Molecular Nutrition & Food Research最新文献_第8页

Dietary Blueberry Supplementation Attenuates the Effects of an Ultra-Processed Food Cafeteria Diet on Weight Gain and Metabolic Parameters, Enhancing Nutrigenomic Profiles in C57BL/6 Mice. 在C57BL/6小鼠中，膳食中添加蓝莓可以减弱超加工食品自助饮食对体重增加和代谢参数的影响，增强营养基因组谱。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-22 DOI: 10.1002/mnfr.70206

Felipe Mateus Pellenz, Mayara Souza de Oliveira, Shiva Cerutti Witteé, Joana Raquel Nunes Lemos, Bianca Gomes Panis, Isadora Cristina Godoy de Lima, Celina Fagundes da Silva, Anna Carolina Meireles Vieira, Mariana Rauback Aubin, Luciane Moretto, Monique Banik Siqueira, Eliandra Girardi, Raif Gregorio Nasre-Nasser, Karla Suzana Moresco, Letícia de Almeida Brondani, Guilherme Coutinho Kullmann Duarte, Rafael Aguiar Marschner, Bianca Marmontel de Souza, Daisy Crispim

{"title":"Dietary Blueberry Supplementation Attenuates the Effects of an Ultra-Processed Food Cafeteria Diet on Weight Gain and Metabolic Parameters, Enhancing Nutrigenomic Profiles in C57BL/6 Mice.","authors":"Felipe Mateus Pellenz, Mayara Souza de Oliveira, Shiva Cerutti Witteé, Joana Raquel Nunes Lemos, Bianca Gomes Panis, Isadora Cristina Godoy de Lima, Celina Fagundes da Silva, Anna Carolina Meireles Vieira, Mariana Rauback Aubin, Luciane Moretto, Monique Banik Siqueira, Eliandra Girardi, Raif Gregorio Nasre-Nasser, Karla Suzana Moresco, Letícia de Almeida Brondani, Guilherme Coutinho Kullmann Duarte, Rafael Aguiar Marschner, Bianca Marmontel de Souza, Daisy Crispim","doi":"10.1002/mnfr.70206","DOIUrl":"https://doi.org/10.1002/mnfr.70206","url":null,"abstract":"The cafeteria diet (CAFD) model mimics Western dietary patterns, inducing obesity in mice. Blueberry (BB) consumption improves metabolic outcomes due to its anti-inflammatory and antioxidant properties, though mechanisms remain unclear. This study assessed BB supplementation effects on biometric, metabolic, and hepatic steatosis parameters in CAFD-fed mice, and analyzed obesity-related gene expression in adipose tissues, liver, muscle, and hypothalamus. Thirty-two male C57BL/6 mice were divided into three groups: Control (C, standard diet-SD; N = 10), CAF (CAFD + SD; N = 12), and BB (SD + CAFD + BB; N = 10). BB animals received 22.4 g of freeze-dried BB per week. After 16 weeks, biometric and glycemic parameters, insulin resistance (IR), hepatic steatosis, oxidative stress markers, and serum leptin, adiponectin, and irisin levels were evaluated. Expression of genes related to apoptosis, lipid and glucose metabolism, oxidative stress, and adipocytokine pathways was analyzed by qPCR. BB supplementation improved biometric, glycemic, IR, hepatic steatosis, and oxidative stress and antioxidant markers compared to CAF. Leptin, adiponectin, and irisin levels decreased in BB mice. Also, BB consumption modulated the expression of obesity-related genes. BB mitigated CAFD-induced weight gain, IR, hepatic steatosis, oxidative stress, and obesity-related gene dysregulation, highlighting its nutrigenomic potential.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70206"},"PeriodicalIF":4.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 16'25 发布信息：Mol. Nutr。Food Res. 16'25

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-22 DOI: 10.1002/mnfr.70200

引用次数: 0

Pharmacokinetics, Tissue Distribution, and Metabolic Profile of Cyanidin 3-O-β-Galactoside Purified From Black Chokeberry. 黑樱桃花青素3-O-β-半乳糖苷的药代动力学、组织分布和代谢特征。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-21 DOI: 10.1002/mnfr.70219

