Molecular Nutrition & Food Research最新文献_第2页

Lipid-Based Nanosystems to Enhance the Bioaccessibility and Bioavailability of Algal Lipids 脂基纳米系统提高藻脂的生物可及性和生物利用度

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-10-07 DOI: 10.1002/mnfr.70611

Francisca Marques, M. Rosário Domingues, Miguel Ângelo Cerqueira

{"title":"Lipid-Based Nanosystems to Enhance the Bioaccessibility and Bioavailability of Algal Lipids","authors":"Francisca Marques, M. Rosário Domingues, Miguel Ângelo Cerqueira","doi":"10.1002/mnfr.70611","DOIUrl":"10.1002/mnfr.70611","url":null,"abstract":"<div>\u0000 \u0000 <p>Lipid-based nanosystems (LBNs) present a promising opportunity to harness algae-derived lipids for food and nutraceutical applications, addressing the growing consumer demand for natural and safe ingredients. Algal lipids have attracted increasing attention due to their sustainability and composition in bioactive lipids, particularly omega-3 and omega-6 polyunsaturated fatty acids and polar lipids. However, their poor aqueous solubility, susceptibility to oxidation, and variable bioaccessibility restrict their effective application in food systems. LBNs, including nanoliposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and self-nanoemulsifying systems, have been proposed to improve the delivery of algal lipids by improving their solubilization, protecting them from gastrointestinal degradation, and potentially enhancing their intestinal absorption. This review critically examines and integrates the available evidence from in vitro digestion models, cellular and ex vivo assays, as well as in vivo studies, to provide insights into how LBNs modulate bioaccessibility, intestinal absorption, bioavailability, and downstream biological activities of algal lipids. Key methodological limitations and knowledge gaps that currently hinder definitive conclusions are also discussed, with the aim of guiding future research toward more robust and translatable evidence in this field and to support the development and application of algal lipid-loaded nanosystems in functional foods, nutraceuticals, and clinical nutrition.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol-Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling 富含多酚的食物作为健康和可持续的策略：心理健康和代谢组学分析

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-10-07 DOI: 10.1002/mnfr.70624

María Lucía Gómez Nieto, Verónica Puertas-Martín, Susana Chamorro, Antonio Méndez-Guerrero, Inmaculada Álvarez-Acero, Claudia Balderas, Sonia de Pascual-Teresa

{"title":"Polyphenol-Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling","authors":"María Lucía Gómez Nieto, Verónica Puertas-Martín, Susana Chamorro, Antonio Méndez-Guerrero, Inmaculada Álvarez-Acero, Claudia Balderas, Sonia de Pascual-Teresa","doi":"10.1002/mnfr.70624","DOIUrl":"10.1002/mnfr.70624","url":null,"abstract":"<p>The so‑called demographic transition has increased the prevalence of chronic diseases in adults over 65, accompanied by a rise in anxiety and depression. This study aimed at investigating the effect of cocoa flavanols and red berries (RB) anthocyanins consumption on depression and anxiety, focusing on the potential of the urinary metabolomic profile in the search for early biomarkers of intake and effect. A randomized, double-blind, parallel-group, 12-week intervention involving 59 healthy volunteers was conducted. The three dietary groups consumed either 5 g/day of RB (<i>n</i> = 20); 2.5 g/day of polyphenol-rich cocoa powder (C) (<i>n</i> = 20) or 7.5 g/day of a combination of cocoa and red berries (RB+C) (<i>n</i> = 19). The Beck Depression Inventory-II (BDI-II) and State-Trait Anxiety Inventory (STAI) were used for emotional assessments. Targeted and untargeted metabolomic analyses were conducted on urine samples. Regular intake of RB significantly reduced state anxiety compared with C. 7-Methylxanthine and 3-methylxanthine confirmed cocoa intake. L-tryptophan, represents an essential metabolic precursor in serotonin biosynthesis. Among evaluated metabolites, <i>p</i>-cresol glucuronide, <i>p</i>-methylhippuric acid, and epicatechin sulfate emerged as key candidates associated with emotional outcomes. These findings support a potential role of dietary polyphenols in modulating the gut–brain axis in an aging population.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70624","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol in Microplastic- and Nanoplastic-Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions 白藜芦醇在微塑料和纳米塑料诱导的毒性：目前的证据，机制的见解和未来的方向

