Molecular Nutrition & Food Research最新文献

{"title":"Postbiotics Made From Selected Lactic Acid Bacteria Improves Chronic Restraint Stress-Induced Anhedonia and Sleep Disorders","authors":"Jinxing Li, Yimei Wang, Simou Wu, Zhimo Zhou, Wen Jia, Xi Shen, Yun Li, Fang He, Ruyue Cheng","doi":"10.1002/mnfr.70005","DOIUrl":"https://doi.org/10.1002/mnfr.70005","url":null,"abstract":"Sleep disorders have become one of the most prevalent neuropsychiatric disorders in recent years. This study aimed to investigate the effects of postbiotics derived from selected lactic acid bacteria on anhedonia and sleep disorders in chronic restraint stress (CRS)-induced mice, as well as their potential mechanisms. Mice were orally administered normal saline, low, medium, or high doses of postbiotics for 30 days, with CRS applied from days 1 to 21. The medium dose of postbiotics significantly increased the sucrose preference index, and the high dose of postbiotics significantly increased sleep duration. Postbiotic treatment effectively restored the diversity and composition of the gut microbiota to levels comparable to those observed in the vehicle (Veh) group. Furthermore, low and medium doses of postbiotics significantly reduced serum corticosterone levels, and medium and high doses significantly reduced serum IL-1β levels. Additionally, postbiotics administration significantly increased glutamate and GABA levels in both the prefrontal cortex and hypothalamus, as well as GABA levels in the feces. These results indicate that postbiotics alleviate CRS-induced anhedonia and sleep disorders in a dose-dependent manner. This effect may be mediated through the restoration of homeostasis in the MGB axis, HPA axis, inflammation pathways, and neurotransmitter balance.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information: Mol. Nutr. Food Res. 5'25","authors":"","doi":"10.1002/mnfr.70020","DOIUrl":"https://doi.org/10.1002/mnfr.70020","url":null,"abstract":"","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 5","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of High-Pressure Processing on Phenolic Compound Accumulation and Expression of Key Biosynthetic Genes in Harvested Strawberries","authors":"Tae Eun Kim, Jaeho Pyee","doi":"10.1002/mnfr.202400882","DOIUrl":"https://doi.org/10.1002/mnfr.202400882","url":null,"abstract":"Phytochemical accumulation plays a vital role in plant defense. This study examines the effect of high-pressure (HP) treatment on phenolic biosynthesis and gene expression in harvested strawberries, evaluating HP as a potential enhancer of phenolic biosynthesis through environmental stress responses. Strawberries were subjected to HP treatment at pressures ranging from 10 to 40 MPa in two or three cycles. This treatment led to significant increases in total phenolic content, up to 1.59 times higher than untreated controls. Gene expression analysis showed upregulation of key biosynthetic genes—phenylalanine ammonia-lyase, chalcone synthase, and UDP-glucose flavonoid 3-<i>O</i>-glucosyl transferase—with peak expression observed after three cycles of treatment at 40 MPa. HP treatment effectively enhances phenolic compound synthesis by activating biosynthetic gene expression pathways. This method presents a practical, non-genetic strategy for improving the nutritional profiles of fruits.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"34 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Skim Milk Whey-Derived Proteins on Plasma, Urine, and Gut Metabolites in Preterm Piglets as a Model for Infants","authors":"Yongxin Ye, Pingping Jiang, Karoline Aasmul-Olsen, Halise Gül Akıllıoğlu, Ann Bjørnshave, Mie Rostved Bechshøft, Marianne Nissen Lund, Per Torp Sangild, Stine Brandt Bering, Bekzod Khakimov","doi":"10.1002/mnfr.70007","DOIUrl":"https://doi.org/10.1002/mnfr.70007","url":null,"abstract":"This study investigates the metabolic impact of skim milk whey-derived protein concentrate (SPC) for infant formula, including its heat-treated (HT-SPC) and stored (HTS-SPC) variants, on the plasma, urine, and gut metabolites of newborn piglets, compared to conventional whey protein concentrate (WPC). Preterm piglets were fed formula containing WPC, SPC, HT-SPC, or HT-SPC, HTS-SPC for 5 days. Metabolomic analysis of plasma, urine, and colon content was performed using 1H