Xiaoyu Liu, Zhuoyan Fan, Wanlong Lu, Lei Zhang, Kexi Ma, Xinquan Yang, Jingming Li

{"title":"Pharmacokinetics, Tissue Distribution, and Metabolic Profile of Cyanidin 3-O-β-Galactoside Purified From Black Chokeberry.","authors":"Xiaoyu Liu, Zhuoyan Fan, Wanlong Lu, Lei Zhang, Kexi Ma, Xinquan Yang, Jingming Li","doi":"10.1002/mnfr.70219","DOIUrl":"https://doi.org/10.1002/mnfr.70219","url":null,"abstract":"Neurodegenerative diseases (NDs) pose a significant public health concern due to their association with cognitive impairment and disrupted brain glucose metabolism. Cyanidin 3-O-β-galactoside (Cy3Gal), an anthocyanin from black chokeberry, exerted neuroprotective effects by modulating brain energy metabolism. This study aims to investigate its absorption, tissue distribution, and metabolic profile. Following a single-dose administration (gavage, 300 mg/kg) to male Sprague-Dawley rats, Cy3Gal reached a peak plasma concentration of 2967.29 ± 556.71 ng/mL within 0.25 h. Pharmacokinetic analysis revealed a short half-life (0.77 ± 0.05 h) and high clearance rate (101.84 ± 23.90 L/h/kg), suggesting a fast distribution and elimination. Twenty metabolites were identified in plasma, including methylated, glucuronidated, and sulfated forms, with varying distribution across rat tissues. Notably, this is the first study to demonstrate that Cy3Gal and its methylated metabolites (peonidin 3-O-galactoside [Peo3Gal]) can cross the blood-brain barrier, which provided strong evidence for the neuroprotective effects. Peo3Gal showed superior protection against high glucose-induced injury compared to Cy3Gal. Additionally, in vitro fermentation with rat gut microbiota uncovered three Cy3Gal-derived metabolites, suggesting microbial involvement in its transformation. Overall, these findings provide critical insights into Cy3Gal's bioavailability and brain accessibility, supporting its potential as a dietary neuroprotective agent.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70219"},"PeriodicalIF":4.2,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Ethanol Extract of Rosa rugosa Thunb. on Ear Edema. 荆刺乙醇提取物的药效研究。关于耳水肿。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-20 DOI: 10.1002/mnfr.70214

Seon Gyeong Bak, Nisansala Chandimali, Eun Jae Park, Seung Woong Lee, Jaehoon Bae, Mun-Chual Rho, Seung Jae Lee

{"title":"Effectiveness of Ethanol Extract of Rosa rugosa Thunb. on Ear Edema.","authors":"Seon Gyeong Bak, Nisansala Chandimali, Eun Jae Park, Seung Woong Lee, Jaehoon Bae, Mun-Chual Rho, Seung Jae Lee","doi":"10.1002/mnfr.70214","DOIUrl":"10.1002/mnfr.70214","url":null,"abstract":"This study investigated the anti-inflammatory and skin barrier-restoring effects of a 50% ethanol extract of Rosa rugosa Thunb. (RT50) using both in vitro and in vivo models, including HaCaT keratinocytes and a 1-Chloro-2,4-dinitrobenzene (DNCB)-induced ear edema mouse model. The aim was to evaluate the potential efficacy of RT50 in treating hypersensitivity-related skin conditions, such as atopic and contact dermatitis, and to explore natural therapeutic alternatives with fewer side effects for managing inflammatory skin diseases. Cytotoxicity testing identified non-toxic concentrations of 10, 30, and 60 µg/mL for further analysis. RT50 significantly reduced tumor necrosis factor-α/interferon-γ-induced pro-inflammatory cytokines and chemokines in HaCaT cells, demonstrating its anti-inflammatory properties. In vivo, treatment with RT50 significantly reduced DNCB-induced ear edema, as confirmed by histological analysis. Epidermal and dermal thickness and mast cell infiltration were reduced in a concentration-dependent manner. Serum analysis showed that RT50 decreased elevated levels of Immunoglobulin E/Immunoglobulin G caused by DNCB exposure. The gene expression results further showed that RT50 suppressed DNCB-induced pro-inflammatory cytokines and chemokines in ear tissues. Additionally, RT50 restored skin barrier integrity, which was disrupted by DNCB. Key skin barrier proteins, including filaggrin, involucrin, and loricrin, showed increased expression after RT50 treatment. Factors associated with tight junctions were also positively affected, suggesting that RT50 may play a key role in repairing skin barrier function. These findings highlight RT50 as a promising therapeutic candidate for addressing inflammatory skin conditions by both reducing inflammation and restoring skin barrier integrity.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70214"},"PeriodicalIF":4.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red Meat Diet Exacerbates Colitis by Promoting the Accumulation of Myeloid Cells and Disrupting Gut Microbiota. 红肉饮食通过促进骨髓细胞的积累和破坏肠道微生物群而加剧结肠炎。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-19 DOI: 10.1002/mnfr.70203

