Molecular Nutrition & Food Research最新文献_第8页

Palliative Effects of Phenolic, Polysaccharide, and Lipid Extracts of Hulless Barley Grass on Acute Ulcerative Colitis 大麦草酚、多糖和脂质提取物对急性溃疡性结肠炎的缓解作用。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-28 DOI: 10.1002/mnfr.70401

Zhiqian Wu, Mingming Wang, Xiaoning Liu, Harold Corke, Wuyang Huang, Zhongquan Sui

{"title":"Palliative Effects of Phenolic, Polysaccharide, and Lipid Extracts of Hulless Barley Grass on Acute Ulcerative Colitis","authors":"Zhiqian Wu, Mingming Wang, Xiaoning Liu, Harold Corke, Wuyang Huang, Zhongquan Sui","doi":"10.1002/mnfr.70401","DOIUrl":"10.1002/mnfr.70401","url":null,"abstract":"<div>\u0000 \u0000 Hulless barley grass (HBG) is rich in bioactive compounds such as phenolics, polysaccharides, and lipids, and consequently possesses antioxidant, anti-inflammatory, and anti-tumor properties. However, which components contribute to its potential palliative effect on acute ulcerative colitis (AUC) is unknown. In this study, phenolics, polysaccharides, and lipids were extracted separately from HBG, and their antioxidant activities and effects on AUC in vivo were investigated. Compared to the polysaccharide/lipid extracts, phenolic extracts (HBGPE) had much higher antioxidant capacity, with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenging capacity of 1.34 ± 0.02 mmol Trolox/100 g. The HBGPE also significantly decreased the body weight loss and colonic condition of dextran sodium sulfate (DSS)-induced AUC mice. The strong anti-inflammatory effects of HBGPE led to a significant reduction in the degree of inflammatory cell infiltration, crypt structure disruption, and mucosal damage, and down-regulated the mRNA expression of tumor necrosis factor (Tnfα), interleukin-6 (Il6), and Il1b. In addition, HBGPE could reduce intestinal flora disorders. Both polysaccharide and lipid extracts led to little reduction in the colon inflammatory condition. This study confirmed that HBG extracts could inhibit inflammatory response, oxidative stress, and gut microbial imbalance, especially HBGPE, which indicated that HBG may have potential for application in dietary prevention of AUC.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Tannic Acid on Gut Microbiota and Metabolomics in Mice with Type 2 Diabetes 单宁酸对2型糖尿病小鼠肠道菌群和代谢组学的影响

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-28 DOI: 10.1002/mnfr.70416

Qiming Miao, Xueying Geng, Yuyang Yao, Congcong Yu, Jing Zhang, Haiyan Bai, Junxia Guo, Yanzhen Zhang, Shengquan Mi

{"title":"Effects of Tannic Acid on Gut Microbiota and Metabolomics in Mice with Type 2 Diabetes","authors":"Qiming Miao, Xueying Geng, Yuyang Yao, Congcong Yu, Jing Zhang, Haiyan Bai, Junxia Guo, Yanzhen Zhang, Shengquan Mi","doi":"10.1002/mnfr.70416","DOIUrl":"10.1002/mnfr.70416","url":null,"abstract":"<div>\u0000 \u0000 Tannin, a mixture of polyphenols, has been shown to possess various pharmacological activities, including antitumor, hypolipidemic, and hypoglycemic effects. Currently, tannic acid has demonstrated beneficial effects in improving the streptozotocin-induced type2 diabetes model. However, the specific mechanisms by which tannic acid lowers blood glucose through modulation of the gut microbiota and metabolomics remain to be fully elucidated. This study investigated the therapeutic effect of tannic acid from Galla Chinensis on mice with type 2 diabetes (T2D) induced by a high-fat diet (HFD) and streptozotocin (STZ). To explore the potential mechanisms, we conducted 16S diversity analysis of gut microbiota and non-targeted metabolomics analysis. Our findings demonstrate that appropriate administration of tannic acid significantly reduces fasting blood glucose levels and alleviates pathological changes in the liver and islets. The results indicate that tannic acid promotes the growth of beneficial bacteria and inhibits harmful bacteria. Furthermore, tannic acid improves diabetes and its complications mainly through glycerolphospholipid metabolism and arachidonic acid metabolism.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotinamide Riboside Alleviates Heat Stress-Induced Intestinal Dysfunction by Enhancing Antioxidant Capacity, Restoring Immune Homeostasis, and Modulating Gut Microbiota in a Boar Model 在猪模型中，烟酰胺核苷通过增强抗氧化能力、恢复免疫稳态和调节肠道微生物群来缓解热应激诱导的肠道功能障碍。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-28 DOI: 10.1002/mnfr.70418

