Photochemical & Photobiological Sciences最新文献_第2页

UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells. uva光诱导的人类核苷酸切除修复缺陷细胞外显子组突变。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1007/s43630-025-00697-9

Nathalia Quintero-Ruiz, Camila Corradi, Natália Cestari Moreno, Tiago Antonio de Souza, Carlos Frederico Martins Menck

{"title":"UVA-light-induced mutagenesis in the exome of human nucleotide excision repair-deficient cells.","authors":"Nathalia Quintero-Ruiz, Camila Corradi, Natália Cestari Moreno, Tiago Antonio de Souza, Carlos Frederico Martins Menck","doi":"10.1007/s43630-025-00697-9","DOIUrl":"10.1007/s43630-025-00697-9","url":null,"abstract":"Skin cancer is associated with genetic mutations caused by sunlight exposure, primarily through ultraviolet (UV) radiation that damages DNA. While UVA is less energetic, it is the predominant solar UV component reaching the Earth's surface. However, the mechanisms of UVA-induced mutagenesis and its role in skin cancer development remain poorly understood. This study employed whole exome sequencing of clones from human XP-C cells, which lack nucleotide excision repair (NER), to characterize somatic mutations induced by UVA exposure. DNA sequence analysis of UVA-irradiated XP-C cells revealed a marked increase in mutation frequency across nearly all types of base substitutions, with particular enrichment in C > T transitions within the CCN and TCN trinucleotide context-potential sites for pyrimidine dimer formation. The C > T mutation primarily occurred at the 3' base of the 5'TC dimer, and an enrichment of CC > TT tandem mutations. We also identified the SBS7b COSMIC mutational signature within irradiated cells, which has been associated with tumors in sun-exposed skin. C > A transversions, often linked to oxidized guanine, were the second most frequently induced mutation, although a specific context for this base substitution was not identified. Moreover, C > T mutations were significantly increased in unirradiated XP-C compared to NER-proficient cells, which may be caused by unrepaired spontaneous DNA damage. Thus, this study indicates that pyrimidine dimers are the primary lesions contributing to UVA-induced mutagenesis in NER-deficient human cells and demonstrates that UVA generates mutational signatures similar to those of UVB irradiation.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"429-449"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIMP3 deficiency accelerates UVB-induced HaCaT cell senescence by regulating ferroptosis. TIMP3缺乏通过调节铁下垂加速uvb诱导的HaCaT细胞衰老。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-21 DOI: 10.1007/s43630-025-00701-2

Yan Teng, Junjia He, Yeyu Shen, Jie Chen, Ye Qian, Youming Huang, Xiaohua Tao, Danfeng Xu, Yibin Fan

{"title":"TIMP3 deficiency accelerates UVB-induced HaCaT cell senescence by regulating ferroptosis.","authors":"Yan Teng, Junjia He, Yeyu Shen, Jie Chen, Ye Qian, Youming Huang, Xiaohua Tao, Danfeng Xu, Yibin Fan","doi":"10.1007/s43630-025-00701-2","DOIUrl":"10.1007/s43630-025-00701-2","url":null,"abstract":"Prolonged exposure to ultraviolet B (UVB) light leads to the accumulation of reactive oxygen species (ROS), a key contributor to skin aging. Previous studies have demonstrated that UVB exposure results in a deficiency in the expression of TIMP3 in keratinocytes. The objective of this study was to investigate the specific role of TIMP3 in keratinocytes. UVB-treated HaCaT cells were utilized to establish a cellular photoaging model. We found that UVB significantly increased levels of ROS, promoted senescence and ferroptosis, and inhibited the expression of TIMP3 in HaCaT. This inhibition was notably alleviated by Fer-1, a ferroptosis inhibitor. In addition, the knockdown of TIMP3 in HaCaT enhanced senescence by inducing the ferroptosis. Mechanistically, UVB exposure also led to a decrease in the expression of KLF4, a transcription factor that regulated TIMP3 expression. Futhermore, UVB-induced reduced expression of KLF4 and TIMP3 in vivo. Our results suggest that deletion of the KLF4/TIMP3 axis promotes HaCaT cell senescence by facilitating the progression of ferroptosis. TIMP3 may serve as an effective therapeutic target for preventing skin photoaging.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"499-509"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How warming impacts the photosynthetic physiology of the bloom-forming cyanobacterium, Microcystis aeruginosa, under UV exposure. 在紫外线照射下，变暖如何影响开花形成的蓝藻，铜绿微囊藻的光合生理。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-24 DOI: 10.1007/s43630-025-00705-y

