Molecular Nutrition & Food Research最新文献_第4页

Mechanisms of Butyrate in Diabetes Through the Metabolism-Immunity Axis and Targeted Therapeutic Strategies 丁酸盐通过代谢-免疫轴作用于糖尿病的机制及靶向治疗策略

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-10 DOI: 10.1002/mnfr.70606

Hong-wei Yu, Jian-long Zhang, Fang-jie Liu, Ying Liu, Wan-neng Yan, Ze Yu

引用次数: 0

Mechanism of Shuangshen Xionglian Granule in Attenuating EndMT in Atherosclerosis via the FGFR1–TGF-β/Smad2 Axis 双参雄连颗粒通过FGFR1-TGF-β/Smad2轴减弱动脉粥样硬化终末mt的机制

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-08 DOI: 10.1002/mnfr.70597

Xiaoshan Cui, Hailang Luo, Ran Zhang, Yuanyuan Chen, Hongzheng Li, Jiaming Gao, Huiyu Zhang, Wei Hao, Zikai Yu, Jianhua Fu, Hao Guo

{"title":"Mechanism of Shuangshen Xionglian Granule in Attenuating EndMT in Atherosclerosis via the FGFR1–TGF-β/Smad2 Axis","authors":"Xiaoshan Cui, Hailang Luo, Ran Zhang, Yuanyuan Chen, Hongzheng Li, Jiaming Gao, Huiyu Zhang, Wei Hao, Zikai Yu, Jianhua Fu, Hao Guo","doi":"10.1002/mnfr.70597","DOIUrl":"10.1002/mnfr.70597","url":null,"abstract":"<div>\u0000 \u0000 <p>Shuangshen Xionglian Granule (SSXL), a multi-herb traditional Chinese medicine used for atherosclerosis (AS), was investigated for its anti-atherosclerotic effects and its role in modulating endothelial-to-mesenchymal transition (EndMT). In high-fat diet–fed ApoE<sup>−/−</sup> mice, SSXL ameliorated dyslipidemia, reduced systemic inflammation, and alleviated aortic plaque burden. An integrated approach combining UPLC–QTOF–MS profiling, network pharmacology, and transcriptomics identified 401 SSXL-responsive disease-associated genes, which were enriched in pathways related to TGF-β, MAPK, cAMP, and extracellular matrix organization. In both aortic tissues from these mice and TGF-β2–stimulated human aortic endothelial cells, SSXL preserved endothelial identity and suppressed EndMT. Mechanistically, SSXL restored FGFR1 phosphorylation while concomitantly downregulating TGF-βRI/TGF-β2 expression and Smad2 phosphorylation. Pharmacological inhibition of FGFR1 with PD173074 partially abrogated these protective effects, indicating that SSXL suppresses EndMT, at least in part, through FGFR1-mediated inhibition of the TGF-β/Smad2 signaling axis. These findings suggest that SSXL ameliorates AS through combined lipid-lowering, anti-inflammatory, and anti-EndMT actions, supporting its potential as a multi-target therapeutic candidate for vascular protection in AS.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148910236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fermentation Time Modulates the Osteoprotective Effects of Milk Kefir in Glucocorticoid-Induced Osteoporotic Rats 发酵时间调节乳开菲尔对糖皮质激素所致骨质疏松大鼠的骨保护作用。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-09-07 DOI: 10.1002/mnfr.70601

Thays Allane Cordeiro Maia, Marco Gabriel Silva Leitão, Everton Cavalcante da Silva, Lorena Vasconcelos Vieira, Sofia Tavares Bessa, Igor Santos da Rocha, Paulo Goberlânio de Barros Silva, Francisca Andrea da Silva Oliveira, Paula Goes, Paola Gyuliane Gonçalves, Deborah Catharine de Assis Leite, Fabio Wildson Gurgel Costa, Lidiany Karla Azevedo Rodrigues, Delane Viana Gondim

