Molecular Nutrition & Food Research最新文献

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis 紫檀芪和白藜芦醇对肝脂肪变性大鼠肝脏代谢组的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-30 DOI: 10.1002/mnfr.70078

Alfredo Fernández-Quintela, Emily P. Laveriano-Santos, Tania Portolés, Andreu Gual-Grau, Juan Vicente Sancho, Maria P. Portillo

{"title":"Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis","authors":"Alfredo Fernández-Quintela, Emily P. Laveriano-Santos, Tania Portolés, Andreu Gual-Grau, Juan Vicente Sancho, Maria P. Portillo","doi":"10.1002/mnfr.70078","DOIUrl":"https://doi.org/10.1002/mnfr.70078","url":null,"abstract":"To gain more light on the effects of resveratrol and pterostilbene in the hepatic metabolic modifications in an in vivo model of diet-induced hepatic steatosis, and to explore their relationships with gut microbiota by untargeted metabolomics and metagenomics. Rats were divided into five groups receiving either a standard diet or a high-fat high-fructose (HFHF) diet supplemented or not with pterostilbene (15 or 30 mg/kg body weight/day; PT15 or PT30 groups, respectively) or resveratrol (30 mg/kg body weight/day; RSV30 group). Supplementation with the stilbenes reduced the hepatic steatosis induced by the HFHF diet. After the metabolomics study, 27 differentially expressed metabolites showed variable importance in projection scores > 1 and could be considered as potential biomarkers. Therefore, based on the pathway enrichment analysis, “riboflavin metabolism” and “nicotinate and nicotinamide metabolism” revealed significant enrichment. Further, riboflavin showed positive correlations to Eubacterium and Faecalibacterium, and negative correlations to Lactobacillus and Oscillospira genera. Nicotinamide mononucleotide was only positively correlated to the Ralstonia genus. The untargeted metabolomics approach showed that the actions of resveratrol or pterostilbene on the prevention of liver steatosis are mediated by specific mechanisms of action. Particularly, pterostilbene, but not resveratrol, is suggested to significantly enrich riboflavin or nicotinate and nicotinamide metabolic pathways.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"30 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PGC-1α Activation by Polyphenols: A Pathway to Thermogenesis 多酚激活PGC-1α：产热途径

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-29 DOI: 10.1002/mnfr.70072

Nicholas Vannuchi, Luciana Pisani

引用次数: 0

Chronic Alcohol Exposure Modulates Atherosclerotic Plaque Vulnerability in ApoE Knockout Mice 慢性酒精暴露调节ApoE敲除小鼠动脉粥样硬化斑块易感性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-29 DOI: 10.1002/mnfr.70021

Yu Fu, Naqash Alam, Yuxin Hua, Huifeng Zhang, Enqi Liu, Weimin Li

{"title":"Chronic Alcohol Exposure Modulates Atherosclerotic Plaque Vulnerability in ApoE Knockout Mice","authors":"Yu Fu, Naqash Alam, Yuxin Hua, Huifeng Zhang, Enqi Liu, Weimin Li","doi":"10.1002/mnfr.70021","DOIUrl":"https://doi.org/10.1002/mnfr.70021","url":null,"abstract":"Aim: This study aimed to examine the effect of chronic alcohol consumption on the development and progression of atherosclerosis in apolipoprotein E-knockout (ApoE−/−) mice. Method: Male ApoE−/− mice, aged 8 weeks, were randomly assigned to four groups: control, model, low-dose alcohol, and high-dose alcohol. The mice were fed a normal chow or high-fat diet for 14 weeks, with water provided alongside 1% (v/v) or 5% (v/v) alcohol solutions. Results: Mice in the 1% (v/v) alcohol group showed a significant increase in subcutaneous and epididymal fat compared to those in the model group. However, basal metabolic markers remained unchanged in the 5% (v/v) alcohol group, although water intake was significantly lower. Histological analyses of the experimental groups exposed to alcohol revealed no protective effects against atherosclerosis in the aortic tree or plaque deposition in the aortic root. Additionally, no significant changes were observed in the macrophages and smooth muscle cells within the aortic root plaques. Nevertheless, low-dose alcohol exposure protected plaque vulnerability compared with the model group, whereas high-dose alcohol had no effect. Transcriptomic analysis of aortic tissue further indicated that alcohol consumption reduced the expression of genes related to lipid transport and metabolic abnormalities.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"43 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a Functional Food Mixture on Patients Undergoing Hemodialysis: Preliminary Results Highlighting the Modulation of Uremic Toxins Derived From Microbiota and Antioxidant Markers 功能性食物混合物对血液透析患者的影响：初步结果强调了微生物群和抗氧化标志物对尿毒症毒素的调节

