Journal of Functional Foods最新文献

{"title":"Lactobacillus plantarum fermented Laminaria japonica alleviates UVB-induced epidermal photoinflammation via the Keap-1/Nrf2 pathway","authors":"Zixin Song ,&nbsp;Qianru Sun ,&nbsp;Yuhua Xu ,&nbsp;Yuncai Tian ,&nbsp;Jiaxuan Fang ,&nbsp;Ziwen Wang ,&nbsp;Jiman Geng ,&nbsp;Dongdong Wang ,&nbsp;Changtao Wang ,&nbsp;Meng Li","doi":"10.1016/j.jff.2023.105693","DOIUrl":"10.1016/j.jff.2023.105693","url":null,"abstract":"<div><p>UVB-induced human immortal keratinocyte (HaCaT) cell damage model was established to investigate the mitigating effect of <em>Laminaria japonica Lactobacillus plantarum</em> subsp. <em>plantarum</em> fermentation broth (LJf) on epidermal photoinflammation and barrier function impairment. Compared to unfermented <em>Laminaria japonica</em> (LJ), LJf contains higher levels of potent substances, as well as stronger <em>in vitro</em> antioxidant activity. LJf is able to scavenge excessive reactive oxygen species (ROS) and increase intracellular antioxidant enzyme content and synthesis levels. We also find that LJf is superior to LJ in inhibiting the release of ILs, TNF-α and MMP-9. LJf also increased the synthesis level of barrier function proteins and decreased the secretion level of Kallikrein-7 (KLK-7), effectively alleviating the level of inflammation, abnormal cell shedding, and impaired barrier function in the epidermis. LJf can inhibit the transcription levels of downstream regulators and inflammatory factors by activating the Nrf2 signaling pathway. Safety experiments reveal that LJf is non-irritating.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105693"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464623002931/pdfft?md5=8b0fa27b73cf2cd2ccbb030d9d02bb5b&pid=1-s2.0-S1756464623002931-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42214965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Albiflorin attenuates sepsis-induced acute lung injury (ALI) via the TLR-4/NF-κB pathway","authors":"Qiongying Wei ,&nbsp;Jinquan Lin ,&nbsp;Yiming Li","doi":"10.1016/j.jff.2023.105633","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105633","url":null,"abstract":"<div><p><strong>Objective:</strong> Approximately 40% of acute lung injury (ALI) cases are caused by sepsis. Albiflorin (AF), a traditional Chinese medicine, has shown exceptional therapeutic effects against pain and inflammation in various immune-related disorders. This study aimed to evaluate the protective effect of AF against sepsis-induced ALI in cecal ligation and puncture (CLP) mouse model, and investigate the associated mechanisms. <strong>Materials and methods:</strong> To demonstrate the protective effects of AF, lipopolysaccharide (LPS)-stimulated RAW264.7 cell line and CLP-induced sepsis were used as the <em>in vitro</em> and <em>in vivo</em> models, respectively. Cell Counting Kit (CCK)-8 assay was used to determine the cell viability of AF-treated RAW264.7 cells upon LPS challenge. The expression levels of pro-inflammatory cytokines and oxidative stress markers were evaluated by enzyme-linked immunosorbent assay (ELISA), Western blot analysis and quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), including toll-like receptor (TLR)-4, cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phosphorylated nuclear factor-kappa B (p-NF-κB)/p65, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. <strong>Results:</strong> AF administration alleviated the inflammation and oxidative stress in the pulmonary tissues of mice with CLP-induced sepsis, as well as in LPS-stimulated RAW264.7 cells. The protective effect of AF could be attributed to the attenuation of TLR-4/NF-κB/p65 activation. AF treatment reduced TLR-4 expression and dampened NF-κB signaling. In LPS-stimulated RAW264.7 cells, TLR-4 overexpression abrogated the protective effects of AF. In the mouse mode, the protective effect of AF against sepsis-induced ALI was comparable to the treatment effect of dexamethasone (DEX). <strong>Conclusion:</strong> These findings suggest that AF could serve as a protective agent against sepsis-induced lung injury by inhibiting the TLR-4/NF-κB pathway.