Molecular Nutrition & Food Research最新文献_第8页

Obesity Parameters in Women Is Associated With AMY1 Gene Copy Number, Nesfatin‐1 Level, and Dietary Intake: A Case‐Control Study 女性肥胖参数与AMY1基因拷贝数、Nesfatin - 1水平和饮食摄入相关：一项病例对照研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-07 DOI: 10.1002/mnfr.70049

Fatma Tayhan, Gizem Helvacı, Nurcan Yabancı Ayhan

{"title":"Obesity Parameters in Women Is Associated With AMY1 Gene Copy Number, Nesfatin‐1 Level, and Dietary Intake: A Case‐Control Study","authors":"Fatma Tayhan, Gizem Helvacı, Nurcan Yabancı Ayhan","doi":"10.1002/mnfr.70049","DOIUrl":"https://doi.org/10.1002/mnfr.70049","url":null,"abstract":"AMY1 gene copy number (GCN) variations and the satiety hormone Nesfatin‐1 have recently emerged as potential contributors to obesity and related metabolic disturbances. This study evaluated the relationship between AMY1 GCN, Nesfatin‐1 level, and nutritional status in obese/overweight and normal‐weight women. Participants included 40 normal‐weight and 45 overweight/obese women aged 19–50. Data were collected through a demographic and dietary habits questionnaire, a 3‐day food recall, anthropometric measurements, and body composition analysis via bioelectrical impedance. Saliva samples were used to measure AMY1 GCN and Nesfatin‐1 levels. The AMY1 GCN was significantly lower in overweight/obese participants compared to normal‐weight participants. Increased AMY1 GCN was associated with a decrease in BMI (−0.154 units), while increased Nesfatin‐1 level was linked to a rise in BMI (0.196 units) (p < 0.05). Women with low AMY1 GCN had higher daily intakes of energy, carbohydrate, protein, and fat (p < 0.05). This study highlights the significant roles of AMY1 GCN and Nesfatin‐1 in the development of obesity. The findings suggest that lower AMY1 GCN and higher Nesfatin‐1 levels are associated with unfavorable nutritional and metabolic profiles. Further comprehensive studies on genetic and hormonal factors, including AMY1 GCN and Nesfatin‐1, are recommended to guide obesity prevention and treatment strategies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"59 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases 脂肪酸与白藜芦醇联合治疗眼部疾病的研究进展

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-07 DOI: 10.1002/mnfr.70037

Dominique Delmas, Maude Perus, Virginie Aires, François Hermetet

{"title":"Current Advances in the Combination of Fatty Acids and Resveratrol to Fight Ocular Diseases","authors":"Dominique Delmas, Maude Perus, Virginie Aires, François Hermetet","doi":"10.1002/mnfr.70037","DOIUrl":"https://doi.org/10.1002/mnfr.70037","url":null,"abstract":"Omega-3 polyunsaturated fatty acids (PUFA) and polyphenols have attracted interest to counteract ocular diseases and more specifically age-related macular degeneration (AMD). This eye disease, which is the leading cause of irreversible blindness in industrialized countries, is characterized by damage to the central part of the retina, the macula. Despite therapeutic advances with the use of anti-vascular endothelial growth factor (VEGF) monoclonal antibodies, numerous resistance mechanisms that worsen visual impairment have been identified. In this context, we highlight the exceptional potential of polyphenols and PUFA in addressing AMD through their actions on the different molecular mechanisms involved in AMD progression. More specifically, this review focuses on the current understanding of the effects of resveratrol, as well as docosahexaenoic and eicosapentaenoic acids, two prominent omega-3 PUFA, and the combination of these compounds. We also discuss the limitations and explore future directions for the combined use of these natural products as preventive or complementary therapies to preserve vision and slow disease progression.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"37 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment 天然多酚在乳腺癌化学防治中的作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-07 DOI: 10.1002/mnfr.70055

Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca

{"title":"Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment","authors":"Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca","doi":"10.1002/mnfr.70055","DOIUrl":"https://doi.org/10.1002/mnfr.70055","url":null,"abstract":"Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to drug resistance and metastatic progression. Owing to their low toxicity and high variety, natural products and their derivatives are becoming increasingly valuable sources for small‐molecule anticancer drugs. Polyphenols are becoming more widely known for their role in breast cancer prevention and as adjuvants in conventional treatment strategies. Therefore, this review focuses on the antitumor effects of curcumin, resveratrol, and polydatin on breast cancer. According to the main databases, only in vitro and preclinical studies with solid scientific backgrounds and reports of protective effects on breast cancer treatment were included. Curcumin, resveratrol, and polydatin have antioxidant, anti‐inflammatory, and anticancer effects; indeed, they improve drug efficacy; reduce chemoresistance, angiogenesis, and tumor growth; and induce apoptosis, autophagy, and cell cycle arrest in breast cancer through multiple molecular pathways, including the suppression of epithelial–mesenchymal transition (EMT), NF‐κB, PI3K/Akt/mTOR, c‐Jun N‐terminal kinase (JNK), MAPK, ERK1/2, and STAT signaling pathways; the inhibition of cyclins and matrix metalloproteinase (MMP)‐2 and MMP‐9; and the activation of p53 and microtubule‐associated protein light chain 3 (LC3).","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"43 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bangle (Zingiber purpureum Rosc.) Extract Ameliorates Colonic Inflammation and Upregulates Autophagy via the Modulation of the AMPK/mTOR/NFκB Pathway in a Mouse Colitis Model. 手镯（Zingiber purpureum Rosc.）在小鼠结肠炎模型中，提取物通过调节AMPK/mTOR/NFκB通路改善结肠炎症并上调自噬

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-03 DOI: 10.1002/mnfr.70034

Shiho Kasai, Anishma Karmacharya, Yuuka Mukai, Shin Sato

{"title":"Bangle (Zingiber purpureum Rosc.) Extract Ameliorates Colonic Inflammation and Upregulates Autophagy via the Modulation of the AMPK/mTOR/NFκB Pathway in a Mouse Colitis Model.","authors":"Shiho Kasai, Anishma Karmacharya, Yuuka Mukai, Shin Sato","doi":"10.1002/mnfr.70034","DOIUrl":"https://doi.org/10.1002/mnfr.70034","url":null,"abstract":"Bangle, a perennial herb belonging to the ginger family with antiinflammatory properties, has been under-researched in ulcerative colitis. This study aimed to investigate the effects of Bangle extract (BaE) on inflammation and autophagy in the colons of mice with dextran sulfate sodium (DSS)-induced colitis. Male C57BL/6J mice were assigned to four groups: control, DSS + 0% BaE, DSS + 1% BaE, and DSS + 3% BaE. The BaE groups were fed BaE diets for 3 weeks, followed by an additional week of BaE diets and 3% DSS in the water. The control group received a standard chow diet and water for 4 weeks. Plasma leucine-rich α2-glycoprotein (LRG) levels, macrophage count, and the levels of nuclear factor kappa B (NFκB) p65, tumor necrosis factor-α (TNF-α), adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), mechanistic target of rapamycin (mTOR), and autophagy markers were analyzed. In the DSS + 0% BaE group, LRG levels, macrophage count, NFκB p65 protein, and TNF-α mRNA levels were significantly higher compared to the control group. However, in the DSS + 3% BaE group, these levels were significantly reduced. Additionally, PGC-1α and phosphorylated AMPK levels were increased, while phosphorylated mTOR levels decreased, and autophagy marker microtubule-associated protein 1 light chain 3B (LC3B)-II levels were increased in the DSS + 3% BaE group. BaE may ameliorate colonic inflammation and upregulate autophagy via the modulation of the AMPK/mTOR/NFκB pathway in DSS-induced colitis.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70034"},"PeriodicalIF":4.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arctiin Inhibits Hyperglycemia-Induced Oxidative Stress by Activating the Nrf2/HO-1 Signaling Pathway to Treat Type 2 Diabetic Osteoporosis. 牛蒡子苷通过激活Nrf2/HO-1信号通路抑制高血糖诱导的氧化应激治疗2型糖尿病骨质疏松

