Molecular Nutrition & Food Research最新文献

Neuroprotective Effect of β-1,3-Glucans-Rich Euglena gracilis Against Ischemic Stroke in Middle-Aged Mice Fed With a High-Fat-High-Fructose Diet. 富含β-1,3-葡聚糖的股薄草对高脂高果糖饮食喂养的中年小鼠缺血性中风的神经保护作用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-19 DOI: 10.1002/mnfr.70084

Haoxie Xu,Ya-Chao Wang,Xiangzhu Li,Xuli Wu,Kang Liu,Mingfu Wang,Bin Liu,Hui Xu,Jie-Hua Chen,Ka-Wing Cheng

{"title":"Neuroprotective Effect of β-1,3-Glucans-Rich Euglena gracilis Against Ischemic Stroke in Middle-Aged Mice Fed With a High-Fat-High-Fructose Diet.","authors":"Haoxie Xu,Ya-Chao Wang,Xiangzhu Li,Xuli Wu,Kang Liu,Mingfu Wang,Bin Liu,Hui Xu,Jie-Hua Chen,Ka-Wing Cheng","doi":"10.1002/mnfr.70084","DOIUrl":"https://doi.org/10.1002/mnfr.70084","url":null,"abstract":"Ischemic stroke leads to significant neurological deficits and remains a leading cause of disability and mortality worldwide. β-1,3-glucans-rich Euglena gracilis (EG), a type of dietary supplement, was reported to regulate metabolic perturbation and the gut-brain axis that have been implicated in aggravation of the disease. The present study aimed to investigate the neuroprotective effects of EG supplementation in an ischemic stroke model in middle-aged mice fed with a high-fat high-fructose (HFHF) diet. The mice were divided into three groups: HFHF, HFHF+EG (HFHF_EG), and HFHF+Sham (HFHF_Sham). After 8 weeks of dietary intervention, ischemic stroke was induced via middle cerebral artery occlusion (MCAO) in the HFHF and HFHF_EG groups. The data revealed that EG supplementation significantly reduced infarct volume, alleviated neurological deficits, and enhanced synaptic plasticity in the hippocampus. The neuroprotective effects of EG were associated with improved intestinal barrier integrity, reduced systemic and neuroinflammation, and modulation of the hippocampal insulin signaling pathway. Furthermore, EG supplementation favorably altered gut microbiota composition, especially enhancing the relative abundance of beneficial bacteria and short-chain fatty acid production. Our results suggest that EG supplementation may be a promising dietary strategy to mitigate HFHF diet-induced exacerbation of ischemic stroke via the gut-brain axis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"1 1","pages":"e70084"},"PeriodicalIF":5.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shielding Human Adipocytes From Inflammation: The Protective Potential of Polyphenol-Rich Opuntia ficus-indica Cladode Extract. 保护人体脂肪细胞免受炎症：富含多酚的无花果树提取物的保护潜力。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-16 DOI: 10.1002/mnfr.70114

Stefano Quarta,Nadia Calabriso,Maria Annunziata Carluccio,Clara Albano,Ibrahim Khalifa,Martin Wabitsch,Federica Blando,Marika Massaro