Xianyang Jin, Xihao Luo, Wenxue Shen, Gang Lv, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Yong Zhuo, De Wu, Lun Hua

{"title":"Nicotinamide Riboside Alleviates Heat Stress-Induced Intestinal Dysfunction by Enhancing Antioxidant Capacity, Restoring Immune Homeostasis, and Modulating Gut Microbiota in a Boar Model","authors":"Xianyang Jin, Xihao Luo, Wenxue Shen, Gang Lv, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Shengyu Xu, Yan Lin, Yong Zhuo, De Wu, Lun Hua","doi":"10.1002/mnfr.70418","DOIUrl":"10.1002/mnfr.70418","url":null,"abstract":"<div>\u0000 \u0000 Heat stress (HS) induces adverse intestinal effects, including morphological damage, immune dysfunction, and microbial dysbiosis. Nicotinamide riboside (NR) supplementation has shown promise in protecting against intestinal injury. This study aimed to investigate the efficacy of NR in alleviating HS-induced intestinal damage in a porcine model. Eighteen boars were randomized into three groups (n = 6): control (CON, thermoneutral), heat stress (HS), and HS with NR supplementation (HS-NR). After an initial feeding phase, the HS and HS-NR groups were exposed to an HS environment (35 ± 1°C) for 2 weeks, while the CON group remained thermoneutral. Intestinal injury was assessed via histomorphology, biochemical parameters, transcriptomics, and microbiome sequencing. We found that NR supplementation significantly restored intestinal morphology and attenuated colonic oxidative stress compared to the HS group. Moreover, NR ameliorated HS-induced immune dysfunction and corrected gut microbial dysbiosis. These results suggest the therapeutic potential of NR as a nutritional intervention to mitigate HS-induced intestinal damage.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Regulation of the BDNF Gene by Molybdenum in 9 to 11-Year-Old Children: A Targeted Gene DNA Methylation Study 钼对9 ~ 11岁儿童BDNF基因的表观遗传调控：一项靶向基因DNA甲基化研究

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-26 DOI: 10.1002/mnfr.70426

Margaret A. Voss, Stefanie R. Pilkay, Dustin T. Hill, Lynn S. Brann, Kestutis Bendinskas, Patrick J. Parsons, Christopher D. Palmer, Brooks B. Gump

{"title":"Epigenetic Regulation of the BDNF Gene by Molybdenum in 9 to 11-Year-Old Children: A Targeted Gene DNA Methylation Study","authors":"Margaret A. Voss, Stefanie R. Pilkay, Dustin T. Hill, Lynn S. Brann, Kestutis Bendinskas, Patrick J. Parsons, Christopher D. Palmer, Brooks B. Gump","doi":"10.1002/mnfr.70426","DOIUrl":"10.1002/mnfr.70426","url":null,"abstract":"While essential trace minerals are known to influence DNA methylation (DNAm), molybdenum's (Mo) role in epigenetic regulation remains largely unexplored. This study examined associations between Mo status and DNAm of the brain-derived neurotrophic factor (BDNF) gene, a critical regulator of neurogenesis, in children aged 9–11 years, focusing on 107 CpG sites across BDNF and its antisense transcript (BDNF-AS).BDNF and BDNF-AS methylation was analyzed in blood samples from 72 children randomly selected from a cohort of 292 participants. Dietary Mo intake was estimated from food records, and creatinine-adjusted urinary Mo levels were quantified. Higher urinary molybdenum was significantly associated with decreased methylation at five BDNF 5'UTR sites (p<.05) and increased methylation of BDNF-AS (p = .0001), consistent with enhanced BDNF transcriptional activity. African American children exhibited lower urinary Mo excretion than European American children, suggesting greater retention, and showed cortisol-associated increases in BDNF methylation not observed in European American children.These findings demonstrate associations between molybdenum status and DNA methylation patterns at the BDNF locus in children. While functional validation through BDNF protein measurement is needed, results suggest molybdenum may influence neurotrophin gene regulation through epigenetic mechanisms, highlighting the importance of trace mineral nutrition during neurodevelopment.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 5","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12946595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thymoquinone-Coenzyme Q10 Combination Therapy Ameliorates Post-Spinal Cord Injury Osteoporosis Through Enhanced Wnt/β-Catenin Signaling and Antioxidant Defense 百里醌-辅酶Q10联合治疗通过增强Wnt/β-Catenin信号和抗氧化防御改善脊髓损伤后骨质疏松症

