Molecular Nutrition & Food Research最新文献_第10页

Exploring the Impact of a High‐Fat Diet on Brain Homeostasis: A Comprehensive Analysis of the Absence of Inflammation 探索高脂肪饮食对大脑内稳态的影响：对炎症缺失的综合分析

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-28 DOI: 10.1002/mnfr.70168

Laura Plantera, Kerstin Immig, Anne‐Kristin Fritsche, Madlen Reinicke, Alon Zemer, Alon Monsonego, Uta Ceglarek, Ingo Bechmann

{"title":"Exploring the Impact of a High‐Fat Diet on Brain Homeostasis: A Comprehensive Analysis of the Absence of Inflammation","authors":"Laura Plantera, Kerstin Immig, Anne‐Kristin Fritsche, Madlen Reinicke, Alon Zemer, Alon Monsonego, Uta Ceglarek, Ingo Bechmann","doi":"10.1002/mnfr.70168","DOIUrl":"https://doi.org/10.1002/mnfr.70168","url":null,"abstract":"Excessive fat consumption increases the risk of Alzheimer's disease (AD), potentially through diet‐induced neuroinflammation. Microglia, the brain's immune cells, are affected by obesity and diet. Phytosterols (PS), plant‐derived cholesterol‐like compounds, accumulate in the brain with age, and their content correlates with dietary intake. We hypothesize that the accumulation of PS modulates microglial activation and exerts anti‐inflammatory effects. We investigated the effects of a normal diet (ND), high‐fat diet (HFD), HFD with 2% PS (HFD+2% PS), and HFD with 4% PS (HFD+4% PS) on neuroinflammation in female and male C57BL/6J mice. Flow cytometry (FC) of microglia showed no significant regulation of pro‐ (IFN‐γ, IL‐1β, TNF‐α) and anti‐inflammatory (IL‐10) cytokines due to diet, but sex‐ and age‐dependent differences were observed. Immunofluorescence staining showed no TREM2 upregulation, indicating a lack of microglial activation in response to HFD. PS supplementation significantly reduced HFD‐induced weight gain, suggesting metabolic effects. Contrary to existing research, we found no evidence of HFD‐induced neuroinflammation or microglial activation. However, the reduction in weight gain with PS supplementation suggests potential metabolic benefits, which could have implications for the treatment of obesity. The potential effects on neuroinflammation remain unclear.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"133 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to the EAT‐Lancet Diet, Genetically Predicted Gut Butyrate and the Risk of Incident Cardiometabolic Multimorbidity: A Prospective Analysis 坚持EAT - Lancet饮食、基因预测肠道丁酸盐和心血管代谢多病发生风险的前瞻性分析

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-28 DOI: 10.1002/mnfr.70188

Shuxian Chen, Chao Ji, Xiang Ji, Chenying Wang, Ruiyao Zhang, Duoduo Lu, Xin Yang, Jinguo Jiang, Huixu Dai, Yang Xia

{"title":"Adherence to the EAT‐Lancet Diet, Genetically Predicted Gut Butyrate and the Risk of Incident Cardiometabolic Multimorbidity: A Prospective Analysis","authors":"Shuxian Chen, Chao Ji, Xiang Ji, Chenying Wang, Ruiyao Zhang, Duoduo Lu, Xin Yang, Jinguo Jiang, Huixu Dai, Yang Xia","doi":"10.1002/mnfr.70188","DOIUrl":"https://doi.org/10.1002/mnfr.70188","url":null,"abstract":"Our study aimed to explore the correlation between the EAT‐Lancet diet and cardiometabolic multimorbidity (CMM) risk and the potential role of gut butyrate in this relationship. Our study encompassed 136,910 UK Biobank participants who had completed at least one validated 24‐h online dietary recall questionnaire and had at most one cardiometabolic disease at recruitment. The EAT‐Lancet diet index, scaled from 0 to 42, was used to categorize adherence into quartiles: Q1: <19, Q2: 19–22, Q3: 22–25, and Q4: ≥25 points. We employed COX proportional hazard models to calculate hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs). An inverse association was observed between the EAT‐Lancet and CMM risk (HR: 0.95; 95% CI: 0.91–0.99), with a significant linear trend (p for trend = 0.021). A more pronounced relationship between the EAT‐Lancet diet and CMM was found in those with lower genetically predicted gut butyrate levels. Joint analysis showed that those with high genetically predicted gut butyrate and high EAT‐Lancet adherence had the lowest CMM risk (HR: 0.82, 95% CI: 0.69–0.96). Higher adherence to the EAT‐Lancet diet was associated with a lower risk of incident CMM, with a stronger protective effect observed among individuals with lower genetically predicted gut butyrate levels.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"708 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stevioside Improves Liver Insulin Resistance in Prediabetic Mice via IRS1/PI3K/AKT Signaling Pathway. 甜菊苷通过IRS1/PI3K/AKT信号通路改善糖尿病前期小鼠肝脏胰岛素抵抗

