Molecular Nutrition & Food Research最新文献

{"title":"Human Milk Bioactive Compounds and Allergic- and Infectious-Related Infant Outcomes: A Systematic Review","authors":"Eduard Flores Ventura,&nbsp;Daria Guseva,&nbsp;Vanessa Hübert,&nbsp;Anna Samarra,&nbsp;Regina Ensenauer,&nbsp;Maria Carmen Collado","doi":"10.1002/mnfr.70390","DOIUrl":"10.1002/mnfr.70390","url":null,"abstract":"<p>The impact of Human Milk (HM) bioactive compounds on infant health is crucial yet complex. Current research highlights their role in immune system development and disease prevention. This review aims to synthesize existing literature on the role of HM's bioactive compounds in the onset of diagnosed allergies, immunological diseases, and responses to infectious diseases by infants and children up to 18 years. The systematic review adhered to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). A comprehensive search strategy was employed across PubMed, Web of Science, SCOPUS, Scientific Electronic Library Online (SciELO), Cochrane Library, Latin American and Caribbean Health Sciences Literature (LILACS), and LIVIVO. Quality assessment utilized Joanna Briggs Institute checklists for various study designs. Protocol: CRD42023432030. The systematic review encompassed 34 studies, published from 1983 to 2024, representing a total of 9,298 mother–infant dyads. Included studies reported that allergic-related conditions, particularly food allergy, sensitization, and atopic dermatitis, were inversely associated with HM linolenic and linoleic acid. In a meta-analysis of three studies, infants with atopic dermatitis showed lower total omega-3 levels (SMD = -0.46, 95% CI: -1.82 to -0.90, I² = 91%, p &lt; 0.01), with reduced EPA and DGLA, suggesting, but not confirming, a potential protective role of omega-3 and involvement of inflammatory pathways. Furthermore, results on infectious-related conditions, primarily diarrhoea and Group B Streptococcus (GBS) infections, suggested inverse associations with 2'-fucosyllactose (2´-FL), lacto-<i>N</i>-difucohexaose I (LDFH-I), and immunoglobulins (Anti-GBS secretory immunoglobulin A (SIgA), anti-lipopolysaccharide IgA (Anti-LPS IgA), anti-cholera toxin IgA, respectively). Results of studies on upper and lower respiratory tract infections, otitis media, and dental caries suggested inverse associations with galectins and galectin-3, lacto-<i>N</i>-tetraose (LNT), 2´-FL, and Haemophilus influenzae. Data suggest that HM bioactive compounds, such as polyunsaturated fatty acids (PUFAs), HMOs, and a number of specific immunoglobulin A (IgA) antibodies may influence allergic and infectious outcomes in infants. In pooled analyses of omega-3 levels, HM fed to infants with atopic dermatitis showed reduced EPA and DGLA. However, these pooled estimates are severely limited by high statistical heterogeneity (I² = 91%) and should be interpreted as exploratory findings. Despite of the limited overall evidence due to heterogeneity, low replication, and methodological variability, this review offers a broad synthesis of current findings and highlights key knowledge gaps, providing a foundation for future research focused on elucidating the immunological roles of understudied components, such as antimicrobial peptides, through multi-omics and longitudinal approaches.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146198647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caloric Restriction and Dietary Taurine Regulate Taurine Homeostasis Through Distinct Tissue-Specific Mechanisms in Mice","authors":"András Gregor,&nbsp;Arturo Auñon-Lopez,&nbsp;Qendrim Zebeli,&nbsp;Marc Pignitter,&nbsp;Kalina Duszka","doi":"10.1002/mnfr.70414","DOIUrl":"10.1002/mnfr.70414","url":null,"abstract":"<p>Caloric restriction (CR) stimulates taurine-conjugated bile acids (BA) synthesis in the liver. Upon secretion into the intestine, BAs undergo deconjugation, increasing taurine, and taurine conjugate levels, including taurine-glutathione (GSH). This study aimed to determine whether dietary