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-25 DOI: 10.1002/mnfr.70402

JiZu Tang, Shan Zhou, Feng Xiong, Wenyan Hu

{"title":"Thymoquinone-Coenzyme Q10 Combination Therapy Ameliorates Post-Spinal Cord Injury Osteoporosis Through Enhanced Wnt/β-Catenin Signaling and Antioxidant Defense","authors":"JiZu Tang, Shan Zhou, Feng Xiong, Wenyan Hu","doi":"10.1002/mnfr.70402","DOIUrl":"10.1002/mnfr.70402","url":null,"abstract":"<div>\u0000 \u0000 Spinal cord injury (SCI) results in rapid bone loss and osteoporosis development. This study investigated the synergistic effects of a combination of thymoquinone (TQ) and coenzyme Q10 (CoQ10) on SCI-induced osteoporosis. Thirty male Wistar rats underwent complete spinal cord transection at T10 and were divided into five groups: sham, untreated SCI, TQ-treated (100 mg/kg/day), CoQ10-treated (10 mg/kg/day), and combination therapy (TQ + CoQ10). After 21 days of treatment, combination therapy significantly improved BBB locomotor scores (12.1 ± 0.7 vs. 2.1±0.4 in untreated SCI; p < 0.001) and increased femoral BMD and BMC by 32.8% and 37.9%, respectively. Micro-CT analysis revealed 45.2% higher bone volume/total volume ratio and enhanced trabecular architecture. The combination therapy significantly downregulated SOST expression (76.2% reduction) while upregulating periostin (184.7% increase). Osteoclast markers decreased (CTR: 57.3%, cathepsin K: 63.1%) while osteoblast markers increased (ALP: 143.8%, osterix: 127.4%). Oxidative stress markers improved substantially, with 47.3% lower MDA levels and 86.5% higher SOD activity. TQ + CoQ10 combination therapy produces both synergistic and additive effects that ameliorates SCI-induced osteoporosis in association with altered expression of Wnt/β-catenin signaling components, enhancing bone formation, and reducing oxidative stress, demonstrating superior therapeutic efficacy compared to monotherapies.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-Specific Renal Proteomic Responses to Mycotoxins and Their Mitigation by Bioactive Food Ingredients 对真菌毒素的性别特异性肾脏蛋白质组反应及其生物活性食品成分的缓解作用。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-24 DOI: 10.1002/mnfr.70417

Fojan Agahi, Alessandra Cimbalo, Lara Manyes

{"title":"Sex-Specific Renal Proteomic Responses to Mycotoxins and Their Mitigation by Bioactive Food Ingredients","authors":"Fojan Agahi, Alessandra Cimbalo, Lara Manyes","doi":"10.1002/mnfr.70417","DOIUrl":"10.1002/mnfr.70417","url":null,"abstract":"This study aimed to evaluate sex-related differences in kidney toxicity induced by aflatoxin B1 (AFB1) and ochratoxin A (OTA), administered either individually or in combination, and to investigate the mitigating potential of fermented whey (FW) and pumpkin (P) using a proteomic approach in a sub-chronic rat model. Diets naturally contaminated with AFB1 and OTA fungal producers, or enriched with FW and P, were administered to 120 Wistar rats for 28 days. Afterwards, kidneys were collected and subjected to protein extraction and digestion to peptides. For proteomic analysis, peptides were separated using an LC–QTOF–MS system, and differentially expressed proteins between control and treated groups were statistically filtered (p < 0.05) to distinguish sex-related differences between males and females. Proteomic analysis revealed that non-supplemented diets induced significant protein alterations, with male kidneys showing greater sensitivity to mycotoxin exposure, particularly to OTA, and exhibiting a distinct expression pattern compared with females. Notably, FW and FW + P supplementation mitigated these adverse effects by reducing the number of differentially expressed proteins, stabilizing mitochondrial function, and enhancing xenobiotic metabolism pathways. These findings underscore the importance of sex-specific factors in evaluating the protective potential of bioactive ingredients against mycotoxin-induced renal injury.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12933019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147281046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus 2型糖尿病中双曲下垂的机制作用。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-23 DOI: 10.1002/mnfr.70424

Danqi Zou, Yanping Zou, Yujie Jin, Shilin Liu, Minghao Lin, Ruixue Deng, Zheng Nan

