Molecular Nutrition & Food Research最新文献_第3页

Protective Effects of Human Milk Oligosaccharides (hMOs) on Analgesic, Nonsteroidal Anti-inflammatory Drugs (NSAIDs)-Induced Disruption of Gut Barrier Integrity in Cocultures Mimicking Neuro-Gut Epithelial Cell Crosstalk. 人乳寡糖（hMOs）对镇痛、非甾体抗炎药（NSAIDs）诱导的模拟神经-肠道上皮细胞串扰共培养中肠道屏障完整性破坏的保护作用

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-23 DOI: 10.1002/mnfr.70146

Xiaochen Chen, Naschla Gasaly, Marthe T C Walvoort, Paul de Vos

{"title":"Protective Effects of Human Milk Oligosaccharides (hMOs) on Analgesic, Nonsteroidal Anti-inflammatory Drugs (NSAIDs)-Induced Disruption of Gut Barrier Integrity in Cocultures Mimicking Neuro-Gut Epithelial Cell Crosstalk.","authors":"Xiaochen Chen, Naschla Gasaly, Marthe T C Walvoort, Paul de Vos","doi":"10.1002/mnfr.70146","DOIUrl":"https://doi.org/10.1002/mnfr.70146","url":null,"abstract":"<p><p>Nonsteroidal anti-inflammatory drugs (NSAIDs) like indomethacin alter gut microbiota composition and disrupt intestinal integrity, increasing the risks of inflammatory bowel disease (IBD). Gut barrier function is regulated by a complex crosstalk between different cell types, including epithelial cells and cells from the enteric nervous system (ENS). Human milk oligosaccharides (hMOs), particularly 2'-fucosyllactose (2'-FL) and 3-fucosyllactose (3-FL), can regulate intestinal barrier function, but their roles in neuroepithelial crosstalk under NSAID stress remain unclear. This study focused on hMOs' direct epithelial effects to explore their potential in microbiota-independent effects caused by the NSAID indomethacin. T84 colorectal carcinoma cells were cocultured with SH-SY5Y neuroblastoma cells in ratios of 29:1 and 14:1. We evaluated the protective role of hMOs in indomethacin-induced barrier disruption. We found that indomethacin reduced transepithelial electrical resistance (TEER), disrupted F-actin organization, and decreased tight junction (TJ) protein expression. Pretreatment with 2'-FL and 3-FL protected against these effects, particularly in cocultures with a higher nerve cell ratio of 14:1, restoring TEER, F-actin integrity, and claudin-1 expression. These findings highlight the therapeutic potential of 2'-FL and 3-FL in directly maintaining barrier integrity in intestinal neuroepithelial cocultures during NSAID treatment.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70146"},"PeriodicalIF":4.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol Consumption Amount, Drinking Pattern, and the Trajectory of Multimorbidity: A Prospective Cohort Study 饮酒量、饮酒模式和多重发病轨迹：一项前瞻性队列研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-23 DOI: 10.1002/mnfr.70154

Weiqi Wang, Zhen Tian, Qiaoyu Wang, Qingrao Song, Yaxin Chen, Yuhua Song, Yuan Wang, Wanying Hou, Changhao Sun

