Molecular Nutrition & Food Research最新文献

{"title":"Gastrodin as a Multitarget Anticancer Agent: Mechanisms, Pharmacokinetics, Toxicology, and Clinical Evidence","authors":"Akayed Hasan,&nbsp;Imam Hossen Rakib,&nbsp;Uzma Asif,&nbsp;Abul Bashar Ripon Khalipha,&nbsp;Mohammad Y. Alshahrani,&nbsp;Samy Selim,&nbsp;Md Asaduzzaman Jony,&nbsp;Emon Mia,&nbsp;Noshin Tasnim Yana,&nbsp;Rakib Hossan,&nbsp;Rituparna Biswas Suma,&nbsp;Md. Sakib Al Hasan","doi":"10.1002/mnfr.70613","DOIUrl":"10.1002/mnfr.70613","url":null,"abstract":"<div>\u0000 \u0000 <p>Gastrodin (GAS), a natural polyphenolic compound derived primarily from <i>Gastrodia elata</i>, exhibited a wide spectrum of pharmacological activities, with growing evidence supporting its anticancer potential. This review summarized preclinical findings on the anticancer effects of GAS across multiple cancer types, including brain, breast, colorectal, liver, oral, and skin cancers. The literature was systematically collected from major databases such as PubMed, Scopus, Web of Science, and Google Scholar, focusing on studies published from 2013 onward. Evidence indicates that GAS exerted anticancer effects via multiple cellular and molecular mechanisms, including apoptosis, ferroptosis, cell cycle arrest, inhibition of glycolysis, suppression of oncogenic signaling pathways (e.g., NF-κB, PI3K/Akt), immune modulation, and attenuation of inflammation and oxidative stress. Preclinical in vitro and in vivo studies demonstrated significant tumor growth suppression and the ability of GAS to overcome drug resistance. Pharmacokinetic studies revealed favorable drug-like properties, while toxicological evaluations highlighted its high safety margin with minimal adverse effects. Despite promising findings, the lack of clinical trials and standardized protocols remained a major limitation. Collectively, GAS represents a promising natural product candidate with potential as an adjunct or alternative anticancer therapy, warranting further translational and clinical investigation.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals”","authors":"","doi":"10.1002/mnfr.70616","DOIUrl":"10.1002/mnfr.70616","url":null,"abstract":"<p>J. Hu, M. D'Alessandro, P. Hansson, K. B. Holven, M. Thoresen, and S. M. Ulven, “Use of Metabotyping to Identify Individuals With Different Triglyceride Response Curves After Intake of High-Fat Meals,” <i>Molecular Nutrition &amp; Food Research</i> 70, no. 9 (2026): e70482, https://doi.org/10.1002/mnfr.70482.</p><p>Author contributions were missing.</p><p>This should have read:</p><p>J.H., M.D., K.B.H., M.T., and S.M.U. designed the research; P.H., K.B.H., and S.M.U. conducted the study trial. M.D. performed statistical analysis and was involved in the manuscript production. J.H. interpreted the data and wrote the manuscript. J.H., M.D., P.H., K.B.H., M.T., and S.M.U. reviewed the manuscript. All authors approved the final manuscript.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70616","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 18th World Congress on Polyphenols Applications 2025 and Beyond: Recent Advanced in the Field","authors":"Claus Schneider","doi":"10.1002/mnfr.70599","DOIUrl":"10.1002/mnfr.70599","url":null,"abstract":"&lt;p&gt;This special issue contains research articles and reviews based on presentations at the 18th World Congress on Polyphenols Applications held in Malta on October 2–3, 2025. Also included are manuscripts describing new developments in polyphenol research.&lt;/p&gt;&lt;p&gt;About half of the contributions in this collection are related to intestinal health: An important clinical study by Jamieson et al. describes results with xanthohumol, a flavonoid from hops, in subjects with clinically active Crohn's disease. At a low daily dose (48 mg), xanthohumol improved the disease activity index in a randomized placebo-controlled clinical trial spanning 8 weeks. Clinical improvement and changes in biomarkers were linked to modulation of the gut microbiome and bile acid metabolism. A pilot clinical study reported by Molino et al. used a prospective before/after design to suggest that a tannin phytocomplex may improve gastrointestinal and psychological symptoms in diarrhea-predominant irritable bowel syndrome. The study analyzed 28 subjects in a 60 day trial, and the positive outcome suggests that a