Molecular Nutrition & Food Research最新文献_第8页

Trimethylamine N-Oxide Plasma Levels Following Red Meat and Cod Fish Intake: A Pilot Crossover Trial in Hemodialysis Patients 摄入红肉和鳕鱼后三甲胺n -氧化物血浆水平：血液透析患者的先导交叉试验

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-13 DOI: 10.1002/mnfr.70031

Larissa de Mattos Manhães, Ludmilla Santana, Marcelo Ribeiro Alves, Priscila Mansur Leal, Patricia Coelho de Velasco, Isabelle Santana, Jessyca Sousa de Brito, Denise Mafra, Natália Alvarenga Borges

{"title":"Trimethylamine N-Oxide Plasma Levels Following Red Meat and Cod Fish Intake: A Pilot Crossover Trial in Hemodialysis Patients","authors":"Larissa de Mattos Manhães, Ludmilla Santana, Marcelo Ribeiro Alves, Priscila Mansur Leal, Patricia Coelho de Velasco, Isabelle Santana, Jessyca Sousa de Brito, Denise Mafra, Natália Alvarenga Borges","doi":"10.1002/mnfr.70031","DOIUrl":"10.1002/mnfr.70031","url":null,"abstract":"<div>\u0000 \u0000 <p>Scope: The uremic toxin trimethylamine <i>N</i>-oxide (TMAO) accumulates in patients with chronic kidney disease (CKD) and is associated with its progression, cardiovascular disease, and other complications. The gut microbiota produces TMAO from substrates mainly found in red meat, eggs, and dairy. However, some saltwater fish also contain high levels of TMAO. Although fish consumption is generally linked to beneficial effects, its effects on CKD patients require further research. Methods and results: This study compares the effect of red meat and cod fish intake on TMAO plasma levels in CKD patients undergoing hemodialysis (HD). Participants received a single animal protein source (red meat vs. cod fish) for lunch and dinner for four consecutive days (each intervention), with a 2-week washout period in between. TMAO plasma levels were analyzed using LC-MS/MS. All 14 patients concluded the red meat intervention, while one refused to participate in the fish intervention. No significant difference in TMAO plasma levels was found post-red meat (<i>p</i> = 0.21) or fish intervention (<i>p</i> = 0.91), as well as between groups (<i>p</i> = 0.43). Conclusion: In this study, 4 days of red meat and cod fish intake did not significantly impact TMAO levels in HD patients, while other factors may be associated with their circulating levels.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143608711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells s -甲基- l-半胱氨酸亚砜的主要代谢物s -甲基甲乙硫磺酸改变前列腺癌细胞的能量代谢

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-09 DOI: 10.1002/mnfr.70008

Gemma Beasy, Federico Bernuzzi, Priscilla Day-Walsh, Perla Tronsco-Rey, Marianne Defernez, Shikha Saha, Richard F. Mithen, Maria H. Traka, Paul A. Kroon

{"title":"S-Methyl Methanethiosulfonate, the Main Human Metabolite of S-Methyl-L-Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells","authors":"Gemma Beasy, Federico Bernuzzi, Priscilla Day-Walsh, Perla Tronsco-Rey, Marianne Defernez, Shikha Saha, Richard F. Mithen, Maria H. Traka, Paul A. Kroon","doi":"10.1002/mnfr.70008","DOIUrl":"10.1002/mnfr.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Cruciferous and allium vegetables contain the sulfur compound S-methyl-L-cysteine-sulfoxide (SMCSO). Considering SMCSO is found at a higher abundance compared to the glucosinolates, there are limited reports on its effect on health, with the majority of the evidence on the beneficial effects on glucose metabolism in rodent models. In the current study, we investigated the metabolic effects of SMCSO and its metabolite, S-methyl methanethiosulfonate (MMTSO), on prostate cancer metabolism. DU145 prostate cancer cells were cultured in 5.5 mM (basal), 10 mM (intermediate) and 25 mM (high) glucose concentrations in the presence of SMCSO or MMTSO (100 µM). Using Seahorse technology, MMTSO but not SMCSO reduced mitochondrial metabolism, mitochondrial ATP, and the percentage of oxidative phosphorylation and increased the fatty acid dependency of DU145 cells. Transcriptomic and metabolomic analyses observed cellular and energy metabolism pathways and immune response changes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <p>These data show that MMTSO alters several features of energy metabolism in DU145 prostate cancer cells, shifting them towards a non-cancerous phenotype. These data are consistent with the notion that MMTSO may contribute to the beneficial effects of a broccoli-rich diet and metabolic effects of prostate cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Osteoporosis and Bone Protective Effects of Resveratrol in Rats With Chronic Kidney Disease-Induced Osteoporosis 白藜芦醇对慢性肾病性骨质疏松大鼠的抗骨质疏松及骨保护作用

