ACS Applied Nano Materials最新文献

{"title":"Single-Step Additive Manufacturing of Monolithic MXene Architectures for Integrated Wireless Energy Storage in Wearable Electronics","authors":"Zhen You,&nbsp;, ,&nbsp;Yuzhe Chen,&nbsp;, ,&nbsp;Xiaoyuan Jia,&nbsp;, ,&nbsp;Xueqing Chen,&nbsp;, ,&nbsp;Xuan Zhang,&nbsp;, ,&nbsp;Qixiang Wang,&nbsp;, ,&nbsp;Ning Ding,&nbsp;, ,&nbsp;Shujuan Liu,&nbsp;, ,&nbsp;Weiwei Zhao*,&nbsp;, and ,&nbsp;Qiang Zhao*,&nbsp;","doi":"10.1021/acsanm.5c03882","DOIUrl":"https://doi.org/10.1021/acsanm.5c03882","url":null,"abstract":"<p >Flexible energy storage devices with integrated wireless charging units enable compact, mobile power solutions for next-generation wearable electronics. However, conventional multistep hybrid fabrication processes often suffer from interfacial energy losses and limited mechanical flexibility, hindering seamless integration. Here, we present a single-step extrusion printing strategy utilizing rheologically tailored Ti₃C₂ MXene inks to simultaneously print interdigitated microsupercapacitors (MSCs) and wireless charging coils. This approach leverages shear-aligned MXene nanochannels to construct bifunctional modules that achieve 51.9% wireless power transfer efficiency, high areal capacitance (59.36 mF cm^–2), and high energy density (26.71 μWh cm^–2), effectively addressing traditional interfacial limitations. The integrated device exhibits excellent mechanical robustness, maintaining capacitance stability under various bending angles or 10,000 folding cycles. Following only 8 min of wireless charging, it delivers a peak power output of 1.3 mW, outperforming existing planar MSCs. Notably, a 140 s charging period enables continuous operation of a humidity and temperature sensor for 43 min, setting a record-high charge-to-use ratio of 18.4. This study establishes a groundbreaking paradigm for seamless wireless power-storage integration that offers transformative design principles and fabrication strategies for next-generation wearable electronics.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20540–20552"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZnxCo1–x/N-Doped Carbon Nanotube Composites as Electrocatalysts for Hydrogen and Oxygen Evolution","authors":"Dong-Yang Chen,&nbsp;, ,&nbsp;Li-Ying Zhang,&nbsp;, ,&nbsp;Bo-Long Yang,&nbsp;, ,&nbsp;Li-Wei Chen,&nbsp;, ,&nbsp;Yan-Xia Hu,&nbsp;, ,&nbsp;Xin Lu*,&nbsp;, and ,&nbsp;Zuo-Xi Li*,&nbsp;","doi":"10.1021/acsanm.5c03757","DOIUrl":"https://doi.org/10.1021/acsanm.5c03757","url":null,"abstract":"<p >The development of cost-effective bifunctional electrocatalysts with atomic precision for both hydrogen and oxygen evolution reactions (HER/OER) remains critical for sustainable water electrolysis. Herein, we designed a series of two-dimensional (4,4)-networked Zn_<i>x</i>Co_1–<i>x</i>-MOFs through controlled Zn²⁺/Co²⁺ coordination. These were subsequently transformed into metallic Co nanoparticles embedded within N-doped carbon nanotube heterostructures via a simple carbonization process, labeled Zn_<i>x</i>Co_1–<i>x</i>-NCNT. Benefiting from the nanoscale synergistic effects between highly active metallic Co- and N-doped CNTs, as well as the pore-forming role of Zn that generates a hierarchical nanoscale porous architecture, the catalysts exhibit increased specific surface area and abundant exposed active sites. Among these, Zn_0.33Co_0.67-NCNT-1000 demonstrates exceptional electrocatalytic performance, achieving low overpotentials of 147 mV for the HER and 281 mV for the OER at 10 mA cm^–2. Density functional theory calculations reveal near-ideal hydrogen adsorption free energy (Δ<i>G</i>_H* ≈ 0) and reduced OER energy barriers. This work provides a nanostructural engineering strategy for the design of efficient bifunctional electrocatalysts derived from bimetallic MOFs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20486–20498"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Efficient Electrosynthesis of H2O2 by Heteroatom-Doped Carbon Nanosheets for In Situ Sterilization","authors":"Nan