Photochemical & Photobiological Sciences最新文献

{"title":"Solvatochromism and cis-trans isomerism in azobenzene-4-sulfonyl chloride.","authors":"İsa Sıdır, Yadigar Gülseven Sıdır, Halil Berber, Rui Fausto","doi":"10.1007/s43630-025-00684-0","DOIUrl":"10.1007/s43630-025-00684-0","url":null,"abstract":"<p><p>Solvatochromism exhibited by azobenzene-4-sulfonyl chloride (here abbreviated as Azo-SCl) has been investigated in a series of non-polar, polar-aprotic and polar-protic solvents. The UV-vis spectra of Azo-SCl exhibit two long-wavelength bands, observed at 321-330 nm (band-I) and 435-461 nm (band-II), which are ascribed to the π*-π (S₂ ← S₀) and π*-n (S₁ ← S₀) transitions, respectively. The shorter wavelength band indicates a reversal in solvatochromism, from negative to positive solvatochromism, for a solvent with a dielectric constant of 32.66 (which is characteristic of methanol), while the longer wavelength band signposts negative solvatochromism in all range of solvent's dielectric constant investigated, demonstrating different interactions with the solvents in the S₂ and S₁ excited states. Using Catalán and Kamlet-Taft solvation energy models, we found that the shift in the solvatochromic behavior of band-I (S₂ ← S₀) happens because solvent dipolarity/polarizability and hydrogen bonding affect the S₂ state in opposite ways. Dipolarity/polarizability stabilizes the S₂ state compared to the ground state, while hydrogen bonding destabilizes it. In contrast, for S₁, both effects work together to destabilize the excited state. For all studied solvents, UV irradiation (λ ≥ 311 nm; room temperature) was found to lead to fast trans-cis azo photoisomerization. In the absence of light, the photogenerated cis form quickly converts back to the trans form. Interpretation of the experimental data is supported by quantum chemical calculations undertaken within the Density Functional Theory (DFT) framework, including Time Dependent DFT calculations for excited states.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"261-275"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactions to disclosed biofeedback information on skin DNA damage in individuals after a beach holiday: a mixed methods intervention study.","authors":"Nynne Johanne Sahl Frederiksen, Ida Schwarz Thorsteinsson, Catharina Margrethe Lerche, Jonatan Riber Granborg, Merete Hædersdal, Peter Dalum, Brian Køster","doi":"10.1007/s43630-024-00677-5","DOIUrl":"10.1007/s43630-024-00677-5","url":null,"abstract":"<p><strong>Background: </strong>The incidence of skin cancer among Danes is one of the highest in the world. Most skin cancers are, however, avoidable with sun protection and reduction of exposure. One way to increase awareness could be through personal biofeedback information about skin DNA damage.</p><p><strong>Objective: </strong>This study investigates the influence of biofeedback information about skin DNA damage on Danish beach holiday travelers' perception of risk of developing skin cancer and motivations for behaviour change.</p><p><strong>Methods: </strong>The intervention experiment included 20 participants aged 36-56 years, travelling to destinations with a high UV-index in February/March 2023. A new technology for detecting skin DNA damage in urine was used. Each participant was required to provide urine samples before and after travelling on holiday and participate in an interview about risk perceptions. The interviews were semi-structured and included the disclosure of DNA damage obtained during the holiday. Risk perceptions were assessed using a scale before and after the disclosure of biofeedback information.</p><p><strong>Results: </strong>We identified key elements affecting perceived susceptibility of skin cancer as well as central barriers for behaviour change. The intervention increased risk perceptions for 35% of participants, and 30% expressed intentions to adopt more sun protective practices. However, most participants' perceived susceptibility to skin cancer did not change significantly, as the DNA damage still appeared too abstract.</p><p><strong>Conclusion: </strong>The findings suggest that biofeedback information can increase risk perceptions related to skin cancer and initiate intended behaviour change for some. Larger scale studies are needed and should include quantification of the individual DNA damage thereby making the assessed risk more relatable and personally relevant.