NMR. Relative to WPC, SPC mainly affected colon content metabolites, increasing 19 metabolites in the colon and tyrosine in plasma, while decreasing pyruvate in colon content and glycine in plasma. Heat-treatment and storage of SPC led to increased metabolite concentrations in colon contents and urine. Notably, significant correlations between gut metabolites and abundant gut bacteria genes were observed only in the SPC-fed pigs. SPC induced higher branched chain amino acid concentrations in the gut, but had minimal effects on plasma and urinary metabolites, likely due to differences in dietary proteins and in microbiota metabolism. While the clinical effects of SPC-induced gut branched chain amino acids remain unclear, the results from our study suggest that SPC-based infant formula is metabolically safe for sensitive newborns, comparable to WPC-based formulas.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"66 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Profiles of Fecal Volatile Organic Compounds Discriminate Ulcerative Colitis Patients With an Ileoanal Pouch From Those With an Intact Colon","authors":"Chu K. Yao,&nbsp;Kraig Green,&nbsp;Alice S. Day,&nbsp;Zaid M. Ardalan,&nbsp;Rachael Slater,&nbsp;Robert V. Bryant,&nbsp;Peter R. Gibson,&nbsp;Chris Probert","doi":"10.1002/mnfr.70003","DOIUrl":"10.1002/mnfr.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Fecal volatile organic compounds (VOCs) offer insights into gut microbiota function that may drive the pathogenesis of ulcerative colitis (UC). This cross-sectional study aimed to compare dietary intake and VOC patterns in UC patients with an ileoanal pouch compared to those with an intact colon. Seven-day food records and fecal samples were collected from UC patients with an intact colon (<i>n</i> = 28) or an ileoanal pouch (<i>n</i> = 11). Fecal VOC profiles were analyzed using gas chromatography-mass spectrometry. Dietary intake in both groups was largely similar. The mean Jaccard similarity index of VOC was 0.55 (95% CI:0.53, 0.56) in the pouch compared with 0.48 (0.47, 0.49) in the colon group (<i>p</i> &lt; 0.01). A lower proportion of VOC classes was detected in the pouch, including sulfide (9% vs. 57%; <i>p</i> &lt; 0.01), branched-chain fatty acids (BCFAs; 45%–64% vs. 93%–96%; <i>p</i> &lt; 0.01), and ketones (45%–64% vs. 93%–96%; <i>p</i> &lt; 0.01), along with a higher proportion of butyric acid (91% vs. 29%; <i>p</i> &lt; 0.001). Unrelated to diet, VOC profiles show less functional diversity, reduced protein and greater carbohydrate fermentation, and altered production of secondary metabolites in the UC-pouch compared with the intact colon. These differences in the metabolic environment of the gut microbiota provide insights into pathogenesis and suggest that microbial-targeted interventions should be tailored accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal IncRNAs and circRNAs Regulated by Dietary-Lipid Stimuli","authors":"Luis A. Chapado,&nbsp;Carmen Crespo,&nbsp;Joao Tomé-Carneiro,&nbsp;Judit Gil-Zamorano,&nbsp;María-Carmen López de las Hazas,&nbsp;Ana I. Ortiz,&nbsp;Carmen Mazarío-Gárgoles,&nbsp;Daniel Sánchez-López,&nbsp;Veronique Touche,&nbsp;Henar Ortega-Senovilla,&nbsp;Sophie Lestavel,&nbsp;Olivier Briand,&nbsp;Bart Staels,&nbsp;Alberto Dávalos","doi":"10.1002/mnfr.70004","DOIUrl":"10.1002/mnfr.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>A diet rich in lipids can lead to many deleterious conditions, which involve many regulatory molecules, such as non-coding (nc)RNAs. We aimed to analyze the effects of high dietary lipid exposure on the expression of intestinal ncRNAs (long non-coding [lncRNAs] and circular [circRNAs]). lncRNAs and circRNAs were screened, both in vivo (mice) and in vitro (human intestinal organoids). In vivo, 15 lncRNAs (9 up- and 6 downregulated) and 41 circRNAs (13 up- and 28 downregulated) were modulated 3 h after a lipid challenge, while the expression of 11 lncRNAs (4 up- and 7 downregulated) was altered after 4 days of daily high-fat diet intake. In vitro, 251 up- and 387 downregulated lncRNAs, along with 19 up- and 16 downregulated circRNAs, were found 3 h after the exposure to a dietary-lipid stimulus, whereas 111 up- and 86 downregulated lncRNAs were found 24 h after exposure. Concord between the differently expressed ncRNAs found in both studies was scarce. Numerous differentially expressed lncRNAs and circRNAs have been found in response to dietary lipids both in mice and humans organoids. A potential association between many of these ncRNAs and lipid metabolism is suggested, but ncRNAs found differ greatly between humans and mice.