taurine and CR-induced taurine changes operate through distinct regulatory mechanisms. Male C57Bl/6 mice were subjected to ad libitum feeding or 20% CR with low-taurine diet (LTD) or 5% taurine in drinking water. LTD and taurine supplementation minimally affected intestinal taurine concentrations and did not disrupt CR-induced changes in intestinal taurine levels, GSH conjugates, and GST expression, demonstrating mechanistic independence. Both interventions significantly altered hepatic and plasma taurine levels, indicating tissue-specific regulation. While CR primarily influenced GSH-S transferase (GST) mRNA expression in the intestine, GST activity correlated with substrate availability rather than gene expression. CR maintained enhanced intestinal taurine retention during taurine supplementation, evidenced by reduced fecal taurine excretion compared to controls. Dietary and CR-related taurine are affected by distinct tissue-specific mechanisms, with CR primarily impacting intestinal taurine while modulation of dietary taurine (restriction or supplementation) predominantly influences hepatic pools. The study reveals independent regulatory mechanisms governing taurine homeostasis and emphasizes differences between dietary factors and physiological responses during CR.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Habitual Food Intake and Energy Metabolism-Related Urine Metabolites in Female Soccer Players","authors":"Maria B. A. Nascimento,&nbsp;Maria M. S. Gouveia,&nbsp;Maryssa P. P. Dos Santos,&nbsp;Alessandre C. Crispim,&nbsp;Edmilson R. Da Rocha-Júnior,&nbsp;Edson S. Bento,&nbsp;Thiago M. Aquino,&nbsp;Nassib B. Bueno,&nbsp;Filipe A. B. Sousa,&nbsp;Gustavo G. De araújo,&nbsp;Thays Ataide-Silva","doi":"10.1002/mnfr.70389","DOIUrl":"10.1002/mnfr.70389","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>To assess the association between habitual nutrients intake and the energetic metabolism-related metabolites found by nuclear magnetic resonance (NMR) in female soccer players’ urine.Thirteen female soccer players were measured for habitual food intake 11 days before the competitive season, and had urine samples collected pre- and post-match during five matches of two simultaneous championships to be examined by NMR. Nutrients and metabolites were associated through univariate and multivariate analyses. B3, B6, Prot.kg and energy (Kcal.kg) with leucine; B1, B3, B6, energy (Kcal.kg) and Prot.kg with AHI, glucose, tyrosine; formate and 1-Methylnicotinamide. In parallel, inverse correlations were observed between B3, B6, and Prot.kg with creatinine, B12 and 1-Methylnicotinamide (<i>r</i> ≥ 0.4; <i>p</i> &lt; 0.05). In conclusion, it is possible to speculate that the herein described associations between metabolites and nutrients involved in energy metabolism seem to result from their participation in oxidative pathways, mainly in the TCA cycle and in gluconeogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Effect of Powder Bergamot Juice (Citrus bergamia Risso & Poiteau) on Pathophysiological Processes of Renal Disease in an Experimental Western Diet Model","authors":"Marina de Paula Salomé dos Santos,&nbsp;Juliana Silva Siqueira,&nbsp;Erika Tiemi Nakandakare-Maia,&nbsp;Taynara Aparecida Vieira,&nbsp;Núbia Alves Grandini,&nbsp;Thiago Luiz Novaga Palacio,&nbsp;Luís Eduardo Sormani,&nbsp;Caíque Manentti Caccia,&nbsp;Jordanna Cruzeiro,&nbsp;Fabiane Valentini Francisqueti-Ferron,&nbsp;Camila Renata Corrêa","doi":"10.1002/mnfr.70411","DOIUrl":"10.1002/mnfr.70411","url":null,"abstract":"<p>The Western diet (WD), rich in sugars and saturated fats, is linked to metabolic disturbances that contribute to chronic kidney disease (CKD). Natural antioxidants have been investigated in several diseases, including bergamot (<i>Citrus bergamia</i>), a citrus fruit rich in polyphenols with recognized antioxidant and anti-inflammatory properties. This study evaluated the preventive effect of powder bergamot juice (PBJ) on renal alterations induced by WD in male Wistar