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-03 DOI: 10.1002/mnfr.70053

Weipeng Sun, Minying Li, Qing Lin, Xueshan Jin, Biyi Zhao, Ziwei Jiang, Ronghua Zhang, Xiaoyun Li

{"title":"Arctiin Inhibits Hyperglycemia-Induced Oxidative Stress by Activating the Nrf2/HO-1 Signaling Pathway to Treat Type 2 Diabetic Osteoporosis.","authors":"Weipeng Sun, Minying Li, Qing Lin, Xueshan Jin, Biyi Zhao, Ziwei Jiang, Ronghua Zhang, Xiaoyun Li","doi":"10.1002/mnfr.70053","DOIUrl":"https://doi.org/10.1002/mnfr.70053","url":null,"abstract":"Arctiin (ARC), a primary component of burdock (Arctium lappa L.), is widely recognized as a traditional herb and nutritional supplement in Asia. This study set out to explore its potential impact on type 2 diabetic osteoporosis (T2DOP). MC3T3-E1 cells were exposed to a high-glucose environment to simulate diabetic conditions. Treatment with ARC increased the expression of crucial osteogenic transcription factor genes, such as RUNX2, Osterix, and COL1A1. Moreover, ARC mitigated the production of ROS induced by high glucose levels. For in vivo experimentation, db/db mice were used as models for T2DOP. ARC supplementation decreased bone loss and improved bone structural integrity. Collectively, our findings indicate that ARC holds promise as a nutritional intervention for the treatment of T2DOP. By activating the Nrf2/HO-1 signaling pathway, ARC could help counteract oxidative stress and impaired bone differentiation associated with diabetes, thus offering a potential dietary strategy to support bone health. Incorporating ARC-containing foods or supplements into the diet could be a beneficial approach to enhance overall bone quality and potentially reduce the risk of fractures and other bone-related problems in patients with diabetes, highlighting the importance of considering natural compounds for the nutritional management of chronic diseases.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70053"},"PeriodicalIF":4.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic Effects and Mechanisms of Polyphenols From Myrica rubra Pomace in Type 2 Diabetes (db/db) Mice 杨梅果渣多酚对2型糖尿病小鼠的降糖作用及其机制（db/db）

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-02 DOI: 10.1002/mnfr.202400523

Guoli Chang, Siyi Tian, Xinyu Luo, Yannan Xiang, Chenggang Cai, Ruiyu Zhu, Haiying Cai, Hailong Yang, Haiyan Gao

{"title":"Hypoglycemic Effects and Mechanisms of Polyphenols From Myrica rubra Pomace in Type 2 Diabetes (db/db) Mice","authors":"Guoli Chang, Siyi Tian, Xinyu Luo, Yannan Xiang, Chenggang Cai, Ruiyu Zhu, Haiying Cai, Hailong Yang, Haiyan Gao","doi":"10.1002/mnfr.202400523","DOIUrl":"https://doi.org/10.1002/mnfr.202400523","url":null,"abstract":"The Myrica rubra pomace polyphenols (MRPP) were used to study their hypoglycemic effects and mechanisms using Type 2 diabetes (T2D) (db/db) mice as the model. The results showed that the oral administration of MRPP (low-dose myricitrin, 50 mg/kg BW by gavage; high-dose myricitrin, 250 mg/kg BW by gavage; and Myrica rubra pomace, 500 mg/kg BW by gavage) for 4 weeks significantly reduced fasting blood glucose, glycated serum protein, serum insulin, and insulin resistance index in mice, as well as the dyslipidemia in mice was improved. MRPP was able to improve the structural morphology of hepatocytes and pancreatic β-cells in diabetic mice. Its hypoglycemic mechanism may involve the upregulation of GLUT-4 and IRS-1 genes expression in the PI3K and AMPK signaling pathways, downregulation of GSK-3β, AMPK, PI3K, and AKT genes expression, and enhancement of the activity of enzymes related to glycogen synthesis and glucose metabolism. Research findings on 16S rRNA suggest that MRPP has the ability to alter the composition of the gut microbiota, impede the growth of harmful bacteria, and foster the growth of beneficial bacteria. Therefore, MRPP was capable of reshaping the specific gut microbial community and supporting its application as a novel supplement in functional foods for the treatment of T2D.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"67 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Properties of Live and Thermally-Inactivated Food-Origin Lactic Acid Bacteria—In Vitro Studies 活的和热灭活的食源性乳酸菌免疫调节特性的体外研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-01 DOI: 10.1002/mnfr.70047

