Molecular Nutrition & Food Research最新文献

筛选
英文 中文
Preventive Effect of Upland Pigmented Potatoes Against LPS-Induced Inflammation in THP-1 Macrophages 陆地色素马铃薯对lps诱导的THP-1巨噬细胞炎症的预防作用
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-25 DOI: 10.1002/mnfr.70073
Marta Toccaceli, Alessandra Marinelli, Federico Ballabio, Laura Bassolino, Roberto Lo Scalzo, Bruno Parisi, Daniela Pacifico, Federica Nicoletti, Carlo Camilloni, Giuseppe Mandolino, Katia Petroni
{"title":"Preventive Effect of Upland Pigmented Potatoes Against LPS-Induced Inflammation in THP-1 Macrophages","authors":"Marta Toccaceli, Alessandra Marinelli, Federico Ballabio, Laura Bassolino, Roberto Lo Scalzo, Bruno Parisi, Daniela Pacifico, Federica Nicoletti, Carlo Camilloni, Giuseppe Mandolino, Katia Petroni","doi":"10.1002/mnfr.70073","DOIUrl":"https://doi.org/10.1002/mnfr.70073","url":null,"abstract":"Aim of this study was to compare the in vitro anti-inflammatory activity of three commercial potato varieties cultivated upland, Kennebec, Desirée, and Bleuet, whose extracts, based on chemical analyses, were considered chlorogenic acid (CGA)-, carotenoid-, and anthocyanin-rich, respectively. To this aim, THP-1-derived macrophages were pretreated with extracts and then challenged with LPS. While at supraphysiological doses (50 µM), all three extracts significantly counteracted LPS-induced TNF-α, IL-1β, and IL-6, at more physiologically relevant doses (1–5 µM), only Desirée and Bleuet showed anti-inflammatory activity. We hypothesized that the high CGA content in Bleuet extract might interfere with anthocyanins. Supporting this, adding CGA to pure pelargonidin 3-glucoside and peonidin 3-glucoside reduced their anti-inflammatory activity. Similarly, the isolated anthocyanin fraction from Bleuet (ACN fraction) exhibited stronger anti-inflammatory effects than the whole Bleuet extract, and the addition of CGA to the ACN fraction significantly reduced its anti-inflammatory effect. Molecular docking simulations suggested that glucose transporters GLUT-1, GLUT-3, and SGLT-1 could be involved in this antagonist-like interaction. In conclusion, extracts from pigmented varieties Desirée and Bleuet counteracted LPS-induced inflammation in THP-1 macrophages at plasma-relevant doses. Furthermore, CGA could compete with anthocyanins for glucose transporters, limiting their cellular uptake and, consequently, their anti-inflammatory activity.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"26 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143872544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valorization of Prunus cerasus var. Marasca Pomace Derived From Industrial Processing: Recovery, Characterization, and Bioactivity Assessment of Secondary Metabolites 从工业加工中提取的樱桃果渣的价值:次生代谢产物的回收、特性和生物活性评价
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-24 DOI: 10.1002/mnfr.70087
Daniela Bulgari, Luca Pisoni, Stefano Renzetti, Emanuela Gobbi, Noemi Bertoli, Giorgio Gargari, Gokhan Zengin, Gregorio Peron
{"title":"Valorization of Prunus cerasus var. Marasca Pomace Derived From Industrial Processing: Recovery, Characterization, and Bioactivity Assessment of Secondary Metabolites","authors":"Daniela Bulgari, Luca Pisoni, Stefano Renzetti, Emanuela Gobbi, Noemi Bertoli, Giorgio Gargari, Gokhan Zengin, Gregorio Peron","doi":"10.1002/mnfr.70087","DOIUrl":"https://doi.org/10.1002/mnfr.70087","url":null,"abstract":"The phytochemical composition of <i>Prunus cerasus</i> var. marasca pomace produced as industrial byproduct was investigated. Its antioxidant and anti-tyrosinase properties were also assessed to evaluate a possible reuse as a bioactive food ingredient. Secondary metabolites were extracted from pomace using an optimized ultrasound-assisted maceration in ethanol/water. Total phenols (26.2 mg GAE/g), flavonoids (2.5 mg RE/g), and anthocyanins (82.5 µg CE/g) in the extract were determined spectrophotometrically. Seventy metabolites were identified by UHPLC-QToF-MS, and several are here reported in marasca cherries for the first time. The extract exerts valuable free-radical scavenging, metal-reducing, and metal-chelating activities that underlie its antioxidant properties. Also, it inhibits tyrosinase with an effect equaling 39 mg kojic acid/g of extract. However, temperatures &gt;4°C during 6-month storage significantly affected the phenolic content and bioactivity of extract. Pomace of <i>P. cerasus</i> var. marasca cherries can be reused as a source of bioactive secondary metabolites, which can be easily recovered by sustainable ultrasound-assisted maceration. The extract can potentially be used as an additive to increase the oxidative stability of food products and control enzymatic browning, and improve their nutraceutical properties. However, storage time and temperature should be carefully evaluated in order to preserve extract's properties. Alternatively, appropriate stabilization strategies need to be developed further.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats 胎盘和脐带血DNA甲基化变化与边缘人群妊娠期糖尿病相关:饱和脂肪的未知作用
