Molecular Nutrition & Food Research最新文献_第2页

Issue Information: Mol. Nutr. Food Res. 9'26 发布信息：Mol. Nutr。Food Res. 9'26

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-28 DOI: 10.1002/mnfr.70488

引用次数: 0

Phagocytosis of Primary Human Macrophages is Elevated by Ex Vivo Supplementation with n‐3 PUFA 体外补充n‐3 PUFA可提高人原代巨噬细胞的吞噬能力

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-25 DOI: 10.1002/mnfr.70475

Rebecca Kirchhoff, Michel André Chromik, Nils Helge Schebb

{"title":"Phagocytosis of Primary Human Macrophages is Elevated by Ex Vivo Supplementation with n‐3 PUFA","authors":"Rebecca Kirchhoff, Michel André Chromik, Nils Helge Schebb","doi":"10.1002/mnfr.70475","DOIUrl":"https://doi.org/10.1002/mnfr.70475","url":null,"abstract":"Epidemiologic studies show that a high n‐3 polyunsaturated fatty acid (PUFA) status is beneficial for health and inflammatory diseases. However, results of nutrition studies investigating the impact of n‐3 PUFA intake on immune functions, such as phagocytosis are contradictory. In order to gain more insights into the role of n‐3 PUFAs on phagocytosis, we investigated the modulation of phagocytosis by n‐3 PUFAs and derived oxylipins in human macrophages. Using an established ex vivo supplementation strategy, primary human macrophages were supplemented with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). The PUFA pattern of the cells was shifted from a low n‐3 PUFA status towards a high n‐3 PUFA status. This was accompanied by a shift in the oxylipin pattern, reduced pro‐inflammatory prostaglandin levels, increased phagocytosis in the supplemented macrophages, and reduced inhibitory effect of PGE 2 on phagocytosis. However, when tested alone, n‐3 PUFA derived oxylipins did not impact phagocytosis. Under controlled conditions, an increased n‐3 PUFA status of macrophages resulted in an elevation of phagocytosis. Less formation of prostaglandins could contribute to this effect, whereas n‐3 PUFA derived oxylipins, particularly multihydroxy PUFAs, appear to have a limited impact on phagocytosis following n‐3 PUFA supplementation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"51 1","pages":"e70475"},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordycepin-Enriched Cordyceps militaris Extract ARA815 Induces Ferroptosis in Lung Cancer Cells In Vivo and In Vitro 富虫草素的蛹虫草提取物ARA815诱导肺癌细胞体内外铁下垂

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-25 DOI: 10.1002/mnfr.70477

Mina Boo, Jae Heon Sim, HyoJeong Kim, Harim Kim, Hyunyoung Choi, Suhyeon An, HyunSoo Yang, Dong-Hyun Youn, Mingxiao Yang, Su Jin Park, Yohan Han, Ji Hoon Jung, Woojin Kim, Kwan-Il Kim, Kyungjin Lee, Hye-Lin Kim, Hyo In Kim, Jinbong Park

{"title":"Cordycepin-Enriched Cordyceps militaris Extract ARA815 Induces Ferroptosis in Lung Cancer Cells In Vivo and In Vitro","authors":"Mina Boo, Jae Heon Sim, HyoJeong Kim, Harim Kim, Hyunyoung Choi, Suhyeon An, HyunSoo Yang, Dong-Hyun Youn, Mingxiao Yang, Su Jin Park, Yohan Han, Ji Hoon Jung, Woojin Kim, Kwan-Il Kim, Kyungjin Lee, Hye-Lin Kim, Hyo In Kim, Jinbong Park","doi":"10.1002/mnfr.70477","DOIUrl":"https://doi.org/10.1002/mnfr.70477","url":null,"abstract":"Cordyceps militaris, a traditional medicinal fungus and a promising food supplement, has demonstrated anticancer potential, yet its underlying mechanisms and in vivo efficacy remain poorly defined. Previously, we developed an optimized extraction and preparation protocol to enrich the bioactive content of C. militaris, specifically adenosine and cordycepin. Here, using this optimized C. militaris extract (CME), we investigated its antitumor effects and underlying mechanisms in a murine lung cancer model. Components of CME were quantified using high-performance liquid chromatography. In vivo, CME significantly suppressed tumor growth in LLC1-bearing mice. Mechanistically, CME induced ferroptosis, an iron-dependent form of regulated cell death characterized by lipid peroxidation and redox imbalance. Tumors from CME-treated mice displayed elevated lipid ROS, increased iron accumulation, glutathione depletion, and downregulation of glutathione peroxidase 4. Apoptotic signaling was accompanied with ferroptosis, but neither pyroptosis nor necroptosis contributed to CME-induced lung cancer death. Pharmacological rescue experiments confirmed the specificity of ferroptosis as the dominant mode of cell death. Importantly, CME caused no systemic toxicity, and its approximate lethal dose was over 5000 mg/kg. Together, these findings suggest CME as a potent ferroptosis-inducing agent against lung cancer and establish C. militaris as a promising candidate for redox-targeted cancer therapy.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"19 1","pages":"e70477"},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micronutrients in Future Diets: Considerations for Dietary Iron and the Food Matrix Effects on Bioavailability 未来膳食中的微量营养素：考虑膳食铁和食物基质对生物利用度的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-25 DOI: 10.1002/mnfr.70483