Wioletta Mosiej, Ewa Długosz, Marcin Kruk, Dorota Zielińska

{"title":"Immunomodulatory Properties of Live and Thermally-Inactivated Food-Origin Lactic Acid Bacteria—In Vitro Studies","authors":"Wioletta Mosiej, Ewa Długosz, Marcin Kruk, Dorota Zielińska","doi":"10.1002/mnfr.70047","DOIUrl":"https://doi.org/10.1002/mnfr.70047","url":null,"abstract":"The study investigates the strain-specific immunomodulatory properties of live and thermally-inactivated (TI) lactic acid bacteria (LAB) derived from traditional Polish fermented foods, focusing on their potential as probiotics and postbiotics. LAB strains, known for their role in food fermentation, were assessed for their ability to influence cytokine production in THP-1 macrophages, maintain intestinal epithelial barrier integrity in Caco-2 monolayers, exhibit antioxidant activity, and produce specific organic acids and sugars. The research demonstrated that live LAB strains significantly upregulated the anti-inflammatory cytokine IL-10, particularly under inflammatory conditions, while TI strains exhibited notable antioxidant and anti-inflammatory properties. TI strains showed a greater ability to protect epithelial barrier function and reduce pro-inflammatory cytokine secretion than live strains, suggesting a promising role for postbiotics. The findings underscore the potential of LAB from fermented foods, demonstrating that postbiotic derivatives can differently influence inflammation compared to live bacteria, highlighting their potential as immune-enhancing agents, capable of modulating immune responses and offering therapeutic benefits against inflammation-related disorders. However, the limitations of in vitro models highlight the need for further in vivo and clinical studies to validate these effects and fully uncover the health benefits of these LAB strains for humans.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"37 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Antiviral Activity of Polyphenols 多酚类物质的抗病毒活性

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-01 DOI: 10.1002/mnfr.70042

Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu

{"title":"The Antiviral Activity of Polyphenols","authors":"Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu","doi":"10.1002/mnfr.70042","DOIUrl":"https://doi.org/10.1002/mnfr.70042","url":null,"abstract":"Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a wide range of employment, from food production to medical usages. Among the beneficial applications of polyphenols, their antiviral activity is gaining importance due to the increased prevalence of drug-resistant viruses such as herpes and hepatitis B viruses. In the present review, we provide an overview of the most promising or commonly used antiviral polyphenols and their mechanisms of action focusing on their effects on enveloped viruses of clinical importance (double-stranded linear or partially double-stranded circular DNA viruses, negative sense single-stranded RNA viruses with nonsegmented or segmented genomes, and positive sense single-stranded RNA viruses). The present work emphasizes the relevance of polyphenols, in particular epigallocatechin-3-gallate and resveratrol, as alternative or supportive antivirals. Polyphenols could interfere with virtually all steps of viral infection, from the adsorption to the release of viral particles. The activity of polyphenols against viruses is especially relevant given the risk of widespread outbreaks associated with viruses, remarked by the recent COVID-19 pandemic.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 7'25 发布信息：Mol. Nutr。Food Res. 7'25

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-04-01 DOI: 10.1002/mnfr.70036

引用次数: 0

Protective Effects of Flavonoids in Diabetic Cardiomyopathy: A Comprehensive Review on the Mechanistic Insights 黄酮类化合物对糖尿病性心肌病的保护作用：机制综述

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-03-31 DOI: 10.1002/mnfr.70038

Sonia Ramos

引用次数: 0