Journal of Functional Foods最新文献_第9页

Branched-chain amino acid metabolic disorder promotes osteoporosis by inhibiting HIF1-α-mediated glycolytic reprogramming in osteoblasts 支链氨基酸代谢紊乱通过抑制HIF1-α-介导的成骨细胞糖酵解重编程促进骨质疏松

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-15 DOI: 10.1016/j.jff.2025.106885

Xintong Xie , Xue Zhang , Guangliang Wei , Xiping Zhou , Huidong Chen , Zhenboyang Tang , Xiru Lin , Chunyan Huang , Jiqiang Wu , Ping Wang , Chengsong He , Yue He , Jie Chen

{"title":"Branched-chain amino acid metabolic disorder promotes osteoporosis by inhibiting HIF1-α-mediated glycolytic reprogramming in osteoblasts","authors":"Xintong Xie , Xue Zhang , Guangliang Wei , Xiping Zhou , Huidong Chen , Zhenboyang Tang , Xiru Lin , Chunyan Huang , Jiqiang Wu , Ping Wang , Chengsong He , Yue He , Jie Chen","doi":"10.1016/j.jff.2025.106885","DOIUrl":"10.1016/j.jff.2025.106885","url":null,"abstract":"<div><div>Osteoporosis is the leading cause of fractures in the elderly, and metabolic changes, including elevated levels of branched-chain amino acids (BCAAs), have been implicated in its pathogenesis. This study explores the impact of high BCAAs levels on bone health. After feeding mice a diet containing twice the normal BCAAs levels for six months, serum BCAAs levels were elevated, and trabecular bone density decreased. In vivo experiments revealed that high concentrations of BCAAs adversely affected the microstructure of bone in mice, and further targeted metabolomics analysis suggested impaired energy metabolism, potentially associated with “carbohydrate digestion and absorption,” “starch and sucrose metabolism,” and “riboflavin metabolism.” In vitro experiments showed that BCAAs inhibited the proliferation, osteogenic differentiation, and glycolysis of MC3T3-E1 cells, possibly through the regulation of HIF-1α and GLUT1. Excessive BCAAs may reduce bone mass and increase the risk of osteoporosis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106885"},"PeriodicalIF":3.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of ginseng supplementation and health outcomes: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials 人参补充剂对健康结果的影响：一项grade评价的随机对照试验的系统评价和荟萃分析

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-14 DOI: 10.1016/j.jff.2025.106879

Xu Huang , Mahdi Daneshi , Maryam Falahatzadeh , Mahsa Rounagh

{"title":"The effect of ginseng supplementation and health outcomes: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials","authors":"Xu Huang , Mahdi Daneshi , Maryam Falahatzadeh , Mahsa Rounagh","doi":"10.1016/j.jff.2025.106879","DOIUrl":"10.1016/j.jff.2025.106879","url":null,"abstract":"<div><div>Ginseng, a widely used herbal remedy, has been proposed to possess cardiometabolic benefits. However, the findings regarding its effects on health outcomes remain inconsistent. This meta-analysis aimed to assess ginseng supplementation's impact on health outcomes. A comprehensive literature search was conducted across multiple databases to identify RCTs evaluating the effect of ginseng supplementation. Forty-four RCTs encompassing 56 intervention arms were included. Ginseng supplementation significantly reduced IL-6 levels (WMD = −2.03 pg/mL; 95 % CI: −3.12 to −0.93; <em>p</em> < 0.001). No significant effects were observed on body weight (WMD = −0.52 kg; 95 % CI: −1.47 to 0.44), BMI (WMD = −0.035 kg/m<sup>2</sup>; 95 % CI: −0.148 to 0.079), waist circumference, systolic or diastolic blood pressure, or lipid profiles including total cholesterol, triglycerides, HDL-C, and LDL-C. The beneficial effects of ginseng supplementation on SBP and DBP were shown after sensitivity analysis. Ginseng supplementation may improve inflammatory profiles by lowering IL-6 and enhancing adiponectin, but it does not appear to significantly influence anthropometric measures, and lipid profiles. Further well-designed, long-term trials are warranted.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106879"},"PeriodicalIF":3.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herbs and spices as functional food ingredients: A comprehensive review of their therapeutic properties, antioxidant and antimicrobial activities, and applications in food preservation 草药和香料作为功能性食品配料：其治疗特性、抗氧化和抗菌活性及其在食品保鲜中的应用的综合综述

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-13 DOI: 10.1016/j.jff.2025.106882

Nasser Al-Habsi , Maha Al-Khalili , Syed Ariful Haque , Nada Al Akhzami , Cid R. Gonzalez-Gonzalez , Sheikha Al Harthi , Saud M. Al Jufaili

