Molecular Nutrition & Food Research最新文献

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The Effect of Green Tea Extract on Pulmonary Inflammation in Nanoparticles-Exposed Mice 绿茶提取物对纳米颗粒暴露小鼠肺部炎症的影响
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-09-10 DOI: 10.1002/mnfr.202300792
Pureun-Haneul Lee, MinHyeok An, DaYeon Hwang, An-Soo Jang
{"title":"The Effect of Green Tea Extract on Pulmonary Inflammation in Nanoparticles-Exposed Mice","authors":"Pureun-Haneul Lee,&nbsp;MinHyeok An,&nbsp;DaYeon Hwang,&nbsp;An-Soo Jang","doi":"10.1002/mnfr.202300792","DOIUrl":"10.1002/mnfr.202300792","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Scope</h3>\u0000 \u0000 <p>Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are air pollutants that exacerbate chronic respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD) However, little is known about the mechanism underlying the antipollutant effects of green tea extract (GTE). This study evaluates the efficacy and mechanism of GTE on lung inflammation and fibrosis in mice exposed to TiO<sub>2</sub> NPs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>The TiO<sub>2</sub> NPs model is induced by having mice inhale TiO<sub>2</sub> NPs, while controls receive an equivalent volume of saline. Treatment with oral GTE is initiated after TiO<sub>2</sub> NPs inhalation and is given once daily for 4 weeks. Airway resistance and pulmonary inflammation are increased in mice exposed to TiO<sub>2</sub> NPs. GTE treatment reduces the airway inflammation and airway resistance, and attenuates the pathological changes including lung fibrosis compared to the mice exposed to TiO<sub>2</sub> NPs. With GTE, there are no significant increases in cytokines and immunoglobulin E (IgE) in mice exposed to TiO<sub>2</sub> NPs. GTE inhibits matrix metalloproteinases (MMPs) and apoptotic factors induced by TiO<sub>2</sub> NPs exposure, and these protective effects of GTE are closely related to the mitogen-activated protein kinase (MAPK) signaling pathway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GTE modulates pulmonary inflammation in mice exposed to air pollutants, suggesting that GTE may be beneficial in respiratory diseases exacerbated by such pollutants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142161119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventive Effect of Royal Jelly and 10-HDA on Skin Damage in Diabetic Mice through Regulating Keratinocyte Wnt/β-Catenin and Pyroptosis Pathway 蜂王浆和 10-HDA 通过调节角质细胞 Wnt/β-Catenin 和 Pyroptosis 通路对糖尿病小鼠皮肤损伤的预防作用
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-09-09 DOI: 10.1002/mnfr.202400098
Xinqi Huang, Lu Xiu, Yumei An, Yuan Gong, Sunao Li, Xueshi Chen, Chao Liu, Jianghuiwen Lu, Haiyan Shan, Jie Chang, Mingyang Zhang
{"title":"Preventive Effect of Royal Jelly and 10-HDA on Skin Damage in Diabetic Mice through Regulating Keratinocyte Wnt/β-Catenin and Pyroptosis Pathway","authors":"Xinqi Huang,&nbsp;Lu Xiu,&nbsp;Yumei An,&nbsp;Yuan Gong,&nbsp;Sunao Li,&nbsp;Xueshi Chen,&nbsp;Chao Liu,&nbsp;Jianghuiwen Lu,&nbsp;Haiyan Shan,&nbsp;Jie Chang,&nbsp;Mingyang Zhang","doi":"10.1002/mnfr.202400098","DOIUrl":"10.1002/mnfr.202400098","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <p>The objective of this study is to elucidate how Royal jelly (RJ) and 10-hydroxy-2-decanoic acid (10-HDA) prevents diabetic skin dysfunction by modulating the pyroptosis pathway. Type 2 diabetes models are induced by fat diet consumption and low dose of streptozotocin (STZ) in C57BL/6J mice and treated with RJ (100 mg kg<sup>–1</sup> day<sup>–1</sup>) and 10-HDA, the major lipid component of royal jelly (100 mg kg<sup>−1</sup> day<sup>−1</sup>) for 28 weeks. The results show that serum