Journal of Functional Foods最新文献_第10页

Phytochemical profile of Pereskia aculeata Miller and its bioactive constituents for treating rheumatoid arthritis' s inflammation via inhibiting COX-2 target 通过抑制COX-2靶点治疗类风湿关节炎的植物化学特征及其生物活性成分

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-27 DOI: 10.1016/j.jff.2025.106771

Shuo Tian , Ao Duan , Ping Li , Zishan Zhou , Qiqing Huang , Yifei Chen , Quanhong Zhu , Yongyan Zhu

{"title":"Phytochemical profile of Pereskia aculeata Miller and its bioactive constituents for treating rheumatoid arthritis' s inflammation via inhibiting COX-2 target","authors":"Shuo Tian , Ao Duan , Ping Li , Zishan Zhou , Qiqing Huang , Yifei Chen , Quanhong Zhu , Yongyan Zhu","doi":"10.1016/j.jff.2025.106771","DOIUrl":"10.1016/j.jff.2025.106771","url":null,"abstract":"<div><div><em>Pereskia aculeata</em> Miller (OPN), an edible plant, has the potential to treat the inflammation of rheumatoid arthritis (RA). This article aimed to characterize its phytochemical profile and to explore the key target and bioactive compounds against RA. Using UPLC-MS combined with reference substances, 75 components were characterized. Network pharmacology suggested that COX-2 may be the key target for OPN in suppressing RA-related inflammation. Subsequently, it was validated OPN exerts inhibitory effect on inflammation via reducing pro-inflammatory factor IL-6 level and suppressing the enzyme catalytic activity and mRNA expression of COX-2. Moreover, 11 potential bioactive compounds were found, in which cynaroside showed potent effect on reducing IL-6 level in lipopolysaccharide-induced RAW264.7 cells by acting on COX-2. Hence, we considered cynaroside is a main bioactive ingredient of OPN in the treatment of RA's inflammation via COX-2 target, which is possibly related to a strong binding to COX-2 protein and occupying some catalytic residues, thereby blocking the production of prostaglandins and inflammatory process.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106771"},"PeriodicalIF":3.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking betaine's potential: A novel therapeutic avenue for diabetes-induced erectile dysfunction 释放甜菜碱的潜力：一种治疗糖尿病性勃起功能障碍的新途径

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-27 DOI: 10.1016/j.jff.2025.106777

Zian Wang , Guanbo Wang , Danfeng Zhao , Qiang Fu

引用次数: 0

Cydonia oblonga Mill. fruit extract attenuates depressive-like behaviors in a mouse model of breast tumor via regulating oxidative stress, inflammation, and gut microbiota 长尾草。水果提取物通过调节氧化应激、炎症和肠道微生物群来减轻乳腺肿瘤小鼠模型中的抑郁样行为

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106775

Jia Wei , Gusonghan Maitiniyazi , Yin-Yin Gu , Jing-Wei Peng , Ye Sun , Shu-Fang Xia

{"title":"Cydonia oblonga Mill. fruit extract attenuates depressive-like behaviors in a mouse model of breast tumor via regulating oxidative stress, inflammation, and gut microbiota","authors":"Jia Wei , Gusonghan Maitiniyazi , Yin-Yin Gu , Jing-Wei Peng , Ye Sun , Shu-Fang Xia","doi":"10.1016/j.jff.2025.106775","DOIUrl":"10.1016/j.jff.2025.106775","url":null,"abstract":"<div><div><em>Cydonia oblonga</em> Mill. is a flavonoid-rich fruit and has potential applications in functional or nutritional foods. Herein, we examined the effects of hydroethanolic extract of <em>Cydonia oblonga</em> Mill. fruit (HECO, 600 mg/kg) on depressive-like behaviors in a mouse model of breast tumor. Flavonoids in HECO were determined by Ultra-Performance Liquid Chromatography-Mass Spectrometry. Depressive-like behaviors and hippocampal oxidative stress markers and inflammatory cytokines were measured. Colonic contents were collected for 16S rRNA sequencing. HECO was enriched with rutin, L-epicatechin, catechin and other flavonoids and significantly increased the time spent in the center of the open-field test and sucrose water consumption, and decreased immobility time in the tail suspension test without significant effect on tumor growth. HECO significantly increased hippocampal 5-hydroxytryptamine, brain-derived neurotrophic factor levels, glutathione peroxidase and superoxide dismutase activities, decreased hippocampal interleukin-6, interleukine-1β, tumor necrosis factor-α and malondialdehyde levels. In addition, HECO increased diversity of gut microbiota and improved intestinal barrier integrity. This study suggests that HECO is a potential candidate for breast cancer-related depression by regulating gut microbiota and inhibiting hippocampal oxidative stress and inflammation.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106775"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats 核桃粉蛋白水解物可减轻l - name诱导的高血压大鼠HepG2和3t3 - l1细胞的脂质积累和氧化应激，并协同增强卡托普利的降压作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106772

