Molecular Nutrition & Food Research最新文献_第5页

Phenolic Compounds and Bacteriocins: Mechanisms, Interactions, and Applications in Food Preservation and Safety 酚类化合物和细菌素：机制、相互作用及其在食品保存和安全中的应用

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70257

Svetoslav Dimitrov Todorov, Beatriz Marinho de Almeida, Emília Maria França Lima, João Paulo Fabi, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto

引用次数: 0

Bifidobacterium animalis subsp. Lactis BL-99 Improves Maternal and Fetal Immune Responses and Pregnancy Outcomes in Pregnant Antibiotics-Treated Mice. 动物双歧杆菌亚种。Lactis BL-99改善妊娠抗生素治疗小鼠的母胎免疫反应和妊娠结局

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70220

Marijke M Faas,Lieske Wekema,Carolien A van Loo-Bouwman,Gisela A Weiss,Wei-Lian Hung,Bart J de Haan,Alexandra M Smink

{"title":"Bifidobacterium animalis subsp. Lactis BL-99 Improves Maternal and Fetal Immune Responses and Pregnancy Outcomes in Pregnant Antibiotics-Treated Mice.","authors":"Marijke M Faas,Lieske Wekema,Carolien A van Loo-Bouwman,Gisela A Weiss,Wei-Lian Hung,Bart J de Haan,Alexandra M Smink","doi":"10.1002/mnfr.70220","DOIUrl":"https://doi.org/10.1002/mnfr.70220","url":null,"abstract":"The maternal gut microbiome is involved in adapting immune responses to the presence of the semiallogeneic foetus. We have previously shown that antibiotics-induced gut dysbiosis, alterations in the maternal immune response and decreased foetal and placental weight. Here, we tested whether Bifidobacterium animalis subsp. lactis BL-99 (BL-99) could improve antibiotics-induced gut dysbiosis, maternal immune responses and foetal and placental weight. To do so, pregnant mice received antibiotics in their drinking water (day 9-16) and BL-99 via oral gavage (day 9-18). After sacrifice (day 18) immune responses were measured using flowcytometry. BL-99 increased placental weight in antibiotics-treated pregnant mice. BL-99 did not significantly change the maternal microbiome, but improved maternal immune responses by decreasing splenic Th1 cells and Treg cells, and increasing FoxP3/RoRγT double-positive cells in the Peyer's patches to levels observed in control pregnant mice. BL-99 also improved monocyte subsets and activation status. Additionally, BL-99 changed foetal monocyte subsets and activational status and increased foetal splenic Th cells. We thus showed that the effect of antibiotics treatment on immune cells and placental weight was mitigated by supplementation of BL-99. We suggest that pregnancy complications associated with a disturbed microbiome and immune responses, such as preeclampsia or obese pregnancies, could benefit from BL-99 supplementation. This should be tested in future studies.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"63 1","pages":"e70220"},"PeriodicalIF":5.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism. 工业化饮食模式与FTO RS9939609基因多态性儿童心脏代谢危险因素的关系

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70254

Bhreendda' Hary Dy Luar Prates Kiepper,Francilene Maria Azevedo,Aline Carare Candido,Mariane Alves Silva,Juliana Farias de Novaes,Cristina Maria Mendes Resende,Danielle Fernandes Durso,Jacqueline Isaura Alvarez-Leite,Gustavo Velasquez-Melendez,Sylvia do Carmo Castro Franceschini,Eliana Carla Gomes de Souza,Sarah Aparecida Vieira Ribeiro

