Molecular Nutrition & Food Research最新文献_第6页

Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention-Deficit/Hyperactivity Disorder. 含有动物双歧杆菌亚种的益生菌混合物的有效性和安全性。注意缺陷/多动障碍儿童乳酸杆菌BLa80和鼠李糖乳酸杆菌LRa05

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70234

Qianqian Niu, Wen Wang, Yan Liang, Shuguang Fang, Lin Wan, Guang Yang

{"title":"Efficacy and Safety of a Probiotic Mixture Containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in Children With Attention-Deficit/Hyperactivity Disorder.","authors":"Qianqian Niu, Wen Wang, Yan Liang, Shuguang Fang, Lin Wan, Guang Yang","doi":"10.1002/mnfr.70234","DOIUrl":"https://doi.org/10.1002/mnfr.70234","url":null,"abstract":"Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder. Emerging evidence suggests that gut microbiota may contribute to ADHD pathogenesis and that microbiota modulation could improve its symptoms. This study evaluated the safety and efficacy of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 in children with ADHD. An open-label, single-arm trial enrolled children with ADHD (n = 42) who received daily oral probiotics (5 × 109 CFU) for 8 weeks. BRIEF-II and SNAP-IV scales were administered at baseline, Week 5, and Week 9 to assess changes in symptoms. Probiotic intervention significantly reduced scores in BRIEF-II domains (Global Executive Composite, Behavior Regulation Index, Emotion Regulation Index, and Cognitive Regulation Index) and SNAP-IV subscales (Inattention, Hyperactivity-Impulsivity) at Week 9 (all p < 0.05). One participant experienced mild diarrhea (grade 1, resolved spontaneously). No significant changes in hematological/biochemical parameters were observed. This exploratory study found that the probiotic mixture is safe and may improve ADHD symptoms in children, warranting further controlled trials to validate its efficacy and explore the underlying mechanisms. This study has been registered in a clinical trial registry. Trial Registration: ClinicalTrials.gov identifier: NCT06348121.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70234"},"PeriodicalIF":4.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blueberry Anthocyanins Ameliorate Obesity‐Induced Dysfunction of Lipid Metabolism and Gut Microbiota by Inhibiting TLR4 Pathway 蓝莓花青素通过抑制TLR4通路改善肥胖诱导的脂质代谢和肠道微生物群功能障碍

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70244

Xingyu Zhao, Jiawei Zheng, Zhigang Tu, Xinyu Li, Bin Li, Wuyang Huang

{"title":"Blueberry Anthocyanins Ameliorate Obesity‐Induced Dysfunction of Lipid Metabolism and Gut Microbiota by Inhibiting TLR4 Pathway","authors":"Xingyu Zhao, Jiawei Zheng, Zhigang Tu, Xinyu Li, Bin Li, Wuyang Huang","doi":"10.1002/mnfr.70244","DOIUrl":"https://doi.org/10.1002/mnfr.70244","url":null,"abstract":"Blueberry anthocyanins demonstrate promising anti‐obesity potential, however, their mechanism remains underexplored. This investigation revealed Toll‐like receptor 4 (TLR4), an immune receptor recently found to involve in insulin resistance, as a critical mediator of these effects.Male wild‐type (WT) and TLR4 gene knockout (TLR4−/−) mice were used to establish obesity model and investigate the anti‐obesity effects of blueberry anthocyanin extracts (BAE) based on TLR4. Body weight, glucose tolerance, liver lipid metabolism, TLR4/adenosine monophosphate‐activated protein kinase (AMPK) signaling pathway, gut microbiota, and their metabolite levels were evaluated. The results demonstrated that BAE significantly attenuated weight gain, hepatic steatosis, and dyslipidemia in WT mice. However, these therapeutic benefits were abolished in TLR4−/− mice despite observing baseline reductions in hepatic lipid accumulation with TLR4 knockout alone. Moreover, BAE regulated gut microbiota composition and enhanced short‐chain fatty acids (SCFAs) production in WT mice. Notably, TLR4 deficiency independently induced gut microbiota alterations.These findings revealed a novel mechanism whereby BAE ameliorate obesity‐associated metabolic dysfunction through TLR4 pathway inhibition, concurrently addressing lipid metabolism impairments and gut microbiota dysbiosis. This study advances TLR4‐targeted therapeutic strategies using blueberry anthocyanins, offering a multimodal approach to obesity management that integrates metabolic regulation with microbiome modulation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"162 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming 以地中海饮食为基础的食物组合通过线粒体和代谢重编程改善糖尿病和肥胖相关的肝脏改变

