Molecular Nutrition & Food Research最新文献_第9页

Fermented and Germinated Samh Seeds Reduces Hyperlipidemia, Oxidative Stress, and Inflammation in Rats a Fed High-Fat Diet. 发酵和发芽的Samh种子降低高脂肪饮食大鼠的高脂血症、氧化应激和炎症。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-09 DOI: 10.1002/mnfr.70204

Belal M Mohammed,Isam A Mohamed Ahmed,Ghedeir M Alshammari,Magdi A Osman,Mohammed Abdo Yahya

{"title":"Fermented and Germinated Samh Seeds Reduces Hyperlipidemia, Oxidative Stress, and Inflammation in Rats a Fed High-Fat Diet.","authors":"Belal M Mohammed,Isam A Mohamed Ahmed,Ghedeir M Alshammari,Magdi A Osman,Mohammed Abdo Yahya","doi":"10.1002/mnfr.70204","DOIUrl":"https://doi.org/10.1002/mnfr.70204","url":null,"abstract":"Hyperlipidemia contributes to hepatic dysfunction, oxidative stress, chronic inflammation, and cardiovascular diseases (CVDs). This study examines the protective effects of raw (raw samh seed flour [RSSF]), germinated (germinated samh seeds flour [GSSF]), and fermented (fermented samh seeds flour [FSSF]) samh seed flour against high-fat diet (HFD)-induced metabolic disturbances in rats.Forty-eight rats were divided into six groups and fed either a standard diet, HFD, or HFD supplemented with 15% RSSF, GSSF, or FSSF for 8 weeks. The FSSF group exhibited the most pronounced reduction in body weight gain, fasting glucose, insulin resistance (homeostatic model assessment of insulin resistance [HOMA-IR]), and serum/liver lipids. FSSF also significantly decreased proinflammatory cytokines (tumor necrosis factor-alpha [TNF-α], interleukin 6 [IL-6], and interleukin-1 beta [IL-1β]) and oxidative stress markers (malondialdehyde [MDA]), while enhancing antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], and total glutathione [GSH]) and IL-10 levels. Histological analysis revealed marked improvements in liver structure in the FSSF group compared to the HFD group.Fermented samh seed flour notably attenuates hyperlipidemia, inflammation, and oxidative stress while preserving hepatic integrity, highlighting its potential as a functional dietary intervention for managing metabolic syndrome and related liver disorders.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"143 1","pages":"e70204"},"PeriodicalIF":5.2,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Nutrition on Sphingolipid-Regulated Physiology: A Review. 营养对鞘脂调节生理的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-08 DOI: 10.1002/mnfr.70182

Jonas Voß,Thorsten Hornemann,Bengt-Frederik Belgardt

{"title":"Impact of Nutrition on Sphingolipid-Regulated Physiology: A Review.","authors":"Jonas Voß,Thorsten Hornemann,Bengt-Frederik Belgardt","doi":"10.1002/mnfr.70182","DOIUrl":"https://doi.org/10.1002/mnfr.70182","url":null,"abstract":"Sphingolipids (SLs) are a very diverse group of lipids already described by German physician Johann Thudichum in 1884. The name of these lipids originates from their (at the time) enigmatic nature and lack of knowledge about their cellular function, which was compared to the creature sphinx in Greek mythology. Today we know that SLs play an important role in a plethora of physiological and cellular processes, including tissue development, growth regulation, apoptosis, adhesion, cell migration, cell senescence, receptor signaling, and hormonal effects and are associated with multiple pathological processes in many different disease contexts. In addition to roles for specific SLs in developmental processes, their critical role in causing and preventing metabolic diseases, including cardiovascular disease, obesity, and diabetes during adulthood, has been uncovered through targeted genetic manipulation, lipidomics, and advanced biochemical analyses such as lipid-protein interactomics. Notably, in the context of maternal and paternal effects on offspring and their risk for metabolic disease, there is a gap in our knowledge regarding SLs in transgenerational disease mechanisms. This review summarizes our knowledge on SL metabolism and cellular roles in health and disease, while focusing on the current knowledge of dietary effects on SL-controlled metabolism of adults and their developing offspring.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"37 1","pages":"e70182"},"PeriodicalIF":5.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized Controlled Trial: Effects of a Bitter-Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects. 随机对照试验：低水解程度的苦味豌豆蛋白水解干预对中等超重男性受试者能量摄入的影响。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-08 DOI: 10.1002/mnfr.70195

