Molecular Nutrition & Food Research最新文献_第2页

The Combination of Indole-3-Carbinol and Tryptophan Provides Additive Benefits in Enhancing Innate Immunity Against Salmonella Colitis in Mice. 吲哚-3-甲醇和色氨酸联合使用可增强小鼠对沙门氏菌结肠炎的先天免疫。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-28 DOI: 10.1002/mnfr.70265

Fu-Chen Huang,Shun-Chen Huang

{"title":"The Combination of Indole-3-Carbinol and Tryptophan Provides Additive Benefits in Enhancing Innate Immunity Against Salmonella Colitis in Mice.","authors":"Fu-Chen Huang,Shun-Chen Huang","doi":"10.1002/mnfr.70265","DOIUrl":"https://doi.org/10.1002/mnfr.70265","url":null,"abstract":"Salmonella spp. remains a significant global public health concern, capable of causing a spectrum of diseases. The aryl hydrocarbon receptor (AhR) is known to confer protective effects in Salmonella-induced colitis. Although indole-3-carbinol (I3C) and tryptophan (Trp) are known dietary sources of AhR ligands, their combined effects on Salmonella pathogenesis have yet to be fully characterized. We employed a well-established Salmonella colitis model using 6-8-week-old female C57BL/6 mice to evaluate the combined effects of I3C and Trp. Mice were pretreated with oral gavage of I3C (100 mg/kg/day), Trp (100 mg/kg/day), or both for seven consecutive days before infection. The I3C + Trp combination significantly alleviated clinical signs of colitis, reduced cecal mRNA expression of proinflammatory cytokines (IL-1β, IL-6, CXCL2, IL-17α), and increased expression of immune-modulating genes (IL-22, CRAMP, ATG16L1) compared to individual treatments. Immunohistochemical staining revealed decreased zonulin and claudin-2, and increased occludin, AhR, and vitamin D receptor expression in the cecal mucosa. The combination of I3C and Trp exerts additive protective effects against Salmonella-induced colitis by modulating host immune responses and enhancing epithelial barrier integrity. These results suggest dietary AhR ligands may serve as a promising complementary approach for the prevention and management of invasive salmonellosis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"96 1","pages":"e70265"},"PeriodicalIF":5.2,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quinoa Polyphenols Alleviate Glucose Deprivation-Induced Endoplasmic Reticulum Stress by Enhancing Hepatic Cellular Autophagy and Antioxidant Capacity. 藜麦多酚通过增强肝细胞自噬和抗氧化能力减轻葡萄糖剥夺诱导的内质网应激。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-27 DOI: 10.1002/mnfr.70279

Qiang Gao,Mingcong Fan,Haifeng Qian,Yan Li,Li Wang

{"title":"Quinoa Polyphenols Alleviate Glucose Deprivation-Induced Endoplasmic Reticulum Stress by Enhancing Hepatic Cellular Autophagy and Antioxidant Capacity.","authors":"Qiang Gao,Mingcong Fan,Haifeng Qian,Yan Li,Li Wang","doi":"10.1002/mnfr.70279","DOIUrl":"https://doi.org/10.1002/mnfr.70279","url":null,"abstract":"Glucose deprivation induces ER stress, oxidative damage, and apoptosis, contributing to hepatic dysfunction. This study explores the protective effects and mechanisms of quinoa-derived polyphenols (QPs) under glucose-deprived conditions. HepG2 and Huh7 cells were exposed to QPs at 100 or 200 µg/mL for 12 or 24 h under glucose-deprived conditions, while male mice received QPs by gavage at 40 or 80 mg/kg/day for 14 days, followed by a single intraperitoneal injection of 2-deoxy-D-glucose (2-DG, 400 mg/kg) to induce ER stress. QPs significantly reduced ER stress markers (GRP78, p-IRE1, XBP1s), restored mitochondrial membrane potential, and attenuated apoptosis. QPs also activated the Nrf2/HO-1 antioxidant pathway and improved redox homeostasis. Additionally, QPs enhanced autophagic flux, as evidenced by increased LC3B2, ATG4B, and Beclin 1 and reduced SQSTM1. Pharmacological inhibition studies revealed that autophagy plays a critical role in the QP-mediated relief of ER stress. In vivo, QPs improved hepatic function and suppressed ER stress induced by 2-deoxyglucose. QPs protect hepatocytes from glucose deprivation-induced ER stress and apoptosis by enhancing antioxidant capacity and autophagy. These findings provide new insight into the dietary potential of quinoa polyphenols in preventing metabolic stress-related liver injury.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"101 1","pages":"e70279"},"PeriodicalIF":5.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo-Inositol Supplementation During Suckling 哺乳期间补充肌醇对不良妊娠状况的性别特异性持久代谢组效应及预防

