Molecular Nutrition & Food Research最新文献

Effects of a Plant-Derived Protein Diet Supplemented With Multi-Strain Probiotics on Muscle Mass, Muscle Strength, and Gut Microbiota in Aged Rats. 植物源性蛋白质日粮中添加多菌种益生菌对老年大鼠肌肉质量、肌肉力量和肠道微生物群的影响

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70481

Dengfeng Xu, Qihan Xu, Jiarui Lu, Yamin Chen, Bingmeng Fu, Xue Zhang, Xuefeng Qu, Yangjunna Zhang, Jingjin Hu, Shuguang Fang, Yin Wang

引用次数: 0

Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals. 使用代谢分型识别摄取高脂肪食物后具有不同甘油三酯反应曲线的个体。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70482

Jiaying Hu, Matteo D'Alessandro, Patrik Hansson, Kirsten B Holven, Magne Thoresen, Stine Marie Ulven

{"title":"Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals.","authors":"Jiaying Hu, Matteo D'Alessandro, Patrik Hansson, Kirsten B Holven, Magne Thoresen, Stine Marie Ulven","doi":"10.1002/mnfr.70482","DOIUrl":"10.1002/mnfr.70482","url":null,"abstract":"We observed previously a large variation in individual triglyceride response in a randomized cross-over study with four high-fat meals. The aim of the current study was to identify different groups of triglyceride responders and define their biological profiles. Forty seven healthy adults aged 22-62 years with BMI 18.6-33.9 kg/m2 were included for analysis. A latent class mixed model was applied for clustering. This method identifies subgroups by modelling both the trajectory over time and the effect of different meals, while allowing for individual variability. Four different clusters were identified. Since one cluster contained only two subjects, we continued with three clusters (n = 45). Cluster 1 (n = 18) displayed low postprandial triglyceride response, Cluster 2 (n = 21) had the peak at 2 h and returned to baseline at 6 h, and Cluster 3 (n = 6) had a continuous high triglyceride level after 2 h. Significant differences (p < 0.05) between the clusters were found for sex, fat mass, fat mass percentage, and baseline GlycA level. Through an unsupervised clustering method, this work revealed subgroups in a population based on postprandial triglyceride changes. This approach holds a potential for stratifying individuals by dynamic metabolic responses and detecting metabolically dysfunctional phenotypes.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70482"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between. 酚类化合物：从传统用途到创新应用以及介于两者之间的一切。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70478

Marcela de Sá Barreto da Cunha,Cristina Maria Turim Santos Miguel,Emília Maria França Lima,Uelinton Manoel Pinto,Cláudia Vieira Prudêncio,Svetoslav Dimitrov Todorov

{"title":"Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between.","authors":"Marcela de Sá Barreto da Cunha,Cristina Maria Turim Santos Miguel,Emília Maria França Lima,Uelinton Manoel Pinto,Cláudia Vieira Prudêncio,Svetoslav Dimitrov Todorov","doi":"10.1002/mnfr.70478","DOIUrl":"https://doi.org/10.1002/mnfr.70478","url":null,"abstract":"Phenolic compounds are a versatile class of bioactive molecules with growing applications in different areas, including the food and health sectors. This comprehensive review deals with many aspects related to the study of phenolic compounds, starting with advances in extraction, detection, and quantification methods, going through bioavailability, bioactivity, and beneficial health properties, and discussing antioxidant and antimicrobial uses and mechanisms. The work also discusses strategies related to sustainable use and production with opportunities related to the bioeconomy. Industrial applications include food conservation, active packaging systems, functional foods, nutraceuticals, cosmetics, and pharmaceuticals. Relevant mechanisms of action include destabilization of cellular membranes, enzymatic inhibition, oxidative stress induction, and interference on quorum sensing communication systems, with the potential to be used in anti-virulence approaches. The potential use of phenolic compounds against planktonic and sessile bacterial cells (biofilms) is discussed, as well as their synergistic interactions with antibiotics and bacteriocins, aligned with hurdle technology in the food industry. Phenolic compounds are promising sustainable and innovative alternatives in the food, health, and industrial realms.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"72 1","pages":"e70478"},"PeriodicalIF":5.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Investigation of the Crystallization and Thermal Behavior of Animal Fat Mixtures Using a Multi-Technique Approach. 动物脂肪混合物结晶和热行为的多技术实验研究。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70485

