Molecular Nutrition & Food Research最新文献_第7页

Polyphenols as Systems Modulators of the Gut-Brain-Liver Axis: A Narrative Review of Neuro-Metabolic and Immunomodulatory Networks 多酚作为肠-脑-肝轴的系统调节剂：神经代谢和免疫调节网络的叙述综述。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-09 DOI: 10.1002/mnfr.70560

Aftab Alam, Talha Jawaid

{"title":"Polyphenols as Systems Modulators of the Gut-Brain-Liver Axis: A Narrative Review of Neuro-Metabolic and Immunomodulatory Networks","authors":"Aftab Alam, Talha Jawaid","doi":"10.1002/mnfr.70560","DOIUrl":"10.1002/mnfr.70560","url":null,"abstract":"<div>\u0000 \u0000 Dietary polyphenols are gaining attention as regulators of gut-brain-liver (GBL) signaling in metabolic disease. The objective of this narrative review is to examine how polyphenols affect neuro-metabolic and immune pathways across the gut-brain-liver axis in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease. The review covers literature from 2000 to 2025 indexed in PubMed, Scopus, and Web of Science, with emphasis on mechanistic, multi-omics, preclinical, and human studies. Most polyphenols show poor absorption in the gastrointestinal tract and depend on liver enzymes and intestinal microorganisms for conversion into active metabolites, including urolithins, phenyl-γ-valerolactones, equol, and other phenolic acids. These metabolites influence microbial composition, bile acid signaling, gut hormone secretion, and host processes related to oxidative stress, inflammation, energy balance, and mitochondrial function. In animal and cell models, polyphenols reduce hepatic fat accumulation, improve insulin sensitivity, strengthen gut barrier integrity, and lower endotoxemia. Human evidence remains limited, derived mainly from short-term trials with considerable inter-individual variability. This variability appears linked to metabotype, metabolic capacity, habitual diet, sex, and medication use. Overall, current evidence supports polyphenols as multi-target regulators of gut-brain-liver communication. Larger, well-designed clinical and translational studies are needed to confirm their therapeutic relevance.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Fatty Acids Differentially Modulate Hippocampal Glutamate-Related Gene Expression in Mice: Sex-Specific in Vivo and in Vitro Effects 膳食脂肪酸对小鼠海马谷氨酸相关基因表达的差异调节：体内和体外性别特异性影响

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-09 DOI: 10.1002/mnfr.70580

Laura Romero-Muñoz, Beatriz Merino, Enrique Sánchez-Hita, Ana Belén Sanz-Martos, María E. Casado, Mónica Domingo-Martínez, Adrián Plaza, Lidia Morales, Antonia García, Constanza Fernández-Hernández, Jesús Fernández-Felipe, Nuria Del Olmo, Alberto Marcos, Julie A. Chowen, Mariano Ruiz-Gayo, Victoria Cano

{"title":"Dietary Fatty Acids Differentially Modulate Hippocampal Glutamate-Related Gene Expression in Mice: Sex-Specific in Vivo and in Vitro Effects","authors":"Laura Romero-Muñoz, Beatriz Merino, Enrique Sánchez-Hita, Ana Belén Sanz-Martos, María E. Casado, Mónica Domingo-Martínez, Adrián Plaza, Lidia Morales, Antonia García, Constanza Fernández-Hernández, Jesús Fernández-Felipe, Nuria Del Olmo, Alberto Marcos, Julie A. Chowen, Mariano Ruiz-Gayo, Victoria Cano","doi":"10.1002/mnfr.70580","DOIUrl":"10.1002/mnfr.70580","url":null,"abstract":"<div>\u0000 \u0000 High-fat diets (HFDs) disrupt hippocampal (HIP) glutamatergic transmission, reducing synaptic plasticity and contributing to cognitive decline. While excessive dietary fat is known to alter glutamate (Glu) homeostasis, the specific effects of saturated versus unsaturated fatty acids and the role of sex remain unclear. We examined two HFDs, one enriched in oleic acid (OA) (UOLF, unsaturated) and another in palmitic and lauric acids (LAs) (SOLF, saturated), in young adult male and female mice. In males, both diets increased HIP Glu and glutamine (Gln) levels; however, only UOLF upregulated genes linked to Glu/Gln uptake and synthesis, suggesting an adaptive metabolic response. These changes were absent in females, indicating marked sex-dependent effects. In cultured HIP neurons and astrocytes, OA caused milder alterations than palmitic acid (PA) and selectively activated pathways that may lower extracellular Glu and enhance recycling. Lauric acid (LA) failed to activate protective mechanisms, implying it is a major driver of HIP dysfunction in males consuming saturated fats. Both diets disrupted the HIP Glu-Gln cycle in males, but only unsaturated fats triggered compensatory mechanisms that mitigate Glu accumulation. These findings emphasize the critical role of dietary fat composition and biological sex in shaping HIP Glu metabolism and glutamatergic function.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Probiotic Supplementation on Circadian Rhythm-Related Gene Expression and Body Weight in Mice With Disturbed Circadian Rhythms 补充益生菌对昼夜节律紊乱小鼠昼夜节律相关基因表达和体重的影响