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-10-07 DOI: 10.1002/mnfr.70623

Samaneh Sepahi, Habibeh Mashayekhi-Sardoo, Adel Ghorani Azam, Sina Gerayli, Prashant Kesharwani, Amirhossein Sahebkar

{"title":"Resveratrol in Microplastic- and Nanoplastic-Induced Toxicity: Current Evidence, Mechanistic Insights, and Future Directions","authors":"Samaneh Sepahi, Habibeh Mashayekhi-Sardoo, Adel Ghorani Azam, Sina Gerayli, Prashant Kesharwani, Amirhossein Sahebkar","doi":"10.1002/mnfr.70623","DOIUrl":"10.1002/mnfr.70623","url":null,"abstract":"<div>\u0000 \u0000 <p>Microplastic (MP; MPs) and nanoplastic (NP; NPs) pollution poses a growing threat to global health. Their small size and large surface area facilitate ingestion, accumulation, and interactions with biological systems, leading to toxicity through oxidative stress, inflammation, mitochondrial dysfunction, and cell death. These effects may occur directly or through the release of adsorbed pollutants and plastic additives. Resveratrol (3,5,4′-trihydroxy-trans-stilbene; RV), a natural polyphenol found in grapes, berries, and peanuts, has attracted interest as a potential protective agent because of its antioxidant and anti-inflammatory properties. Its proposed protective effects against MP/NP toxicity involve modulation of key cellular signaling pathways, particularly nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappa B (NF-κB). RV may activate Nrf2 by disrupting its interaction with Kelch-like ECH-associated protein 1 (Keap1), thereby enhancing antioxidant defenses, including superoxide dismutase, catalase, and glutathione peroxidase, and reducing reactive oxygen species-mediated damage to lipids, proteins, and DNA. Concurrently, RV may suppress NF-κB-mediated inflammatory responses. However, current evidence is limited to a small number of preclinical studies, with no human studies available. These mechanisms remain largely hypothetical and require validation using standardized MP/NP exposure models.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidiabetic and Hepatoprotective Effects of Dried Custard Apple (Annona squamosa) Pulp in Streptozotocin–Nicotinamide-Induced Diabetic Rats 干果浆对链脲佐菌素-烟酰胺诱导的糖尿病大鼠的抗糖尿病和保肝作用

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-10-01 DOI: 10.1002/mnfr.70621

Arpit Shrivastava, Ramakrishna Kakarla, Abhishek Dutt Tripathi, Veena Paul, Sairam Krishnamurthy, Aparna Agarwal, Dipendra Kumar Mahato

{"title":"Antidiabetic and Hepatoprotective Effects of Dried Custard Apple (Annona squamosa) Pulp in Streptozotocin–Nicotinamide-Induced Diabetic Rats","authors":"Arpit Shrivastava, Ramakrishna Kakarla, Abhishek Dutt Tripathi, Veena Paul, Sairam Krishnamurthy, Aparna Agarwal, Dipendra Kumar Mahato","doi":"10.1002/mnfr.70621","DOIUrl":"10.1002/mnfr.70621","url":null,"abstract":"<div>\u0000 \u0000 <p>Diabetes mellitus (DM) is known to impair the quality of life. Natural products with high antidiabetic potential and fewer side effects have attracted considerable interest. Recently, investigations into plant materials for their antidiabetic properties have received greater attention. Therefore, in the current study, the dried pulp of custard apple (<i>Annona squamosa</i>) (AS) was investigated for its effects on Streptozotocin and nicotinamide (STZ–NA)-induced DM. The antidiabetic activity of AS was evaluated by measuring body weight, plasma glucose, plasma lipid levels, and liver glycogen content. The results show no alteration in glucose levels in normoglycemic rats. In contrast, the OGTT reduced glucose levels to 85.16 ± 3.19 mg/dL. There was a decrease in plasma total cholesterol, triglycerides (TGs), low-density lipoprotein, and very low-density lipoprotein (mg/dL) of 95.29 ± 4.07, 72.05 ± 1.20, 56.90 ± 3.26, 24.87 ± 4.26, and 11.38 ± 2.11, respectively, in diabetic rats. The AS treatment increased the high-density lipoprotein (35.80 ± 1.51 mg/dL), liver glycogen (21.65 ± 3.61 mg/g), and body weight (178.10 ± 5.81 g) in diabetic rats. AS also increased pancreatic enzyme levels while decreasing TBA-reactive substances in diabetic rats. <i>Annona squamosa</i> treatment reduced liver enzyme levels in diabetic rats. These findings suggest that dried AS pulp may improve diabetes by improving glucose, lipids, antioxidants, and liver enzymes.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149086011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant Responses to Dietary Supplementation With Non-Enriched and Selenium-Enriched Mushrooms and Selenized Yeast in Piglets 饲粮中添加非富硒蘑菇和富硒酵母对仔猪抗氧化的影响。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-30 DOI: 10.1002/mnfr.70609