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-24 DOI: 10.1002/mnfr.70058
Fatima Ahmad, Sidra Aftab Uzair, Arun P. Lakshmanan, Shaikha Alabduljabbar, Salma H. Ahmed, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Rose McGready, François Nosten, Damien Chaussabel, Souhaila Al Khodor, Annalisa Terranegra
{"title":"Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats","authors":"Fatima Ahmad, Sidra Aftab Uzair, Arun P. Lakshmanan, Shaikha Alabduljabbar, Salma H. Ahmed, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Rose McGready, François Nosten, Damien Chaussabel, Souhaila Al Khodor, Annalisa Terranegra","doi":"10.1002/mnfr.70058","DOIUrl":"https://doi.org/10.1002/mnfr.70058","url":null,"abstract":"The role of DNA methylation (DNAm) and its modulation by dietary factors in gestational diabetes mellitus (GDM) remains underexplored, particularly in marginalized populations. This study investigates DNAm alterations in GDM-exposed cord blood and placenta and their association with maternal dietary quality and single nutrient intake in a low-income population from the Myanmar–Thailand border. A matched case–control design (GDM: <i>n</i> = 38, controls: <i>n</i> = 34) was selected from a Myanmar–Thailand pregnancy cohort. Dietary intake was assessed via 24-h recalls and analyzed using Nutritionist Pro, with dietary quality evaluated by the healthy eating index (HEI). DNAm was profiled in 72 cord blood and 72 placental samples using the Infinium MethylationEPIC array. Significant differences in dietary vitamin D, total folate, and saturated fat intake were observed between the groups. RnBeads analyses revealed hypomethylation as the predominant DNAm pattern in GDM, particularly at ADORA2B (placenta) and ZFP57 (cord blood) promoters. The excessive intake of saturated fats was associated with GDM hypomethylation profiles and negatively correlated with ZFP57 methylation levels. This study highlights the influence of saturated fat intake on epigenetic changes in pregnancy, revealing potential biomarkers for GDM and emphasizing the need for tailored, population-specific nutritional interventions to mitigate transgenerational health impacts.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"3 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: Mol. Nutr. Food Res. 8'25 发布信息:Mol. Nutr。Food Res. 8分25秒
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-24 DOI: 10.1002/mnfr.70064
{"title":"Issue Information: Mol. Nutr. Food Res. 8'25","authors":"","doi":"10.1002/mnfr.70064","DOIUrl":"10.1002/mnfr.70064","url":null,"abstract":"","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143866768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At-Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers 马黛茶(巴拉圭冬青)茶可能对健康和高危人群的心脏代谢有益:一项在非习惯性消费者中进行的随机、对照、盲、交叉试验
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-22 DOI: 10.1002/mnfr.70065
Laura Bravo, Sara Martínez-López, Jose Luis Sierra-Cinos, Raquel Mateos, Beatriz Sarriá
{"title":"Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At-Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers","authors":"Laura Bravo, Sara Martínez-López, Jose Luis Sierra-Cinos, Raquel Mateos, Beatriz Sarriá","doi":"10.1002/mnfr.70065","DOIUrl":"https://doi.org/10.1002/mnfr.70065","url":null,"abstract":"Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts of mate by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects of moderate intake of yerba mate by nonhabitual consumers. A randomized, crossover, controlled study was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, blood lipids, glucose metabolism, inflammatory cytokines, chemokines, and different markers of endothelial function, as well as incretins, adipocytokines, and different hormones were measured at baseline and after 8 weeks