{"title":"Fermentation Time Modulates the Osteoprotective Effects of Milk Kefir in Glucocorticoid-Induced Osteoporotic Rats","authors":"Thays Allane Cordeiro Maia, Marco Gabriel Silva Leitão, Everton Cavalcante da Silva, Lorena Vasconcelos Vieira, Sofia Tavares Bessa, Igor Santos da Rocha, Paulo Goberlânio de Barros Silva, Francisca Andrea da Silva Oliveira, Paula Goes, Paola Gyuliane Gonçalves, Deborah Catharine de Assis Leite, Fabio Wildson Gurgel Costa, Lidiany Karla Azevedo Rodrigues, Delane Viana Gondim","doi":"10.1002/mnfr.70601","DOIUrl":"10.1002/mnfr.70601","url":null,"abstract":"<p>Milk kefir has shown osteoprotective potential, but whether fermentation duration influences its effects remains unclear. This study evaluated the influence of fermentation time on milk kefir microbial composition and its effects on mandibular bone in glucocorticoid-induced osteoporotic rats. Milk kefir was fermented for 1, 4, or 7 days (MK1, MK4, MK7). Forty male Wistar rats were assigned to five groups (<i>n</i> = 8): healthy control, glucocorticoid-induced osteoporosis (GIO), and GIO treated with MK1, MK4, or MK7. Osteoporosis was induced by weekly intramuscular dexamethasone (7 mg/kg) for 5 weeks, followed by 12 weeks of daily kefir administration (0.7 mL). Microbial composition was assessed by 16S and 18S rRNA gene amplicon sequencing. <i>Lactobacillus</i> dominated the bacterial community, whereas <i>Saccharomyces</i> predominated among fungi, with no major changes across fermentation times. Prolonged fermentation (MK4 and MK7) significantly increased serum calcium, mandibular cortical thickness, interradicular bone area, collagen maturity, and fracture resistance. These findings indicate that prolonged fermentation enhances the osteoprotective effects of milk kefir, despite relative stability of the dominant microbial taxa, highlighting fermentation duration as an important factor in optimizing milk kefir for preserving mandibular bone under osteoporotic conditions.</p>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13548182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148899987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease 二十二碳六烯酸联合卡托普利治疗可减轻吲哚乙酸所致慢性肾病的心血管损伤

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-31 DOI: 10.1002/mnfr.70593

Santosh Pushpa Ramya Ranjan Nayak, Raghul Murugan, Mariadhas Valan Arasu, Ilavenil Soundharrajan, Bader O. Almutairi, Selvaraj Arokiyaraj, Jesu Arockiaraj

{"title":"Combined Docosahexaenoic Acid and Captopril Treatment Attenuates Indole Acetic Acid Induced Cardiovascular Injury in Chronic Kidney Disease","authors":"Santosh Pushpa Ramya Ranjan Nayak, Raghul Murugan, Mariadhas Valan Arasu, Ilavenil Soundharrajan, Bader O. Almutairi, Selvaraj Arokiyaraj, Jesu Arockiaraj","doi":"10.1002/mnfr.70593","DOIUrl":"10.1002/mnfr.70593","url":null,"abstract":"<div>\u0000 \u0000 <p>Chronic kidney disease (CKD) is associated with the accumulation of protein-bound uremic toxins (PBUTs), which cause cardiovascular dysfunction via oxidative stress, inflammation, and fibrosis. Indole-3-acetic acid (IAA), a uremic toxin generated from the gut microbiota, has been identified as a key modulator of cardiovascular injury in CKD. This study looked at the therapeutic efficacy of a 10% docosahexaenoic acid (DHA) supplemented diet paired with captopril (100 mg/kg) in CKD rats exposed to IAA (50 mg/kg) for 30 days. DHA alone enhanced IAA clearance and lowered systemic levels, while the DHA + captopril combination offered the most cardio-protection. Serum troponin-I, CK-MB, and lactate dehydrogenase (LDH) levels were significantly reduced, while antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) were protected. Gene expression analysis revealed lower levels of heart hypertrophic (ANP, BNP, β-MHC) and fibrotic (Col-I, Col-III) markers, which align with the histological findings of reduced myocardial fibrosis and structural preservation. The co-treatment reduced inflammation by inhibiting the AhR-NF-κB signaling pathway and TNF-α expression. These findings demonstrate that DHA in combination with captopril mitigates IAA-induced cardiovascular damage in CKD and represents a promising adjunct strategy to reduce cardiovascular complications in uremic condition.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Sulfur Compounds and Halitosis: Bridging Food Science, Microbial Metabolism, and Oral Health: A Comprehensive Review 膳食硫化合物与口臭：连接食品科学、微生物代谢和口腔健康：综合综述。