{"title":"Alcohol Consumption Amount, Drinking Pattern, and the Trajectory of Multimorbidity: A Prospective Cohort Study","authors":"Weiqi Wang, Zhen Tian, Qiaoyu Wang, Qingrao Song, Yaxin Chen, Yuhua Song, Yuan Wang, Wanying Hou, Changhao Sun","doi":"10.1002/mnfr.70154","DOIUrl":"https://doi.org/10.1002/mnfr.70154","url":null,"abstract":"This study aimed to investigate the impacts of both alcohol consumption amount and drinking pattern on the progression from healthy to first noncommunicable disease (FNCD), subsequently to multimorbidity, and ultimately to death.We conducted this analysis in the UK Biobank cohort (N = 284 744). Multimorbidity was defined as the coexistence of at least two noncommunicable diseases, including cancer, chronic respiratory disease, cardiovascular disease, and Type 2 diabetes. Multistate model was used to estimate the impacts of alcohol consumption on the whole trajectory of multimorbidity.Guidelines harmful drinkers showed increased risks of all five transitions of multimorbidity than nondrinkers, with hazard ratios (95% CI) 1.16 (1.09, 1.23) and 1.10 (1.00, 1.22) for transitions from baseline to FNCD, and then to multimorbidity, and 1.40 (1.22, 1.61), 1.37 (1.23, 1.54), and 1.41 (1.19, 1.67) for transitions from baseline, FNCD, and multimorbidity to death. Similar associations were found for spirits and beer consumption, but not red wine. For drinking patterns, drinking without food was associated with higher risks of four transitions except death from multimorbidity than drinking with food.Our results indicate that both alcohol consumption amount and drinking pattern exert important effects on almost all phases of multimorbidity development.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"147 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postprandial Responses to Meals Enriched With Canola or Coconut Oil in Men and Women With a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial. 具有心脏代谢疾病风险表型的男性和女性对富含菜籽油或椰子油的膳食的餐后反应：一项随机交叉试验

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-19 DOI: 10.1002/mnfr.70147

Hannah F Kienēs,Christina Diekmann,Tim Schiemann,Carolin Wiechmann,Christina Kopp,Birgit Stoffel-Wagner,Martin Coenen,Robert Németh,Sarah Egert

{"title":"Postprandial Responses to Meals Enriched With Canola or Coconut Oil in Men and Women With a Risk Phenotype for Cardiometabolic Diseases: A Randomized Crossover Trial.","authors":"Hannah F Kienēs,Christina Diekmann,Tim Schiemann,Carolin Wiechmann,Christina Kopp,Birgit Stoffel-Wagner,Martin Coenen,Robert Németh,Sarah Egert","doi":"10.1002/mnfr.70147","DOIUrl":"https://doi.org/10.1002/mnfr.70147","url":null,"abstract":"We investigated the metabolic response to meals with canola or coconut oil (rich in unsaturated vs. rich in saturated fatty acids [FAs]). Although the longer-term metabolic effects of these fats are well evidenced, their postprandial effects remain inconclusive. In this randomized crossover trial, 29 participants with increased cardiometabolic risk consumed four isoenergetic meals containing 25 or 50 g (low-fat meals [LFMs], high-fat meals [HFMs]) of canola or coconut oil. Blood samples for analysis of triglycerides (TGs), glucose, insulin, nonesterified FAs (NEFAs), IL-6, and individual FAs were collected in the fasting state and 6 h postprandially (every 0.5-1 h). The incremental areas under the curves (iAUCs) of TGs and IL-6 were higher after canola than after coconut oil. Concentrations of lauric and myristic acid were higher after coconut oil, while concentrations of oleic, linoleic, and α-linolenic acid were higher after canola oil. The TG iAUC was higher after HFMs than after corresponding LFMs. NEFAs decreased more after LFMs than after HFMs. The glucose and insulin iAUCs were higher after LFMs than after HFMs. Canola and coconut oil induced different metabolic responses. The manner and strength of the postprandial effects differed depending on the parameter.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"46 1","pages":"e70147"},"PeriodicalIF":5.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study. 富含菠萝蛋白酶的菠萝提取物治疗小儿睾丸附睾炎：一项随机临床试验研究。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-19 DOI: 10.1002/mnfr.70148

Alessandro Colletti,Luciano Sangiorgio,Alma Martelli,Marzia Pellizzato,Giancarlo Cravotto