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-28 DOI: 10.1002/mnfr.70083

Danielle Nascimento, Isadora Britto, Heloiza Couto, Livia Alvarenga, Ludmila F. M. F. Cardozo, Andresa A. Berretta, Marcelo Ribeiro-Alves, Danielle Figueiredo da Cunha, Carolina de Oliveira Ramos Petra de Almeida, Isabela Lemos, Mônica Martins Guimarães Guerra, Maria E. S. Costa, Lia S. Nakao, Anderson J. Teodoro, Denise Mafra

{"title":"Effects of a Functional Food Mixture on Patients Undergoing Hemodialysis: Preliminary Results Highlighting the Modulation of Uremic Toxins Derived From Microbiota and Antioxidant Markers","authors":"Danielle Nascimento, Isadora Britto, Heloiza Couto, Livia Alvarenga, Ludmila F. M. F. Cardozo, Andresa A. Berretta, Marcelo Ribeiro-Alves, Danielle Figueiredo da Cunha, Carolina de Oliveira Ramos Petra de Almeida, Isabela Lemos, Mônica Martins Guimarães Guerra, Maria E. S. Costa, Lia S. Nakao, Anderson J. Teodoro, Denise Mafra","doi":"10.1002/mnfr.70083","DOIUrl":"https://doi.org/10.1002/mnfr.70083","url":null,"abstract":"Combining functional foods may mitigate oxidative stress and gut dysbiosis complications in patients with chronic kidney disease (CKD). This study evaluated the impact of a mixture of turmeric and propolis on redox balance markers and microbiota-derived uremic toxins in patients undergoing hemodialysis (HD). Patients received 10 mL of a compound containing Curcuma longa L. (130 mg curcuminoids/day) and green propolis extract (110 mg/day of green propolis [EPP-AF]), along with ginger and lemon juice, or a placebo, once a day for 8 weeks. Antioxidant capacity was analyzed using the oxygen radical absorption capacity (ORAC) test, iron reduction power (FRAP) test, and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) test. Malondialdehyde (MDA) was determined to estimate lipid peroxidation, and HPLC was used to evaluate uremic toxins. The study involved 35 patients: 17 in the intervention group (51 [19] years; body mass index [BMI], 23.7 [5.4] kg/m2) and 18 in the placebo group (51.5 [12.2] years; BMI, 23.4 [3.8] kg/m2). The intervention with functional foods significantly increased the FRAP test levels compared to the placebo group (p < 0.01), and there was a tendency to reduce indole-3-acetic acid plasma levels. Combining functional foods such as turmeric and propolis extracts can improve CKD patients’ antioxidant capacity.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"18 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications 食用和药用真菌作为候选天然抗抑郁药：机制和营养意义

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-28 DOI: 10.1002/mnfr.70080

Pin Gong, Jiating Wang, Hui Long, Wenjuan Yang, Xuefeng Chen, Nan Li, Fuxin Chen, Jie Zhang, Yuxi Guo