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Polyphenols and Ascorbic Acid in Honey From Diverse Floral Origins on Liver Alcohol Metabolism","authors":"Zhiwei Sun, Lanhua Liu, Xingjiang Li, Jinjing Zhang, Hao Zhou, Dongdong Mu, Yousheng Wang, Xuefeng Wu","doi":"10.1002/mnfr.202400539","DOIUrl":"https://doi.org/10.1002/mnfr.202400539","url":null,"abstract":"Honey is known to promote alcohol metabolism effectively. However, the effects of its individual chemical components system on alcohol metabolism and their mechanisms of action have not yet been fully elucidated. We constructed polyphenols and ascorbic acid systems (PAAS) of six different floral kinds of honey by exogenous substances, to investigate their effects on alcohol metabolism in the liver. PAAS consists of 22 kinds of polyphenols (including arbutin and caffeic acid) and ascorbic acid. The results demonstrated that PAAS improved the activity of alcohol dehydrogenase (ADH) and the expression of <i>adh1</i>, but had no significant effect on acetaldehyde dehydrogenase (ALDH) and expression of <i>adh2</i>, which caused a decrease in blood ethanol concentration but no difference in acetaldehyde concentration. Correlation analysis illustrated that arbutin and trans-4-hydroxycinnamic acid in PAAS were important potential substances for promoting alcohol metabolism. In addition, PAAS could also reduce the deleterious effects of alcohol by modulating unsaturated fatty acid biosynthesis, purine metabolism, and other metabolic pathways in the liver. These findings revealed the mechanisms by which PAAS promoted hepatic alcohol metabolism as well as protected the liver and provided a theoretical basis for exploring the mechanisms in honey synergistically promote alcohol metabolism.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"82 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Impact of Omega-3 Fatty Acids and Genetic Susceptibility on Atopic Dermatitis in Adults","authors":"Rui Mao,&nbsp;Xin Meng,&nbsp;Tongtong Zhang,&nbsp;Fan Wang,&nbsp;Yun Zhong,&nbsp;Ji Li","doi":"10.1002/mnfr.70002","DOIUrl":"10.1002/mnfr.70002","url":null,"abstract":"<div>\u0000 \u0000 <p>Fatty acids (FAs) involvement in atopic dermatitis (AD) prevention is inconclusive, and the modification effect by genetic risk profiles remains unknown. The aim of this study is to explore the association between circulating FAs, genetic risk factors, and AD in adults. Utilizing the UK Biobank dataset, we evaluated the impacts of FAs on the risk of elderly-onset AD and explored the combined effects of FA levels and genetic susceptibility. Plasma omega-3 levels exhibited an inverse correlation with AD risk (hazard ratio [HR]: 0.93; 95% confidence interval [CI]: 0.89–0.98), regardless of genetic predisposition. Individuals with low genetic risk and high omega-3 levels had the lowest AD risk, a 38% reduction compared to the reference category. Additionally, individuals with GA/AA on rs1692120 exhibited a significantly elevated AD risk, whereas those with more A alleles for rs174448 demonstrated a significantly diminished AD risk (both <i>p</i> trends &lt;0.05). These findings suggest that increasing omega-3 intake could be a preventive strategy against AD, and tailoring prevention strategies based on genetic predispositions may enhance intervention efficacy.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutraceutical Blends Promote Weight Loss, Inflammation Reduction, and Better Sleep: The Role of Faecalibacterium prausnitzii in Overweight Adults–A Double-Blind Trial","authors":"Aline Boveto Santamarina, Victor Nehmi Filho, Jéssica Alves de Freitas, Lucas Augusto Moysés Franco, Roberta Cristina Martins, Joyce Vanessa Fonseca, José Antônio Orellana Turri, Mariana Tedesco Hufnagel, Daniel Pecoraro Demarque, Bruna Fernanda Rio Branco da Silva, Arianne Fagotti Gusmão, Eloísa Helena Ribeiro Olivieri, Erica de Souza, Esther Alves de Souza, José Pinhata Otoch, Ana Flávia Marçal Pessoa","doi":"10.1002/mnfr.202400806","DOIUrl":"https://doi.org/10.1002/mnfr.202400806","url":null,"abstract":"This