Molecular Nutrition & Food Research最新文献_第2页

Apigenin Alleviates Intestinal Ischemia/Reperfusion Injury via Upregulating Nrf2-Mediated Tight Junction Integrity

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-27 DOI: 10.1002/mnfr.70043

Bin Xu, Yan Zhuang, Ying Zhang, Suoning Liu, Rongjun Fan, Weiru Jiang

{"title":"Apigenin Alleviates Intestinal Ischemia/Reperfusion Injury via Upregulating Nrf2-Mediated Tight Junction Integrity","authors":"Bin Xu, Yan Zhuang, Ying Zhang, Suoning Liu, Rongjun Fan, Weiru Jiang","doi":"10.1002/mnfr.70043","DOIUrl":"https://doi.org/10.1002/mnfr.70043","url":null,"abstract":"Epithelial barrier dysfunction, critically involved in intestinal ischemia/reperfusion (I/R) injury, is significantly regulated by Nrf2-mediated oxidative stress. Apigenin, a flavonoid commonly found in fruits and vegetables with diverse biological properties, has an unclear impact on intestinal I/R injury. We hypothesize that apigenin improves intestinal barrier dysfunction by activating Nrf2 signaling. Thirty rats were randomly divided into five groups to establish an I/R model using superior mesenteric artery occlusion. Hypoxia and re-oxygenation (H/R) model was developed utilizing Caco-2 and IEC-6 cells, which were exposed to hypoxic conditions followed by re-oxygenation. Apigenin protected against intestinal mucosal damage by suppressing inflammatory cytokines release (TNF-α, IL-1β, IL-6, MPO, p < 0.01), ameliorating oxidative stress (MDA, SOD, GSH, GSH-Px, p < 0.01), and improving barrier dysfunction (DAO and TEER, p < 0.01) both in vivo and in vitro, without causing significant changes in the corresponding normal controls (p > 0.05). Apigenin up-regulated the protein expression of Nrf2, HO-1, and tight junction (TJ) proteins (p < 0.01). Furthermore, the knockdown of Nrf2 significantly abrogated apigenin-enhanced the TJ expression. Apigenin pretreatment alleviates intestinal I/R-induced barrier damage through Nrf2 activation and TJ upregulation, offering new strategies for preventing or treating I/R-associated intestinal diseases.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"41 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenols: Potential Applications in Cancer Therapy

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-27 DOI: 10.1002/mnfr.70011

María Oriol-Caballo, María Paz Moreno-Murciano, Rafael López-Blanch, José M. Estrela, Elena Obrador

{"title":"Polyphenols: Potential Applications in Cancer Therapy","authors":"María Oriol-Caballo, María Paz Moreno-Murciano, Rafael López-Blanch, José M. Estrela, Elena Obrador","doi":"10.1002/mnfr.70011","DOIUrl":"https://doi.org/10.1002/mnfr.70011","url":null,"abstract":"Polyphenols (PFs) are compounds found in fruits and vegetables, known for their health-related benefits, mainly including antioxidant, antiinflammatory, and anticancer properties. However, their efficacy is limited by poor bioavailability due to issues like low solubility, rapid metabolism, and extensive excretion. Thus, research has focused on improving delivery systems, such as, for example, nanoparticles, hydrogels, cocrystals, or conjugation with carrier molecules, which may protect PFs from degradation, improve solubility, and/or facilitate targeted delivery to cancer cells. PFs are promising in modulating cancer-related pathways like cell proliferation and death, or metastatic invasion, though their translation to patients is hindered by bioavailability and complex cancer mechanisms. This review analyzes factors that affect PF bioavailability, evidences of in vivo effects in animal models and their mechanisms, results from clinical trials, and strategies to enhance bioavailability. The idea that PFs need to directly interact with the cancer cell is challenged. Future research aims to optimize delivery systems, combine PFs with standard treatments, and explore their epigenetic effects, modulation of the tumor microenvironment, and interactions with gut microbiota. Advances in personalized medicine and structural modifications to improve stability and absorption could further enhance PF anticancer potential. Despite challenges, PFs remain a promising avenue for complementary oncotherapy solutions.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"61 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ProbML: A Machine Learning-Based Genome Classifier for Identifying Probiotic Organisms