{"title":"Shielding Human Adipocytes From Inflammation: The Protective Potential of Polyphenol-Rich Opuntia ficus-indica Cladode Extract.","authors":"Stefano Quarta,Nadia Calabriso,Maria Annunziata Carluccio,Clara Albano,Ibrahim Khalifa,Martin Wabitsch,Federica Blando,Marika Massaro","doi":"10.1002/mnfr.70114","DOIUrl":"https://doi.org/10.1002/mnfr.70114","url":null,"abstract":"Opuntia ficus-indica (OFI) has attracted much attention as a source of antioxidant and antiinflammatory compounds. We hypothesize that the antioxidant content of OFI cladode extract may improve adipocyte dysfunction resulting from inflammatory stimulation of hypertrophic adipocytes. To this end, the properties of OFI cladode hydroalcoholic extract were evaluated in terms of antioxidant activity, regulation of adipocyte inflammation, and adipocyte/monocyte interaction in human adipocytes rendered dysfunctional by the proinflammatory cytokine tumor necrosis factor-α (TNF-α). The major phenolic compounds identified were isorhamnetin derivatives and phenolic acids, including piscidic and eucomic acids. Our results show that OFI cladode extract exhibits antiradical activities and reduces the adhesion and transmigration activity of monocytes to inflamed adipocytes by inhibiting various cytokines, chemokines, and adhesion molecules such as interleukin (IL)-6 and IL-8 by ∼80%, monocyte chemotactic protein (MCP)-1, C-X-C motif chemokine ligand (CXC-L)10, macrophage colony-stimulating factor (M-CSF) from 40% to 50%, and intercellular adhesion molecule-1 (ICAM-1) by 70% at the higher concentration. In structurally and mechanistically by protein-ligand docking profiling study, piscidic acid proved to be the best potential candidate for a regulatory interaction with the activities of nuclear factor erythroid 2-related factor 2 (NRF-2) and nuclear factor-κB (NF-κB). In summary, these data highlight the potential of OFI as a dietary supplement in nutritional treatments aimed at combating the inflammatory stigmata of obesity.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"30 1","pages":"e70114"},"PeriodicalIF":5.2,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications. 血管生成作为（多）酚的治疗靶点：治疗癌症和血管相关并发症。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-15 DOI: 10.1002/mnfr.70110

María Ángeles Ávila-Gálvez,Antonio Vico-Padilla,Claus Schneider,Juan Carlos Espín,Antonio González-Sarrías,Juan Antonio Giménez-Bastida

{"title":"Angiogenesis as a Therapeutic Target of (Poly)phenols: Tackling Cancer and Vascular-Related Complications.","authors":"María Ángeles Ávila-Gálvez,Antonio Vico-Padilla,Claus Schneider,Juan Carlos Espín,Antonio González-Sarrías,Juan Antonio Giménez-Bastida","doi":"10.1002/mnfr.70110","DOIUrl":"https://doi.org/10.1002/mnfr.70110","url":null,"abstract":"Targeting angiogenesis as a strategy for treating cancer or vascular-associated complications is an inspiring field for many investigators. An active area within this discipline is the search for agents capable of modulating angiogenesis in order to ameliorate its structural and functional abnormalities associated with these diseases. (Poly)phenols are a broad group of molecules, many of which fall within the category of natural compounds with therapeutic potential. These potential medicinal effects have launched a considerable number of studies investigating the pro- and(or) anti-angiogenic properties of (poly)phenols in different (patho)physiological settings. The purpose of this review is to summarize the current evidence of the role of (poly)phenols in modulating angiogenesis. This review will guide the reader through preclinical and human investigations describing the pro- and anti-angiogenic effects of these compounds in different pathophysiological context, the cellular and molecular mechanisms associated, the key points in the design and evaluation of the effects described, and suggest new approaches to be considered in future studies to overcome the current limitations.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"25 1","pages":"e70110"},"PeriodicalIF":5.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Effect of Abscisic Acid on MPTP-Induced Parkinson's Disease in Mice 脱落酸对mptp诱导的小鼠帕金森病的神经保护作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-13 DOI: 10.1002/mnfr.70111