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"235-245"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Nicotinamide mononucleotide blocks UVB-induced collagen reduction via regulation of ROS/MAPK/AP-1 and stimulation of mitochondrial proline biosynthesis.","authors":"Yue Zhang, Chen Ai, Fangzhou Huang, Ji-Li Zhao, Yixin Ling, Weijing Chen, Zhenzhu Li, Yu Wang, Fei Gao, Siqi Li, Wei Gao, Yu-Shuai Wang","doi":"10.1007/s43630-025-00692-0","DOIUrl":"10.1007/s43630-025-00692-0","url":null,"abstract":"<p><p>β-Nicotinamide mononucleotide (NMN), as a precursor of long-lived protein co-factor nicotinamide adenine dinucleotide (NAD⁺) in the human body, has demonstrated promising clinical value in treating photoaging and skin wounds. Previous research showed that NMN possessed significant skin protection against UVB-induced photoaging and promoted collagen synthesis. However, its potential mechanism remains unclear. This study aimed to investigate whether NMN improved UVB-induced collagen degradation by regulating ROS/MAPK/AP-1 signaling and stimulating mitochondrial proline biosynthesis. The results showed that NMN notably inhibited UVB-induced ROS production and down-regulated the MAPK/AP-1 signaling pathway. In addition, NMN significantly increased proline levels in mitochondria, which acted as the primary raw materials for collagen synthesis. Further mechanistic analysis revealed that NMN increased the levels of mitochondrial NAD⁺ and NADP(H). Besides, NMN supplementation activated pyrroline-5-carboxylatesynthetase (P5CS), a key enzyme in proline biosynthesis, by increasing SIRT3 levels. However, the promoting effects of NMN on proline and collagen synthesis were significantly inhibited when 3-TYP, a SIRT3 inhibitor, was combined applied. Meanwhile, the effects of NMN on collagen synthesis were reversed when the solute carrier family 25 member 51, a mammalian mitochondrial NAD⁺ transporter, was knocked down. Moreover, animal experiments indicated that NMN ameliorated UVB-induced collagen fiber degradation by activating the SIRT3/P5CS signaling. These results revealed that NMN could combat UVB-induced collagen depletion by regulating the ROS/MAPK/AP-1 and proline synthesis.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"293-306"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of ultraviolet filters and their impact on aquatic environments.","authors":"Garett J Grant, Henry W Lim, Tasneem F Mohammad","doi":"10.1007/s43630-024-00674-8","DOIUrl":"10.1007/s43630-024-00674-8","url":null,"abstract":"<p><p>Numerous anthropogenic ultraviolet filters (UVF) have been detected in aquatic environments and concerns have arisen regarding their potential impacts on aquatic organisms. This manuscript reviews the environmental concentrations and potential toxicity of various UVF. The highest concentrations of UVF are typically observed near frequently visited recreational areas and during peak water-activity periods, which suggests that sunscreen application correlates with noticeable alterations in UVF concentrations. Aquatic concentrations of certain filters have sporadically exceeded 10 μg/L, although most measurements remain below 1 µg/L, which is below commonly reported toxicity levels. UVF have also been detected in aquatic organisms, typically ranging from nondetectable levels to a few hundred ng/g, depending on the species. The toxic effects from UVF, such as coral bleaching and diminished growth, have been observed in laboratory settings, however, toxicity tends to manifest only at significantly higher levels than what is typically detected in aquatic environments. Further research is imperative to provide consumers with improved guidance on selecting sunscreen containing UVF that poses the least environmental risk.