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-26 DOI: 10.1002/mnfr.70025

Arjun Orkkatteri Krishnan, Lalit N. Mudgal, Vishesh Soni, Tulika Prakash

{"title":"ProbML: A Machine Learning-Based Genome Classifier for Identifying Probiotic Organisms","authors":"Arjun Orkkatteri Krishnan, Lalit N. Mudgal, Vishesh Soni, Tulika Prakash","doi":"10.1002/mnfr.70025","DOIUrl":"https://doi.org/10.1002/mnfr.70025","url":null,"abstract":"Probiotics are microorganisms that offer health benefits to the host. Traditional methods for identifying these organisms are time-consuming and resource-intensive. This study addresses the need for a more efficient and accurate approach to probiotic identification using machine learning (ML) techniques. The present study introduces ProbML, an ML-based approach for identifying probiotic organisms from whole genome sequences of prokaryotes. Among the five ML algorithms tested, XGBoost models demonstrated superior performance, achieving a maximum accuracy of 100% on learning data and 95.45% on an independent test dataset. This surpasses existing tools, which achieved 97.77% and 66.28% accuracy on the same datasets, respectively. The ProbML models were used to analyze 4728 genomes in the Unified Human Gastrointestinal Genome database, classifying 650 genomes as probiotics, with many previously unreported. A versatile GUI platform was also developed that employs ProbML models for probiotic classification or can be used to generate custom ML classifiers based on user-specific needs (https://github.com/sysbio-iitmandi/MLG_Dashboard). This study emphasizes the power of genomic data and advanced ML techniques in accelerating probiotic discovery.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"47 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of 1,3-Dioleoyl-2-palmitoylglycerol on Intestine Structural and Functional Development in Early Life

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-24 DOI: 10.1002/mnfr.70051

Fang Wu, Yaqiong Liu, Ming Zhang, Xinlei Yuan, Yutong Jin, Yixuan Li, Ran Wang, Yanling Hao, Bing Fang

{"title":"Effects of 1,3-Dioleoyl-2-palmitoylglycerol on Intestine Structural and Functional Development in Early Life","authors":"Fang Wu, Yaqiong Liu, Ming Zhang, Xinlei Yuan, Yutong Jin, Yixuan Li, Ran Wang, Yanling Hao, Bing Fang","doi":"10.1002/mnfr.70051","DOIUrl":"https://doi.org/10.1002/mnfr.70051","url":null,"abstract":"1,3-Dioleoyl-2-palmitoyl-glycerol (OPO) is a specific triglyceride in human breast milk, and it has been added to infant formula to mimic human breast milk fat. Existing studies only focused on its effects on fatty acid and calcium absorption, as well as the intestinal microbial composition; however, effects of OPO on the early-life development of intestine were still unclear. Our study explored the effects of OPO on intestinal epithelial structure and barrier construction in neonatal mice and the involvement of intestinal microorganisms. OPO supplementation significantly increased the number of intestinal stem cells, which in turn promoted villus and crypt, and promoted goblet cell and Paneth cell differentiation. OPO also promotes epithelial barrier integrity by increasing the expression of mucin 2, lysozyme 1, and tight junction proteins. Furthermore, the benefits of OPO were associated with the higher abundance of beneficial bacteria (unclassified_f_Muribaculaceae, Akkermansia, Bifidobacterium, and Blautia) and elevated butyrate levels. This study demonstrates the efficacy of OPO on intestinal health in neonatal mice beyond defecation, expands the understanding of the biological functions of OPO, and expands its application in intestinal health products targeting special populations, such as the elderly or individuals with intestinal fragility or injury.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"61 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prenatal Intake of High Multivitamins or Folic Acid With or Without Choline Contributes to Gut Microbiota‐Associated Dysregulation of Serotonin in Offspring

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-24 DOI: 10.1002/mnfr.70044

Jianzhang Dong, Mali Al‐Issa, Jenny S. Feeney, Gia V. Shelp, Elizabeth M. Poole, Clara E. Cho

{"title":"Prenatal Intake of High Multivitamins or Folic Acid With or Without Choline Contributes to Gut Microbiota‐Associated Dysregulation of Serotonin in Offspring","authors":"Jianzhang Dong, Mali Al‐Issa, Jenny S. Feeney, Gia V. Shelp, Elizabeth M. Poole, Clara E. Cho","doi":"10.1002/mnfr.70044","DOIUrl":"https://doi.org/10.1002/mnfr.70044","url":null,"abstract":"The gut microbiota is amenable to early nutrition including micronutrients but intake above and below the recommendations commonly occur with unknown consequences. Serotonin (5‐hydroxytryptamine [5‐HT]) is a monoamine found centrally and peripherally with diverse functions such as food intake regulation via the hypothalamic 5‐HT receptor 2C (5‐HTR2C). This study determined the impact of prenatal micronutrients on the gut microbiota and serotonergic system in offspring. Pregnant Wistar rats were fed either recommended vitamins (RV), high vitamins (HV), high folic acid with recommended choline (HFRC), or high folic acid with no choline (HFNC). Offspring were fed a high‐fat diet for 12 weeks postweaning. HV, HFRC, and HFNC males and females had lower hypothalamic 5‐HTR2C protein expression compared to RV. Brain 5‐HT concentrations were lower but colon 5‐HT concentrations were higher in HV and HFNC males and females and HFRC males compared to RV. Refeeding response after 5‐HTR2C agonist was negatively correlated with hypothalamic 5‐HTR2C protein expression in males and with brain 5‐HT concentrations in females. Random forest revealed top bacterial taxa, which Lactococcus, Ruminococcus, Bacteroides, and Oscillospira showed significant correlations with refeeding response and concentrations of brain and colon 5‐HT. In conclusion, excess or imbalanced prenatal consumption of micronutrients leads to gut microbiota‐associated disturbances in the serotonergic system in offspring.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"64 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallic Acid Ameliorated Chronic DSS‐Induced Colitis Through Gut Microbiota Modulation, Intestinal Barrier Improvement, and Inflammation