Prachi Punetha, Tom F. O'Callaghan, Elaine K. McCarthy

{"title":"Micronutrients in Future Diets: Considerations for Dietary Iron and the Food Matrix Effects on Bioavailability","authors":"Prachi Punetha, Tom F. O'Callaghan, Elaine K. McCarthy","doi":"10.1002/mnfr.70483","DOIUrl":"https://doi.org/10.1002/mnfr.70483","url":null,"abstract":"Adequate nutrition is an essential contributor to improved health, longevity, and quality of life in the population. The shift toward sustainable, plant‐based diets is driving trends for the development and adaptation of more plant‐based food ingredients in future diets. With this, nutrient bioavailability, particularly of iron, remains a critical consideration. Iron deficiency remains a global public health challenge, particularly amongst women, pregnant women, and young children. One major contributor to iron deficiency is inadequate dietary iron intakes, but there are other factors that hinder the body's ability to absorb and utilize iron effectively. Dietary iron comes in two forms: heme, found in animal products and absorbed more efficiently, and non‐heme, found in plant‐based foods and is less readily absorbed. The absorption of non‐heme iron is influenced by various dietary components, which can act as inhibitors or promoters. Optimising food and ingredient formulations accounting for the food matrix and potential impacts on iron bioavailability can support nutritional adequacy and warrants consideration to ensure future foods are both healthy and sustainable.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"25 1","pages":"e70483"},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications 多酚在调节骨骼肌发育和体内平衡中的作用：分子机制和潜在的医学应用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-25 DOI: 10.1002/mnfr.70476

Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci

{"title":"The Role of Polyphenols in Regulating Skeletal Muscle Development and Homeostasis: Molecular Mechanisms and Potential Medical Applications","authors":"Roberto Mattioli, Daniel Di Risola, Carmen Chiaradia, Ivan Dimauro, Luciana Mosca, Guglielmo Duranti, Roberta Ceci","doi":"10.1002/mnfr.70476","DOIUrl":"https://doi.org/10.1002/mnfr.70476","url":null,"abstract":"A healthy lifestyle, characterized by moderate physical activity, appropriate caloric intake, and a diet rich in fruits and vegetables, contributes to maintaining overall health and preventing several degenerative diseases. Within this context, the health of the muscular system also plays a pivotal role. Increasing evidence highlights the importance of a balanced diet, in combination with regular physical exercise, in preserving muscle function and integrity. Polyphenols, present in fruits, vegetables, and plant-derived foods, have emerged as key allies in counteracting oxidative stress and inflammation, processes that affect muscle cell health. These compounds are involved in the regulation of muscle cell development and differentiation, as well as in the regeneration processes following injury or excessive physical exertion. Through their ability to modulate reactive oxygen species levels, inflammation, and specific cellular pathways, polyphenols are capable of influencing muscle development and homeostasis. This review provides a comprehensive overview of current knowledge regarding the impact of polyphenols on skeletal muscle growth, development, and maintenance, with a focus on their mechanisms of action and therapeutic potential. Recent and innovative extraction and administration strategies, aimed at overcoming some limitations that normally characterize experimentation with bioactive molecules such as polyphenols, are considered and discussed in a prospective view.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"26 1","pages":"e70476"},"PeriodicalIF":5.2,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Restricted Feeding Alters Behavior in a Sex-Specific Manner in Mice With Neuropathic Pain 限时进食改变了神经性疼痛小鼠的性别特异性行为