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-25 DOI: 10.1002/mnfr.70274

Rocío A. Martín-Chamorro, Jean-Charles Martin, Pedro Castillo, Mariona Palou, Andreu Palou, Ana María Rodríguez, Catalina Picó

{"title":"Sex-Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo-Inositol Supplementation During Suckling","authors":"Rocío A. Martín-Chamorro, Jean-Charles Martin, Pedro Castillo, Mariona Palou, Andreu Palou, Ana María Rodríguez, Catalina Picó","doi":"10.1002/mnfr.70274","DOIUrl":"https://doi.org/10.1002/mnfr.70274","url":null,"abstract":"This study examines the protective effects of myo-inositol supplementation during suckling on long-term negative outcomes caused by fetal energy restriction, using a metabolomics approach.Offspring of rats from both control and 25% gestational calorie-restricted dams received either myo-inositol or the vehicle during suckling and were exposed to a Western diet (WD) between 5 and 7 months of age. Metabolomics analysis of plasma samples at 7 months allowed the identification of 164 metabolites, revealing marked sex differences to gestational restriction. In males, maternal calorie restriction resulted in alterations in 19 metabolites, while only six metabolites showed significant variations in females, consistent with a lower impact of gestational calorie restriction (GCR) on the adult phenotype. Supplementation with myo-inositol normalized the levels of 16 metabolites in males and all six in females. Functionally, myo-inositol mostly targeted liver-associated functions in males and metabolic control functions in females. Mild/moderate GCR leads to significant changes in the metabolomic profiles of adult offspring, with males experiencing higher metabolic alterations. Early postnatal myo-inositol supplementation may be a promising strategy to alleviate the negative metabolic effect of maternal undernutrition. Sex-specific differences in the metabolomic response emphasize the necessity of considering both sexes for effective interventions.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"95 1","pages":"e70274"},"PeriodicalIF":5.2,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Effects and Mechanisms of Steviol Glycosides on Glucose Metabolism: Evidence From Preclinical Studies” 更正“甜菊糖苷对葡萄糖代谢的影响和机制：来自临床前研究的证据”

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-25 DOI: 10.1002/mnfr.70276

引用次数: 0

Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study. 食物基质对鼠李糖乳杆菌CRL1505存活到胃肠道转运的影响：一项随机、对照、交叉研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-20 DOI: 10.1002/mnfr.70272

Nicola Mangieri,Viola Termine,Giorgio Gargari,Nicolò Fornasari,Michele Isotti,Susana Salva,Julio Villena,María Pía Taranto,Valentina Taverniti,Susana Álvarez,Graciela Font,Ylenia Zanchetta,Stefania Arioli,Diego Mora

{"title":"Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.","authors":"Nicola Mangieri,Viola Termine,Giorgio Gargari,Nicolò Fornasari,Michele Isotti,Susana Salva,Julio Villena,María Pía Taranto,Valentina Taverniti,Susana Álvarez,Graciela Font,Ylenia Zanchetta,Stefania Arioli,Diego Mora","doi":"10.1002/mnfr.70272","DOIUrl":"https://doi.org/10.1002/mnfr.70272","url":null,"abstract":"Probiotic survival is crucial for their beneficial effect, but only a few studies have assessed the impact of delivery format on probiotic viability after passage through the gastrointestinal tract.Our study aimed to investigate the survival of Lacticaseibacillus rhamnosus (L. rhamnosus) CRL1505 through the gastrointestinal transit in healthy volunteers after a daily consumption of at least 1 billion CFUs per day administered as freeze-dried cells or incorporated into oat- and milk-fermented drinks. The probiotic's survival was evaluated by combining culture-based and molecular techniques. Our findings revealed that L. rhamnosus CRL1505 survival was significantly higher when the probiotic was administered as an oat- and as a milk-fermented drink. The study highlighted the persistence of CRL1505 in a subset of volunteers 1 week after the last administration. The metataxonomic analysis of fecal samples did not reveal significant changes in microbiota diversity among treatment groups, as expected after probiotic administration in healthy subjects.The survival of CRL1505 through the human gastrointestinal tract was demonstrated with and without the protection of food matrices, highlighting the strain's remarkable ability to withstand harsh conditions. Our findings emphasize the importance of food matrix selection for improving probiotic viability and its potential efficacy in functional foods.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"18 1","pages":"e70272"},"PeriodicalIF":5.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordyceps-Fermented Chinese Jujube Ameliorates Oxidative Stress and Restores Gut Microbiome in Alcohol-Induced Liver Injury in Mice. 冬虫夏草发酵大枣改善小鼠酒精性肝损伤的氧化应激和恢复肠道微生物群

