Journal of Functional Foods最新文献_第9页

Lyophilized Bryndza cheese capsules increase butyrate-producing gut bacteria in recreational athletes: A randomized controlled trial 冻干Bryndza奶酪胶囊增加休闲运动员产生丁酸盐的肠道细菌：一项随机对照试验

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1016/j.jff.2025.107139

Ivan Hric , Libuša Nechalová , Miroslava Šimiaková , Eva Baranovičová , Galal Ali Esmail , Riadh Hammami , Adela Penesová , Viktor Bielik

{"title":"Lyophilized Bryndza cheese capsules increase butyrate-producing gut bacteria in recreational athletes: A randomized controlled trial","authors":"Ivan Hric , Libuša Nechalová , Miroslava Šimiaková , Eva Baranovičová , Galal Ali Esmail , Riadh Hammami , Adela Penesová , Viktor Bielik","doi":"10.1016/j.jff.2025.107139","DOIUrl":"10.1016/j.jff.2025.107139","url":null,"abstract":"<div><div>Bryndza, a traditional sheep cheese from Eastern Europe, is a natural source of probiotic lactic acid bacteria (LAB). This study investigated the effects of encapsulated bryndza probiotic capsules on the gut microbiome and metabolome of young athletes. Recreational runners (<em>n</em> = 26 experimental; <em>n</em> = 18 control) completed an 8-week intervention. Participants in the experimental group consumed Bryndza capsules. Stool samples and body composition were collected before and after intervention. Microbiota composition was analyzed by 16S rRNA gene sequencing, and fecal metabolites were measured using nuclear magnetic resonance spectroscopy. Bryndza capsules contained viable LAB, including <em>Lacticaseibacillus paracasei</em>, <em>Lactococcus lactis</em>, <em>Leuconostoc mesenteroides</em>, and <em>Enterococcus</em> species. No changes in body composition were observed. In the experimental group, butyrate-producing bacteria, such as <em>Anaerostipes hadrus</em>, <em>Eubacterium ventriosum</em>, and <em>Faecalibacterium prausnitzii</em>, increased significantly. Our findings indicate that lyophilized and encapsulated Bryndza retains probiotic activity and positively modulates the gut microbiome, particularly by enhancing butyrate-producing bacteria.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107139"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chinese bayberry (Morella rubra Lour.) seed improves DSS-induced inflammatory bowel disease by inhibiting inflammation and oxidative stress 杨梅种子通过抑制炎症和氧化应激改善dss诱导的炎症性肠病

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2025-12-15 DOI: 10.1016/j.jff.2025.107123

Dan Long , Huan Zhao , Xia Wu , Lu Jin , Yuanquan Ran , Qiong Hu , Xiaoqing Zhao , Tian Zhang , Minyi Tian

{"title":"Chinese bayberry (Morella rubra Lour.) seed improves DSS-induced inflammatory bowel disease by inhibiting inflammation and oxidative stress","authors":"Dan Long , Huan Zhao , Xia Wu , Lu Jin , Yuanquan Ran , Qiong Hu , Xiaoqing Zhao , Tian Zhang , Minyi Tian","doi":"10.1016/j.jff.2025.107123","DOIUrl":"10.1016/j.jff.2025.107123","url":null,"abstract":"<div><div>This study investigated the phytochemical characteristics and first explored its anti-inflammatory action related to IBD of Chinese bayberry (<em>Morella rubra</em> Lour.) seed. High total phenolic and flavonoid contents were found in its 70 % ethanol (EE) and water extracts (WE). Besides, 83 substances comprising 12 flavonoids and 26 phenolic compounds were identified. In LPS-stimulated RAW264.7 macrophages, EE demonstrated a more pronounced inhibitory effect on the excess inflammatory factor production (IL-1β, IL-6, PGE₂, NO, and TNF-α) in comparison to WE and significantly suppressed the ROS overproduction and LPS-activated MAPK and NF-κB pathways. In a DSS-induced mouse IBD model, EE effectively ameliorated the colonic histopathological lesions and pathological symptoms of diarrhea, weight loss, and hematochezia. Additionally, EE mitigated oxidative stress (by elevating SOD/CAT activity and reducing MDA content) and inflammation (by depressing IL-6, IL-1β, and TNF-α levels) in serum and tissues. These findings suggest that Chinese bayberry seed possesses anti-inflammatory properties relevant to IBD, indicating its potential application in functional foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107123"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pure honey candy wrapped in nori (Phorphyra spp.): Innovative low-temperature processing to enhance antioxidant activity and immunomodulatory effects 紫菜包裹纯蜂蜜糖：创新低温加工，增强抗氧化活性和免疫调节作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1016/j.jff.2025.107129