{"title":"Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications","authors":"Pin Gong, Jiating Wang, Hui Long, Wenjuan Yang, Xuefeng Chen, Nan Li, Fuxin Chen, Jie Zhang, Yuxi Guo","doi":"10.1002/mnfr.70080","DOIUrl":"https://doi.org/10.1002/mnfr.70080","url":null,"abstract":"This systematic review examines the antidepressant potential of edible medicinal fungi (EMFs), focusing on their bioactive compounds and mechanisms of action. EMFs modulate neurotransmitter systems, including serotonin (5‐HT) and dopamine (DA), alleviating depressive symptoms. Extracts from EMFs, such as Ganoderma lucidum, Hericium erinaceus, Poria cocos, and Cordyceps militaris, demonstrate significant antidepressant‐like effects in preclinical studies. Their bioactive compounds influence the tryptophan‐kynurenine (KYN) pathway, regulate the hypothalamus‐pituitary‐adrenal (HPA) axis, and reduce neuroinflammation, all of which are linked to stress response and mood regulation. The review also explores the gut‐brain axis, highlighting how EMF‐derived polysaccharides improve gut health by modulating microbiota, potentially mitigating depressive symptoms. Additionally, it discusses the use of EMFs in functional foods and dietary supplements, innovations like 3D food printing for depression‐related issues, and synthetic biology for enhancing compound production. Artificial intelligence is used to model complex mechanisms. However, challenges remain, such as standardization and lack of clinical validation. Future research should address these gaps, emphasizing personalized interventions and advanced technologies for next‐generation antidepressant foods.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"82 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet‐Induced Obese Rats 白藜芦醇防止体重增加，抵消内脏脂肪组织功能障碍，改善饮食诱导的肥胖大鼠下丘脑瘦素敏感性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-28 DOI: 10.1002/mnfr.70075

Maria Ibars‐Serra, Aïda Pascual‐Serrano, Andrea Ardid‐Ruiz, Núria Doladé, Sonia Aguilar‐González, Julieta Cirasino, Begoña Muguerza, Manuel Suárez, Jaap Keijer, Anna Arola‐Arnal, Gerard Aragonès

{"title":"Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet‐Induced Obese Rats","authors":"Maria Ibars‐Serra, Aïda Pascual‐Serrano, Andrea Ardid‐Ruiz, Núria Doladé, Sonia Aguilar‐González, Julieta Cirasino, Begoña Muguerza, Manuel Suárez, Jaap Keijer, Anna Arola‐Arnal, Gerard Aragonès","doi":"10.1002/mnfr.70075","DOIUrl":"https://doi.org/10.1002/mnfr.70075","url":null,"abstract":"In obesity, increased adipocyte size is associated with metabolic complications, while elevated adipocyte numbers are considered a protective mechanism against metabolic disturbances. Adipose tissue dysfunction leads to decreased leptin sensitivity and disrupted energy balance regulation. Resveratrol (RSV), a bioactive compound known for potential health benefits, including obesity‐related disorder prevention, has unclear modulatory effects on adipocyte dysfunction and leptin signaling in established obesity. This study investigated the impact of RSV on adiposity and hypothalamic leptin sensitivity in obesity. Rats were fed a cafeteria diet for 9 weeks and subsequently supplemented with different doses of RSV for 22 days. The 200 mg/kg RSV dose reduced leptin concentrations, body weight gain, and body fat mass in obese animals, while mitigating adipocyte hypertrophy and promoting adipocyte hyperplasia in the retroperitoneal fat depot. RSV also improved hypothalamic leptin sensitivity, shedding light on the molecular mechanisms underlying the benefits of RSV consumption for obesity‐related disorders.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"73 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Roles of Selected microRNAs in Glucose Metabolism as a Candidate Biomarker for Diabetes Mellitus 选定的microrna在葡萄糖代谢中的生物学作用作为糖尿病的候选生物标志物

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-26 DOI: 10.1002/mnfr.70077

Assia Sassi, Muhammad Taher Bin Bakhtiar, Muhammad Muzaffar Ali Khan Khattak, Normah Binti Haron, Mohd Arifin Bin Kaderi, Muhamad Ashraf Bin Rostam, Hanapi Bin Mat Jusoh