rats. Animals were allocated into four groups (<i>n</i> = 7): control diet, control + PBJ (250 mg/kg), WD; and WD + PBJ for 20 weeks. WD groups also received 25% sucrose in drinking water. Nutritional, metabolic, hormonal, renal, and oxidative stress (OS) markers were measured. Statistical analyses included two-way ANOVA/Tukey's post-hoc and Kruskal–Wallis/Dunn's post-hoc (<i>p</i> &lt; 0.05). WD increased caloric intake, body weight, adiposity index, glucose, triglycerides, and renal OS markers, and reduced kidney function. PBJ supplementation reduced adiposity and triglycerides, improved antioxidant enzyme activity, and preserved renal function. PBJ attenuated metabolic and oxidative alterations induced by WD, supporting its potential as a preventive strategy against early renal dysfunction associated with CKD.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transportome (CBLIF/TCN2) and CHRNA7 Nodes","authors":"Hajir A. Al Saihati,&nbsp;Bushra Y. Ahmed,&nbsp;Rehab M. Mosaad,&nbsp;Hoda A. S. El-Garhy,&nbsp;Rofanda M. Bakeer,&nbsp;Einas M. Yousef,&nbsp;Inas M. Ahmed,&nbsp;Walaa S. Saif El Nasr,&nbsp;Azizeh Shadi-Dizaji,&nbsp;Omar A. Ahmed-Farid,&nbsp;Mohamad Warda","doi":"10.1002/mnfr.70382","DOIUrl":"10.1002/mnfr.70382","url":null,"abstract":"<div>\u0000 \u0000 <p>Emerging evidence suggests that chronic use of gastric acid-suppressing medications may contribute to neurocognitive decline, yet the underlying mechanisms remain poorly defined. Proton pump inhibitors like omeprazole and histamine-2 receptor antagonists such as ranitidine are widely prescribed for gastrointestinal disorders, but their long-term impact on brain function. Forty-eight male Wistar rats were assigned to six groups receiving either control diet, B₁₂ alone, omeprazole, ranitidine, or co-treatment with B₁₂ for 90 days. Behavioral and cognitive assessments revealed early deficits in the drug-only-treated groups (omeprazole and ranitidine). Notably, B₁₂ ameliorated omeprazole-induced impairments but failed to reverse ranitidine-associated deficits, suggesting divergent neurotoxic pathways. Biochemical profiling included serum B₁₂, homocysteine, cortisol, glucose, insulin, liver enzymes, and neurotransmitter. To complement these in vivo findings, an in silico approach was employed to explore molecular interactions of omeprazole and ranitidine with proteins critical for vitamin B₁₂ transport (CBLIF and TCN2) and cholinergic neurotransmission (CHRNA7). Together, these in vivo and in silico results suggest that omeprazole-induced cognitive decline may involve B₁₂ depletion and other mechanisms, whereas ranitidine likely acts via alternative pathways. This study provides novel mechanistic insights into differential cognitive risks associated with chronic acid-suppressing therapy, with implications for long-term management in populations vulnerable to neurodegeneration.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Interventions With Schleiferilactobacillus harbinensis Z171, Its EPS and Postbiotics Ameliorate Cholesterol Metabolism via Modulating the Gut-Liver Axis in High-Fat Diet-Fed Mice","authors":"Mohamedelfatieh Ismael,&nbsp;Jinsong Wu,&nbsp;Huirong Yang,&nbsp;Qingping Zhong","doi":"10.1002/mnfr.70410","DOIUrl":"10.1002/mnfr.70410","url":null,"abstract":"<div>\u0000 \u0000 <p>Dietary interventions represent safe and healthy strategies for reducing cholesterol levels and improving metabolic health. This study aimed to investigate the effects of the probiotic <i>Schleiferilactobacillus harbinensis</i> Z171, its extracellular polysaccharides (EPS), and postbiotics on cholesterol metabolism in the gut of mice fed a high-fat diet. The analysis focused on total cholesterol and bile acid levels in intestinal contents and serum, as well as bile acid reabsorption, short-chain fatty acid (SCFA) levels, gut microbiota composition, and metabolomic profiles. The results showed that high-dose EPS (400 mg/kg body weight), live <i>S. harbinensis</i> Z171, and postbiotics significantly increased fecal