Shiyang Huang, Kun Yang, Dongfang Sun, Lehan Pan, Lina Ma, Mingyang Li, Wen Shi, Ye Zong, Zhongtao Zhang, Chunbao Li, Yingchi Yang, Dong Zhang, Dan Tian

{"title":"Red Meat Diet Exacerbates Colitis by Promoting the Accumulation of Myeloid Cells and Disrupting Gut Microbiota.","authors":"Shiyang Huang, Kun Yang, Dongfang Sun, Lehan Pan, Lina Ma, Mingyang Li, Wen Shi, Ye Zong, Zhongtao Zhang, Chunbao Li, Yingchi Yang, Dong Zhang, Dan Tian","doi":"10.1002/mnfr.70203","DOIUrl":"10.1002/mnfr.70203","url":null,"abstract":"Inflammatory bowel disease (IBD) poses a significant threat to public health, yet its exact etiology remains unclear. Epidemiological studies reveal a strong correlation between red meat consumption and the development of IBD. In this study, we aimed to determine whether intake of different red meats increased colitis sensitivity and to explore the underlying mechanisms. Mice were fed various kinds of red meats including pork, beef, and mutton, for 2 weeks, followed by colitis induced with 2.5% dextran sulfate sodium. We found that intakes of three red meat diets (RMDs) exacerbated colonic inflammation. Transcriptome sequencing and flow cytometry analyses revealed a significant upregulation of pro-inflammatory cytokines and the infiltration of neutrophils and macrophages in the colon of mice fed RMDs. Our findings indicated that red meat consumption resulted in dysbiosis of the intestinal microbiota, marked by a decrease in the relative abundance of Streptococcus, Akkermansia, Faecalibacterium, and Lactococcus, coupled with an increase in Clostridium and Mucispirillum. These results highlight the necessity of dietary optimization, particularly the reduction of red meat consumption, as a preventive strategy against the development of IBD.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70203"},"PeriodicalIF":4.2,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaempferol: A Dietary Flavonoid with Potential Protective Effects Against Kidney Diseases. 山奈酚：一种对肾脏疾病具有潜在保护作用的膳食类黄酮。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-18 DOI: 10.1002/mnfr.70211

