Molecular Nutrition & Food Research最新文献_第3页

Research Progress of Panax notoginseng and Its Active Components in Preventing and Treating Cognitive Dysfunction of Aging. 三七及其有效成分防治衰老认知功能障碍的研究进展。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-14 DOI: 10.1002/mnfr.70216

Lan Sun,Fuyan Yang,Shanshan Wang,Jiarong Du,Rong Yuan,Bo Qiao,Yueying Wu,Xiaoya Li

引用次数: 0

Association Between Healthy Eating Index-2015 and the Risk of Parkinson's Disease in American Adults: A Cross-Sectional Study From NHANES 2003-2018. 美国成年人健康饮食指数-2015与帕金森病风险之间的关系：来自NHANES 2003-2018的横断面研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-14 DOI: 10.1002/mnfr.70258

Yanmei Cen,Xiaoyan Liu,Siqi Zhang,Yezi Xu,Lu Wang,Xiaoting Li,Zhaohao Zeng,Heng Meng

{"title":"Association Between Healthy Eating Index-2015 and the Risk of Parkinson's Disease in American Adults: A Cross-Sectional Study From NHANES 2003-2018.","authors":"Yanmei Cen,Xiaoyan Liu,Siqi Zhang,Yezi Xu,Lu Wang,Xiaoting Li,Zhaohao Zeng,Heng Meng","doi":"10.1002/mnfr.70258","DOIUrl":"https://doi.org/10.1002/mnfr.70258","url":null,"abstract":"Diet and nutrition significantly influence Parkinson's disease (PD) progression and risk reduction. The Healthy Eating Index 2015 (HEI-2015) effectively assesses diet quality. This study investigates the link between HEI-2015 scores and PD risk in the US population. We analyzed data from 80 241 National Health and Nutrition Examination Survey (NHANES) participants from 2003 to 2018 using weighted logistic regression and restricted cubic spline to explore non-linear links between HEI-2015 and PD risk. Subgroup analyses were conducted to assess variations influenced by confounding factors. After adjusting for potential confounders in both univariate and multivariate logistic regression models, individuals with PD had significantly lower HEI-2015 scores compared to those without PD. The restricted cubic spline (RCS) analysis found no non-linear relationship between HEI-2015 scores and PD risk. However, in our subgroup, individuals aged 50-60, females, non-Hispanic Whites, those with higher education and income, heavy alcohol consumers, and those without diabetes were notable. Enhancing the nutritional quality of one's diet could potentially lower the risk of PD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"24 1","pages":"e70258"},"PeriodicalIF":5.2,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake. 围产期摄入瘦素可预防年轻代谢性肥胖正常体重大鼠的认知障碍，海马转录组谱改变

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-13 DOI: 10.1002/mnfr.70262

Carmen García-Ruano,Andrea Costa,Andreu Palou,Paula Oliver

{"title":"Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake.","authors":"Carmen García-Ruano,Andrea Costa,Andreu Palou,Paula Oliver","doi":"10.1002/mnfr.70262","DOIUrl":"https://doi.org/10.1002/mnfr.70262","url":null,"abstract":"Early-life metabolic environment significantly impacts long-term cognitive and metabolic health. This study investigates transcriptomic alterations in the hippocampus and peripheral blood mononuclear cells (PBMC) of young rats exposed to an isocaloric high-fat diet (HFD), resulting in the metabolically obese, normal-weight (MONW) phenotype. Rats were pair-fed either a standard (NW group) or HFD (MONW group) for 11 weeks after weaning. Another group (MONW-Lep) received leptin supplementation during lactation and subsequently HFD. Transcriptomic analysis of the hippocampus showed disruption of pathways linked to obesity and cognitive decline in the MONW group, which were attenuated by leptin intake. This was consistent with the results of working memory (T-maze test), impaired in MONW versus NW, but preserved in MONW-Lep animals. PBMC transcriptomics revealed overlapping genes with the hippocampus. Notably, Piwil1, a gene linked to neurodegeneration, metabolic syndrome and obesity, was up-regulated in PBMC of MONW but not of MONW-Lep animals, reflecting early hippocampal changes and leptin's preventive effect. These findings highlight the influence of early nutrition on cognitive health, the protective potential of leptin counteracting the effects of HFD intake and the usefulness of PBMC as a reliable source of biomarkers of brain health.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"77 1","pages":"e70262"},"PeriodicalIF":5.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Biology-Based Heterologous Expression and Purification of Enterocin A: Advancing Antimicrobial Peptide Applications. 基于合成生物学的肠肽A的异种表达和纯化：推进抗菌肽的应用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-12 DOI: 10.1002/mnfr.70260

