ACS Applied Nano Materials最新文献

{"title":"Magneto-Mechanical Nanoscale Actuation in Cancer Therapeutics: A Review","authors":"Yara Maayah,&nbsp;Sakura Rieck,&nbsp;Samuel Minier,&nbsp;Dhanushi Dedakia,&nbsp;Juan Beltran-Huarac","doi":"10.1021/acsanm.6c04336","DOIUrl":"https://doi.org/10.1021/acsanm.6c04336","url":null,"abstract":"<p>Magneto-mechanical actuation (MMA) is a potent tool in nanomedicine, particularly in cancer therapeutics. Recent studies have demonstrated the capabilities of MMA to induce significant cell death using magnetic nanoparticles (MNPs) remotely actuated by super-low frequency alternating magnetic fields (AMFs) without inducing detectable heat (nhMMA). The applications of MMA vary widely, including the physical disruption of cells to improve drug delivery and its use in conjunction with existing therapies (polytherapies) to amplify therapeutic outcomes. With so many different parameters, such as particle design (size and morphology), magnetic field dosage (frequency, amplitude, duration, and exposure mode), and cell type, that directly impact specific therapeutic outcomes, a summary of the main findings reported in the literature is imperative to understand the mechanism and origin of MMA. Nanoparticle design dictates their magnetic ordering and how they behave in biological settings, including an active role in cellular uptake, intracellular distribution, and physical interaction with organelles. Critically important is the magnetic response of MNPs in uniform AMFs and their corresponding mechanical torque, which can be tailored by physicochemical and magnetic parameters. In this sense, MNPs are artificially engineered to execute a specific action in single therapies and polytherapies, whether physical disruption of a subcellular target or the entire cell is required. Recent reports indicate that nhMMA can disrupt cell membranes, cytoskeletons, lysosomes, mitochondria, and membrane ion channels, thus triggering cell death through apoptosis or necrosis. This review aims to provide the relevant background, explain current and pragmatic considerations for study designs, and summarize study parameters, findings, and mechanisms that govern MMA. This review also accentuates the necessity for uniform magnetic exposures to generate reliable and reproducible data and reduce conflicting and contradicting inter-laboratory data reported in the literature. The therapeutic customization and remote control make MMA a tremendous tool to effectively pursue the treatment of cancer globally at any specialized level.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20505–20527"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Flow Vortex Fluidic Fabrication of Crumpled rGO/MoS2 Composites for Hydrogen Evolution Catalysis","authors":"Thaar M. D. Alharbi,&nbsp;Amjad E. H. Alotaibi,&nbsp;Mohammed Alahmadi,&nbsp;Renad Almuqhathawi,&nbsp;Mahmoud Moussa,&nbsp;Shan He,&nbsp;Mazen R. Alrahili,&nbsp;Nessrin A. Kattan,&nbsp;Colin L. Raston","doi":"10.1021/acsanm.6c03308","DOIUrl":"https://doi.org/10.1021/acsanm.6c03308","url":null,"abstract":"<p>High-yield crumpled reduced graphene oxide (rGO)/MoS₂ composites were produced using continuous-flow processing in a vortex fluidic device (VFD) without surfactants or additional reagents. Intense shear within the dynamic thin film enabled rapid composite formation, generating uniform crumpled structures (0.7−3 μm) by simultaneously jet feeding DMF solutions of MoS₂ and rGO into a 45° tilted rotating tube. The formation of the composite material aligns with established VFD topological flow models, where shear-induced desolvation and interfacial interactions along with high local pressures and temperatures drive sheet crumpling and assembly. This method is scalable, achieving conversion efficiencies of up to ∼95%. The resulting crumpled rGO/MoS₂ structures show promising electrocatalytic activity for the hydrogen evolution reaction, achieving low overpotentials and a Tafel slope of 119 mV dec⁻¹, highlighting their potential as cost-effective water-splitting catalysts.