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"343-356"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing antitumour immunity with photodynamic therapy.","authors":"Pål Kristian Selbo, Mladen Korbelik","doi":"10.1007/s43630-025-00690-2","DOIUrl":"10.1007/s43630-025-00690-2","url":null,"abstract":"<p><p>In this perspective, we present and discuss pre-clinical and some clinical studies demonstrating that local photodynamic therapy (PDT) per se is a treatment modality that can induce systemic anti-tumour immunity, however, the anti-tumour efficacy is strongly enhanced when PDT is combined with other treatment modalities, e.g., vaccines or ICI therapy. PDT has been recognized for over 30 years as a modality inducing strong immune effects in treated tumours. More recently, PDT has become perceived as a distinct type of immunogenic antitumor modality with an attractive potential for use as unique form of clinical cancer immunotherapy. It can be argued that PDT-inflicted tumour tissue injury provokes in situ vaccination effect. In the end of this perspective paper, we express our opinion of challenges and future directions in the field of PDT and PDT + immunotherapy.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"227-234"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photophysical behavior of meso-N-butylcarbazole-substituted BODIPY in different nano-scale organized media.","authors":"E Anjana, Iti Gupta, Ashok Kumar Mishra","doi":"10.1007/s43630-024-00678-4","DOIUrl":"10.1007/s43630-024-00678-4","url":null,"abstract":"<p><p>The present work focuses on the photophysical behavior of meso-N-butylcarbazole-substituted BODIPY (CBZ-BDP) in different organized media towards exploring the possible use of the dye as a molecular sensor and imaging agent. The molecule shows an appreciable change in absorption and emission spectra at 75% water-acetonitrile mixture compared to pure acetonitrile. In water-acetonitrile mixture, it displays aggregate-induced emission (AIE) bands. New emission peaks are observed at 560 nm and 630 nm, corresponding to LE (locally excited) and ICT (intramolecular charge transfer) states of CBZ-BDP aggregates. The fluorescence anisotropy studies of CBZ-BDP in glycerol medium show its better sensitivity towards the microenvironment. CBZ-BDP was used to probe various microheterogeneous systems like bile salts, pluronics, and lipid bilayer systems in aqueous medium. The dye displays sensitive variation in emission intensity and fluorescence anisotropy in sodium cholate (NaC) bile salt in aqueous medium as a function of the bile salt concentration. The molecule detects the temperature-induced phase transitions in pluronic P123 and F127, as well as 1,2-dimyristoylphosphatidylcholine (DMPC) and 1,2-dipalmitoylphosphatidylcholine (DPPC) lipid bilayer systems in aqueous medium. These studies strongly suggest that CBZ-BDP can be used as an efficient fluorescent probe in sensing the micro-environmental changes in bile salts, pluronics, and lipid bilayers in aqueous medium. The imaging studies of CBZ-BDP-embedded Giant Unilamellar Vesicles (GUVs) were carried out. The molecule stains the lipid bilayers and displays bright-green fluorescent images, suggesting its potential in lipid bilayer imaging.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"131-147"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"21^st century surface UV radiation changes deduced from CMIP6 models: part I-evolution of major influencing factors.","authors":"A Chatzopoulou, K Tourpali, A F Bais, P Braesicke","doi":"10.1007/s43630-024-00675-7","DOIUrl":"10.1007/s43630-024-00675-7","url":null,"abstract":"&lt;p&gt;&lt;p&gt;For a given solar elevation, the levels of solar ultraviolet radiation at the Earth's surface are determined by the amounts of ozone, aerosols, and clouds, as well as by the reflectivity of the surface. Here, we study the evolution of these factors for three selected decades in the period 1950-2100 using results from simulations with Earth-System models (ESMs) participating in the 6&lt;sup&gt;th&lt;/sup&gt; phase of the Coupled Model Intercomparison Project (CMIP6). The simulations for the future are based on three Shared Socioeconomic Pathways: SSP1-2.6, SSP3-7.0, and SSP5-8.5. The models were grouped according to whether they use prescribed ozone fields or interactive chemistry schemes for ozone, revealing significant differences in the absolute levels and variability of total ozone column between the two groups of models. From mid-twenty-first century onward, the ozone recovery is evident in both groups under