Molecular Nutrition & Food Research最新文献

Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-26 DOI: 10.1002/mnfr.202400284

Ainá E. Domingos, Cíntia M. da Costa Breves, Luiz F. Boa, Itanna I. A. de Souza, Leonardo Maciel, Fernando A. C. Seara, Rodrigo S. Fortunato, Jose H. M. Nascimento

{"title":"Quercetin Reduces the Susceptibility to Cardiac Reperfusion Arrhythmias in Ovariectomized Rats","authors":"Ainá E. Domingos, Cíntia M. da Costa Breves, Luiz F. Boa, Itanna I. A. de Souza, Leonardo Maciel, Fernando A. C. Seara, Rodrigo S. Fortunato, Jose H. M. Nascimento","doi":"10.1002/mnfr.202400284","DOIUrl":"https://doi.org/10.1002/mnfr.202400284","url":null,"abstract":"Cardiovascular diseases (CVDs) are the leading cause of death globally. Decrease in female sex hormones during menopause increases the risk of cardiovascular disease, mainly ischemic heart disease (IHD). Quercetin, a flavonoid, has beneficial properties in CVDs due to its antioxidant, anti-inflammatory, and anti-apoptotic effects. The aim of this study was to investigate the effects of quercetin on susceptibility to cardiac reperfusion arrhythmias and mitochondrial function in ovariectomized rats (OVX). Three-month-old Wistar female rats were randomly assigned to the following experimental groups: SHAM-operated, vehicle-treated (DMSO 10% + PBS, 1 mL kg−1); OVX (vehicle-treated); and OVX+Q (25 mg·kg−1). The three experimental groups were carried out for 4 weeks (five times a week) by oral gavage. Quercetin treatment effectively decreased myocardial infarct size and susceptibility to reperfusion arrhythmias. Quercetin treatment was also effective in preventing mitochondrial swelling, while increased ATP production compared to the OVX group. In conclusion, our results indicate that quercetin could have a therapeutic effect in preventing some of the pathophysiological changes caused by low estrogen levels in the cardiovascular system.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"10 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fish Oil's Preventive Effect on Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Involvement of NF-ҝB Pathways and Oxidative Stress in a Dose- and Route Dependent Manner

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-26 DOI: 10.1002/mnfr.202400630

Hayeme Cheniti, Assia Kadi, Rym Agred, Yacine Kadi, Meriem Khadidja Djeradi, Hanane Melliti, Nadia Chiheb, Hind Kherfi, Mahfoud Messarah

{"title":"Fish Oil's Preventive Effect on Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Involvement of NF-ҝB Pathways and Oxidative Stress in a Dose- and Route Dependent Manner","authors":"Hayeme Cheniti, Assia Kadi, Rym Agred, Yacine Kadi, Meriem Khadidja Djeradi, Hanane Melliti, Nadia Chiheb, Hind Kherfi, Mahfoud Messarah","doi":"10.1002/mnfr.202400630","DOIUrl":"https://doi.org/10.1002/mnfr.202400630","url":null,"abstract":"This study investigated the chemopreventive mechanisms of fish oil (FO) at different doses and administration routes in skin carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) and croton oil (CO) in Swiss albino mice. Seventy mice were divided into 10 groups, including controls and those receiving FO either orally or topically, with or without the carcinogenesis protocol. Warts were morphologically analyzed. Anatomopathological analysis, qRT-PCR of nuclear factor kappa B (NF-қB) subunits' gene expression, and evaluation of oxidative parameters were conducted. Anatomopathological analysis revealed a presence of invasive squamous cell carcinoma (SCC) in DMBA group. Both oral (500 mg/kg/day) and topical FO treatment showed no signs of cancer, while oral administration at 50 mg/kg/day had no therapeutic effect, and 250 mg/kg/day resulted in low-grade malignancy. Both oral (250 and 500 mg/kg/day) and topical FO significantly reduced NF-кB1 gene expression, alleviated oxidative stress markers, and restored antioxidant enzyme activities compared to the DMBA group. FO shows dose-dependent chemopreventive effects, with oral administration potentially as effective as topical application when using an appropriate dosage. The development of SCC is linked to the stress status and the upregulation of the canonical NF-κB pathway, while FO's chemoprotective effects likely result from its downregulation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"261 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143044594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Probiotic Potential: Physicochemical Approaches to Evaluate Probiotic Bacterial Adhesion Potential to the Intestinal Tract 释放益生菌潜能：评估益生菌粘附肠道潜能的物理化学方法

