Molecular Nutrition & Food Research最新文献_第3页

Consumption of Ultra-Processed Food and Risk of Non-Alcoholic Fatty Liver Disease: A Prospective Analysis of the Korean Genome and Epidemiology Study. 食用超加工食品与非酒精性脂肪性肝病的风险：韩国基因组和流行病学研究的前瞻性分析

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-09 DOI: 10.1002/mnfr.70099

Jialei Fu,Li-Juan Tan,Sangah Shin

{"title":"Consumption of Ultra-Processed Food and Risk of Non-Alcoholic Fatty Liver Disease: A Prospective Analysis of the Korean Genome and Epidemiology Study.","authors":"Jialei Fu,Li-Juan Tan,Sangah Shin","doi":"10.1002/mnfr.70099","DOIUrl":"https://doi.org/10.1002/mnfr.70099","url":null,"abstract":"The association between ultra-processed foods (UPFs) consumption and non-alcoholic fatty liver disease (NAFLD) remains unclear; therefore, we investigated the association between UPF consumption and the risk of NAFLD among Korean adults. This cohort study included 44 642 Korean adults aged 40-69 years, utilizing data from the Health Examinees database. UPF were categorized according to the NOVA classification system based on the degree of processing. A multivariable Cox proportional hazards model assessed the association between UPF consumption and NAFLD risk. Over a 4.2-year follow-up period, 1562 (3.5%) participants developed NAFLD. After adjusting for potential confounders, higher UPF consumption was associated with a 35% (6%, 71%) and 48% (19%, 86%) increased risk of NAFLD in men and women, respectively. Similar results were observed in both continuous and sensitivity analyses. Among the diverse UPF subtypes, ramen consumption showed the strongest adverse association with NAFLD risk in both men and women (hazard ratio = 2.05 [1.59, 2.65] in men; 1.80 [1.48, 2.19] in women). Our findings suggest that higher UPF consumption is linked to an increased risk of NAFLD. Further comprehensive investigations in a broader spectrum of populations are warranted to corroborate and fortify these results.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"22 1","pages":"e70099"},"PeriodicalIF":5.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lactobacillus reuteri (Limosilactobacillus reuteri) TISTR 2736 Supplementation Attenuates Vascular Injury and Oxidative Stress in Rats Fed a High‐Cholesterol Diet 补充罗伊氏乳杆菌（Limosilactobacillus reuteri） TISTR 2736减轻高胆固醇饮食大鼠血管损伤和氧化应激

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-08 DOI: 10.1002/mnfr.70094

Nutthaphong Phongnu, Pennapa Chonpathompikunlert, Siritham Singhtho, Tantima Kumlung, Sareeya Reungpatthanaphong, Suthkamol Suttikul, Sakara Tunsophon, Wachirawadee Malakul

{"title":"Lactobacillus reuteri (Limosilactobacillus reuteri) TISTR 2736 Supplementation Attenuates Vascular Injury and Oxidative Stress in Rats Fed a High‐Cholesterol Diet","authors":"Nutthaphong Phongnu, Pennapa Chonpathompikunlert, Siritham Singhtho, Tantima Kumlung, Sareeya Reungpatthanaphong, Suthkamol Suttikul, Sakara Tunsophon, Wachirawadee Malakul","doi":"10.1002/mnfr.70094","DOIUrl":"https://doi.org/10.1002/mnfr.70094","url":null,"abstract":"Hyperlipidemia and oxidative stress are significantly related to atherosclerotic cardiovascular disease. Probiotic supplements have been demonstrated to reduce hyperlipidemia and might minimize atherosclerotic risk. This study aimed to evaluate the therapeutic ability of Lactobacillus reuteri TISTR 2736 (LR) on vascular damage in high‐cholesterol diet (HCD)‐induced hyperlipidemic rats and elucidate their possible mechanisms. Male Sprague–Dawley rats received a standard diet or HCD, and LR (2 × 108 CFU/rat/day) was orally administered to HCD‐fed rats for 8 weeks. Compared to the HCD‐fed group, LR administration reduced serum levels of TC, TG, LDL, and endothelin‐1 but elevated levels of aortic nitric oxide and serum HDL. Additionally, LR reversed the HCD‐induced aortic histological changes. The protein levels of adhesion molecules (VCAM‐1 and ICAM‐1), lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1), NADPH oxidase subunits p47phox, eNOS monomer/dimer ratio, oxidative stress markers (4‐hydroxynonenal and 3‐nitrotyrosine), and pro‐inflammatory cytokines (TNF‐α and IL‐6) were decreased, while those of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1), and the activity of superoxide dismutase were increased in the aortas of LR‐treated rats. These findings suggest that LR supplementation ameliorates HCD‐induced vascular dysfunction and inflammation, possibly by lowering hyperlipidemia, suppressing ROS production, and increasing antioxidant enzyme activities.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"48 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143920047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Effects of Shrimp Oil Against Oxidative Stress in Chronic Cerebral Hypoperfusion Rats 虾油对慢性脑灌注不足大鼠氧化应激的神经保护作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-08 DOI: 10.1002/mnfr.70079