Pakaporn Sa-nguanpong , Paweena Wetprasit , Anjaree Inchan , Chartchai Chaichana , Worasak Kaewkong , Natthawut Charoenphon , Kannika Adthapanyawanich , Krit Tantanarat , Worasit Tochampa , Khanitta Ruttarattanamongkol , Tippaporn Bualeong

{"title":"Sacha inchi meal protein hydrolysate mitigates lipid accumulation and oxidative stress in HepG2 and 3 T3-L1 cells and synergistically enhances captopril's antihypertensive effects in L-NAME-induced hypertensive rats","authors":"Pakaporn Sa-nguanpong , Paweena Wetprasit , Anjaree Inchan , Chartchai Chaichana , Worasak Kaewkong , Natthawut Charoenphon , Kannika Adthapanyawanich , Krit Tantanarat , Worasit Tochampa , Khanitta Ruttarattanamongkol , Tippaporn Bualeong","doi":"10.1016/j.jff.2025.106772","DOIUrl":"10.1016/j.jff.2025.106772","url":null,"abstract":"<div><div>This study evaluates the antihypertensive effects of Sacha Inchi meal protein hydrolysate (SIPH) in L-NAME-induced hypertensive rats. Male Sprague Dawley rats treated with L-NAME (40 mg/kg) received SIPH (100, 300, or 500 mg/kg), captopril (5 mg/kg), or a combination of captopril (2.5 mg/kg) and SIPH (500 mg/kg) for 5 weeks. Blood pressure was monitored weekly and verified via carotid artery cannulation. SIPH at 500 mg/kg, incombination with captopril, significantly reduced blood pressure, upregulated eNOS expression, alleviated renal and liver injury, enhanced sperm viability, and downregulated VCAM-1 expression. In HepG2 and 3 T3-L1 cells, SIPH mitigated oxidative stress, hepatic steatosis, and lipid accumulation. Together, these in vitro and in vivo findings suggest that SIPH could serve as a promising nutraceutical candidate for antihypertensive functional foods.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106772"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EPA but not DHA improve systemic IR through activating muscle IL-6/AMPK pathway in high-fat diet-fed mice EPA而非DHA通过激活肌肉IL-6/AMPK通路改善高脂饮食小鼠的全身IR

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106749

Lianzhi Mao, Qunying Xie, Qiting Cheng, Wei Tang, Limei Mao

引用次数: 0

Exploring the active components of hypoglycemic effect in different polar fractions of Inonotus obliquus based on spectrum-effect relationship 基于谱效关系探讨斜叶莲子不同极性组分降血糖作用的活性成分

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106767

Jianping Wu , Lidong Xie , Zhongyuan Qu , Hui Song , Xiangming Sun , Yang Hu , Wenlan Li

{"title":"Exploring the active components of hypoglycemic effect in different polar fractions of Inonotus obliquus based on spectrum-effect relationship","authors":"Jianping Wu , Lidong Xie , Zhongyuan Qu , Hui Song , Xiangming Sun , Yang Hu , Wenlan Li","doi":"10.1016/j.jff.2025.106767","DOIUrl":"10.1016/j.jff.2025.106767","url":null,"abstract":"<div><div><em>Inonotus obliquus</em> (IO) is a kind of precious medicinal and edible fungi parasitized on birch trees in the cold zone, is widely recognized for its hypoglycemic properties. However, the material basis of its efficacy is unclear. This study investigated the hypoglycemic potential of polar fractions from IO and identified key active components. Using UPLC-Q-TOF/MS, we analyzed chemical compositions and evaluated the effects in a T2DM mouse model. IO-treated groups reduced FBG, OGTT-AUC, GSP, INS, HOMA-IR, TC, TG, LDL-c, ALT, and AST levels, and increased HDL-c. The IO-J fraction demonstrated a relatively prominent effect and liver protection in T2DM mice. Spectrum-effect relationship analysis revealed seven compounds correlated with hypoglycemia: Osmundacetone, Inonotusol A, Inonotusol C, Inonotusol F, Protocatechuic acid, Inonotusane F, and Inonotusone A. This research establishes the spectrum-effect relationship of IO fractions and provides a theoretical foundation for exploring the potential of IO as a hypoglycemic medicinal and edible fungi.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106767"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxytyrosol, tyrosol and their phase II metabolites as inhibitors of endothelial cell inflammation induced by high glucose levels 羟基酪醇、酪醇及其II期代谢物对高糖诱导的内皮细胞炎症的抑制作用