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-23 DOI: 10.1002/mnfr.202400705

Thị-Thanh-Trúc Phùng, Sébastien Dupont, Laurent Beney, Julie Chanut, Thomas Karbowiak

{"title":"Unlocking Probiotic Potential: Physicochemical Approaches to Evaluate Probiotic Bacterial Adhesion Potential to the Intestinal Tract","authors":"Thị-Thanh-Trúc Phùng, Sébastien Dupont, Laurent Beney, Julie Chanut, Thomas Karbowiak","doi":"10.1002/mnfr.202400705","DOIUrl":"https://doi.org/10.1002/mnfr.202400705","url":null,"abstract":"Bacterial adhesion in the gut is critical to evaluate their effectiveness as probiotics. Understanding the bacterial adhesion within the complex gut environment is challenging. This study explores the adhesion mechanisms and the adhesion potential of five selected bacterial strains (Escherichia coli, Lactiplantibacillus plantarum, Faecalibacterium duncaniae, Bifidobacterium longum, and Bifidobacterium longum subsp. infantis) at the initial stages when bacterial cells arriving in the gut, using different physicochemical approaches. Bacterial morphology, rheology, and surface properties were evaluated. Surprisingly, previous methods such as bacterial adhesion to hydrocarbon and the interfacial tension between bacterial suspensions and mineral oil did not fully capture the bacterial adhesion to intestinal mucus. Consequently, this study introduced a novel approach to assess bacterial adhesion to mucus, based on contact angle measurements, calculation of surface tension, and work of adhesion. Interestingly, both small and large intestinal mucus are rather hydrophilic, and thus highly hydrophilic bacteria such as E. coli and B. infantis tend to adhere better. Additionally, a multicriteria evaluation of bacterial adhesion to the gut, from the bulk liquid transport stage until the irreversible adhesion, was proposed. E. coli and B. infantis demonstrated the highest overall adhesion potential in the intestinal tract, followed by Lpb. plantarum, B. longum, and F. duncaniae, respectively. This work contributed original physicochemical approaches to comprehensively examine bacterial adhesion in the gut.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"20 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent Fasting Ameliorates β-Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model 间歇性禁食改善阿尔茨海默病模型中β-淀粉样蛋白沉积和认知障碍，并伴有小胶质细胞内脂滴聚集减少

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-22 DOI: 10.1002/mnfr.202400660

Liangwei Wu, Yang Zhao, Xiaokang Gong, Zheng Liang, Jing Yu, Jiaquan Wang, Yuheng Zhang, Xiaochuan Wang, Xiji Shu, Jian Bao

{"title":"Intermittent Fasting Ameliorates β-Amyloid Deposition and Cognitive Impairment Accompanied by Decreased Lipid Droplet Aggregation Within Microglia in an Alzheimer's Disease Model","authors":"Liangwei Wu, Yang Zhao, Xiaokang Gong, Zheng Liang, Jing Yu, Jiaquan Wang, Yuheng Zhang, Xiaochuan Wang, Xiji Shu, Jian Bao","doi":"10.1002/mnfr.202400660","DOIUrl":"https://doi.org/10.1002/mnfr.202400660","url":null,"abstract":"Scope: Alzheimer's disease (AD) is the most prevalent form of dementia, lack of effective therapeutic interventions. In this study, we investigate the impact of intermittent fasting (IF), an alternative strategy of calorie restriction, on cognitive functions and AD-like pathology in a transgenic mouse model of AD. Methods and results: APP/PS1 mice at 6 months were randomly allocated to two dietary groups: one receiving ad libitum (AL) feeding and the other undergoing IF for 1 month. Y maze, Barnes maze, western blotting, and immunofluorescence were employed. Behavioral assessments revealed that the APP/PS1-IF group demonstrated notable improvements in cognitive function compared to the AL group. Further analysis showed that microglia in the APP/PS1-IF mice exhibited enhanced phagocytic activity, characterized by prominent enlargement of soma and reduced complexity of their processes. Importantly, IF significantly decreased the accumulation of lipid droplets (LDs) within microglia. These microglia with less LDs may contribute to enhanced β-amyloid (Aβ) phagocytosis, thereby ameliorating Aβ deposition in the brains of APP/PS1-IF mice. Conclusion: Our findings demonstrate that IF ameliorates amyloid deposition and cognitive deficits in the AD model mice, which is associated with the reduction of LDs within microglia, providing support for the use of the dietary intervention against AD pathology.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"1 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review TCF7L2、PPARγ 和 KCNJ11 基因型与口服葡萄糖耐量试验的胰岛素反应之间的关系：系统综述