larger controlled trial might be warranted. Zhao et al. tested the anthocyanin cyanidin-3-glucoside in the DSS colitis mouse model of inflammatory bowel disease. The anthocyanin improved cytokines, colon integrity, and achieved a shift toward a beneficial microbiome. The paper invokes effects on NF-κB and macrophage polarization as contributing effects. The last of the papers with an intestinal angle tested the role of taste receptors as targets of bitter-tasting phenolics. Richter et al. show that activation of three polyphenol-related receptors induced acid secretion in human parietal cells, pointing toward a possible mechanism of botanical remedies in relieving digestive discomfort.&lt;/p&gt;&lt;p&gt;Three clinical studies describe the possible application of polyphenols in unmet or difficult-to-treat clinical conditions. In a small pilot study, xanthohumol was tested in immunoglobulin A nephropathy, see the article by Jaroszynski et al. After 1 year of treatment with xanthohumol, proteinuria was decreased in all five subjects enrolled, erythrocyturia in four, and none had progressed to chronic kidney disease. Given that IgA nephropathy is a disease without a cure, this was an encouraging result. Liu et al. report that moderate to high intake of fruit-derived polyphenols was associated with a reduced risk for gestational hypertension, based on the analysis of dietary intake during early pregnancy in 2160 participants. The effect of polyphenol-rich food on healthy aging and especially on mental health was analyzed in a clinical study reported by Gomez Nieto et al. The potential of nutritional approaches to mitigate oxidative stress and inflammation in systemic arterial hypertension is reviewed by Castro da Silva et al.&lt;/p&gt;&lt;p&gt;This special issue is rounded up by a discussion of how dietary phytochemicals, including polyphenols and herbal medicines, shape cellular networks. In their re","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70599","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green and Efficient Extraction of Puerarin-Enriched Extracts From Pueraria lobata via Subcritical Ethanol-Water for Multi-Target Antidiabetic Effects","authors":"Xiang Zhou,&nbsp;Hao Chen,&nbsp;Changjian Xue,&nbsp;Jiayao Sun,&nbsp;Yukun Ma,&nbsp;Xiang Ma,&nbsp;Chenxi Wu,&nbsp;Jing Shi,&nbsp;Wei Chen,&nbsp;Hongliang Qian,&nbsp;Dechun Huang","doi":"10.1002/mnfr.70603","DOIUrl":"10.1002/mnfr.70603","url":null,"abstract":"<div>\u0000 \u0000 <p>Medicinal and edible plants are promising antidiabetic candidates due to their combined nutritional and pharmacological properties. However, the disconnection between bioactive substance extraction and efficacy validation hampers the development of integrated functional interventions. Here, a green and efficient subcritical ethanol-water extraction (SEWE) system was developed to obtain puerarin-enriched extracts (PEE) from <i>Pueraria lobata</i>. By introducing ethanol as a green polarity-modifying co-solvent, the SEWE system enabled polarity-tunable extraction under relatively mild subcritical conditions, thereby balancing extraction efficiency and compound stability. Compared with conventional extraction methods, SEWE significantly enhanced puerarin enrichment and overall extract quality, and the resulting extracts (SEWE-P) further exhibited enhanced bioactivities, including antioxidant, enzyme inhibitory, and anti-inflammatory effects, together with intracellular ROS-scavenging capacity, while maintaining good biocompatibility in vitro. In streptozotocin-induced diabetic mice, oral administration of SEWE-P significantly improved glycemic control, enhanced insulin sensitivity, and promoted pancreatic β-cell recovery. Mechanistically, SEWE-P activated the PI3K/AKT signaling pathway to improve glucose metabolism and suppressed NF-κB-mediated inflammation and oxidative stress. Overall, this study establishes an integrated green extraction–function evaluation strategy, providing a scalable approach for the development of multifunctional plant-based antidiabetic interventions.