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-24 DOI: 10.1002/mnfr.70024

Baoming Tian, Peng Ye, Xue Zhou, Jiangning Hu, Peiyi Wang, Ming Cai, Kai Yang, Peilong Sun, Xianguo Zou

{"title":"Gallic Acid Ameliorated Chronic DSS‐Induced Colitis Through Gut Microbiota Modulation, Intestinal Barrier Improvement, and Inflammation","authors":"Baoming Tian, Peng Ye, Xue Zhou, Jiangning Hu, Peiyi Wang, Ming Cai, Kai Yang, Peilong Sun, Xianguo Zou","doi":"10.1002/mnfr.70024","DOIUrl":"https://doi.org/10.1002/mnfr.70024","url":null,"abstract":"Scope: Gallic acid (GA) is recognized for its purported antiinflammatory properties. GA has been demonstrated to prevent and alleviate the symptoms of chronic colitis through the modulation of the gut microbiota, improvement of the intestinal barrier, and reduction of inflammation.Methods and results: In order to determine the mechanism by which GA exerts its protective effect against chronic colitis, mice were induced by dextran sulfate sodium (DSS). The reduction in the disease activity index by 25% and the decrease in colon tissue damage indicated that 36 days of GA intervention alleviated chronic DSS‐induced colitis symptoms. GA was observed to mitigate weight loss by 2.5% and the shortening of colon by 17.3%, and to diminish the expression of pivotal proteins within the TLR4/nuclear factor κB (NF‐κB) signaling cascades, consequently lowering the generation of inflammatory cytokines. Furthermore, GA effectively corrected the gut microbiota imbalance, increased the content of short‐chain fatty acids (SCFAs), which in turn suppressed inflammation, and enhanced tight junction protein expression, thereby strengthening the intestinal barrier. Conclusion: GA has the capacity to enhance the efficacy of chronic colitis through a multifaceted mechanism, influencing the gut microbiota, intestinal barrier function, and inflammatory processes. The findings highlight the potential of GA as a preventative strategy for chronic colitis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"11 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aged Garlic Extract Attenuates CaCl2-Induced Abdominal Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase 9 Expression in Macrophages

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-23 DOI: 10.1002/mnfr.70028

Kohei Karasaki, Mari Ishida, Hiroki Kokubo, Chiemi Sakai, Yusuke Kobayashi, Masao Yoshizumi

{"title":"Aged Garlic Extract Attenuates CaCl2-Induced Abdominal Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase 9 Expression in Macrophages","authors":"Kohei Karasaki, Mari Ishida, Hiroki Kokubo, Chiemi Sakai, Yusuke Kobayashi, Masao Yoshizumi","doi":"10.1002/mnfr.70028","DOIUrl":"https://doi.org/10.1002/mnfr.70028","url":null,"abstract":"Abdominal aortic aneurysm (AAA) is a local enlargement of the abdominal aorta with the risk of its fatal rupture. With lack of established medical treatments reducing the AAA growth, the development of treatment strategies for AAA is warranted. In this study, we examined whether aged garlic extract (AGE), which reportedly has vasoprotective effects, attenuates AAA formation in an animal model. AAAs were induced via CaCl2 application to the abdominal aortas of C57BL/6J mice. The intake of an AGE-containing diet attenuated the aortic dilatation after AAA induction. Histological analysis showed that the degradation of elastic fibers in AAAs was mild in mice fed AGE compared to that in control mice. In addition, the expression of matrix metalloproteinase 9 (MMP9), a proteolytic enzyme degrading aortic tissue, was decreased in AAAs from mice fed with AGE. In cultured macrophages, AGE significantly inhibited tumor necrosis factor (TNF)-α-induced Mmp9 mRNA expression. Furthermore, AGE attenuated TNF-α-induced extracellular signal-regulated kinase (ERK) phosphorylation and c-fos mRNA expression, suggesting the suppressive effect of AGE on ERK-c-Fos-MMP9 axis induced by TNF-α. The present findings indicate that AGE diminishes AAA formation by mitigating tissue destruction, highlighting the potential cardiovascular benefits of AGE intake.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"16 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143678298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arecoline Alleviates T2DM via Gut Microbiota Modulation and Liver Gene Regulation in Mice