bile acid excretion to 86.49, 79.94, and 85.20 µmol/L, and SCFA production to 33.12, 28.71, and 29.01 µmol/g, respectively. Conversely, they decreased fecal cholesterol levels to 7.96, 8.26, and 5.93 µmol/L, respectively. Fecal metabolomics revealed an enrichment of metabolites related to bile acid biosynthesis. Gut microbiota analysis showed an increase in beneficial bacterial species associated with SCFA production, which improved lipid metabolism and gut health. Specifically, high-dose EPS enriched <i>Faecalibaculum</i> and <i>Enterorhabdus</i> in the gut, <i>S. harbinensis</i> Z171 increased <i>Bifidobacterium</i> abundance, and postbiotics elevated <i>Dubosiella</i> and <i>Akkermansia</i> levels. These findings suggest these interventions are promising strategies for regulating cholesterol metabolism through gut-liver axis mechanisms.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effects of Probiotic Mediated Digested Gliadin and 33-mer Peptide in Caco-2 Cell Cultures","authors":"Anjali Jaglan,&nbsp;Gunjan Sadera,&nbsp;Anju Nagpal,&nbsp;Payal S. Mate,&nbsp;Sudarshan Kumar,&nbsp;Gunjan Goel","doi":"10.1002/mnfr.70367","DOIUrl":"10.1002/mnfr.70367","url":null,"abstract":"<div>\u0000 \u0000 <p>Gluten protein generates an immunogenic 33-mer peptide upon incomplete digestion, leading to induced cytotoxic and inflammatory responses in intestinal epithelial cells of susceptible individuals with Celiac disease (CeD). The present study investigates the protective effects of gluten hydrolyzing probiotic strains—<i>Bacillus subtilis</i> AJG10 and <i>Bacillus tequilensis</i> AJG23 on gliadin and 33-mer peptide in the Caco-2 cell model. The effect of probiotics on further degradation of 33-mer peptide and pepsin-trypsin digested gliadin was analysed using SDS-PAGE and mass spectrometry. The effect of all fractions on Caco-2 cell viability, nitric oxide (NO) production, and expression of pro-inflammatory cytokines was evaluated. A significant degradation of immunogenic peptide fragments after probiotic treatments resulted in 44%–53% reduction in NO production and a decrease of 27%–37% in cytokine expression and overall improvement in cell viability. The results suggested the potential of probiotic interventions in reducing the toxic effects of digested gliadin and immunogenic peptides.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Butyrate Supplementation with Cardiovascular Disease:A Narrative Review","authors":"Song-jie Han,&nbsp;Jian-lin Wei,&nbsp;Qian-qian Xu,&nbsp;Xiao-hong Wei,&nbsp;Hongcai Shang","doi":"10.1002/mnfr.70374","DOIUrl":"10.1002/mnfr.70374","url":null,"abstract":"<div>\u0000 \u0000 <p>Cardiovascular diseases (CVDs) have long been a significant source of the global disease burden and a leading cause of death and disability. In recent years, the precise microbiome modulation of the gut has made remarkable progress as a new strategy for treating CVDs, especially its production of short-chain fatty acids, the primary way the gut flora affects the organism. Butyrate, one of the critical metabolites of short-chain fatty acids, butyrate uniquely restores intestinal barrier function, suppresses systemic inflammation, promotes immune tolerance, and regulates energy metabolism while antagonizing the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO) via the gut–heart axis. Preclinical studies consistently show that butyrate supplementation mitigates heart failure (HF), atherosclerosis, myocardial infarction, hypertrophic cardiomyopathy, hypertension, and cancer-related cardiac injury, and concurrently ameliorates metabolic syndrome, dyslipidaemia, and hyperglycaemia. However, clinical translation is currently hampered by a lack of large-scale human randomized controlled trials (RCTs) and an insufficient understanding of human dose-response relationships. This review synthesizes knowledge on butyrate's cardiovascular actions, details the underlying mechanisms, and highlights critical evidence gaps to inform future translational research.