Lei Li,Yanling Jin,Tiangang Li,Bijun Lv,Difen Yuan,Xiaoya Li,Jiali Yuan
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引用次数: 0
Abstract
Fatty liver disease (FLD), encompassing non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD), has become a major global health concern, primarily driven by unhealthy diets and lifestyle changes. Recently, flavonoids, which account for approximately 60% of polyphenolic compounds, have garnered attention for their antioxidant, anti-inflammatory, and immunomodulatory properties in combating metabolic diseases. This review summarizes recent advancements in the therapeutic potential of flavonoid polyphenols for treating FLD, with a focus on their bioactivity and mechanisms of action, interactions with the gut microbiome, and metabolic effects. The review discusses the bioactivity and biomarkers of flavonoids in treating FLD, their similar and differing roles in NAFLD and AFLD, regulation of gut microbiota, and synergistic mechanisms with other polyphenolic compounds. This review provides insights into the potential applications of flavonoids in treating fatty liver disease and suggests future research directions.
期刊介绍:
Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines:
Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics.
Immunology: Understanding the interactions of food and the immune system.
Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes.
Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.