Molecular Nutrition & Food Research最新文献_第4页

Dietary Consumption of Type 2 Resistant Starch and d-Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High-Fat Diet. 饮食中摄入2型抗性淀粉和d-Fagomine延缓高脂肪饮食雄性大鼠代谢紊乱的进展。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70230

Bernat Miralles-Pérez, Sara Ramos-Romero, María José Charpentier, Vanessa Sánchez-Martos, Àngels Fortuño-Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol-Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu

{"title":"Dietary Consumption of Type 2 Resistant Starch and d-Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High-Fat Diet.","authors":"Bernat Miralles-Pérez, Sara Ramos-Romero, María José Charpentier, Vanessa Sánchez-Martos, Àngels Fortuño-Mar, Julia Ponomarenko, Susana Amézqueta, David Piñol-Piñol, Xiang Zhang, Josep Lluís Torres, Marta Romeu","doi":"10.1002/mnfr.70230","DOIUrl":"https://doi.org/10.1002/mnfr.70230","url":null,"abstract":"High-fat (HF) diets contribute to obesity, insulin resistance, fatty liver, gut microbiota dysbiosis, oxidative stress, and low-grade chronic inflammation. This study evaluated the preventive effects of dietary Type 2 resistant starch (RS2) from high-amylose maize and low-dose d-fagomine (FG) from buckwheat on these metabolic disturbances. Male Wistar-Kyoto rats (9-10 weeks old) were assigned to four diet groups for 10 weeks: standard (STD) diet, HF diet (45% kcal from fat), HF + RS diet (15% RS2), and HF + FG diet (0.1% FG). Body characteristics, metabolic parameters, oxidative stress, gut microbiota, short-chain fatty acids (SCFAs), and eicosanoids were analyzed. Both HF + RS and HF + FG diets reduced perigonadal fat, plasma triacylglycerols, and oxidative stress. HF + RS diet improved glucose tolerance without significantly affecting insulin sensitivity, while HF + FG diet showed a tendency for improvement at later stages. Additionally, HF + RS diet showed greater beneficial effects on body weight and liver steatosis than HF + FG diet, likely due to gut microbiota and SCFA modulation. RS2 exerted stronger metabolic effects than FG under HF diet conditions, suggesting its greater potential in mitigating obesity-related complications. FG effects may require longer exposure to manifest.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70230"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive Modeling of Heart Failure Risk Based on Dietary Antioxidants: A Machine Learning Approach. 基于膳食抗氧化剂的心力衰竭风险预测建模：一种机器学习方法。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70249

Hechao Zhao,Guanguo Shen,Wenjie Zhang,Yangyi Zhang,Xiaochi Wang,Xiaoying Chen,Yali Chen,Linyi Ye,Jingtao Liu,Jing Jiang,Yanhua Wang

{"title":"Predictive Modeling of Heart Failure Risk Based on Dietary Antioxidants: A Machine Learning Approach.","authors":"Hechao Zhao,Guanguo Shen,Wenjie Zhang,Yangyi Zhang,Xiaochi Wang,Xiaoying Chen,Yali Chen,Linyi Ye,Jingtao Liu,Jing Jiang,Yanhua Wang","doi":"10.1002/mnfr.70249","DOIUrl":"https://doi.org/10.1002/mnfr.70249","url":null,"abstract":"This study investigates the relationship between dietary antioxidants and heart failure (HF) risk using nationally representative National Health and Nutrition Examination Survey data (2005-2018). It aims to identify key dietary antioxidants and develop a machine-learning-based predictive model for HF. Among 9279 participants (434 HF cases), 44 dietary antioxidant variables were extracted from two 24-h dietary recalls. Variance inflation factor filtering, SMOTE balancing, and Boruta selection were applied. Six machine learning models-random forest, LightGBM, K-nearest neighbors (KNN), Naive Bayes, support vector machine (SVM), and Xtreme Gradient Boosting (XGBoost)-were trained with and without demographic/lifestyle covariates. WQS and Qg-comp regressions quantified joint antioxidant effects. XGBoost achieved the highest accuracy (0.965 adjusted, 0.963 unadjusted), F1 score (0.971), and PR-AUC (0.993). WQS showed a 20% lower HF odds per quartile increase in overall antioxidant intake (odds ratio [OR] = 0.80, 95% CI: 0.68-0.93). SHAP analysis of the XGBoost model ranked theobromine, lycopene, caffeine, calcium, vitamin B12, vitamin C, and vitamin B1 as top contributors. Higher intake of specific dietary antioxidants-particularly vitamin B6, folate, and lycopene-is significantly associated with reduced HF risk. The XGBoost model provides a robust, interpretable tool for individual-level HF prediction based on dietary antioxidant profiles, supporting evidence-based dietary strategies for HF prevention.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":"e70249"},"PeriodicalIF":5.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Administration of Epigallocatechin Gallate Prevents Air Pollution-Induced Acute Lung Injury in Mice Via the Induction of Antioxidants. 表没食子儿茶素没食子酸酯通过诱导抗氧化剂预防空气污染引起的小鼠急性肺损伤。

