Animal Reproduction Science最新文献

Characterizing pregnancy losses in lactating Holstein cows receiving a fixed-timed artificial insemination protocol 接受固定时间人工授精方案的荷斯坦泌乳奶牛的妊娠损失特征。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-13 DOI: 10.1016/j.anireprosci.2024.107644

A.K. Munhoz , R.F. Cooke , C.P. Prado , S.K. Munhoz , M.C.G. de Sousa , V.M.P. da Silva , K.G. Pohler , B.I. Cappellozza , J.L.M. Vasconcelos

{"title":"Characterizing pregnancy losses in lactating Holstein cows receiving a fixed-timed artificial insemination protocol","authors":"A.K. Munhoz , R.F. Cooke , C.P. Prado , S.K. Munhoz , M.C.G. de Sousa , V.M.P. da Silva , K.G. Pohler , B.I. Cappellozza , J.L.M. Vasconcelos","doi":"10.1016/j.anireprosci.2024.107644","DOIUrl":"10.1016/j.anireprosci.2024.107644","url":null,"abstract":"<div><div>This experiment assessed pregnancy losses from day 31 of gestation to calving in lactating Holstein cows reared in tropical conditions, and evaluated if serum concentrations of haptoglobin and pregnancy-associated glycoproteins (<strong>PAGs</strong>) during early gestation differs according to pregnancy losses. Cows (708 primiparous and 844 multiparous) were assigned to an ovulation synchronization + fixed-time artificial insemination (<strong>FTAI</strong>) protocol (day −11–0 of the experiment). Pregnancy status was verified using transrectal ultrasonography on days 31, 62, 120, and according to calf birth. Blood samples were collected from all cows on day 24, and from cows diagnosed as pregnant on day 31. Pregnancy losses were greater (<em>P</em> < 0.01) from day 31–62 (12.8 %) and day 120 to calving (12.1 %) compared with day 62–120 (6.42 %). Pregnancy losses were greater in multiparous compared with primiparous cows from day 31–62 (17.1 vs. 9.5 %) and from 120 to calving (15.4 vs. 7.7 %). Serum PAGs concentrations on day 31 were less (<em>P</em> ≤ 0.03) in cows that lost the pregnancy from day 31–62 (3.57 ng/mL) and from day 62–120 (4.40 ng/mL) compared to cows that maintained the pregnancy (5.57 and 5.66 ng/mL, respectively). Cows that experienced pregnancy loss from day 31–62 had greater (<em>P</em> = 0.05) serum haptoglobin concentrations on day 24 (0.414 mg/mL) compared with cows that maintained the pregnancy (0.271 mg/mL). Collectively, this experiment provides novel information about pregnancy losses after day 31 of gestation in lactating Holstein cows reared in tropical environments.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"272 ","pages":"Article 107644"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarker-based high-throughput sperm phenotyping: Andrology in the age of precision medicine and agriculture 基于生物标记的高通量精子表型分析：精准医疗和农业时代的男性学。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-08 DOI: 10.1016/j.anireprosci.2024.107636