{"title":"Biological Roles of Selected microRNAs in Glucose Metabolism as a Candidate Biomarker for Diabetes Mellitus","authors":"Assia Sassi, Muhammad Taher Bin Bakhtiar, Muhammad Muzaffar Ali Khan Khattak, Normah Binti Haron, Mohd Arifin Bin Kaderi, Muhamad Ashraf Bin Rostam, Hanapi Bin Mat Jusoh","doi":"10.1002/mnfr.70077","DOIUrl":"https://doi.org/10.1002/mnfr.70077","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a medical disorder characterized by high blood sugar levels resulting from a lack of insulin caused by impaired activity of 𝛽‐cells and/or the inability of insulin to efficiently transport glucose from the bloodstream into cells, a condition referred to as insulin resistance. This occurs not only in insulin‐sensitive tissues such as muscles, adipose tissue, and the liver, but also in the gastrointestinal tract, which may be caused by a defect in the insulin signaling pathway. MicroRNAs (miRNAs) are RNA molecules that do not code for proteins and play a role in multiple pathways. Several studies have suggested that specific miRNAs could potentially be used as biomarkers for diagnosing diabetes. These miRNAs regulate the formation of pancreatic islets, the differentiation of β‐cells, the secretion of insulin, and the control of glucose metabolism. miRNA‐mediated pathways are associated with human genetic illnesses resulting from mutations in the maturation process of miRNAs. The changes in miRNAs impact their ability to bind to mRNA targets, hence modifying gene expression. This review provides a concise overview of the latest studies investigating the correlation between miRNA expression and the regulation of glucose levels in cases of β‐cell malfunction and insulin resistance.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"35 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiomics Reveal the Effects and Regulatory Mechanism of Naringin on Metabolic Dysfunction‐Associated Fatty Liver Disease of Laying Hens 多组学揭示柚皮苷对蛋鸡代谢功能障碍相关性脂肪肝的影响及调控机制

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-26 DOI: 10.1002/mnfr.70082

Yi Chu, Na Chen, Yuting Liu, Lianghong Zhou, Jinghui Zhang, Jingwu Zhao, Yaxiang Zhao, Zhe Li, Su Yang, Xiaodong Chen

{"title":"Multiomics Reveal the Effects and Regulatory Mechanism of Naringin on Metabolic Dysfunction‐Associated Fatty Liver Disease of Laying Hens","authors":"Yi Chu, Na Chen, Yuting Liu, Lianghong Zhou, Jinghui Zhang, Jingwu Zhao, Yaxiang Zhao, Zhe Li, Su Yang, Xiaodong Chen","doi":"10.1002/mnfr.70082","DOIUrl":"https://doi.org/10.1002/mnfr.70082","url":null,"abstract":"This study aimed to utilize aged laying hens as a model to investigate the effects of naringin on the occurrence and progression of metabolic dysfunction‐associated fatty liver disease (MAFLD), along with its underlying regulatory mechanisms. A total of 288 aged laying hens, 50‐week‐old, were divided into four groups: a normal diet (ND) group, and three naringin groups receiving 200 mg/kg (N1), 400 mg/kg (N2), and 600 mg/kg (N3). The experiment lasted for 10 weeks, after which serum, liver, and cecal contents were collected from the hens. Results indicated that dietary naringin supplementation reduced hepatic lipid deposition, lowered blood lipid levels, improved antioxidant capacity, and promoted estradiol secretion. Additionally, 16S rDNA analysis revealed that naringin enhanced microbial diversity in the cecum and regulated the abundance of gut microbes associated with fatty liver. Untargeted metabolomics of blood demonstrated that naringin decreased the concentration of glycerophospholipid and sterol lipid metabolites while increasing levels of pantothenic acids and amino acid metabolites. Furthermore, liver transcriptome analysis indicated that naringin interfered with fatty acid synthesis and transport processes while enhancing fatty acid oxidation. Dietary naringin supplementation can mitigate the occurrence of MAFLD by regulating the gut–liver axis and estrogen signaling, particularly in postmenopausal women.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"78 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the Chilean Bean Landrace Peumo on Metabolic Syndrome‐Related Parameters in C57BL/6 Mice Fed With a High‐Fat Diet 智利土豆豆Peumo对饲喂高脂饮食的C57BL/6小鼠代谢综合征相关参数的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-26 DOI: 10.1002/mnfr.70089