IF 4.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-09 DOI: 10.1002/mnfr.70259

Yui Uehara, Hitomi Mito, Ayano Shikata, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Kenta Aso, Masahiro Kawahara, Tomonori Unno, Ken-Ichiro Tanaka

{"title":"Oral Administration of Epigallocatechin Gallate Prevents Air Pollution-Induced Acute Lung Injury in Mice Via the Induction of Antioxidants.","authors":"Yui Uehara, Hitomi Mito, Ayano Shikata, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Kenta Aso, Masahiro Kawahara, Tomonori Unno, Ken-Ichiro Tanaka","doi":"10.1002/mnfr.70259","DOIUrl":"https://doi.org/10.1002/mnfr.70259","url":null,"abstract":"Health hazards caused by air pollutants are increasing worldwide (SDGs 3.9), but no established prevention methods exist. Recently, we showed that intraperitoneal administration of epigallocatechin gallate (EGCG) prevents air pollutant-induced acute lung injury. To establish EGCG ingestion as a preventive method, the efficacy of oral EGCG administration needs to be analyzed, as it is easier than that of intraperitoneal administration. Therefore, we analyzed the effects of oral EGCG administration and ad libitum consumption of an EGCG-containing diet in mice. The combination of 0.2% EGCG-containing diet and oral EGCG administration (200 mg/kg) significantly inhibited the urban aerosol (UA)-induced acute lung injury, although each treatment alone was ineffective. Specifically, compared with the UA group, the combination group showed 37.3% decrease in total cell count, 30.5% decrease in neutrophil count, 52.6% decrease in protein level, and 39.6% decrease in dsDNA level in the bronchoalveolar lavage fluid. This combination also significantly inhibited air pollutant-induced increases in proinflammatory cytokine and chemokine expression (e.g., tumor necrosis factor-α) and ROS production in mouse lungs. Moreover, this combination increased the expression of antioxidant factors, such as nuclear factor E2-related factor 2, in whole blood. Thus, this EGCG-based intervention combination limits UA-induced acute lung injury by increasing antioxidant expression. SUMMARY: The effects of a combination of EGCG-based interventions were analyzed. The combination prevented air pollutant-induced lung inflammatory responses. The combination suppressed air pollutant-induced ROS production in the lungs. The combination increased the expression of various antioxidants in whole blood.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":" ","pages":"e70259"},"PeriodicalIF":4.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable Solutions From Silkworms: Antheraea assamensis Helfer Oil Regulates Oxidative Stress, Lipid Metabolism, and Liver Health-Navigating Future Food Challenges. 蚕的可持续解决方案：柞蚕蚕丝油调节氧化应激、脂质代谢和肝脏健康——未来食物挑战的导航。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-08 DOI: 10.1002/mnfr.70232