Filip Tirpak , Lauren E. Hamilton , Robert D. Schnabel , Peter Sutovsky

{"title":"Biomarker-based high-throughput sperm phenotyping: Andrology in the age of precision medicine and agriculture","authors":"Filip Tirpak , Lauren E. Hamilton , Robert D. Schnabel , Peter Sutovsky","doi":"10.1016/j.anireprosci.2024.107636","DOIUrl":"10.1016/j.anireprosci.2024.107636","url":null,"abstract":"<div><div>Reproductive efficiency is crucial for animal agriculture. This economically important aspect can be influenced by environmental burdens, nutritional imbalance, and gonadal or gametic malformations of genetic origin. Successful implementation of genomic-driven selective breeding in cattle depends on the reproductive performance of artificial insemination (AI) sires with valuable genomic production traits. Reproduction is traditionally viewed as a complex set of polygenic traits that are negatively impacted by using a small number of often closely related sires selected for AI due to their superior genetics. Despite recent progress, it remains difficult to define relationships between sire genome and variation in sperm phenotypes, even though several types of heritable, non-compensable sperm defects have been identified. In this review, we discuss the concept of sperm quality biomarker discovery and genomics of male fertility. We also outline a multidisciplinary genome-to-phenome approach for investigating heritable mutations and their impacts on bull fertility, sperm phenotypes and paternal contributions to early pregnancy. High-precision phenotyping requires novel, state-of-the-art instrumentation for sperm quality evaluation and development of new biomarkers of sperm quality in farm animals, with potential for incorporation into andrology-specific machine learning protocols and translation to human andrology. We conclude that reproduction is a complex phenotype that can be deciphered and explored for more precise male fertility evaluation and higher reproductive efficiency.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107636"},"PeriodicalIF":2.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male reproductive biotechnologies in South American Camelids Part I: Semen collection, evaluation and handling 南美洲驼科动物雄性生殖生物技术第一部分：精液采集、评估和处理。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-06 DOI: 10.1016/j.anireprosci.2024.107634

María Ignacia Carretero , Susana María Giuliano , Marcelo Horacio Miragaya , Deborah Margarita Neild

引用次数: 0

Genetic insights into litter size in goats: A meta-analysis of KISS1 and BMP15 SNP variants 山羊产仔数的遗传学研究：KISS1和BMP15 SNP变异的荟萃分析。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-06 DOI: 10.1016/j.anireprosci.2024.107632

Mohsen Gholizadeh, Mehre Mohammadnezhad

{"title":"Genetic insights into litter size in goats: A meta-analysis of KISS1 and BMP15 SNP variants","authors":"Mohsen Gholizadeh, Mehre Mohammadnezhad","doi":"10.1016/j.anireprosci.2024.107632","DOIUrl":"10.1016/j.anireprosci.2024.107632","url":null,"abstract":"<div><div>Litter size is a key trait in livestock breeding. The <em>BMP15</em> and <em>KISS1</em> genes have been studied in goats, but results on their association with litter size are inconsistent. The objective of this study was to employ a meta-analysis approach to investigate the genetic relationship between the <em>BMP15</em> (<em>g</em>.735 <em>G</em>><em>A</em>) and <em>KISS1</em> (<em>g</em>.2540 <em>C</em>><em>T</em> and g.2510 <em>G</em>><em>A</em>) genes and litter size in goats. A total of five studies (including 12 breeds) were included for the <em>g</em>.735 <em>G</em>><em>A</em> mutation, three studies (including nine breeds) for <em>g</em>.2540 <em>C</em>><em>T</em>, and two studies (including six breeds) for <em>g</em>.2510 <em>G</em>><em>A</em> in this meta-analysis. The meta-analysis was conducted under four different genetic models: recessive (<em>GG</em> + <em>AG</em> vs. <em>AA</em>), dominant (<em>GG</em> vs. <em>AG</em> + <em>AA</em>), additive (<em>GG</em> vs. <em>AA</em>) and codominant (<em>GG</em> + <em>AA</em> vs. <em>AG</em>) models of inheritance. Data were analyzed under either random or fixed effects models based on the estimates of <em>I</em><sup>2</sup> estimates. A sensitivity analysis was performed by removing one study at a time to determine the stability of the overall results. Funnel plots and the Egger regression tests were also used to assess the publication bias among studies. Significant associations (<em>P<</em> 0.05) were observed between the g.2540 <em>C</em>><em>T</em> and g.2510 <em>G</em>><em>A</em> loci and litter size in goats under the additive (SMD = −0.469, 95 % CI = −0.908 to −0.030, <em>P-</em>value = 0.036) and codominant (SMD = 0.147, 95 % CI = 0.003–0.291, <em>P</em> = 0.046) genetic models, respectively. Our results did not identify any significant association between g.735 <em>G</em>><em>A</em> of <em>BMP15</em> and litter size under the investigated genetic models.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107632"},"PeriodicalIF":2.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of stallion spermatozoa metabolism using Agilent Seahorse XFp Technology 使用安捷伦海马 XFp 技术分析种马精子的新陈代谢。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-03 DOI: 10.1016/j.anireprosci.2024.107633