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-31 DOI: 10.1002/mnfr.70526

Reuben Acheampong, Jonathan Obuobisa Otu-Ayeboafo

{"title":"Dietary Sulfur Compounds and Halitosis: Bridging Food Science, Microbial Metabolism, and Oral Health: A Comprehensive Review","authors":"Reuben Acheampong, Jonathan Obuobisa Otu-Ayeboafo","doi":"10.1002/mnfr.70526","DOIUrl":"10.1002/mnfr.70526","url":null,"abstract":"<div>\u0000 \u0000 <p>Intraoral halitosis is predominantly caused by anaerobic microbes within the tongue biofilm that break down sulfur-containing amino acids, especially cysteine and methionine, to volatile sulfur compounds (VSCs). In addition to microbial activity, there is growing evidence to suggest that dietary factors are able to influence VSC formation by affecting substrate availability, redox equilibrium, and oral ecological stability and that some of these effects are due to extraoral metabolic activity. This review integrates food chemistry, microbial ecology, and oral health to explain how dietary exposures can interact with the oral microbiome to trigger and maintain halitosis. We synthesize current evidence on tongue biofilm ecology, key microbial taxa and metabolic pathways, and the modifying roles of salivary flow, periodontal inflammation, and common beverages and condiments. Diagnostic approaches are discussed with a mechanistic viewpoint, which has focused on combined organoleptic, gas specific analysis, tongue biofilm imaging, and selective provocation testing. Comprehensively, halitosis is presented as a diet modifiable, ecology-driven disease, the diagnostics of which should be guided by phenotype, and the intervention based on microbiomes and tailored care plans should be sustainable so that evidence-based functional foods and personalized care plans can be developed.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theabrownin Alleviates Alcoholic Liver Disease in Mice by Improving Gut Microbiota and Tryptophan Metabolism 茶啡肽通过改善肠道菌群和色氨酸代谢减轻小鼠酒精性肝病

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-31 DOI: 10.1002/mnfr.70586

Lingxiao Ye, Zizhen Wang, Sihao Zhu, Xiaoyan Ding, Jianrong Han, Yuanwei Hao, Chengyong He, Yu Jiang, Zonghong Liu, Zhenghong Zuo