SSP3-7.0 and SSP5-8.5, but not under SSP1-2.6. The changes in the aerosol optical depth show distinct geographical patterns that are related to their sources, either natural (i.e., dust, biomass burning) or anthropogenic (industrial activities). The aerosols are generally more abundant in 1990-2000 compared to 1950-1960, particularly over regions with industrial activity, with a reversal of this pattern in 2090-2100. Most of these patterns are present in all three pathways, but with different signs compared to 1990-2000 in some regions (i.e., Europe, North America). Over areas with strong natural sources, the aerosol optical depth (AOD) in 2090-2100 increases further under all pathways. The changes in surface reflectivity are important mainly at the end of the twenty-first century and occur predominantly at the high and polar latitudes of both hemispheres, with reductions relative to 1950-1960 of up to 45% due to sea ice retreat. The alterations in the attenuation of shortwave solar radiation by changing cloudiness (expressed in the form of the cloud modification factor, CMF) are more evident at high latitudes, with decreases in 2090-2100 over the Arctic ranging from -5% (SSP1-2.6) to -13% (SSP5-8.5) and smaller decreases of up to -5% in the vicinity of the Antarctic coast. The simulations of ozone, aerosols, surface reflectivity, and clouds for the recent past (2003-2012) were compared to the Copernicus Atmosphere Monitoring Service (CAMS) reanalysis data, showing for total ozone better agreement to models with interactive ozone chemistry. The model-derived AOD shows significant differences from CAMS in various regions worldwide, with up to 0.2 higher values across the northern hemisphere. Finally, the comparisons for surface reflectivity and cloud effects οn this decadal scale reveal a general agreement between models and observations over most of the globe. Thus, we conclude that the projected changes have a good basis in the recent past, suggesting they are realistic estimates of how factors influencing solar ultraviolet radiation may diffe","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"89-109"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation in sunlight exposure is differently associated with changes in T regulatory and T-helper 17 cell blood counts in adolescent and adults females: a pilot study.","authors":"Margaret S Clark, Michael Christie, Melinda Jones, Sarah Ashley, Mimi L K Tang","doi":"10.1007/s43630-024-00668-6","DOIUrl":"10.1007/s43630-024-00668-6","url":null,"abstract":"<p><p>Higher prevalence of multiple sclerosis at higher latitudes is associated with reduced sunlight during childhood. Alterations in inflammatory Th17 and regulatory T cells (Treg) are associated with autoimmunity. In Hobart, Australia (latitude 42.8° south), thirteen girls (aged 12-13) and sixteen women had blood collected in the evening in daylight in February/March, (post 15 h daylight) and at the same time in the dark in August/September (post 9 h daylight). Height and weight were measured. Participants completed online surveys prior around menstruation, sleep, exercise and time outside. Proportions of Th17 (CD4 + , CXCR3-, CCR4 + , CCR6 + , CD161 +), total Treg (CD4 + , CD25 + , CD127low), naïve Treg (CD45RA + , CD4 + , CD25 + , CD127low) and memory Treg (CD45RA low, CD4 + , CD25 + , CD127low) were enumerated by flow cytometry (Cytek Aurora). Hours spent outside was greater in summer than winter (12.5 v 10.5, p = 0.0003). The %Treg/CD4 + was higher in summer than winter (7.3% vs 7%, p = 0.004) including memory Treg (3.1% vs 2.9%, p = 0.02) for all females (n = 29), and naïve Treg were 13% higher in summer in women (3.2% vs 2.8%, p = 0.0009), whereas %Th17 remained unchanged. In women, a negative correlation between the number of hours spent outside in summer and %Th17 was observed (r = - 0.53, p = 0.035). The %Th17 cells were higher in women than girls (4.9% vs 3.1%, p = 0.001), whereas girls had a higher total %Treg (7.6% vs 6.7%, p = 0.005), consisting of a higher naïve Treg (5.5% vs 3.7%, p = 0.0001) while the women had a higher %memory Treg (3.4% vs 2.6%, p = 0.0001). These light-dependent seasonal differences may influence immune development in adolescents.