{"title":"Herbs and spices as functional food ingredients: A comprehensive review of their therapeutic properties, antioxidant and antimicrobial activities, and applications in food preservation","authors":"Nasser Al-Habsi , Maha Al-Khalili , Syed Ariful Haque , Nada Al Akhzami , Cid R. Gonzalez-Gonzalez , Sheikha Al Harthi , Saud M. Al Jufaili","doi":"10.1016/j.jff.2025.106882","DOIUrl":"10.1016/j.jff.2025.106882","url":null,"abstract":"<div><div>The utilization of herbs and spices dates back thousands of years. They are mainly used as preservatives, flavour enhancers, colourants, fragrances, and therapeutic substances. Currently, a multitude of medications are derived from these botanicals and seasonings. This review will focus on the direct use of herbs and spices to treat and cure ailments. The health benefits of herbs and spices are attributed to their active chemicals, including antioxidants, anti-inflammatory agents, antibacterials, and others. Thus, incorporating herbs and spices into food products offers substantial advantages in terms of functionality and provides medicinal and nutritional benefits. This review aims to provide a concise overview of the characteristics of herbs and spices during the past decade. It will cover their medicinal, antioxidant, antimicrobial, and sensory capabilities and their uses in dairy products. Herbs and spices are a superior alternative to synthetic preservatives in fortifying foods, as they enhance the products' visual appeal and desirability while extending their shelf life. Further research is required to optimize the extraction of active chemicals, explore the synergistic effects of different herbs and spices, conduct more clinical trials, and enhance formulation development for functional foods and natural preservatives.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106882"},"PeriodicalIF":3.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the effect and mechanisms of Zhi-Zi-Chi-Tang on the cognitive dysfunction in db/db mice 益智益智汤对db/db小鼠认知功能障碍的影响及机制研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-13 DOI: 10.1016/j.jff.2025.106886

Jinsong Deng , Jianguang Sun , Chang Peng , Ming Yang , Zhenchao Wang , Yonghong Liang , Haiyan Zhang

{"title":"Study of the effect and mechanisms of Zhi-Zi-Chi-Tang on the cognitive dysfunction in db/db mice","authors":"Jinsong Deng , Jianguang Sun , Chang Peng , Ming Yang , Zhenchao Wang , Yonghong Liang , Haiyan Zhang","doi":"10.1016/j.jff.2025.106886","DOIUrl":"10.1016/j.jff.2025.106886","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) accompanied by cognitive dysfunction poses a significant burden to public health and social economic. Zhi-Zi-Chi-Tang (ZZCT), a traditional Chinese medicine formula, which consists of two edible herbs, Fructus gardenia and fermented soybean, has been reported to exhibit benefits on glucolipid disorders and neuro disorders. However, its effect and mechanisms on T2DM-related cognitive dysfunction remain to be illustrated. To this purpose, the present study utilized T2DM model (db/db) mice. Homeostasis model assessment for insulin resistance (HOMA-IR) indices, oral glucose tolerance test, and blood lipid levels were determined. Morris water maze (MWM) test, histological stanning, mRNA sequencing, qRT-PCR, Western blotting, and immunohistochemistry et al. assays were conducted. Results showed that ZZCT improved HOMA-IR, OGTT, spatial learning and memory, reduced lipid levels, mitigated tissue lesions, activated proteins, reduced neuroinflammation, and enhanced neuroplasticity in db/db mice. In conclusion, ZZCT alleviates cognitive dysfunction in db/db mice through multiple mechanisms.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106886"},"PeriodicalIF":3.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the Longan pulp and seed extract beverage product on bone turnover markers, lipid profiles, glycemic markers, and safety profiles in the elderly: A randomized, double-blind, placebo-controlled trial 龙眼果肉籽提取物饮料产品对老年人骨转换指标、血脂、血糖指标和安全性的影响：一项随机、双盲、安慰剂对照试验

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106887

Mingkwan Na Takuathung , Kornvipa Settakorn , Jakkrit Aisara , Nahathai Dukaew , Ratchanon Inpan , Jeeraporn Chitphan , Preeyaporn Klinjan , Tattiya Kantasa , Kantirat Yaja , Wichaya Karat , Nut Koonrungsesomboon