{"title":"Association Between Industrialized Dietary Pattern and Cardiometabolic Risk Factors in Children With FTO RS9939609 Gene Polymorphism.","authors":"Bhreendda' Hary Dy Luar Prates Kiepper,Francilene Maria Azevedo,Aline Carare Candido,Mariane Alves Silva,Juliana Farias de Novaes,Cristina Maria Mendes Resende,Danielle Fernandes Durso,Jacqueline Isaura Alvarez-Leite,Gustavo Velasquez-Melendez,Sylvia do Carmo Castro Franceschini,Eliana Carla Gomes de Souza,Sarah Aparecida Vieira Ribeiro","doi":"10.1002/mnfr.70254","DOIUrl":"https://doi.org/10.1002/mnfr.70254","url":null,"abstract":"Dietary patterns may increase cardiometabolic risk, especially in genetically predisposed individuals. Thus, the present study evaluated the association between dietary patterns and cardiometabolic risk factors in children with fat mass and obesity associated (FTO) gene polymorphism. A cross-sectional survey of 258 children aged 4-7 years. Body composition was determined with dual-energy x-ray absorptiometry (DEXA). Biochemical samples and blood pressure were analyzed. Genotyping of rs9939609 was performed using oral swab samples and the TaqMan SNP test. Multiple linear regression stratified by FTO gene categories analyzed the association between dietary patterns and cardiometabolic risk factors. The prevalence of polymorphism was 20.2%. Five dietary patterns were identified: \"Traditional\", \"Industrialized\", \"Milk and chocolate milk\", \"Snack\", and \"Natural\". Associations were found between the \"Industrialized\" dietary pattern and both the triglyceride-glucose (TyG) index (β = 0.06; 95% confidence interval [CI]: 0.01-0.11) and triglycerides (β = 7.47; 95% CI: 0.73-14.21) in children with polymorphism. Additionally, \"Milk and Chocolate Milk\" pattern was associated with the TyG index (β = 0.03; 95% CI: 0.00-0.07) in children with a risk allele. For children with FTO gene polymorphism, adherence to the \"Industrialized\" dietary pattern was associated with cardiometabolic risk, highlighting the need for nutritional strategies to prevent.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"42 1","pages":"e70254"},"PeriodicalIF":5.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of FISH-FLOW as a Method for the Identification and Quantification of Bacterial Populations 使用FISH-FLOW作为鉴定和定量细菌种群的方法

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70256

Jorge Enrique Vazquez Bucheli, Yuri Lee, Bobae Kim, Nuno F. Azevedo, Andreia S. Azevedo, Svetoslav Dimitrov Todorov, Yosep Ji, Hyeji Kang, Wilhelm H. Holzapfel

引用次数: 0

Issue Information: Mol. Nutr. Food Res. 17'25 发布信息：Mol. Nutr。Food Res. 17'25

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70212

引用次数: 0

Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant-Induced Toxicities: A Systematic Review of Animal Studies. 益生元和益生菌对环境污染物毒性的保护作用：动物研究的系统综述。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-04 DOI: 10.1002/mnfr.70175

Meysam Zarezadeh,Ahmad Saedisomeolia,Mahsa Mahmoudinezhad,Michele M Iskandar,Fang Lu,Stan Kubow

{"title":"Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant-Induced Toxicities: A Systematic Review of Animal Studies.","authors":"Meysam Zarezadeh,Ahmad Saedisomeolia,Mahsa Mahmoudinezhad,Michele M Iskandar,Fang Lu,Stan Kubow","doi":"10.1002/mnfr.70175","DOIUrl":"https://doi.org/10.1002/mnfr.70175","url":null,"abstract":"Environmental pollutants, including heavy metals, organic pollutants, and mycotoxins, cause various adverse health effects linked to inflammation and oxidative stress. These toxicities disrupt gut microbiota composition and function, which prebiotics and probiotics may counteract. This study systematically reviewed the effects of prebiotics, probiotics, synbiotics, and commensal gut microbiota on pollutant-induced toxicities in animal models. A literature search was conducted using Scopus, PubMed, Embase, Web of Science, and Google Scholar databases up to January 2025, following PRISMA guidelines. Study quality was assessed using the SYRCLE risk of bias tool, and reliability was evaluated with the ToxRTool. Fifty-four studies investigating prebiotics, probiotics, synbiotics, or commensal microbiota in rats, mice, or zebrafish were included. While 98% of studies were considered reliable, only 18% were rated as good quality due to biases in selection, performance, and detection. Probiotics, prebiotics, synbiotics, and gut microbiota reduced heavy metal absorption and increased fecal excretion. They also improved gut barrier integrity and reduced intestinal permeability in animals exposed to heavy metals. Additionally, probiotics and prebiotics enhanced antioxidant activity and triggered anti-inflammatory responses in animals exposed to heavy metals, mycotoxins, and organic pollutants. Overall, this review supports the role of microbiota, probiotics, prebiotics, and synbiotics in mitigating pollutant-induced toxicities, though future studies should address common bias issues.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"162 1","pages":"e70175"},"PeriodicalIF":5.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Gene Expression in Human Fibroblasts by Punicalagin and Ellagic Acid: An In Vitro Study. 槟榔苷和鞣花酸对人成纤维细胞基因表达调控的体外研究。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70237