Mohamed Merzoug,Zohra Yasmine Zater,Khédidja Mosbahi,Daniel Walker,Svetoslav Dimitrov Todorov,Djamal Saidi

{"title":"Synthetic Biology-Based Heterologous Expression and Purification of Enterocin A: Advancing Antimicrobial Peptide Applications.","authors":"Mohamed Merzoug,Zohra Yasmine Zater,Khédidja Mosbahi,Daniel Walker,Svetoslav Dimitrov Todorov,Djamal Saidi","doi":"10.1002/mnfr.70260","DOIUrl":"https://doi.org/10.1002/mnfr.70260","url":null,"abstract":"Antibiotic resistance is a global health challenge, requiring the development of alternative antimicrobial strategies where pathogens can be inhibited by safe antimicrobials with different modes of action and less possibilities for developing resistance. Bacteriocins, ribosomally synthesized antimicrobial peptides produced by lactic acid bacteria, have emerged as promising natural agents for food preservation and pathogen control. This study reports the design and synthesis of a complete genetic cassette encoding the mature form of enterocin A, a bacteriocin derived from Enterococcus faecium. The vector (pJ404-pEntApep), containing the synthetic entA gene, was entirely constructed de novo and included as functional regulatory elements along with an N-terminal His6-tag for efficient purification. The genetic construct was validated through PCR and followed a sequencing of the generated amplicon. Expression in Escherichia coli BL21 (DE3) under optimized conditions (28°C, 0.5 mM IPTG) resulted in production of recombinant leaderless enterocin A (EntA), primarily in the form of inclusion bodies. Solubilization using 6 M guanidine-HCl, followed by protein refolding, enabled efficient recovery. The refolded peptide was purified via Ni-NTA affinity chromatography, with recorded elution at 400 mM imidazole. The purified enterocin A demonstrated potent antimicrobial activity against multidrug-resistant pathogens, including Staphylococcus aureus subsp. aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853, Acinetobacter lwoffii GPE 3002, Micrococcus luteus GPE 3001, and Bacillus cereus GPE 3003, with minimum inhibitory concentration (MIC) values ranging from 27 to 109 µg/mL. This study establishes a robust and cost-effective method for producing bioactive bacteriocins from inclusion bodies, underscoring their potential as sustainable alternatives to conventional antibiotics and chemical preservatives.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"67 1","pages":"e70260"},"PeriodicalIF":5.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Application of a Large-Scale, Data-Driven Approach to Prioritize Compound-Targeted Conditions in the Nutraceutical Space: Case Study of QuercefitTM (Quercetin Phytosome) Toward Unbalanced Lipid Conditions in Metabolically Challenged Adults. 大规模、数据驱动的方法在营养保健领域优先考虑化合物靶向条件的应用：槲皮素植物体（QuercefitTM）对代谢障碍成人不平衡脂质状况的案例研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-12 DOI: 10.1002/mnfr.70253

Loukia Lili,Sheena Smith,Laura Kunces,Riva Antonella,Pietro Allegrini,Stefano Togni,Serena Tongiani,Nate Rickard,Benjamin Readhead,Stephen Phipps,Bodi Zhang

