Journal of Functional Foods最新文献_第9页

Latilactobacillus sakei LB-P5 ameliorates high-fat diet induced obesity by reducing lipid accumulation, enhancing thermogenesis, and restoring intestinal integrity 清酒乳杆菌 LB-P5 通过减少脂质积累、促进产热和恢复肠道完整性来改善高脂饮食诱发的肥胖症

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-29 DOI: 10.1016/j.jff.2025.106738

Won Jun Kim, Mikyung Song, Jaeseok Shim, Kyoungsub Song

{"title":"Latilactobacillus sakei LB-P5 ameliorates high-fat diet induced obesity by reducing lipid accumulation, enhancing thermogenesis, and restoring intestinal integrity","authors":"Won Jun Kim, Mikyung Song, Jaeseok Shim, Kyoungsub Song","doi":"10.1016/j.jff.2025.106738","DOIUrl":"10.1016/j.jff.2025.106738","url":null,"abstract":"<div><div>Obesity, characterized by excessive fat accumulation and metabolic dysfunction, is closely linked to gut health and systemic inflammation. This study investigates the anti-obesity effects of <em>Latilactobacillus sakei</em> LB-P5 in a high-fat diet (HFD)-induced obese mouse model. Supplementation with <em>L</em>. <em>sakei</em> LB-P5 reduced body weight gain, adipose tissue mass, and plasma lipid levels. Additionally, <em>L. sakei</em> LB-P5 improved liver function by decreasing lipid droplet accumulation and lowering liver enzyme markers (ALT, AST), alleviating liver steatosis. Gene expression analysis revealed enhanced thermogenesis via upregulation of <em>Ucp1</em> and <em>Pgc1α</em> in adipose tissue, improved insulin sensitivity, and downregulation of inflammation-related genes in both liver and adipose tissue. <em>L. sakei</em> LB-P5 also restored intestinal integrity by upregulating tight junction proteins and reducing macrophage infiltration in the intestinal epithelium. Overall, this study highlights the therapeutic potential of <em>L.</em> <em>sakei</em> LB-P5 in managing obesity through thermogenesis, gut-liver axis modulation, and systemic inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106738"},"PeriodicalIF":3.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The interplay between trace element zinc and chronic liver diseases: Still water run deep 微量元素锌与慢性肝病的相互作用：静水流深

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-29 DOI: 10.1016/j.jff.2025.106784

Xuqian Zhang , Yifan Gong , Chao Sun

引用次数: 0

Application of prebiotic stachyose on metabolic diseases and other human diseases through regulation of gut microbiota 通过调节肠道微生物群，应用益生元水苏糖治疗代谢性疾病和其他人类疾病

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-29 DOI: 10.1016/j.jff.2025.106778

Ziheng Zhang , Jiajing Wu , Zishuai Zhang , Shuhan Liu , Zizhen Yang , Jingyi Wang , Yanan Liu , Shangyong Li , Ningning He , Ning Li

{"title":"Application of prebiotic stachyose on metabolic diseases and other human diseases through regulation of gut microbiota","authors":"Ziheng Zhang , Jiajing Wu , Zishuai Zhang , Shuhan Liu , Zizhen Yang , Jingyi Wang , Yanan Liu , Shangyong Li , Ningning He , Ning Li","doi":"10.1016/j.jff.2025.106778","DOIUrl":"10.1016/j.jff.2025.106778","url":null,"abstract":"<div><div>The role of probiotics and prebiotics in alleviating symptoms related to metabolic diseases (METs) through the regulation of gut microbiota has garnered significant attention. Recent studies have demonstrated that stachyose (STA) selectively promotes the proliferation of beneficial bacteria, such as Bifidobacteria and Lactobacillus, which are vital for intestinal health. The enhancement of these beneficial bacteria by STA leads to improved homeostasis of the gastrointestinal microbial ecosystem and a reduction in harmful bacteria, potentially mitigating conditions like obesity and diabetes. Furthermore, STA operates through several mechanisms: enhancing intestinal barrier function, boosting short-chain fatty acid (SCFA) production, and regulating bile acid metabolism. These mechanisms are critical for maintaining a healthy gut microbiota and preventing METs. This study aims to investigate how STA influences METs through gut microbiota regulation, with an emphasis on its sources, activities, and mechanisms of action. A deeper understanding of STA's effects on gut microbiota could provide valuable insights and inspire future treatment strategies for METs.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106778"},"PeriodicalIF":3.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Lactobacillus rhamnosus GG and luxS mutant on gut barrier function of mice challenged with Escherichia coli 比较鼠李糖乳杆菌 GG 和 luxS 突变体对受到大肠杆菌挑战的小鼠肠道屏障功能的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-29 DOI: 10.1016/j.jff.2025.106766