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-06 DOI: 10.1002/mnfr.70579

Büşra Tepebaşı, Mehtap Ünlü Söğüt, Menşure Nur Çelik, Sevtap Kabalı

{"title":"Effects of Probiotic Supplementation on Circadian Rhythm-Related Gene Expression and Body Weight in Mice With Disturbed Circadian Rhythms","authors":"Büşra Tepebaşı, Mehtap Ünlü Söğüt, Menşure Nur Çelik, Sevtap Kabalı","doi":"10.1002/mnfr.70579","DOIUrl":"10.1002/mnfr.70579","url":null,"abstract":"Given the limited knowledge of probiotic effects on clock genes, this study investigated whether probiotics that regulate gut integrity and microbiota balance influence central circadian clock gene expression. In this study conducted on three groups [control group (CG), shifted group (SG), and shifted and probiotic supplement group (SPG)] of eight BALB/c mice each, Clock, Bmal1, and Per2 gene expressions and weight gain were evaluated. Although body weights at baseline, week 8, and week 16 were similar among groups, weight gain over time was significantly higher in the SG and SPG groups (p<0.05). Significant differences were observed between CG and SG at week 8 and between SG and SPG at week 16. Gene expression analyses revealed no significant differences in Clock expression. However, Bmal1 expression at ZT18 was significantly different between the CG and SPG groups (p = 0.045). These findings demonstrate the regulatory effect of probiotic supplementation on circadian disruption and weight gain, suggesting a potential role in circadian rhythm management. Nevertheless, the results should be interpreted cautiously because they are based on limited gene expression changes and require confirmation in larger studies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13448095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenolic-Rich Lentil Extracts Regulate Cytokine Production, Metabolic Pathways and Barrier Function in Intestinal Epithelial Cells 富含酚的扁豆提取物调节肠上皮细胞的细胞因子产生、代谢途径和屏障功能。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-06 DOI: 10.1002/mnfr.70572

Rafaela Geraldo, Manuela Machado, Eduardo Costa, Simão Pinho, Alexandra Gouveia, Delminda Neves, Victor Freitas, Elisabete Pinto, Manuela Pintado, Marta W. Vasconcelos

{"title":"Phenolic-Rich Lentil Extracts Regulate Cytokine Production, Metabolic Pathways and Barrier Function in Intestinal Epithelial Cells","authors":"Rafaela Geraldo, Manuela Machado, Eduardo Costa, Simão Pinho, Alexandra Gouveia, Delminda Neves, Victor Freitas, Elisabete Pinto, Manuela Pintado, Marta W. Vasconcelos","doi":"10.1002/mnfr.70572","DOIUrl":"10.1002/mnfr.70572","url":null,"abstract":"<div>\u0000 \u0000 Phenolic compounds are recognized for antioxidant, anti-inflammatory, and antidiabetic properties. Lentils are abundant in these compounds, yet comparative studies across varieties and intestinal cells effects remain limited. This study evaluated the nutritional composition, phenolic profile, antioxidant activity, and α-glucosidase inhibition of four lentil types in raw and cooked forms. L01 had the highest bioactive potential and was the only one selected for further evaluation in Caco-2 cells under basal and IL-1β-stimulated conditions. Cooking altered composition, leading to higher protein, fiber, and carbohydrates, reducing tannins, and maintaining high phytic acid in some varieties. L01 consistently showed the highest phenolic content, antioxidant activity, and enzyme inhibition. Its phenolic profile was dominated by kaempferol derivatives, (epi)catechin, and procyanidins, with cooking increasing monomeric catechins but reducing procyanidin oligomers. At noncytotoxic levels, L01 extracts reduced IL-6/8 secretion in stimulated cells, with stronger effects from raw extracts. Additionally, they decreased expression of inflammatory markers (IL-6/8/1β) while increasing expression of metabolic regulation- and barrier-related genes (Peroxisome proliferator-activated receptor-γ, Sirtuin 1, Occludin, and Cadherin-1). Only raw extracts significantly enhanced Heme oxygenase-1 expression under stimulation. These findings highlight compositional differences beyond tegument color and support further investigation of phenolic-rich lentils as potential functional food ingredients targeting gut and metabolic health.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults DASH饮食、膳食硝酸盐和一氧化氮的生物利用度：对老年人内皮功能障碍和高血压的影响。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-06 DOI: 10.1002/mnfr.70569