{"title":"An Application of a Large-Scale, Data-Driven Approach to Prioritize Compound-Targeted Conditions in the Nutraceutical Space: Case Study of QuercefitTM (Quercetin Phytosome) Toward Unbalanced Lipid Conditions in Metabolically Challenged Adults.","authors":"Loukia Lili,Sheena Smith,Laura Kunces,Riva Antonella,Pietro Allegrini,Stefano Togni,Serena Tongiani,Nate Rickard,Benjamin Readhead,Stephen Phipps,Bodi Zhang","doi":"10.1002/mnfr.70253","DOIUrl":"https://doi.org/10.1002/mnfr.70253","url":null,"abstract":"In preventive healthcare, the demand for systematic identification of wellness-promoting natural compounds is rising. Quercetin, a phenolic compound found in various fruits and vegetables, is known for its antioxidant and anti-inflammatory properties, improving lipid profiles and metabolic dysfunctions in conditions like Type 2 diabetes and NAFLD. This study applies a novel adaptation of an in-silico drug repurposing methodology to quercetin, analyzing a gene expression signature library of over 800 diseases and 30 quercetin-related conditions to prioritize molecular targets. Our findings revealed a strong computational link between quercetin and hypercholesterolemia. To validate this, we conducted a proof-of-concept clinical study using a high-bioaccessibility quercetin formulation (QuercefitTM) in healthy adults with borderline metabolic profiles, confirming health benefits. This study highlights quercetin's known potential in managing hypercholesterolemia and demonstrates the power of computational methods in advancing natural compound discovery and repositioning. The integration of in-silico predictions with human studies could pave the way for more precise or alternative use of bioactive compounds in dietary supplements.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"35 1","pages":"e70253"},"PeriodicalIF":5.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limosilactobacillus reuteri CCFM1388 Enhances Exercise Endurance by Modulating Intestinal Bile Acid Metabolism and Cholesterol Absorption. 罗伊氏乳酸杆菌CCFM1388通过调节肠道胆汁酸代谢和胆固醇吸收提高运动耐力。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-12 DOI: 10.1002/mnfr.70251

Xin Wen,Jun Wang,Jingge Sun,Zhiying Jin,Qing Li,Gang Wang,Jianxin Zhao,Zhi Wang,Peijun Tian

{"title":"Limosilactobacillus reuteri CCFM1388 Enhances Exercise Endurance by Modulating Intestinal Bile Acid Metabolism and Cholesterol Absorption.","authors":"Xin Wen,Jun Wang,Jingge Sun,Zhiying Jin,Qing Li,Gang Wang,Jianxin Zhao,Zhi Wang,Peijun Tian","doi":"10.1002/mnfr.70251","DOIUrl":"https://doi.org/10.1002/mnfr.70251","url":null,"abstract":"Although probiotics have been shown to enhance physical endurance, the underlying mechanisms remain unclear. This study investigates the effects of Limosilactobacillus reuteri Culture Collection of Food Microorganisms (CCFM)1388 on exercise endurance and its regulatory role in gut microbiota and host metabolism. A treadmill fatigue model in mice demonstrated that CCFM1388 significantly improved exercise endurance by modulating testosterone biosynthesis. CCFM1388 altered gut bacterial genera involved in bile acid metabolism, leading to changes in deoxycholic acid (DCA) and chenodeoxycholic acid (CDCA) levels. These bile acids downregulated Niemann-Pick C1-Like 1 (NPC1L1), reducing intestinal cholesterol absorption and increasing low-density lipoprotein cholesterol (LDL-C) levels, a precursor for testosterone synthesis. A randomized, placebo-controlled clinical trial further revealed that CCFM1388 supplementation significantly enhanced thigh muscle strength of rehabilitation inpatients undergoing exercise therapy, compared to those in the placebo group, accompanied by increased LDL-C and high-density lipoprotein cholesterol (HDL-C) levels, although no significant changes in testosterone were observed. These findings highlight the potential of CCFM1388 in improving exercise performance by modulating cholesterol metabolism, suggesting its nutritional relevance in enhancing physical endurance and muscle function.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"66 1","pages":"e70251"},"PeriodicalIF":5.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145036016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioavailability of Magnesium and Potassium Salts Used as Potential Substitutes for Sodium Chloride in Human Nutrition - A Review. 作为氯化钠潜在替代品的镁和钾盐在人体营养中的生物利用度综述。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-10 DOI: 10.1002/mnfr.70227