Zhaoxi Deng , Yanfei Ma , Kangwei Hou , Jinyan Dai , Yifan Zhong , Yingying Mao , Jinzhi Zhang , Haifeng Wang

{"title":"Comparison of Lactobacillus rhamnosus GG and luxS mutant on gut barrier function of mice challenged with Escherichia coli","authors":"Zhaoxi Deng , Yanfei Ma , Kangwei Hou , Jinyan Dai , Yifan Zhong , Yingying Mao , Jinzhi Zhang , Haifeng Wang","doi":"10.1016/j.jff.2025.106766","DOIUrl":"10.1016/j.jff.2025.106766","url":null,"abstract":"<div><div>Quorum sensing (QS) is an essential pathway for bacterial communication through autoinducers (AIs). The <em>luxS</em> gene involved in QS has been proven to regulate different behavior of <em>Lactobacillus rhamnosus</em> GG (LGG), whereas it is unclear whether the AI-2/LuxS system have beneficial effects the host by regulating LGG. Our aim was to investigate whether <em>luxS</em> mutation affects the ability of LGG to maintain intestinal microbiota homeostasis, intestinal barrier integrity and inflammatory immune responses in mice infected with <em>Escherichia coli</em> (<em>E. coli</em>). This study showed that both wild-type (WT) and <em>luxS</em> mutant (ΔluxS) of LGG can alleviate changes in the microbiota caused by <em>E. coli</em> by down-regulating the relative abundance of <em>Parasturtella</em>. Supplementation with WT and ΔluxS increased the CD4<sup>+</sup>/CD8<sup>+</sup> ratio in spleen, improved goblet cell numbers and enhanced Muc 2 secretion. Moreover, WT and ΔluxS decreases proinflammatory mediator levels by inhibiting MAPK and NF-κB signal transduction.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106766"},"PeriodicalIF":3.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuning peptide self-assembly patterns in Tilapia scale gelatin hydrolysates through Cu2+ coordination: Characterization, identification and antioxidant evaluation 通过Cu2+配位调节罗非鱼鳞片明胶水解产物的肽自组装模式：表征、鉴定和抗氧化评价

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-29 DOI: 10.1016/j.jff.2025.106747

Jairo Andrés Camaño Echavarría , Raliat O. Abioye , Samanta Sarahí Reyes , Katalin Selmeczi , Laetitia Canabady-Rochelle , Chibuike C. Udenigwe

{"title":"Tuning peptide self-assembly patterns in Tilapia scale gelatin hydrolysates through Cu2+ coordination: Characterization, identification and antioxidant evaluation","authors":"Jairo Andrés Camaño Echavarría , Raliat O. Abioye , Samanta Sarahí Reyes , Katalin Selmeczi , Laetitia Canabady-Rochelle , Chibuike C. Udenigwe","doi":"10.1016/j.jff.2025.106747","DOIUrl":"10.1016/j.jff.2025.106747","url":null,"abstract":"<div><div>We investigated the self-assembly pattern of Tilapia scale gelatin hydrolysates through Cu<sup>2+</sup> coordination and their in vivo antioxidant properties by Cu<sup>2+</sup>-induced oxidative stress using the <em>Caenorhabditis elegans</em>. Two treatments (Alcalase®, Alc; and Alcalase® followed by Flavourzyme®, Alc+Flav) were used to prepare whole and ≤ 1 kDa hydrolysates. Upon Cu<sup>2+</sup> coordination, the fibrillation and surface hydrophobicity of all hydrolysates decreased, suggesting a degradation of β-sheet structures and the formation of amorphous aggregates. Rheological studies confirmed that the structural and mechanical properties of the resulting supramolecular assemblies are tunable after Cu<sup>2+</sup> coordination. Due to the Cu<sup>2+</sup>-chelating and self-assembly properties, peptides present in the Alc hydrolysate significantly reduced endogenous ROS levels through Cu<sup>2+</sup> coordination, thereby extending the lifespan of <em>C. elegans</em>. The results provide valuable insights into the influence of Cu<sup>2+</sup> coordination on the progression of peptide self-assembly and Cu<sup>2+</sup>-induced oxidation in worms and prospects for food self-assembled peptides in biomaterial and nutraceutical applications.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106747"},"PeriodicalIF":3.8,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The metabolic health effects of early-life burdock (Arctium lappa L.) root inulin intervention on gut-liver omics 早期牛蒡根菊粉干预对肠-肝组学代谢健康的影响