concentrations of glucose and triglyceride are significantly lower in the RJ group or 10-HDA than diabetes mellitus (DM) group. Compared to the control group, pyroptosis proteins, GSDMD, ASC, Caspase-1, and IL-1β are increased in the skin of the diabetic model, accompanied by the activation of the Wnt/β-catenin signal pathway. Further evaluations by RJ exhibit superior improvement of skin damage, repress activation of the Wnt/β-catenin pathway, and attenuate keratinocyte pyroptosis, but 10-HDA cannot completely suppress the activation of Wnt/β-catenin pathway and pyroptosis, which shows a relatively weak protective effect on skin damage which shows that RJ is a better effect on skin injury after DM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice 母体妊娠糖尿病和高脂饮食对 C57BL/6J 小鼠后代肝脏多不饱和脂肪酸谱的影响
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-09-09 DOI: 10.1002/mnfr.202400386
JiaYu Gong, WenHui Xu, YiFei Chen, ShuTong Chen, YanYan Wu, YiRu Chen, YueTing Li, Yuan He, HaiTao Yu, Lin Xie
{"title":"Maternal Gestational Diabetes Mellitus and High-Fat Diet Influenced Hepatic Polyunsaturated Fatty Acids Profile in the Offspring of C57BL/6J Mice","authors":"JiaYu Gong,&nbsp;WenHui Xu,&nbsp;YiFei Chen,&nbsp;ShuTong Chen,&nbsp;YanYan Wu,&nbsp;YiRu Chen,&nbsp;YueTing Li,&nbsp;Yuan He,&nbsp;HaiTao Yu,&nbsp;Lin Xie","doi":"10.1002/mnfr.202400386","DOIUrl":"10.1002/mnfr.202400386","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Scope</h3>\u0000 \u0000 <p>This research examines the effects of maternal high-fat (HF) diet and gestational diabetes mellitus (GDM) on offspring lipid metabolism and polyunsaturated fatty acids (PUFA) profile.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>GDM is induced using the insulin receptor antagonist S961. Weaning offspring are categorized into HF-GDM, HF-CON, NC-GDM, and NC-CON groups based on maternal diet or GDM. Adult offspring are then grouped into NC-CON-NC, NC-CON-HF, NC-GDM-NC, NC-GDM-HF, HF-CON-NC, HF-CON-HF, HF-GDM-NC, and HF-GDM-HF according to dietary patterns. Gas chromatography determines PUFA composition. Western blot assesses PI3K/Akt signaling pathway-related protein expression.</p>\u0000 \u0000 <p>Feeding a normal chow diet until adulthood improves the distribution of hepatic PUFA during weaning across the four groups. PI3K expression is upregulated during weaning in HF-CON and HF-GDM, particularly in HF-CON-NC and HF-GDM-NC, compared to NC-CON-NC during adulthood. Akt expression increases in NC-GDM-NC after weaning with a normal diet. The hepatic PUFA profile in HF-CON-HF significantly distinguishes among the maternal generation health groups. Maternal HF diet exacerbates the combined impact of maternal GDM and offspring HF diet on hepatic PUFA and PI3K/Akt signaling pathway-related proteins during adulthood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Early exposure to HF diets and GDM affects hepatic PUFA profiles and PI3K/Akt signaling pathway protein expression in male offspring during weaning and adulthood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EAT-Lancet Diet Pattern, Genetic Predisposition, Inflammatory Biomarkers, and Risk of Lung Cancer Incidence and Mortality EAT-Lancet 饮食模式、遗传倾向、炎症生物标志物与肺癌发病和死亡风险。
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-09-05 DOI: 10.1002/mnfr.202400448
Fubin Liu, Changyu Si, Linlin Chen, Yu Peng, Peng Wang, Xixuan Wang, Jianxiao Gong, Huijun Zhou, Jiale Gu, Ailing Qin, Ming Zhang, Liangkai Chen, Fangfang Song