Wang*,&nbsp;, ,&nbsp;Shuqing Jiang,&nbsp;, ,&nbsp;Xu Wang,&nbsp;, ,&nbsp;Ruiyong Zhang*,&nbsp;, ,&nbsp;Ini-Ibehe Nabuk Etim,&nbsp;, ,&nbsp;Jizhou Duan,&nbsp;, and ,&nbsp;Baorong Hou,&nbsp;","doi":"10.1021/acsanm.5c03701","DOIUrl":"https://doi.org/10.1021/acsanm.5c03701","url":null,"abstract":"<p >Oxygen reduction reaction (ORR) provides a green alternative route for the efficient production of H₂O₂. It is important to enhance the environmental safety and compliance with the Sustainable Development Goals. Herein, we report a heteroatom-doped reduced graphene oxide (rGO-N/rGO-S/rGO-SN) catalyst, among which rGO-N exhibits good two-electron catalytic performance in a simulated seawater (3.5% NaCl). The rGO-N has higher activity under neutral conditions while maintaining a high H₂O₂ selectivity of 70%. The rGO-N presents an attractive H₂O₂ production amount up to 300 mmol/g/h at a −1.1 mA/cm² current density. The remarkable electrocatalytic activity of rGO-N is attributed to the doping of heteroatom nitrogen changing the electronic structure of the material, which makes it easier for the 2e^– process. Meanwhile, the H₂O₂ selectivity of rGO-N could still reach 45% in natural seawater with complex ions. Interestingly, it was found that the chloride ion promotes the H₂O₂ selectivity of 2e^– ORR. Antibacterial experiments were conducted on the H₂O₂ generated by electrocatalysis in an H-type electrolytic cell. It was found that the sterilization rate during the electrocatalytic process could reach as high as 99% within 30 min in simulated seawater, indicating great potential of the catalyst for future practical applications such as green, effective antibacterial and antifouling in the marine environment.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20450–20462"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Membrane-Camouflaged Cascade Nanozymes Remodel the Hypoxic Tumor Microenvironment for Enhanced Immunotherapy","authors":"Lei Qiao,&nbsp;, ,&nbsp;Wei Huang,&nbsp;, ,&nbsp;Hong-Jie Gao,&nbsp;, ,&nbsp;Jing Zang,&nbsp;, ,&nbsp;Ming-Yu Chen,&nbsp;, ,&nbsp;Meng-Yu Liu,&nbsp;, ,&nbsp;Gui-Song Shan,&nbsp;, ,&nbsp;Long-Hai Wang,&nbsp;, ,&nbsp;Fei Wang*,&nbsp;, and ,&nbsp;Xiao-Yan He*,&nbsp;","doi":"10.1021/acsanm.5c03942","DOIUrl":"https://doi.org/10.1021/acsanm.5c03942","url":null,"abstract":"<p >The hypoxic tumor microenvironment (TME) represents a critical barrier to effective immunotherapy in breast cancer. To address this challenge, we design a cell membrane-camouflaged cascade nanozyme (CMAA) that integrates metabolic reprogramming, oxygen regulation, and immunogenic cell death (ICD) induction. CMAA incorporates MnO₂ nanoparticles with catalase-like activity and Au nanoparticles that mimic glucose oxidase (GOx), establishing a sequential catalytic cascade that alleviates hypoxia, depletes glucose, and generates cytotoxic hydroxyl radicals (^•OH). To further optimize oxygen utilization, atovaquone (ATO), a mitochondrial complex III inhibitor, is introduced to suppress cellular oxygen consumption, thereby synergizing with the catalytic process to enhance oxygen availability. Both in vitro and in vivo, CMAA nanozyme effectively reverses hypoxia, induces ICD characterized by calreticulin (CRT) exposure and high-mobility group box 1 (HMGB1) release, and promotes CD8⁺ T-cell infiltration. In 4T1 murine breast cancer models, CMAA nanozyme achieves significant tumor growth inhibition, reduces lung metastasis (fewer nodules), and elicits abscopal effects on distant tumors. This work establishes a triple-pathway strategy─simultaneously targeting oxygen supply, oxygen demand, and ^•OH amplification─to reprogram the immunosuppressive hypoxic TME. Through oxygen modulation and immune reprogramming, CMAA nanozyme provides a versatile platform for enhancing breast cancer immunotherapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20578–20591"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-Engineered Cobalt Selenide Nanoparticles Supported on Porous Carbon Substrate as Electrocatalyst for Water