Ruhui Zhong, Yuxin Guo, Xinyi You, Junjie Fu, Jingyi Liu, Yuxi Wen, Jiahui Wen, Chao Zhao

{"title":"DASH Diet, Dietary Nitrate, and Nitric Oxide Bioavailability: Implications for Endothelial Dysfunction and Hypertension in Older Adults","authors":"Ruhui Zhong, Yuxin Guo, Xinyi You, Junjie Fu, Jingyi Liu, Yuxi Wen, Jiahui Wen, Chao Zhao","doi":"10.1002/mnfr.70569","DOIUrl":"10.1002/mnfr.70569","url":null,"abstract":"<div>\u0000 \u0000 Hypertension in the elderly is closely associated with vascular aging, characterized by endothelial dysfunction (ED) and a progressive decline in nitric oxide (NO) bioavailability. Age-related dysfunction of endothelial nitric oxide synthase (eNOS), compounded by increased oxidative stress, creates a vicious cycle of oxidative–nitrosative imbalance, leading to chronic inflammation and arterial stiffness. The Dietary Approaches to Stop Hypertension (DASH) diet was developed as a primary intervention to restore NO balance by protecting endogenous pathways and supplying alternative nitrate–nitrite–NO precursors. However, its cardiovascular benefits are often diminished by age-related alterations in nitrate metabolism and the extensive use of multiple medications in the elderly. Thus, while restoring balance remains a key therapeutic goal, future clinical strategies must evolve from broad dietary recommendations to more personalized, precise nutritional approaches, considering the unique physiological and pharmacological challenges faced by older adults.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat-Killed Bifidobacterium longum ZFML0012 Alleviates Rheumatoid Arthritis via Gut–Joint Axis Regulation: Remodeling Microbiota, Boosting SCFAs/L-Glutamine, and Rebalancing Th17/Treg Immunity 热杀长双歧杆菌ZFML0012通过调节肠道-关节轴缓解类风湿关节炎：重塑微生物群，提高SCFAs/ l -谷氨酰胺，重新平衡Th17/Treg免疫。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-05 DOI: 10.1002/mnfr.70566

Tiantian Yang, Yubin Zhang, Yingjie Huang, La Xi, Bin Yu, Zeren Cheng, Fengxuan Wang, Yimin Li, Qing Gu, Ping Li

