Nicotinamide Riboside Supplementation Alleviates Heat Stress‐Induced Testicular Damage and Improves Semen Quality in Boars

IF 4.5 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-06-30 DOI:10.1002/mnfr.70162

Wenxue Shen, Xihao Luo, Xianyang Jin, Xiangyuan Ma, Xuemei Jiang, Chao Jin, Bin Feng, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Yan Lin, Yong Zhuo, De Wu, Lun Hua

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引用次数: 0

Abstract

Rising global temperatures and increasing extreme weather events have profound and widespread health impacts, particularly on vulnerable populations and sensitive organs. This study aimed to investigate the impact of HS on testicular NAD+ metabolism and assess the potential of NAD+ precursor supplementation in alleviating heat stress (HS)‐induced reductions in semen quality. This study aimed to investigate the impact of HS on testicular NAD+ metabolism and assess the potential of NAD+ precursor supplementation in alleviating HS‐induced reductions in semen quality. In this study, 24 Rongchang boars were randomly divided into three groups: a control group (CON), HS group, and HS supplementation with nicotinamide riboside group (HS‐NR). After the initial feeding phase, the boars were exposed to either a thermoneutral or HS environment for 2 weeks. In this study, we identified NAD+ deficiency as a hallmark of testicular damage under HS. Supplementation with NR effectively restored testicular NAD+ metabolism. NR supplementation also improved semen quality, reduced spermatogenesis defects, and attenuated oxidative stress and inflammation induced by HS. These findings highlight the potential of NAD+ precursors as a promising nutritional strategy to mitigate the adverse effects of HS on male reproductive health.

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添加烟酰胺核苷可减轻热应激诱导的公猪睾丸损伤和提高精液质量

全球气温上升和极端天气事件增加对健康产生深远而广泛的影响，特别是对弱势群体和敏感器官。本研究旨在研究HS对睾丸NAD+代谢的影响，并评估补充NAD+前体在缓解热应激（HS）诱导的精液质量下降中的潜力。本研究旨在探讨HS对睾丸NAD+代谢的影响，并评估补充NAD+前体在缓解HS诱导的精液质量下降中的潜力。试验选用24头荣昌公猪，随机分为3组：对照组（CON）、HS组和HS添加烟酰胺核苷组（HS‐NR）。初始饲喂阶段结束后，公猪分别暴露在热中性或高温环境中2周。在这项研究中，我们发现NAD+缺乏是HS下睾丸损伤的标志。补充NR可有效恢复睾丸NAD+代谢。补充NR还可以改善精液质量，减少精子发生缺陷，减轻HS诱导的氧化应激和炎症。这些发现强调了NAD+前体作为一种有希望的营养策略来减轻HS对男性生殖健康的不利影响的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.