{"title":"EAT-Lancet Diet Pattern, Genetic Predisposition, Inflammatory Biomarkers, and Risk of Lung Cancer Incidence and Mortality","authors":"Fubin Liu,&nbsp;Changyu Si,&nbsp;Linlin Chen,&nbsp;Yu Peng,&nbsp;Peng Wang,&nbsp;Xixuan Wang,&nbsp;Jianxiao Gong,&nbsp;Huijun Zhou,&nbsp;Jiale Gu,&nbsp;Ailing Qin,&nbsp;Ming Zhang,&nbsp;Liangkai Chen,&nbsp;Fangfang Song","doi":"10.1002/mnfr.202400448","DOIUrl":"10.1002/mnfr.202400448","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Scope</h3>\u0000 \u0000 <p>The association between a planetary and sustainable EAT-Lancet diet and lung cancer remains inconclusive, with limited exploration of the role of genetic susceptibility and inflammation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>The study includes 175 214 cancer-free participants in the UK Biobank. Fourteen food components are collected from a 24-h dietary recall questionnaire. A polygenic risk score is constructed through capturing the overall risk variants for lung cancer. Sixteen inflammatory biomarkers are assayed in blood samples. Participants with the highest EAT-Lancet diet scores (≥12) have a lower risk of lung cancer incidence (hazard ratio [HR] = 0.64, 95% confidence interval [CI]: 0.51–0.80) and mortality (HR = 0.65, 95% CI: 0.48–0.88), compared to those with the lowest EAT-Lancet diet scores (≤8). Interestingly, there is a significantly protective trend against both lung adenocarcinoma and lung squamous cell carcinoma with higher EAT-Lancet diet scores. Despite no significant interactions, a risk reduction trend for lung cancer is observed with increasing EAT-Lancet diet scores and decreasing genetic risk. Ten inflammatory biomarkers partially mediate the association between the EAT-Lancet diet and lung cancer risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study depicts a lower risk of lung cancer conferred by the EAT-Lancet diet associated with lower inflammation levels among individuals with diverse genetic predispositions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Amino Acids in the Regulation of Bone and Its Diseases 调节骨骼及其疾病的功能性氨基酸。
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-09-05 DOI: 10.1002/mnfr.202400094
Siying Li, Qinglu Tian, Liwei Zheng, Yachuan Zhou
{"title":"Functional Amino Acids in the Regulation of Bone and Its Diseases","authors":"Siying Li,&nbsp;Qinglu Tian,&nbsp;Liwei Zheng,&nbsp;Yachuan Zhou","doi":"10.1002/mnfr.202400094","DOIUrl":"10.1002/mnfr.202400094","url":null,"abstract":"<p>Bone as a vigorous tissue is constantly undergoing bone remodeling. The homeostasis of bone remodeling requires combined efforts of multifarious bone cells. Amino acids (AA), known as essential components of life support, are closely related to the regulation of bone homeostasis. In recent years, the concept of functional amino acids (FAAs) has been proposed, which is defined as AA that regulate key metabolic pathways to improve health, survival, growth, development, lactation, and reproduction of organisms, to highlight their outstanding contributions in the body. In the hope of exploring new therapeutic strategies, this review focus on summarizing recent progress in the vital role of FAAs in bone homeostasis maintaining and potential implications of FAAs in bone-related diseases, and discussing related mechanisms. The results showed that FAAs are closely related to bone metabolism and therapeutic strategy targeting FAAs metabolism is one of the future trends for bone disorders, while the explorations about possible impact of FAAs-based diets are still limited.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142131384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice 高脂饮食和富含亚麻籽油饮食对肥胖小鼠肺实质的影响
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-08-29 DOI: 10.1002/mnfr.202300050