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-20 DOI: 10.1002/mnfr.202400561

Carmen P. S. Blanken, Sandra Bayer, Sophie Buchner Carro, Hans Hauner, Christina Holzapfel

{"title":"Associations Between TCF7L2, PPARγ, and KCNJ11 Genotypes and Insulin Response to an Oral Glucose Tolerance Test: A Systematic Review","authors":"Carmen P. S. Blanken, Sandra Bayer, Sophie Buchner Carro, Hans Hauner, Christina Holzapfel","doi":"10.1002/mnfr.202400561","DOIUrl":"https://doi.org/10.1002/mnfr.202400561","url":null,"abstract":"Scope: Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype. This systematic review evaluates associations between genotype and insulin response to an oral glucose tolerance test (OGTT) in terms of insulin area under the curve (AUC). Methods and results: Three electronic databases (Web of Science, Embase, PubMed) were searched for studies investigating associations between insulin AUC after an OGTT and single nucleotide polymorphisms (SNPs) belonging to the transcription factor 7 like 2 (TCF7L2) gene, the peroxisome proliferator‐activated receptor gamma (PPARγ) gene, or the potassium inwardly rectifying channel subfamily J member 11 (KCNJ11) gene in persons without diabetes. A total of 5199 articles were identified, of which 38 were included. Among them were family‐based studies (9), twin studies (2), and studies with unrelated participants (27). Seventeen articles investigated TCF7L2 (7 SNPs), 14 investigated PPARγ (1 SNP), and 8 investigated KCNJ11 (5 SNPs). For all investigated SNPs, at least half of the reports indicated no statistically significant association with postprandial insulin AUC. Conclusion: No evidence was found for associations between TCF7L2, PPARγ, and KCNJ11 genotypes and insulin AUC after an OGTT. Future studies should investigate the effect of genetic risk scores on postprandial insulin.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"27 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 2'25 发布信息：Mol. Nutr。Food Res. 2'25

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-19 DOI: 10.1002/mnfr.202570002

引用次数: 0

Citronellal Alleviates Insulin Resistance in High-Fat Diet/Streptozocin Model: Role of Asprosin/Olfactory Receptor Axis 香茅醛减轻高脂肪饮食/链脲佐菌素模型的胰岛素抵抗：阿斯普罗素/嗅觉受体轴的作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-16 DOI: 10.1002/mnfr.202400654