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-05 DOI: 10.1002/mnfr.70017

Enzhe Zhao, Jian Zhu, Haihu Hao, Rui Zhang, Dou Wu

{"title":"Anti-Osteoporosis and Bone Protective Effects of Resveratrol in Rats With Chronic Kidney Disease-Induced Osteoporosis","authors":"Enzhe Zhao, Jian Zhu, Haihu Hao, Rui Zhang, Dou Wu","doi":"10.1002/mnfr.70017","DOIUrl":"10.1002/mnfr.70017","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic kidney disease (CKD)–induced osteoporosis is a new concept that implies CKD-related impaired bone quality. Resveratrol (RES) is a natural component, known for its anti-inflammatory and anti-osteoporotic effects. In the present study, we aimed to investigate the bone-protective and anti-osteoporotic effects of resveratrol in rats with chronic kidney disease-induced osteoporosis. The 5/6th nephrectomy (Nx) model of CKD was established. Resveratrol and alendronate (ALN), as standard drug, were administered for 45 days. Blood samples and femurs were collected and subjected to molecular analysis, micro-CT, and bone mechanical tests. The results showed a significant decrease in Ca levels but no significant changes in 1,25 vitamin D and phosphorus levels in untreated and treated CKD groups. Treatment with RES and ALN did not reverse the increase of serum parathyroid hormone while reducing the elevated FGF-23 levels. Unlike ALN, RES had no significant effect on increased alkaline phosphatas levels or decreased osteocalcin and OPG levels in CKD rats. Moreover, results showed that RES reversed the increase of RANKL and TRAP in serum and femur tissue close to the control level, leading to an improvement in bone strength and microarchitecture. In conclusion, the present study showed beneficial anti-osteoporotic effects of RES on CKD-induced osteoporosis.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postbiotics Made From Selected Lactic Acid Bacteria Improves Chronic Restraint Stress-Induced Anhedonia and Sleep Disorders 由选定乳酸菌制成的后生制剂改善慢性约束应激性快感缺乏和睡眠障碍

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-05 DOI: 10.1002/mnfr.70005

Jinxing Li, Yimei Wang, Simou Wu, Zhimo Zhou, Wen Jia, Xi Shen, Yun Li, Fang He, Ruyue Cheng

{"title":"Postbiotics Made From Selected Lactic Acid Bacteria Improves Chronic Restraint Stress-Induced Anhedonia and Sleep Disorders","authors":"Jinxing Li, Yimei Wang, Simou Wu, Zhimo Zhou, Wen Jia, Xi Shen, Yun Li, Fang He, Ruyue Cheng","doi":"10.1002/mnfr.70005","DOIUrl":"10.1002/mnfr.70005","url":null,"abstract":"<div>\u0000 \u0000 <p>Sleep disorders have become one of the most prevalent neuropsychiatric disorders in recent years. This study aimed to investigate the effects of postbiotics derived from selected lactic acid bacteria on anhedonia and sleep disorders in chronic restraint stress (CRS)-induced mice, as well as their potential mechanisms. Mice were orally administered normal saline, low, medium, or high doses of postbiotics for 30 days, with CRS applied from days 1 to 21. The medium dose of postbiotics significantly increased the sucrose preference index, and the high dose of postbiotics significantly increased sleep duration. Postbiotic treatment effectively restored the diversity and composition of the gut microbiota to levels comparable to those observed in the vehicle (Veh) group. Furthermore, low and medium doses of postbiotics significantly reduced serum corticosterone levels, and medium and high doses significantly reduced serum IL-1β levels. Additionally, postbiotics administration significantly increased glutamate and GABA levels in both the prefrontal cortex and hypothalamus, as well as GABA levels in the feces. These results indicate that postbiotics alleviate CRS-induced anhedonia and sleep disorders in a dose-dependent manner. This effect may be mediated through the restoration of homeostasis in the MGB axis, HPA axis, inflammation pathways, and neurotransmitter balance.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 5'25 发布信息：Mol. Nutr。Food Res. 5分25秒

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-03 DOI: 10.1002/mnfr.70020

引用次数: 0

Impact of High-Pressure Processing on Phenolic Compound Accumulation and Expression of Key Biosynthetic Genes in Harvested Strawberries 高压处理对收获草莓酚类化合物积累及关键生物合成基因表达的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-03 DOI: 10.1002/mnfr.202400882