Menglin Bao, Yingze Yuan, Shasha Zang, Fang Yan, Zhiguang Xu, Hongyan Wu

{"title":"How warming impacts the photosynthetic physiology of the bloom-forming cyanobacterium, Microcystis aeruginosa, under UV exposure.","authors":"Menglin Bao, Yingze Yuan, Shasha Zang, Fang Yan, Zhiguang Xu, Hongyan Wu","doi":"10.1007/s43630-025-00705-y","DOIUrl":"10.1007/s43630-025-00705-y","url":null,"abstract":"Microcystis aeruginosa is a common cyanobacterium leading to algal blooms. Coupled effects of temperature increase and UV radiation increase will affect its photosynthesis performance, which may in turn will affect its proliferation and distribution, and change the environmental health of the water body. In this study, M. aeruginosa FACHB 469 was incubated at 25 °C and 30 °C and subjected to photosynthetically active radiation (PAR) and UV radiation (PAR + UVR) to monitor the relevant physiological responses. Exposure to both PAR and PAR + UVR resulted in a decline in PSII maximum quantum yield of M. aeruginosa, with UVR having more significant inhibitory effect. Meanwhile, UVR significantly increased the PSII photoinactivation rate constant (Kpi) and decreased the PSII repair rate constant (Krec), whereas the warming did not have a significant effect on it, and no significant interaction effect between warming and UVR was observed. Further analysis of the strategies of algal cells to cope with UVR at different temperatures revealed that at 25 °C, algal cells mainly relied on the repair cycle of PSII, and reduced the content of phycocyanin to lower light energy capture, and increased superoxide dismutase (SOD) and catalase (CAT) activities to alleviate the damage of UVR; whereas under warming conditions, algal cells, while relying on PSII repair, mainly photoprotect by strengthening the NPQ mechanism, thus improving their tolerance to UVR. These findings suggest that the differential strategies employed by M. aeruginosa to cope with UVR under varying temperature conditions may influence the resilience of cyanobacterial blooms to environmental stressors in the future.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"519-529"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging role of ferroptosis in ultraviolet radiation-driven skin photoaging: a narrative review. 铁下垂在紫外线辐射驱动的皮肤光老化中的新作用：叙述性回顾。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-10 DOI: 10.1007/s43630-025-00691-1

Yan Teng, Youming Huang, Xiaohua Tao, Yibin Fan, Jianhua You

{"title":"Emerging role of ferroptosis in ultraviolet radiation-driven skin photoaging: a narrative review.","authors":"Yan Teng, Youming Huang, Xiaohua Tao, Yibin Fan, Jianhua You","doi":"10.1007/s43630-025-00691-1","DOIUrl":"10.1007/s43630-025-00691-1","url":null,"abstract":"Photoaging is characterized by chronic inflammation in response to ultraviolet (UV) radiation. UV radiation causes skin cells to produce reactive oxygen species (ROS), which causes oxidative stress and inflammation. ROS can reversibly or irreversibly destroy different cellular compounds, including nucleic acids, proteins, free amino acids, lipids, lipoproteins, carbohydrates, and connective tissue macromolecules. Ferroptosis is a kind of programmed cell death caused by iron dependence and lipid peroxidation and has been recently discovered. Its occurrence is primarily related to iron metabolism, antioxidants, lipid peroxidation, and other processes. In addition, high levels of ROS can trigger oxidative stress, altering the redox balance within cells and thus initiating ferroptosis. Ferroptosis has been implicated in UV-driven skin photoaging. Moreover, UV radiation from sunlight can regulate numerous ferroptosis-linked genes. This review will focus on the function of ferroptosis in UV radiation-damaged skin cells. We hope to draw attention to the significance of ferroptosis regulation in the prevention and treatment of skin photoaging.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"531-542"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic conversion of copper (II) ions to metallic copper (0) on TiO₂ nanoparticles. TiO2纳米颗粒上铜（II）离子光催化转化为金属铜(0)的研究。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-03-01 Epub Date: 2025-03-13 DOI: 10.1007/s43630-025-00702-1