Andi Nilawati Usman , Risfah Yulianty , Andi Ariyandy , Burhan Basaran , Muhammad Tamar , Fendi Fendi

{"title":"Pure honey candy wrapped in nori (Phorphyra spp.): Innovative low-temperature processing to enhance antioxidant activity and immunomodulatory effects","authors":"Andi Nilawati Usman , Risfah Yulianty , Andi Ariyandy , Burhan Basaran , Muhammad Tamar , Fendi Fendi","doi":"10.1016/j.jff.2025.107129","DOIUrl":"10.1016/j.jff.2025.107129","url":null,"abstract":"<div><div>Honey, which is considered as a functional food, is rich in bioactive compounds. This study aimed to create a pure honey candy from <em>Apis dorsata</em> honey using low-temperature processing and nori wrapping to boost nutritional stability. Three drying methods were evaluated: dehydrator, oven, and air fryer. The oven method (40 °C for 10 h and then 60 °C for 38 h) optimally preserved antioxidant activity, with the lowest IC<sub>50</sub> value; thus, it was chosen for final production. Nori wrapping significantly increased protein and flavonoid contents while reducing hydroxymethylfurfural and sugar levels. A pilot intervention where homemakers and toddlers consumed 15 g of nori-wrapped honey candy daily for 7 days showed significant increases in Foxp3 (immune biomarker), reduced fatigue, and improved sleep. Cortisol and estrogen levels were slightly, but not significantly, modulated. These findings indicate that nori-wrapped honey candy is an innovative functional food with promising immunomodulatory and health-promoting benefits, particularly for stress- and fatigue-prone populations.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107129"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and mechanisms of flavonoids in the prevention and treatment of osteoporosis: with an emphasis on the role of gut flora 黄酮类化合物在预防和治疗骨质疏松症中的作用和机制：重点关注肠道菌群的作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2025-12-18 DOI: 10.1016/j.jff.2025.107136

Mengyao Song , Xilong Liu , Di Ma , Yiming Pan , Xinqi Liu , Lu Li

引用次数: 0

Immunonutrients as modulators of inflammation, barrier integrity, and immune regulation: Toward precision nutrition 免疫营养素作为炎症、屏障完整性和免疫调节的调节剂：走向精准营养

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107119

Aminah Dalimunthe , Michle William Tan , Felice Chrismary Lu , Yumiko Angiosaki , Andi Nilawati Usman , Sony Eka Nugraha , Mahani Mahani , Princella Halim , Yuandani , Fahrul Nurkolis , Amer Ahmed , Nurpudji Astuti Taslim , Mega Carensia Gunawan , Arya Tjipta Prananda , Chindy Umaya , Rony Abdi Syahputra

{"title":"Immunonutrients as modulators of inflammation, barrier integrity, and immune regulation: Toward precision nutrition","authors":"Aminah Dalimunthe , Michle William Tan , Felice Chrismary Lu , Yumiko Angiosaki , Andi Nilawati Usman , Sony Eka Nugraha , Mahani Mahani , Princella Halim , Yuandani , Fahrul Nurkolis , Amer Ahmed , Nurpudji Astuti Taslim , Mega Carensia Gunawan , Arya Tjipta Prananda , Chindy Umaya , Rony Abdi Syahputra","doi":"10.1016/j.jff.2025.107119","DOIUrl":"10.1016/j.jff.2025.107119","url":null,"abstract":"<div><div>Immunonutrient has emerged as a critical discipline integrating immunology, nutrition, and precision medicine. Key immunonutrients—including omega-3 fatty acids, vitamins D, C, and E, zinc, selenium, glutamine, arginine, polyphenols, and probiotics—modulate innate and adaptive immunity through mechanisms involving cytokine regulation, barrier function enhancement, immune cell differentiation, and redox balance. Multi-omics technologies have revealed substantial inter-individual variability in nutrient-immune interactions, driven by genetic polymorphisms, metabolic phenotypes, and microbiome composition. Clinical evidence demonstrates that immunonutrients reduce inflammatory markers, lower infection rates, and improve outcomes in surgical, critical care, autoimmune, and infectious disease contexts. Maternal and pediatric immunonutrient influences lifelong immune competence through developmental programming. However, challenges persist in defining optimal dosages, evaluating nutrient synergies, and translating precision nutrition into clinical practice. This review highlights the integration of genomics, metabolomics, and artificial intelligence to enable individualized immunonutrient interventions. By moving beyond population-based recommendations, precision immunonutrient represents a cornerstone of personalized healthcare with potential to optimize immune resilience across diverse clinical populations. This review synthesizes current evidence on the molecular mechanisms by which key immunonutrients modulate immune responses and explores how precision nutrition frameworks can translate inter-individual variability into personalized therapeutic strategies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107119"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic effects and mechanisms of animal-derived blood peptides in C2C12 myotubes and alloxan-induced diabetic mice 动物源性血肽在C2C12肌管和四氧嘧啶诱导的糖尿病小鼠中的降糖作用及其机制