study explores the effects of a nutraceutical blend with prebiotics, β-glucans, essential minerals, and silymarin on gut microbiota, inflammation, and sleep quality in obesity through microbiota reshaping and metabolic improvements over 90 days. A double-blind, randomized trial was conducted on 77 participants divided into two groups receiving either a standard nutraceutical blend (NSupple) or a silymarin-enriched blend (NSupple_<i>Silybum</i>). Fecal and plasma samples were collected at baseline and post-supplementation for gut microbiota, metabolic, and inflammatory marker analysis. The results showed a reduction in body weight, waist-to-height ratio, total cholesterol, and fractions in the NSupple_<i>Silybum</i> group. There was a dysbiosis recovery shown by the increase in beneficial gut bacteria, such as Lentisphaerae phylum, <i>Lactobacillus</i> and <i>Faecalibacterium</i> genera, and <i>Faecalibacterium prausnitzii</i> in the NSupple group, with a concurrent reduction in <i>Adlercreutzia</i> and <i>Sutterella</i> in the NSupple_<i>Silybum</i> group. Both groups demonstrated improved inflammatory profiles by the reduced TNF-α/IL-10 ratio, reduced cortisol levels, and reduced Firmicutes/Bacteroides ratio. Additionally, improvements in sleep quality were associated with reductions in pro-inflammatory cytokines and improved microbiota composition. The nutraceutical blend reshaped gut microbiota, enhanced anti-inflammatory species, and improved metabolic and sleep parameters, highlighting its potential as a nutritional strategy for managing obesity and reducing inflammation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"22 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruditapes philippinarum Polysaccharide Alleviates Hyperglycemia by Modulating Gut Microbiota in a Mouse Model of Type 2 Diabetes Mellitus","authors":"Zhuo Chen,&nbsp;Xiaodong Ge,&nbsp;Yaolin Wang,&nbsp;Jiawei Zhang,&nbsp;Yinzi Sui,&nbsp;Xuemei Yin,&nbsp;Na Wu,&nbsp;Lei Yang,&nbsp;Jianda Xu,&nbsp;Hongcheng Zhou,&nbsp;Qin Wu,&nbsp;Feng Zeng,&nbsp;Liang Liu,&nbsp;Rong Shao,&nbsp;Wei Xu","doi":"10.1002/mnfr.202400996","DOIUrl":"10.1002/mnfr.202400996","url":null,"abstract":"<div>\u0000 \u0000 <p>Type 2 diabetes mellitus (T2DM), a widespread chronic metabolic disorder, presents a global challenge. Metformin hydrochloride, although widely prescribed, is associated with notable side effects. This study aims to explore safer, more effective alternatives by assessing the impact of <i>Ruditapes philippinarum</i> polysaccharides (RPPs) on glycemic control and modulation of microbiota in T2DM mice. A T2DM mouse model was established through a high-sucrose/high-fat diet and intraperitioneal streptozotocin injection. Glycometabolism indicators, histopathological features, and gut microbiota composition in caecum samples were assessed. Following 4 weeks of RPPs intervention, fasting blood glucose (FBG), glycated serum protein (GSP), area under the curve (AUC) of oral glucose tolerance test (OGTT), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) levels were reduced in T2DM mice, while AKT-1 and GLUT-2 transcription levels were significant increased. Short-chain fatty acids (SCFAs) concentrations notably increased in the RPP-L group compared to the Model group, with improvements also observed in medium-chain fatty acids (MCFAs) and secondary bile acids (SBAs). Regarding gut microbiota, the Firmicutes-to-Bacteroidetes (F/B) ratio in RPP-L was substantially lower than in the Model group. At the genus level, beneficial bacteria, such as <i>Akkermansia</i>, <i>Alloprevotella</i>, <i>Tidjanibacter</i>, and <i>Faecalibaculum</i> demonstrated increased abundance. Correlation analysis identified <i>Muribaculum</i>, <i>Paramuribaculum</i>, <i>Lacrimispora</i>, and <i>Turicibacter</i> as microbial taxa associated with T2DM progression. RPPs significantly alleviated hyperglycemic symptoms in T2DM mice while enhancing the presence of beneficial gut bacteria, leading to a marked improvement in intestinal microbiota composition. This research offers foundational insights for the potential use of <i>R. philippinarum</i> in biomedical and nutraceutical applications.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"69 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}