{"title":"Heat-Killed Bifidobacterium longum ZFML0012 Alleviates Rheumatoid Arthritis via Gut–Joint Axis Regulation: Remodeling Microbiota, Boosting SCFAs/L-Glutamine, and Rebalancing Th17/Treg Immunity","authors":"Tiantian Yang, Yubin Zhang, Yingjie Huang, La Xi, Bin Yu, Zeren Cheng, Fengxuan Wang, Yimin Li, Qing Gu, Ping Li","doi":"10.1002/mnfr.70566","DOIUrl":"10.1002/mnfr.70566","url":null,"abstract":"<div>\u0000 \u0000 Rheumatoid arthritis (RA) is an autoimmune disease closely associated with gut microbiota dysbiosis. Amid growing interest in microbial-derived therapeutics, postbiotics, defined as preparations of nonliving microorganisms and/or their components conferring host benefits, have emerged as candidates. However, the immunomodulatory potential of Bifidobacteria postbiotics in RA remains unexplored. This study investigated the effects of heat‑killed Bifidobacterium longum ZFML0012 (HK‑B. longum) on RA and its underlying mechanisms using in vitro and in vivo models. In LPS-induced cells, HK-B. longum significantly suppressed the expression of pro-inflammatory cytokines such as IL-1β and TNF-α while promoting the anti-inflammatory factor IL-10. In collagen-induced arthritis (CIA) mice, it reduced arthritis scores, joint swelling, and bone erosion. Mechanistically, HK-B. longum remodeled gut microbiota, increased SCFAs (acetate and butyrate), and particularly upregulated the immunomodulatory metabolite L-Glutamine in both gut and serum. In vitro experiments confirmed that L-Glutamine inhibited TNF‑α‑induced inflammation, abnormal proliferation, and migration in MH7A synovial cells. Meanwhile, HK‑B. longum regulated the T helper cell 17/Regulatory T cell (Th17/Treg) immune imbalance, modulated local inflammatory factors, and restored the osteoprotegerin/receptor activator of nuclear factor‑κB ligand (OPG/RANKL) ratio in joints. These findings provide new evidence for using postbiotics to alleviate RA through gut–joint axis regulation.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Methoxyl Pectin Consistently Reduces β-Carotene Bioaccessibility Across Various Gastrointestinal Digestion Conditions 高甲氧基果胶持续降低β-胡萝卜素在各种胃肠道消化条件下的生物可及性。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-05 DOI: 10.1002/mnfr.70562

Anushka Shukla, Thomas Schleeh, Patrick Borel, Charles Desmarchelier, Torsten Bohn

{"title":"High Methoxyl Pectin Consistently Reduces β-Carotene Bioaccessibility Across Various Gastrointestinal Digestion Conditions","authors":"Anushka Shukla, Thomas Schleeh, Patrick Borel, Charles Desmarchelier, Torsten Bohn","doi":"10.1002/mnfr.70562","DOIUrl":"10.1002/mnfr.70562","url":null,"abstract":"Dietary fiber could inhibit β-carotene bioaccessibility by restricting its release from the food matrix, interfering with digestive enzyme activities, binding bile salts, or modifying viscosity and other physicochemical properties of the digesta. In this study, we investigated whether high methoxyl pectin (HMP), a soluble dietary fiber found in fruits/vegetables and an additive for the food industry would impact β-carotene bioaccessibility under various physiological digestive conditions, following the INFOGEST gastrointestinal model. Concentrations of pancreatin plus bile salts and shear forces (simulated by varying water bath rounds/min. and glass bead addition) were modified in the presence (1.15 mg/mL digesta) and absence of HMP. Endpoints measured in the digesta included β-carotene bioaccessibility, surface tension, viscosity, micelle size, zeta potential, and triglyceride lipolysis. Adding HMP reduced overall bioaccessibility of β-carotene from 32.1±6.2% to 24.1±5.7% (p<0.001). All other parameters also had a significant impact on the bioaccessibility of β-carotene, that is, bile/pancreatin concentration (p<0.001), water bath shaking speed (p<0.001), and glass beads (p = 0.001). Surface tension, viscosity, and micelle size were less strongly affected by HMP addition (p<0.05), though not triglyceride lipolysis. The inhibitory effect of HMP varied depending on bile/pancreatin concentration and shear-forces, with strongest reductions when β-carotene bioaccessibility was highest at onset.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Citrus Peel Xanthophylls Orchestrate Lipid–Glucose–Inflammation Axis Reprogramming in Cardiometabolic Syndrome: Integrative In Silico and In Vivo Evidence 柑橘皮叶黄素在心脏代谢综合征中协调脂-葡萄糖-炎症轴重编程：综合的计算机和体内证据。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-04 DOI: 10.1002/mnfr.70576

Muhammad Reva Aditya, Muhammad Yusuf, Kanandya Kizzandy, Rizki Hari Mulia, Agnes Vianne, Athaya Rahmanardi Muhammad, Davina Shafa Aviantiputri, Adha Fauzi Hendrawan, Ade Meidian Ambari, Dante Saksono Harbuwono, Antonello Santini, Fahrul Nurkolis