Michele Lessona, Antoine Cros, Laurent Sagalowicz, Cynthia Marmet, Antonio Buffo, Elena Simone

{"title":"Experimental Investigation of the Crystallization and Thermal Behavior of Animal Fat Mixtures Using a Multi-Technique Approach.","authors":"Michele Lessona, Antoine Cros, Laurent Sagalowicz, Cynthia Marmet, Antonio Buffo, Elena Simone","doi":"10.1002/mnfr.70485","DOIUrl":"https://doi.org/10.1002/mnfr.70485","url":null,"abstract":"Fats are essential ingredients widely used in the food industry, as well as in cosmetic and pharmaceutical formulations. Solid fats are complex multicomponent systems primarily composed of triacylglycerols (TAGs), which determine the types and properties of the crystalline structures formed. TAGs crystallize in different polymorphs and stacking configurations, with distinct thermal and mechanical properties that influence the macroscopic structure and sensory profile of fat-based products. In this study, a comprehensive multi-technique analysis of animal-derived fats, specifically chicken and beef fats, was conducted. Chemical characterization was performed and solid fat content (SFC) was determined. Thermal behaviour was investigated using differential scanning calorimetry (DSC), whereas crystallization experiments were conducted using in situ turbidity measurements and synchrotron small-angle and wide-angle x-ray scattering (SAXS/WAXS) for structural characterization. Three different synchrotron experimental setups were used for crystallization experiments, including static and sheared conditions. The results demonstrate that the crystallization behaviour of beef and chicken fat samples closely correlate with their TAGs composition. Synchrotron x-ray scattering provided structural insights, highlighting how the polymorphic behaviour is influenced by fat origin and crystallization conditions. For both animal fat types, all three main polymorphs and possible transitions were detected. Moreover, the presence of shear promoted crystallization of stable polymorphs.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70485"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment the Effects of Roasted and Non-Roasted Coffee Extracts on Colon Cancer Cells. 评估烘焙和非烘焙咖啡提取物对结肠癌细胞的影响。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70486

M Šemeláková, P Bober, M Várady, T Hudáková, P Harvanik, J Šalagovič, P Popelka, P Solár

{"title":"Assessment the Effects of Roasted and Non-Roasted Coffee Extracts on Colon Cancer Cells.","authors":"M Šemeláková, P Bober, M Várady, T Hudáková, P Harvanik, J Šalagovič, P Popelka, P Solár","doi":"10.1002/mnfr.70486","DOIUrl":"https://doi.org/10.1002/mnfr.70486","url":null,"abstract":"Coffee extracts contain numerous bioactive compounds. Given the dietary link between coffee consumption and colorectal cancer, this study compared the effects of roasted and green (unroasted) coffee extracts on human colorectal cancer cells (HCT116) and non-cancerous fibroblasts (BJ-5ta) to evaluate how processing influences proliferation and molecular signaling. Real-time cell analysis (RTCA), qRT-PCR, and label-free quantitative proteomic analysis were performed to assess cellular responses. MTS and RTCA showed that in BJ-5Ta fibroblasts, coffee extracts increased proliferation in the order CNR < CAR < CAU < CNU, whereas the trend was reversed in HCT116 cancer cells. Proteomic analysis revealed that in BJ-5Ta cells, unroasted coffee extract caused downregulation of the ribosome pathway, and natural coffee extract caused downregulation of the gap junction pathway, indicating reduced protein synthesis and cell-cell communication as a potential stress-adaptive response. In contrast, in HCT116 cells, unroasted coffee extract upregulated the ribosome pathway. Also, natural coffee extract upregulated the pentose phosphate pathway in HCT116 cells, which may enhance NADPH production and reduce oxidative stress. Current evidence suggests coffee's bioactive compounds may have different effects varying by coffee extract type and their preparation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70486"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olive-Derived Extracts and Bioactive Compounds for Pain Management in Osteoarthritis and Degenerative Knee Pain: A Systematic Review and Meta-Analysis. 橄榄提取物和生物活性化合物对骨关节炎和退行性膝关节疼痛的疼痛管理：系统回顾和荟萃分析。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70490