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105633"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1757689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burdock fructooligosaccharide ameliorates the hypercholesterolemia and vascular inflammation in mice by regulating cholesterol homeostasis and anti-inflammatory properties","authors":"Ying Meng ,&nbsp;Qunfei Ma ,&nbsp;Xuan Xu ,&nbsp;Liting Feng ,&nbsp;Qiang Chen ,&nbsp;Yiru Chen ,&nbsp;Zhang Li ,&nbsp;Chunyan Liu ,&nbsp;Kaoshan Chen","doi":"10.1016/j.jff.2023.105678","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105678","url":null,"abstract":"<div><p>Burdock fructooligosaccharide (BFO) is a type of linear inulin extracted from burdock root. In this study, we studied the effect of BFO in hypercholesterolemic mice model and found that BFO could decrease the total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (ox-LDL). BFO also reduce the hepatocyte damage, improve the antioxidant enzymes activity and regulate genes related to the cholesterol homeostasis in liver. Besides, we found that BFO protected the blood vessels by significantly balancing inflammatory cytokines and alleviating the up-regulation of TLR4/MyD88/NF-κB pathway in aorta. Furthermore, we established a foam cells model induced by ox-LDL <em>in vitro</em> and found that 500 and 1000 μg/mL BFO could effectively inhibit cell proliferation and reduce the production of intracellular lipids and inflammatory cytokines. Therefore, BFO can reduce the risk of hypercholesterolemia by maintaining cholesterol homeostasis, reducing vascular inflammation and alleviating macrophage foaming to prevent its further development into cardiovascular diseases.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105678"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3204066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect mechanism of polysaccharides inhibit tumor immune escape: A review","authors":"Kun Yang ,&nbsp;Jing Chen ,&nbsp;Jianping Chen ,&nbsp;Zhuo Wang ,&nbsp;Bingbing Song ,&nbsp;Rui Li ,&nbsp;Saiyi Zhong ,&nbsp;Kit-Leong Cheong","doi":"10.1016/j.jff.2023.105638","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105638","url":null,"abstract":"<div><p>A disorder of the immune system is the fundamental cause of cancer. The body can defend against external threats only when the immune system is robust. Polysaccharides are natural immune regulators that can regulate the immune function of the body at multiple levels and targets. Recent studies have shown that polysaccharides can inhibit tumor growth by stimulating the immune system, thereby promoting immune cell proliferation, increasing cytokine secretion, and regulating the immune functions of the body as a whole. However, there are few reports on the potential mechanism by which polysaccharides inhibit tumor immune escape. Therefore, this article reviews the immune anti-tumor effect of polysaccharides, the mechanism by which they inhibit tumor immune escape, and their signaling pathways, in order to provide a theoretical basis for the development of anti-tumor drugs and malignant tumor treatment.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105638"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3078368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction optimization and structural characterization of soluble dietary fiber in foxtail millet and its inhibitory activities on colon cancer","authors":"Aiqi Ren ,&nbsp;Liying Chen ,&nbsp;Wenjing Zhao ,&nbsp;Shuhua Shan ,&nbsp;Zhuoyu Li ,&nbsp;Zhaohui Tang","doi":"10.1016/j.jff.2023.105659","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105659","url":null,"abstract":"<div><p>Soluble dietary fiber has anti-tumor effect and is closely related to human health. At present the structure of soluble dietary fiber from foxtail millet (FMB-SDF) and its anti-tumor effect remain unclear. In this study, the structure of FMB-SDF was characterized, and its effects on the colon cancer were investigated. The results showed that under optimal extraction conditions the yield of FMB-SDF was 14.25 %. Based on the monosaccharide composition, methylation results and NMR analysis, the preliminary structure of FMB-SDF was inferred to be a glucan. Interestingly, FMB-SDF markedly inhibited the colony formation ability of HCT116 and HT-29 cells and could significantly induce the increase of reactive oxygen species (ROS) and apoptosis of HCT116 and HT-29 cells. The results of animal experiments showed that FMB-SDF could significantly alleviate clinical symptoms of colon cancer in mice. These results provide a theoretical basis for the exploitation and utilization of FMB-SDF against colon cancer.