Rebeca Illescas-Montes, Anabel González-Acedo, Lucía Melguizo-Rodríguez, Enrique García-Recio, Concepción Ruiz, Olga García-Martínez, Javier Ramos-Torrecillas

{"title":"Modulation of Gene Expression in Human Fibroblasts by Punicalagin and Ellagic Acid: An In Vitro Study.","authors":"Rebeca Illescas-Montes, Anabel González-Acedo, Lucía Melguizo-Rodríguez, Enrique García-Recio, Concepción Ruiz, Olga García-Martínez, Javier Ramos-Torrecillas","doi":"10.1002/mnfr.70237","DOIUrl":"https://doi.org/10.1002/mnfr.70237","url":null,"abstract":"The effects of the phenolic compounds punicalagin and ellagic acid, derived from pomegranate, were analyzed on the gene expression of cultured human fibroblasts. The focus was placed on genes associated with growth factors, differentiation markers, and extracellular matrix (ECM) components, all of which play a crucial role in effective wound healing. The human dermal fibroblast cell line CCD-1064Sk was used, and the bioactive compounds punicalagin and ellagic acid were administered to cultured fibroblasts at concentrations of 10-6 and 10-7 M, respectively. Gene expression was assessed at 24 h using real-time polymerase chain reaction (qRT-PCR). Treatments with punicalagin and ellagic acid dose-dependently increased the expression of platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF), collagen 1 (COL1), collagen 3 (COL3), matrix metalloproteinase-2 (MMP2), α-actin, and fibronectin genes. Both compounds modulate the expression of genes related to the synthesis of growth factors, differentiation, and ECM components in human fibroblasts. These findings suggest the potential of these phenolic compounds to develop therapies that improve wound healing. Further studies are needed to better understand the mechanisms of cellular activation.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70237"},"PeriodicalIF":4.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oat Avenanthramide‐C Alleviates DSS‐Induced Colitis Through Regulating Intestinal Immune Activity and Gut Microbiota in Mice 燕麦Avenanthramide - C通过调节小鼠肠道免疫活性和肠道微生物群减轻DSS诱导的结肠炎

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70250

Gaoqi Ye, Genying Li, Ziyuan Wang, Zongwei Wang, Jing Wang, Jie Liu

{"title":"Oat Avenanthramide‐C Alleviates DSS‐Induced Colitis Through Regulating Intestinal Immune Activity and Gut Microbiota in Mice","authors":"Gaoqi Ye, Genying Li, Ziyuan Wang, Zongwei Wang, Jing Wang, Jie Liu","doi":"10.1002/mnfr.70250","DOIUrl":"https://doi.org/10.1002/mnfr.70250","url":null,"abstract":"Oat avenanthramide‐C (AVN‐C) exhibits notable anti‐inflammatory and antioxidant properties, while its potential effects on inflammatory bowel disease (IBD) remain unclear. This study aimed to investigate the impact of AVN‐C on dextran sulfate sodium (DSS)‐induced colitis and explore the underlying mechanisms. Male C57BL/6J mice were treated with AVN‐C (5 and 10 mg/kg BW) for 1 week prior to receiving 2.5% DSS in drinking water for 7 days to induce colitis. AVN‐C treatment continued during the DSS period. The results showed that AVN‐C ameliorated DSS‐induced colitis symptoms and intestinal barrier dysfunction. AVN‐C treatment also reduced neutrophil infiltration and prevented neutrophil extracellular traps (NETs) formation. Moreover, AVN‐C elevated the relative abundance of Firmicutes and Akkermansia, while reducing Proteobacteria and Escherichia‐Shigella, thereby shifting the gut microbial composition toward a more favorable state associated with reduced inflammation. Meanwhile, AVN‐C consumption significantly enhanced intestinal immune activity and maintained gut microbiota balance by modulating primary bile acid biosynthesis through the FXR‐SHP‐NF‐κB signaling pathway. Collectively, AVN‐C exhibited a protective effect against DSS‐induced colitis by modulating neutrophil function, gut microbiota, and bile acid metabolism. These findings highlight the potential of oat AVN‐C as a therapeutic strategy for IBD, offering valuable insights into gastrointestinal health.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"30 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytosterols and Phospholipids Synergistically Improve Lipid Metabolism and Oxidative Stress: Evidence From Animal Model and Human Randomized Controlled Trials. 植物甾醇和磷脂协同改善脂质代谢和氧化应激：来自动物模型和人类随机对照试验的证据。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70248