Desirée Victoria-Montesinos, Pablo Barcina-Pérez, Ana María García-Muñoz

{"title":"Olive-Derived Extracts and Bioactive Compounds for Pain Management in Osteoarthritis and Degenerative Knee Pain: A Systematic Review and Meta-Analysis.","authors":"Desirée Victoria-Montesinos, Pablo Barcina-Pérez, Ana María García-Muñoz","doi":"10.1002/mnfr.70490","DOIUrl":"https://doi.org/10.1002/mnfr.70490","url":null,"abstract":"This study aimed to evaluate the effects of olive-derived extracts and bioactive compounds on pain outcomes and, secondarily, to summarize their reported effects on physical function and related outcomes in adults with osteoarthritis (OA) or degenerative knee/joint pain. A systematic search was conducted in PubMed/MEDLINE, Web of Science, Scopus, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials and other human intervention studies evaluating orally and/or topically administered olive-derived extracts or isolated olive bioactive compounds in individuals with OA or chronic degenerative knee/joint pain were included. The search identified 666 records; after screening, 6 studies met the eligibility criteria, and 3 randomized controlled trials were included in the meta-analysis. Most studies reported reductions in pain following supplementation with olive-derived extracts or isolated bioactive compounds. Meta-analysis suggested a modest reduction in pain compared with control conditions (standardized mean difference = 0.40, 95% CI 0.06-0.75), although this estimate should be interpreted cautiously given the small number of pooled trials and the heterogeneity across interventions. Evidence regarding physical function was more heterogeneous and was therefore synthesized narratively. These findings suggest that olive-derived bioactive compounds may contribute to modest pain reduction, although the available evidence remains limited and preliminary.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70490"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential. 没食子酸不断发展的治疗前景：机制见解和临床潜力的综述。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70491

Woo Hyun Park

{"title":"The Evolving Therapeutic Landscape of Gallic Acid: A Review of Mechanistic Insights and Clinical Potential.","authors":"Woo Hyun Park","doi":"10.1002/mnfr.70491","DOIUrl":"https://doi.org/10.1002/mnfr.70491","url":null,"abstract":"Gallic acid (GA), a plant-derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's \"redox duality\"-its capacity to act as either a radical scavenger or a pro-oxidant. In metabolic disorders, GA reprograms cellular machinery by modulating the miR-709/Nrf2 axis, enhancing LDL clearance via LDLR/PCSK9, and targeting the incretin system. In oncology, GA exhibits context-dependent toxicity, acting as a selective pro-oxidant to induce apoptosis and synergizing with tyrosine kinase inhibitors (TKIs), though safety interactions require careful assessment. GA's expanded neuropharmacological profile includes mitigating ferroptosis via GPX4 rescue and acting as a positive allosteric modulator of Kv1.1 channels. It also potently inhibits the NLRP3 inflammasome in gouty arthritis. Beyond traditional pharmacology, recent studies highlight GA's emergence in material science, including the development of GA-based Metal-Organic Frameworks (MOFs) and functional hydrogels for osteoarthritis, kidney stone prevention, and wound healing. Despite broad bioactivity, poor bioavailability remains a significant challenge, necessitating innovative bioactive material design and rigorous clinical validation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70491"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress in the Application of Lactic Acid Bacteria in Alcoholic Liver Disease. 乳酸菌在酒精性肝病中的应用研究进展

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70489

Longxuan Huo, Yanhong Wang, Ru Zhai, Quan Ji, Chen Qiao, Fan Yang, Fuqi Li, Lin Pan