Splitting","authors":"Kamonpan Wongyai,&nbsp;, ,&nbsp;Sittipong Kaewmorakot,&nbsp;, ,&nbsp;Yuwanda Injongkol,&nbsp;, ,&nbsp;Mohamed Siaj,&nbsp;, and ,&nbsp;Sujittra Poorahong*,&nbsp;","doi":"10.1021/acsanm.5c03566","DOIUrl":"https://doi.org/10.1021/acsanm.5c03566","url":null,"abstract":"<p >The development of stable and efficient electrocatalysts is essential for the advancement of water splitting technologies. Herein, we present a simple strategy for directly growing nanoscale cobalt selenide (CoSe) on a macroporous conducting carbon substrate (PCS) to form binder-free electrocatalysts. Notably, the nanoscale phases and morphologies of CoSe can be readily adjusted by altering the electrodeposition process. Through repeated chronoamperometry, tetragonal phase CoSe (t-CoSe) was obtained, whereas hexagonal-phase CoSe (h-CoSe) is achieved using cyclic voltammetry. Optimized t-CoSe@PCS demonstrated superior hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performance, achieving overpotentials of 59.4 and 290 mV with Tafel slopes of 40 and 44.9 mV dec^–1, respectively. For overall water splitting, a cell voltage of only 1.76 V was required at 10 mA cm^–2, with excellent stability maintained for over 25 h. Density functional theory (DFT) calculations indicated that hydrogen adsorption was more favorable on h-CoSe; however, the enhanced activity of t-CoSe was attributed to its porous structure, higher electrochemical surface area, and increased Co³⁺ content, which promoted charge transfer and active site accessibility. These findings underscore the significance of phase engineering and structural design in enhancing the electrocatalyst performance for efficient overall water splitting.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20363–20373"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biocompatible Water-Soluble Silicon Quantum Dots for Photodynamic Cancer Therapy","authors":"Artjima Ounkaew,&nbsp;, ,&nbsp;David Antoniuk,&nbsp;, ,&nbsp;Jonathan G. C. Veinot,&nbsp;, ,&nbsp;Melissa Bouvier,&nbsp;, ,&nbsp;Iren Constantinescu,&nbsp;, ,&nbsp;William Tees-DeBeyer,&nbsp;, ,&nbsp;Selina Hung,&nbsp;, ,&nbsp;Jayachandran N. Kizhakkedathu,&nbsp;, and ,&nbsp;Ravin Narain*,&nbsp;","doi":"10.1021/acsanm.5c03568","DOIUrl":"https://doi.org/10.1021/acsanm.5c03568","url":null,"abstract":"<p >This study reports the development of silicon quantum dots (SiQDs) designed as water-soluble and biocompatible materials for biomedical applications by functionalizing mixed surfaces of 10-Undecenoic acid (acid-SiQDs) and poly(ethylene oxide) (acid-PEO-SiQDs) through thermally induced hydrosilylation. The SiQDs exhibited exceptional biocompatibility with cell viability exceeding 95% and negligible toxicity at concentrations up to 500 μg/mL after 24 h of culture. In vitro photodynamic therapy (PDT) studies under low-level near-infrared (NIR) laser irradiation demonstrated significant therapeutic efficacy, reducing cancer cell viability to below 50% at concentrations of 250 μg/mL for acid-SiQDs and 50 μg/mL for acid-PEO-SiQDs after 10 min of irradiation. In vitro hemocompatibility of the SiQDs was investigated by measuring red blood cell hemolysis and aggregation, plasma coagulation, and platelet activation studies, which demonstrate that the surface modified SiQDs do not show adverse effects. Additionally, the SiQDs exhibited a red photoluminescent quantum yield exceeding 30%, further underscoring their structural stability and functional versatility. Collectively, these findings highlight the potential of acid-SiQDs and acid-PEO-SiQDs as safe, multifunctional platforms for enhancing cancer therapy through NIR irradiation while maintaining favorable blood compatibility, paving the way for their application in advanced biomedical technologies.