Katrin Gradl,Sonja Sterneder,Kristin Kahlenberg,Beate Brandl,Thomas Skurk,Veronika Somoza

{"title":"Randomized Controlled Trial: Effects of a Bitter-Tasting Pea Protein Hydrolysate Intervention With Low Degree of Hydrolyzation on Energy Intake in Moderately Overweight Male Subjects.","authors":"Katrin Gradl,Sonja Sterneder,Kristin Kahlenberg,Beate Brandl,Thomas Skurk,Veronika Somoza","doi":"10.1002/mnfr.70195","DOIUrl":"https://doi.org/10.1002/mnfr.70195","url":null,"abstract":"Optimizing plant-based protein intake, such as pea protein hydrolysates (PPHs), may aid in obesity management. This study investigated whether PPHs with varying bitterness and degrees of hydrolysis (DH) differently affect satiety in healthy male participants. In a short-term randomized control trial, 19 moderately overweight men (BMI 25-30 kg/m2) consumed boluses of 75 g glucose plus 15 g PPH (control without PPH; PPH1: less bitter, DH = 35%; PPH2: more bitter, DH = 23%). Upon PPH administration, energy intake from an ad libitum breakfast was reduced by -126 ± 329 kcal (p < 0.05) in the PPH2 group compared to the control. PPH1 decreased plasma ghrelin and DPP-4 levels (AUC: -9.4 ± 19.6 and -12.5 ± 24.7, p < 0.05). Gastric emptying was delayed by a mean of 65% (p < 0.0001) after PPH2 consumption, assessed via 13C-Na-acetate breath test. Bitterness and DH of PPH influence satiety signals differently. PPH1 (less bitter, higher DH) reduces DPP-4 and ghrelin levels, promoting satiety. PPH2 (more bitter, lower DH) delays gastric emptying, enhancing satiation. These findings highlight the potential of PPHs as functional ingredients in weight management strategies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"14 1","pages":"e70195"},"PeriodicalIF":5.2,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant-Like Effect of Saffron (Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity. 藏红花（Crocus sativus L.）通过减轻神经炎症和恢复神经可塑性对慢性不可预测轻度应激小鼠的抗抑郁样作用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-07 DOI: 10.1002/mnfr.70201

Jiexin Zhou,Yuemei Hu,Pu Jing

{"title":"Antidepressant-Like Effect of Saffron (Crocus sativus L.) in Mice Exposed to Chronic Unpredictable Mild Stress via Attenuating Neuroinflammation and Recovering Neuroplasticity.","authors":"Jiexin Zhou,Yuemei Hu,Pu Jing","doi":"10.1002/mnfr.70201","DOIUrl":"https://doi.org/10.1002/mnfr.70201","url":null,"abstract":"Saffron (Crocus sativus L.), a traditional food coloring and flavoring ingredient, has shown potential antidepressant activity in several preclinical and clinical studies. This study investigated the antidepressant effect and underlying mechanism of saffron extract (SE) using a chronic unpredictable mild stress (CUMS)-induced depressive mouse model. Mice subjected to 8-week CUMS were orally administered with SE or positive medicine fluoxetine for 6 weeks. Behavioral tests, histopathological analysis, proinflammatory cytokine levels, and protein/mRNA expression were evaluated to characterize the antidepressant effects of SE. Results showed SE improved depression-like behaviors, ameliorated hippocampal and neuronal damage, remitted neuroinflammation, and restored neuroplasticity in mice. The antineuroinflammatory effect of SE may be attributed to inhibition of microglial activation, NF-κB signaling pathway, and proinflammatory cytokines' secretion. In addition, the upregulation of hippocampal Creb, Bdnf, and Trkb, and related proteins by SE treatment may be a mechanism for neuroplasticity recovery. These results demonstrated the antidepressant effects of SE in a CUMS-induced depressive model and manifested the potential of saffron as a functional food for relieving depression.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"7 1","pages":"e70201"},"PeriodicalIF":5.2,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Lactobacillus plantarum Extracellular Vesicles on Lipid Metabolism in Mice Fed a High-Fat Diet. 植物乳杆菌胞外囊泡对高脂饲料小鼠脂质代谢的影响。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-06 DOI: 10.1002/mnfr.70183