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107134

Gui'e Hu , Yebi Qin , Mei Qu , Jingwei Jin , Panpan Wu , Lishe Gan , Dongli Li

{"title":"Hypoglycemic effects and mechanisms of animal-derived blood peptides in C2C12 myotubes and alloxan-induced diabetic mice","authors":"Gui'e Hu , Yebi Qin , Mei Qu , Jingwei Jin , Panpan Wu , Lishe Gan , Dongli Li","doi":"10.1016/j.jff.2025.107134","DOIUrl":"10.1016/j.jff.2025.107134","url":null,"abstract":"<div><div>This study aimed to elucidate the hypoglycemic effects and mechanisms of animal-derived blood peptide protein powder (BPPP). BPPP dose-dependently increased glucose uptake in C2C12 myotubes (100, 200, 400 μg/mL) without compromising cell viability. Mechanistically, BPPP activated the insulin signaling pathway and promoted GLUT4 membrane translocation. Four-week BPPP gavage ameliorated diabetic symptoms in alloxan-induced mice, significantly lowering fasting glucose, improving glucose tolerance, and attenuating tissue damage. Moreover, BPPP enhanced hepatic antioxidant capacity and improved dyslipidemia in diabetic mice. Consistent with the <em>in vitro</em> experiments, BPPP upregulated the insulin signaling pathway and GLUT4 expression in skeletal muscle. Additionally, BPPP suppressed hepatic gluconeogenesis (PEPCK, G6Pase) while enhancing glycogen storage. LC-MS/MS analysis of BPPP-G1 and BPPP-G2 fractions identified three non-toxic bioactive peptides (YPWTQ, VDPENFRLL, RYVDPENFRLL), which were validated by Peptide Ranker and molecular docking. These findings provide a theoretical basis for BPPP application as a functional food ingredient or therapeutic agent in diabetes management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107134"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01

引用次数: 0

Alleviative effect of Lueyang black-bone chicken liver peptides on dextran sodium sulfate-induced ulcerative colitis in mice 六羊乌骨鸡肝肽对右旋糖酐硫酸钠诱导小鼠溃疡性结肠炎的缓解作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107145

Jincheng Xi , Shanshan Wang , Ruixue Wang , Ling Wang , Hongzhao Lu , Tao Zhang , Wenxian Zeng

{"title":"Alleviative effect of Lueyang black-bone chicken liver peptides on dextran sodium sulfate-induced ulcerative colitis in mice","authors":"Jincheng Xi , Shanshan Wang , Ruixue Wang , Ling Wang , Hongzhao Lu , Tao Zhang , Wenxian Zeng","doi":"10.1016/j.jff.2025.107145","DOIUrl":"10.1016/j.jff.2025.107145","url":null,"abstract":"<div><div>Ulcerative colitis (UC), an inflammatory bowel disease with long-term medication side effects, requires safe therapies. Lueyang black-bone chicken liver peptides (BLP) were prepared by hydrolyzing its liver with 1 % alkaline protease for 1 h. Peptides with a molecular weight of less than 1.5 kDa account for 77.6 %. The hydrophobic and basic amino acids of BLP accounted for 47.20 % and 11.75 %, respectively. In dextran sulfate sodium (DSS)-induced UC mice, BLP increased body weight, reduced DAI scores, restored colon length, ameliorated tissue damage, decreased inflammatory cytokines, and upregulated tight junction proteins (claudin-1, occludin and ZO-1). Meanwhile, BLP increased the abundance of probiotics (<em>Akkermansia</em>, <em>Dubosiella, Coriobacteriaceae_</em>UCG-002, and <em>Bifidobacterium</em>). Among them, <em>Akkermansia</em> promoted the synthesis of key metabolites, such as 5-hydroxyindole-3-acetic acid, picolinic acid, prostaglandin D2, lipoxin A4 and chenodeoxycholic acid, thereby alleviating UC. This study provides a new evidence for UC relief and a basis for high-value utilization of chicken liver.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107145"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of fermentation by cholesterol-lowering fungi on the functional components and bioactive properties of kiwifruit pomace 降胆固醇真菌发酵对猕猴桃果渣功能成分及生物活性的影响