Jose Manuel Ortiz-Rodriguez , Diego Bucci , Laura Tovar-Pascual , Silvia Granata , Marcella Spinaci , Salvatore Nesci

{"title":"Analysis of stallion spermatozoa metabolism using Agilent Seahorse XFp Technology","authors":"Jose Manuel Ortiz-Rodriguez , Diego Bucci , Laura Tovar-Pascual , Silvia Granata , Marcella Spinaci , Salvatore Nesci","doi":"10.1016/j.anireprosci.2024.107633","DOIUrl":"10.1016/j.anireprosci.2024.107633","url":null,"abstract":"<div><div>Sperm metabolism consists of a sophisticated network of biochemical reactions and varies between species, resulting in different metabolic strategies for ATP production to maintain sperm functionality. ATP can be produced through glycolysis or in the mitochondria by oxidative phosphorylation (OXPHOS). Since OXPHOS is the predominant metabolic pathway in horses spermatozoa, various assessments of mitochondrial activity are used to evaluate fertility, utilizing techniques such as fluorescent probes analysed via microscopy or flow cytometry, and polarographic electrode assays to measure current flow in response to an applied voltage. Though, these methods are limited by low throughput, as they assess mitochondrial activity at a single time point under a specific treatment condition. This study explores, for the first time, the application of the Agilent Seahorse XFp Technology to evaluate metabolism in stallion spermatozoa. This method enables real-time measurement of cellular metabolism across multiple samples or experimental conditions simultaneously. Ejaculates from eight different stallions were collected, and pools were prepared from three of them. Sperm viability and mitochondrial activity were evaluated by fluorescence microscopy, sperm motility by a computer-assisted sperm analysis system, and sperm metabolism was analysed via the Seahorse XFp analyser. Results confirmed a preference for OXPHOS over glycolysis in ATP production in stallion sperm, with mitochondria contributing significantly to total ATP generation. The Seahorse XFp Technology proved effective in evaluating equine sperm bioenergetics, offering insights into metabolic pathways critical for sperm function. In conclusion, this technology grants a new method for high-throughput analysis of sperm metabolism and quality, which could be applied to future reproductive studies in male equine fertility.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107633"},"PeriodicalIF":2.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early apoptosis detection in canine granulosa cells through the analysis of BCL-2 and BAX proteins during the follicular development associated with oocyte maturation 通过分析与卵母细胞成熟相关的卵泡发育过程中的 BCL-2 和 BAX 蛋白，检测犬颗粒细胞的早期凋亡。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-02 DOI: 10.1016/j.anireprosci.2024.107635

Michelle Salinger , Jaime Palomino , Oscar A Peralta , Victor H. Parraguez , Monica De los Reyes

{"title":"Early apoptosis detection in canine granulosa cells through the analysis of BCL-2 and BAX proteins during the follicular development associated with oocyte maturation","authors":"Michelle Salinger , Jaime Palomino , Oscar A Peralta , Victor H. Parraguez , Monica De los Reyes","doi":"10.1016/j.anireprosci.2024.107635","DOIUrl":"10.1016/j.anireprosci.2024.107635","url":null,"abstract":"<div><div>The objective of this study was to investigate the early follicular apoptosis in canine ovarian follicles by examining the expression of anti-apoptotic BCL-2 and pro-apoptotic BAX proteins throughout the estrous cycle associated with oocyte maturation. Follicular cells from preantral and antral follicles of varying sizes were isolated and grouped based on follicle type and estrous phase. Antral follicles underwent flow cytometry analysis, whereas preantral follicles were subjected to Western blotting. The meiotic capacity of oocytes from these different follicle types was evaluated through in vitro maturation. Statistical analysis included ANOVA and Duncan’s test. Results showed fluctuations in BCL-2 and BAX levels across different follicular stages and estrous phases. BCL-2 levels increased (<em>P</em><0.05) with follicular development in antral follicles, particularly during estrus, while BAX exhibited variations peaking (<em>P</em><0.05) during estrus. The BCL-2/BAX ratio in antral follicles was higher (<em>P</em><0.05) in estrus and diestrus compared to anestrus and proestrus. Additionally, BCL-2 and BAX proteins were detected in preantral follicles, with varying expression levels (<em>P</em><0.05) across estrous phases. The BCL-2/BAX ratio in preantral follicles was highest (<em>P</em><0.05) during anestrus and estrus and decreased (<em>P</em><0.05) in proestrus and diestrus. Oocytes from preantral follicles did not reach the MII stage, regardless of the levels of BCL-2/BAX. Conversely, oocytes obtained from large follicles during estrus showed the highest (<em>P</em><0.05) maturation percentages, which were associated with the highest BCL-2/BAX ratio. These findings provide insights into the dynamic patterns of BCL-2 /BAX in canine follicles across the estrous cycle, shedding light on their potential roles in oocyte development.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107635"},"PeriodicalIF":2.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Manipulation of metabolism to improve liquid preservation of mammalian spermatozoa 操纵新陈代谢以改善哺乳动物精子的液态保存。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-11-02 DOI: 10.1016/j.anireprosci.2024.107631

