Journal of Functional Foods最新文献_第10页

Polysaccharide from Ziziphus jujuba fruit protects ulcerative colitis mice via IL-33/ST2 signal Axis 酸枣多糖通过IL-33/ST2信号轴保护溃疡性结肠炎小鼠

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-11 DOI: 10.1016/j.jff.2025.106839

Shiying Huang , Rui Wang , Xueying Lu , Pingli Mo , Jiazhen Wu , Zhonggui Li , Zheng-Quan Lai , Huimin Yu , Muxia Li , Jianping Chen

{"title":"Polysaccharide from Ziziphus jujuba fruit protects ulcerative colitis mice via IL-33/ST2 signal Axis","authors":"Shiying Huang , Rui Wang , Xueying Lu , Pingli Mo , Jiazhen Wu , Zhonggui Li , Zheng-Quan Lai , Huimin Yu , Muxia Li , Jianping Chen","doi":"10.1016/j.jff.2025.106839","DOIUrl":"10.1016/j.jff.2025.106839","url":null,"abstract":"<div><div>Jujube is a medicinal herb and daily food. Polysaccharides extracted from jujube possesses immune regulatory activity. In this study, we investigated whether jujube polysaccharides (JP) could ameliorate ulcerative colitis (UC), an inflammatory disease, and explore the potential mechanism of UC. We first extracted and characterized the structure JP, using dextran sulfate sodium-induced UC mice model to verify the pharmacological function. Research proved that JP treatment could ease UC mice symptoms and pathological injury. According to transcriptomics analysis, majority genes were enriched to cytokines-cytokines receptors signal pathway. Results showed that the increasing proinflammatory cytokines in UC mice colon were declined after JP intervention. Meanwhile, the receptor of interleukin-33 (IL-33), tumorigenicity 2 suppression (ST2) and downstream protein MYD88 expression in UC mice colon were corrected by JP intervention. As a result, according to immunohistochemistry detection, JP downregulated UC mice colon T cells expression (labeled by CD3+). We further employed flow cytometry to validate that JP could suppress CD4+ high expression on Jurkat cell stimulated by IL-33. In conclusion, JP could ameliorate UC mice symptoms, the mechanism of which was related to the regulation of IL-33/ST2 axis.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106839"},"PeriodicalIF":3.8,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect and mechanism of polysaccharide from Crataegus pinnatifida on nonalcoholic fatty liver disease 山楂多糖对非酒精性脂肪肝的作用及机制研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-10 DOI: 10.1016/j.jff.2025.106876

Hanju Fan , Meng Yan , Yongshuai Jing , Ziyan Li , Yaqian He , Zhiwei Li , Junna Song , Lanfang Wu

{"title":"Effect and mechanism of polysaccharide from Crataegus pinnatifida on nonalcoholic fatty liver disease","authors":"Hanju Fan , Meng Yan , Yongshuai Jing , Ziyan Li , Yaqian He , Zhiwei Li , Junna Song , Lanfang Wu","doi":"10.1016/j.jff.2025.106876","DOIUrl":"10.1016/j.jff.2025.106876","url":null,"abstract":"<div><div><em>Crataegus pinnatifida</em> is the dried fruit of <em>Crataegus pinnatifida</em>. <em>Crataegus pinnatifida</em> polysaccharides (CPPs) eluted with water as the mobile phase (CPPs-H-1) is one of the important active components. CPPs-H-1 has anti-oxidation and blood lipid regulation activities in vitro. Therefore, we investigated the effects of CPPs-H-1 on nonalcoholic fatty liver disease (NAFLD) in C57/BL6J mice. As a result, CPPs-H-1 inhibited the rapid growth of body weight and alleviated the liver injury caused by high-fat diets, significantly reducing the liver index and blood lipid levels in the model group, inhibiting the production of inflammation and cytokines, and inhibiting oxidative stress. CPPs-H-1 also enhanced intestinal barrier function. At the phylum level, CPPs-H-1 reduced the ratio of <em>Firmicutes</em> to <em>Bacteroides</em> (F/B) and regulated the content of short-chain fatty acids (SCFAs). The CPPs-H-1 may regulate intestinal flora composition, and improve intestinal barrier function, ultimately delaying the progression of NAFLD in mice. Also, CPPs-H-1 improved NAFLD progression by enhancing the Amp-activated protein kinase (AMPK)/peroxisome proliferator-activated receptor α (PPARα) signaling pathway to enhance fatty acid oxidation. All these results confirm that CPPs-H-1 plays a multi-pathway and multi-target role in the improvement of NAFLD.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106876"},"PeriodicalIF":3.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediococcus pentosaceus decreases α-synuclein accumulation and alleviates parkinsonism in Caenorhabditis elegans and Oryzias latipes 戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeococcus戊sacpeo球菌

