholesterol removal capacity, bile salt hydrolase activity (BSH) and lipase activity), as well as antibiotic resistance patterns and a principal component analysis, were conducted. The results showed that ELPA01 could effectively reduce cholesterol levels and inhibit Gram-negative pathogens, while ELFE07 exhibited strong α-glucosidase inhibitory activity and high BSH and antioxidant activities. These results demonstrate that both ELPA01 and ELFE07 may be promising candidates for the next generation of anti-obesity probiotics.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106969"},"PeriodicalIF":3.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honey Bee and Stingless Bee products: Effects on microbial virulence factors and pathogenicity mechanisms 蜜蜂和无刺蜂产品：对微生物毒力因子和致病性机制的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-23 DOI: 10.1016/j.jff.2025.106967

Wen Jie Ng , Karolina Matejczuk , Kah Yaw Ee , Ioanna Boutrou , Peir Shinn Hew , Piotr Szweda , Dimitris Mossialos

{"title":"Honey Bee and Stingless Bee products: Effects on microbial virulence factors and pathogenicity mechanisms","authors":"Wen Jie Ng , Karolina Matejczuk , Kah Yaw Ee , Ioanna Boutrou , Peir Shinn Hew , Piotr Szweda , Dimitris Mossialos","doi":"10.1016/j.jff.2025.106967","DOIUrl":"10.1016/j.jff.2025.106967","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is an escalating global crisis. AMR is driven by the overuse and misuse of antibiotics leading to the rise of healthcare-associated infections (HAIs) worldwide. Therefore, a promising strategy to combat AMR targets virulence factors and biofilm formation by pathogens, which protect them from antibiotics and the host immune system. Quorum sensing (QS) inhibitors and biofilm formation blockers are emerging as novel therapeutic approaches. In this context, bee-derived products have demonstrated robust antimicrobial properties, particularly in combating antibiotic-resistant bacteria. Although antimicrobial activity exerted by honey bee products is well-documented, research into stingless bee products remains an underexplored field with great potential. This review for the first time provides a comparative and comprehensive update regarding the potential implementation of honey bee and stingless bee products in mitigating AMR by targeting virulence factors and pathogenicity mechanisms such as biofilms, offering valuable insights into their use as alternative or adjunctive therapies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106967"},"PeriodicalIF":3.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of Gynura procumbens in enhancing cytokine regulation in the cervix of rats induced by 7,12-dimethylbenz(a)anthracene: In vivo and in silico investigations 黄花菊增强7,12-二甲基苯(a)蒽诱导的大鼠宫颈细胞因子调节的治疗潜力：体内和计算机研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-22 DOI: 10.1016/j.jff.2025.106963

Putri Cahaya Situmorang , Syahputra Wibowo , Syafruddin Ilyas , Sony Eka Nugraha , Alexander Patera Nugraha , Diyah Tri Utami , Nik Mohd Afizan Nik Abd Rahman , Rizal Mukra

{"title":"Therapeutic potential of Gynura procumbens in enhancing cytokine regulation in the cervix of rats induced by 7,12-dimethylbenz(a)anthracene: In vivo and in silico investigations","authors":"Putri Cahaya Situmorang , Syahputra Wibowo , Syafruddin Ilyas , Sony Eka Nugraha , Alexander Patera Nugraha , Diyah Tri Utami , Nik Mohd Afizan Nik Abd Rahman , Rizal Mukra","doi":"10.1016/j.jff.2025.106963","DOIUrl":"10.1016/j.jff.2025.106963","url":null,"abstract":"<div><div>Cytokine dysregulation plays a central role in DMBA-induced cervical inflammation with neoplastic potential. This study investigated the effects of <em>Gynura procumbens</em> (GB) on key cytokines—IL-1β, IL-6, IL-10, and IL-18—using in vivo and in silico approaches. Female rats treated with DMBA received GB extract at 100, 200, or 300 mg/kg weight. GB at 300 mg/kg significantly suppressed IL-1β and IL-18 (<em>p</em> < 0.01) while restoring IL-10 to near-normal levels. IL-6 expression, reduced by DMBA, was upregulated following GB treatment. Histology revealed reduced epithelial damage and improved regeneration. In silico analysis showed that GB's active compounds, particularly nonanedioic and tetradecanoic acids, had higher binding affinity to IL-10 and IL-18 than cisplatin. Molecular dynamics simulations indicated enhanced protein stability, with RMSF values reduced in IL-18 (from 4.7 Å to ∼2.7 Å) and IL-10 (from 6.2 Å to ∼3.1 Å). These results support the anti-inflammatory and immunomodulatory potential of GB for cervical inflammation with neoplastic features.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106963"},"PeriodicalIF":3.8,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignan-enriched nutmeg extract changes gut microbiota associated with aging in C57BL/6 mice 富含木脂素的肉豆蔻提取物改变与C57BL/6小鼠衰老相关的肠道微生物群