{"title":"Effects of the Longan pulp and seed extract beverage product on bone turnover markers, lipid profiles, glycemic markers, and safety profiles in the elderly: A randomized, double-blind, placebo-controlled trial","authors":"Mingkwan Na Takuathung , Kornvipa Settakorn , Jakkrit Aisara , Nahathai Dukaew , Ratchanon Inpan , Jeeraporn Chitphan , Preeyaporn Klinjan , Tattiya Kantasa , Kantirat Yaja , Wichaya Karat , Nut Koonrungsesomboon","doi":"10.1016/j.jff.2025.106887","DOIUrl":"10.1016/j.jff.2025.106887","url":null,"abstract":"<div><div>Aging disrupts bone remodeling and metabolism, adversely affecting the quality of life. Longan, a tropical fruit rich in bioactive compounds, has demonstrated benefits for bone metabolism, lipid lowering, and glycemic control. This study evaluated the effects of a longan pulp and seed extract beverage (LON) product on bone turnover markers, lipid profiles, glycemic markers, and safety in the elderly. In a 12-week randomized, double-blind, placebo-controlled trial, 50 participants (aged 55–75 years) consumed either LON or a placebo (PLA). After 12 weeks, ALP levels significantly differed between groups (mean difference: -7.06 U/L; 95 % CI: −13.08 to −1.03; <em>p</em> = 0.023), with a reduction in the LON group and an increase in the PLA group. Other bone turnover markers showed favorable trends, while lipid and glycemic markers remained unchanged. No serious adverse events or safety concerns were observed. In conclusion, LON is safe and well-tolerated and may support bone health while maintaining metabolic stability in the elderly.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106887"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidation of the mechanism of the fruit of Rubus chingii Hu against CCl4-induced liver injury in mice based on met/Tlr2/Tlr4 -mediated PI3K-Akt signaling pathway 基于met/Tlr2/Tlr4介导的PI3K-Akt信号通路阐明青藤果抗ccl4诱导小鼠肝损伤的机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106884

Ping Jiang , Yanfei He , Guangpei Xu , Chuanbo Sun

引用次数: 0

Silkworm pupa powder alleviates metabolic dysfunction-associated steatotic liver disease by regulating microbial-intestinal-liver axis and TLR4 / MyD88 / NF-κB signaling pathway 蚕蛹粉通过调节微生物-肠-肝轴和TLR4 / MyD88 / NF-κB信号通路，缓解代谢功能障碍相关的脂肪变性肝病

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106892

Yan Chen , Feng Li , Yan Bai , Qishi Che , Hua Cao , Jiao Guo , Zhengquan Su

{"title":"Silkworm pupa powder alleviates metabolic dysfunction-associated steatotic liver disease by regulating microbial-intestinal-liver axis and TLR4 / MyD88 / NF-κB signaling pathway","authors":"Yan Chen , Feng Li , Yan Bai , Qishi Che , Hua Cao , Jiao Guo , Zhengquan Su","doi":"10.1016/j.jff.2025.106892","DOIUrl":"10.1016/j.jff.2025.106892","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease globally, but effective treatment strategies remain limited. Silkworm pupa powder (SP), the first approved insect food in China, protect the liver, but its effect on metabolic dysfunction-associated steatotic liver disease (MASLD) is unknown. This study explored SP's impact on MASLD in C57BL/6 J mice fed a high-fat diet (HFD) for 8 weeks, then treated with SP and metformin for 12 weeks. We found that SP could improve body weight, lipid levels, insulin resistance and the oxidation-antioxidant balance. SP reduces liver lipid deposition by lowering liver inflammation (down-regulating the TLR4 / MyD88 / NF-κB inflammatory pathway) and reshaping the gut microbiome to regulate bile acid metabolism. These findings collectively suggest that SP alleviates MASLD by regulating gut microbiota-bile acid metabolism and inhibiting TLR4-mediated liver inflammation, making it a promising functional food for metabolic liver diseases.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106892"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EPA-enriched sulfoquinovosyldiacylglycerol attenuates inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages 富含epa的磺基喹烷基二酰基甘油减轻脂多糖刺激的RAW264.7巨噬细胞的炎症

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106888

Lei Lü , Xiao-Yun Li , Qing-Yan Zou , Jin-Xing He , Han-Zhu Xing , Kazuo Miyashita , Yu-Hong Yang , Lei Du