Zhengjia Yang, Tingting Liu, Xiangrui Kong, Jianshe Wei

{"title":"Neuroprotective Effect of Abscisic Acid on MPTP-Induced Parkinson's Disease in Mice","authors":"Zhengjia Yang, Tingting Liu, Xiangrui Kong, Jianshe Wei","doi":"10.1002/mnfr.70111","DOIUrl":"https://doi.org/10.1002/mnfr.70111","url":null,"abstract":"Parkinson's disease (PD) is the second largest neurodegenerative disease after Alzheimer's disease (AD), and neuroinflammation is one of its important causes. So far, there is no clear evidence that drugs can improve the onset of PD, so it is crucial to find and develop effective drugs for PD treatment. Abscisic acid (ABA) is a phytohormone with structural and medicinal functions similar to the PPAR-γ agonist thiazolidinedione drugs (TZDs). It has played therapeutic effects in a variety of inflammatory diseases, but the role and mechanism of PD have not been defined. The present study aimed to gain insight into the neuroprotection effects and mechanism of ABA in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced PD models. In this study, we observed that in addition to significant behavioral abnormalities in MPTP-induced mice, Inflammatory parameters such as ion calcium-binding adaptor molecule 1 (IBA-1), glial fibrillary acid protein (GFAP), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) were also significantly increased in substantia nigra pars compacta (SNpc). ABA treatment restored behavioral abnormalities and significantly reduced these inflammatory parameters in MPTP-induced mice. Interestingly, these effects were not related to the activation of the lanthionine synthetase C-like protein 2 (LANCL2) but were related to the regulation of the peroxisome proliferator-activated receptor gamma (PPAR-γ). Intraperitoneal injection of ABA ameliorated the MPTP-induced increase in PPAR-γ and peroxisome proliferator-activated receptor co-activator-1α (PGC-1α) expression. Our findings suggest that intraperitoneal injection of ABA is neuroprotective against neurodegeneration induced by MPTP, and this effect is associated with the downregulation of neuroinflammation and modulation of the expression of PPAR-γ and PGC-1α. These results suggest that ABA is expected to develop as a therapeutic candidate for PD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"124 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143940176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Plant-Based Diet and Continuous Glucose Monitoring-Derived Glycemic Dynamics Among Pregnant Women With Gestational Diabetes. 植物性饮食与妊娠期糖尿病孕妇持续血糖监测之间的关系

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-13 DOI: 10.1002/mnfr.70085

Meng Ye,Congmei Xiao,Meiqi Shi,Sha Lu,Xinxiu Liang,Zelei Miao,Ke Zhang,Wanglong Gou,Jingnan Chen,Jiali Wang,Xuhong Wang,Sirithon Siriamornpun,Wensheng Hu,Ju-Sheng Zheng,Yuanqing Fu

{"title":"Association Between Plant-Based Diet and Continuous Glucose Monitoring-Derived Glycemic Dynamics Among Pregnant Women With Gestational Diabetes.","authors":"Meng Ye,Congmei Xiao,Meiqi Shi,Sha Lu,Xinxiu Liang,Zelei Miao,Ke Zhang,Wanglong Gou,Jingnan Chen,Jiali Wang,Xuhong Wang,Sirithon Siriamornpun,Wensheng Hu,Ju-Sheng Zheng,Yuanqing Fu","doi":"10.1002/mnfr.70085","DOIUrl":"https://doi.org/10.1002/mnfr.70085","url":null,"abstract":"We aim to investigate the association of plant-based diets with the continuous glucose monitoring (CGM)-derived glycemic metrics among gestational diabetes mellitus (GDM) patients. We included 1756 GDM patients in the present analyses and assessed plant-based dietary patterns through constructing a plant-based diet index (PDI), healthy PDI (hPDI), and unhealthy PDI (uPDI). CGM-glycemic metrics, such as time in range (TIR), mean blood glucose (MBG), time below range (TBR), low blood glucose index (LBGI), mean of daily differences (MODD), and glycemic risk assessment in diabetes equation (GRADE), were constructed. We found that individuals in the highest quartile of PDI were more likely to have greater TIR (β: 0.28, 95% CI: 0.14 to 0.41) and MBG (β: 0.23, 95% CI: 0.09 to 0.36), while lower TBR (β: -0.26, 95% CI: -0.39 to -0.12), LBGI (β: -0.18, 95% CI: -0.32 to -0.05), and GRADE (β: -0.25, 95% CI: -0.39 to -0.11), compared to those in the lowest quartile. Moreover, most of these associations demonstrated a dose-response relationship, and hPDI and uPDI showed distinct associations with MODD, with higher hPDI favoring a healthier MODD pattern (FDR < 0.05). This study suggests potential benefits of increasing intake of plant-based food for glycemic management among GDM patients.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"8 1","pages":"e70085"},"PeriodicalIF":5.2,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetylcholinesterase Inhibition and Antioxidant Activity of DHA-Disubstituted Phospholipids dha -二取代磷脂对乙酰胆碱酯酶的抑制作用及其抗氧化活性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-13 DOI: 10.1002/mnfr.70095