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70210

Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri

{"title":"A Mediterranean Diet‐Based Food Mix Ameliorates Diabetes‐ and Obesity‐Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming","authors":"Giovanna Mercurio, Antonia Giacco, Antonio Dario Troise, Moira Ledbetter, Sabrina De Pascale, Nicla Scopigno, Michela Vigliotti, Matteo Mazzola, Giuseppe Riccio, Andrea Scaloni, Maria Moreno, Alberto Fiore, Federica Cioffi, Elena Silvestri","doi":"10.1002/mnfr.70210","DOIUrl":"https://doi.org/10.1002/mnfr.70210","url":null,"abstract":"Metabolic syndrome (MetS)‐related diseases, such as type 2 diabetes (T2D) and obesity, are among the leading causes of liver damage, and their prevalence poses an increasing clinical challenge. The Mediterranean diet (MD) has shown promising effects in managing MetS, reducing mortality and morbidity. However, the precise biochemical and molecular mechanisms underlying the MD efficacy remain unclear. This study evaluated the effects of a lab‐designed balanced food mix, simulating the 1960s MD, on hepatic metabolic dysfunction in obese and diabetic db/db mice.The MD cocktail, naturally rich in polyphenols, fructose, and monounsaturated fatty acids, prevented hyperlipidemia while not reversing diabetes and obesity. Gene expression, protein representation, and metabolomic analyses of liver tissues from MD‐fed db/db mice revealed reduced oxidative damage, preserved mitochondrial quality control, enhanced autophagy markers, and reduced fibrosis markers. The MD cocktail also enhanced liver mitochondrial mass and stimulated the OXPHOS system. It also preserved the hepatic pool of acylated carnitine derivatives and chenodeoxycholic acid, suggesting protective effects on mitochondrial β‐oxidation and bile acid biosynthesis, with an overall improvement of metabolite profiles.The experimental MD cocktail exerted significant hepatoprotective effects, mitigating several diabetes‐ and obesity‐induced hepatic disturbances and beneficially affecting metabolic fluxes and tissue texture.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"24 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Cell‐Type‐Specific Immune Reactions in Human Blood Following Varied Fruit and Vegetable Blends Interventions 揭示不同水果和蔬菜混合干预后人类血液中细胞类型特异性免疫反应

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70238

Yueqin He, Julia N. DeBenedictis, Simone G. van Breda, Theo M. de Kok

{"title":"Unveiling Cell‐Type‐Specific Immune Reactions in Human Blood Following Varied Fruit and Vegetable Blends Interventions","authors":"Yueqin He, Julia N. DeBenedictis, Simone G. van Breda, Theo M. de Kok","doi":"10.1002/mnfr.70238","DOIUrl":"https://doi.org/10.1002/mnfr.70238","url":null,"abstract":"A diet rich in fruits and vegetables (F&Vs) reduces chronic disease risk by modulating oxidative stress, inflammatory cytokines, and immune cell activity in the blood. Given the complexity of peripheral blood and its cellular components, understanding cell‐type‐specific responses to F&V interventions remains essential and challenging. We used CIBERSORTx to analyze immune cell fractions and gene expression profiles from RNA sequencing data of the MiBLEND study, which assessed the impact of seven F&V blends on chronic disease markers, phytochemical absorption, and gene expression changes in blood. Analysis of white blood cells (WBCs) showed no significant changes in proportions of major leukocyte types. CIBERSORTx determined proportions of 22 leukocyte subtypes, correlating with traditional WBC composition. Paired t tests revealed that blends higher in carotenoids, anthocyanins, or complex phytochemicals altered CD4+/CD8+ T cell ratios. A strong positive association was observed between the proportion of memory B cells and beta‐carotene levels in peripheral blood following the consumption of Blend 1. Finally, DEGs and pathway analyses showed that some blends affected DNA repair in B cells, NF‐kappa B signaling in plasma cells, and endocytosis in dendritic cells (DCs) and natural killer (NK) cells. These findings offer clearer insight into immune cell dynamics in blood following F&V interventions, clarifying immune mechanisms involved in their preventive effects.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"29 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential of Vitamin D and Epigallocatechin Gallate (EGCG) for the Treatment of Uterine Fibroids: Evidence From In Vitro to Clinical Studies 维生素D和没食子儿茶素没食子酸酯（EGCG）治疗子宫肌瘤的潜力：从体外到临床研究的证据