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-25 DOI: 10.1002/mnfr.70190

Changfa Zhang,Lili Kang,Kangjun Li,Jingyi Zhang,Yingxin Liu,Ruoting Wang,Guowei Li

{"title":"Stevioside Improves Liver Insulin Resistance in Prediabetic Mice via IRS1/PI3K/AKT Signaling Pathway.","authors":"Changfa Zhang,Lili Kang,Kangjun Li,Jingyi Zhang,Yingxin Liu,Ruoting Wang,Guowei Li","doi":"10.1002/mnfr.70190","DOIUrl":"https://doi.org/10.1002/mnfr.70190","url":null,"abstract":"Prediabetes progression to type 2 diabetes mellitus (T2DM) can be effectively prevented by adequate dietary intervention via improved liver insulin resistance. Stevioside, as a natural and safe sweetener, has been shown to have antidiabetic properties. However, whether stevioside can enhance liver insulin resistance in prediabetes remains unclear. We therefore aimed to investigate the effect and molecular mechanisms of stevioside on liver insulin resistance in prediabetes. Prediabetic mice were induced using a high-fat diet and treated with stevioside for 8 weeks. The effects of stevioside on gene expression levels and signaling pathways in the mice liver were investigated by RNA-seq and gene enrichment analysis. We also treated the palmitic acid-induced insulin-resistance AML-12 cells with stevioside, and measured glucose uptake in insulin-stimulated cells with 2-NBDG. The expression levels of genes and proteins related to the insulin signaling pathway were detected using qRT-PCR and Western blotting. Stevioside improved glucose tolerance and plasma insulin levels in prediabetic mice with insulin resistance and enhanced liver function. Stevioside could improve liver insulin resistance via IRS1/PI3K/AKT signaling pathway in prediabetic mice. Similarly, stevioside decreased the level of p-IRS1 and increased the levels of p-PI3K p85α, AKT, and p-AKT in AML-12 cells. Stevioside could improve glucose tolerance in prediabetic mice with insulin resistance, and ameliorate liver insulin resistance by regulating the IRS1/PI3K/AKT signaling pathway. These results may support stevioside as a potential dietary approach for preventing prediabetes progression to T2DM.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"710 1","pages":"e70190"},"PeriodicalIF":5.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the Consumption of Lean Red Meat from Beef (Pirenaica Breed) Versus Lean White Meat (Chicken) on the Gut Microbiota: A Randomized Cross-Over Study in Healthy Young Adults. 食用红瘦牛肉与白瘦鸡肉对健康年轻人肠道微生物群的影响：一项随机交叉研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-25 DOI: 10.1002/mnfr.70189

Isabel Rueda-De Torre,Julio Plaza-Diaz,María L Miguel-Berges,Angel Gil,Laura Grasa,Luis Mariano Esteban,Sergio Sabroso-Lasa,María M Campo,Pilar Santolaria,Luis A Moreno,Alba M Santaliestra-Pasías