{"title":"Bromelain-Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study.","authors":"Alessandro Colletti,Luciano Sangiorgio,Alma Martelli,Marzia Pellizzato,Giancarlo Cravotto","doi":"10.1002/mnfr.70148","DOIUrl":"https://doi.org/10.1002/mnfr.70148","url":null,"abstract":"A freeze-dried pineapple extract-Brome-Inf, from pineapple by-products of industrial rings production, was enriched in bioactive polypeptides and bromelain by membrane ultrafiltration. Orchiepididymitis (OE), a painful pediatric pathology, was treated with this extract. A pilot, double-blind, randomized study involving 60 pediatric OE patients compared the effects of Brome-Inf to a placebo over a 15-day period, in conjunction with antibiotic treatment. In the present study, the primary objective was to assess the disparity in NSAIDs usage and pain intensity between the Brome-Inf group and the placebo group, utilizing the Wong-Becker, Numerical Rating Scale (NRS), and Visual Analogue Scale (VAS) pain rating scales. Results revealed a significant reduction in VAS and NRS within the Brome-Inf group from Days 1 to 15 compared with placebo. A rapid regression of edema was observed in the active group after 1 week and at the end of the study. We can conclude that oral supplementation with Brome-Inf emerges as a promising co-management option for OE for its action on pain and edema, potentially enhancing the quality of life for affected children. Importantly, due to its well-balanced fruity flavor, the palatability of Brome-Inf was appreciated, ensuring optimal patient compliance and treatment safety.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"24 1","pages":"e70148"},"PeriodicalIF":5.2,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grape Seed Proanthocyanidins: A Potential Microbiome-Targeted Intervention for Healthy Aging in Rats. 葡萄籽原花青素：一种潜在的微生物组靶向干预大鼠健康衰老。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-18 DOI: 10.1002/mnfr.70150

Marta Sierra-Cruz,Adrià Vilalta,Alba Miguéns-Gómez,Harry Park,Esther Rodríguez-Gallego,Maria Teresa Blay,Anna Ardévol,Montserrat Pinent,Jacques Behmoaras,Raúl Beltrán-Debón,Ximena Terra

{"title":"Grape Seed Proanthocyanidins: A Potential Microbiome-Targeted Intervention for Healthy Aging in Rats.","authors":"Marta Sierra-Cruz,Adrià Vilalta,Alba Miguéns-Gómez,Harry Park,Esther Rodríguez-Gallego,Maria Teresa Blay,Anna Ardévol,Montserrat Pinent,Jacques Behmoaras,Raúl Beltrán-Debón,Ximena Terra","doi":"10.1002/mnfr.70150","DOIUrl":"https://doi.org/10.1002/mnfr.70150","url":null,"abstract":"Aging and age-related metabolic complications are global health issues that pose a serious threat to public health. Gut dysfunction and dysbiosis contribute to age-related health decline. Grape seed-derived procyanidins (GSPE) have shown efficacy in mitigating adaptive homeostasis decline in young animal models, but their impact on intestinal health and the gut microbiome in aged animals remains unexplored. Twenty-one-month-old female rats were treated with 500 mg GSPE/kg of body weight for 10 days. After 11 weeks, GSPE anti-aging potential was evaluated by measuring plasma lipopolysaccharide, gut integrity gene expression, ex vivo gut barrier function, myeloperoxidase activity, and fecal microbiome composition. GSPE shifted the microbiota toward a younger profile, even restoring lost strains in aged rats. Despite the presence of metabolic aging markers, there was minimal deterioration in gut barrier function. Neither ex vivo permeability tests, transcriptional analysis of barrier function, nor gut histology showed significant impairment in gut. Only jejunal myeloperoxidase activity was increased in aged rats and reduced by GSPE. Intestinal barrier function showed mild deterioration in this model of aged rats. GSPE improved the aging process by modulating the gut microbiome, suggesting its potential as a microbiome-targeted intervention for promoting healthy aging.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"56 1","pages":"e70150"},"PeriodicalIF":5.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bottom-Up Design of Prebiotics and Probiotics: An Intestinal Microbiota-Centered Approach to Chronic and Functional Constipation Management. 益生元和益生菌的自下而上设计：以肠道微生物群为中心的慢性和功能性便秘管理方法。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-17 DOI: 10.1002/mnfr.70140