{"title":"EPA-enriched sulfoquinovosyldiacylglycerol attenuates inflammation in lipopolysaccharide-stimulated RAW264.7 macrophages","authors":"Lei Lü , Xiao-Yun Li , Qing-Yan Zou , Jin-Xing He , Han-Zhu Xing , Kazuo Miyashita , Yu-Hong Yang , Lei Du","doi":"10.1016/j.jff.2025.106888","DOIUrl":"10.1016/j.jff.2025.106888","url":null,"abstract":"<div><div>The marine diatom <em>Phaeodactylum tricornutum</em> contains a diverse range of structurally unique bioactive compounds, such as eicosapentaenoic acid-enriched sulfoquinovosyldiacylglycerol (EPA-SQDG). The present study aimed to elucidate the anti-inflammatory role and the underlying mechanisms of EPA-SQDG in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The results demonstrated that EPA-SQDG dose-dependently suppressed LPS-induced overexpression of pro-inflammatory molecules in RAW264.7 macrophages, including NO, iNOS, COX-2, TNF-<em>α</em>, IL-1<em>β</em>, and IL-6. Additionally, EPA-SQDG notably blocked LPS-induced degradation of I<em>κ</em>B<em>α</em> and nuclear translocation of NF-<em>κ</em>B. Moreover, EPA-SQDG markedly inhibited the phosphorylation of ERK 1/2, JNK, and p38 MAPKs. Furthermore, EPA-SQDG significantly reduced the intracellular ROS generation, and enhanced the nuclear Nrf2 protein levels, and HO-1 expression in LPS-stimulated RAW264.7 macrophages. These findings collectively suggest that EPA-SQDG exerts potent anti-inflammatory effect through coordinated modulation the NF-<em>κ</em>B, MAPKs, and Nrf2/HO-1 signaling pathways, highlighting its potential as a functional ingredient for prevention and treatment of inflammatory diseases.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106888"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silkworm pupae extract attenuates diabetic kidney disease through inhibiting apoptosis 蚕蛹提取物通过抑制细胞凋亡减轻糖尿病肾病

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106881

Zhixuan Xie , Luping Wang , Binqi Wang , Xueli Man , Yifei Wang , Taian Jin , Jiahui Ma , Eman Shawky , Samah Elsohafy , Tingfang Ma , Jianhua Li , Juan Jin , Qiang He , Jingkui Tian

{"title":"Silkworm pupae extract attenuates diabetic kidney disease through inhibiting apoptosis","authors":"Zhixuan Xie , Luping Wang , Binqi Wang , Xueli Man , Yifei Wang , Taian Jin , Jiahui Ma , Eman Shawky , Samah Elsohafy , Tingfang Ma , Jianhua Li , Juan Jin , Qiang He , Jingkui Tian","doi":"10.1016/j.jff.2025.106881","DOIUrl":"10.1016/j.jff.2025.106881","url":null,"abstract":"<div><div>Diabetic kidney disease (DKD), a prevalent microvascular complication affecting over 40 % of diabetes patients globally, imposes substantial burdens on healthcare systems through its dual impact on renal function deterioration and cardiovascular mortality. Silkworm pupae (SWP) is an ancient functional food documented in Chinese Materia Medica and Southeast Asian dietary practices, has recently emerged as a research focus due to its unique composition of chitin-derived peptides, antioxidant flavonoids, and angiotensin-converting enzyme inhibitory components. Building upon existing evidence of SWP's anti-inflammatory properties, this investigation evaluated the renoprotective effects of SWP in two representative stages—C2 (the fragile and soft stage) and C4 (nearly eclosion). The results indicated that SWP alleviated renal dysfunction and renal fibrosis through inhibiting apoptosis in DM mice. Notably, C2-stage extracts outperformed C4 counterparts in restoring podocyte integrity. These findings position SWP as a nutraceutical intervention for DKD management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106881"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on the activity of Astragalus honey on blood glucose, immunity, and intestinal microorganisms in the organism 黄芪蜂蜜对机体血糖、免疫及肠道微生物活性的研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-12 DOI: 10.1016/j.jff.2025.106877

Leilei Xie , Rongrong Luo , Xiaoyu Shen , Wenhui Wang , Yangang Cheng , Yingli Wang , Yan Wang

{"title":"Studies on the activity of Astragalus honey on blood glucose, immunity, and intestinal microorganisms in the organism","authors":"Leilei Xie , Rongrong Luo , Xiaoyu Shen , Wenhui Wang , Yangang Cheng , Yingli Wang , Yan Wang","doi":"10.1016/j.jff.2025.106877","DOIUrl":"10.1016/j.jff.2025.106877","url":null,"abstract":"<div><div>This study aimed to investigate the effects of Astragalus honey (ASH) on blood glucose levels, immunity function, and intestinal microbiota, while exploring its potential mechanisms of action using metabolomics. The results showed that ASH did not cause excessive elevation in blood glucose levels or induce a glucose burden. Immunological analysis revealed that NK cell activity, splenic T-lymphocyte proliferation and Phagocytic activity of macrophages were significantly increased in the high-dose ASH group. Analysis of intestinal flora showed that ASH increased the relative abundance of Clostridium, Anaplasma, Anaplasma paraphyllum and Eucalyptus species. Serum metabolomics indicated that ASH exerted its effects by modulating pathways such as primary bile acid biosynthesis, arachidonic acid metabolism, glycerophospholipid metabolism, and retinol metabolism. PCR results demonstrated that ASH upregulated PEMT and LCAT gene expression in the glycerophospholipid metabolic pathway. ASH does not impose a glucose burden, enhances immune function, and modulates intestinal flora.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106877"},"PeriodicalIF":3.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0