{"title":"Effect of the Consumption of Lean Red Meat from Beef (Pirenaica Breed) Versus Lean White Meat (Chicken) on the Gut Microbiota: A Randomized Cross-Over Study in Healthy Young Adults.","authors":"Isabel Rueda-De Torre,Julio Plaza-Diaz,María L Miguel-Berges,Angel Gil,Laura Grasa,Luis Mariano Esteban,Sergio Sabroso-Lasa,María M Campo,Pilar Santolaria,Luis A Moreno,Alba M Santaliestra-Pasías","doi":"10.1002/mnfr.70189","DOIUrl":"https://doi.org/10.1002/mnfr.70189","url":null,"abstract":"Limited evidence exists regarding the impact of meat consumption on the human gut microbiota, with factors such as animal source, production system, and cooking methods often overlooked. This study evaluates the effect of Pirenaica breed beef or conventional chicken-based diets on the gut microbiota of healthy adults. A randomized cross-over controlled trial with two 8-week periods, separated by a 5-week washout, is carried out. Participants consume either Pirenaica breed beef or chicken three times per week with their diet. Stool samples are collected at the beginning and end of each period. Gut microbiota is analyzed via amplification and sequencing of V3-V4 regions of 16S rRNA. Alpha diversity and relative abundances at phylum and genus levels are calculated. Sixteen participants are included (mean age 20.12 ± 2.36 years). Both diets induce modest changes in microbial composition, with no significant differences between groups. At the phylum level, Bacillota increased, while Synergistota, Chloroflexota, and Pseudomonadota decreased. Alpha diversity parameters declined significantly after the chicken-based diet, although overall reduction in microbial diversity was observed across both interventions. The consumption of lean red meat or lean white meat as part of habitual diet produces similar effects on the gut microbiota.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"16 1","pages":"e70189"},"PeriodicalIF":5.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 14'25 发布信息：Mol. Nutr。Food Res. 14'25

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-22 DOI: 10.1002/mnfr.70176

引用次数: 0

Front Cover: Effects of a Functional Food Mixture on Patients Undergoing Hemodialysis: Preliminary Results Highlighting the Modulation of Uremic Toxins Derived From Microbiota and Antioxidant Markers 封面：功能性食物混合物对血液透析患者的影响：强调来自微生物群和抗氧化标志物的尿毒症毒素调节的初步结果

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-22 DOI: 10.1002/mnfr.70180

Danielle Nascimento, Isadora Britto, Heloiza Couto, Livia Alvarenga, Ludmila F. M. F. Cardozo, Andresa A. Berretta, Marcelo Ribeiro-Alves, Danielle Figueiredo da Cunha, Carolina de Oliveira Ramos Petra de Almeida, Isabela Lemos, Mônica Martins Guimarães Guerra, Maria E. S. Costa, Lia S. Nakao, Anderson J. Teodoro, Denise Mafra

引用次数: 0

Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research 大鼠模型中的餐后代谢、炎症和血浆胆汁酸动力学：对转化研究的启示

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-22 DOI: 10.1002/mnfr.70174

Larissa Rodrigues, Carlos M. Donado‐Pestana, Tushar More, Mar Garcia‐Aloy, Gustavo M. Carneiro de Lima, Lucas X. Martins de Oliveira, Urska Vrhovsek, Karsten Hiller, Jarlei Fiamoncini