Camila de Oliveira Ramos, Marcella Ramos Sant'Ana, Giovana Rios Gonçalves, Thaiane da Silva Rios, Susana Castelo Branco Ramos Nakandakari, Beatriz Burger, Luís Gustavo Romani Fernandes, Ricardo de Lima Zollner, Arthur Noin de Oliveira, Rodrigo Catharino Ramos, Adelino Sanchez Ramos da Silva, José Rodrigo Pauli, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Eli Mansour, Dennys Esper Cintra
{"title":"The Effects of High-Fat Diet and Flaxseed Oil-Enriched Diet on the Lung Parenchyma of Obese Mice","authors":"Camila de Oliveira Ramos,&nbsp;Marcella Ramos Sant'Ana,&nbsp;Giovana Rios Gonçalves,&nbsp;Thaiane da Silva Rios,&nbsp;Susana Castelo Branco Ramos Nakandakari,&nbsp;Beatriz Burger,&nbsp;Luís Gustavo Romani Fernandes,&nbsp;Ricardo de Lima Zollner,&nbsp;Arthur Noin de Oliveira,&nbsp;Rodrigo Catharino Ramos,&nbsp;Adelino Sanchez Ramos da Silva,&nbsp;José Rodrigo Pauli,&nbsp;Leandro Pereira de Moura,&nbsp;Eduardo Rochete Ropelle,&nbsp;Eli Mansour,&nbsp;Dennys Esper Cintra","doi":"10.1002/mnfr.202300050","DOIUrl":"10.1002/mnfr.202300050","url":null,"abstract":"<p>Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 – ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1β and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142101516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats 大蒜提取物通过α-β细胞转分化促进糖尿病大鼠的胰岛新生,并使葡萄糖稳态正常化
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-08-29 DOI: 10.1002/mnfr.202400362
Amani M. Al-Adsani, Khaled K. Al-Qattan, Sahar A. Barhoush, Manal S. Abbood, Suzanne A. Al-Bustan
{"title":"Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats","authors":"Amani M. Al-Adsani,&nbsp;Khaled K. Al-Qattan,&nbsp;Sahar A. Barhoush,&nbsp;Manal S. Abbood,&nbsp;Suzanne A. Al-Bustan","doi":"10.1002/mnfr.202400362","DOIUrl":"10.1002/mnfr.202400362","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Scope</h3>\u0000 \u0000 <p>Garlic extract (GE) has been shown to ameliorate hyperglycemia in diabetic rats (DRs) by increasing insulin production. However, the mechanism through which it exerts its effects remains unclear. Here, it investigates the molecular process and the origin of regenerating β-cell in rats with streptozotocin (STZ)-induced diabetes in response to GE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>In this study, quantitative RT-PCR (qRT-PCR), western blotting, and immunohistochemical analysis are carried out after pancreas isolation. These findings show that 1 week of GE treatment increases the expression of the endocrine progenitor cell markers Neurogenin3 (<i>Neurog3</i>), pancreatic and duodenal homeobox 1 (<i>Pdx1</i>), neurogenic differentiation factor 1 (<i>Neurod1)</i>, paired box proteins (<i>Pax</i>)<i>4</i>, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B (<i>Mafb)</i>, and NK homeobox factors (<i>Nkx</i>)<i>6-1</i> in STZ-induced DRs. Continuation with GE treatment for 8 weeks causes the expression of the mature β-cell markers insulin<i>(Ins)2</i>, urocortin3 (<i>Ucn3</i>), and glucose transporter 2 (<i>Glut2)</i> to peak. Comprehensive examination of the islet through immunohistochemical analysis reveals the presence of a heterogeneous cell population including INS+/GLUT2− and INS+/GLUT2+ β-cell subpopulations with few bihormonal INS+/GCG+ cells after 4 weeks. By week 8, islet architecture is reestablished, and glucose-stimulated insulin secretion was restored through the upregulation of <i>Ucn3</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GE induces β-cell neogenesis in DRs and restores islet architecture. The newly formed mature β-like cells could have originated through the differentiation of endocrine progenitor cells as well as α- to β-cell transdifferentiation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 19","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142101517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats 青春期前大鼠对葡萄籽原花青素的吸收、分配、代谢和排泄的性别差异