Shan-Shan Xu, Chun-Jing Yu, Meng-Yao Qin, Yan Zhang, Jia-Ping Jiang, Wei Liu, Yu Pan, Song Zhang, Xiao-Yu Zhao

{"title":"Effect of Lactobacillus plantarum Extracellular Vesicles on Lipid Metabolism in Mice Fed a High-Fat Diet.","authors":"Shan-Shan Xu, Chun-Jing Yu, Meng-Yao Qin, Yan Zhang, Jia-Ping Jiang, Wei Liu, Yu Pan, Song Zhang, Xiao-Yu Zhao","doi":"10.1002/mnfr.70183","DOIUrl":"https://doi.org/10.1002/mnfr.70183","url":null,"abstract":"<p><p>This thesis aims to investigate the role of extracellular vesicles of Lactobacillus plantarum (LPEVs) in the regulation of high-fat diet (HFD)-induced disorders of lipid metabolism.We used ultracentrifugation to obtain LPEVs and performed preliminary characterization. After an obese mouse model was established via HFD feeding, LPEVs were used to treat mice with lipid metabolism disorders, and changes in the body weight, blood lipid levels, tissue levels, intestinal flora structure, differential metabolites, and regulation of key signaling pathway genes in these mice were observed. The LPEVs reduced body weight, alleviated aberrant lipid metabolism and inflammatory responses, improved the morphological structure of the ileum, enriched the intestinal flora, influenced the production of metabolites, and regulated genes associated with lipid metabolism in mice.Consequently, LPEVs intervention seems to regulate lipid metabolism disorders by regulating the gut microbiota and improving nutrient absorption, thereby optimizing lipid metabolism, and providing a theoretical basis for future research on the regulation of lipid metabolism by probiotic metabolites.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70183"},"PeriodicalIF":4.2,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolics-Rich Extract from Agarwood Leaf-Tea Alleviate Dextran Sulfate Sodium (DSS)-Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota 沉香叶茶富含酚类物质的提取物通过调节肠道屏障功能、肝脏炎症和肠道微生物群减轻葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-05 DOI: 10.1002/mnfr.70192

Ruyan Fan, Wensong Wei, Youjing Wei, Xue Lin, Shaobo Zhou, Lu Wang

引用次数: 0

Tea Polyphenols Reduced Obesity by Modulating Gut Microbiota-SCFAs-Barrier and Inflammation in High-Fat Diet-Induced Mice 茶多酚通过调节高脂饮食诱导小鼠的肠道微生物- scfa -屏障和炎症来减少肥胖

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-05 DOI: 10.1002/mnfr.70193

Baoming Tian, Pinjiao Huang, Yizhu Pan, Hong Gu, Kai Yang, Zhengxun Wei, Xiangchun Zhang

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 15'25 发布信息：Mol. Nutr。Food Res. 15'25

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-04 DOI: 10.1002/mnfr.70185

引用次数: 0

Oleuropein Mitigates Radiation‐Induced Neurodegeneration in Rats by Modulating Oxidative, Vascular, and Apoptotic Pathways 橄榄苦苷通过调节氧化、血管和凋亡通路减轻辐射诱导的大鼠神经变性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-01 DOI: 10.1002/mnfr.70196