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postbiotic Intervention Improves Bowel Function and Promotes Systemic Health in Institutionalized Older Adults","authors":"María Bravo,&nbsp;Lizbeth D. Herrera Díaz,&nbsp;Carmen Bravo Santillana,&nbsp;Rosa Martín Terroso,&nbsp;Irene Simón,&nbsp;Rosario Cerrato","doi":"10.1002/mnfr.70610","DOIUrl":"10.1002/mnfr.70610","url":null,"abstract":"<div>\u0000 \u0000 <p>Postbiotic interventions represent a promising strategy to modulate gut health, but clinical evidence in older adults is limited. This study aimed to evaluate the effects of a postbiotic supplement consisting of inactivated bacterial cells on bowel function, systemic inflammation, and gut microbiota composition in institutionalized older adults. In this randomized, double-blind intervention study, 48 older adults received either postbiotic or placebo for 8 weeks. Daily assessment of gastrointestinal manifestations, bowel movements, and laxative use were collected, alongside pre- and post-intervention hematological and clinical biochemical assessments. Postbiotic supplementation improved bowel regularity, reduced diarrheal episodes, and decreased laxative reliance, effects that paralleled reductions in systemic inflammatory markers and improvements in red blood cell parameters. These clinical and hematological changes were accompanied by a more favorable gut microbiota profile, characterized by an increase in bacterial groups associated with anti-inflammatory effects in the postbiotic group and of taxa linked to dysbiosis in the placebo group. Our findings suggest that postbiotic supplementation in institutionalized older adults promotes beneficial shifts in gut microbiota, which are associated with reduced systemic low-grade inflammation and consequent improvements in bowel function and inflammation-related anemia, indicating an integrated microbiota-mediated mechanism supporting gut and systemic health.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148987388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence-Driven Multidimensional Phenotyping of Gut Metabolic States for Personalized Prebiotic, Probiotic, and Postbiotic Strategies","authors":"Andrej Tóth,&nbsp;Samuel Furka,&nbsp;Jerguš Vengríni,&nbsp;Pavel Neogrády,&nbsp;Andrej Bandura,&nbsp;Saul Dueñas Casas,&nbsp;Robert Petrovič,&nbsp;Miroslav Tomka,&nbsp;Ján Slopovský,&nbsp;Daniel Furka","doi":"10.1002/mnfr.70607","DOIUrl":"10.1002/mnfr.70607","url":null,"abstract":"<div>\u0000 \u0000 <p>This study presents multidimensional physicochemical phenotyping of human gut metabolic states using integrated multimodal profiling and machine learning. A total of 680 stool samples were analyzed using time-resolved optical, electrochemical, acoustic, magnetic, and spectral measurements implemented in a compact 3D-printed screening platform. Multivariate analysis explained 78.4% of structured variance, and cluster optimization identified seven primary clusters and 26 structurally retained subclusters representing proteolytic, saccharolytic, bile/lipid-rich, oxidative, diarrheal, pigment-linked, and normobiotic-like profiles. Clinical categories were linked to 21 subclusters after descriptor-based structure definition. A separate supervised layer assessed out-of-fold reproduction of fixed primary CL1-CL7 assignments, achieving 81.7% accuracy and a 0.799 macro F1-score in repeated cross-validation. Separately, cohort-internal diagonal category-to-subcluster distribution reached 84.1% (572/680 diagonal assignments, Wilson 95% CI: 81.2%–86.7%). 16S rRNA/laboratory-marker profiling supported the physicochemical structure, showing high diversity and low dysbiosis in the normobiotic-like phenotype, acidic high-diversity behavior in the saccharolytic phenotype, alkaline proteolytic behavior with elevated phenols and ammonia, bile-associated functional enrichment, and high dysbiosis with reduced diversity in the pigment-rich phenotype. SHAP and LIME attributed CL1-CL7 assignment to coordinated multimodal contributions. The method represents standardized extractable stool matrix profiling associated with microbiome-supported functional states, not a stand-alone diagnostic test.