Tae Eun Kim, Jaeho Pyee

引用次数: 0

Effects of Skim Milk Whey-Derived Proteins on Plasma, Urine, and Gut Metabolites in Preterm Piglets as a Model for Infants 脱脂奶乳清衍生蛋白对作为婴儿模型的早产仔猪血浆、尿液和肠道代谢物的影响

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-02-28 DOI: 10.1002/mnfr.70007

Yongxin Ye, Pingping Jiang, Karoline Aasmul-Olsen, Halise Gül Akıllıoğlu, Ann Bjørnshave, Mie Rostved Bechshøft, Marianne Nissen Lund, Per Torp Sangild, Stine Brandt Bering, Bekzod Khakimov

{"title":"Effects of Skim Milk Whey-Derived Proteins on Plasma, Urine, and Gut Metabolites in Preterm Piglets as a Model for Infants","authors":"Yongxin Ye, Pingping Jiang, Karoline Aasmul-Olsen, Halise Gül Akıllıoğlu, Ann Bjørnshave, Mie Rostved Bechshøft, Marianne Nissen Lund, Per Torp Sangild, Stine Brandt Bering, Bekzod Khakimov","doi":"10.1002/mnfr.70007","DOIUrl":"10.1002/mnfr.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>This study investigates the metabolic impact of skim milk whey-derived protein concentrate (SPC) for infant formula, including its heat-treated (HT-SPC) and stored (HTS-SPC) variants, on the plasma, urine, and gut metabolites of newborn piglets, compared to conventional whey protein concentrate (WPC). Preterm piglets were fed formula containing WPC, SPC, HT-SPC, or HT-SPC, HTS-SPC for 5 days. Metabolomic analysis of plasma, urine, and colon content was performed using 1H NMR. Relative to WPC, SPC mainly affected colon content metabolites, increasing 19 metabolites in the colon and tyrosine in plasma, while decreasing pyruvate in colon content and glycine in plasma. Heat-treatment and storage of SPC led to increased metabolite concentrations in colon contents and urine. Notably, significant correlations between gut metabolites and abundant gut bacteria genes were observed only in the SPC-fed pigs. SPC induced higher branched chain amino acid concentrations in the gut, but had minimal effects on plasma and urinary metabolites, likely due to differences in dietary proteins and in microbiota metabolism. While the clinical effects of SPC-induced gut branched chain amino acids remain unclear, the results from our study suggest that SPC-based infant formula is metabolically safe for sensitive newborns, comparable to WPC-based formulas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon 粪便挥发性有机化合物的独特特征区分溃疡性结肠炎患者的回肠袋和那些完整的结肠

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-02-28 DOI: 10.1002/mnfr.70003

Chu K. Yao, Kraig Green, Alice S. Day, Zaid M. Ardalan, Rachael Slater, Robert V. Bryant, Peter R. Gibson, Chris Probert

{"title":"Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon","authors":"Chu K. Yao, Kraig Green, Alice S. Day, Zaid M. Ardalan, Rachael Slater, Robert V. Bryant, Peter R. Gibson, Chris Probert","doi":"10.1002/mnfr.70003","DOIUrl":"10.1002/mnfr.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Fecal volatile organic compounds (VOCs) offer insights into gut microbiota function that may drive the pathogenesis of ulcerative colitis (UC). This cross-sectional study aimed to compare dietary intake and VOC patterns in UC patients with an ileoanal pouch compared to those with an intact colon. Seven-day food records and fecal samples were collected from UC patients with an intact colon (<i>n</i> = 28) or an ileoanal pouch (<i>n</i> = 11). Fecal VOC profiles were analyzed using gas chromatography-mass spectrometry. Dietary intake in both groups was largely similar. The mean Jaccard similarity index of VOC was 0.55 (95% CI:0.53, 0.56) in the pouch compared with 0.48 (0.47, 0.49) in the colon group (<i>p</i> < 0.01). A lower proportion of VOC classes was detected in the pouch, including sulfide (9% vs. 57%; <i>p</i> < 0.01), branched-chain fatty acids (BCFAs; 45%–64% vs. 93%–96%; <i>p</i> < 0.01), and ketones (45%–64% vs. 93%–96%; <i>p</i> < 0.01), along with a higher proportion of butyric acid (91% vs. 29%; <i>p</i> < 0.001). Unrelated to diet, VOC profiles show less functional diversity, reduced protein and greater carbohydrate fermentation, and altered production of secondary metabolites in the UC-pouch compared with the intact colon. These differences in the metabolic environment of the gut microbiota provide insights into pathogenesis and suggest that microbial-targeted interventions should be tailored accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal IncRNAs and circRNAs Regulated by Dietary-Lipid Stimuli 肠道incrna和circrna受饮食-脂质刺激调控