{"title":"Research Progress in the Application of Lactic Acid Bacteria in Alcoholic Liver Disease.","authors":"Longxuan Huo, Yanhong Wang, Ru Zhai, Quan Ji, Chen Qiao, Fan Yang, Fuqi Li, Lin Pan","doi":"10.1002/mnfr.70489","DOIUrl":"https://doi.org/10.1002/mnfr.70489","url":null,"abstract":"Lactic acid bacteria (LAB) are the main probiotic microorganisms in the human gastrointestinal tract, and their safety in food is recognized globally. Exploring the mechanisms by which LAB mitigate liver injury is crucial for their appropriate application. Alcoholic liver disease (ALD) can be alleviated by improving intestinal epithelial barrier function, controlling lipid metabolism, downregulating inflammatory mediators, and reducing oxidative stress. These mechanisms play important roles in the positive effects of LAB in alleviating liver injury, providing a systematic theoretical basis and practical basis for the clinical application of these bacteria. Future research should focus on transitioning LAB-based interventions for ALD from mechanistic exploration to precision applications. This transition will require a concerted effort in screening functional strains with well-defined molecular targets, developing characterized postbiotic formulations, and rationally designing synergistic symbiotic systems. Nevertheless, the strain-specific effects, potential safety concerns in advanced liver disease, and the need for validation in large-scale, endpoint-driven clinical trials remain significant challenges. To address these challenges, the application of intelligent delivery platforms and multidisciplinary strategies will be critical to achieving the ultimate goal of efficient translation into clinical-grade functional foods.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 9","pages":"e70489"},"PeriodicalIF":4.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Density Lipoprotein-Specific Phospholipid Efflux (HDL-SPE) Assay in Mice. 小鼠高密度脂蛋白特异性磷脂外排（HDL-SPE）测定。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70492

Masaki Sato, Edward B Neufeld, Masato Hamasaki, Alan T Remaley, Kazuhiko Kotani

引用次数: 0

Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study. 母体时间营养和胎盘DNA甲基化：BiSC研究。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-05-01 DOI: 10.1002/mnfr.70465

Joana Llauradó-Pont,Sofia Aguilar-Lacasaña,Marta Cosin-Tomas,Jordi Julvez,Oren Contreras-Rodríguez,Manolis Kogevinas,Kyriaki Papantoniou,Elisa Gallo,Barbara N Harding,Martine Vrijheid,Payam Dadvand,Mariona Bustamante,Camille Lassale

{"title":"Maternal Chrono-Nutrition and Placental DNA Methylation: The BiSC Study.","authors":"Joana Llauradó-Pont,Sofia Aguilar-Lacasaña,Marta Cosin-Tomas,Jordi Julvez,Oren Contreras-Rodríguez,Manolis Kogevinas,Kyriaki Papantoniou,Elisa Gallo,Barbara N Harding,Martine Vrijheid,Payam Dadvand,Mariona Bustamante,Camille Lassale","doi":"10.1002/mnfr.70465","DOIUrl":"https://doi.org/10.1002/mnfr.70465","url":null,"abstract":"The impact of diet during pregnancy on birth outcomes and child health is well established, and epigenetic changes may be one mechanism underlying such associations, but the role of meal timing (chrono-nutrition) is unclear. We conducted an epigenome-wide association study (EWAS) of maternal meal timing and placental DNAm (plaDNAm). Data came from 389 pregnant women in the Barcelona Life Study Cohort (BiSC). Chrono-nutrition and dietary data were collected at 20 weeks of pregnancy, and plaDNAm at delivery was characterized using the Illumina EPIC array. Linear robust regression models tested associations between five chrono-nutritional behaviors (time of first and last meal, nighttime fasting duration, number of eating occasions, and eating jetlag) and plaDNAm. We identified 7 CpGs significantly associated with time of last meal (Bonferroni p < 1E-08) and 63 suggestive CpGs (p < 1E-05). Hits included cg13147785 (E2F8), linked to placental cell cycle regulation, cg17665505 (DAP) and cg18303215 (ABCG5), associated with smoking and lung diseases in adults. To conclude, maternal chrono-nutrition was associated with some CpGs in the placenta, particularly time of last meal. Further studies are needed to clarify how meal timing may influence fetal development and long-term health through epigenetic mechanisms.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"21 1","pages":"e70465"},"PeriodicalIF":5.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147755006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0