consuming yerba mate or a decaffeinated isotonic drink (control). After daily consumption of three servings of mate tea, blood pressure, inflammatory cytokines, chemokines, and colony-stimulating factors decreased in all participants. LDL-C decreased in normocholesterolemic individuals, while the mate and control interventions elicited similar hypolipidemic action in the hypercholesterolemic group. Ghrelin and glucose-dependent insulinotropic polypeptide (GIP) significantly decreased after mate intake, while glucagon-like peptide 1 (GLP-1) and adipocytokines remained unchanged. Body fat percentage and tricipital skinfold decreased only in healthy subjects, with no effects on total body weight. In conclusion, yerba mate could exert cardiometabolic protective effects in healthy consumers and in subjects at moderate cardiovascular risk.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"39 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143862138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbial Insights: The Role of Diet in Modulating Gut Microbiota and Metabolites After Acute Coronary Syndrome 微生物洞察:急性冠状动脉综合征后饮食在调节肠道微生物群和代谢物中的作用
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-22 DOI: 10.1002/mnfr.70046
Raquel López-Gálvez, Esteban Orenes-Piñero, José Miguel Rivera-Caravaca, Fernando Pérez-Sanz, María Pilar Ramos-Bratos, Marta Isabel Roca, Darío Mandaglio-Collados, Cecilia López-García, Pablo Gil-Pérez, María Asunción Esteve-Pastor, Francisco Marín
{"title":"Microbial Insights: The Role of Diet in Modulating Gut Microbiota and Metabolites After Acute Coronary Syndrome","authors":"Raquel López-Gálvez, Esteban Orenes-Piñero, José Miguel Rivera-Caravaca, Fernando Pérez-Sanz, María Pilar Ramos-Bratos, Marta Isabel Roca, Darío Mandaglio-Collados, Cecilia López-García, Pablo Gil-Pérez, María Asunción Esteve-Pastor, Francisco Marín","doi":"10.1002/mnfr.70046","DOIUrl":"https://doi.org/10.1002/mnfr.70046","url":null,"abstract":"Acute coronary syndrome (ACS) is a leading cause of global mortality, largely due to atherosclerosis influenced by lifestyle factors like diet. Gut microbiota impacts lipid metabolism, inflammation, and endothelial function, all vital in atherosclerosis. Dysbiosis increases intestinal permeability, causing inflammation and plaque instability, elevating cardiac event risk. This study investigates the impact of dietary improvements on gut microbiota and metabolite release in recent ACS patients versus healthy individuals. A cohort of 29 recent ACS patients receiving lipid-lowering therapy and dietary advice was analyzed alongside 56 healthy controls. Dietary habits, serum, and stool samples were collected at admission and after 3 months. Metagenomic analysis of stool and metabolomic analysis of serum were conducted. The results showed bacterial dysbiosis in ACS patients, characterized by a reduction in beneficial genera and an increase in potentially pro-inflammatory bacteria. After 3 months of dietary improvements, three metabolites with anti-inflammatory properties were significantly upregulated. The findings highlight the association between gut microbiota dysbiosis, fatty diets, and inflammation in ACS patients. The observed increase in anti-inflammatory metabolites following dietary changes underscore the following dietary interventions in modulating gut microbiota and improving cardiovascular and metabolic health.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"29 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Total Antioxidant Capacity Can Modify the Effects of Apo-B Polymorphisms (Ins/Del and EcoRI) on Lipid Profiles and Atherogenic Indices Between Diabetic Patients 膳食总抗氧化能力可改变载脂蛋白b多态性(Ins/Del和EcoRI)对糖尿病患者血脂和动脉粥样硬化指标的影响
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-21 DOI: 10.1002/mnfr.70009
Faezeh Abaj, Masoumeh Rafiee, Ronak Nikbazm, Ehsan Alvandi, Fariba Koohdani