Ernestina Garcia-Quinto, Sabrina Sollecito-Rovella, Victor M. Amador-Luna, Lidia Montero, Gloria Fernandez-Lorente

引用次数: 0

Quercetin Enhances GLP-1 Secretion via TAS2R38-Mediated PLC Signaling in Enteroendocrine L-Cells. 槲皮素通过tas2r38介导的PLC信号通路促进肠内分泌l细胞GLP-1分泌

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-13 DOI: 10.1002/mnfr.70109

Chenxuan Wang,Jiefang Zhou,Xiaojing Liu,Fengmei Zhu,Jun Li,Wentao Xu,Jinjin Liu

引用次数: 0

Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial. 一项交叉随机对照试验：在健康成年男性中，高脂肪膳食中富含番茄泥可减少餐后血浆和脂肪组织炎症生物标志物

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-12 DOI: 10.1002/mnfr.70115

Lea Sani,Julien Astier,Djaffar Ould-Ali,Patrick Borel,Jean-François Landrier

{"title":"Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial.","authors":"Lea Sani,Julien Astier,Djaffar Ould-Ali,Patrick Borel,Jean-François Landrier","doi":"10.1002/mnfr.70115","DOIUrl":"https://doi.org/10.1002/mnfr.70115","url":null,"abstract":"The postprandial period is marked by increased plasma inflammatory biomarkers and heightened adipose tissue inflammation. Consumption of tomato-based products has been linked to reduced inflammation, potentially lowering the risk of cardiometabolic diseases. This study investigated the addition of tomato puree to a high-fat meal (HFM) on postprandial inflammation in healthy men. Thirty-nine healthy men participated in a randomized crossover trial (NCT02100774). Two meals were given: a HFM and the same HFM with 100 g tomato puree (TPM). Blood samples and adipose tissue biopsies were taken at various timepoints to measure inflammatory markers. TPM reduced plasma tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, and C-C motif chemokine ligand (CCL)-2, and gene expression of TNFA, IL6, IL1B, and CCL5 in adipose tissue. In contrast, HFM increased IL-1β, CCL2, and adipose gene expressions of IL6, IL1B, and CCL2. Variations and net incremental area under the curve (iAUCsnet) between groups showed significantly lower inflammatory markers in TPM, except for plasma CCL2 and CCL5 expression. Incorporating tomato puree in HFM reduces both systemic and adipose tissue inflammation during the postprandial period. These findings suggest that tomato-based products may contribute to the reduction of postprandial inflammation, potentially explaining their cardiometabolic benefits.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"30 1","pages":"e70115"},"PeriodicalIF":5.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model. 黄酮类、槲皮素和表儿茶素对秀丽隐杆线虫病变模型的神经保护作用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-12 DOI: 10.1002/mnfr.70108

Lidia Garzón-García,Begoña Ayuda-Durán,Susana González-Manzano,Celestino Santos-Buelga,Ana M González-Paramás

