Phellinus igniarius alcohol extract restores the immune homeostasis in cyclophosphamide induced immunocompromised mice

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-05-08 DOI:10.1016/j.jff.2025.106861

Anni Xie , Fang He , Li Wang , Wenjing Shi , Panling Xu , Ting Wang , Ping Li

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Abstract

It is common for cancer patients to experience immune dysfunction after chemotherapy, which increases their risk of infection and tumor recurrence. Restoring immune homeostasis is therefore of great importance. Phellinus igniarius's role in restoring immune homeostasis is unclear. This study conducts mass spectrometry analysis on Phellinus igniarius alcohol extract to identify its main components, and then conducts animal experiments to clarify the effects of Phellinus igniarius alcohol extract on the immunocompromised mice induced by cyclophosphamide, observing the changes on mice state, immune organs indices, CD4+/CD8+ T cells ratio, immune cells functions, and cytokines secretion. Phellinus igniarius alcohol extract (P-AE) exhibited a dose-dependent trend in restoring immune homeostasis in cyclophosphamide-induced immunocompromised mice. Compared to the cyclophosphamide group, the P-AE-1000 group mice showed significant differences in vitality, immune organs indices, CD4+/CD8+ T cells ratio, immune cells functions, and cytokines secretion. This study found that Phellinus igniarius alcohol extract could increase the ratio of CD4+/CD8+ T cells, improve the level of cytokines secretion, and rebuild the immune homeosta of immunocompromised mice.

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黄连醇提取物可恢复环磷酰胺诱导的免疫功能低下小鼠的免疫稳态

癌症患者在化疗后出现免疫功能障碍是很常见的，这增加了他们感染和肿瘤复发的风险。因此，恢复免疫稳态非常重要。黄菌在恢复免疫稳态中的作用尚不清楚。本研究通过质谱分析对黄连醇提物进行鉴定，确定其主要成分，并通过动物实验明确黄连醇提物对环磷酰胺诱导的免疫功能低下小鼠的影响，观察其对小鼠状态、免疫器官指标、CD4+/CD8+ T细胞比例、免疫细胞功能、细胞因子分泌的变化。茴香醇提取物（P-AE）对环磷酰胺诱导的免疫功能受损小鼠的免疫稳态恢复有剂量依赖性。与环磷酰胺组相比，P-AE-1000组小鼠在活力、免疫器官指数、CD4+/CD8+ T细胞比例、免疫细胞功能、细胞因子分泌等方面均有显著差异。本研究发现，茶树醇提物可提高免疫功能低下小鼠的CD4+/CD8+ T细胞比例，提高细胞因子分泌水平，重建免疫稳态。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.