Diene France de de Souza, Gabriel Cipriano Rocha, Dairon Pérez Fuentes, Lucas Eduardo Oliveira Porto, Pedro Vitoriano Oliveira, Marliane de Cássia Soares da Silva, Maria Catarina Megumi Kasuya, Maiane de Paula Alves, Monique Renon Eller

{"title":"Antioxidant Responses to Dietary Supplementation With Non-Enriched and Selenium-Enriched Mushrooms and Selenized Yeast in Piglets","authors":"Diene France de de Souza, Gabriel Cipriano Rocha, Dairon Pérez Fuentes, Lucas Eduardo Oliveira Porto, Pedro Vitoriano Oliveira, Marliane de Cássia Soares da Silva, Maria Catarina Megumi Kasuya, Maiane de Paula Alves, Monique Renon Eller","doi":"10.1002/mnfr.70609","DOIUrl":"10.1002/mnfr.70609","url":null,"abstract":"<p>Selenium plays an important role in antioxidant defense and metabolic regulation. This study evaluated the effects of dietary supplementation with non-enriched and selenium-enriched <i>Pleurotus ostreatus</i> mushrooms, as well as selenized yeast, on selenium deposition and antioxidant responses in piglets, a relevant model for human nutrition. Sixty-four weaned piglets were fed control or supplemented diets for 21 days. Growth performance was not affected, indicating that the treatments were well tolerated. Selenium was higher in the loin of the supplemented groups than in the control group, whereas selenium concentration in the liver showed a numerical, but nonsignificant, increase in supplemented groups (<i>p</i> = 0.08), and no differences were observed in the kidney. Hepatic antioxidant activity was differentially modulated by dietary treatments. Glutathione peroxidase activity increased in all supplemented groups, whereas catalase activity increased only in piglets receiving selenium-enriched mushroom or selenized yeast, and superoxide dismutase activity increased only in the selenium-enriched mushroom group. Nitrite levels were reduced in all supplemented groups, while plasma antioxidant parameters remained unchanged. These findings indicate that dietary supplementation modulated hepatic antioxidant responses, although the relative contributions of selenium enrichment and mushroom bioactive compounds could not be determined.</p><p><b>Trial Registration Number and Date of Registration</b>: 106/2018</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Gastrointestinal Digestion and Gut Fermentation of Atlantic Forest Fruit-Flavored Kombucha: Gut Microbiota Dynamics and Bioactive Compound Bioaccessibility 大西洋林果味康普茶的体外消化和肠道发酵：肠道菌群动态和生物活性化合物的生物可及性。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-30 DOI: 10.1002/mnfr.70620

Kawany de Faria Forato, Vinícius dos Santos Domingues, Eduardo Lolato, Silvia Turroni, Semeh Bejaoui, Federica D'Amico, Volker Behrends, Solidea Amadei, Asia Pizzi, Giselle Nobre Costa, Adele Costabile, Karla Bigetti Guergoletto