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-20 DOI: 10.1002/mnfr.70243

Tin Ei Cho,Ying Meng,Guoying Zhang,Jianya Ling

{"title":"Cordyceps-Fermented Chinese Jujube Ameliorates Oxidative Stress and Restores Gut Microbiome in Alcohol-Induced Liver Injury in Mice.","authors":"Tin Ei Cho,Ying Meng,Guoying Zhang,Jianya Ling","doi":"10.1002/mnfr.70243","DOIUrl":"https://doi.org/10.1002/mnfr.70243","url":null,"abstract":"This research investigated the influence of Chinese jujube fermented with Cordyceps kyushuensis extracts on mice with alcohol-induced liver injury (ALI). Our findings highlighted the antioxidant properties of these extracts through various assays and demonstrated potential biochemical effects in ALI mice. We explored the impact of the fermentation extracts on gut microbiota, revealing both quantitative and qualitative modifications through 16S rDNA amplicon sequencing of intestinal flora. The fermentation extracts exhibited antioxidant and anti-inflammatory effects while also regulating lipid metabolism. Research indicates that differences in gut microbiota composition affect susceptibility to ALI. The unique OTUs identified in the three groups (Normal, EtOH, and High CK) were 108, 60, and 62, respectively. These fermentation extracts positively influenced specific gut microbiota by increasing the abundance of advantageous microorganisms such as Akkermansia, Adlercreutzia, Lactobacillus, and Angelakisella within the gut microenvironment. In conclusion, this research enhances our understanding of the mechanisms underlying the fermentation of jujube fruit with Cordyceps fungi, the pathogenesis of ALI, and the functional role of intestinal microbiota.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"1 1","pages":"e70243"},"PeriodicalIF":5.2,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardioprotective Effect of Gamma-Oryzanol on Myocardium Proteome of Rats Submitted to Diet-Induced Obesity. γ -谷维醇对饮食性肥胖大鼠心肌蛋白质组的心脏保护作用。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-18 DOI: 10.1002/mnfr.70239

Jéssica Leite Garcia, Alfonsina D'Amato, Juliana Silva Siqueira, Fabiane Valentini Francisqueti-Ferron, Cristina Schmitt Gregolin, Silméia Garcia Zanati Bazan, Artur Junio Togneri Ferron, Luis Eduardo Sormani, Taynara Aparecida Vieira, Bianca Pereira Lopes, Dijon Henrique Salomé de Campos, Guilherme Ribeiro Romualdo, Giancarlo Aldini, Camila Renata Correa

{"title":"Cardioprotective Effect of Gamma-Oryzanol on Myocardium Proteome of Rats Submitted to Diet-Induced Obesity.","authors":"Jéssica Leite Garcia, Alfonsina D'Amato, Juliana Silva Siqueira, Fabiane Valentini Francisqueti-Ferron, Cristina Schmitt Gregolin, Silméia Garcia Zanati Bazan, Artur Junio Togneri Ferron, Luis Eduardo Sormani, Taynara Aparecida Vieira, Bianca Pereira Lopes, Dijon Henrique Salomé de Campos, Guilherme Ribeiro Romualdo, Giancarlo Aldini, Camila Renata Correa","doi":"10.1002/mnfr.70239","DOIUrl":"https://doi.org/10.1002/mnfr.70239","url":null,"abstract":"Cardiovascular disease (CVD) is a public health issue comprising approximately 17.9 million deaths annually. The causes of CVD are multifactorial, with obesity being a significant contributing factor. Gamma-oryzanol (Oz) is a bioactive compound whose beneficial effects on chronic metabolic diseases have been reported. Therefore, this study aimed to investigate the gamma-oryzanol effect on the myocardium proteome of rats submitted to a high sugar-fat diet consumption. Wistar rats were randomly distributed into the following three groups (n = 6/group): Control, High sugar-fat (HSF), and HSF + Oz for 30 weeks. We evaluated nutritional, metabolic, and hormonal profiles to verify obesity induction and its metabolic outcomes. Cardiac morphology and function were evaluated by an echocardiography study, and the presence of cardiac fibrosis was assessed by histological analysis. Next, we applied the proteomics approach in cardiac tissue. Our results revealed that gamma-oryzanol prevented the outcomes induced by the HSF diet, including cardiac dysfunction and fibrosis. The compound prevented the alterations of the myocardium proteome, highlighted by the modulation of lipid metabolism, fibrosis, cardiac contractility, eukaryotic initiation factor (EIF2) pathway, and the sirtuin signaling pathway. Gamma-oryzanol presents a cardioprotective effect on proteome changes in rats with diet-induced obesity.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70239"},"PeriodicalIF":4.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KEGGaNOG: A Lightweight Tool for KEGG Module Profiling From Orthology-Based Annotations. KEGGaNOG：一个轻量级的KEGG模块分析工具。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-18 DOI: 10.1002/mnfr.70269