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20624–20633"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surfactant-Like π-Conjugated Axial Ligands Enable Single-Layer Zn-MOF Nanosheets for Fluorescence Sensing of Phenols","authors":"Qianyu Guo,&nbsp;Chengcheng Ye,&nbsp;Xiudu Zhang,&nbsp;Yanshang Kang,&nbsp;Yonghong Ni","doi":"10.1021/acsanm.6c04041","DOIUrl":"https://doi.org/10.1021/acsanm.6c04041","url":null,"abstract":"<p>Metal−organic framework (MOF) nanosheets have achieved great success in various fields; however, the preparation of monolayer MOF nanosheets<span></span>particularly via ultrasonic exfoliation<span></span>remains challenging. In this work, we report the synthesis of a Zn(II)-MOF, [Zn(HL)(L)_0.5(bpy)_0.5] (<strong>Zn-1</strong>, where H₂L = 4,4’-[(2,5-dimethoxy-1,4-phenylene)di-2,1-ethenediyl]bis-benzoic acid and bpy = 4,4′-bipyridine), and its successful exfoliation into monolayer nanosheets (<strong>Zn-1-NS</strong>) by ultrasonic treatment. Single-crystal X-ray diffraction revealed that the coordination of Zn²⁺ with L²⁻/HL⁻ and bpy generated two-dimensional (2D) networks, in which the partially deprotonated ligands were oriented vertically on both sides of the layers, resembling a surfactant-like arrangement. These 2D layers were further assembled into a three-dimensional (3D) supramolecular framework through C−H···π and π···π interactions. Ultrasonic exfoliation in isopropanol (IPA) yielded <strong>Zn-1-NS</strong> with a thickness of approximately 4 nm, consistent with the calculated thickness of a single coordination layer (4.19 nm), confirming the formation of monolayer MOF nanosheets. Compared with bulk <strong>Zn-1</strong>, <strong>Zn-1-NS</strong> exhibited enhanced fluorescence and superior sensing performance toward 2,4-dinitrophenol (2,4-DNP) in water, with high selectivity, sensitivity, anti-interference capability, fast response, good recyclability, and a low detection limit (0.14 μM) <em>via</em> a turn-off mechanism. Moreover, application tests in real water samples demonstrated excellent practicability and reliability.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20823–20831"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur-Vacancy-Engineered In2S3 Nanoflowers for Visible-Light-Driven One-Pot Upcycling of Polylactic Acid Waste to Alanine","authors":"Xiaofan Zhou,&nbsp;Feng Niu,&nbsp;Ziqi Dong,&nbsp;Junyan Li,&nbsp;Da Chen","doi":"10.1021/acsanm.6c04330","DOIUrl":"https://doi.org/10.1021/acsanm.6c04330","url":null,"abstract":"<p>The accumulation of polylactic acid (PLA) waste poses a growing environmental challenge, calling for sustainable upcycling strategies that transform waste plastics into value-added chemicals. Here, sulfur-vacancy-engineered In₂S₃ nanoflowers were synthesized through a facile hydrothermal method and applied as an efficient photocatalyst for visible-light-driven one-pot upcycling of PLA into alanine. The optimized In₂S₃−S_0.2 catalyst exhibited an alanine formation rate of 3.32 mmol·g⁻¹·h⁻¹ at 50 °C under visible-light irradiation. Structural and photoelectrochemical characterizations revealed that the enhanced activity of In₂S₃−S_0.2 was mainly attributed to the sulfur-vacancy-induced bandgap narrowing, suppressed charge-carrier recombination, and strengthened reduction capability toward imine intermediates. Combined with radical-trapping experiments and in situ EPR analysis, PLA was sequentially transformed through ammonolysis and photocatalytic amination pathways involving lactamide, ammonium lactate, carbon-centered radicals, amino radicals, and imine intermediates before alanine formation. Moreover, the catalyst exhibited excellent stability and enabled the direct conversion of post-consumer PLA products into alanine. This work demonstrates an effective defect-engineering strategy for sustainable photocatalytic upcycling of biodegradable plastics into value-added amino acids.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20907–20915"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FeCo−N−C Nanostructures Derived from Metal−Organic Frameworks as a Bifunctional Catalyst for Oxygen Reduction and Hydrogen Evolution Reactions","authors":"Jiaojie Wang,&nbsp;Aijia Yu,&nbsp;Liya Chen,&nbsp;Qixiang Chen,&nbsp;Qianshan Guo,&nbsp;Shiping Luo,&nbsp;Aijuan Xie","doi":"10.1021/acsanm.6c03546","DOIUrl":"https://doi.org/10.1021/acsanm.6c03546","url":null,"abstract":"<p>Developing high-efficiency nanoscale electrocatalysts is essential to advancing energy conversion and storage technologies for sustainable development. Among various alternatives, transition metal nanoparticles supported on N-doped carbon nanomaterials have emerged as attractive substitutes for noble-metal-based catalysts due to their excellent activity in both the oxygen reduction reaction (ORR) and the hydrogen evolution reaction (HER). In this work, a bifunctional nanocatalyst based on a metal−organic framework (MOF)-derived FeCo−N−C