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"23-35"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-first century surface UV radiation changes deduced from CMIP6 models. Part II: effects on UV index and plant growth weighted irradiance.","authors":"Anthi Chatzopoulou, K Tourpali, A F Bais, P Braesicke","doi":"10.1007/s43630-024-00676-6","DOIUrl":"10.1007/s43630-024-00676-6","url":null,"abstract":"<p><p>This paper investigates the evolution of changes in surface ultraviolet (UV) radiation globally, emphasizing the significant impacts of key factors influencing its variability, i.e., total column ozone, aerosols, clouds, and surface reflectivity. Simulations of UV radiation were performed by the UVSPEC radiative transfer model and span from the mid-twentieth century to the end of the twenty-first century. Input data were derived from eleven Earth System Models that participated in the 6th Phase of the Coupled Model Intercomparison Project (CMIP6). The UV Index (UVI) simulations for the late twentieth century indicate an increase in UVI levels relative to the 1950s in the Southern Hemisphere's mid and high latitudes, attributed to ozone depletion, and decreases in southeastern Asia due to increases in aerosols. Projections of changes in UVI for the last decade of the twenty-first century were derived for three Shared Socioeconomic Pathways (SSPs): SSP1-2.6, SSP3-7.0, and SSP5-8.5. Under SSP1-2.6, the scenario with the lowest greenhouse gas (GHG) and aerosol emissions, UVI is projected to increase relative to the 1950s by up to 20% in Europe and North America and to decrease by as much as - 10% over tropical and polar regions. Under SSP3-7.0 and SSP5-8.5, scenarios with higher GHG and aerosol emissions, UVI changes are generally negative globally due to ozone recovery and increases in aerosol optical depth, while localized positive changes are found over Central and South America, Europe, Africa, and the Pacific and Indian Oceans. The changes in the biologically effective solar irradiance for plant growth exhibit similar geographical patterns to UVI with slight differences, due to weaker sensitivity to changes in ozone.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"113-130"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxation process of photoexcited berberine via aggregation and dissociation state-dependent intramolecular electron transfer.","authors":"Kazutaka Hirakawa, Toji Matsuura, Yoshinobu Nishimura, Hakan Mori, Shinsuke Takagi","doi":"10.1007/s43630-024-00673-9","DOIUrl":"10.1007/s43630-024-00673-9","url":null,"abstract":"<p><p>The fluorescence quantum yield of berberine in aqueous solution is significantly smaller than those of organic solution. The time profile of fluorescence intensity of berberine was analyzed by a bi-exponential function, showing that two kinds of states of berberine exist in the solutions. The observed fluorescence lifetime of shorter lifetime species of berberine in water (0.08 ns) was markedly smaller than those of organic solvents and the relative amplitude of the shorter lifetime was dominated in the aqueous solution. Thus, this shorter lifetime can be explained by the deactivation via intramolecular electron transfer. These two states of berberine were independent of pH. The enthalpy and entropy changes between these two states were - 23.2 kJ mol^-1 and - 90 J K^-1 mol^-1, supporting the aggregation of berberine. In the aggregation state, an electrostatic interaction between cationic berberine and chloride ion decreases the electron accepting ability of the isoquinoline moiety of berberine, resulting in the suppression of intramolecular electron transfer. Furthermore, in the presence of clay, the interaction between berberine and clay increased the fluorescence intensity of berberine and its lifetime, showing that the negative charge of clay suppresses the intramolecular electron transfer. Since the electron transfer quenching of the photo-excited berberine is advantageous for suppressing the phototoxic effect of berberine, the inhibition of berberine aggregation is an important process for the phototoxicity prevention.</p>","PeriodicalId":98,"journal":{"name":"Photochemical & Photobiological Sciences","volume":" ","pages":"79-87"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}