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107128

Ang Liu , Jiang-yong Hong , Fei Huang , Bo-yu Dong , Qiu-ping Yao , De-quan Zhu

{"title":"The effects of fermentation by cholesterol-lowering fungi on the functional components and bioactive properties of kiwifruit pomace","authors":"Ang Liu , Jiang-yong Hong , Fei Huang , Bo-yu Dong , Qiu-ping Yao , De-quan Zhu","doi":"10.1016/j.jff.2025.107128","DOIUrl":"10.1016/j.jff.2025.107128","url":null,"abstract":"<div><div>Kiwifruit pomace, a processing byproduct with lipid metabolism-regulating potential, is often discarded because of its low bioavailability. In this study, fungal fermentation, which is an efficient bioprocessing strategy, was applied to increase the contents of its active components and its bioavailability. Seven cholesterol-lowering fungal strains isolated from fermented foods—<em>Talaromyces</em> sp. FR, <em>Aspergillus</em> sp. C1YC, <em>Fusarium solani</em> A4YC, <em>Alternaria alstroemeriae</em> C2SLB, <em>Monascus purpureus</em> HQM, <em>Penicillium rubens</em> C3SLB, and <em>Penicillium chrysogenum</em> C2YC—were used for pomace fermentation. The contents of flavonoids, total phenolics, and soluble dietary fibre significantly increased (<em>P</em> < 0.05), with the greatest increases (1.94-, 1.42-, and 1.31-fold, respectively) observed in the HQM group. All the strains and fermented pomace extracts exhibited considerable cholesterol-degrading ability, reaching 74.79 % with the HQM suspension. Extracts of C1YC and C3SLB showed prominent antioxidant capacity, whereas the HQM extract strongly bound bile salts. α-Glucosidase activity and α-amylase activity were inhibited by the C2YC and HQM suspensions (84.84 % and 83.01 %, respectively). Compared with the control, the FR-fermented pomace adsorbed 6.01 times more fat. This study is the first to report direct cholesterol degradation by <em>Talaromyces</em> sp., <em>Fusarium solani</em>, and <em>Alternaria alstroemeriae</em>, confirming that fungal fermentation increases the value of kiwifruit pomace.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107128"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-obesity effects of fucoxanthin and conjugated linoleic acid complex liposomes in high-fat diet mice through regulation of AMPK signaling pathway 岩藻黄素和共轭亚油酸复合脂质体通过调节AMPK信号通路对高脂饮食小鼠的抗肥胖作用

IF 4 2区农林科学

Journal of Functional Foods Pub Date : 2026-01-01 Epub Date: 2026-01-06 DOI: 10.1016/j.jff.2025.107142

Jiyan Sun , Yanxiaofan Sun , Yuxin Shi , Xuhui Lei , Zhiying Xu , Yichao Ma , Shu Liu , Yunhai He , Qiukuan Wang , Dandan Ren

{"title":"Anti-obesity effects of fucoxanthin and conjugated linoleic acid complex liposomes in high-fat diet mice through regulation of AMPK signaling pathway","authors":"Jiyan Sun , Yanxiaofan Sun , Yuxin Shi , Xuhui Lei , Zhiying Xu , Yichao Ma , Shu Liu , Yunhai He , Qiukuan Wang , Dandan Ren","doi":"10.1016/j.jff.2025.107142","DOIUrl":"10.1016/j.jff.2025.107142","url":null,"abstract":"<div><div>Solving the problem of obesity has been globally recognized as a crucial public health challenge. Recent studies have shown that fucoxanthin and conjugated linoleic acid could work together to exert an anti-obesity effect. In this study, sodium alginate- and chitosan-modified fucoxanthin and conjugated linoleic acid complex liposome (S-C-L) was prepared and characterized. The anti-obesity effect and mechanism of action of S-C-L were evaluated by establishing an obese mouse model. The results indicated that S-C-L reduced the weight and fat content of obese mice and improved their oxidative stress state. It regulated the expression levels of mRNA and protein by activating the AMPK signaling pathway, thereby enhancing energy expenditure and inhibiting the differentiation of adipocytes, confirming its anti-obesity properties. Comprehensive analysis indicated that S-C-L had broad application potential in the development of anti-obesity foods and health products.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"136 ","pages":"Article 107142"},"PeriodicalIF":4.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0