Madeleine Van de Hoek, Jessica P. Rickard, Simon P. de Graaf

{"title":"Manipulation of metabolism to improve liquid preservation of mammalian spermatozoa","authors":"Madeleine Van de Hoek, Jessica P. Rickard, Simon P. de Graaf","doi":"10.1016/j.anireprosci.2024.107631","DOIUrl":"10.1016/j.anireprosci.2024.107631","url":null,"abstract":"<div><div>Reproductive success in mammals hinges on the ability of sperm to generate sufficient energy through cellular metabolism to perform the energy-intensive processes required for fertilisation, including motility, maturation, and oocyte interactions. It is now widely accepted that sperm exhibit metabolic flexibility, utilising a combination of glycolysis and oxidative phosphorylation (supported by the Krebs cycle and other complementary pathways) to meet their energy demands. However, the preferred pathway for energy production varies significantly among species, making it challenging to map species-specific metabolic strategies, particularly in species with high metabolic flexibility, like the ram. Additionally, differences in methodologies used to measure metabolism have led to biased interpretations of species’ metabolic strategies, complicating the development of liquid storage methods aimed at preserving spermatozoa by manipulating energy generation based on species-specific requirements. This review examines sperm energy requirements, current methods for assessing metabolic capacity, and the current research on species-specific metabolism. Future research should focus on establishing a standardised approach for determining metabolic preferences to accurately map species-specific strategies, a critical step before developing effective liquid preservation methods. By identifying species-specific regulatory points, strategies can be designed to temporarily inhibit metabolic pathways, conserving resources and reducing the accumulation of metabolic by-products. Alternatively, supplementation with depleted metabolites can be guided by understanding areas of excessive consumption during prolonged metabolism. Applying this knowledge to develop tailored preservation techniques will help minimise sperm damage and improve survival during <em>in vitro</em> processing and liquid storage, ultimately enhancing the success of artificial breeding programs.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107631"},"PeriodicalIF":2.2,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomics of bovine sperm and oocytes 牛精子和卵母细胞的转录组学

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-10-30 DOI: 10.1016/j.anireprosci.2024.107630

Vanmathy Kasimanickam , John Kastelic , Ramanathan Kasimanickam

引用次数: 0

Sustainable captive breeding practices for native Indonesian freshwater fish 印度尼西亚本土淡水鱼的可持续人工繁殖方法

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-10-28 DOI: 10.1016/j.anireprosci.2024.107623

Darmawan Setia Budi , Agus Priyadi , Asep Permana , Muh. Herjayanto , Jacques Slembrouck , Ahmad Shofy Mubarak , Imam Mustofa