Jialu Shi, Jiabin Wu, Xiaoyu Zhou, Liru Zeng, Xiao Huang, Wenhong Wang

{"title":"Kaempferol: A Dietary Flavonoid with Potential Protective Effects Against Kidney Diseases.","authors":"Jialu Shi, Jiabin Wu, Xiaoyu Zhou, Liru Zeng, Xiao Huang, Wenhong Wang","doi":"10.1002/mnfr.70211","DOIUrl":"https://doi.org/10.1002/mnfr.70211","url":null,"abstract":"Globally, kidney diseases represent a significant public health challenge, with high mortality rates and a considerable threat to human health. Despite the widespread use of pharmacological treatments, renal dialysis, and renal transplantation in the treatment of kidney diseases, these approaches often fail to address patients' therapeutic needs fully. As a result, the development of novel preventive tactics and specialized treatment approaches is crucial. Kaempferol, a flavonoid compound with various biological activities, has gained attention for its potential in treating neurological, cardiovascular, metabolic, and cancer-related conditions, owing to its exceptional anti-inflammatory, antioxidant, anticancer, and anti-apoptotic properties. Studies have shown that kaempferol is highly effective in protecting the kidneys and can effectively address a range of kidney diseases, including diabetic nephropathy, renal fibrosis, urinary stones, and renal cell carcinoma. Furthermore, it has been demonstrated to markedly enhance renal damage resulting from sepsis, pharmaceutical agents, and heavy metals. This review comprehensively reviews the available evidence on the therapeutic role of kaempferol in various common kidney diseases and elucidates the specific molecular mechanisms of kaempferol's nephroprotective effects. In addition, it provides insights and references for further scientific research, clinical drug development, and nutritional supplementation of kaempferol in kidney diseases.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70211"},"PeriodicalIF":4.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic Insights Into the Mitigating Effects of Grape Seed Extract on High-Fat Diet-Induced Cardiac Metabolic Alterations. 蛋白质组学研究葡萄籽提取物对高脂肪饮食诱导的心脏代谢改变的缓解作用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-16 DOI: 10.1002/mnfr.70205

Thouraya Majoul,Clément Guillou,Kamel Charradi,Pascal Cosette,Férid Limam,Ezzedine Aouani

{"title":"Proteomic Insights Into the Mitigating Effects of Grape Seed Extract on High-Fat Diet-Induced Cardiac Metabolic Alterations.","authors":"Thouraya Majoul,Clément Guillou,Kamel Charradi,Pascal Cosette,Férid Limam,Ezzedine Aouani","doi":"10.1002/mnfr.70205","DOIUrl":"https://doi.org/10.1002/mnfr.70205","url":null,"abstract":"Prevention and treatment of obesity using nutritional supplements became a realistic and effective approach. The present work aims at the assessment of the potential protection afforded by grape seed extract (GSE) on the rat cardiac proteome using a proteomic approach. Using a rodent model of obesity, we performed a comparative quantitative proteomic approach of heart samples from standard, high-fat diet (HFD) and HFD+GSE groups. LTQ OrbiTrap technology, followed by bioinformatic tools, allowed the identification of differentially abundant proteins (DAPs). GSE alleviated the HFD-induced energy metabolism alteration by recovering and/or enhancing some DAPs, such as the aconitase and the propionyl-CoA carboxylase. Also, GSE renews the capacity of cardiomyocytes to produce energy by an overabundance of complex I and complex III. Additionally, GSE improved the contractile function and alleviated cardiomyopathy in obesity following an overabundance of key contractile proteins like myosins and actinin. This study demonstrates that GSE confers cardioprotective effects in the context of obesity-induced metabolic disturbances. Through a proteomic approach, we identified key DAPs involved in energy metabolism and contractile function that were positively modulated by GSE. These findings support the potential of GSE as a promising therapeutic anti-obesity agent.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"49 1","pages":"e70205"},"PeriodicalIF":5.2,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial Transglutaminase Increases Uptake and Translocation of Gliadin Peptides in the Human Intestinal Epithelium. 微生物转谷氨酰胺酶增加人肠上皮中麦胶蛋白肽的摄取和易位。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-11 DOI: 10.1002/mnfr.70197