Ronja Merschmann,Carlotta Burgmer,Gunter P Eckert,Anika E Wagner

{"title":"Bioavailability of Magnesium and Potassium Salts Used as Potential Substitutes for Sodium Chloride in Human Nutrition - A Review.","authors":"Ronja Merschmann,Carlotta Burgmer,Gunter P Eckert,Anika E Wagner","doi":"10.1002/mnfr.70227","DOIUrl":"https://doi.org/10.1002/mnfr.70227","url":null,"abstract":"Hypertension represents a major risk factor for cardiovascular diseases. As a diet high in sodium chloride is associated with hypertension, so-called \"blood pressure salts\" are attracting increasing scientific interest. These are characterized by a partial replacement of sodium chloride by other salts, mainly potassium and magnesium compounds. The aim of this review is to evaluate the bioavailability of potassium and magnesium salts as dietary supplements and to identify potential sodium chloride substitutes. A literature search was conducted in the PubMed database using the PICO scheme. Randomized controlled trials in healthy adults investigating the bioavailability of defined potassium/magnesium salts were included. Potassium chloride and potassium citrate showed good bioavailability irrespective of the route of administration and dose. Magnesium citrate and magnesium chloride showed good bioavailability while magnesium oxide was poorly bioavailable. This may be partly due to its poor solubility in water. The results indicate that potassium chloride and potassium citrate as well as magnesium citrate and chloride are suitable for the use as salt substitutes and for increasing potassium and magnesium intake in addition to reducing sodium. Due to its poor water solubility and consequently low bioavailability magnesium oxide is less suitable.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"35 1","pages":"e70227"},"PeriodicalIF":5.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Consumption of Type 2 Resistant Starch and d-Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High-Fat Diet. 饮食中摄入2型抗性淀粉和d-Fagomine延缓高脂肪饮食雄性大鼠代谢紊乱的进展。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70230

Bernat Miralles-Pérez, Sara Ramos-Romero, María José Charpentier, Vanessa Sánchez-Martos, Àngels Fortuño-Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol-Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu

{"title":"Dietary Consumption of Type 2 Resistant Starch and d-Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High-Fat Diet.","authors":"Bernat Miralles-Pérez, Sara Ramos-Romero, María José Charpentier, Vanessa Sánchez-Martos, Àngels Fortuño-Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol-Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu","doi":"10.1002/mnfr.70230","DOIUrl":"https://doi.org/10.1002/mnfr.70230","url":null,"abstract":"High-fat (HF) diets contribute to obesity, insulin resistance, fatty liver, gut microbiota dysbiosis, oxidative stress, and low-grade chronic inflammation. This study evaluated the preventive effects of dietary Type 2 resistant starch (RS2) from high-amylose maize and low-dose d-fagomine (FG) from buckwheat on these metabolic disturbances. Male Wistar-Kyoto rats (9-10 weeks old) were assigned to four diet groups for 10 weeks: standard (STD) diet, HF diet (45% kcal from fat), HF + RS diet (15% RS2), and HF + FG diet (0.1% FG). Body characteristics, metabolic parameters, oxidative stress, gut microbiota, short-chain fatty acids (SCFAs), and eicosanoids were analyzed. Both HF + RS and HF + FG diets reduced perigonadal fat, plasma triacylglycerols, and oxidative stress. HF + RS diet improved glucose tolerance without significantly affecting insulin sensitivity, while HF + FG diet showed a tendency for improvement at later stages. Additionally, HF + RS diet showed greater beneficial effects on body weight and liver steatosis than HF + FG diet, likely due to gut microbiota and SCFA modulation. RS2 exerted stronger metabolic effects than FG under HF diet conditions, suggesting its greater potential in mitigating obesity-related complications. FG effects may require longer exposure to manifest.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70230"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Modeling of Heart Failure Risk Based on Dietary Antioxidants: A Machine Learning Approach. 基于膳食抗氧化剂的心力衰竭风险预测建模：一种机器学习方法。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70249

Hechao Zhao,Guanguo Shen,Wenjie Zhang,Yangyi Zhang,Xiaochi Wang,Xiaoying Chen,Yali Chen,Linyi Ye,Jingtao Liu,Jing Jiang,Yanhua Wang