Yusi Gao, Da Pan, Jiayue Xia, Hui Xia, Shaokang Wang, Wang Liao, Ligang Yang, Guiju Sun

{"title":"Phytosterols and Phospholipids Synergistically Improve Lipid Metabolism and Oxidative Stress: Evidence From Animal Model and Human Randomized Controlled Trials.","authors":"Yusi Gao, Da Pan, Jiayue Xia, Hui Xia, Shaokang Wang, Wang Liao, Ligang Yang, Guiju Sun","doi":"10.1002/mnfr.70248","DOIUrl":"https://doi.org/10.1002/mnfr.70248","url":null,"abstract":"This study aimed to evaluate the effects of phytosterols (PSs), alone or in combination with phospholipids (PLs), on dyslipidemia and oxidative stress, using both a high-fat diet-induced rat model and a randomized controlled trial in individuals with borderline hypercholesterolemia. In the animal study, Sprague-Dawley rats were divided into five groups (control, model, PS, PL, and PS+PL) and treated for 8 weeks. The PS+PL combination significantly reduced body weight, liver index, and serum glutathione peroxidase activity, while improving hepatic and adipose morphology. In the human trial, 82 participants were randomized into PS, PS+PL, or placebo groups and treated for 2 months in a triple-blind, parallel-design trial. Both PS and PS+PL groups showed significant reductions in total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, reactive oxygen species, and lipid peroxidation, along with improvements in antioxidant enzyme and lipase activities. The PS+PL group showed additional effects, including reduced apolipoprotein B and lactate dehydrogenase levels, demonstrating superior efficacy compared to PS alone. In conclusion, PSs, particularly when combined with PLs, effectively improve cholesterol profile and oxidative stress parameters. These findings highlight the potential translational benefits of PS+PL as a functional dietary intervention for managing borderline hypercholesterolemia.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70248"},"PeriodicalIF":4.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index 母乳蛋白质组：哺乳期不同阶段的变化及妊娠期糖尿病和体重指数的影响

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-02 DOI: 10.1002/mnfr.70225

Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen

{"title":"Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index","authors":"Timo Seitz, Jenni Viitaharju, Chouaib Benchraka, Johannes Merilahti, Marko Kalliomäki, Lauri Polari, Diana Toivola, Leo Lahti, Otto Kauko, Kirsi Laitinen","doi":"10.1002/mnfr.70225","DOIUrl":"https://doi.org/10.1002/mnfr.70225","url":null,"abstract":"Breast milk proteome comprises hundreds of bioactive proteins supporting infant development. The extent to which maternal metabolic conditions modify the proteome is poorly known. This study investigates proteome evolution from colostrum to mature milk and examines the impacts of maternal gestational diabetes mellitus (GDM) and BMI on the proteome. We analyzed the proteome by data‐independent acquisition (DIA)‐based LC‐MS/MS from colostrum and mature milk samples collected from mothers (n = 47) with varying BMI values and with (n = 11) or without (n = 36) GDM. We identified 3496 proteins, of which 1055 were differentially abundant between colostrum and mature milk. Colostrum was enriched in proteins related to MHC II antigen response, intestinal IgA, adhesion, and glycosylation, while mature milk showed enrichment in lipid biosynthesis, protein translation, and degradation. In mature milk, mothers with both GDM and higher BMI had increased levels of proteins related to HDL formation. Proteins supporting the maturation of the naive gut immune system were prevalent in colostrum, while those prevalent in mature milk reflected the mammary gland's effort in biosynthesis. Both BMI and GDM have measurable effects on the breast milk proteome. The clinical significance of these findings on a child's future health needs to be clarified.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"31 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0