Ilia V Popov, Michael L Chikindas, Koen Venema, Alexey M Ermakov, Igor V Popov

{"title":"KEGGaNOG: A Lightweight Tool for KEGG Module Profiling From Orthology-Based Annotations.","authors":"Ilia V Popov, Michael L Chikindas, Koen Venema, Alexey M Ermakov, Igor V Popov","doi":"10.1002/mnfr.70269","DOIUrl":"https://doi.org/10.1002/mnfr.70269","url":null,"abstract":"Functional interpretation of bacterial genomes and metagenomes is essential for applications ranging from microbial ecology to probiotic development. KEGGaNOG is a lightweight and scalable Python tool that enables pathway-level profiling by translating orthology-based annotations into KEGG module completeness scores. KEGGaNOG accepts input from eggNOG-mapper annotations and supports both individual genome and multi-sample analyses. It calculates completeness scores for KEGG modules using internally integrated KEGG-Decoder logic and offers a suite of visualization options, including heatmaps, grouped summaries, barplots, radar plots, and correlation networks. We demonstrate its use on 11 well-characterized bacterial genomes, including several probiotic strains. KEGGaNOG accurately captured core biosynthetic capabilities and highlighted functionally informative differences across samples, such as vitamin biosynthesis, stress-response pathways, and transport systems. KEGGaNOG provides a practical framework for high-throughput functional annotation and comparative metabolic profiling in bacterial genomics and microbiome research. It is particularly well suited for preliminary analysis of novel or uncharacterized strains and is applicable to both isolate and metagenome-derived data. In the context of probiotic research, KEGGaNOG supports mechanistic exploration and strain selection by linking genomic content to functional capacity in a reproducible and interpretable manner.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70269"},"PeriodicalIF":4.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S-5-Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study. 基于SF68、植物甾醇和6s -5-甲基四氢叶酸的益生菌制剂对超重/肥胖受试者的身体组成、生化参数、肠道微生物群以及胃肠道和一般症状的影响：probity研究

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-18 DOI: 10.1002/mnfr.70198

Giuditta Pagliai, Simone Baldi, Marta Tristan Asensi, Ilaria Giangrandi, Sofia Lotti, Alessia Bertelli, Francesco Cei, Sara Bertorello, Gianluca Bartolucci, Serena Borghi, Amedeo Amedei, Matteo Becatti, Claudia Fiorillo, Anna Maria Gori, Rossella Marcucci, Barbara Colombini, Francesco Sofi