Penglin He,Shang Chen,Chenang Lyu,Ran An,Dapeng Wang

{"title":"Bottom-Up Design of Prebiotics and Probiotics: An Intestinal Microbiota-Centered Approach to Chronic and Functional Constipation Management.","authors":"Penglin He,Shang Chen,Chenang Lyu,Ran An,Dapeng Wang","doi":"10.1002/mnfr.70140","DOIUrl":"https://doi.org/10.1002/mnfr.70140","url":null,"abstract":"Chronic constipation (CC) and functional constipation (FC) are common gastrointestinal disorders that significantly affect quality of life. This study investigates the intestinal microbiota characteristics in CC and FC patients, revealing microbial imbalances characterized by reduced beneficial taxa, such as Acinetobacter, Blautia, Dorea formicigenerans, Eubacterium ramulus, and Halomonas, alongside increased levels of Alistipes, Holdemanella, Parabacteroides, Pseudomonas, Streptococcus, and so on. These findings highlight dysbiosis as a critical factor in constipation pathogenesis and provide a foundation for the bottom-up design of targeted probiotics and prebiotics. Potential therapeutic strategies include tailored probiotic formulations to replenish deficient taxa and the application of prebiotics to restore microbial balance. Additionally, the role of microbial metabolites, particularly short-chain fatty acids, and the microbiota-gut-brain axis offers further insight into mechanisms underlying symptom modulation. The integration of artificial intelligence enhances precision in probiotic design, enabling the prediction of strain-specific combinations optimized for therapeutic efficacy. This microbiota-centered approach underscores the potential for personalized interventions in addressing dysbiosis and advancing innovative management for CC and FC.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"14 1","pages":"e70140"},"PeriodicalIF":5.2,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome. 从甜菜根汁中增加硝酸盐摄入量超过4周会改变口腔微生物的组成，但不会改变肠道微生物群。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-16 DOI: 10.1002/mnfr.70156

Rebeka Fejes,Joana Séneca,Petra Pjevac,Martin Lutnik,Stefan Weisshaar,Nina Pilat,Romy Steiner,Karl-Heinz Wagner,Richard J Woodman,Catherine P Bondonno,Jonathan M Hodgson,David Berry,Michael Wolzt,Oliver Neubauer

{"title":"Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome.","authors":"Rebeka Fejes,Joana Séneca,Petra Pjevac,Martin Lutnik,Stefan Weisshaar,Nina Pilat,Romy Steiner,Karl-Heinz Wagner,Richard J Woodman,Catherine P Bondonno,Jonathan M Hodgson,David Berry,Michael Wolzt,Oliver Neubauer","doi":"10.1002/mnfr.70156","DOIUrl":"https://doi.org/10.1002/mnfr.70156","url":null,"abstract":"Inorganic dietary nitrate, metabolized through an endogenous pathway involving nitrate reducing bacteria, improves cardiovascular health, but its effects on the oral and intestinal microbiomes of older adults with treated hypertension are unknown. Our study investigated the effects of nitrate from beetroot juice on the oral and intestinal microbiomes of this population. A randomized, double-blind, placebo-controlled crossover trial was conducted with 15 participants (age range: 56-71 years), who consumed nitrate-rich or nitrate-depleted (placebo) beetroot juice for 4 weeks. The oral microbiome analysis revealed an increase in Neisseria and a decrease in Veillonella relative abundance (for both, PERMANOVA p < 0.001), with no significant changes in the intestinal microbiome composition. Our findings suggest that an increased dietary nitrate intake from a vegetable source may selectively modulate the oral microbiome and promote an increased abundance of nitrate-reducing species, which was previously associated with improved cardiovascular health outcomes.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"55 1","pages":"e70156"},"PeriodicalIF":5.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hidden Hunger: A Forgotten Comorbidity of Metabolic-Syndrome-Associated Fatty Liver Disease. 隐性饥饿：代谢综合征相关脂肪性肝病的一种被遗忘的共病