Jirakhamon Sengking, Phakkawat Thangwong, Pranglada Jearjaroen, Luckika Panthiya, Natchaphol Buamard, Soottawat Benjakul, Jiraporn Tocharus, Chainarong Tocharus

{"title":"Neuroprotective Effects of Shrimp Oil Against Oxidative Stress in Chronic Cerebral Hypoperfusion Rats","authors":"Jirakhamon Sengking, Phakkawat Thangwong, Pranglada Jearjaroen, Luckika Panthiya, Natchaphol Buamard, Soottawat Benjakul, Jiraporn Tocharus, Chainarong Tocharus","doi":"10.1002/mnfr.70079","DOIUrl":"https://doi.org/10.1002/mnfr.70079","url":null,"abstract":"Shrimp oil is rich in polyunsaturated fatty acids and astaxanthin, which possesses high antioxidant activity. This study aimed to investigate the impact of shrimp oil on protection of brain damage and improvement of neurological outcomes after chronic cerebral hypoperfusion (CCH). Male Wistar rats were subjected to occlusion of the bilateral common carotid arteries and were divided into six groups: sham‐operated, 2‐vessel occlusion (2VO), 2VO‐treated with shrimp oil at the dose of 130, 260, and 520 mg/mL, and 2VO‐treated with resveratrol. Shrimp oil or resveratrol was administered via oral gavage after surgery once a day for 4 weeks. Shrimp oil reduced the level of cerebral damage after CCH associated with lower oxidative stress as indicated by attenuation of the levels of malondialdehyde (MDA), reactive oxygen species (ROS), nitric oxide (NO), and 4‐hydroxynonenal (4‐HNE). The shrimp oil treatment also initiated the antioxidant‐mediated nuclear factor E2‐related factor 2 (Nrf2)/heme‐oxygenase (HO‐1) pathway, reduced the hyperphosphorylation of tau, reduced neuronal cell death, promoted synaptic plasticity, and consequently promoted cognitive function. Shrimp oil exhibited neuroprotective effects against CCH‐induced cognitive impairment, which could be partially mediated through regulation of oxidative stress and neuronal apoptosis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"65 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers. 富含燕麦和大米的低麸质饮食的比较——代谢障碍志愿者6周随机临床试验

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-07 DOI: 10.1002/mnfr.70076

Enni Mannila,Petrus Nuotio,Anni Kuosmanen,Suchetana De Storvik,Anna Kårlund,Aija Jukkara,Milla-Maria Tauriainen,Johanna Närväinen,Marjukka Kolehmainen,Kaisa M Linderborg