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-08-28 DOI: 10.1002/mnfr.202400399
Lisard Iglesias-Carres, Anna Mas-Capdevila, Francisca I. Bravo, Manuel Suárez, Anna Arola-Arnal, Begoña Muguerza
{"title":"Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats","authors":"Lisard Iglesias-Carres,&nbsp;Anna Mas-Capdevila,&nbsp;Francisca I. Bravo,&nbsp;Manuel Suárez,&nbsp;Anna Arola-Arnal,&nbsp;Begoña Muguerza","doi":"10.1002/mnfr.202400399","DOIUrl":"10.1002/mnfr.202400399","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Scope</h3>\u0000 \u0000 <p>The absorption, disposition, metabolism, and excretion (ADME) of phenolic compounds are key factors in determining their bioactivity. The group demonstrates that the ADME of a Grape Seed Proanthocyanidin Extract (GSPE) depends on sex in adult rats and specifically, methylated metabolites are only quantified in brain male adult rats. The aim of this study is to determine whether these differences exist before puberty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and results</h3>\u0000 \u0000 <p>Prepubescent 4-week-old male and female Wistar rats are administered GSPE at a dose of 1000 mg kg<sup>−1</sup>. Plasma, liver, mesenteric white adipose tissue (MWAT), brain, and kidneys are extracted excised 2 h after GSPE administration, and the PAs metabolite profile is studied by HPLC-ESI-MS/MS. Moreover, plasma estradiol and brain and liver catechol-<i>O</i>-methyltransferase (COMT) protein levels are also studied. Results showed that there are no differences in plasma and brain among sexes and only differences are observed in liver, MWAT, and kidney with individual metabolites. This agrees with the lack of differences in estradiol and COMT levels among sexes. However, the ADME of PAs metabolites is higher in male rats.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results demonstrate lack of sex-dependence in metabolite profile in prepubescent rats, suggesting that sex differences in the metabolism of GSPE occur due to puberty.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 18","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.202400399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142078664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Lactococcus lactis KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by Nε-Carboxymethyl-Lysine and High-Fat Diet 封面:乳酸乳球菌 KF140 可改善 Nε-Carboxymethyl-Lysine 和高脂饮食诱发的非酒精性脂肪性肝病
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-08-28 DOI: 10.1002/mnfr.202470027
Hye-Bin Lee, Miri Park, So-Young Lee, Sang Keun Ha, Yoonsook Kim, Kwang-Won Lee, Ho-Young Park
{"title":"Front Cover: Lactococcus lactis KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by Nε-Carboxymethyl-Lysine and High-Fat Diet","authors":"Hye-Bin Lee,&nbsp;Miri Park,&nbsp;So-Young Lee,&nbsp;Sang Keun Ha,&nbsp;Yoonsook Kim,&nbsp;Kwang-Won Lee,&nbsp;Ho-Young Park","doi":"10.1002/mnfr.202470027","DOIUrl":"10.1002/mnfr.202470027","url":null,"abstract":"<p><i>Mol. Nutr. Food Res</i>. 2024, <i>68</i>, 2400260</p><p>DOI: 10.1002/mnfr.202400260</p><p>The cover image is based on the Article <i>Lactococcus lactis KF140 Ameliorates Nonalcoholic Fatty Liver Disease Induced by N<sup>ε</sup>-Carboxymethyl-Lysine and High-Fat Diet</i> by Hye-Bin Lee et al., https://doi.org/10.1002/mnfr.202400260\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 16","pages":""},"PeriodicalIF":4.5,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.202470027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: Mol. Nutr. Food Res. 16'24 发行信息:Mol.Nutr.16'24
IF 4.5 2区 农林科学
Molecular Nutrition & Food Research Pub Date : 2024-08-28 DOI: 10.1002/mnfr.202470028
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