Felipe Avila, Daniel Droguett, Cristina Theoduloz, Guillermo Schmeda‐Hirschmann

{"title":"Effect of the Chilean Bean Landrace Peumo on Metabolic Syndrome‐Related Parameters in C57BL/6 Mice Fed With a High‐Fat Diet","authors":"Felipe Avila, Daniel Droguett, Cristina Theoduloz, Guillermo Schmeda‐Hirschmann","doi":"10.1002/mnfr.70089","DOIUrl":"https://doi.org/10.1002/mnfr.70089","url":null,"abstract":"Scope: We report a nutritional intervention involving supplementation with boiled beans and secondary metabolites‐enriched extracts (SMEEs) from a Chilean Phaseolus vulgaris landrace in mice with induced metabolic syndrome (MS).Methods and results: The effects of supplementation were assessed in C57BL6 mice with MS induced by a high‐fat diet. Boiled beans (75 and 150 mg animal day−1) and the SMEE (0.8 and 8 mg animal day−1) were administered daily for 4 months. Weight and glycemia were measured weekly. At the end of the experiment, glycemia, total, high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) cholesterol, triglycerides, protein carbonyls, and carboxymethyl lysine (CML) levels were determined in plasma. Oral intake of the SMEE decreased glycemia at the end of the intervention. No statistically significant difference in glycemia was found for the boiled beans compared with controls. The SMEE at 0.8 mg animal day−1 decreased the total amount of CML, mainly in proteins with molecular masses >75 kDa, in agreement with the results for carbonylated proteins.Conclusion: The SMEE of Peumo beans reduces glycemia at the end of the intervention and decreases total CML in plasma, suggesting a potential beneficial effect of bean intake. The results obtained in the intervention encourage further studies in Chilean bean landraces.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"4 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-Demethyl-Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High-Fat Diet-Fed Mice 5-去甲基多甲氧基黄酮通过减少脂肪组织炎症、促进褐变和调节高脂肪饮食喂养小鼠的肠道微生物群来减轻肥胖

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-25 DOI: 10.1002/mnfr.70069

Wei-Sheng Lin, Yu-Lu Lin, Yen-Chun Koh, Pin-Yu Ho, Yu-Cheng Lin, Chi-Tang Ho, Min-Hsiung Pan

{"title":"5-Demethyl-Polymethoxyflavones Mitigate Obesity by Reducing Adipose Tissue Inflammation, Promoting Browning, and Modulating Gut Microbiota in High-Fat Diet-Fed Mice","authors":"Wei-Sheng Lin, Yu-Lu Lin, Yen-Chun Koh, Pin-Yu Ho, Yu-Cheng Lin, Chi-Tang Ho, Min-Hsiung Pan","doi":"10.1002/mnfr.70069","DOIUrl":"https://doi.org/10.1002/mnfr.70069","url":null,"abstract":"Given the escalating prevalence of obesity worldwide, identifying efficacious dietary components is crucial. This study investigated whether citrus-derived 5-demethyl-polymethoxyflavones (5-DPMFs) protect against obesity in high-fat diet (HFD)-induced obese mice. Male C57BL/6 mice were fed an HFD and supplemented with a citrus-derived powder (CP) containing 5-DPMFs as the main bioactive components. Two doses of CP (0.25% and 1% in the diet) were tested, corresponding to approximately 36 and 145 mg/kg body weight of 5-DPMFs, respectively. Key adipose tissue parameters were assessed, including inflammatory cytokines and browning markers associated with p38 MAPK signaling. Treatment with 5-DPMFs significantly attenuated adipose tissue inflammation, as evidenced by reduced levels of MCP-1, TNF-α, IL-6, and IL-1β. Concurrently, fat browning was enhanced by upregulating thermogenic and mitochondrial proteins. Gut microbiota analysis revealed that 5-DPMFs increased the relative abundance of beneficial probiotic species, such as Lactobacillus and Limosilactobacillus reuteri, which have been linked to improved metabolic profiles. These findings demonstrate that 5-DPMFs mitigate obesity-associated adipose inflammation, promote the browning of white adipose tissue (WAT), and favorably regulate gut microbiota composition in HFD-fed mice. Our results suggest that 5-DPMFs could serve as a functional food ingredient for obesity prevention and management.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"6 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0