Richa Dhakal,Anjum Dihingia,Prachurjya Dutta,Jatin Kalita

{"title":"Sustainable Solutions From Silkworms: Antheraea assamensis Helfer Oil Regulates Oxidative Stress, Lipid Metabolism, and Liver Health-Navigating Future Food Challenges.","authors":"Richa Dhakal,Anjum Dihingia,Prachurjya Dutta,Jatin Kalita","doi":"10.1002/mnfr.70232","DOIUrl":"https://doi.org/10.1002/mnfr.70232","url":null,"abstract":"Silkworms are emerging as a sustainable food source to address global food security, with their proteins recognized for nutritional and medicinal benefits. However, the impact of silkworm oil on immunological and pharmacological effects remains unexplored. This study explores the effects of the muga (Antheraea assamensis Helfer) silkworm pupal oil fraction (MP) on palmitic acid (PA) induced hepatic steatosis, inflammation, and oxidative stress. The findings revealed that MP supplementation significantly reduced lipid accumulation in PA treated CC1 hepatocytes as demonstrated by Oil red O and Nile red staining. Mechanistic investigations showed that MP modified the protein expressions and mRNA levels of genes involved in lipogenesis and cholesterol homeostasis, while upregulating genes responsible for β-oxidation. Additionally, MP treatment enhanced the phosphorylation of AMPK, a crucial metabolic energy sensor, and reduced the phosphorylation of NF-κB, which is associated with inflammation. The study concludes that the muga silkworm pupal oil fraction (MP) has the potential to serve as an effective nutraceutical, contributing to the development of therapeutic strategies for managing dysregulated lipid metabolism and associated inflammatory conditions.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"51 1","pages":"e70232"},"PeriodicalIF":5.2,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wild Versus Cultivated: Assessing the Nutritional Superiority of a Diploid Potato Species Solanum okadae for Future Food Security. 野生与栽培：对未来粮食安全的二倍体马铃薯品种冈田茄的营养优势评估。

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-07 DOI: 10.1002/mnfr.70236

Amar Hundare

{"title":"Wild Versus Cultivated: Assessing the Nutritional Superiority of a Diploid Potato Species Solanum okadae for Future Food Security.","authors":"Amar Hundare","doi":"10.1002/mnfr.70236","DOIUrl":"https://doi.org/10.1002/mnfr.70236","url":null,"abstract":"Potatoes are a global staple, yet their nutritional potential is underutilized. This study evaluates the biochemical and nutritional composition of Solanum okadae (S. okadae), a wild diploid potato species, compared to the cultivated S. tuberosum \"Celandine,\" assessing its potential for dietary improvement and biofortification. Standard biochemical assays were used to analyze proximate composition, vitamins, mineral content via ICP-MS, and amino acids via HPLC/FD. S. okadae exhibited higher carbohydrate (18.47 g/100 g) and protein (2.1 g/100 g) content than S. tuberosum. Mineral profiling revealed significantly higher potassium (30.10 g/kg), calcium (2.92 g/kg), iron (28.42 ppm), and zinc (21.31 ppm) levels in S. okadae. It also contained more vitamin C (10.69 mg/100 g) and an uncommon presence of vitamin B12 (0.28 mg/100 g). Amino acid profiling showed higher leucine (5.62 g/kg) and lysine (5.46 g/kg) levels, indicating S. okadae's protein quality. Its lower moisture content (75.9 g/100 g) suggests better postharvest stability, while minimal trans fat (< 0.02 g/100 g) supports cardiovascular health. S. okadae is a nutrient-dense alternative to cultivated potatoes, providing higher essential macronutrients, vitamins, and minerals. It holds potential for breeding programs and biofortification. Further research should explore its large-scale cultivation and adaptability to enhance global food security.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"68 1","pages":"e70236"},"PeriodicalIF":5.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Dietary Biotin Intake and Dementia Risk, Including Alzheimer's Disease: A Prospective Study of 122 959 UK Biobank Participants. 膳食生物素摄入与痴呆风险之间的关系，包括阿尔茨海默病：一项对122959名英国生物银行参与者的前瞻性研究