{"title":"Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S-5-Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study.","authors":"Giuditta Pagliai, Simone Baldi, Marta Tristan Asensi, Ilaria Giangrandi, Sofia Lotti, Alessia Bertelli, Francesco Cei, Sara Bertorello, Gianluca Bartolucci, Serena Borghi, Amedeo Amedei, Matteo Becatti, Claudia Fiorillo, Anna Maria Gori, Rossella Marcucci, Barbara Colombini, Francesco Sofi","doi":"10.1002/mnfr.70198","DOIUrl":"https://doi.org/10.1002/mnfr.70198","url":null,"abstract":"Obesity and dyslipidemia are increasingly widespread. Considering gut microbiota's (GM) role in energy balance, probiotics represent a promising non-pharmacological approach. This study assessed a probiotic formulation (SF68 + phytosterols + (6S)-5-methyltetrahydrofolic acid) on anthropometric, biochemical, and GM parameters, as well as gastrointestinal and general symptoms, in overweight/obese individuals with low-to-moderate cardiovascular risk. Forty participants (30F, mean age 51.5 ± 11 years) were randomized to receive either the probiotic or placebo daily for 12 weeks. Anthropometric data, questionnaires, and biological samples were collected pre- and post-intervention. While both groups showed significant (p < 0.05) improvements, the probiotic group showed greater reductions in waist circumference (-1.8 cm), fat mass (-1.8 kg; -1.7%), total cholesterol (-11 mg/dL), and LDL-cholesterol (-10.3 mg/dL), along with an increased HDL/LDL ratio (+0.1). Both probiotic and placebo resulted in a significant reduction in HbA1c (-1.7 mmol/mol and -1.5 mmol/mol, respectively). The probiotic formulation also reduced erythrocyte ROS (-29.7%), granulocyte ROS (-28.4%), and plasma nitrite/nitrate (49.5%) and significantly increased erythrocyte glutathione (GSH; +81.9%). Gastrointestinal symptoms improved, and GM analysis showed an increased Evenness index and reduced Lachnospirales abundance after probiotic treatment. These findings suggest the multi-component probiotic formulation may support metabolic and gut health in overweight or obese individuals, although further research is warranted.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70198"},"PeriodicalIF":4.2,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upcycled Beverage From Roasted Açaí (Euterpe oleracea) Seeds: Antioxidant Capacity and Cytoprotection Through Gastrointestinal Simulation. 从烘焙Açaí （Euterpe oleracea）种子中提取的升级饮料：通过胃肠道模拟的抗氧化能力和细胞保护。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-16 DOI: 10.1002/mnfr.70270

Layane Rosa da Silva,Luis Henrique Felix Feitosa,Matheus Bezerra E Silva,Gezaildo Dos Santos Silva,Eike Guilherme Torres de Souza,Antonia Dayane Jenyffer de Farias Marques,Eduarda Spagnol Sacilotto,Narciza Maria de Oliveira Arcanjo,Marcos Dos Santos Lima,Maria Teresa Bertoldo Pacheco,Fabiana Galland,Marta Suely Madruga,Ana Rita Ribeiro de Araújo Cordeiro,Taliana Kênia Alencar Bezerra

{"title":"Upcycled Beverage From Roasted Açaí (Euterpe oleracea) Seeds: Antioxidant Capacity and Cytoprotection Through Gastrointestinal Simulation.","authors":"Layane Rosa da Silva,Luis Henrique Felix Feitosa,Matheus Bezerra E Silva,Gezaildo Dos Santos Silva,Eike Guilherme Torres de Souza,Antonia Dayane Jenyffer de Farias Marques,Eduarda Spagnol Sacilotto,Narciza Maria de Oliveira Arcanjo,Marcos Dos Santos Lima,Maria Teresa Bertoldo Pacheco,Fabiana Galland,Marta Suely Madruga,Ana Rita Ribeiro de Araújo Cordeiro,Taliana Kênia Alencar Bezerra","doi":"10.1002/mnfr.70270","DOIUrl":"https://doi.org/10.1002/mnfr.70270","url":null,"abstract":"Acai seeds have been used in roasting processes, resulting in a percolated beverage similar to coffee. This upcycled product has gained market share, offering consumers a caffeine-free beverage with functional appeal. However, information about the powder and beverage is limited. Thus, this research aimed to evaluate the chemical profile of roasted acai seed samples from Brazil, investigate phenolic compounds and antioxidant activity before and after in vitro digestion, and examine the cytotoxic/cytoprotective effects in Caco-2 cell cultures. Six commercial samples from the North, Northeast, and Southeast were characterized by high carbohydrate content, high acidity, and moisture content according to legislation (≤5 g/100 g). After in vitro digestion, all beverages exhibited higher concentrations of tannins and flavonoids and greater capacity to absorb oxygen radicals. However, there was a reduction in antioxidant potential against DPPH and ABTS radicals and in the reducing action of ferric ions. The samples produced in the North and Northeast showed similarity in the phenolic profile compared to those made in the Southeast. They were characterized by chlorogenic acids, vinylic acid, and syringic acid, which are associated with phenolic markers. All beverages demonstrated low cytotoxicity (>90%) and showed cytoprotective effects, indicating that the samples prevented oxidation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"36 1","pages":"e70270"},"PeriodicalIF":5.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145072060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0