{"title":"Postprandial Metabolism, Inflammation, and Plasma Bile Acid Kinetics in a Rat Model: Implications for Translational Research","authors":"Larissa Rodrigues, Carlos M. Donado‐Pestana, Tushar More, Mar Garcia‐Aloy, Gustavo M. Carneiro de Lima, Lucas X. Martins de Oliveira, Urska Vrhovsek, Karsten Hiller, Jarlei Fiamoncini","doi":"10.1002/mnfr.70174","DOIUrl":"https://doi.org/10.1002/mnfr.70174","url":null,"abstract":"The postprandial period is an opportunity window to assess metabolic phenotype, and its study is gaining popularity due to the wealth of information that can be uncovered when a dietary challenge is associated with the application of metabolomics approaches. Bile acids (BA) were recently identified as signaling molecules that display major changes in circulating levels following food intake. In this regard, a gap of information remains linking BA postprandial kinetics with their possible metabolic effects. This study aimed to characterizing a murine model for investigating postprandial metabolism and inflammation. Changes in plasma and hepatic markers of metabolism, inflammation and BA levels were assessed in male Sprague‐Dawley rats before and after the ingestion of an energy‐dense meal. Rats display postprandial alterations in circulating BA levels, with cholic acid constituting the predominant species (36%). These changes are accompanied by shifts in intermediates of energy metabolism and inflammatory markers, as demonstrated by a four‐fold increase in hepatic NF‐κB protein content, a key inflammatory transcription factor, two hours after food intake. Despite inherent species‐specific differences, this murine model represents a promising tool for studying postprandial modulation energy metabolism, establishing a pioneering framework for future investigations into the role of BA in postprandial metabolic responses.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"14 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population. 加勒比西班牙裔人群食物摄入生物标志物的探索。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-21 DOI: 10.1002/mnfr.70158

Laurence D Parnell,Liam E Fouhy,Oladimeji Akinlawon,Chao-Qiang Lai,Frederick Nusetor,José M Ordovás,Kelsey M Mangano,Katherine L Tucker,Sabrina E Noel

{"title":"Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.","authors":"Laurence D Parnell,Liam E Fouhy,Oladimeji Akinlawon,Chao-Qiang Lai,Frederick Nusetor,José M Ordovás,Kelsey M Mangano,Katherine L Tucker,Sabrina E Noel","doi":"10.1002/mnfr.70158","DOIUrl":"https://doi.org/10.1002/mnfr.70158","url":null,"abstract":"Valid measures of dietary intake are essential for health and nutrition research, but typical forms- or interview-based measurements are susceptible to random and systematic errors. Although many biomarkers of food intake (BFIs) have been validated, we aimed to explore how food-BFI relationships are affected by genetic and lifestyle factors among Caribbean Hispanic adults. Dietary, clinical, anthropometric, blood metabolomics, and genotype data from 782 Puerto Rican adults were available. Thirty-one BFI-food intake relationships were assessed using linear regression, including covariates based on significant covariate-BFI associations (i.e., age, body weight, physical activity, and sex). We observed 12 known BFI-food pairs that reached statistical significance, of which 11 remained significant after adjustment. Applying genome-wide association tests of blood metabolites to BFI-food pairs, genetic variants rs7078243 and rs62501664 were identified as modifying relationships with 3-methylxanthine-coffee and 3-methylhistidine-poultry, respectively. Eleven validated biomarker-food intake pairs remained statistically significant after adjusting for covariates. Identification of genotype-BFI associations accentuates that the implementation of certain BFIs will depend on common genetic differences.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"8 1","pages":"e70158"},"PeriodicalIF":5.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saucerneol Inhibits the Growth, Migration, and Invasion of Osteosarcoma Cells In Vitro and Prevents Metastasis-Associated Osteolysis Ex Vivo. Saucerneol在体外抑制骨肉瘤细胞的生长、迁移和侵袭，并防止转移相关的骨溶解。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-20 DOI: 10.1002/mnfr.70187