{"title":"Theabrownin Alleviates Alcoholic Liver Disease in Mice by Improving Gut Microbiota and Tryptophan Metabolism","authors":"Lingxiao Ye, Zizhen Wang, Sihao Zhu, Xiaoyan Ding, Jianrong Han, Yuanwei Hao, Chengyong He, Yu Jiang, Zonghong Liu, Zhenghong Zuo","doi":"10.1002/mnfr.70586","DOIUrl":"10.1002/mnfr.70586","url":null,"abstract":"<div>\u0000 \u0000 <p>Theabrownin (TB) is a bioactive compound derived from tea. Alcoholic liver disease (ALD), caused by chronic alcohol consumption, leads to progressive liver damage associated with inflammation and steatosis. This study aimed to investigate TB's protective effects against ALD and elucidate its mechanisms. A chronic-binge ethanol feeding model was used to induce ALD in mice. Mice were administered TB alongside ethanol exposure. Liver function markers, oxidative stress parameters, inflammatory cytokines, and apoptosis indicators were evaluated. Intestinal barrier integrity and gut inflammation were assessed, along with the expression of tight junction proteins. 16S rRNA sequencing was performed to analyze gut microbiota composition. TB supplementation significantly alleviated hepatic oxidative stress and inflammation and decreased hepatocellular apoptosis. In the gut, TB mitigated ethanol-induced inflammation and restored barrier function by enhancing tight junction protein expression. Microbiota analysis revealed that TB notably increased the abundance of <i>Akkermansia muciniphila</i>, which was associated with altered tryptophan metabolism and activation of the aryl hydrocarbon receptor (AhR) signaling pathway. These changes contributed to the overall protective effect of TB against alcohol-induced toxicity. TB exhibits nutritionally relevant hepatoprotective effects through its antioxidant properties, enhancement of gut barrier integrity, and modulation of the gut microbiota and metabolite-mediated signaling pathways. These findings support the potential of TB as a dietary intervention for preventing or managing ALD.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-Based α-Linolenic Acid as a Superior Nutraceutical to Modulates Apoptosis, Hypoxic Signaling, and Lipid Metabolic Pathway in Breast Cancer: A Comparative Preclinical Study 基于植物的α -亚麻酸作为一种调节乳腺癌细胞凋亡、缺氧信号和脂质代谢途径的优质营养品：一项临床前比较研究

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-31 DOI: 10.1002/mnfr.70467

Anurag Kumar, Pratibha Verma, Nikam Siddhant Rahul, Gaurav Kaithwas

{"title":"Plant-Based α-Linolenic Acid as a Superior Nutraceutical to Modulates Apoptosis, Hypoxic Signaling, and Lipid Metabolic Pathway in Breast Cancer: A Comparative Preclinical Study","authors":"Anurag Kumar, Pratibha Verma, Nikam Siddhant Rahul, Gaurav Kaithwas","doi":"10.1002/mnfr.70467","DOIUrl":"10.1002/mnfr.70467","url":null,"abstract":"<div>\u0000 \u0000 <p>In this study, we investigated and compared the anticarcinogenic efficacy of plant-derived α-linolenic acid (P-ALA) and marine-derived α-linolenic acid (M-ALA) using MCF-7 breast cancer cell line and mammary gland carcinoma model induced by N-methyl-N-nitrosourea (MNU). In vitro MTT assessment on ER+ MCF-7 cells exhibited significant cell viability with P-ALA (IC<sub>50</sub>5.57 µM) when compared with M-ALA (IC<sub>50</sub>5.91 µM) and tamoxifen (TAM) (IC<sub>50</sub> 9.16 µM). Mitochondrial-mediated apoptosis with apoptotic changes were more evident after P-ALA treatment when scrutinized using DAPI, JC-1, and AO/EtBr staining. The P-ALA (<i>p</i> > 0.001***) and M-ALA (<i>p</i> > 0.001***) reversed the cachexia associated with MNU and positively restored lipid profiles (↓TG, ↓LDL, ↓VLDL, and ↑HDL) (<i>p</i> > 0.001***). ECG and HRV analysis showed that P-ALA-HD effectively restored autonomic functions. Lactate analysis P-ALA-HD significantly reduced lactate accumulation. Immunoblotting indicated upregulation of pro-apoptotic (BAX; BAD and caspase-3 at <i>p</i> > 0.001***) and down-regulation of Bcl-2 (<i>p</i> > 0.001***). P-ALA also inhibited lipogenesis (↓SREBP-1c and FASN↑; <i>p</i> > 0.001***), glucose and lactate transport (GLUT-1↓, MCT-1 ↓, and MCT-4↓ at <i>p</i> > 0.001***), hypoxic signaling (↓HIF-1α <i>p</i> > 0.001*** and ↑PHD2 <i>p</i> > 0.001***), and intrinsic mitochondrial apoptotic marker (VDAC-1↓<i>p</i> > 0.001***). P-ALA demonstrated anticancer, lipid-modulating, and cardioprotective that underscore the potential of P-ALA as efficacious and sustainable therapeutic approach for management of breast cancer.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Chicken Protein Hydrolysate in Complementary Baby Food on Protein Quality, Antioxidant Status, and Gut Microbiota in Wistar Rats 婴儿补充食品中鸡蛋白水解物对Wistar大鼠蛋白质品质、抗氧化状态和肠道微生物群的影响