{"title":"Dietary Total Antioxidant Capacity Can Modify the Effects of Apo-B Polymorphisms (Ins/Del and EcoRI) on Lipid Profiles and Atherogenic Indices Between Diabetic Patients","authors":"Faezeh Abaj, Masoumeh Rafiee, Ronak Nikbazm, Ehsan Alvandi, Fariba Koohdani","doi":"10.1002/mnfr.70009","DOIUrl":"https://doi.org/10.1002/mnfr.70009","url":null,"abstract":"We aimed to study the role of Apolipoprotein B (Apo-B) polymorphisms (Ins/Del and EcoRI) and genotype interaction on lipid profiles and atherogenic indices in response to changes in dietary total antioxidant capacity (DTAC) of diet. This cross-sectional study consisted of 700 diabetic patients. Biochemical markers including total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), superoxide dismutase (SOD), C-reactive protein (CRP), total antioxidant capacity (TAC), interlukin-18 (IL-18), and Prostaglandin F2α (PGF2α) were measured based on standard protocols. Genotyping of the Apo-B polymorphisms was conducted by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Subjects with Ins/Ins genotype with higher DTAC intake had lower TG, AIP, and AC compared to Del-allele carriers. Moreover, A-allele carriers (EcoRI) with a higher median intake of DTAC had lower body mass index (BMI) and waist circumference (WC) compared to GG homozygotes. For combined genotypes, the EcoRI only variant (Ins/Ins and AA + AG) with higher DTAC intake had lower BMI and WC. Moreover, Ins/Del only variant (Ins/del + del/del and GG) with more adherence to DTAC had higher TG and AIP. Our study showed that Apo-B polymorphisms interact with the antioxidant capacity of diet to ameliorate the risk of cardio-metabolic diseases, especially atherosclerosis in the A carriers of EcoR1 and Ins/Ins homozygous of Ins/Del polymorphism.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"385 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study 12周石榴汁干预对炎症性肠病患者降低粪便钙保护蛋白水平的转录反应的调节作用的证据:一项原理证明研究的结果
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-21 DOI: 10.1002/mnfr.70067
Ilaria Minato, Pedro Mena, Luigi Ricciardiello, Eleonora Scaioli, Andrea Belluzzi, Enrica Rotondo, Eleonora Derlindati, Barbara Montanini, Costanza Michelini, Nicole Tosi, Vicente Agullò Garcià, Gianfranco Picone, Carlo Mengucci, Sara Dobani, Paloma Salamanca, Alice Rosi, Margherita Dall'Asta, Letizia Bresciani, Claudio Curti, Enzo Spisni, Alessandra Dei Cas, Alessandra Bordoni, Francisco A. Tomás‐Barberán, Lynnette R. Ferguson, Daniele Del Rio, Francesca Danesi
{"title":"Evidence for a Modulatory Effect of a 12‐Week Pomegranate Juice Intervention on the Transcriptional Response in Inflammatory Bowel Disease Patients Reducing Fecal Calprotectin Levels: Findings From a Proof‐of‐Principle Study","authors":"Ilaria Minato, Pedro Mena, Luigi Ricciardiello, Eleonora Scaioli, Andrea Belluzzi, Enrica Rotondo, Eleonora Derlindati, Barbara Montanini, Costanza Michelini, Nicole Tosi, Vicente Agullò Garcià, Gianfranco Picone, Carlo Mengucci, Sara Dobani, Paloma Salamanca, Alice Rosi, Margherita Dall'Asta, Letizia Bresciani, Claudio Curti, Enzo Spisni, Alessandra Dei Cas, Alessandra Bordoni, Francisco A. Tomás‐Barberán, Lynnette R. Ferguson, Daniele Del Rio, Francesca Danesi","doi":"10.1002/mnfr.70067","DOIUrl":"https://doi.org/10.1002/mnfr.70067","url":null,"abstract":"<jats:label/>This study aimed at investigating the effects of pomegranate juice (POMJ) consumption on inflammatory biomarkers and gene expression in patients with inflammatory bowel disease (IBD) in clinical remission. In this randomized, placebo‐controlled trial, 16 subjects with IBD in remission consumed POMJ or placebo for 12 weeks. POMJ consumption significantly reduced fecal calprotectin (FC) and plasma endotoxin levels. Transcriptomic analysis of peripheral blood mononuclear cells revealed upregulation of genes involved in mucosal immunity, including aryl hydrocarbon receptor (<jats:italic>AHR</jats:italic>), neutrophil cytosolic factor 4 (<jats:italic>NCF4</jats:italic>), and nuclear factor, interleukin 3 regulated (<jats:italic>NFIL3</jats:italic>). Urolithin metabotypes were predominantly of the B type, associated with intestinal dysbiosis. No significant changes were observed in serum inflammatory markers or colonic mucosal cytokine expression. POMJ consumption reduced markers of intestinal inflammation and modulated gene expression related to mucosal immunity and barrier function in patients with IBD. These findings suggest the potential of POMJ as a beneficial dietary intervention for maintaining remission in IBD, highlighting the promise of targeted nutritional strategies in managing chronic inflammatory conditions. Further research is needed to elucidate the long‐term clinical implications of these molecular changes.Trial RegistrationClinicalTrials.gov identifier: <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://clinicaltrials.gov/ct2/show/NCT03000101\">NCT03000101</jats:ext-link>.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Quercetin Metabolites on Glucose-Dependent Lipid Accumulation in 3T3-L1 Adipocytes 槲皮素代谢物对 3T3-L1 脂肪细胞中葡萄糖依赖性脂质积累的影响