{"title":"Comparison of Low-Gluten Diets Rich in Oats or Rice-A 6-Week Randomized Clinical Trial With Metabolically Challenged Volunteers.","authors":"Enni Mannila,Petrus Nuotio,Anni Kuosmanen,Suchetana De Storvik,Anna Kårlund,Aija Jukkara,Milla-Maria Tauriainen,Johanna Närväinen,Marjukka Kolehmainen,Kaisa M Linderborg","doi":"10.1002/mnfr.70076","DOIUrl":"https://doi.org/10.1002/mnfr.70076","url":null,"abstract":"Low-gluten diets (LGD) are also widely followed by people not suffering from coeliac disease. This study compared oats and rice as the main cereal source of an LGD in metabolically challenged volunteers. Volunteers (n = 69) were randomly assigned to an LGD, which was either rich in oats or rice, for 6 weeks. Before and after the intervention, concentrations of total cholesterol, LDL-C, and HDL-C, triacylglycerols, free fatty acids, glucose, and insulin were measured from fasting plasma samples; the volunteers also completed 4-day food and stool records, as well as questionnaires related to perceived gastrointestinal discomfort (Gastrointestinal Symptom Rating Scale) and health (RAND-36). The intervention with oats resulted in a more substantial decrease in LDL-C (pgroup × time = 0.047), more frequently normal type stool (pgroup × time = 0.010), and bowel movements (pgroup × time = 0.038) than rice (group × time interaction). The rice group experienced more constipation symptoms (pgroup × time < 0.001) than the oat group, possibly due to a lower fiber intake (pgroup × time < 0.001). A greater waist circumference decrease was observed with rice than with oats (pgroup × time = 0.022). Our results suggest that oats improve both biochemical markers of cardiometabolic health and perceived gastrointestinal well-being compared to rice, thus being a crucial part of a nutritiously adequate LGD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"125 1","pages":"e70076"},"PeriodicalIF":5.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol Improves Unilateral Nephrectomy/Amikacin-Induced Oxidative Injury in Rat Kidney Tissue 白藜芦醇改善单侧肾切除术/阿米卡辛诱导的大鼠肾组织氧化损伤

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-06 DOI: 10.1002/mnfr.70093

Ocampo-Gallego Jhonnatan Styver, Pedroza-Escobar David, Castillo-Maldonado Irais, Novelo-Aguirre Ana Lucía, Lozano-Palomo Jorge Alejandro, García-Garza Rubén, Sharara-Núñez Alfonso Ibrahim, Delgadillo-Guzmán Dealmy

{"title":"Resveratrol Improves Unilateral Nephrectomy/Amikacin-Induced Oxidative Injury in Rat Kidney Tissue","authors":"Ocampo-Gallego Jhonnatan Styver, Pedroza-Escobar David, Castillo-Maldonado Irais, Novelo-Aguirre Ana Lucía, Lozano-Palomo Jorge Alejandro, García-Garza Rubén, Sharara-Núñez Alfonso Ibrahim, Delgadillo-Guzmán Dealmy","doi":"10.1002/mnfr.70093","DOIUrl":"https://doi.org/10.1002/mnfr.70093","url":null,"abstract":"Chronic kidney disease (CKD) is characterized by progressive loss of kidney function and irreversible structural changes. Both kidney donation and amikacin exhibit nephrotoxic effects; however, polyphenols like resveratrol are known for their nephroprotective properties due to antioxidant capabilities. This study investigates the protective effects of resveratrol in a renal injury model involving unilateral nephrectomy and amikacin in Wistar rats. Male Wistar rats (n = 25) were divided into following five groups: (1) vehicle control, (2) resveratrol control, (3) kidney damage (unilateral nephrectomy plus amikacin), (4) resveratrol post-treatment, and (5) resveratrol pre-treatment. Renal function was assessed through serum creatinine and urea measurements. Oxidative stress was evaluated via malondialdehyde (MDA) levels, while antioxidant status was determined through total antioxidant capacity (TAC). Tissue analysis employed H&E, PAS, and Van Giesons trichrome staining. Data analysis was conducted using ANOVA and Tukeys post-hoc test for parametric data and the Kruskal–Wallis test with Dunns post-hoc for non-parametric data, with significance set at p < 0.05. Resveratrol treatment significantly improved body weight, renal compensatory growth, and several biochemical parameters. These results indicate that resveratrol may represent a promising nutritional strategy for safeguarding kidney function and architecture in renal injury contexts.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"25 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143910792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial 补充8周乳酸双歧杆菌HN019对功能性便秘的影响：一项多中心、三盲、随机、安慰剂对照试验

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-05 DOI: 10.1002/mnfr.70081

Reeta Ala-Jaakkola, Sofia D. Forssten, Jing Cheng, Flavie Griffon, Isabelle Metreau, Yves Sturm, Jean-Michel Lecerf, Yves Donazzolo, Jouni Junnila, Anders Nordlund, Ashley Hibberd, Arthur C. Ouwehand, Alvin Ibarra