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106754

Sonia Zodio , Gabriele Serreli , Anna Boronat , Rafael De la Torre , Maria Paola Melis , Monica Deiana

{"title":"Hydroxytyrosol, tyrosol and their phase II metabolites as inhibitors of endothelial cell inflammation induced by high glucose levels","authors":"Sonia Zodio , Gabriele Serreli , Anna Boronat , Rafael De la Torre , Maria Paola Melis , Monica Deiana","doi":"10.1016/j.jff.2025.106754","DOIUrl":"10.1016/j.jff.2025.106754","url":null,"abstract":"<div><div>The aim of this investigation was to evaluate the protective effect of the main extra-virgin olive oil (EVOO) phenolic compounds, HT and Tyr, and their phase II metabolites, against the inflammatory response in HUVEC monolayers under hyperglycemic conditions. The alteration of endothelial barrier in HUVEC, treated with high glucose (HG, 30 mM) alone or together with EVOO phenols (1 μM), was evaluated through FITC-Dextran cell permeability test and the determination of TJ proteins occludin, zonulin and JAM-A level, in relation to redox-sensitive MAPK modulation, NLRP3 protein level and cytokines release. Obtained data showed that HG-induced increase of permeability through the alteration of TJ proteins, following the activation of upstream pathways involved in the inflammatory process such as p38, ERK1/2 and NLRP3, was reverted by pre-treatment with EVOO phenols and their metabolites, strengthening the hypothesis that these dietary compounds may exert a significant role in the maintenance of endothelial barrier integrity.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106754"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A blackcurrant powder supplement enriched with L-theanine and pine bark extract improves sleep quality in healthy older adults: Results from placebo controlled crossover study 富含l -茶氨酸和松树皮提取物的黑加仑粉补充剂可改善健康老年人的睡眠质量：来自安慰剂对照交叉研究的结果

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106768

Dominic Lomiwes , Alexander P. Kanon , Edward G. Walker , Nayer Ngametua , Janine M. Cooney , Dwayne A. Jensen , Duncan Hedderley , Kim Lo

{"title":"A blackcurrant powder supplement enriched with L-theanine and pine bark extract improves sleep quality in healthy older adults: Results from placebo controlled crossover study","authors":"Dominic Lomiwes , Alexander P. Kanon , Edward G. Walker , Nayer Ngametua , Janine M. Cooney , Dwayne A. Jensen , Duncan Hedderley , Kim Lo","doi":"10.1016/j.jff.2025.106768","DOIUrl":"10.1016/j.jff.2025.106768","url":null,"abstract":"<div><div>The potential benefits of berryfruit phytonutrients on brain health in older adults remain underexplored. This randomised, placebo-controlled crossover investigated the effects of consuming Ārepa®, a powdered blackcurrant (BC) formula (7.8 mg anthocyanins/kg bodyweight of whole freeze-dried BC, 200 mg L-theanine and 100 mg pine bark extract), daily for 4 weeks on sleep quality and psychological wellbeing of healthy older adults (62 ± 6 years). Significant treatment × time interactions were observed for habitual sleep efficiency (<em>p</em> = 0.001; q = 0.015), with participants self-reporting improvements in sleep and general wellbeing. Bioavailability of BC anthocyanins, sarmentosin, and L-theanine was measurable after 4 weeks supplementation. No significant effects were found for psychological wellbeing or mood following 4 weeks of Ārepa® supplementation. These findings suggest the potential benefits of this BC formula to improve sleep quality in older adults.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106768"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143715180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated lipid metabolomics and network pharmacology to investigate the potential mechanism of Coix seed in alleviating ulcerative colitis 结合脂质代谢组学和网络药理学研究薏苡仁缓解溃疡性结肠炎的潜在机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-26 DOI: 10.1016/j.jff.2025.106744

Zixuan Chen , Miaomiao Tong , Jiating Sun , Qinglin Wu , Zhuoran Li , Tianyi Lv , Xiaoxi Yin , Muqing Zhang , Li Li