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-21 DOI: 10.1002/mnfr.70070
Marco Rendine, Samuele Venturi, Mirko Marino, Claudio Gardana, Peter Møller, Daniela Martini, Patrizia Riso, Cristian Del Bo
{"title":"Effects of Quercetin Metabolites on Glucose-Dependent Lipid Accumulation in 3T3-L1 Adipocytes","authors":"Marco Rendine, Samuele Venturi, Mirko Marino, Claudio Gardana, Peter Møller, Daniela Martini, Patrizia Riso, Cristian Del Bo","doi":"10.1002/mnfr.70070","DOIUrl":"https://doi.org/10.1002/mnfr.70070","url":null,"abstract":"The aim of the study was to assess the effects of quercetin metabolites (QMs) on lipid accumulation in adipocytes under high-glucose and physiological-glucose concentrations and to elucidate the mechanisms involved. 3T3-L1 mature adipocytes were exposed to a physiological glucose concentration, as a model of caloric restriction (CR), or high glucose (control), with and without QMs (quercetin-3-glucuronide [Q3G] and isorhamnetin [ISOR]). Cells were treated with Q3G (0.3 and 0.6 µmol/L) and ISOR (0.2 and 0.4 µmol/L) for 48 h. Lipid accumulation (Oil Red O staining) and Δ glucose level (HPLC) were assessed. Under high glucose, Q3G and ISOR reduced lipid accumulation (−10.8% and −10.4%; <i>p</i> &lt; 0.01) and Δ glucose level (−13.6% and −14.2%; <i>p</i> &lt; 0.05). Under CR, QMs increased Δ glucose level (+21.6% for Q3G and +21% for ISOR; <i>p</i> &lt; 0.05). ISOR increased pAMPK levels under high glucose (+1.4-fold; <i>p</i> &lt; 0.05). Under CR, Q3G and ISOR increased pAMPK (+1.4- and +1.5-fold; <i>p</i> &lt; 0.05), while ISOR upregulated SIRT1 and PGC-1α (+2.3- and +1.5-fold; <i>p</i> &lt; 0.05). Findings support, for the first time, the potential contribution of QMs, especially ISOR, in the regulation of lipid metabolism in vitro, possibly via AMPK activation. Further studies, including in vivo, are encouraged to strengthen evidence of the mechanisms observed.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"28 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sesquiterpene Lactone Lactucopicrin Boosts Apoptotic Cell Clearance by Colonic Epithelial Cells and Alleviates Colitis in Mice 倍半萜内酯内酯苦苷促进小鼠结肠上皮细胞对凋亡细胞的清除并减轻结肠炎
IF 5.2 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2025-04-18 DOI: 10.1002/mnfr.70062
Yushi Du, Shuangshuang Li, Guanyu Chen, Yihui Mao, Shasha Zhu, Wenyu Zhang, Mengxi Kang, Yi Sui, Dongliang Wang
{"title":"Sesquiterpene Lactone Lactucopicrin Boosts Apoptotic Cell Clearance by Colonic Epithelial Cells and Alleviates Colitis in Mice","authors":"Yushi Du, Shuangshuang Li, Guanyu Chen, Yihui Mao, Shasha Zhu, Wenyu Zhang, Mengxi Kang, Yi Sui, Dongliang Wang","doi":"10.1002/mnfr.70062","DOIUrl":"https://doi.org/10.1002/mnfr.70062","url":null,"abstract":"Boosting apoptotic cell clearance by phagocytes including colonic epithelial cells (CECs), a process named efferocytosis, inhibits colitis development. Lactucopicrin (LCP), one common bitter sesquiterpene lactone affluent in leafy vegetables possesses a significant antiinflammatory property. However, it remains unknown whether LCP could regulate CECs efferocytosis and colitis development in vivo. Methods and Results: LCP (0.25-1 µmol/L) does not appreciably change the efferocytic capacity of murine primary CECs to clear apoptotic CECs. Instead, LCP dose-dependently increases the efferocytic capacity of CECs treated with butyrate (But). This effect is reliant on efferocytic receptor brain-specific angiogenesis 1 (BAI1). Although LCP does not significantly affect BAI1 expression, it alters BAI1 distribution with an increase in lipid raft microdomains in plasma membrane, an effect responsible for the LCP effect on efferocytic capacity. Moreover, dietary supplementation with 0.012% wt/wt of LCP attenuates dextran sulfate sodium (DSS)-induced colitis in C57BL/6J mice, along with an increase in efferocytic capacity of CECs and fecal But content, a reduction in apoptotic cell accumulation and inflammation burden in colonic tissues. Conclusion: Dietary LCP could inhibit DSS-induced colitis in mice, likely through enhancing BAI1-mediated efferocytosis of CECs, thus providing a new candidate for the treatment of colitis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"16 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信