{"title":"Effect of an 8-Week Bifidobacterium lactis HN019 Supplementation on Functional Constipation: A Multi-Center, Triple-Blind, Randomized, Placebo-Controlled Trial","authors":"Reeta Ala-Jaakkola, Sofia D. Forssten, Jing Cheng, Flavie Griffon, Isabelle Metreau, Yves Sturm, Jean-Michel Lecerf, Yves Donazzolo, Jouni Junnila, Anders Nordlund, Ashley Hibberd, Arthur C. Ouwehand, Alvin Ibarra","doi":"10.1002/mnfr.70081","DOIUrl":"https://doi.org/10.1002/mnfr.70081","url":null,"abstract":"Functional constipation (FC) is characterized by difficult, infrequent, or incomplete bowel movements without clear physiological cause. Daily intake of Bifidobacterium lactis HN019 has been shown to reduce colonic transit time or increases bowel movement frequency in 2–4 weeks interventions. This triple-blind, randomized, placebo-controlled clinical trial assessed the effect of 8 weeks HN019 supplementation on complete spontaneous bowel movement (CSBMs) in adults with FC (diagnosed by Rome III criteria). Furthermore, stool consistency, degree of straining, abdominal pain severity, bloating severity, PAC-SYM, PAC-QoL, and use of rescue medication were assessed. Participants were screened at four clinical units in France for 2 weeks to confirm eligibility: no safety concerns, ≤3 CSBMs/week (recorded in daily diaries), followed by an 8-week intervention with daily supplementation of HN019 or placebo. HN019 was not found to be superior in managing FC compared to placebo. Fecal samples were collected from 50% of the participants for analyses of moisture content, microbiota, microbial metabolites, and calprotectin. These did not show any significant differences between the groups. This study did not support the expected effect of HN019 on improving CSBM frequency in participants with FC. No safety concerns related to B. lactis HN019 supplementation were identified.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"113 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulated Digestion and Fermentation of Polyphenols From Sargassum wightii Acts as Potential Modulator of Alzheimer's Disease 马尾藻多酚模拟消化发酵作为阿尔茨海默病的潜在调节剂

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-05 DOI: 10.1002/mnfr.70071

Anushree Gade, Maushmi S. Kumar

{"title":"Simulated Digestion and Fermentation of Polyphenols From Sargassum wightii Acts as Potential Modulator of Alzheimer's Disease","authors":"Anushree Gade, Maushmi S. Kumar","doi":"10.1002/mnfr.70071","DOIUrl":"https://doi.org/10.1002/mnfr.70071","url":null,"abstract":"The human gut microbiota regulates various aspects of Alzheimer's disease (AD) pathophysiology, influencing neuroinflammation and metabolic homeostasis. Dietary polyphenols, specifically phlorotannins from brown macroalgae, are known to mitigate AD's pathological effects due to their ability to pass through the blood–brain barrier. Marine polyphenols extracted from Sargassum wightii were processed through simulated gastrointestinal digestion and in vitro fermentation. Characterization was performed using ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR), HPLC, and liquid chromatography‐mass spectrometry/mass spectrometry (LC‐MS/MS) both before and after biotransformation. We evaluated their metal chelation capacity (Cu2⁺ and Fe2⁺) and acetylcholinesterase (AChE) inhibitory activity using colorimetric assays. Additionally, the antioxidant capacity of the polyphenol extract was evaluated before and upon fermentation using 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), 2,2′‐azinobis‐3‐ethylbenzothiazoline‐6‐sulfonic acid (ABTS), and ferric reducing antioxidant potential (FRAP) assays. The extraction yield of polyphenols from S. wightii was 2.67 ± 0.27 mg PGE/g of macroalgae. In vitro biotransformation of these polyphenols resulted in the formation of various low‐molecular weight (LMW) compounds with enhanced metal chelation and AChE inhibition activities. Additionally, a substantial rise in antioxidant activity was observed postbiotransformation. S. wightii polyphenols become more effective after biotransformation, with enhanced bioactive properties and promising for use in diets to prevent and manage AD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"75 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Adaptation of Non‐Heme Iron Absorption in Vegans: A Controlled Trial 素食者非血红素铁吸收的饮食适应性：一项对照试验

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-05 DOI: 10.1002/mnfr.70096

Miguel López‐Moreno, Isabel Viña, Paula Marrero‐Fernández, Carla Galiana, Gabriele Bertotti, Alberto Roldán‐Ruiz, Marta Garcés‐Rimón