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-28 DOI: 10.1016/j.jff.2025.106776

Chunyan Liu , Yulong Bao , Qing Zhang, Chenguang Zhang, Guodong Wang, Taili Shao

{"title":"The metabolic health effects of early-life burdock (Arctium lappa L.) root inulin intervention on gut-liver omics","authors":"Chunyan Liu , Yulong Bao , Qing Zhang, Chenguang Zhang, Guodong Wang, Taili Shao","doi":"10.1016/j.jff.2025.106776","DOIUrl":"10.1016/j.jff.2025.106776","url":null,"abstract":"<div><div>Inulin, a common food additive, has prebiotic properties. The study, we evaluated the effect of early-life burdock (<em>Arctium lappa</em> L.) root inulin (BRI) intervention on C57BL/6 J male mice. Two groups: normal control (NC; standard diet + drinking water) and BRI group (standard diet +2 % BRI drinking water [<em>w</em>/<em>v</em>]). After 6-month experiment, BRI supplementation prevented abdominal and liver fat accumulation in mice, improving serum glucose, total cholesterol, triglycerides and low-density lipoprotein levels. Dietary BRI increased intestinal microbiota diversity and reduced the <em>Firmicutes</em>/<em>Bacteroidota</em> ratio. The relative abundances of negatively correlated with lipogenesis <em>Parabacteroides</em> and <em>Desulfovibrio</em> were increased. Non-targeted metabolomics of liver tissue indicated that BRI affected lipids and lipid-like metabolites. Liver tissue transcriptomics revealed that lipid metabolism and atherosclerosis genes, bile secretion genes were significantly different. These results demonstrate the effect of BRI on lipid metabolism, reducing the risk of diet-related chronic non-communicable diseases, particularly abdominal obesity and non-alcoholic fatty liver.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106776"},"PeriodicalIF":3.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The porcine bone collagen-derived peptides suppressed the low-grade chronic inflammation via restraining calcium-sensing receptor in RAW264.7 cells 猪骨胶原衍生肽通过抑制RAW264.7细胞钙敏感受体抑制低级别慢性炎症

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-28 DOI: 10.1016/j.jff.2025.106726

Zixu Wang , Yuejing Hao , Lujuan Xing , Wangang Zhang

{"title":"The porcine bone collagen-derived peptides suppressed the low-grade chronic inflammation via restraining calcium-sensing receptor in RAW264.7 cells","authors":"Zixu Wang , Yuejing Hao , Lujuan Xing , Wangang Zhang","doi":"10.1016/j.jff.2025.106726","DOIUrl":"10.1016/j.jff.2025.106726","url":null,"abstract":"<div><div>In the current study, the anti-inflammatory capacity of porcine bone collagen peptides (PBPs) was investigated in RAW264.7 cells. During the simulated digestion process, the PBPs showed a significant inhibiting effect on the secretion of tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in RAW264.7 cells. The PBPs (10 μg/mL) significantly decreased the Ca<sup>2+</sup> fluorescence intensity compared with the lipopolysaccharide (LPS) induced group. Furthermore, the anti-inflammatory peptide sequences were selected according to the binding property with the CaSR, among which the GPTGF (Gly-Pro-Thr-Gly-Phe) showed a significant inflammatory regulating effect and also checked to be transported in Caco-2 monolayer cells. Compared with the Cinacalcet-treated group, the GPTGF posed to suppress the CaSR and then inhibited the mRNA expressions of TNF-α, and interleukin-6 (IL-6). Generally, the PBPs were demonstrated to suppress the inflammatory response in RAW264.7 cells by inhibiting CaSR as the major pathway to exert the anti-inflammatory effect.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106726"},"PeriodicalIF":3.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological mechanisms, pharmacological and pathological activities, and quality optimization of gingerols and shogaols 姜辣素和姜辣素的生物学机制、药理和病理活性及品质优化

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-28 DOI: 10.1016/j.jff.2025.106773