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-09 DOI: 10.1016/j.jff.2025.106869

Tomomi Komura , Masayuki Yoshida , Rio Kurihara , Masato Kinoshita , Masaru Yoshida , Yoshikazu Nishikawa

{"title":"Pediococcus pentosaceus decreases α-synuclein accumulation and alleviates parkinsonism in Caenorhabditis elegans and Oryzias latipes","authors":"Tomomi Komura , Masayuki Yoshida , Rio Kurihara , Masato Kinoshita , Masaru Yoshida , Yoshikazu Nishikawa","doi":"10.1016/j.jff.2025.106869","DOIUrl":"10.1016/j.jff.2025.106869","url":null,"abstract":"<div><div>In Parkinson's disease (PD), α-synuclein (α-syn) accumulation drives neuropathological progression, establishing it as a potential therapeutic target. Lactic acid bacteria (LAB) provide various health benefits to the host and are expected to offer protective effects on neurological functions through the brain–gut connection, as indicated by animal studies. However, the protective effects of LAB against α-syn are not well understood. We investigated whether LAB feeding could reduce α-syn accumulation and improve mobility in transgenic <em>Caenorhabditis elegans</em>, an invertebrate model organism that expresses human α-syn. Among the nine screened strains, <em>Pediococcus pentosaceus</em> MCRI-640 suppressed α-syn accumulation and the decrease in bending counts, a locomotion index in nematodes. Additionally, feeding <em>P. pentosaceus</em> MCRI-640 to <em>Oryzias latipes</em> (medaka), a vertebrate model organism, alleviated PD-like behavioral defects induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). <em>P. pentosaseus</em> acts as a probiotic against PD, and PD model worms and medaka can be used to screen effective LAB for prevention.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106869"},"PeriodicalIF":3.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Study on the active ingredients and molecular mechanisms of Polygonatum sibiricum beverage in the intervention of type 2 diabetes mellitus based on UPLC-MS, network pharmacology and experimental validation” [Journal of Functional Foods Vol. 127 Article 106762] “基于UPLC-MS、网络药理学和实验验证的黄精饮料干预2型糖尿病的有效成分和分子机制研究”[Journal of Functional Foods Vol. 127 Article 106762]的勘误表

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-09 DOI: 10.1016/j.jff.2025.106806

Meixian Ruan , Qianlong Ai , Guochao Cao , Fengxiao Ren , Zhouyao Zhang , Dekai Wang , Qiaojun Jia

引用次数: 0

Role of dietary fiber and short-chain fatty acids in preventing neurodegenerative diseases through the gut-brain axis 膳食纤维和短链脂肪酸通过肠-脑轴预防神经退行性疾病的作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-09 DOI: 10.1016/j.jff.2025.106870

Uyory Choe

{"title":"Role of dietary fiber and short-chain fatty acids in preventing neurodegenerative diseases through the gut-brain axis","authors":"Uyory Choe","doi":"10.1016/j.jff.2025.106870","DOIUrl":"10.1016/j.jff.2025.106870","url":null,"abstract":"<div><div>As global life expectancy rises, maintaining physical and mental health is increasingly vital, particularly for aging populations. Neurodegenerative diseases like Alzheimer's, Parkinson's, amyotrophic lateral sclerosis, and multiple sclerosis significantly affect quality of life and pose public health challenges. Emerging evidence highlights dietary fiber and its metabolites, short-chain fatty acids (SCFAs), as crucial in promoting gut health and preventing these diseases.</div><div>This review explores current mechanistic insights into how SCFAs influence gut-brain communication and provides an integrative perspective by comparing fiber-based and non-fiber-based dietary interventions, such as Mediterranean-DASH intervention for neurodegenerative delay (MIND) and ketogenic diets.</div><div>It also highlights emerging synergistic approaches that combine dietary fiber with functional foods like polyphenols, offering novel opportunities for dietary modulation of neurodegenerative disease risk. These findings support the development of fiber-focused dietary interventions to promote the production of SCFAs and potentially delay neurodegenerative disease progression in elderly populations.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106870"},"PeriodicalIF":3.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of polyphenols and polyphenol-rich extracts against human papillomavirus infections and associated cancers 多酚和富含多酚的提取物对抗人类乳头瘤病毒感染和相关癌症的潜力

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-09 DOI: 10.1016/j.jff.2025.106873