{"title":"Mechanistic Role of Disulfidptosis in Type 2 Diabetes Mellitus","authors":"Danqi Zou, Yanping Zou, Yujie Jin, Shilin Liu, Minghao Lin, Ruixue Deng, Zheng Nan","doi":"10.1002/mnfr.70424","DOIUrl":"10.1002/mnfr.70424","url":null,"abstract":"Disulfidptosis is a newly identified form of regulated cell death. It occurs under glucose-starvation conditions and is characterized by metabolic dysregulation in cells with high expression of SLC7A11. Increased cystine uptake under these conditions leads to depletion of NADPH, ultimately triggering cell death. Current research on disulfidptosis has mainly focused on malignant tumors. However, the critical factors involved in disulfidptosis, including high SLC7A11 expression and NADPH depletion, may have potential relevance to type 2 diabetes mellitus (T2DM). Both insulin secretion and insulin resistance are regulated by NADPH levels, and SLC7A11 also plays a key role in glucose metabolism through maintaining redox homeostasis. Although the direct connection between disulfidptosis and T2DM remains to be experimentally verified, this review integrates existing studies to systematically examine their theoretical relationship from both mechanistic and therapeutic perspectives. It focuses on the roles of SLC7A11, NADPH, and other related factors in T2DM and its complications, aiming to provide a theoretical basis for developing new treatment strategies for diabetes.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perinatal High-Fat Diet Induces Vascular Hypercontractility via DNA Hypomethylation of Endothelin Receptors and PKC-LTCC Axis Activation in Male Offspring 围产期高脂饮食通过内皮素受体DNA低甲基化和PKC - LTCC轴激活诱导雄性后代血管过度收缩

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-22 DOI: 10.1002/mnfr.70415

Qiutong Zheng, Huamei Jian, Qinyuan He, Eryun Zhang, Xiaomin Zheng, Ying Chen, Zhice Xu

{"title":"Perinatal High-Fat Diet Induces Vascular Hypercontractility via DNA Hypomethylation of Endothelin Receptors and PKC-LTCC Axis Activation in Male Offspring","authors":"Qiutong Zheng, Huamei Jian, Qinyuan He, Eryun Zhang, Xiaomin Zheng, Ying Chen, Zhice Xu","doi":"10.1002/mnfr.70415","DOIUrl":"10.1002/mnfr.70415","url":null,"abstract":"<div>\u0000 \u0000 Excessive fat intake is a well-established risk for hypertension; perinatal nutritional imbalances could increase vascular risks, but underlying mechanisms remain unclear. Endothelin-1 (ET-1), a potent vasoconstrictor, is implicated in cardiovascular diseases. This study aimed to address this gap by investigating ET-1 receptor-mediated pathways with high-fat-diet (HFD) during pregnancy and lactation. Vascular function, Ca2+ signaling, molecular expression, and DNA methylation were assessed in mesenteric arteries (MA) of offspring. HFD offspring exhibited increased fetal/adult weight, thickened MA wall, and enhanced ET-1-mediated vasoconstriction. Mechanistically, perinatal HFD upregulated ET-1 receptors (ETAR/ETBR) via hypomethylation of their gene promoters (Ednra/Ednrb), which augmented ET-1-induced Ca2+ currents, fluorescence Ca2+ transients, and vascular tone. Which relied on the PKC-LTCC axis (strengthened by PKC activator and LTCC agonist) and altered intracellular Ca2+ handling (via ryanodine receptors and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase), but were independent of IP3 receptors. ETAR/ETBR blockers attenuated the hypercontractility, confirming receptor-mediated effects. This is the first study to reveal that perinatal HFD persistently enhances vascular re-activity via DNA hypomethylation of ET receptors and PKC-LTCC axis. These findings not only reveal a mechanism linking perinatal HFD to adult vascular hypercontractility but also highlight ET receptors and DNA methylation as potential targets for early intervention of developmental origins of cardiovascular disease.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data 黄腐酚在人体内的生物利用度及配方和剂量的影响：随机对照试验数据

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-22 DOI: 10.1002/mnfr.70413

Sara Brehmer-Henkel, Christina Diekmann, Marit Eickeler, Ronja Maris, Christina Kopp, Martin Coenen, Robert Németh, Birgit Stoffel-Wagner, Nadine Sus, Jan Frank, Sarah Egert

{"title":"The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data","authors":"Sara Brehmer-Henkel, Christina Diekmann, Marit Eickeler, Ronja Maris, Christina Kopp, Martin Coenen, Robert Németh, Birgit Stoffel-Wagner, Nadine Sus, Jan Frank, Sarah Egert","doi":"10.1002/mnfr.70413","DOIUrl":"10.1002/mnfr.70413","url":null,"abstract":"Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting (t0), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration–time curve (AUC) (p < 0.001) and maximum plasma concentration (p <0.001). Both formulations showed a dose-dependent increase in xanthohumol maximum concentrations and AUC. The bioavailability was mainly influenced by micellation (p <0.001) and was approx. 9-fold higher after intake of micellar xanthohumol than after intake of the native form, irrespective of the dose (p = 0.480). A subsequent randomized placebo-controlled crossover bioactivity trial showed no acute effects of 172 mg micellar xanthohumol on resting energy expenditure, blood pressure, or heart rate. To conclude, bioavailability was significantly higher after ingestion of micellar xanthohumol than after ingestion of native xanthohumol.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 4","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 4'26 发布信息：Mol. Nutr。Food Res. 4'26

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-02-17 DOI: 10.1002/mnfr.70419

引用次数: 0