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-16 DOI: 10.1002/mnfr.70134

Peter Chinedu Agu,Jun Lu

{"title":"Hidden Hunger: A Forgotten Comorbidity of Metabolic-Syndrome-Associated Fatty Liver Disease.","authors":"Peter Chinedu Agu,Jun Lu","doi":"10.1002/mnfr.70134","DOIUrl":"https://doi.org/10.1002/mnfr.70134","url":null,"abstract":"Metabolic-syndrome-associated fatty liver disease (MAFLD), formally recognized as non-alcoholic fatty liver disease (NAFLD), is a growing global health challenge. MAFLD or NAFLD (M/NAFLD) pathophysiology is characterized by excessive fat accumulation in the liver, often driven by metabolic disorders such as obesity, insulin resistance, and dyslipidemia. Micronutrient deficiencies known as \"hidden hunger\" remain an underexplored comorbidity of M/NAFLD. Hidden hunger, caused by inadequate intake or poor bioavailability of essential vitamins and minerals, can exacerbate the pathophysiology of M/NAFLD through mechanisms such as oxidative stress, inflammation, and impaired lipid metabolism. This review examined the intricate interconnection between hidden hunger and M/NAFLD. Key micronutrients (vitamins D, E, A, and C, zinc, selenium, and magnesium) are critical in maintaining metabolic homeostasis and mitigating liver damage. Their deficiencies can accelerate M/NAFLD progression from simple steatosis to advanced stages like non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. We also highlight the diagnostic challenges posed by overlapping symptoms of hidden hunger and M/NAFLD and emphasize the need for comprehensive screening protocols. Evidence-based therapeutic strategies, including nutritional interventions and micronutrient supplementation, were explored for their potential to halt or reverse disease progression. We maintained that addressing hidden hunger offers a special chance to enhance results in M/NAFLD patients.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"228 1","pages":"e70134"},"PeriodicalIF":5.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlamydomonas reinhardtii (Red) Rich in Protoporphyrin IX Exerts Anti-Diabetic Effects in Liver Tissue. 富含原卟啉IX的莱茵衣藻（红色）在肝组织中的抗糖尿病作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-16 DOI: 10.1002/mnfr.70138

Zemi Xie,Zhuoling Chen,Siyuan Wang,Yamin Chen,Xue Zhang,Yuejin Wu,Yangjunna Zhang,Dengfeng Xu,Jingjin Hu,Yin Wang,Xuefeng Qu

{"title":"Chlamydomonas reinhardtii (Red) Rich in Protoporphyrin IX Exerts Anti-Diabetic Effects in Liver Tissue.","authors":"Zemi Xie,Zhuoling Chen,Siyuan Wang,Yamin Chen,Xue Zhang,Yuejin Wu,Yangjunna Zhang,Dengfeng Xu,Jingjin Hu,Yin Wang,Xuefeng Qu","doi":"10.1002/mnfr.70138","DOIUrl":"https://doi.org/10.1002/mnfr.70138","url":null,"abstract":"The metabolites derived from microalgae have been attributed with various nutritional and medicinal properties. Therefore, our research focused on exploring the potential benefits of Chlamydomonas reinhardtii (red) for type 2 diabetes mellitus (T2DM) patients. Mice were subjected to a high-fat diet and low-dose streptozotocin injection to develop T2DM. These diabetic mice were then treated orally with either 1% sodium carboxymethylcellulose or C. reinhardtii (red) at 1-3 g/kg BW/day for 4 weeks. Liver sections were stained with hematoxylin-eosin and oil red to assess pathological changes and lipid deposition. Serum inflammatory factors were measured using ELISA, and oxidative stress indicators were evaluated with commercial kits. C. reinhardtii (red) treatment significantly improved fasting glucose, body weight, triglycerides, LDL-C, and enhanced glucose tolerance and insulin sensitivity. It also reduced liver damage and lipid deposition. The treatment decreased G-6-Pase and PEPCK protein expression and modulated the SOCS2/JAK2/STAT5 pathway. RNA-seq analysis showed 972 differentially expressed genes in treated diabetic mice. KEGG analysis indicated the involvement of lipid metabolism, inflammation, and multiple pathways in the effects of C. reinhardtii (red). C. reinhardtii (red) might counteract T2DM by inhibiting gluconeogenesis and modulating key metabolic pathways, suggesting its potential as a dietary intervention for patients.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"10 1","pages":"e70138"},"PeriodicalIF":5.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flavonoid Polyphenols as Therapeutic Agents for Fatty Liver Disease: Mechanisms, Microbiome Interactions, and Metabolic Insights. 类黄酮多酚作为脂肪性肝病的治疗剂：机制、微生物组相互作用和代谢见解。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-06-16 DOI: 10.1002/mnfr.70144

Lei Li,Yanling Jin,Tiangang Li,Bijun Lv,Difen Yuan,Xiaoya Li,Jiali Yuan

引用次数: 0