Zhen-Kun He, Jiayin Xu, Qinzhuan Shu, Haobo Li, Zhina Ji, Aimin Liu, Haitao Huang, Zhongning Shi

{"title":"Photocatalytic conversion of copper (II) ions to metallic copper (0) on TiO2 nanoparticles.","authors":"Zhen-Kun He, Jiayin Xu, Qinzhuan Shu, Haobo Li, Zhina Ji, Aimin Liu, Haitao Huang, Zhongning Shi","doi":"10.1007/s43630-025-00702-1","DOIUrl":"10.1007/s43630-025-00702-1","url":null,"abstract":"Under the initiative of the United Nations Sustainable Development Goals (SDGs), utilization of clean energy for metallurgy has emerged as a new trend in recent years. Precious metal ions with low chemical reactivity have been readily photoreduced, while active metal such as copper has been rarely reported. In this work, photocatalytic reduction of Cu(II) ions was investigated utilizing TiO2 nanoparticles as catalyst. By surface charge optimization in different anionic species-based cupric solution, nanoparticle products with Cu2O as out shell and zero-valent Cu as the core have been photocatalytic prepared. The photocatalysis conditions such as catalyst amount, Cu(II) ions concentration, ethanol addition, and illumination wavelength were optimized, good cycling stability was confirmed. Argon etching results and thermogravimetric analysis confirmed the appearance of zero-valent Cu metal in the core of nanoparticle products. Ex situ photoreaction investigation revealed the consumption pathway of oxidative holes and photoreduction mechanism of Cu(II) ions. This research could provide some insights into the photoreduction method of active metals and the photocatalytic removal of heavy metal ions within the realm of environmental protection.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"511-518"},"PeriodicalIF":2.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pt-doped g-C₃N₄ photocatalyst for simultaneous hydrogen production and value-added chemical synthesis under visible light. 可见光下同时产氢和增值化学合成的掺杂pt g-C3N4光催化剂。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-02-01 Epub Date: 2025-02-20 DOI: 10.1007/s43630-025-00683-1

Marwa Moussa, Abdessalem Hamrouni, Nawres Lazaar, Mounir Ferhi, Ichraf Chérif, Hinda Lachheb, Cláudia G Silva, Maria J Sampaio, Joaquim L Faria