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-24 DOI: 10.1002/mnfr.70479

Manqing Wen, Wenjing Dai, Eija Kalso, Vinko Palada

{"title":"Time-Restricted Feeding Alters Behavior in a Sex-Specific Manner in Mice With Neuropathic Pain","authors":"Manqing Wen, Wenjing Dai, Eija Kalso, Vinko Palada","doi":"10.1002/mnfr.70479","DOIUrl":"https://doi.org/10.1002/mnfr.70479","url":null,"abstract":"Evidence suggests that neuropathic pain (NP) and comorbid mood disorders are associated with circadian abnormalities. This suggests a role for chronotherapies, such as time-restricted feeding (TRF), to alleviate pain and comorbid anxiety. We investigated the effects of TRF on pain and anxiety-related behaviours in spared nerve injury (SNI) mice with NP and diurnal changes in the hypothalamus transcriptome, an important hub for modulating fear and anxiety. SNI male and female C57BL/6JRj mice received TRF during the dark active phase or ad libitum feeding (ALF) for three weeks post-surgery. Behavioral tests, von Frey, hot plate, light-dark box (LDT), and open field (OFT), were performed at baseline and post-surgery; hypothalamus tissues were dissected in the morning (zeitgeber time (ZT) 2–6) and afternoon (ZT 8–12). Male, but not female, SNI mice under TRF showed significantly reduced anxiety-like behaviors (LDT: p = 0.0259, Cohen's d = 1.245; OFT: p = 0.0054, Cohen's d = 1.643). Differentially expressed gene (DEG) analysis identified 33 DEGs in the hypothalamus in male SNI mice between TRF and ALF in the afternoon, with enriched anxiety-related, mitochondrial, and circadian genes. These findings support TRF as a potential therapeutic approach to alleviate comorbid anxiety in NP.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"149 1","pages":"e70479"},"PeriodicalIF":5.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Fermented Soy Extract on Osteoporotic Changes in Ovariectomized Mice as a Model of Menopause 发酵大豆提取物对绝经模型去卵巢小鼠骨质疏松变化的治疗作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-24 DOI: 10.1002/mnfr.70480

Nisansala Chandimali, Seon Gyeong Bak, Seong-Min Hong, Ji Young Hwang, Hyuck Se Kwon, Jaehoon Bae, Sun Hee Cheong, Seung-Jae Lee

引用次数: 0

Dietary Compounds Drive Epigenetic Regulation and Modifications in Blood Cancer: A Critical Review 饮食化合物驱动表观遗传调控和改变在血癌：一个重要的回顾

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-24 DOI: 10.1002/mnfr.70471

Farhan Ikhtiar, Adil Jamal, Shumaila Kiran, Md. Belal Hossain

{"title":"Dietary Compounds Drive Epigenetic Regulation and Modifications in Blood Cancer: A Critical Review","authors":"Farhan Ikhtiar, Adil Jamal, Shumaila Kiran, Md. Belal Hossain","doi":"10.1002/mnfr.70471","DOIUrl":"https://doi.org/10.1002/mnfr.70471","url":null,"abstract":"Blood cancers, including leukemia, lymphoma, and myeloma, are complex malignancies influenced by genetic, environmental, and epigenetic factors. Among these, epigenetic modifications play a crucial role in cancer initiation and progression. This review explores the interplay between dietary patterns, epigenetic mechanisms, and blood cancer development, highlighting the potential of diet-based interventions in cancer prevention and therapy. A growing body of evidence suggests that dietary habits significantly impact epigenetic modifications such as DNA methylation and histone modifications, which regulate gene expression. Phytochemicals, including curcumin, resveratrol, quercetin, and epigallocatechin gallate (EGCG), exhibit promising epigenetic modulation in blood cancer. These compounds influence DNA methyltransferases (DNMTs) and histone deacetylases (HDACs), restoring normal epigenetic patterns and reactivating silenced tumor suppressor genes (TSGs). Individual variability in dietary response, bioavailability of bioactive compounds, and the complexity of epigenetic interactions necessitate further research in nutri-epigenomics. Future directions should focus on personalized nutrition strategies and clinical trials to validate the efficacy of dietary approaches in blood cancer prevention and therapy. In conclusion, diet plays a pivotal role in epigenetic regulation, influencing the risk and progression of blood cancer. Understanding the molecular mechanisms underlying dietary epigenetic modifications may open new avenues for preventive and therapeutic strategies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"19 1","pages":"e70471"},"PeriodicalIF":5.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147739201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulated Gastric Digestion of Calafate (Berberis microphylla) Berry Enhances Phenolic Bioaccessibility and Bioactivity Against Gastric Adenocarcinoma 小叶小檗酸浆果模拟胃消化提高酚类生物可及性和抗胃腺癌生物活性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-20 DOI: 10.1002/mnfr.70448