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"20th International Scientific Conference on Probiotics, Prebiotics, Postbiotics and Gut Microbes (IPC 2027), June 22–24, 2027, Kraków, Poland","authors":"Svetoslav Dimitrov Todorov,&nbsp;Ewa Hudson,&nbsp;Arthur C. Ouwehand","doi":"10.1002/mnfr.70608","DOIUrl":"10.1002/mnfr.70608","url":null,"abstract":"","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet, the Gut Microbiome, and Mental Health: Mechanistic Perspectives","authors":"Helal F. Hetta,&nbsp;Ragaa A. A. Hassan,&nbsp;Fawaz E. Alanazi,&nbsp;Saleh F. Alqifari,&nbsp;Mousa Aodh Albalwi,&nbsp;Ahmad A. Albalawi,&nbsp;Salwa Qasim Bukhari,&nbsp;Zinab Alatawi,&nbsp;Noura H. Abd Ellah,&nbsp;Yasmin N. Ramadan","doi":"10.1002/mnfr.70592","DOIUrl":"https://doi.org/10.1002/mnfr.70592","url":null,"abstract":"<div>\u0000 \u0000 <p>The microbiota–gut–brain axis (MGBA) represents a dynamic, bidirectional communication network linking the gut microbiome with central nervous system function through neural, immune, metabolic, and endocrine pathways. Emerging clinical, observational, and preclinical evidence suggests that special and restrictive dietary patterns—including Mediterranean, ketogenic, vegan, gluten-free, low-FODMAP, sugar-restricted, dairy-free diets, and intermittent fasting (IF)—can substantially modulate the gut microbiota, potentially influencing mental health outcomes. In this review, we first outline the fundamental mechanisms underlying gut–brain communication, emphasizing the roles of microbial metabolites, vagal nerve signaling, immune modulation, and hypothalamic–pituitary–adrenal (HPA) axis interactions. We then examine how distinct dietary interventions may alter gut microbial composition and metabolic activity, with potential implications for neuroimmune regulation, neurotransmitter synthesis, gut barrier integrity, and stress resilience. Current limitations in the field—including population heterogeneity, interindividual microbiome variability, limited longitudinal and mechanistic human studies, and challenges in clinical translation—are critically discussed. Finally, we propose future research directions aimed at developing personalized dietary strategies for mental health support through microbiome-targeted approaches. Understanding how special diets reshape the MGBA may provide promising avenues for the nutritional modulation of emotional and cognitive well-being.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148965639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Mol. Nutr. Food Res. 18'26","authors":"","doi":"10.1002/mnfr.70614","DOIUrl":"https://doi.org/10.1002/mnfr.70614","url":null,"abstract":"","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148965619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black Rice Anthocyanin–Hyaluronic Acid Complex Alleviates Hyperuricemia-Associated Renal Injury Through Synergistic Inhibition of the TLR4/NF-κB Pathway and Modulation of Uric Acid Transport","authors":"Jingyun Zhao,&nbsp;Ya Liu,&nbsp;Yuanjing Huang,&nbsp;Gang Xu,&nbsp;Bangzhu Peng","doi":"10.1002/mnfr.70605","DOIUrl":"10.1002/mnfr.70605","url":null,"abstract":"<div>\u0000 \u0000 <p>Hyperuricemia-associated renal injury is closely linked to oxidative stress and inflammation, highlighting the need for safe dietary intervention. This study evaluated the protective effects of a black rice anthocyanin (ATC)–hyaluronic acid complex (HAA) against uric acid (UA)-induced injury. In UA-induced human renal proximal tubular epithelial (HK-2) cells, black rice ATCs, HA, and HAA improved cell viability and antioxidant defenses, as shown by increased glutathione (GSH) levels and catalase (CAT) and superoxide dismutase (SOD) activities. They also reduced malondialdehyde (MDA), reactive oxygen species (ROS), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). HAA produced a greater reduction in TLR4/NF-κB-related inflammatory gene expression, suggesting that its cytoprotective and anti-inflammatory effects may be associated with modulation of this inflammatory axis. In hyperuricemic mice, HAA lowered serum UA, creatinine, and blood urea nitrogen levels, inhibited hepatic xanthine oxidase and adenosine deaminase activities, and attenuated renal histopathological injury. HAA also reduced the mRNA expression of urate reabsorption-related genes, including GLUT9, OAT4, and OAT10, while increasing that of urate excretion-related genes, including OAT1 and ABCG2, which may contribute to improved urate homeostasis. These findings support the potential of HAA as a functional dietary ingredient for the management of hyperuricemia-associated metabolic disturbances and renal injury.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148915401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}