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70231

Ioanna Ploumaki, Samya El Sayed, Awurakua Asamoah‐Mensah, Valeria I. Macri, James H. Segars, Md Soriful Islam

{"title":"The Potential of Vitamin D and Epigallocatechin Gallate (EGCG) for the Treatment of Uterine Fibroids: Evidence From In Vitro to Clinical Studies","authors":"Ioanna Ploumaki, Samya El Sayed, Awurakua Asamoah‐Mensah, Valeria I. Macri, James H. Segars, Md Soriful Islam","doi":"10.1002/mnfr.70231","DOIUrl":"https://doi.org/10.1002/mnfr.70231","url":null,"abstract":"Uterine fibroids are prevalent benign tumors of the female reproductive tract that cause significant morbidity. Accumulating evidence suggests an association between vitamin D deficiency and uterine fibroid prevalence. Vitamin D, synthesized through sunlight exposure and obtained from fatty fish and fortified foods, regulates key processes, such as cell proliferation and apoptosis. In vitro and in vivo studies have demonstrated the efficacy of vitamin D against uterine fibroids. Clinical evidence further supports its role in fibroid management, as evidenced by a decrease in fibroid incidence, volume, and growth rate. Similarly, EGCG, a major polyphenol in green tea, inhibits cell proliferation and fibrosis while inducing apoptosis. Both in vitro and in vivo studies reveal the potential of EGCG in fibroid treatment, with clinical trials corroborating these findings. Given their complementary mechanisms, a synergistic effect of combined vitamin D and EGCG treatment has been explored. Preliminary clinical evidence indicates promising results, including reduction in fibroid volume, improved surgical outcomes, and enhanced quality of life. This review synthesizes current knowledge of vitamin D and EGCG mechanisms of action, presents preclinical and clinical evidence, and discusses the emerging evidence for their combination therapy as a non‐invasive, cost‐effective treatment strategy for uterine fibroids.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"26 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction and Purification of Tropomyosin From Crabs Scylla olivacea and Charybdis ferriatus: Assessment of Allergenicity and Sensitizing Capacity Using Animal Experimental Model 蟹蟹蟹蟹中原肌球蛋白的提取纯化：动物实验模型的致敏性和致敏性评价

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70240

Neha Omgy, Rangasamy Anandan, Sankar Thazhakot Vasunambesan, Vijay Kumar Reddy Surasani, Celine Hilda Mary Savari Arockiam, Manjanaik Bojayanaik, Veena Shetty Alandur, Ambrose Paulraj, Pavan Kumar Dara

{"title":"Extraction and Purification of Tropomyosin From Crabs Scylla olivacea and Charybdis ferriatus: Assessment of Allergenicity and Sensitizing Capacity Using Animal Experimental Model","authors":"Neha Omgy, Rangasamy Anandan, Sankar Thazhakot Vasunambesan, Vijay Kumar Reddy Surasani, Celine Hilda Mary Savari Arockiam, Manjanaik Bojayanaik, Veena Shetty Alandur, Ambrose Paulraj, Pavan Kumar Dara","doi":"10.1002/mnfr.70240","DOIUrl":"https://doi.org/10.1002/mnfr.70240","url":null,"abstract":"Tropomyosin is a significant allergen found in invertebrates and is recognized as one of the primary triggers of food‐induced anaphylaxis. Though many researchers have done the characterization of allergic tropomyosin, a comparative analysis of the allergenicity of vertebrate (porcine) and invertebrate (crab) tropomyosin is still lacking. The present study aims to study the differences in IgE, tropomyosin‐specific IgE, and histamine levels between vertebrate (porcine) and invertebrate tropomyosin (crab) using an animal experimental model. Tropomyosin was extracted from two selected crabs, marine water (Scylla olivacea) and freshwater (Charybdis ferriatus). A high level of systemic anaphylactic reactions was observed in the mice groups treated with crab tropomyosin. In addition, high levels of IgE, tropomyosin‐specific IgE, and histamine levels as revealed by ELISA (Enzyme‐Linked Immunosorbent Assay) analysis. Histopathological examination exhibited changes in the liver and gastrointestinal regions of the mice groups treated with crab tropomyosin. The variations in the amounts of transcription factors like T‐bet, GATA‐3, and Foxp3 were also evaluated through gene expression analysis. The presence of GATA‐3′ transcription factor was also identified in the spleen of mice treated with crab tropomyosin. This study helps for the better diagnosis and treatment of food allergies, especially shellfish allergies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"31 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Polysaccharide PPS3 From Pumpkin Alleviates High Fat Diet‐Induced Obesity in Mice by Activating the AMPK Signaling Pathway and Regulating the Gut Microbiota 南瓜多糖PPS3通过激活AMPK信号通路和调节肠道微生物群减轻高脂肪饮食诱导的小鼠肥胖