Umit Kara, Ozlem Ozmen, Okan Sancer, Simge Garlı

{"title":"Oleuropein Mitigates Radiation‐Induced Neurodegeneration in Rats by Modulating Oxidative, Vascular, and Apoptotic Pathways","authors":"Umit Kara, Ozlem Ozmen, Okan Sancer, Simge Garlı","doi":"10.1002/mnfr.70196","DOIUrl":"https://doi.org/10.1002/mnfr.70196","url":null,"abstract":"Radiation (RAD) is widely used in medicine but poses risks to non‐regenerative tissues such as the brain. This study aimed to investigate the neuroprotective effects of oleuropein (OLE) against RAD‐induced brain injury in rats by evaluating oxidative stress, apoptosis, and vascular responses. Thirty‐two male Wistar rats were randomly assigned to four groups: Control, RAD (6 Gy cranial irradiation), RAD+OLE (50 mg/kg/day oral gavage, initiated 1 week before and continued 3 weeks after irradiation), and OLE alone. Histopathological (H&E, PAS), immunohistochemical (Cyclin‐D1, CD31, GLUT‐1), biochemical (serum CK‐BB), and molecular (Bax, Bcl‐2 mRNA via RT‐qPCR) analyses were performed. RAD exposure resulted in significant neuronal degeneration, upregulation of Cyclin‐D1, CD31, and GLUT‐1 expression, increased pro‐apoptotic Bax, decreased anti‐apoptotic Bcl‐2, and elevated serum CK‐BB (p < 0.05). OLE treatment significantly attenuated these alterations, restoring brain tissue architecture, normalizing PAS staining, downregulating apoptotic and vascular markers, and reducing CK‐BB levels (p < 0.05). These findings suggest that OLE exerts potent neuroprotective effects against RAD‐induced brain damage by attenuating oxidative stress, vascular activation, and apoptosis. OLE may serve as a promising adjuvant in radiotherapy to reduce central nervous system (CNS) side effects. Further studies focusing on functional outcomes and dose optimization are warranted.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"9 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway. 博氏酵母菌通过Cyba和IL-17信号通路缓解卵清蛋白诱导的焦亡

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-07-31 DOI: 10.1002/mnfr.70194

Zhifeng Chen,Lang Hu,Yue Yang,Yina Wang,Yayong Li,Jing Su,Guyi Wang,Subo Gong

{"title":"Saccharomyces boulardii Alleviates Ovalbumin-Induced Pyroptosis Through Cyba and IL-17 Signaling Pathway.","authors":"Zhifeng Chen,Lang Hu,Yue Yang,Yina Wang,Yayong Li,Jing Su,Guyi Wang,Subo Gong","doi":"10.1002/mnfr.70194","DOIUrl":"https://doi.org/10.1002/mnfr.70194","url":null,"abstract":"Saccharomyces boulardii (S. boulardii), a beneficial yeast probiotic, is effective in treating asthma in children. This study aimed to examine the effects of S. boulardii on Ovalbumin (OVA)-induced pyroptosis in human bronchial epithelial cells. An OVA-induced asthma mouse model was used with S. boulardii as an intervention. S. boulardii alleviated OVA-induced lung tissue pyroptosis and intestinal tissue damage in asthmatic mice. The mRNA sequencing analysis revealed differentially expressed genes, including elevated Cyba levels in the intestinal tissues of the OVA group. However, S. boulardii reduced Cyba levels. Gene Set Enrichment analysis showed the involvement of IL-17 signaling pathway. In vivo experiments showed that S. boulardii inhibited IL-17 signaling pathway in the intestinal and lung tissues. In vitro experiments revealed that IL-17 regulation of ROS production, promoting BEAS-2B cell pyroptosis, required the involvement of Cyba. Moreover, Cyba knockdown inhibited activation of NLRC4 and NLRP3 inflammasomes induced by IL-17 in vivo. This study revealed for the first time the important role of Cyba and IL-17 pathways in asthma pathology and demonstrated that S. boulardii exerted its therapeutic effects by modulating these pathways. These findings provided a basis for developing nutrition interventions targeting gut microbiota and immune health.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"96 1","pages":"e70194"},"PeriodicalIF":5.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0