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-02-25 DOI: 10.1002/mnfr.70004

Luis A. Chapado, Carmen Crespo, Joao Tomé-Carneiro, Judit Gil-Zamorano, María-Carmen López de las Hazas, Ana I. Ortiz, Carmen Mazarío-Gárgoles, Daniel Sánchez-López, Veronique Touche, Henar Ortega-Senovilla, Sophie Lestavel, Olivier Briand, Bart Staels, Alberto Dávalos

{"title":"Intestinal IncRNAs and circRNAs Regulated by Dietary-Lipid Stimuli","authors":"Luis A. Chapado, Carmen Crespo, Joao Tomé-Carneiro, Judit Gil-Zamorano, María-Carmen López de las Hazas, Ana I. Ortiz, Carmen Mazarío-Gárgoles, Daniel Sánchez-López, Veronique Touche, Henar Ortega-Senovilla, Sophie Lestavel, Olivier Briand, Bart Staels, Alberto Dávalos","doi":"10.1002/mnfr.70004","DOIUrl":"10.1002/mnfr.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>A diet rich in lipids can lead to many deleterious conditions, which involve many regulatory molecules, such as non-coding (nc)RNAs. We aimed to analyze the effects of high dietary lipid exposure on the expression of intestinal ncRNAs (long non-coding [lncRNAs] and circular [circRNAs]). lncRNAs and circRNAs were screened, both in vivo (mice) and in vitro (human intestinal organoids). In vivo, 15 lncRNAs (9 up- and 6 downregulated) and 41 circRNAs (13 up- and 28 downregulated) were modulated 3 h after a lipid challenge, while the expression of 11 lncRNAs (4 up- and 7 downregulated) was altered after 4 days of daily high-fat diet intake. In vitro, 251 up- and 387 downregulated lncRNAs, along with 19 up- and 16 downregulated circRNAs, were found 3 h after the exposure to a dietary-lipid stimulus, whereas 111 up- and 86 downregulated lncRNAs were found 24 h after exposure. Concord between the differently expressed ncRNAs found in both studies was scarce. Numerous differentially expressed lncRNAs and circRNAs have been found in response to dietary lipids both in mice and humans organoids. A potential association between many of these ncRNAs and lipid metabolism is suggested, but ncRNAs found differ greatly between humans and mice.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism 不同花源蜂蜜中多酚和抗坏血酸对肝脏酒精代谢的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-02-23 DOI: 10.1002/mnfr.202400539

Zhiwei Sun, Lanhua Liu, Xingjiang Li, Jinjing Zhang, Hao Zhou, Dongdong Mu, Yousheng Wang, Xuefeng Wu

{"title":"Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism","authors":"Zhiwei Sun, Lanhua Liu, Xingjiang Li, Jinjing Zhang, Hao Zhou, Dongdong Mu, Yousheng Wang, Xuefeng Wu","doi":"10.1002/mnfr.202400539","DOIUrl":"https://doi.org/10.1002/mnfr.202400539","url":null,"abstract":"Honey is known to promote alcohol metabolism effectively. However, the effects of its individual chemical components system on alcohol metabolism and their mechanisms of action have not yet been fully elucidated. We constructed polyphenols and ascorbic acid systems (PAAS) of six different floral kinds of honey by exogenous substances, to investigate their effects on alcohol metabolism in the liver. PAAS consists of 22 kinds of polyphenols (including arbutin and caffeic acid) and ascorbic acid. The results demonstrated that PAAS improved the activity of alcohol dehydrogenase (ADH) and the expression of <i>adh1</i>, but had no significant effect on acetaldehyde dehydrogenase (ALDH) and expression of <i>adh2</i>, which caused a decrease in blood ethanol concentration but no difference in acetaldehyde concentration. Correlation analysis illustrated that arbutin and trans-4-hydroxycinnamic acid in PAAS were important potential substances for promoting alcohol metabolism. In addition, PAAS could also reduce the deleterious effects of alcohol by modulating unsaturated fatty acid biosynthesis, purine metabolism, and other metabolic pathways in the liver. These findings revealed the mechanisms by which PAAS promoted hepatic alcohol metabolism as well as protected the liver and provided a theoretical basis for exploring the mechanisms in honey synergistically promote alcohol metabolism.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"82 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0