Atefeh Arab , Fatemeh Amini , Aida Iraji , Mohammad Hashem Hashempur

{"title":"The potential of polyphenols and polyphenol-rich extracts against human papillomavirus infections and associated cancers","authors":"Atefeh Arab , Fatemeh Amini , Aida Iraji , Mohammad Hashem Hashempur","doi":"10.1016/j.jff.2025.106873","DOIUrl":"10.1016/j.jff.2025.106873","url":null,"abstract":"<div><div>Human papillomavirus (HPV) infection is a prevalent sexually transmitted infection worldwide, that can affect the skin, genital area, and throat. HPV can lead to various cancers, including cervical and anogenital cancers. Although HPV vaccination is a preventive measure, its availability remains limited, particularly in low- and middle-income countries, leading to increased demand for alternative preventive and therapeutic options. Recent research has highlighted the potential of dietary polyphenols to reduce HPV infections and related malignancies. Polyphenolic-rich foods may inhibit cancer cell proliferation through mechanisms such as stimulating immune responses, reducing DNA synthesis, inducing apoptosis, and inhibiting angiogenesis. This study reviews the therapeutic properties of polyphenols and their mechanisms in preventing HPV infection and related cancers. Future studies should focus on the clinical application of polyphenols in diverse populations and their efficacy as complementary treatments for HPV-related malignancies.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106873"},"PeriodicalIF":3.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propolis-derived vesicle-like nanoparticles: A study on their anti-inflammatory mechanisms and potential therapeutic applications 蜂胶衍生的囊泡状纳米颗粒：其抗炎机制和潜在治疗应用的研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-09 DOI: 10.1016/j.jff.2025.106852

Minh Ha Le , Hyo-Jun Lee , Jin-Ah Koh , Jin-Woo Min , Mi Jung Kim , Hee-Cheol Kang , Yeon-Ju Kim

{"title":"Propolis-derived vesicle-like nanoparticles: A study on their anti-inflammatory mechanisms and potential therapeutic applications","authors":"Minh Ha Le , Hyo-Jun Lee , Jin-Ah Koh , Jin-Woo Min , Mi Jung Kim , Hee-Cheol Kang , Yeon-Ju Kim","doi":"10.1016/j.jff.2025.106852","DOIUrl":"10.1016/j.jff.2025.106852","url":null,"abstract":"<div><div>The efficacy of food-derived vesicles in regulating inflammation-related diseases has garnered considerable attention. Propolis is particularly notable for its diverse biological activities, including anti-diabetic, anti-obesity and anticancer effects. In this study, we introduced propolis-derived vesicle-like nanoparticles (PVNs) as a new bioactive compound of propolis that exert anti-inflammatory effects in lipopolysaccharide-stimulated RAW264.7 macrophages. Characterization of PVNs revealed a bilayer membrane structure with an average vesicle size of 110 ± 38.3 nm. In bioactivity assays, PVNs treatment significantly reduced cytokine secretion (IL-6, IL-10, IL-12, TNF-α, and IL-1β), and inflammatory mediators (NO and PGE<sub>2).</sub> These effects were accompanied by down-regulation of <em>iNOS</em> and <em>COX-2</em>, mediated by the inhibition of the TLR4/NF-κB signaling pathway. Additionally, PVNs treatment substantially inhibited LPS-induced oxidative stress in RAW264.7 cells. These findings highlight PVNs as potent anti-inflammatory agents, offering potential applications in treating inflammation-related diseases and as nanoscale drug delivery systems.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106852"},"PeriodicalIF":3.8,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylated urolithin a attenuates lipopolysaccharide-induced memory impairment and behavioral disorders by inhibiting mitochondrial inflammation through the Drp1/HK1/NLRP3 pathway 甲基化尿素a通过Drp1/HK1/NLRP3途径抑制线粒体炎症，减轻脂多糖诱导的记忆障碍和行为障碍

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-08 DOI: 10.1016/j.jff.2025.106851

Peng Chen , Wenhao Xiao , Fanzhao Zou , Jiexin Lei , Fuchao Chen , Ruhong Zhang

{"title":"Methylated urolithin a attenuates lipopolysaccharide-induced memory impairment and behavioral disorders by inhibiting mitochondrial inflammation through the Drp1/HK1/NLRP3 pathway","authors":"Peng Chen , Wenhao Xiao , Fanzhao Zou , Jiexin Lei , Fuchao Chen , Ruhong Zhang","doi":"10.1016/j.jff.2025.106851","DOIUrl":"10.1016/j.jff.2025.106851","url":null,"abstract":"<div><div>This study explored the effects of methylated urolithin A (mUro A), on lipopolysaccharide (LPS)-induced cognitive impairment and anxiety- and depression-like behaviors, and their molecular mechanism. mUro A significantly mitigated cognitive dysfunction, anxiety- and depression-like behaviors. Furthermore, mUro A improved activities of antioxidative enzymes, regulated the release of inflammatory factors, inhibited the LPS-induced generation of Aβ<sub>1</sub><sub>–</sub><sub>42</sub> and restored the cholinergic system balance in the AD mouse brain. Additionally, mUro A markedly attenuated microglial activation by inhibiting the Drp1/HK1/NLRP3 pathway, thereby suppressing mitochondrial inflammation. This was evidenced by the downregulation of p-Drp1 (s616), VDACs, NLRP3, ASC, cleaved caspase 1, IL-18, and IL-1β, alongside the upregulation of HK1 expression. In conclusion, mUro A mitigates AD-associated cognitive deficits by inhibiting the Drp1/HK1/NLRP3 pathway and suppressing mitochondrial inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106851"},"PeriodicalIF":3.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive compounds in colored Rice: Exploring natural agents for Cancer prevention in vitro and rodent model studies 有色米中的生物活性化合物：探索用于癌症预防的天然药物的体外和啮齿动物模型研究