{"title":"In Vitro Gastrointestinal Digestion and Gut Fermentation of Atlantic Forest Fruit-Flavored Kombucha: Gut Microbiota Dynamics and Bioactive Compound Bioaccessibility","authors":"Kawany de Faria Forato, Vinícius dos Santos Domingues, Eduardo Lolato, Silvia Turroni, Semeh Bejaoui, Federica D'Amico, Volker Behrends, Solidea Amadei, Asia Pizzi, Giselle Nobre Costa, Adele Costabile, Karla Bigetti Guergoletto","doi":"10.1002/mnfr.70620","DOIUrl":"10.1002/mnfr.70620","url":null,"abstract":"<p>Fermented foods are sources of highly bioavailable nutrients and compounds with health benefits. This exploratory study evaluated compound bioaccessibility, microbial survival and the effects of kombucha with Atlantic Forest fruits (jaboticaba, grumixama, juçara) on gut microbiota in healthy individuals. Samples underwent simulated digestion and 24 h fermentation with human fecal microbiota. Microbiota composition was analyzed by 16S rRNA amplicon sequencing, and SCFAs and BCFA were quantified. Yeasts, acetic acid bacteria, and lactic acid bacteria remained viable after digestion. Flavored kombucha (FK) showed high antioxidant activity. After 24 h, SCFAs increased, particularly acetate in FK; natural kombucha showed moderate effects, while tea and commercial kombucha caused minimal changes. Time was a major driver of variation in alpha and beta diversity, with the former declining especially with FK. The main taxonomic shifts included an increase in <i>Enterobacteriaceae</i> and a reduction in some beneficial taxa, with formulation-dependent specific modulation.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sweetened Beverages and Pancreatic Cancer: Insights From Recent Epidemiological Data and Oncogenic Mechanisms 甜饮料和胰腺癌：来自最近流行病学数据和致癌机制的见解

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-28 DOI: 10.1002/mnfr.70617

Ha Thi Thao Mai, Nilufar Mirzaeva, Do Tung Dac, Tran Tin Nghia, Mai Anh Thi Nguyen, J. Luis Espinoza

{"title":"Sweetened Beverages and Pancreatic Cancer: Insights From Recent Epidemiological Data and Oncogenic Mechanisms","authors":"Ha Thi Thao Mai, Nilufar Mirzaeva, Do Tung Dac, Tran Tin Nghia, Mai Anh Thi Nguyen, J. Luis Espinoza","doi":"10.1002/mnfr.70617","DOIUrl":"https://doi.org/10.1002/mnfr.70617","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose of Review</h3>\u0000 \u0000 <p>Hyperglycemia and altered carbohydrate metabolism may promote pancreatic cancer cell survival and proliferation. This narrative review critically evaluates epidemiological evidence on whether sugar-sweetened beverage (SSB) consumption is associated with pancreatic cancer risk and examines potential biological mechanisms involving glucose and fructose metabolism, oncogenic KRAS signaling, and metabolic reprogramming. Recent Findings: Earlier pooled analyses and a 2019 meta-analysis found no significant overall association between SSB consumption and pancreatic cancer risk. However, three subsequent studies, including a large prospective cohort from Taiwan and case-control studies from the United States and Jordan, reported positive associations in selected high-consumption groups. Differences in beverage definitions, dietary assessment methods, residual confounding, and study populations complicate comparisons. Mechanistic studies provide biological plausibility, suggesting that glucose and fructose metabolism and KRAS-driven metabolic reprogramming may enhance glycolysis, anabolic metabolism, nutrient acquisition, and cancer cell survival. Summary: Evidence linking SSB consumption to pancreatic cancer remains inconsistent and insufficient to establish causality. Future research should standardize beverage definitions, distinguish SSBs from artificially sweetened beverages and fruit juices, use repeated dietary assessments, control metabolic and lifestyle confounders, include diverse populations, and integrate epidemiological data with metabolic and molecular biomarkers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effects of Bovine Colostrum and Tremella fuciformis Polysaccharide on Enhancing Antioxidant Capacity, Immunomodulation, and Gut Microbiota Regulation in Mice 牛初乳和银耳多糖增强小鼠抗氧化能力、免疫调节和肠道菌群调节的协同作用