Aya Abdelaziz, Yousra M. El-Far, Noha Abdel-Rahman

{"title":"Citronellal Alleviates Insulin Resistance in High-Fat Diet/Streptozocin Model: Role of Asprosin/Olfactory Receptor Axis","authors":"Aya Abdelaziz, Yousra M. El-Far, Noha Abdel-Rahman","doi":"10.1002/mnfr.202400654","DOIUrl":"https://doi.org/10.1002/mnfr.202400654","url":null,"abstract":"Ectopic olfactory receptors are expressed in nonolfactory tissues and perform diverse roles including regulation of glucose homeostasis. We explored the effect of citronellal treatment on olfactory receptor 4M1 subtype (OR4M1) signaling in insulin resistance and Type II diabetes in rats. We aimed to validate the anti-diabetic effect of citronellal through Asprosin/OR4M1 modulation. Exploring new antidiabetics and pharmacological targets is important to improve quality of life and limit complications. The model was established in Sprague-Dawley rats by a high-fat diet for 4 weeks followed by a single low-dose streptozotocin (STZ) (35 mg/kg/ip). One week after STZ injection, oral citronellal (100 mg/kg) was administered for 4 weeks. Citronellal lowered serum glucose and triglycerides and ameliorated OGTT and HOMA-IR results. Docking results revealed that citronellal blocked the Asprosin binding site at OR4M1. The hepatic expression of OR4M1 and Asprosin was reduced. Citronellal lowered cAMP levels causing attenuated levels of protein kinase A and downstream gluconeogenic enzymes: glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. Citronellal also inhibited the expression of hepatic TLR-4 and inhibited JNK phosphorylation. Citronellal attenuated hepatic levels of NF-κB, p-NF-κB, and downstream proteins MCP-1 and TNF-α. These results suggest that citronellal alleviates insulin resistance by mitigating Asprosin/OR4M1 and Asprosin/TLR4/JNK signaling.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"18 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

U-Shaped Association Between Dietary Copper Intake and New-Onset Chronic Kidney Disease: A 30-Year Follow-Up Study From Young Adulthood to Midlife 膳食铜摄入量与新发慢性肾脏疾病之间的u型关系：一项从青年到中年的30年随访研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-15 DOI: 10.1002/mnfr.202400761

Yiwei Zhang, Xiaoqin Gan, Hao Xiang, Yanjun Zhang, Sisi Yang, Ziliang Ye, Yu Huang, Yiting Wu, Jinsheng Mai, Jianping Jiang, Xianhui Qin, Yuanyuan Zhang

{"title":"U-Shaped Association Between Dietary Copper Intake and New-Onset Chronic Kidney Disease: A 30-Year Follow-Up Study From Young Adulthood to Midlife","authors":"Yiwei Zhang, Xiaoqin Gan, Hao Xiang, Yanjun Zhang, Sisi Yang, Ziliang Ye, Yu Huang, Yiting Wu, Jinsheng Mai, Jianping Jiang, Xianhui Qin, Yuanyuan Zhang","doi":"10.1002/mnfr.202400761","DOIUrl":"https://doi.org/10.1002/mnfr.202400761","url":null,"abstract":"Scope: The relationship of dietary copper intake with new-onset chronic kidney disease (CKD) remained unclear. We aimed to examine the association of dietary copper intake with new-onset CKD in a 30-year follow-up study from young adulthood to midlife. Methods and results: A total of 4038 U.S. adults aged 18–30 years and without reduced estimated glomerular filtration rate (eGFR) from the Coronary Artery Risk Development in Young Adults (CARDIA) study was included. During a 30-year follow-up, 642 (15.9%) participants developed new-onset CKD. Overall, there was a U-shaped relationship between dietary copper intake and new-onset CKD (p for nonlinearity = 0.034). When copper intake was assessed as quartiles, compared with those in the second quartile (2.03–<2.46 mg/day), the adjusted hazard ratios (HRs) (95% confidence interval [CI]) for new-onset CKD were 1.29 (1.05, 1.66), 1.29 (1.02, 1.64), and 1.49 (1.16, 1.91) for participants in the first (<2.03 mg/day), third (2.46–<3.11 mg/day), and fourth (≥3.11 mg/day) quartiles, respectively. Similar U-shaped associations were observed for new-onset eGFR decline and albuminuria. Conclusions: There was a U-shaped relationship of dietary total copper intake with new-onset CKD, with the lowest risk at a dietary copper intake of 2.03–<2.46 mg/day. Emphasizing the importance of maintaining optimal copper intake levels for the primary prevention of CKD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"74 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Healthful Plant-Based Dietary Pattern and Obesity Trajectories and Future Cardiovascular Diseases in Middle-Aged and Elderly: A Prospective and Longitudinal Cohort Study 健康植物性饮食模式与中老年人肥胖轨迹和未来心血管疾病之间的关系：一项前瞻性和纵向队列研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-15 DOI: 10.1002/mnfr.202400833