{"title":"Dietary Adaptation of Non‐Heme Iron Absorption in Vegans: A Controlled Trial","authors":"Miguel López‐Moreno, Isabel Viña, Paula Marrero‐Fernández, Carla Galiana, Gabriele Bertotti, Alberto Roldán‐Ruiz, Marta Garcés‐Rimón","doi":"10.1002/mnfr.70096","DOIUrl":"https://doi.org/10.1002/mnfr.70096","url":null,"abstract":"Non‐heme iron, mainly from plant foods, is theoretically less bioavailable than heme iron from animal food, which might increase the risk of iron deficiency in vegans. This study aimed to evaluate acute changes in plasma iron levels following non‐heme iron intake in vegans compared with omnivores and to explore the mechanisms regulating these changes. Twenty‐seven participants (18–30 years old) were divided into vegans and omnivores. After baseline measurements (body composition, blood pressure, and blood biomarkers), the participants consumed 150 g of pistachios. Blood samples were taken at baseline, 120 and 150 min after consumption to measure serum iron. The main outcome was the area under the curve (AUC) of serum iron The AUC for serum iron was significantly higher in vegans (1002.8 ± 143.9 µmol/L/h) compared to omnivores (853 ± 268.2 µmol/L/h) (p = 0.04; ES: 0.68). Multivariate regression analysis identified significant associations with hepcidin levels (β = −0.5, p = 0.03) and basal iron levels in the vegan group. This study demonstrates higher non‐heme iron absorption in vegans compared to omnivores, highlighting the physiological adaptations involved in iron metabolism in plant‐based diets. Larger longitudinal studies are needed to confirm these findings and assess plant‐based diets' long‐term effects on iron metabolism.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"59 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Piperine on Indomethacin-Induced Intestinal Damage 胡椒碱对吲哚美辛致肠道损伤的保护作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-05 DOI: 10.1002/mnfr.70097

Karine Nader Gervasoni, Maria Vitória Minzoni De Souza Iacia, Kimberlly De Oliveira Silva, Letícia Gervasoni Franco, Maria Eduarda Ferraz Mendes, Thiago José Da Cruz Neves, William Silva Sanches, Lívia Batista Oliveira, Ellen Almeida Saito, Karolinny Cristiny De Oliveira Vieira, Valéria Cataneli Pereira, Gisele Alborghetti Nai, Lizziane Kretli Winkelstroter

{"title":"Protective Effect of Piperine on Indomethacin-Induced Intestinal Damage","authors":"Karine Nader Gervasoni, Maria Vitória Minzoni De Souza Iacia, Kimberlly De Oliveira Silva, Letícia Gervasoni Franco, Maria Eduarda Ferraz Mendes, Thiago José Da Cruz Neves, William Silva Sanches, Lívia Batista Oliveira, Ellen Almeida Saito, Karolinny Cristiny De Oliveira Vieira, Valéria Cataneli Pereira, Gisele Alborghetti Nai, Lizziane Kretli Winkelstroter","doi":"10.1002/mnfr.70097","DOIUrl":"https://doi.org/10.1002/mnfr.70097","url":null,"abstract":"Nonsteroidal antiinflammatory drugs (NSAIDs) are widely prescribed for the treatment of inflammation and chronic pain. Chronic use of NSAIDs is associated with adverse events and organ damage, especially to the gastric mucosa and small intestine. This study evaluates the protective effect of piperine on indomethacin-induced intestinal damage. Eighteen male Mus musculus mice, aged 6–8 weeks, were used. Intestinal damage was induced with indomethacin (10 mg/mL) and cotreatment with piperine (20 mg/mL), both administered orally. After 14 days, the animals were euthanized. Biochemical serological analysis was performed. Intestinal inflammation was assessed based on macroscopic, histopathological, and metagenomic analyses. Histopathological analysis showed a reduction in small intestine inflammation (p < 0.05) and the disappearance of necrosis in the intestinal wall of the large intestine. Crypt and villus measurements showed increased values in the piperine-treated group (p < 0.05). An approximately six-fold increase in aspartate aminotransferase (AST) was observed in the Indomethacin group (p < 0.05). Regarding the intestinal microbiota, an increase in genus diversity was observed in the piperine-treated group (p < 0.05). There was a 50% reduction in micronucleus formation with the administration of piperine 20 mg/kg (p < 0.05). It was concluded that cotreatment with piperine has great potential in mitigating the side effects caused by NSAIDs.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 9'25 发布信息：Mol. Nutr。Food Res. 9'25

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-05-04 DOI: 10.1002/mnfr.70086

引用次数: 0