Hyung-Mun Yun,Nguyen Xuan Nhiem,SeonJu Park,Kyung-Ran Park

{"title":"Saucerneol Inhibits the Growth, Migration, and Invasion of Osteosarcoma Cells In Vitro and Prevents Metastasis-Associated Osteolysis Ex Vivo.","authors":"Hyung-Mun Yun,Nguyen Xuan Nhiem,SeonJu Park,Kyung-Ran Park","doi":"10.1002/mnfr.70187","DOIUrl":"https://doi.org/10.1002/mnfr.70187","url":null,"abstract":"Saururus chinensis has traditionally been used to treat various diseases. Biologically active compounds isolated from S. chinensis exhibit diverse pharmacological activities. The aim of this study was to investigate the antiosteosarcoma effects of saucerneol (Sauc), a lignan, purified from the aerial parts of S. chinensis using in vitro and ex vivo experimental models. Sauc was purified from the methanolic extract of S. chinensis. It exhibited toxicity against MG63 and SJSA-1 cells (human osteosarcoma cell lines), inducing apoptotic morphological changes and suppressing cell migration. Sauc triggered PARP cleavage and decreased the expression of antiapoptotic proteins. It also disrupted mitochondrial membrane potential and increased reactive oxygen species (ROS) generation. Proteome profiling, western blotting, and immunocytochemistry revealed that Sauc inhibited the JAK2/STAT3 pathway. Furthermore, Sauc downregulated the expression of metastasis-associated proteins, suppressed invasion through extracellular matrix-coated membranes, and inhibited anchorage-independent cell growth. In an ex vivo bone organ culture, Sauc attenuated tumor-induced osteolysis. This study demonstrated that Sauc exerts anti-osteosarcoma effects by inducing apoptosis, inhibiting cell migration and invasion in vitro, and mitigating metastasis-associated bone degradation ex vivo. Thus, Sauc holds promise as a protective compound in daily health supplements and a therapeutic agent against human osteosarcoma.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"76 1","pages":"e70187"},"PeriodicalIF":5.2,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameliorative Potential of Synthetic Flavone-Derivative in Diabetes-Associated Neurodegeneration. 合成黄酮类衍生物对糖尿病相关神经变性的改善潜力。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-17 DOI: 10.1002/mnfr.70172

Karishma Sen,Anita Sakarwal,Heera Ram,Suman K Saha,Nirmal K Rana,Dharamveer Yadav,Mukesh Kumar Yadav,Balachandar Vellingiri,Mariusz Jaremko,Habibullah Khalilullah,Amita Verma,Vikas Kumar,Anil Panwar

{"title":"Ameliorative Potential of Synthetic Flavone-Derivative in Diabetes-Associated Neurodegeneration.","authors":"Karishma Sen,Anita Sakarwal,Heera Ram,Suman K Saha,Nirmal K Rana,Dharamveer Yadav,Mukesh Kumar Yadav,Balachandar Vellingiri,Mariusz Jaremko,Habibullah Khalilullah,Amita Verma,Vikas Kumar,Anil Panwar","doi":"10.1002/mnfr.70172","DOIUrl":"https://doi.org/10.1002/mnfr.70172","url":null,"abstract":"The current study was carried out to explore the neuroprotective efficacy of the synthesized compound 2-(1,3-benzodioxol-5-yl)-4H-chromen-4-one 5 (2BDC45) in diabetes-associated neurodegeneration through in silico and in vivo assessments. In silico exploration of molecular docking showed a significant binding energies of -8.5, -9.3, and -7.4 kcal/mol for 2BDC45 against the target enzymes, i.e., acetylcholinesterase, butyrylcholinesterase, and DPP-4, respectively. These findings were further confirmed through 100 ns molecular dynamics simulations, assessing parameters like RMSD, RMSF, SASA, MMPBSA, and PCA. Treatment with 2BDC45 exhibited the neuroprotective changes in the hippocampus and cortex regions of type 2 diabetes-associated neurodegenerations. Consequently, histopathological analysis of these brain regions, supported by molecular biological analyses of key genes such as GLUT-3, GSK, MAP, and PPARγ corroborated the neuroprotection. The lipid profile, HOMA, and antioxidants exhibited notable changes by the interference of the treatments. The treatments shown significant ameliorations in glucose metabolism by following the expressions of GLUT-3 and GSK, while MAP kinase and PPARγ showed significant restorations in the cortex and hippocampus. In conclusion, it can be implied the test flavone derivative has the capacity to amplify neural plasticity by following the scavenging of free radicals, improved glucose metabolism, and targeted genes expression.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"46 1","pages":"e70172"},"PeriodicalIF":5.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0