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70245

Haizhao Song, Yubo Cao, Qianqian Huang

{"title":"The Polysaccharide PPS3 From Pumpkin Alleviates High Fat Diet‐Induced Obesity in Mice by Activating the AMPK Signaling Pathway and Regulating the Gut Microbiota","authors":"Haizhao Song, Yubo Cao, Qianqian Huang","doi":"10.1002/mnfr.70245","DOIUrl":"https://doi.org/10.1002/mnfr.70245","url":null,"abstract":"This study evaluated the beneficial effects of pumpkin polysaccharide (PPS3) on diet‐induced obesity in mice and explored its underlying mechanisms.In a 10‐week study, PPS3 significantly reduced body weight without affecting food or water intake, indicating a direct metabolic effect. PPS3 improved lipid and glucose metabolism by lowering serum triglycerides, total cholesterol, and non‐esterified fatty acids, while increasing HDL cholesterol and enhancing glucose tolerance. It also exhibited hepatoprotective effects by reducing hepatic lipid accumulation and mitigating liver damage. Mechanistically, PPS3 activated the AMPK signaling pathway, promoting fatty acid oxidation and lipolysis, while inhibiting lipogenesis via modulation of key regulators such as PPARα, PPARγ, SREBP‐1c, and ACC. Additionally, PPS3 modulated gut microbiota diversity and composition, reversing high‐fat diet‐induced dysbiosis by increasing beneficial genera (Akkermansia and Parabacteroides), lowering the Firmicutes/Bacteroidota ratio, and reducing harmful bacteria linked to obesity. Metabolomic analysis revealed enrichment of metabolites like 18β‐Glycyrrhetinic acid and nonanoic acid, which may contribute to anti‐obesity effects. PPS3 also significantly modulated amino acid and lipid metabolism, promoting metabolic homeostasis. These findings highlight PPS3 as a promising beneficial agent with translational potential for obesity management, supporting further clinical investigation to address metabolic disorders in humans.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"35 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma 代谢的表观遗传调控介导紫檀芪在肝细胞癌中的抗癌作用

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70217

Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska

{"title":"AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma","authors":"Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska","doi":"10.1002/mnfr.70217","DOIUrl":"https://doi.org/10.1002/mnfr.70217","url":null,"abstract":"Disrupted metabolism, often implicated in hepatocellular carcinoma (HCC), is linked to aberrant epigenetic patterns. Dietary polyphenols, including pterostilbene (PTS), have been demonstrated to remodel epigenetic landscapes and restore metabolic homeostasis by regulating the activity of AMP‐activated protein kinase (AMPK), a protein recently shown to orchestrate a diverse set of networks to epigenetically mediate transcription. We therefore explored the mechanistic involvement of AMPK in the epigenetic effects of PTS in HCC. We incorporated PTS into a choline‐deficient amino acid defined HCC‐inducing diet (CDAA) in male Fisher‐344 rats and found significant attenuation in HCC development compared to CDAA alone. Transcriptomics by RNA‐sequencing revealed PTS‐upregulated targets, that were enriched in key metabolic processes, including the folate (Aldh1l1), methionine (Bhmt), and sarcosine (Dmdgh) cycles. PTS‐mediated gene upregulation was linked to lower levels of histone H3‐methylation at lysine 27 (H3K27me3) at gene promoters. Mechanistic studies in HCC HepG2 cells revealed that AMPK inhibition abolished epigenetic gene activation in response to PTS, which was accompanied by diminished binding of H3K27me3‐demethylase KDM6A at promoters of PTS‐target genes. Our findings provide evidence for new disease vulnerabilities that arise from epigenetic/metabolic changes and constitute novel opportunities for preventative and therapeutic success in HCC.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"45 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe‐Deficient Mice 富含生物活性化合物的特级初榨橄榄油对Apoe缺乏小鼠动脉粥样硬化的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70223