Xicen Jiang

引用次数: 0

Colonic microbiome modulation and metabolic effects of Bryndza sheep cheese in pediatric acute lymphoblastic leukemia: An in vitro study Bryndza羊奶酪对儿童急性淋巴细胞白血病的结肠微生物调节和代谢作用：一项体外研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-27 DOI: 10.1016/j.jff.2025.106755

Galal Ali Esmail , Saba Miri , Ivan Hric , Walid Mottawea , Libuša Nechalová , Miroslava Šimiaková , Luana Leao , Martin Kolisek , Alexandra Kolenová , Viktor Bielik , Riadh Hammami

{"title":"Colonic microbiome modulation and metabolic effects of Bryndza sheep cheese in pediatric acute lymphoblastic leukemia: An in vitro study","authors":"Galal Ali Esmail , Saba Miri , Ivan Hric , Walid Mottawea , Libuša Nechalová , Miroslava Šimiaková , Luana Leao , Martin Kolisek , Alexandra Kolenová , Viktor Bielik , Riadh Hammami","doi":"10.1016/j.jff.2025.106755","DOIUrl":"10.1016/j.jff.2025.106755","url":null,"abstract":"<div><div>This study investigated the effects of lyophilized, unpasteurized Bryndza sheep cheese powder on gut microbiota and short-chain fatty acid (SCFA) production using an <em>in vitro</em> colonic fermentation model of pediatric acute lymphoblastic leukemia (ALL) patients. Low-dose (LD; 500 mg) and high-dose (HD; 1000 mg) treatments led to distinct microbial shifts within 48 h, affecting <em>Firmicutes</em>, <em>Bacteroidota</em>, and <em>Proteobacteria</em>. The α-diversity decreased in LD (<em>p</em> < 0.05) but remained highest in HD (<em>p</em> ≤ 0.01) after 48 h. <em>Parasutterella</em> and <em>Enterococcus</em> were enriched at 6 h, with HD promoting SCFA-producing bacteria (<em>Faecalibacterium</em>) at later stages. By 48 h, the HD increased <em>Eubacterium hallii</em>, <em>Faecalibacterium</em>, and <em>Bacteroides</em>, whereas LD enriched <em>Lachnospira</em> and <em>Veillonella</em>. Both treatments significantly increased acetate production (<em>p</em> ≤ 0.01), with network analysis linking key microbiota families to SCFA production. Bryndza cheese modulates gut microbiota dose- and time-dependently, fostering SCFA-producing taxa and potentially improving gut health in pediatric ALL patients.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106755"},"PeriodicalIF":3.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular benefits of standardized Aronia melanocarpa (Michx.) Elliot extract: Insights from a short-term pilot randomized human trial and cell culture studies 标准化黑檀对心血管的益处艾略特提取物：从短期试点随机人体试验和细胞培养研究的见解

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-27 DOI: 10.1016/j.jff.2025.106769

Patrycja Bloch , Karolina Niska , Barbara Khaidakov , Agata Michna , Krzysztof Lemke , Paulina Kowalczyk

{"title":"Cardiovascular benefits of standardized Aronia melanocarpa (Michx.) Elliot extract: Insights from a short-term pilot randomized human trial and cell culture studies","authors":"Patrycja Bloch , Karolina Niska , Barbara Khaidakov , Agata Michna , Krzysztof Lemke , Paulina Kowalczyk","doi":"10.1016/j.jff.2025.106769","DOIUrl":"10.1016/j.jff.2025.106769","url":null,"abstract":"<div><div>Cardiovascular diseases (CVDs) remain a major global health burden, emphasizing the need for effective preventive strategies. Polyphenols in <em>Aronia melanocarpa</em> (AM) have emerged as promising candidates due to their potent antioxidant and anti-inflammatory properties. This study evaluated the effectiveness of standardized AM extract supplementation in mitigating CVD risk factors through a 6-week pilot randomized human trial and <em>in vitro</em> experiments. The human trial demonstrated significant reductions in total cholesterol, LDL cholesterol, and alanine aminotransferase (ALAT) levels in the supplemented group. <em>In vitro</em> studies confirmed AM extract's anti-inflammatory effects, as indicated by reduced pro-inflammatory cytokines and adhesion molecules in human endothelial cells (HUVECs) and human peripheral blood mononuclear cells (PBMCs). Additionally, AM extract exhibited strong antioxidant activity and enhanced nitric oxide (NO) production in cells. These findings underscore the potential of AM extract to improve lipid profiles, vascular function, and liver health, supporting its role in CVD prevention and management.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106769"},"PeriodicalIF":3.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0