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20397–20410"},"PeriodicalIF":5.5,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nickel Telluride Electrochemical Sensor for the Detection of the Antibiotic Ronidazole","authors":"Tara Barwa,&nbsp;, ,&nbsp;Ramaraj Sukanya,&nbsp;, ,&nbsp;Thamaraiselvi Kanagaraj,&nbsp;, ,&nbsp;Gillian Collins,&nbsp;, ,&nbsp;Yiran Luo,&nbsp;, ,&nbsp;Eithne Dempsey,&nbsp;, ,&nbsp;Raj Karthik,&nbsp;, ,&nbsp;Jae-Jin Shim,&nbsp;, and ,&nbsp;Carmel B. Breslin*,&nbsp;","doi":"10.1021/acsanm.5c03794","DOIUrl":"https://doi.org/10.1021/acsanm.5c03794","url":null,"abstract":"<p >The widespread use of nitroimidazole antibiotics such as ronidazole (RON) in human and veterinary medicine raises concerns about environmental persistence and antimicrobial resistance. Sensitive detection of trace RON in water is therefore essential. Here, we report for the first time, nickel telluride nanoparticles (NiTe NPs) as an electrochemical sensor specifically designed for RON detection. NiTe, a transition metal chalcogenide with high conductivity and electrocatalytic activity, was synthesized via a simple hydrothermal method and characterized by X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. When drop-cast on a glassy carbon electrode, the NiTe NPs significantly enhanced electron transfer and promoted efficient electrochemical reduction of RON. The sensor achieved a detection limit of 1.5 nM, a wide linear range of 0.01–270 μM, and a sensitivity of 0.489 μA μM^–1 cm^–2. It also displayed excellent selectivity against common interferents and maintained stability and reproducibility during extended testing. Application to spiked tap and river water confirmed accurate recovery. This work highlights NiTe as an underutilized telluride-based material and establishes its novel application in the environmental monitoring of antibiotic contaminants, addressing a critical gap in electrochemical sensing research.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20523–20533"},"PeriodicalIF":5.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing Nanomechanics by Direct Indentation Using Nanoendoscopy-AFM Reveals the Nuclear Elasticity Transition in Cancer Cells","authors":"Takehiko Ichikawa*,&nbsp;, ,&nbsp;Yohei Kono,&nbsp;, ,&nbsp;Makiko Kudo,&nbsp;, ,&nbsp;Takeshi Shimi,&nbsp;, ,&nbsp;Naoyuki Miyashita,&nbsp;, ,&nbsp;Tomohiro Maesaka,&nbsp;, ,&nbsp;Kojiro Ishibashi,&nbsp;, ,&nbsp;Kundan Sivashanmugan,&nbsp;, ,&nbsp;Takeshi Yoshida,&nbsp;, ,&nbsp;Keisuke Miyazawa,&nbsp;, ,&nbsp;Rikinari Hanayama,&nbsp;, ,&nbsp;Eishu Hirata,&nbsp;, ,&nbsp;Kazuki Miyata,&nbsp;, ,&nbsp;Hiroshi Kimura,&nbsp;, and ,&nbsp;Takeshi Fukuma*,&nbsp;","doi":"10.1021/acsanm.5c03044","DOIUrl":"https://doi.org/10.1021/acsanm.5c03044","url":null,"abstract":"<p >The assessment of nuclear structural changes is considered a potential biomarker of metastatic cancer. However, accurately measuring nuclear elasticity remains challenging. Traditionally, nuclear elasticity has been measured by indenting the cell membrane with a bead-attached atomic force microscopy (AFM) probe or aspirating isolated nuclei with a micropipette tip. However, indentation using a bead-attached probe is influenced by the cell membrane and cytoskeleton, while measurements of isolated nuclei do not reflect their intact state. In this study, we employed Nanoendoscopy-AFM, a technique in which a nanoneedle probe is inserted into a living cell to directly measure nuclear elasticity and map its distribution. Our findings show that nuclear elasticity increases under serum depletion but decreases when serum-depleted cells are treated with TGF-β, which induces epithelial–mesenchymal transition (EMT). Furthermore, we found that changes in nuclear elasticity correlate positively with trimethylation levels of histone H4 at lysine 20, rather than with nuclear lamins expression levels. These findings suggest that alterations in chromatin structure underlie changes in nuclear elasticity during the progression of cancer.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20239–20249"},"PeriodicalIF":5.