Roberto Martínez‐Beamonte, Cristina Barranquero, Laura Soler, Tania Herrero‐Continente, Anny Carolina Rondón, Carmen Arnal, Gloria Estopañán, Roberto Lasheras, María Jesús Rodriguez‐Yoldi, Joaquín Carlos Surra, Olga Martín‐Belloso, Isabel Odriozola‐Serrano, Jesús Osada, María Ángeles Navarro

{"title":"Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe‐Deficient Mice","authors":"Roberto Martínez‐Beamonte, Cristina Barranquero, Laura Soler, Tania Herrero‐Continente, Anny Carolina Rondón, Carmen Arnal, Gloria Estopañán, Roberto Lasheras, María Jesús Rodriguez‐Yoldi, Joaquín Carlos Surra, Olga Martín‐Belloso, Isabel Odriozola‐Serrano, Jesús Osada, María Ángeles Navarro","doi":"10.1002/mnfr.70223","DOIUrl":"https://doi.org/10.1002/mnfr.70223","url":null,"abstract":"To test the effects of extra virgin olive oil (EVOO) enriched in specific bioactive compounds (EVOO HBC) on atherosclerosis and fatty liver, three isocaloric Western diets differing in the type of fat (palm, EVOO, or EVOO HBC) were fed to Apoe‐deficient mice for 12 weeks. Plasma lipids, lipoprotein characterization, circulating CD36‐expressing monocytes, and M2 peritoneal macrophages were quantified. Hepatic squalene and cross‐sectional and en face atherosclerotic lesions were analyzed. Compared to the palm group, plasma triglyceride and glucose levels increased, while APOA1, paraoxonase 1 activity, and lipoprotein oxidation decreased in mice fed both EVOO groups. The latter stored liver squalene according to the amount consumed. En face and cross‐sectional atherosclerotic lesions were lower in the EVOO groups. CD36 expression in circulating monocytes was lower and M2 peritoneal macrophages were higher in the EVOO groups. In males, there was a reduced presence of CD68‐expressing cells in atherosclerotic plaques, while in females, there was a reduction in en face lesions that negatively correlated with high‐density lipoprotein (HDL)‐phospholipid efflux. The recruitment of macrophages into atherosclerotic plaques and the improvement of HDL efflux may be sex‐dependent and attributable to the high content of squalene and a specific oleuropein aglycone.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"38 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation 双歧杆菌和乳糜泻：益生菌在减少谷蛋白诱导的细胞毒性和炎症中的作用机制

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-01 DOI: 10.1002/mnfr.70222

Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck

{"title":"Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation","authors":"Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck","doi":"10.1002/mnfr.70222","DOIUrl":"https://doi.org/10.1002/mnfr.70222","url":null,"abstract":"Celiac disease (CD) is an immune‐mediated systemic disorder triggered by gluten peptides present in the diets of genetically susceptible individuals, leading to a range of intestinal and extra‐intestinal manifestations. Although managed by a gluten‐free diet (GFD), symptoms persist in 30%–50% of treated individuals despite apparent dietary compliance. Accordingly, the present review explores how bifidobacteria may mediate cytotoxic and proinflammatory responses induced by gluten‐derived peptides, contributing to the modulation of CD symptoms. Experimental in vitro studies, primarily using Caco‐2 cells and immune cell models, have shown that strains such as Bifidobacterium longum IATA‐ES1, Bifidobacterium lactis, Bifidobacterium bifidum IATA‐ES2, and B. lactis Natren Life Start super strain (NLS‐SS) can induce COX‐1 expression and reduce COX‐2, inhibit zonulin release, degrade gliadin‐derived peptides, and suppress CXCR3 mRNA expression and inflammatory mediators (e.g., TNF‐α, IFN‐γ, NF‐κB, and IL‐1β). Animal studies have provided evidence of immunomodulatory effects and improved mucosal responses, while human clinical trials have reported improvements in gastrointestinal symptoms and inflammatory markers with probiotic interventions. These findings support the potential of Bifidobacterium spp. as adjunctive agents in CD management. However, further clinical research is needed to clarify strain‐specific effects and confirm the translational relevance of these mechanisms.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"35 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0