{"title":"Pt-doped g-C3N4 photocatalyst for simultaneous hydrogen production and value-added chemical synthesis under visible light.","authors":"Marwa Moussa, Abdessalem Hamrouni, Nawres Lazaar, Mounir Ferhi, Ichraf Chérif, Hinda Lachheb, Cláudia G Silva, Maria J Sampaio, Joaquim L Faria","doi":"10.1007/s43630-025-00683-1","DOIUrl":"10.1007/s43630-025-00683-1","url":null,"abstract":"Metal-free photocatalysts, especially through the use of semi-conductors g-C3N4 (graphitic carbon nitride, CN) have become a prominent topic due to their sustainable advantages and promising effectiveness in hydrogen (H2) production. However, CN material requires specific modifications, since its efficacy under visible light suffers from fast recombination of electron/hole pairs (e‒/h+), slow charge transfer and limited surface area. In this study, we present the synthesis of CN via the thermal treatment of urea and melamine mixture. To enhance its crystallinity and photocatalytic performance, Pt nanoparticles were loaded onto CN by simple incipient wetness impregnation method. The H2 production was investigated through the potential application of aromatic alcohols including anisyl (AA), benzyl (BA), piperonol (PA), and methanol (M) alcohols, as sacrificial reagents. H2 production was achieved using the hybrid Pt-CN system with the added benefit of value-added organic synthesis under visible light exposure. The Pt-CN photocatalyst exhibited varying H2 evolution rates on the alcohol used as sacrificial reagent, with the PA yielding to the highest rate of 503.5 µmol·g-1·h-1. Stability assessments confirmed the robustness of the synthesized Pt-CN photocatalyst across three consecutive visible light driven experiments. Notably, piperonal (P) synthesis occurred along with H2 production under visible light. Comprehensive structural, textural, morphologic, optoelectronic and electrochemical characterizations were performed correlating the Pt-CN's properties with its visible photocatalytic performance.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"247-259"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photophysical and thermodynamic landscape of interaction of a styryl-based dye with DNA duplex: effect of medium ionic strength and live cell imaging. 苯乙烯基染料与DNA双工相互作用的光物理和热力学景观：介质离子强度和活细胞成像的影响。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-02-01 Epub Date: 2025-02-25 DOI: 10.1007/s43630-025-00693-z

Viki Bhakta, Zofa Shireen, SanjitDey, Bijan K Paul, Nikhil Guchhait

{"title":"Photophysical and thermodynamic landscape of interaction of a styryl-based dye with DNA duplex: effect of medium ionic strength and live cell imaging.","authors":"Viki Bhakta, Zofa Shireen, SanjitDey, Bijan K Paul, Nikhil Guchhait","doi":"10.1007/s43630-025-00693-z","DOIUrl":"10.1007/s43630-025-00693-z","url":null,"abstract":"A red-emitting excited-state intramolecular charge transfer pyridinium dye, [4-((1E,3E)-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-1-methylpyridin-1-ium] (DAPBMP), was synthesized and characterized using NMR and ESIMS studies. Binding interaction between dye DAPBMP and genomic DNA were investigated using steady-state and time-resolved spectroscopic methods. The thermodynamics of the interaction process were characterized using isothermal titration calorimetry (ITC) which reveals the key role of the hydrophobic effect and electrostatic interaction between the positive charged dye and the negatively charged polyphosphate of DNA backbone. The binding of dye to the minor groove of the DNA double helix is confirmed by circular dichroism spectroscopy and molecular docking simulation study. The binding interaction is found to be strongly dependent on the ionic strength of the medium as demonstrated by a systematic study in the presence of various concentrations of NaCl. A detailed calorimetric study shows that polyelectrolytic contribution, ΔGpe, (a measure of the role of electrostatic force) to the total free energy change (ΔG) of interaction progressively decreases with increasing ionic strength of the medium due to weakening of the DAPBMP:DNA binding by screening of the electrostatic charges. The fluorescence of DAPBMP exhibits a remarkable emission enhancement of almost 15 times when the viscosity of the water-propylene glycol system increases. Fluorescent microscopy was performed with C2C12 mouse skeletal myoblast and A549 lung cancer cells in the presence of DAPBMP dye. The dye passed through the C2C12 cell membrane and binds the negatively charged nucleic acids, essentially double-stranded DNA which made the nuclear puncta along with perinuclear located mitochondria.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"307-326"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xanthomonas campestris pv. campestris regulates virulence mechanisms by sensing blue light. 油菜黄单胞菌。Campestris通过感应蓝光调节毒力机制。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1007/s43630-025-00694-y

V P Conforte, J Rinaldi, H R Bonomi, A Festa, D Garacoche, S Foscaldi, E Castagnaro, A A Vojnov, F Malamud