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-23 DOI: 10.1002/mnfr.70015

Meng Xu, Wanggao Li, Yuan Xu, Jiachao Zhang, Hui Xue, Juan Du, Xiaosong Hu

引用次数: 0

Vitamin A-Enriched Diet Increases Urothelial Cell Proliferation by Upregulating Itga3 and Areg After Cyclophosphamide-Induced Injury in Mice

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-22 DOI: 10.1002/mnfr.70045

Brina Dragar, Simona Kranjc Brezar, Maja Čemažar, Tanja Jesenko, Rok Romih, Mateja Erdani Kreft, Tadeja Kuret, Daša Zupančič

{"title":"Vitamin A-Enriched Diet Increases Urothelial Cell Proliferation by Upregulating Itga3 and Areg After Cyclophosphamide-Induced Injury in Mice","authors":"Brina Dragar, Simona Kranjc Brezar, Maja Čemažar, Tanja Jesenko, Rok Romih, Mateja Erdani Kreft, Tadeja Kuret, Daša Zupančič","doi":"10.1002/mnfr.70045","DOIUrl":"https://doi.org/10.1002/mnfr.70045","url":null,"abstract":"Vitamin A (VitA) is an essential nutrient, affecting many cell functions, such as proliferation, apoptosis, and differentiation, all of which are important for the regeneration of various tissues. In this study, we investigated the effects of a VitA-enriched diet on the regeneration of the urothelium of the urinary bladder in mice after cyclophosphamide (CP)-induced injury. Female mice were fed VitA-enriched and normal diet for 1 week before receiving an intraperitoneal injection of CP (150 mg/kg). Urinary bladders were removed 1 and 3 days after CP. On Day 1, RNA sequencing showed that VitA upregulated two Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways: the cell cycle and the PI3K-Akt pathway. This was confirmed by qPCR, which showed significantly increased expression of the Itga3 and Areg genes. In addition, the effect of VitA on the proliferation of urothelial cells was analyzed by immunohistochemistry of Ki-67, which confirmed an increased proliferation rate. No significant effects of the VitA-enriched diet were observed on the expression of apoptosis-related genes and on differentiation-related markers of superficial urothelial cells. Our results suggest that a VitA-enriched diet improves early urothelial regeneration after CP-induced injury by promoting cell proliferation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"93 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Coenzyme Q10 Supplement Use and Associations With All-Cause and Cardiovascular Mortality: A Population-Based Cohort Study 辅酶 Q10 补充剂的使用趋势及其与全因死亡率和心血管死亡率的关系：基于人群的队列研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-21 DOI: 10.1002/mnfr.70019

Lihan Liang, Zepei Zhong, Zezhong Tian, Zhihao Liu, Huiying Kuang, Fang He, Ruijie Wang, Shanshan Hou, Yan Yang

{"title":"Trends in Coenzyme Q10 Supplement Use and Associations With All-Cause and Cardiovascular Mortality: A Population-Based Cohort Study","authors":"Lihan Liang, Zepei Zhong, Zezhong Tian, Zhihao Liu, Huiying Kuang, Fang He, Ruijie Wang, Shanshan Hou, Yan Yang","doi":"10.1002/mnfr.70019","DOIUrl":"https://doi.org/10.1002/mnfr.70019","url":null,"abstract":"Coenzyme Q10 (CoQ10) is a fat-soluble nutrient, which has antioxidant and anti-inflammatory properties. However, there is insufficient evidence on its daily use and the association with mortality. We aimed to evaluate the trends of CoQ10 supplement use among US noninstitutionalized adults and explore its associations with all-cause and CVD mortality. A prospective cohort study used data from the National Health and Nutrition Examination Survey (1999–2018). The association of CoQ10 supplementation with mortality was assessed with Cox proportional hazard models. The overall reported prevalence of CoQ10 supplement use increased from 1.2% (95% CI 0.7%–1.8%) in 1999–2000 to 4.6% (95% CI 3.4%–6.1%) in 2017–2018 (linear p = 0.002). During an average of 9.8 years of follow-up, 5237 deaths were identified, including 1428 deaths due to CVD. In the multivariable model, CoQ10 supplement use was not associated with all-cause mortality (HR 1.00, 95% CI 0.77–1.30, p = 0.996) and CVD mortality (HR 1.30, 95% CI 0.89–1.90, p = 0.170). Subgroup analyses suggested that the use of CoQ10 supplements was associated with a higher all-cause mortality in obese participants (HR 1.45, 95% CI 1.01–2.08, p for interaction = 0.013). Although the prevalence of CoQ10 supplement use experienced continuous growth from 1999 to 2018 in the general adults of NHANES, CoQ10 supplementation was not associated with all-cause and CVD mortality.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0