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-28 DOI: 10.1002/mnfr.70604

Yuhao Huang, Qinggang Xie, Qiqi Ren, Zhenxing Li

{"title":"Synergistic Effects of Bovine Colostrum and Tremella fuciformis Polysaccharide on Enhancing Antioxidant Capacity, Immunomodulation, and Gut Microbiota Regulation in Mice","authors":"Yuhao Huang, Qinggang Xie, Qiqi Ren, Zhenxing Li","doi":"10.1002/mnfr.70604","DOIUrl":"https://doi.org/10.1002/mnfr.70604","url":null,"abstract":"<div>\u0000 \u0000 <p>Bovine colostrum and <i>Tremella fuciformis</i> polysaccharide (TEP) exhibit bioactivities when used individually. However, the efficacy of their combined application remains unclear. Therefore, the present study aimed to investigate whether the co-administration of bovine colostrum and TEP exhibits synergistic effects in enhancing antioxidant capacity, immunomodulation, and gut microbiota regulation in mice. The results showed that TEP is composed of mannose, xylose, fucose, glucose, and glucuronic acid. The combined use of medium concentrations of bovine colostrum (125 mg/kg) and TEP (50 mg/kg) was exhibited serum MDA levels of 8.20 ± 0.54 nmoL/mL, GSH levels of 80.85 ± 3.12 µmoL/mL, and IgA levels of 13.46 ± 0.69 mg/mL, significantly outperforming the high-dose monotherapies (bovine colostrum 625 mg/kg or TEP 250 mg/kg). Besides, the combined use of medium concentrations of bovine colostrum and polysaccharide was significantly more effective than high concentrations of either substance alone in elevating serum levels of IgA, IgM, LZM, TNF-α, IL-6, and the gut abundance of <i>Bifidobacteriu</i>m and <i>Lactobacillus</i> of normal mice. These findings demonstrate that the combined use of bovine colostrum and TEP exhibits synergistic effects, which provide new insights for the formulation and development of dietary supplements and functional foods.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolization of Flavan-3-ol Oligomers by Eggerthella lenta, a Human Gut Bacterium 黄酮类-3-醇低聚物在人肠道细菌elgerthella lenta中的代谢

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-28 DOI: 10.1002/mnfr.70615

Ruben Halifa, Claire Dufour, Agnes Cornu, Philippe Ruiz, Jeanne Danon, Christian Ginies, Michel Dubourdeaux, Sophie Comtet-Marre, Pierre Peyret, Carine Le Bourvellec, Pascale Mosoni

{"title":"Metabolization of Flavan-3-ol Oligomers by Eggerthella lenta, a Human Gut Bacterium","authors":"Ruben Halifa, Claire Dufour, Agnes Cornu, Philippe Ruiz, Jeanne Danon, Christian Ginies, Michel Dubourdeaux, Sophie Comtet-Marre, Pierre Peyret, Carine Le Bourvellec, Pascale Mosoni","doi":"10.1002/mnfr.70615","DOIUrl":"https://doi.org/10.1002/mnfr.70615","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Flavan-3-ols are among the most widely consumed flavonoids and have been implicated in the prevention of cardiometabolic diseases. Increasing evidence indicates that phenolic metabolites produced by the gut microbiota from flavan-3-ols contribute significantly to these effects. While some bacterial species can metabolize flavan-3-ol monomers, no isolates with activity on oligomers, i.e., procyanidins, have been reported. Since the gut microbiota is known to hydrolyze procyanidins, our aim was to identify bacteria capable of degrading them and to characterize their resulting metabolites. Through culturomic, genomic, and metabolomic approaches, we isolated novel strains of <i>Eggerthella lenta</i> and <i>Flavonifractor plautii</i> that metabolize flavan-3-ol monomers. Their activity was subsequently tested on B-type (DP 2 to 4) and A-type (DP 2) procyanidins. Only <i>E. lenta</i> was able to convert procyanidins, whereas <i>F. plautii</i>, either alone or in co-culture with <i>E. lenta</i>, showed no detectable activity. The reaction catalyzed by <i>E. lenta</i> corresponded to C-ring opening of the terminal unit of the oligomers. This work provides the first demonstration of procyanidin metabolism by a human gut bacterium. The presence and activity of <i>E. lenta</i> in the gut may therefore be a key determinant of the health benefits associated with flavan-3-ol–rich diets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70615","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 19'26 发布信息：Mol. Nutr。Food Res. 2006年

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-28 DOI: 10.1002/mnfr.70622

引用次数: 0