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-08 DOI: 10.1016/j.jff.2025.106875

Zhiang Chen , Atiruj Theppawong , Papungkorn Sangsawad , Jiayue Fang , Hui Ye , Shanggui Deng , Min Yang , Jingrong Gao , Supaluck Kraithong

{"title":"Bioactive compounds in colored Rice: Exploring natural agents for Cancer prevention in vitro and rodent model studies","authors":"Zhiang Chen , Atiruj Theppawong , Papungkorn Sangsawad , Jiayue Fang , Hui Ye , Shanggui Deng , Min Yang , Jingrong Gao , Supaluck Kraithong","doi":"10.1016/j.jff.2025.106875","DOIUrl":"10.1016/j.jff.2025.106875","url":null,"abstract":"<div><div>Pigmented rice varieties, including red, black, and purple rice, are rich in bioactive compounds like anthocyanins, flavonoids, and phenolic acids, which exhibit antioxidant, anti-inflammatory, and anticancer properties. This review explores their phenolic composition, mechanisms in cancer prevention, and stability during food processing. Anthocyanins in black rice inhibit tumor growth and metastasis by targeting pathways such as RAF/MEK/ERK and downregulating matrix metalloproteinases (MMPs). Proanthocyanidins in red rice modulate NF-κB signaling, reducing inflammation and cancer cell invasion. These compounds also induce apoptosis, arrest the cell cycle, and inhibit angiogenesis, offering multifaceted cancer prevention strategies. Additionally, pigmented rice bioactives mitigate oxidative stress and inflammation, key contributors to carcinogenesis. While their potential is promising, further research is needed to validate clinical efficacy and optimize processing stability. Pigmented rice represents a valuable dietary intervention for reducing cancer risk and promoting overall health.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106875"},"PeriodicalIF":3.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143917919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phellinus igniarius alcohol extract restores the immune homeostasis in cyclophosphamide induced immunocompromised mice 黄连醇提取物可恢复环磷酰胺诱导的免疫功能低下小鼠的免疫稳态

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-05-08 DOI: 10.1016/j.jff.2025.106861

Anni Xie , Fang He , Li Wang , Wenjing Shi , Panling Xu , Ting Wang , Ping Li

{"title":"Phellinus igniarius alcohol extract restores the immune homeostasis in cyclophosphamide induced immunocompromised mice","authors":"Anni Xie , Fang He , Li Wang , Wenjing Shi , Panling Xu , Ting Wang , Ping Li","doi":"10.1016/j.jff.2025.106861","DOIUrl":"10.1016/j.jff.2025.106861","url":null,"abstract":"<div><div>It is common for cancer patients to experience immune dysfunction after chemotherapy, which increases their risk of infection and tumor recurrence. Restoring immune homeostasis is therefore of great importance. Phellinus igniarius's role in restoring immune homeostasis is unclear. This study conducts mass spectrometry analysis on Phellinus igniarius alcohol extract to identify its main components, and then conducts animal experiments to clarify the effects of Phellinus igniarius alcohol extract on the immunocompromised mice induced by cyclophosphamide, observing the changes on mice state, immune organs indices, CD4+/CD8+ T cells ratio, immune cells functions, and cytokines secretion. Phellinus igniarius alcohol extract (P-AE) exhibited a dose-dependent trend in restoring immune homeostasis in cyclophosphamide-induced immunocompromised mice. Compared to the cyclophosphamide group, the P-AE-1000 group mice showed significant differences in vitality, immune organs indices, CD4+/CD8+ T cells ratio, immune cells functions, and cytokines secretion. This study found that Phellinus igniarius alcohol extract could increase the ratio of CD4+/CD8+ T cells, improve the level of cytokines secretion, and rebuild the immune homeosta of immunocompromised mice.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"129 ","pages":"Article 106861"},"PeriodicalIF":3.8,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0