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-07 DOI: 10.1002/mnfr.70252

Yan Kong,Jiping Zhong,Tong Wang,Dongfeng Zhang

{"title":"Association Between Dietary Biotin Intake and Dementia Risk, Including Alzheimer's Disease: A Prospective Study of 122 959 UK Biobank Participants.","authors":"Yan Kong,Jiping Zhong,Tong Wang,Dongfeng Zhang","doi":"10.1002/mnfr.70252","DOIUrl":"https://doi.org/10.1002/mnfr.70252","url":null,"abstract":"The relationship between dietary biotin intake and cognitive function remains unclear. This study explores the association between biotin and dementia, and the mediating role of inflammation indicators. Dietary biotin intake was assessed via the 24-h recall questionnaire. Dementia outcomes were identified through \"algorithmically defined outcomes,\" identified through an algorithm integrating self-reports, hospital admissions, and death certificate records. Participants aged 40-69 with complete biotin and baseline data were included. During a 11.25-year median follow-up, 1256 incident dementia cases occurred among 122 959 participants. Cox proportional hazards models showed that compared to the lowest biotin intake (Q1), biotin reduced the risk of all-cause dementia (HR: 0.75[0.64,0.88] p < 0.001 for Q2; HR: 0.68[0.58,0.81] p < 0.001 for Q3; HR: 0.67[0.56,0.81] p < 0.001 for Q4) and Alzheimer's disease (AD) (HR: 0.74[0.58,0.96] p = 0.026 for Q2; HR: 0.65[0.49,0.85] p = 0.002 for Q3). Restricted cubic splines (RCSs) revealed an \"L-shaped\" nonlinear relationship between biotin and all-cause dementia (p nonlinear < 0.001) and Alzheimer's dementia (p nonlinear = 0.004) and exhibited the saturation effect. Multicategorical mediation analysis suggested that systemic immune-inflammation index (SII), a composite inflammatory marker calculated from platelet, neutrophil, and lymphocyte counts, mediated the association partially. Subgroup and sensitivity analyses confirmed stable results. Higher dietary biotin intake may reduce the risk of dementia.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"2 1","pages":"e70252"},"PeriodicalIF":5.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health 父亲的饮食塑造未来：父亲的营养如何影响胎盘发育和儿童代谢健康

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-06 DOI: 10.1002/mnfr.70261

David A. Skerrett‐Byrne, Anne‐Sophie Pepin, Katharina Laurent, Johannes Beckers, Robert Schneider, Martin Hrabě de Angelis, Raffaele Teperino

{"title":"Dad's Diet Shapes the Future: How Paternal Nutrition Impacts Placental Development and Childhood Metabolic Health","authors":"David A. Skerrett‐Byrne, Anne‐Sophie Pepin, Katharina Laurent, Johannes Beckers, Robert Schneider, Martin Hrabě de Angelis, Raffaele Teperino","doi":"10.1002/mnfr.70261","DOIUrl":"https://doi.org/10.1002/mnfr.70261","url":null,"abstract":"Early‐life programming is a major determinant of lifelong metabolic health, yet current preventive strategies focus almost exclusively on maternal factors. Emerging experimental and preclinical data reveal that a father's diet before conception, particularly high‐fat intake, also shapes offspring physiology. Here, we synthesize the latest evidence on how such diets remodel the sperm epigenome during two discrete windows of vulnerability: (i) testicular spermatogenesis, via DNA methylation and histone modifications, and (ii) post‐testicular epididymal maturation, where small non‐coding RNAs are selectively gained. We examine how these epigenetic signals influence pregnancy, placental development, and ultimately, metabolic trajectories in progeny. To extend published work, we sourced publicly available diet‐induced sperm epigenome datasets and provide new potential connections of these changes to genes governing placental development, vascularization and size using the International Mouse Phenotyping Consortium data. Moreover, we further interrogate these overlaps with intricate in‐silico analyses to examine their potential consequences. To foster meaningful interactions with these findings, we have developed a web application for ease (ShinySpermPlacenta). Collectively, these findings support a biparental model of preconception care and position the sperm epigenome as a promising tractable biomarker platform for personalized paternal nutrition counselling aimed at improving fertility and reducing intergenerational metabolic disease risk.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nobiletin Alleviates Npy1r‐Mediated Insulin Secretion Deficiency of Islet β‐Cells via the Clock‐Modulatory Signaling Nobiletin通过时钟调节信号缓解Npy1r介导的胰岛β细胞胰岛素分泌不足