{"title":"Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model.","authors":"Lidia Garzón-García,Begoña Ayuda-Durán,Susana González-Manzano,Celestino Santos-Buelga,Ana M González-Paramás","doi":"10.1002/mnfr.70108","DOIUrl":"https://doi.org/10.1002/mnfr.70108","url":null,"abstract":"The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the global rise in longevity. The accumulation of amyloid β (Aβ) deposits and hyperphosphorylated Tau protein (p-Tau) are considered the main hallmarks of AD. A growing body of evidence suggests that the regular intake of flavonoid-rich foods could reduce the risk of developing AD or mitigate its progression. This study explores the potential of quercetin (Q) and epicatechin (EC) as effective molecules against AD-like pathology, using the Caenorhabditis elegans BR5270 strain, which expresses the pro-aggregant F3DK280 fragment of the human Tau protein. The results showed that after exposure to 150 µM of EC or Q, worms exhibited increased lifespan, improved chemotaxis, and delayed age-related decline in locomotion. To explore the molecular mechanisms involved, the expression of genes associated with the inhibition of p-Tau proteotoxicity were measured by RT-qPCR. It was found that Q and EC significantly increased the expression levels of autophagy-related genes and of a key gene for de novo synthesis of α- tubulin. EC and Q delay neurodegeneration in the C. elegans tauopathy model, suggesting their potential to reduce the risk of AD progression.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"37 1","pages":"e70108"},"PeriodicalIF":5.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preferential Therapeutic Potential of Ficus carica Against Monosodium Glutamate and Metanil Yellow-Evoked Hepato-Renal Injury: In Vivo and In Silico Approaches. 无花果对味精和甲氧胺黄诱发的肝肾损伤的优先治疗潜力：体内和计算机方法。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-12 DOI: 10.1002/mnfr.70030

Hanaa M Hassan,Ahmed Abdeen,Magda E Mahmoud,Nawal H Almohammadi,Mohamed M Abdel-Daim,Ali H El-Far,Donia E F Zaghamir,Mohamed E Mohamed,Ehab K Ali,Nashwa H Aborayah,Tabinda Hasan,Nourelhuda A Mohammed,Dania Abdelhady,Heba Allah M Elbaghdady,Samah F Ibrahim,Khaled M A Hassanein

{"title":"Preferential Therapeutic Potential of Ficus carica Against Monosodium Glutamate and Metanil Yellow-Evoked Hepato-Renal Injury: In Vivo and In Silico Approaches.","authors":"Hanaa M Hassan,Ahmed Abdeen,Magda E Mahmoud,Nawal H Almohammadi,Mohamed M Abdel-Daim,Ali H El-Far,Donia E F Zaghamir,Mohamed E Mohamed,Ehab K Ali,Nashwa H Aborayah,Tabinda Hasan,Nourelhuda A Mohammed,Dania Abdelhady,Heba Allah M Elbaghdady,Samah F Ibrahim,Khaled M A Hassanein","doi":"10.1002/mnfr.70030","DOIUrl":"https://doi.org/10.1002/mnfr.70030","url":null,"abstract":"Food preservatives can break food safety worldwide; herein, we studied the mitigating effect of Ficus carica (FC) on hepato-renal injury resulting from monosodium glutamate (MSG) or metanil yellow (MY) as a common food preservative. Rats were assigned into five groups; Control, MSG (400 mg/kg), MY (200 mg/kg), FC+MSG (received FC plus MSG), and FC+MY group (received FC plus MY). The antioxidant properties of FC were evaluated. The results revealed the antioxidant potency of FC leave extract. MSG/MY evoked a hepato-renal injury indicated by marked elevations in their biochemical functions. Besides, oxidative damage was also initiated represented by significant increases in MDA levels and decreases in GSH content and SOD activity accompanied by apoptotic cascade (increases in Bax/Bcl2 ratio and caspase3 expression). The molecular docking ascertained the interaction between MSG/MY and cellular antioxidants. However, FC was able to reduce the MSG/MY-induced oxidative stress, apoptosis, and histopathological alterations as well as improve the liver and kidney functions. In the molecular docking model, the natural bioactive compounds of FC explored high affinities for binding with Bax and caspase-3 abrogating the induced apoptosis. The antioxidant potential of FC mitigated the hepato-renal damage in rats caused by MSG or MY.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 1","pages":"e70030"},"PeriodicalIF":5.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0