{"title":"Citrus Peel Xanthophylls Orchestrate Lipid–Glucose–Inflammation Axis Reprogramming in Cardiometabolic Syndrome: Integrative In Silico and In Vivo Evidence","authors":"Muhammad Reva Aditya, Muhammad Yusuf, Kanandya Kizzandy, Rizki Hari Mulia, Agnes Vianne, Athaya Rahmanardi Muhammad, Davina Shafa Aviantiputri, Adha Fauzi Hendrawan, Ade Meidian Ambari, Dante Saksono Harbuwono, Antonello Santini, Fahrul Nurkolis","doi":"10.1002/mnfr.70576","DOIUrl":"10.1002/mnfr.70576","url":null,"abstract":"Cardiometabolic syndrome (CMS) involves interconnected dysregulation of lipid, glucose, and inflammatory pathways. Citrus peel, an agro-industrial byproduct, is rich in xanthophylls with potential multitarget effects, yet their integrated mechanisms remain unclear. This study aimed to investigate the mechanistic basis and therapeutic efficacy of a citrus peel xanthophyll fraction (CPXF) in modulating the lipid–glucose–inflammation axis through integrated in silico and in vivo approaches. CPXF was characterized via UHPLC–HRMS/MS. Network pharmacology and molecular docking identified target interactions. In vivo validation was conducted in high-fat diet plus fructose-induced CMS rats, evaluating metabolic, inflammatory, oxidative, and gene expression parameters. β-cryptoxanthin, violaxanthin, and lutein were dominant compounds. Key targets included PPARG, AMPK, SREBP1, and MMP9, with strong binding affinities (ΔG up to −10.3 kcal/mol). CPXF significantly improved glucose homeostasis, insulin resistance, lipid profile, and OGTT outcomes. It reduced TNF-α, IL-6, and CRP, attenuated oxidative stress (↓MDA; ↑SOD, CAT, GSH), and restored hepatic function. Gene expression analysis showed upregulation of Ampk and Pparg and suppression of Srebp1c. CPXF exerts synergistic, multitarget effects across the lipid–glucose–inflammation axis via AMPK activation, PPAR-γ modulation, and SREBP-1c suppression, supporting its potential as a food-derived strategy for CMS management.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13434363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148667735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Therapeutic Use of Natural Products in Myopia Prevention: Recent Applications 天然产物在近视预防中的治疗应用：最新应用

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-07-30 DOI: 10.1002/mnfr.70568

Gaolei Wang, Cong Ren, Xiaoyun Dong, Lianghui Zhao, Bin Guo

引用次数: 0

The Preventive Effect of Introducing Glutamine on Chemotherapy-Induced Diarrhea in Colorectal Cancer and Its Influence on Inflammatory Factors Such as CRP and IL-6 谷氨酰胺对结直肠癌化疗性腹泻的预防作用及其对CRP、IL-6等炎症因子的影响

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-07-30 DOI: 10.1002/mnfr.70536

Jianwei Zhu, Yang Liu

{"title":"The Preventive Effect of Introducing Glutamine on Chemotherapy-Induced Diarrhea in Colorectal Cancer and Its Influence on Inflammatory Factors Such as CRP and IL-6","authors":"Jianwei Zhu, Yang Liu","doi":"10.1002/mnfr.70536","DOIUrl":"https://doi.org/10.1002/mnfr.70536","url":null,"abstract":"<div>\u0000 \u0000 To assess the protective effects of live combined bifidobacterium, lactobacillus, enterococcus, and glutamine on diarrhea associated with chemotherapy and inflammatory markers in colorectal cancer patients (CCP). A retrospective analysis was conducted on the clinical data of patients with colorectal cancer who received chemotherapy at the People's Hospital of Pailin County, Chongqing from December 2022 to December 2024. There were 59 cases in the control group and 59 cases in the study group. The control group received treatment with triple live bifidobacterium, while the study group received combined treatment with glutamine in addition to the treatment of the control group. We compared levels of inflammatory markers, intestinal barrier functions, immune responses, and diarrhea incidence during chemotherapy. No significant pre-chemotherapy differences were noted in inflammatory or intestinal barrier markers (P > 0.05). Throughout the course of treatment, we observed a reduction in inflammatory markers in both groups (P < 0.05), with the experimental group showing more significant declines. Intestinal barrier functions degraded over time in both groups, with more significant reductions in the study group (P < 0.05). The therapy combining significantly mitigates inflammation, bolsters intestinal and immune functions, and alleviates diarrhea in CCP.\u0000 Clinical Registration: The authors have nothing to report.\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 15","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148616976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0