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-27 DOI: 10.1002/mnfr.70537

Neelu Suresh Babu, Mamatha S. Shivaramu, Muthukumar Serva Peddha, Tanaji G. Kudre

{"title":"Impact of Chicken Protein Hydrolysate in Complementary Baby Food on Protein Quality, Antioxidant Status, and Gut Microbiota in Wistar Rats","authors":"Neelu Suresh Babu, Mamatha S. Shivaramu, Muthukumar Serva Peddha, Tanaji G. Kudre","doi":"10.1002/mnfr.70537","DOIUrl":"https://doi.org/10.1002/mnfr.70537","url":null,"abstract":"<div>\u0000 \u0000 <p>This study investigates functional advantages of chicken meat protein hydrolysate (CMPH) as novel protein source for complementary baby food (CBF), focusing on its enhanced bioavailability, bioactivity, and gut-modulating potential. CMPH was produced via <i>Pediococcus pentosaceus</i> fermentation using 45% chicken (<i>Gallus gallus</i> domesticus) meat with 2% dextrose for 48 h. CMPH exhibited strong antioxidant activity (FRAP:27.98 µM TE/mg; DPPH:31.43µMTE/mg; ABTS:24.01µMTE/mg; Fe<sup>2</sup><sup>+</sup>chelation:21.13µMEDTA/mg), indicating its potential to mitigate oxidative stress. CBF formulations were developed using CMPH as sole (CBF-100) or partial (CBF-70:70%CMPH+15%soy+15%milk protein) protein substitute and evaluated in weanling Wistar rats, alongside basal diet (BD:nil protein), standard diet (SD), and commercial CBF. CMPH incorporation significantly improved protein quality indices, with CBF-100 achieving the highest net protein utilization (88.27%), while CBF-70 demonstrated superior growth performance (FCR:2.82; FER:0.35, and PER:2.35), likely due to bioactive peptides enhancing amino acid absorption. All parameters, including hematological, biochemical, and histopathological analyses, remained within normal limits. However, CBF-70 rat group showed significantly higher hemoglobin (15.7 g/dL) and liver antioxidant enzyme activities superoxide dismutase:42.95U/mg; catalase:18.17U/mg (<i>p</i><0.05). Notably, CBF-70 enriched beneficial taxa such as <i>Duncaniella</i> spp. and Muribaculaceae, associated with short-chain fatty acid production and favorable gut-microbiota composition. Overall, CBF-70 being most effective, confirming CMPH as safe and bio-functional protein for advanced complementary nutrition.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Intervention With Lutein, Docosahexaenoic Acid, and Choline During Early Development Improves Recognition Memory in Young Adult Females in an Experimental Model 在实验模型中，叶黄素、二十二碳六烯酸和胆碱在发育早期的饮食干预可以改善年轻成年女性的识别记忆

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-27 DOI: 10.1002/mnfr.70589

Leon Saschin, Gregor Fink, Maria Wohlfarth, Jonas Hauser, Jian Yan, Dirk Wiedermann, Mathias Hoehn, Jochen Wilhelm, Lea Quell, Elisabeth Sous, Jenny Voggel, Jörg Dötsch, Eva Nüsken, Kai-Dietrich Nüsken

