Photodynamic therapy could serve as a promising approach to prevent posterior capsular opacification.

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Photochemical & Photobiological Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI:10.1007/s43630-025-00707-w

Yifan Liu, Yihan Huang, Zhihui Yang, Lechun Lyu, Yue Li

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Abstract

Posterior capsular opacification (PCO) causes the vision that has been restored after cataract surgery to become blurred again. YAG laser treatment for PCO not only incurs additional costs but also poses risks of complications, including glaucoma and retinal disorders. Effective prevention and management of PCO remain an area requiring active research. Photodynamic therapy (PDT) utilizes a photosensitizer (PS) to transform oxygen into reactive oxygen species (ROS) under specific wavelengths of light, thereby inducing apoptosis. Given its minimal invasiveness and high specificity, PDT has been extensively applied in the treatment of conditions characterized by abnormal cell proliferation, such as tumors. Considering the pathogenesis of PCO, PDT has demonstrated promising clinical application potential in ophthalmic disease treatment. This review examines the impact of photodynamic therapy on the biological behavior of lens epithelial cells (LECs) and its efficacy in treating PCO. It also discusses the advantages and disadvantages of different photosensitizers and their clinical application potential.

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光动力治疗是预防后囊膜混浊的有效方法。

后囊膜混浊（PCO）导致白内障手术后恢复的视力再次模糊。YAG激光治疗PCO不仅会产生额外的费用，而且还会带来并发症的风险，包括青光眼和视网膜疾病。有效预防和管理PCO仍然是一个需要积极研究的领域。光动力疗法（PDT）利用光敏剂（PS）在特定波长的光下将氧转化为活性氧（ROS），从而诱导细胞凋亡。由于其侵袭性小、特异性高，PDT已广泛应用于肿瘤等以细胞增殖异常为特征的疾病的治疗。考虑到PCO的发病机制，PDT在眼科疾病治疗中具有良好的临床应用潜力。本文综述了光动力疗法对晶状体上皮细胞（LECs）生物学行为的影响及其治疗PCO的效果。讨论了不同光敏剂的优缺点及其临床应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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