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105659"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3078372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microgreen: A tiny plant with superfood potential","authors":"Mahinder Partap ,&nbsp;Diksha Sharma ,&nbsp;Deekshith HN ,&nbsp;Meenakshi Thakur ,&nbsp;Vipasha Verma ,&nbsp;Ujala ,&nbsp;Bhavya Bhargava","doi":"10.1016/j.jff.2023.105697","DOIUrl":"10.1016/j.jff.2023.105697","url":null,"abstract":"<div><p>The design of novel and functional foods is a major driver of innovation in the food industry, which strives to meet consumer's rising demand and expectations for healthy foods. In recent years, microgreens have received popularity as functional foods due to their high-density nutrients and bioactive or secondary metabolite content. The morphology of microgreens is comprised of well-developed cotyledonalary leaves, immature true leaves, and a central stem. The scientific literature has documented numerous studies on microgreens such as nutritional content assessment, metabolite accumulation, nutraceutical potential, and shelf life enhancement. Physical, chemical, biological, and cultivation factors significantly increased the microgreen’s photosynthetic efficiency, growth, nutrient profile, antioxidant activity, and metabolite content. Using omics data, scientists have investigated the underlying molecular mechanism and potential gene(s) associated with nutrients, specialized metabolites, stress resistance, shelf-life enhancement, and disease resistance in nutraceutical plants.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105697"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1756464623002979/pdfft?md5=39e7f2d15b8b2c9ada56814b079fd054&pid=1-s2.0-S1756464623002979-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41468857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole red paprika (Capsicum annuum L.) and its orange-red pigment capsanthin ameliorate obesity-induced skeletal muscle atrophy in mice","authors":"Young In Kim ,&nbsp;Ji-Sun Kim ,&nbsp;Hyunjung Lee ,&nbsp;Chang Hwa Jung ,&nbsp;Jiyun Ahn","doi":"10.1016/j.jff.2023.105624","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105624","url":null,"abstract":"<div><p>Red paprika (RP) is rich in carotenoids and capsanthin (CS) is its main carotenoid. We determined whether whole RP and CS can ameliorate obesogenic sarcopenia.</p><p>C2C12 myotubes were co-treated with 500 μM of palmitic acid (PA) and 1 and 5 μg/mL RP or 0.5 and 1.0 μM CS for 24 h. Both RP and CS effectively attenuated PA-induced myotube atrophy. Male obese C57BL/6 mice (n = 40) were fed high-fat diets containing 5 and 10% RP or 0.025% CS for 10 weeks. Supplementation with RP and CS increased lean body mass, muscle performance, mtDNA content, and mitochondrial oxidative phosphorylation, while it decreased intracellular lipid accumulation in muscle tissue. Moreover, both RP and CS increased myosin heavy chains and decreased atrogens expression, which are associated with the activation of mTORC1 signaling. These results demonstrated that RP and CS protect against obesogenic sarcopenia by improving mitochondrial function.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105624"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1621612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaempferol relieves the DSS-induced chronic colitis in C57BL/6J mice, alleviates intestinal angiogenesis, and regulates colonic microflora structure","authors":"Ruyang Yu ,&nbsp;Qilyu Zhou ,&nbsp;Tianlong Liu ,&nbsp;Ping Liu ,&nbsp;Hong Li ,&nbsp;Yifei Bian ,&nbsp;Zhongjie Liu","doi":"10.1016/j.jff.2023.105646","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105646","url":null,"abstract":"<div><h3>Purpose</h3><p>The progression of chronic colitis is accompanied by an increase in inflammation and intestinal angiogenesis. Kaempferol, a dietary flavonoid, has been shown to exhibit anti-inflammatory and anti-angiogenic properties. However, the anti-angiogenic effect of kaempferol in chronic colitis has not been elucidated. The present study aimed to investigate the effects of kaempferol on intestinal angiogenesis and microflora of mice with chronic colitis.</p></div><div><h3>Methods</h3><p>The dextran sulfate sodium (DSS)-induced chronic colitis mouse model was used in this study. The effects of kaempferol and 5-aminosalicylic acid (5-ASA) were evaluated by histopathology, ELISA, western blot, and immunohistochemistry. The integrity of the gut-vascular barrier (GVB) was studied using FITC-dextran and D-Lactate. The colonic flora of mice was analyzed using 16S rDNA sequencing.</p></div><div><h3>Results</h3><p>Kaempferol supplementation could relieve the symptoms (weight loss, colonic pathological injury, hemogram index, etc.) of chronic colitis in mice, down-regulate the secretion of inflammatory factors (IL-1β, IL-6, TNF-α, and CRP), and modulate the expression of inflammatory regulatory proteins (COX-2, TRAF6, and IL-22BP) in colonic tissues. Moreover, kaempferol decreased the secretion of colonic VEGF and NO, high intestinal microvascular density (MVD), and abnormal expression of VEGFR2 caused by DSS. Our finding also indicated that kaempferol alleviates chronic colitis by maintaining GVB, suppressing pro-inflammatory flora (Verrucomicrobiota, Campilobacterota, and Desulfobacterota), and enhancing the abundance of beneficial flora (Actinobacteria, and <em>Odoribacter</em>).