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-06 DOI: 10.1002/mnfr.70208

Qianru Xiang, Xiao Chen, Enhui Tang, Zhi Chen, Zijun Xia, Wenzhen Liao

{"title":"Nobiletin Alleviates Npy1r‐Mediated Insulin Secretion Deficiency of Islet β‐Cells via the Clock‐Modulatory Signaling","authors":"Qianru Xiang, Xiao Chen, Enhui Tang, Zhi Chen, Zijun Xia, Wenzhen Liao","doi":"10.1002/mnfr.70208","DOIUrl":"https://doi.org/10.1002/mnfr.70208","url":null,"abstract":"Current research indicates that insulin secretion deficiency in β‐cells contributes to Type 2 diabetes mellitus (T2DM), which is associated with neuropeptide Y1 receptor (Npy1r) overexpression from neuropeptide Y (NPY) system dysregulation. To date, limited literature has explored nobiletin (NOB) as a circadian modulator for restoring β‐cell function through Npy1r regulation. This study investigates NOB's stimulatory effects on insulin secretion via Npy1r and clock‐modulatory signaling to elucidate its underlying mechanism. The findings demonstrated that NOB ameliorated hyperglycemia and promoted insulin secretion in two distinct mouse models: T2DM induced by a high‐fat diet with low‐dose streptozotocin, and acute hyperglycemia triggered by NPY. Moreover, NOB reduced NPY family peptides in the serum and suppressed Npy1r overexpression in β‐cells. Comprehensive investigations revealed that NOB mitigated Npy1r‐mediated β‐cell dysfunction through activating clock‐modulatory signaling, evidenced by restored Bmal1::Luc bioluminescence rhythmicity in mouse insulinoma6 (MIN6) cells. Molecular docking confirmed a direct NOB‐Npy1r interaction, while mechanistic analyses demonstrated modulation of the retinoic acid‐related orphan receptors (RORs)/Bmal1‐Yes‐associated protein (Yap) pathway via Yap suppression and Bmal1 activation, based on the interventions with palmitic acid, BMS 193885 (Npy1r antagonist), and NPY. Therefore, this study provides evidence that NOB can protect β‐cells from insulin secretion dysfunction by downregulating Npy1r expression and activating the RORs/Bmal1‐Yap pathway.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"24 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences 营养保健品补充和地中海低热量饮食对计算脂肪变性指数和炎症的影响：临床和体外证据

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-06 DOI: 10.1002/mnfr.70207

Mariana Di Lorenzo, Luca Pipicelli, Laura Aurino, Concetta Sozio, Anna Palmiero, Domenico Palmieri, Marta Lombardi, Bruna Guida, Mariarosaria Santillo, Maria Serena Lonardo, Giuliana La Rosa, Simona Damiano