{"title":"Integrated lipid metabolomics and network pharmacology to investigate the potential mechanism of Coix seed in alleviating ulcerative colitis","authors":"Zixuan Chen , Miaomiao Tong , Jiating Sun , Qinglin Wu , Zhuoran Li , Tianyi Lv , Xiaoxi Yin , Muqing Zhang , Li Li","doi":"10.1016/j.jff.2025.106744","DOIUrl":"10.1016/j.jff.2025.106744","url":null,"abstract":"<div><div>Coix seed (CS), an agricultural crop often eaten as a staple food, has been used as a functional food treating ulcerative colitis (UC) recently. However, the underlying mechanism of CS on treating UC remains unclear. This study innovatively explored the preventive effects of CS on dextran sulfate sodium (DSS)-induced colitis in mice and its underlying mechanisms using lipid metabolomics and network pharmacology analysis. The results demonstrated that CS significantly reduced body weight loss, DAI scores, colonic damage and pro-inflammatory cytokines levels, such as TNF-α and IL-6, in UC mice. Additionally, CS reversed the DSS-induced downregulation of tight junction proteins, including ZO-1 and Occludin. Lipidomics results indicated a significant difference in lipid status between the normal and UC mice, which was reduced following CS treatment. Notably, levels of phosphatidylethanolamine (PE) and sphingomyelin (SM) were the most significantly altered lipids in UC mice after CS treatment. Furthermore, network pharmacology analysis indicated SRC, PPARG, PTGS2, MAPK1, MAPK3 and ESR1 as key targets for CS in alleviating UC inflammation. The enrichment analysis revealed that CS targeted functional modules associated with MAPK signaling and lipid metabolism. Further experimental validation, molecular docking and molecular dynamics simulation demonstrated that CS exerts significant protective effects through the Src/JNK MAPK and Nrf2/PPARγ signaling pathways. Overall, this study elucidated the potential of CS as a treatment for UC by regulating the lipid metabolism, which may be related to the Src/JNK MAPK and Nrf2/PPARγ signaling pathways. This strategy provides an important support for the utilization and development of CS as a functional food in human wellness, especially in ameliorating UC.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106744"},"PeriodicalIF":3.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pittosporum glabratum leaf (Shanzhi tea) essential oil: Chemical composition, anticancer activities and potential mechanisms in vitro and in vivo 山之茶光秃Pittosporum glabratum leaf （Shanzhi tea）精油：化学成分、抗癌活性及体内外潜在机制

IF 3.8 2区农林科学

Journal of Functional Foods Pub Date : 2025-03-25 DOI: 10.1016/j.jff.2025.106756

Lanlan Yang , Nian Yang , Yuanquan Ran , Huan Zhao , Qiong Hu , Yi Hong , Minyi Tian

{"title":"Pittosporum glabratum leaf (Shanzhi tea) essential oil: Chemical composition, anticancer activities and potential mechanisms in vitro and in vivo","authors":"Lanlan Yang , Nian Yang , Yuanquan Ran , Huan Zhao , Qiong Hu , Yi Hong , Minyi Tian","doi":"10.1016/j.jff.2025.106756","DOIUrl":"10.1016/j.jff.2025.106756","url":null,"abstract":"<div><div>Herein, the chemical constituents of <em>Pittosporum glabratum</em> leaf essential oil (EO) were analyzed, and its anticancer efficacy was explored <em>in vitro</em> and <em>in vivo</em>. Its primary phytochemicals were <em>α</em>-caryophyllene, (<em>E</em>)-<em>β</em>-farnesene, and germacrene D. It displayed significant cytotoxicity against cancerous A549 cells and lower cytotoxicity against noncancerous MRC-5 cells. It induced cell cycle arrest in the G1 phase by downregulating CDK2-cyclin E1/2 and CDK4-cyclin D3 complexes and upregulating p21, thereby inhibiting A549 cell proliferation. It triggered A549 cell apoptosis <em>via</em> the mitochondrial pathway, resulting in the ratio increase of Bax/Bcl-2, ΔΨm decrease, Cyt c release, caspase-9 and caspase-3 activation, and PARP cleavage. It blocked migration ability by decreasing MMP-2, MMP-9, and N-cadherin levels. Additionally, it effectively suppressed tumor growth by inducing apoptosis of transplanted tumor cells in nude mice. Hence, <em>P. glabratum</em> leaf EO has remarkable anticancer properties and has great potential as an anticancer drug in the pharmaceutical field.</div></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"127 ","pages":"Article 106756"},"PeriodicalIF":3.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143683105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0