Bárbara Alarcón-Zapata, Maximiliano Ramm, Juan Monsalves, Pedro Alarcón-Zapata, Milovan Acevedo, Felipe A. Zuñiga, Giuliano Bernal, Claudia Mardones, Luis Bustamante

{"title":"Simulated Gastric Digestion of Calafate (Berberis microphylla) Berry Enhances Phenolic Bioaccessibility and Bioactivity Against Gastric Adenocarcinoma","authors":"Bárbara Alarcón-Zapata, Maximiliano Ramm, Juan Monsalves, Pedro Alarcón-Zapata, Milovan Acevedo, Felipe A. Zuñiga, Giuliano Bernal, Claudia Mardones, Luis Bustamante","doi":"10.1002/mnfr.70448","DOIUrl":"https://doi.org/10.1002/mnfr.70448","url":null,"abstract":"Calafate (Berberis microphylla), a native berry of Chilean Patagonia, exhibits high antioxidant capacity due to its phenolic content. This study evaluates the effect of simulated gastric digestion on the bioaccessibility of phenolic compounds and their subsequent impact on the viability and migration of gastric adenocarcinoma cells. The composition was analyzed by spectrophotometric and chromatographic methods; antioxidant capacity was analyzed by ORAC and CUPRAC methods; and antitumoral properties were analyzed by cell viability and migration cell assays. Results showed that total phenolics and sugars increased during gastric digestion. Flavonols, hydroxycinnamic acids, and berberine content increased after gastric digestion by enzyme action, while anthocyanins showed moderate stability regardless of enzyme activity. CUPRAC antioxidant capacity increased post-digestion, while ORAC values remained stable. In vitro assays in AGS (gastric adenocarcinoma) and GES-1 (normal gastric epithelium) cell lines demonstrated that the digested extract did not compromise normal cell viability. However, they promoted negligible proliferation of AGS after 48 h of exposure to the digested extract but decreased cell migration, such as in the original extract. These findings suggest that gastric digestion enhances Calafate phenolic bioaccessibility, without compromising it's in vitro antimetastatic properties.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"40 1","pages":"e70448"},"PeriodicalIF":5.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipidomic Profiling Reveals Differential Behaviors of Individual Free Fatty Acids During Altered Metabolic States in Rats 脂质组学分析揭示了大鼠代谢状态改变过程中个体游离脂肪酸的差异行为

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-04-20 DOI: 10.1002/mnfr.70473

Youngtaek Oh, Tong Shen, Richard M. Watanabe, Oliver Fiehn, Jang H. Youn

{"title":"Lipidomic Profiling Reveals Differential Behaviors of Individual Free Fatty Acids During Altered Metabolic States in Rats","authors":"Youngtaek Oh, Tong Shen, Richard M. Watanabe, Oliver Fiehn, Jang H. Youn","doi":"10.1002/mnfr.70473","DOIUrl":"https://doi.org/10.1002/mnfr.70473","url":null,"abstract":"We used lipidomic analyses to investigate how individual free fatty acids (FFAs) behave differently in metabolic states altered by diet and by antibiotic treatment (ABX) that depletes gut bacteria. Wistar rats were fed either a low-fat or high-fat purified diet, or standard chow with or without antibiotics for two weeks (n = 8–10). Blood samples were then collected before and after meals. Individual FFAs were quantified and grouped based on distinct postprandial response patterns across dietary and treatment conditions. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), key ω-3 FFAs, exhibited postprandial shifts suggestive of suppressed adipocyte lipolysis following meals. Fatty acids in the high-fat diet (HFD) elevated postprandial FFA levels, masking the meal-induced suppression of lipolysis observed with chow or low-fat diet (LFD). Some FFAs, including medium-chain saturated species, remained unaffected by meals. We further evaluated the impact of diet and ABX on baseline (pre-meal) concentrations of FFAs. Certain FFAs were altered by purified diets compared to standard chow. Notably, EPA and DHA were selectively depleted under HFD conditions, likely due to enhanced catabolic activity. In conclusion, lipidomic profiling revealed divergent behaviors among individual FFAs, reflecting distinct metabolic processes and regulatory mechanisms under altered metabolic states.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"1 1","pages":"e70473"},"PeriodicalIF":5.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0