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-19 DOI: 10.1016/j.jff.2025.106966

Ji-Seon Ahn , Jae Uk Kim , Je-Ho Lee , Gyung-Tae Ban , Yoosik Yoon , Hwa-Seung Yoo , Jong-Soon Choi , Hea-Jong Chung

{"title":"Lignan-enriched nutmeg extract changes gut microbiota associated with aging in C57BL/6 mice","authors":"Ji-Seon Ahn , Jae Uk Kim , Je-Ho Lee , Gyung-Tae Ban , Yoosik Yoon , Hwa-Seung Yoo , Jong-Soon Choi , Hea-Jong Chung","doi":"10.1016/j.jff.2025.106966","DOIUrl":"10.1016/j.jff.2025.106966","url":null,"abstract":"<div><div>As the aging population grows, increasing interest in promoting healthy aging through dietary interventions is growing. Gut microbiota play a key role in age-related physiological decline and longevity. We investigated whether lignan-enriched nutmeg extract (LNX) could modulate the gut microbiota of aged mice. C57BL/6 mice (27 months old) were orally administered LNX for 5 weeks and compared to young (3 months) and aged controls. LNX significantly reduced body weight without affecting food intake. 16S rRNA sequencing showed that age-related microbial shifts, including decreased <em>Firmicutes</em> and increased <em>Bacteroidota</em>, were partially reversed by LNX. While microbial diversity was unchanged, LNX increased <em>Bifidobacterium</em>, <em>Blautia</em>, and <em>Acetatifactor muris</em>, a taxon previously associated with healthy aging, and reduced <em>Turicibacter sanguinis</em>, linked to normal aging. These findings suggest that LNX modulates specific microbial taxa without broadly restoring a youthful microbiota composition.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106966"},"PeriodicalIF":3.8,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the biochemical and functional properties of water kefir: Comparative effects of different water sources with emphasis on deep ocean water 提高水开菲尔的生化和功能特性：不同水源的比较效果，重点是深海水

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-07-18 DOI: 10.1016/j.jff.2025.106965

Ji Yeon Lee , Hayeong Kim , Tae-hui Yang , Sejin Oh , Ghahyun Jeffrey Kim , Soyoung Park , Sichul Lee , Il-Kyoon Mok , Dong Hyun Kang , Doman Kim

{"title":"Enhancing the biochemical and functional properties of water kefir: Comparative effects of different water sources with emphasis on deep ocean water","authors":"Ji Yeon Lee , Hayeong Kim , Tae-hui Yang , Sejin Oh , Ghahyun Jeffrey Kim , Soyoung Park , Sichul Lee , Il-Kyoon Mok , Dong Hyun Kang , Doman Kim","doi":"10.1016/j.jff.2025.106965","DOIUrl":"10.1016/j.jff.2025.106965","url":null,"abstract":"<div><div>Water kefir has gained popularity as a traditional fermented beverage associated with various health benefits. In this study, water kefir was fermented with deionized water (DW), deep-ocean water (DOW) and natural mineral water (NMW) to compare physicochemical and health-promoting traits. DOW kefir (DOWK) reached pH 3.03 and titratable acidity 9.54 g/L, versus 3.37/1.52 g/L (DWK) and 3.69/4.46 g/L (NMWK). HPLC showed DWK contained only acetic acid (0.10 g/L), while DOWK and NMWK accumulated gluconic acid (0.26–0.31 g/L), lactic acid (0.13–0.19 g/L), and higher acetic acid (1.60–4.24 g/L). All grains bore α-1,6 glucosyl linkages. DOWK displayed the greatest antioxidant capacity and α-glucosidase inhibition, 1.13–3.51-fold above DWK/NMWK, and the strongest antibacterial action against <em>Salmonella</em>, <em>E. coli</em> and <em>S. aureus</em> (MIC 25–50 % <em>v</em>/v). DWK showed minimal inhibition. The mineral profile of DOW thus stimulates microbial metabolism and yields water kefir with superior health-related properties, supporting its use in value-added functional beverages.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"132 ","pages":"Article 106965"},"PeriodicalIF":3.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0