Zhixing Fan, Chaojun Yang, Chenyu Zhao, Hui Wu, Huibo Wang, Ying Yang, Qi Li, Jian Yang

{"title":"Association Between Healthful Plant-Based Dietary Pattern and Obesity Trajectories and Future Cardiovascular Diseases in Middle-Aged and Elderly: A Prospective and Longitudinal Cohort Study","authors":"Zhixing Fan, Chaojun Yang, Chenyu Zhao, Hui Wu, Huibo Wang, Ying Yang, Qi Li, Jian Yang","doi":"10.1002/mnfr.202400833","DOIUrl":"https://doi.org/10.1002/mnfr.202400833","url":null,"abstract":"We aimed to explore the association between plant-based dietary (PBD) patterns and obesity trajectories in middle-aged and elderly, as well as obesity trajectories linked to cardiovascular disease (CVD) risk. A total of 7108 middle-aged and elderly UK Biobank participants with at least three physical measurements were included. Dietary information collected at enrolment was used to calculate the healthful plant-based diet index (hPDI). Group-based trajectory modeling identified two trajectories for each adiposity measure: BMI Low-Smooth and High-Growth-Decline; FMI Low-Smooth and High-Growth-Decline; WHR Low-Growth and High-Growth. Logistic regression showed that participants in the medium and high hPDI groups were less likely to follow the BMI High-Growth-Decline (OR = 0.72, 95% CI: 0.60–0.87; OR = 0.49, 95% CI: 0.39–0.61), FMI High-Growth-Decline (OR = 0.71, 95% CI: 0.60–0.84; OR = 0.55, 95% CI: 0.46–0.66), and WHR High-Growth (OR = 0.73, 95% CI: 0.61–0.87; OR = 0.52, 95% CI: 0.43–0.63) trajectories. After a median follow-up time of 3.88 years, Cox regression showed higher CVD risk for participants in these trajectories (HR = 1.70, 95% CI: 1.37–2.11; HR = 1.68, 95% CI: 1.37–2.06; HR = 1.30, 95% CI: 1.04–1.63). A healthy PBD pattern was associated with the maintenance of a healthy BMI classification. Furthermore, the long-term stabilization of a healthy BMI classification may be linked to a reduced risk of CVD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"9 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation 香草酸通过菌群和巨噬细胞调节治疗溃疡性结肠炎的潜力

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-01-15 DOI: 10.1002/mnfr.202400785

Hu Zhao, Xingxing Fu, Yaru Wang, Zhao Shang, BangHua Li, Li Zhou, Yue Liu, Dan Liu, Bo Yi

{"title":"Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation","authors":"Hu Zhao, Xingxing Fu, Yaru Wang, Zhao Shang, BangHua Li, Li Zhou, Yue Liu, Dan Liu, Bo Yi","doi":"10.1002/mnfr.202400785","DOIUrl":"https://doi.org/10.1002/mnfr.202400785","url":null,"abstract":"This study investigated the protective effects of the dietary polyphenol vanillic acid (VA) on dextran sulfate sodium-induced acute ulcerative colitis (UC) in mice, focusing on its impact on the gut microbiota and inflammatory responses. VA was supplemented following dextran sulfate sodium administration, and key indicators, including body weight, disease activity index, colon length, spleen index, and inflammatory markers, were assessed. VA supplementation significantly alleviated UC symptoms, preserved intestinal barrier integrity, and reduced pro-inflammatory cytokine levels. Additionally, VA positively altered the gut microbiota composition, promoting beneficial bacteria such as Akkermansia muciniphila while suppressing the arachidonic acid metabolism pathway. Fecal microbiota transplantation confirmed that the VA-modified gut microbiota contributed to these protective effects. VA also facilitated macrophage polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, further mitigating inflammation. These findings highlight the potential of VA as a natural dietary intervention for UC, emphasizing its role in regulating the gut microbiota and inflammatory pathways, which may have significant nutritional relevance in managing inflammatory bowel diseases.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"92 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0