nanocomposite was fabricated via pyrolysis of an iron-cobalt MOF precursor. The FeCo−N−C nanocatalyst delivered an ORR onset potential of 0.987 V and a half-wave potential of 0.91 V (vs. RHE), retaining 83% of its initial current after 30 h and outperforming commercial Pt/C in long-term durability and methanol tolerance. Moreover, it exhibited excellent HER performance, characterized by a low overpotential of 105 mV at −10 mA cm⁻² (vs. RHE), a Tafel slope of 87 mV dec⁻¹, and a small charge-transfer resistance of 12.68 Ω. This work offers a nanoscale alloying strategy for designing MOF-derived bimetallic carbon nanocomposites as high-performance bifunctional nanocatalysts for renewable energy applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20682–20692"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-Dimensional LaNb2O7 Nanosheets for UV Wavelength-Selective Neuromorphic Vision and Temporal Computing","authors":"Yanhui Li,&nbsp;Jiayi Li,&nbsp;Linglong Wu,&nbsp;Yong Zhang,&nbsp;Jiaxin Chen","doi":"10.1021/acsanm.6c03834","DOIUrl":"https://doi.org/10.1021/acsanm.6c03834","url":null,"abstract":"<p>In recent years, neuromorphic synaptic devices have emerged as an important hardware for building neuromorphic vision systems, due to their ability to simultaneously encode, store and process information during perception. However, most neuromorphic vision research has focused on the visible light band, and the utilization of ultraviolet (UV) spectral information remains limited. Meanwhile, device systems that integrate wavelength discrimination with brain-like temporal processing are still lacking. Here, we report a UV photo-synaptic device based on two-dimensional (2D) LaNb₂O₇ (LNO) nanosheets. Benefiting from the wide bandgap property of LNO and the defect-induced persistent photoconductivity, this device exhibits a significant wavelength-dependent response in the UVA, UVB and UVC regions, together with synaptic plasticity and temporal memory characteristics. Using a 5 × 6 device array, image perception and dynamic memory under different UV regions were achieved. In addition, based on the device response characteristics, proof-of-concept demonstrations for static image classification and continuous action recognition tasks were carried out, highlighting its potential for neuromorphic vision applications. This work offers a insights for the application of wide bandgap 2D oxides in UV neuromorphic devices, and provides a material basis as well as device guidance for the development of low-power intelligent vision systems.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20743–20754"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Cobalt Nanocatalyst on Covalently Functionalized Halloysite for Alkoxy- and Aminocarbonylations","authors":"Rodrigo Carmona-Chávez,&nbsp;Karla P. Salas-Martin,&nbsp;Alejandro Serrano-Maldonado,&nbsp;Jérôme Esvan,&nbsp;Itzel Guerrero-Ríos,&nbsp;Montserrat Gómez,&nbsp;Antonio Reina,&nbsp;Daniel Pla","doi":"10.1021/acsanm.6c03990","DOIUrl":"https://doi.org/10.1021/acsanm.6c03990","url":null,"abstract":"<p>Herein, we report the design of a bifunctional nanocatalyst comprising cobalt nanoparticles (CoNPs) and covalently functionalized halloysite nanotubes with peralkylguanidine moieties (HAL-PAG) for alkoxy- and aminocarbonylation processes mediated via dual catalysis. The nano-tubular morphology of naturally occurring halloysite, combined with peralkylguanidine functionalization, promotes efficient nanoparticle distribution on the support, avoiding agglomeration. A full characterization of the innovative nanomaterials confirms both the successful immobilization and the chemical environment of the CoNPs. Under optimized conditions, the <strong>CoNPs@HAL-PAG</strong> catalyst enables the alkoxy and amino-carbonylation of iodoarenes to the corresponding esters and amides, respectively, in high yields (up to 80%), significantly improved in comparison with the non-functionalized <strong>CoNPs@HAL</strong> catalytic material. <strong>CoNPs@HAL-PAG</strong> exhibits broad substrate scope across various aryl iodides, alcohols, and amines, including the synthesis of the blockbuster drug benzocaine. To the best of our knowledge, this represents one of the first examples of supported dual systems, encompassing both peralkylguanidine as a strong proton acceptor and non-noble metal-based nanoparticles applied to the alkoxy- and aminocarbonylations of aryl halides. This system offers a robust and recyclable catalyst for the sustainable synthesis of aryl esters and amides.