{"title":"Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences","authors":"Mariana Di Lorenzo, Luca Pipicelli, Laura Aurino, Concetta Sozio, Anna Palmiero, Domenico Palmieri, Marta Lombardi, Bruna Guida, Mariarosaria Santillo, Maria Serena Lonardo, Giuliana La Rosa, Simona Damiano","doi":"10.1002/mnfr.70207","DOIUrl":"https://doi.org/10.1002/mnfr.70207","url":null,"abstract":"This study evaluated the effect of a nutraceutical supplementation (NS) and Mediterranean hypocaloric diet (MHD) on hepatic steatosis indices (HSIs), γ‐glutamyl transferase (γGT), and lipid profile in adults with hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). In vitro study on HepG2 cells explored potential molecular mechanisms. A retrospective study was conducted on 45 overweight/obese subjects (19 M) prescribed MHD with/without NS. Anthropometric data, biochemical parameters, HSIs, and γGT were collected at baseline and after 3 months. In vitro, cells were pretreated with single and mixed NS components and then with tumor necrosis factor α (TNFα) or fatty acids (FAs). Antioxidant and antiinflammatory activities were evaluated by fluorescence assays and quantitative polymerase chain reaction or enzyme‐linked immunosorbent assay; antiapoptotic effects by Western blot. After 3 months, all subjects improved anthropometric and biochemical parameters but only the combined MHD and NS treatment significantly reduced insulin resistance, HSIs, low‐density lipoprotein cholesterol, and γGT. In vitro, treatment with mixed NS components decreased TNFα‐/FAs‐induced reactive oxygen species. Combined treatment also modulated the inflammatory response by lowering interleukin‐6 and interleukin‐1β, increasing interleukin‐10 and pro‐caspase 8 expression. These findings suggest that NS, due to its antiinflammatory properties, represents a promising strategy for NAFLD management.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"53 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ellagic Acid Promotes Lipid Reduction in High‐Fat Diet‐Induced Obese Mice by Remodeling the Gut Microbiota and Activating PPAR Pathways and Retinol Metabolism in Adipose Tissue 鞣花酸通过重塑肠道菌群、激活脂肪组织中PPAR通路和Retinol代谢，促进高脂饮食诱导的肥胖小鼠脂质减少

IF 5.2 2区农林科学

Molecular Nutrition & Food Research Pub Date : 2025-09-06 DOI: 10.1002/mnfr.70246

Xin Geng, Qingcui Li, Fan Zhou, Xiaoze Pang, Jin Sun, Ce Qi

{"title":"Ellagic Acid Promotes Lipid Reduction in High‐Fat Diet‐Induced Obese Mice by Remodeling the Gut Microbiota and Activating PPAR Pathways and Retinol Metabolism in Adipose Tissue","authors":"Xin Geng, Qingcui Li, Fan Zhou, Xiaoze Pang, Jin Sun, Ce Qi","doi":"10.1002/mnfr.70246","DOIUrl":"https://doi.org/10.1002/mnfr.70246","url":null,"abstract":"Ellagic acid (EA), a bioactive polyphenol abundant in pomegranate and berries, exhibits potential in metabolic regulation. This study investigates EA's anti‐obesity mechanisms, focusing on its effects on gut microbiota and transcriptional regulation in adipose tissue. After a 9‐week high‐fat diet feeding, mice were divided into groups and treated with low‐dose EA (10 mg/kg/day), high‐dose EA (30 mg/kg/day), or urolithin A (20 mg/kg/day) for 7 weeks, with healthy and obese controls included. In diet‐induced obese mice, a 7‐week EA intervention (10 mg/kg/day) significantly reduced adiposity (−46.96%, p < 0.01) and improved serum lipid profiles. Transcriptome analysis revealed PPARγ upregulation (380.34%, p < 0.001) and retinol metabolism activation (Rdh11, 1.51‐fold) in white adipose tissue. Gut microbiota analysis showed that low‐dose EA inhibited Mailhella massiliensis abundance (73.64%, p < 0.001). It also enhanced nocturnal energy expenditure (56.79%, p < 0.05) and improved antioxidant capacity. In contrast, high‐dose EA and UroA neither activated these pathways nor suppressed harmful bacteria, and physical activity levels remained unchanged.Low‐dose EA ameliorates obesity via PPARγ‐mediated lipid metabolism, retinol metabolism activation, and gut microbiota modulation (M. massiliensis suppression). EA‐rich foods may serve as functional dietary strategies for obesity management.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"30 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0