{"title":"Sustainable captive breeding practices for native Indonesian freshwater fish","authors":"Darmawan Setia Budi , Agus Priyadi , Asep Permana , Muh. Herjayanto , Jacques Slembrouck , Ahmad Shofy Mubarak , Imam Mustofa","doi":"10.1016/j.anireprosci.2024.107623","DOIUrl":"10.1016/j.anireprosci.2024.107623","url":null,"abstract":"<div><div>In Indonesia, the over-exploitation and habitat degradation of its biodiverse freshwater fish populations, has led to an urgent need for conservation of endangered fish species. A review is conducted on sustainable captive breeding practices for native Indonesian freshwater fish, with emphasis placed on the importance of ex situ conservation strategies. The key components of captive breeding such as ecological and biological research in the field; capturing, handling, and transportation of fish; selection of genetically diverse breeding stock; care and quarantine measures; feed acclimatization; and creation of reproductive facilities have been discussed. Natural, artificial, and semi-natural breeding methods have also been reviewed, and their advantages and limitations have been highlighted. The challenges in maintaining genetic diversity, managing health, ensuring successful acclimatization, and facilitating reproduction have been identified, and strategies to overcome them have been proposed. By integrating conservation and economic objectives, this review underscores the dual role of captive breeding in preserving endangered species and enhancing the ornamental fish trade, thereby contributing to the sustainable management of Indonesia's freshwater fish resources. This review adds to the literature by offering a comprehensive synthesis of sustainable captive breeding practices for native Indonesian freshwater fish, filling a critical gap in global conservation efforts and providing practical recommendations for similar initiatives worldwide.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107623"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental programming of reproduction in sheep and goat: Association of fraternity size and sex ratio with reproductive performance of ewes and does at the first pregnancy 绵羊和山羊的生殖发育程序：兄弟会规模和性别比例与母羊和初孕母羊繁殖性能的关系。

IF 2.2 2区农林科学

Animal Reproduction Science Pub Date : 2024-10-25 DOI: 10.1016/j.anireprosci.2024.107622

Emadeddin Mobedi , Mehdi Vojgani , Faramarz Gharagozlou , Tooba Aghaei , Reza Darabian Aghdas , Reza Hemmati Baghbanani , Amirsina Akbarinejad , Vahid Akbarinejad

{"title":"Developmental programming of reproduction in sheep and goat: Association of fraternity size and sex ratio with reproductive performance of ewes and does at the first pregnancy","authors":"Emadeddin Mobedi , Mehdi Vojgani , Faramarz Gharagozlou , Tooba Aghaei , Reza Darabian Aghdas , Reza Hemmati Baghbanani , Amirsina Akbarinejad , Vahid Akbarinejad","doi":"10.1016/j.anireprosci.2024.107622","DOIUrl":"10.1016/j.anireprosci.2024.107622","url":null,"abstract":"<div><div>Various prenatal factors including the number of littermates (fraternity size) and exposure to male littermate (fraternity sex ratio) during fetal period have been reported to influence postnatal fertility in the mammals. The present research was conducted to study the association of fraternity size and sex ratio with reproductive performance of nulliparous ewes and does. To this end, data associated with number of littermates, exposure to male littermate, birth weight, age at first pregnancy, as well as litter size, sex ratio of offspring, litter weight, and birth weight of female and male offspring after the first parturition retrieved from the database of sheep (n = 536 Romane and 289 Blanche du Massif Central ewes) and goat (n = 174 Alpine and 267 Saanen does) flocks. Fraternity size was negatively associated with birth weight of ewes and does (<em>P</em> < 0.05). Exposure to male littermate during fetal period was associated with younger age at first pregnancy and larger litter size in the does (<em>P</em> < 0.05), but not in the ewes (<em>P</em> > 0.05). Exposure to male littermate during fetal period was positively associated with the odds of male-biased litters in the ewes and does (<em>P</em> < 0.05). Fraternity size was positively associated with litter weight in the does (<em>P</em> < 0.05), but not in the ewes (<em>P</em> > 0.05). In conclusion, the present study showed that the number and sex of littermates during fetal period could impact postnatal reproduction of ewes and does. In this context, some associations, particularly those related to exposure to male littermate during fetal period, were only observed in does, which implicates that the effect of androgens on developmental programming of reproduction may be species-specific.</div></div>","PeriodicalId":7880,"journal":{"name":"Animal Reproduction Science","volume":"271 ","pages":"Article 107622"},"PeriodicalIF":2.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142543220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0