</p></div><div><h3>Conclusion</h3><p>Kaempferol exerted its therapeutic effect on chronic colitis by alleviating the inflammation of the colon and intestinal angiogenesis, maintaining the integrity of GVB, and regulating colonic microflora. Our study demonstrated similar pharmacological effects of kaempferol to 5-ASA (drug of clinical application for intestinal inflammatory diseases), and revealed the potential of kaempferol treatment as a preventive strategy for chronic colitis.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105646"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1621613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrobium huoshanense stem polysaccharide ameliorates high fructose-induced hepatocyte lipid accumulation through decreasing miR-429 to upregulate RIP2","authors":"Feng Li ,&nbsp;Lei-Lei Zhu ,&nbsp;Lei-Lei Gao ,&nbsp;Ying Pan ,&nbsp;Bang-Xing Han ,&nbsp;Ling-Dong Kong","doi":"10.1016/j.jff.2023.105632","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105632","url":null,"abstract":"<div><p><em>Dendrobium huoshanense</em> is an edible medicinal herb. Its stem polysaccharide (DHP) can alleviate hepatic injury, but the underlying mechanism is not fully understood. Receptor-interacting protein 2 (RIP2) is an important regulator in metabolic diseases. Here, we found that high fructose decreased RIP2 expression, and increased inositol-requiring enzyme-1α (IRE1α) and spliced X-box binding protein 1 (XBP1s) expression in cultured hepatocytes along with lipid accumulation, which were attenuated by DHP. RIP2 overexpression blocked high fructose-induced upregulation of IRE1α and XBP1s as well as hepatocyte lipid accumulation. RIP2 knockdown reversed amelioration effect of DHP on hepatocyte lipid accumulation. Furthermore, high fructose increased hepatocyte miR-429 expression targeting RIP2. MiR-429 inhibitor reversed high fructose-induced downregulation of RIP2 and lipid accumulation. Notably, DHP reduced miR-429 expression and increased RIP2 expression in its amelioration of lipid accumulation in this cell model. These results suggested that DHP protected against high fructose-induced hepatocyte lipid accumulation through downregulating miR-429 to upregulate RIP2 expression.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105632"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1757688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of Lactiplantibacillus pentosus CQZC01 on alcohol-induced gastric mucosa injury in mice via an anti-oxidative mechanism","authors":"Ya Wu ,&nbsp;Pan Wang ,&nbsp;Xingyao Long ,&nbsp;Xin Zhao","doi":"10.1016/j.jff.2023.105644","DOIUrl":"https://doi.org/10.1016/j.jff.2023.105644","url":null,"abstract":"<div><p>Gastric ulcer is a very common disease of the digestive system, and it is important to understand how this disease can be prevented and treated. In this study, the effects of <em>Lactiplantibacillus pentosus</em> CQZC01 (LP-CQZC01) on alcohol-induced gastric mucosal injury were investigated by evaluating the extent of hemorrhage and edema, as well as cell necrosis and gastric mucosal cell shedding. In addition, the levels of oxidative stress-related indicators, gastric mucosal defense factors, and pro-inflammatory cytokines were measured. After treatment with LP-CQZC01, the area of gastric mucosal damage was significantly reduced, and the ulcer inhibition rate and the extent of gastric mucosal damage were improved. LP-CQZC01 also significantly increased the levels of somatostatin (SS) and prostaglandin E2 (PGE2), as well as the levels of superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-Px); however, it decreased the malondialdehyde (MDA) content, thereby improving the anti-oxidant capacity. In addition, the levels of pro-inflammatory cytokines, such as interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha (TNF-α), were decreased, and the anti-inflammatory factor IL-10 was elevated. The results of polymerase chain reactions revealed that LP-CQZC01 activated the nuclear factor E2-related factor 2 (Nrf2) signaling pathway, thereby increasing the levels of downstream genes γ-glutamyl cysteine synthetase (<em>γ-GCS</em>), <em>SOD</em>, catalase (<em>CAT</em>), and <em>GSH-Px</em>. In summary, LP-CQZC01 can alleviate alcohol-induced gastric mucosal damage by increasing the levels of gastric mucosal defense factors, inhibiting oxidative stress, and suppressing inflammation. Therefore, LP-CQZC01 is a potential therapeutic agent for the prevention and treatment of alcohol-induced gastric mucosal injury.</p></div>","PeriodicalId":360,"journal":{"name":"Journal of Functional Foods","volume":"107 ","pages":"Article 105644"},"PeriodicalIF":5.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"1757693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}