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicon-Enriched Restructured Meat Mitigates Metabolic Dysfunction-Associated Steatohepatitis in a Late-Stage Type 2 Diabetes Mellitus Rat Model","authors":"Rocío Redondo-Castillejo,&nbsp;Marina Hernández-Martín,&nbsp;Aránzazu Bocanegra,&nbsp;Adrián Macho-González,&nbsp;Rosa A. García-Fernández,&nbsp;Luis Apaza Ticona,&nbsp;Sara Bastida,&nbsp;Francisco J. Sánchez-Muniz,&nbsp;María Elvira López-Oliva,&nbsp;Alba Garcimartín,&nbsp;Juana Benedí","doi":"10.1002/mnfr.70404","DOIUrl":"10.1002/mnfr.70404","url":null,"abstract":"<div>\u0000 \u0000 <p>Functional foods with antidiabetic and lipid-lowering properties may serve as a nutritional strategy for metabolic dysfunction-associated steatohepatitis (MASH), especially when coexisting with type 2 diabetes mellitus (T2DM). This study evaluates whether the consumption of silicon-enriched restructured meat (Si-RM) could alleviate hepatic injury and metabolic disturbances in a late-stage T2DM rat model. Early-stage (ED, <i>n</i> = 8) and late-stage (LD, <i>n</i> = 16) T2DM were induced following a high-saturated-fat diet or a high-saturated-fat, high-cholesterol diet plus streptozotocin/nicotinamide injection, respectively, both diets containing a control meat. After confirming hyperglycemia, half of LD rats received Si-RM for 5 weeks (LD-Si, <i>n</i> = 8). Metabolic indices, liver histology, oxysterols, hepatic ChREBP/SREBP-1c, proliferation/apoptosis balance, and antioxidant defenses were assessed. LD rats developed clear histopathological and biochemical MASH. Si-RM consumption partially ameliorated these alterations, showing reduced lobular inflammation, improved serum oxysterol profile (decreased 25- and 27-hydroxycholesterols, increased 7-hydroxylated cholesterols), downregulated hepatic ChREBP, restored SREBP-1c, rebalanced proliferation to apoptosis ratio, and enhanced antioxidant defenses. Si-RM mitigated MASH severity and improved hepatic oxidative and metabolic status in a late-stage T2DM. These findings support the therapeutic potential of Si-RM as a promising and accessible nutritional adjuvant strategy against MASH.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of GAPDH as an Allergen in Allium Mongolicum Regel and Its Pro-Inflammatory Effects on respiratory and Intestinal Epithelia","authors":"Xiaoyan Wang,&nbsp;Yang Liu,&nbsp;Dongmei Zhou,&nbsp;Yuanfen Liao,&nbsp;Ximeng Ma,&nbsp;Xinhui Gong,&nbsp;Qi Cheng,&nbsp;Xueyan Wang,&nbsp;Yubao Cui","doi":"10.1002/mnfr.70405","DOIUrl":"10.1002/mnfr.70405","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Allium mongolicum</i> Regel (AMR), a traditional edible and medicinal herb widely consumed in Asian cuisines, presents an important but understudied food safety concern due to its allergenic potential. This study bridges the gap between food science and health impacts by characterizing the first major allergen in AMR. Through an integrated approach combining transcriptome sequencing and immunological techniques, we identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a novel food allergen. The recombinant GAPDH protein exhibited clinically relevant IgE reactivity in 48.1% (13/27) of allergic individuals' sera, establishing its role in food allergy. Notably, we demonstrated that this food-derived allergen triggers distinct inflammatory pathways in human gastrointestinal (Caco-2) and respiratory (BEAS-2B) epithelial cells—key interfaces for food-host interactions. Transcriptomic analysis revealed tissue-specific responses: intestinal cells upregulated immunemodulatory genes (EPHB1, CD226, CD59), while lung cells activated interferon signaling, offering theoretical explanations for how dietary components may influence mucosal immunity. These findings significantly advance our understanding of herbal food allergies and pave the way for developing safer functional foods and targeted allergy management strategies.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 3","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}