{"title":"Predictive Modeling of Heart Failure Risk Based on Dietary Antioxidants: A Machine Learning Approach.","authors":"Hechao Zhao,Guanguo Shen,Wenjie Zhang,Yangyi Zhang,Xiaochi Wang,Xiaoying Chen,Yali Chen,Linyi Ye,Jingtao Liu,Jing Jiang,Yanhua Wang","doi":"10.1002/mnfr.70249","DOIUrl":"https://doi.org/10.1002/mnfr.70249","url":null,"abstract":"This study investigates the relationship between dietary antioxidants and heart failure (HF) risk using nationally representative National Health and Nutrition Examination Survey data (2005-2018). It aims to identify key dietary antioxidants and develop a machine-learning-based predictive model for HF. Among 9279 participants (434 HF cases), 44 dietary antioxidant variables were extracted from two 24-h dietary recalls. Variance inflation factor filtering, SMOTE balancing, and Boruta selection were applied. Six machine learning models-random forest, LightGBM, K-nearest neighbors (KNN), Naive Bayes, support vector machine (SVM), and Xtreme Gradient Boosting (XGBoost)-were trained with and without demographic/lifestyle covariates. WQS and Qg-comp regressions quantified joint antioxidant effects. XGBoost achieved the highest accuracy (0.965 adjusted, 0.963 unadjusted), F1 score (0.971), and PR-AUC (0.993). WQS showed a 20% lower HF odds per quartile increase in overall antioxidant intake (odds ratio [OR] = 0.80, 95% CI: 0.68-0.93). SHAP analysis of the XGBoost model ranked theobromine, lycopene, caffeine, calcium, vitamin B12, vitamin C, and vitamin B1 as top contributors. Higher intake of specific dietary antioxidants-particularly vitamin B6, folate, and lycopene-is significantly associated with reduced HF risk. The XGBoost model provides a robust, interpretable tool for individual-level HF prediction based on dietary antioxidant profiles, supporting evidence-based dietary strategies for HF prevention.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":"e70249"},"PeriodicalIF":5.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Administration of Epigallocatechin Gallate Prevents Air Pollution-Induced Acute Lung Injury in Mice Via the Induction of Antioxidants. 表没食子儿茶素没食子酸酯通过诱导抗氧化剂预防空气污染引起的小鼠急性肺损伤。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70259

Yui Uehara, Hitomi Mito, Ayano Shikata, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Kenta Aso, Masahiro Kawahara, Tomonori Unno, Ken-Ichiro Tanaka

{"title":"Oral Administration of Epigallocatechin Gallate Prevents Air Pollution-Induced Acute Lung Injury in Mice Via the Induction of Antioxidants.","authors":"Yui Uehara, Hitomi Mito, Ayano Shikata, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Kenta Aso, Masahiro Kawahara, Tomonori Unno, Ken-Ichiro Tanaka","doi":"10.1002/mnfr.70259","DOIUrl":"https://doi.org/10.1002/mnfr.70259","url":null,"abstract":"Health hazards caused by air pollutants are increasing worldwide (SDGs 3.9), but no established prevention methods exist. Recently, we showed that intraperitoneal administration of epigallocatechin gallate (EGCG) prevents air pollutant-induced acute lung injury. To establish EGCG ingestion as a preventive method, the efficacy of oral EGCG administration needs to be analyzed, as it is easier than that of intraperitoneal administration. Therefore, we analyzed the effects of oral EGCG administration and ad libitum consumption of an EGCG-containing diet in mice. The combination of 0.2% EGCG-containing diet and oral EGCG administration (200 mg/kg) significantly inhibited the urban aerosol (UA)-induced acute lung injury, although each treatment alone was ineffective. Specifically, compared with the UA group, the combination group showed 37.3% decrease in total cell count, 30.5% decrease in neutrophil count, 52.6% decrease in protein level, and 39.6% decrease in dsDNA level in the bronchoalveolar lavage fluid. This combination also significantly inhibited air pollutant-induced increases in proinflammatory cytokine and chemokine expression (e.g., tumor necrosis factor-α) and ROS production in mouse lungs. Moreover, this combination increased the expression of antioxidant factors, such as nuclear factor E2-related factor 2, in whole blood. Thus, this EGCG-based intervention combination limits UA-induced acute lung injury by increasing antioxidant expression. SUMMARY: The effects of a combination of EGCG-based interventions were analyzed. The combination prevented air pollutant-induced lung inflammatory responses. The combination suppressed air pollutant-induced ROS production in the lungs. The combination increased the expression of various antioxidants in whole blood.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70259"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0