The effect of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women: A double-blinded randomized clinical trial

IF 3.8 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Journal of Functional Foods Pub Date : 2025-05-27 DOI:10.1016/j.jff.2025.106906

Gu Yuming , Lu Zhejun , Sun Longyu , Zong Chenyu , Han Qinglin

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引用次数: 0

Abstract

Background

This study evaluated the effects of synbiotic supplementation on anthropometric indices and bone metabolism in postmenopausal women.

Methods

In this randomized, double-blind, placebo-controlled trial, 52 postmenopausal women were received synbiotic or placebo for six months. Anthropometric measurements, bone mineral density (BMD), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), C-terminal telopeptide of type I collagen (CTX), procollagen type I N-terminal propeptide (P1NP), tartrate-resistant acid phosphatase 5b (TRAP-5b), and bone-specific alkaline phosphatase (BSAP) were assessed.

Results

Although there were no considerable differences in BMI, fat mass, or BMD between groups, a significant decrease was observed in the synbiotic group regarding visceral fat content (p = 0.004), TRAP-5b (p < 0.001), BSAP (p = 0.003), and CTX (p = 0.028). No substantial changes were observed in OPG, RANKL, OC, or P1NP (p > 0.05).

Conclusion

Synbiotic supplementation significantly reduced visceral fat and markers of bone resorption in postmenopausal women.

Clinical trial registration: ChiCTR2300076114.

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合成补充剂对绝经后妇女人体测量指标和骨代谢的影响：一项双盲随机临床试验

本研究评估了合成补充剂对绝经后妇女人体测量指标和骨代谢的影响。方法在这项随机、双盲、安慰剂对照试验中，52名绝经后妇女接受了6个月的合成或安慰剂治疗。评估了人体测量、骨矿物质密度（BMD）、骨保护素（OPG）、核因子κ κ受体激活剂-Β配体（RANKL）、I型胶原c端端肽（CTX）、I型前胶原n端前肽（P1NP）、抗酒石酸酸性磷酸酶5b （TRAP-5b）和骨特异性碱性磷酸酶（BSAP）。结果：虽然两组之间BMI、脂肪量和骨密度没有显著差异，但合成组内脏脂肪含量显著降低（p = 0.004）， TRAP-5b (p <；0.001)、BSAP （p = 0.003）和CTX （p = 0.028）。OPG、RANKL、OC或P1NP未见明显变化(p >；0.05)。结论补充益生菌可显著降低绝经后妇女内脏脂肪和骨吸收指标。临床试验注册：ChiCTR2300076114。

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来源期刊

Journal of Functional Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

428

审稿时长

76 days

期刊介绍： Journal of Functional Foods continues with the same aims and scope, editorial team, submission system and rigorous peer review. We give authors the possibility to publish their top-quality papers in a well-established leading journal in the food and nutrition fields. The Journal will keep its rigorous criteria to screen high impact research addressing relevant scientific topics and performed by sound methodologies. The Journal of Functional Foods aims to bring together the results of fundamental and applied research into healthy foods and biologically active food ingredients. The Journal is centered in the specific area at the boundaries among food technology, nutrition and health welcoming papers having a good interdisciplinary approach. The Journal will cover the fields of plant bioactives; dietary fibre, probiotics; functional lipids; bioactive peptides; vitamins, minerals and botanicals and other dietary supplements. Nutritional and technological aspects related to the development of functional foods and beverages are of core interest to the journal. Experimental works dealing with food digestion, bioavailability of food bioactives and on the mechanisms by which foods and their components are able to modulate physiological parameters connected with disease prevention are of particular interest as well as those dealing with personalized nutrition and nutritional needs in pathological subjects.