{"title":"Dietary Intervention With Lutein, Docosahexaenoic Acid, and Choline During Early Development Improves Recognition Memory in Young Adult Females in an Experimental Model","authors":"Leon Saschin, Gregor Fink, Maria Wohlfarth, Jonas Hauser, Jian Yan, Dirk Wiedermann, Mathias Hoehn, Jochen Wilhelm, Lea Quell, Elisabeth Sous, Jenny Voggel, Jörg Dötsch, Eva Nüsken, Kai-Dietrich Nüsken","doi":"10.1002/mnfr.70589","DOIUrl":"https://doi.org/10.1002/mnfr.70589","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The perinatal period and adolescence are critical for brain development, with nutrition being a crucial factor. Dietary intake of lutein, docosahexaenoic acid (DHA), and choline is positively associated with early neurodevelopment and cognitive function, but interactions remain unclear. This study systematically evaluates lutein, DHA, and choline to elucidate their specific and combined effects on neurodevelopment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <p>To ensure fully controllable conditions, we performed nutritional interventions on a rat model during a critical developmental phase (days 14–56 after birth). After completion of the intervention, no relevant alterations in the open field test or the elevated zero maze were detected. However, both the combination of lutein, DHA, and choline and lutein monotherapy led to an increase in the recognition index for new objects in female rats. No relevant effects on blood and metabolic parameters were observed in any group. In vivo MRI analyses ruled out differences in brain morphology. Our results provide evidence that lutein supplementation during brain development has positive effects on recognition memory in female rats, underscoring the need for sex-specific research on nutritional strategies. Lutein supplementation, particularly in combination with DHA and choline, to enhance neurological development potential should be investigated in further translational studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mnfr.70589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comparative Study on the Anti-Inflammatory Activity of Kaempferol and Its O-Glycosides in LPS-Induced RAW264.7 Cells 山奈酚及其o -糖苷对lps诱导RAW264.7细胞抗炎活性的比较研究

IF 4.5 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2026-08-27 DOI: 10.1002/mnfr.70567

Jinming Peng, Yue Zeng, Yunqian Luo, Guqi Xu, Zhou Xiao, Xiaoxia Gu, Ziyuan Lin, Qin Wang, Wenhua Yang, Jun Li

{"title":"A Comparative Study on the Anti-Inflammatory Activity of Kaempferol and Its O-Glycosides in LPS-Induced RAW264.7 Cells","authors":"Jinming Peng, Yue Zeng, Yunqian Luo, Guqi Xu, Zhou Xiao, Xiaoxia Gu, Ziyuan Lin, Qin Wang, Wenhua Yang, Jun Li","doi":"10.1002/mnfr.70567","DOIUrl":"https://doi.org/10.1002/mnfr.70567","url":null,"abstract":"<div>\u0000 \u0000 <p>Kaempferol and its <i>O</i>-glycosides are prevalent dietary flavonoids, yet their comparative anti-inflammatory activities and underlying mechanisms remain poorly defined. This study evaluated the effects of kaempferol and three <i>O</i>-glycosides (K3G, K3R, K3S) on LPS-induced inflammation in RAW264.7 macrophages. Compared with its <i>O</i>-glycosides, kaempferol exhibited markedly stronger anti-inflammatory activity, shown by greater suppression of inflammatory mediators (NO, PGE<sub>2</sub>, IL-6, TNF-α) and ROS production. Mechanistically, kaempferol inhibited G0/G1 to S phase progression and attenuated MAPK/NF-κB/IκBα signaling, reducing iNOS and COX-2 expressions. Lipidomics analysis revealed that kaempferol restored LPS-disrupted glycerophospholipid homeostasis and modulated key lipid metabolites. Collectively, these findings highlighted the superior in vitro anti-inflammatory activity of kaempferol relative to its <i>O</i>-glycosides, supporting further investigation of its physiological relevance.</p>\u0000 </div>","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"70 17","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0