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20804–20812"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NiCoP Nanoparticles Supported on ZnIn2S4 Nanosheets as Photocatalyst for Hydrogen Evolution","authors":"Xueyi Wang,&nbsp;Jiaran Qu,&nbsp;Shuang Guo,&nbsp;Zihui Liang,&nbsp;Xiaotian Yang,&nbsp;Ping Wang","doi":"10.1021/acsanm.6c04083","DOIUrl":"https://doi.org/10.1021/acsanm.6c04083","url":null,"abstract":"<p>ZnIn₂S₄ has been extensively investigated for photocatalytic hydrogen (H₂) evolution owing to its suitable electronic structure, visible-light response, and relatively low toxicity. However, rapid recombination of photogenerated charge carriers and photocorrosion severely limit its photocatalytic efficiency and stability. Cocatalyst integration provides an effective strategy for promoting charge separation and introducing additional catalytic sites. Herein, bimetallic nickel-cobalt phosphide (NiCoP) nanoparticles were supported on ZnIn₂S₄ nanosheets through a low-temperature solvothermal method, yielding a NiCoP−ZnIn₂S₄ composite with intimate interfacial contact. Spectroscopic characterization and density functional theory (DFT) calculations collectively indicate ground-state charge redistribution from NiCoP toward ZnIn₂S₄ at the interface. The combined photoresponse and electrochemical results support a cocatalyst mechanism in which photogenerated electrons are proposed to transfer from ZnIn₂S₄ to conductive NiCoP for proton reduction under illumination. Consequently, the optimized NiCoP−ZnIn₂S₄ composite achieves an H₂ evolution rate of 14.73 mmol g⁻¹ h⁻¹ under visible-light irradiation using triethanolamine (TEOA) as the hole scavenger, representing a 20.18-fold enhancement over pristine ZnIn₂S₄. These results underscore the importance of interfacial electronic coupling in regulating ground-state charge redistribution and photogenerated-electron transfer and offer a basis for designing efficient noble-metal-free phosphide/semiconductor photocatalysts for solar H₂ production.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20846–20857"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction of “Integrating Artificial Intelligence via Deep Reinforcement Learning for the Autonomous Discovery of High-Entropy Nanoclusters”","authors":"Muhammad Umar Farooq,&nbsp;Fuyi Chen","doi":"10.1021/acsanm.6c04167","DOIUrl":"https://doi.org/10.1021/acsanm.6c04167","url":null,"abstract":"","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"21003–21003"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionizable Lipid Nanoparticles as a siRNA Delivery Carrier: A Review","authors":"Vishal Prajapat,&nbsp;Gaurav Sharma,&nbsp;Narender K. Dhania,&nbsp;Auhin Kumar Maparu","doi":"10.1021/acsanm.6c03278","DOIUrl":"https://doi.org/10.1021/acsanm.6c03278","url":null,"abstract":"<p>Small interfering RNA (siRNA)-based gene silencing has evolved as a promising strategy for treating a wide range of human diseases. However, naked siRNA molecules are susceptible to degradation by cellular nucleases, immune activation, and rapid renal clearance. Therefore, various siRNA delivery vectors have been developed, among which lipid nanoparticles (LNPs) have received significant attention due to their excellent biocompatibility and low immunogenicity. Conventionally, permanent cationic lipids were used for the fabrication of LNPs, but their clinical translation was limited by cytotoxicity, immunogenicity, and non-specific interactions. To overcome these limitations, significant progress has been made in developing advanced LNPs using ionizable lipids (ILs) (termed as IL nanoparticles or iLNPs) that are neutral at physiological pH but acquire a positive charge in the acidic endosomal compartments, thereby minimizing toxicity and facilitating efficient endosomal escape. This review summarizes the different vectors for siRNA delivery, the evolution of iLNPs, their composition, and surface modification strategies. Furthermore, we discuss the application of iLNP-mediated siRNA therapy for several human diseases, including an FDA-approved therapy. Finally, we highlight the current challenges of iLNP-based siRNA therapeutics and possible artificial intelligence-guided approaches for the rational design and development of next-generation iLNPs for effective siRNA delivery.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 44","pages":"20483–20504"},"PeriodicalIF":5.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}