Sebastian Stricker,Jan De Laffolie,Klaus-Peter Zimmer,Silvia Rudloff

{"title":"Microbial Transglutaminase Increases Uptake and Translocation of Gliadin Peptides in the Human Intestinal Epithelium.","authors":"Sebastian Stricker,Jan De Laffolie,Klaus-Peter Zimmer,Silvia Rudloff","doi":"10.1002/mnfr.70197","DOIUrl":"https://doi.org/10.1002/mnfr.70197","url":null,"abstract":"Transglutaminase 2 (TG2) plays an essential role in the pathogenesis of celiac disease (CD) by modifying gliadin peptides. Additionally, microbial transglutaminase (mTG) was implicated in CD pathogenesis since it modifies gliadin peptides in the same way. mTG is used as a technical aid in the production of food items and might also be released by the intestinal microbiota. We aimed to characterize the interaction of mTG with different gliadin peptides and its effect on the epithelial and mucosal transport.We compared mTG- and TG2-mediated crosslinking of gliadin peptides using indirect enzyme-linked immunosorbent assay (ELISA) and immunoblot. Epithelial uptake of gliadin peptides P56-88 and P31-49 by Caco-2 cells and human duodenal biopsies was quantified by fluorometry and immunofluorescence microscopy. mTG had a much higher affinity towards different gliadin peptides than TG2. mTG significantly increased the uptake of gliadin peptide P56-88 and P31-49 by Caco-2 cells by nearly 10 times. Finally, mTG increased the uptake and colocalized with gliadin peptide P56-88 in the human duodenal mucosa. DmTG-mediated enzymatic modification of gliadin peptides is evident and influences the epithelial uptake of potentially detrimental gliadin peptides. The uncritical use of mTG in food production might therefore pose a potential threat for consumers.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"172 1","pages":"e70197"},"PeriodicalIF":5.2,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Polyphenols in the Prevention and Treatment of Age-Related Macular Degeneration. 多酚在防治老年性黄斑变性中的作用。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-10 DOI: 10.1002/mnfr.70199

Lidianys María Lewis-Luján,Cinthya Jhovanna Perez-Martinez,Annette Pulcherie Iloki-Lewis,Diego Emmanuel Guerrero-Magaña,Judas Vargas-Durazo,Juan Carlos Galvez-Ruiz,Grecia Fernanda Barnet,Sergio Trujillo-López,Mikhail Alexey Oshadshuk,Maxim Trushin,Simon Bernard Iloki-Assanga

引用次数: 0

Exploring the Phytochemical and Physical Stability of Phycocyanin, Anthocyanins, and Betacyanin in a Cheesecake Product. 芝士蛋糕产品中藻蓝蛋白、花青素和β蓝蛋白的植物化学和物理稳定性研究。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-08-10 DOI: 10.1002/mnfr.70191

Cristina Selin,Anda Tanislav,Laura Stan,Bernadette-Emőke Teleky,Călina Ciont Nagy,Florica Ranga,Vlad Mureşan,Andruţa Mureşan,Dan Cristian Vodnar,Mihaela Mihai,Ionela Daniela Morariu,Oana Lelia Pop

{"title":"Exploring the Phytochemical and Physical Stability of Phycocyanin, Anthocyanins, and Betacyanin in a Cheesecake Product.","authors":"Cristina Selin,Anda Tanislav,Laura Stan,Bernadette-Emőke Teleky,Călina Ciont Nagy,Florica Ranga,Vlad Mureşan,Andruţa Mureşan,Dan Cristian Vodnar,Mihaela Mihai,Ionela Daniela Morariu,Oana Lelia Pop","doi":"10.1002/mnfr.70191","DOIUrl":"https://doi.org/10.1002/mnfr.70191","url":null,"abstract":"Color has been recognized as a paramount sensory attribute in the food industry. Although synthetic colorants have traditionally been used to ensure consistent color in food products, growing concerns about their possible toxicity and environmental impact have led to a shift toward using natural, biobased pigments. This study explored the phytochemical stability of three natural colorants (phycocyanin, anthocyanins, and betacyanin) incorporated in a cheesecake product and their interactions with various sweeteners (sucrose, fructose, sorbitol, dextrose, and xylitol). The fillings and cakes were analyzed for their phytochemical composition, color, and antioxidant properties. Phycocyanin and cyanidin-3-glucoside confirmed robust stability across all sweeteners. In contrast, xylitol-sweetened cheesecake retained the highest betacyanin concentration (7.81 mg/g) and maintained it over the 5-day shelf life (p > 0.05), compared to dextrose-sweetened samples (7.07 mg/g). Dextrose and fructose significantly enhanced the stability and antioxidant properties compared to xylitol and sorbitol. These findings suggest that the choice of sweetener plays a crucial role in maintaining the stability and enhancing the health benefits of cheesecake fillings, paving the way for the development of functional foods with natural colorants.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"211 1","pages":"e70191"},"PeriodicalIF":5.2,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0