{"title":"Xanthomonas campestris pv. campestris regulates virulence mechanisms by sensing blue light.","authors":"V P Conforte, J Rinaldi, H R Bonomi, A Festa, D Garacoche, S Foscaldi, E Castagnaro, A A Vojnov, F Malamud","doi":"10.1007/s43630-025-00694-y","DOIUrl":"10.1007/s43630-025-00694-y","url":null,"abstract":"Light is an environmental stimulus to which all living organisms are exposed. Numerous studies have shown that bacteria can modulate virulence factors through photoreceptor proteins. Xanthomonas campestris pv. campestris (Xcc) is the causative agent of the systemic vascular disease black rot, which affects cruciferous crops worldwide. Typical symptoms include V-shaped yellow lesions emanating from the leaf margins and blackening of the leaf veins. In previous work, we have shown that Xcc possesses a functional bacteriophytochrome (XccBphP) that regulates its virulence in response to red and far-red light. In addition to the XccBphP protein the Xcc genome codes for a blue light photoreceptor, a Light Oxygen Voltage (LOV) domain-containing protein with a histidine kinase (HK) as the output module. Here, we show that both photoreceptors are able to sense blue light. We demonstrated that XccLOV is a functional photoreceptor by performing loss and gain of function experiments with a knock-out and a complemented strain for the lov gene. Blue light negatively affected swimming motility, whereas xanthan production was regulated by XccBphP, in a blue light independent manner. Additionally, our studies showed that blue light altered biofilm structure patterns and enhanced virulence. Overall, these results revealed that some Xcc virulence factors are blue light modulated via at least two photoreceptors.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"327-342"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sunscreens in pigmentary disorders: time to revise the message. 防晒霜对色素紊乱的影响：是时候修改信息了。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-02-01 Epub Date: 2025-02-24 DOI: 10.1007/s43630-025-00688-w

Sahngeun Jenny Mun, Vanessa Lee, Monisha Gupta

引用次数: 0

Synthesis and biological activity, photophysical, photochemical properties of tetra substituted magnesium phthalocyanine. 四取代酞菁镁的合成及其生物活性、光物理、光化学性质。

IF 2.7 3区化学

Photochemical & Photobiological Sciences Pub Date : 2025-02-01 Epub Date: 2025-02-15 DOI: 10.1007/s43630-025-00686-y

Sadin Özdemir, Derya Güngördü Solğun, Gülay Giray, Mehmet Salih Ağırtaş

{"title":"Synthesis and biological activity, photophysical, photochemical properties of tetra substituted magnesium phthalocyanine.","authors":"Sadin Özdemir, Derya Güngördü Solğun, Gülay Giray, Mehmet Salih Ağırtaş","doi":"10.1007/s43630-025-00686-y","DOIUrl":"10.1007/s43630-025-00686-y","url":null,"abstract":"The compound 4-(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalonitrile was obtained from the reaction of 2-nitrophenol, 4-nitrophthalonitrile and 2-mercaptobenzimidazole. This compound was reacted with magnesium Chloride (MgCl2) to yield tetrakis-[(2-((1H-benzo[d]imidazol-2-yl) thio) phenoxy) phthalocyaninato] magnesium II. New compounds were characterized by UV-vis, 1H NMR, 13C NMR, FTIR and Mass spectra. Electronic spectra aggregation study of magnesium phthalocyanine compound in various concentrations and diverse solvents was performed. Photoluminescence spectra of magnesium phthalocyanine in different solvents were investigated. The biological activities of 3 and 4 compounds were investigated. The results showed that 4 had excellent antioxidant and antidiabetic activities as 75.71% and 81.83%, respectively. 3 and 4 had deoxyribonucleic acid (DNA) cleavage ability and 4 caused a double-strand fracture in plasmid DNA at 100 and 200 mg/L. Both compounds showed antimicrobial activity and also 4 was more effective against pathogenic microorganisms than 3. Photodynamic antimicrobial therapy of test compound was also more effective than without irradiation. The highest biofilm inhibition of 3 and 4 was 78.28% and 98.49% for S. aureus and also 73.95% and 91.13% for P. aeruginosa, respectively. Finally, both compounds demonstrated %100 microbial cell viability inhibition at 100 mg/L. Overall, the study suggests that both 3 and 4 have potential for further development as therapeutic agents.","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"277-292"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0