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c03044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immobilization of Quantum Dot-DNA Conjugates Templated by DNA Self-Assembled Monolayers on Single-Crystal Gold Bead Electrodes Toward Advanced Sensing","authors":"Daina V. Baker,&nbsp;, ,&nbsp;W. Russ Algar,&nbsp;, and ,&nbsp;Dan Bizzotto*,&nbsp;","doi":"10.1021/acsanm.5c03549","DOIUrl":"https://doi.org/10.1021/acsanm.5c03549","url":null,"abstract":"<p >The controlled assembly of quantum dots (QDs) on electrode surfaces is challenging but of interest for the development of sensors and other bioanalytical platforms. Here, we demonstrate the DNA-templated assembly of QDs on a gold electrode. QDs conjugated with complementary DNA were hybridized with a fluorescently labeled single-stranded DNA self-assembled monolayer (SAM) on a single-crystal gold bead electrode. Colocalization of QD and fluorophore photoluminescence from the modified surface indicated that the QD coverage was correlated to the facet-dependent density of the underlying DNA-SAM. AFM imaging of the assembled QD-DNA SAM on the Au(111) facet showed QDs at a density of ∼1 × 10¹⁰ particles/cm² or roughly 100 nm between QDs, consistent with the mobility of the DNA-templated QD SAMs measured using potential-induced reorientation. QDs did not assemble on a dsDNA SAM, DNA-free SAMs, nor if the QDs lacked conjugated complementary DNA. QDs desorbed with the DNA-SAM during reductive desorption of the thiol, and with the chemical and thermal denaturation of the dsDNA SAM. These observations supported a DNA-mediated assembly process. However, at low ionic strength, the anionic QDs were also removed from the surface, pointing to a competition between DNA hybridization and electrostatic repulsion between the QDs and the DNA SAM. Additionally, QDs lacking conjugated DNA were found to aggregate on mercaptohexanol-coated gold and on clean gold. These aggregated QDs were not removed via reductive electrochemistry and required very high forces to be displaced using AFM. Interfacial DNA was thus critical to the controlled and reversible binding of QDs at the gold surface. Overall, we have shown the preparation of QD-SAMs using a DNA-templated approach, and developed in situ methodology to assess the modified interface and the stability on the surface-bound QDs. This insight will guide the rational preparation of well-defined QD-modified electrode surfaces.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20341–20351"},"PeriodicalIF":5.5,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-Microenvironment-Responsive Mesoporous Manganese Oxide for Photo-Chemotherapy of Glioma","authors":"Feng Wei,&nbsp;, ,&nbsp;Xiaoning Lin,&nbsp;, ,&nbsp;Jiang Zhu,&nbsp;, ,&nbsp;Xinhua Tian,&nbsp;, ,&nbsp;E. Chen,&nbsp;, ,&nbsp;Yuhao Zhang,&nbsp;, ,&nbsp;Baofang Wu,&nbsp;, ,&nbsp;Jiayin Wang,&nbsp;, ,&nbsp;Liya Xie,&nbsp;, ,&nbsp;Xiaohang Liu,&nbsp;, ,&nbsp;Jinyan Lin*,&nbsp;, and ,&nbsp;Hongzhi Gao*,&nbsp;","doi":"10.1021/acsanm.5c03474","DOIUrl":"https://doi.org/10.1021/acsanm.5c03474","url":null,"abstract":"<p >Photochemotherapy has shown great potential for glioma treatment due to its synergistic effects and lower systemic toxicity. However, challenges like the hypoxic tumor microenvironment, insufficient tumor-specific accumulation, and inadequate cellular internalization efficiency still limit its clinical effectiveness. To tackle these issues, we developed a virus-like hollow mesoporous manganese oxide (vHMMn) nanocage coloaded with Temozolomide (TMZ) and indocyanine green (ICG), and surface-functionalized with DSPE-PEG-rabies virus glycopeptide-29 (DSPE-PEG-RVG29). This design aims to boost cellular uptake and alleviate tumor hypoxia for more effective photochemotherapy. After accumulating in tumor tissues via the enhanced permeability and retention (EPR) effect, the nanocage (TMZ/ICG-loaded vHMMn with DSPE-PEG-RVG29, denoted as TI@vHMMnR) could be efficiently and quickly taken up by tumor cells through virus-like surface-assisted cellular adhesion and nicotinic acetylcholine receptor (nAchR)-mediated endocytosis. When exposed to laser irradiation, the nanocage could produce a large amount of reactive oxygen species (ROS), causing mitochondrial dysfunction. At the same time, the vHMMn nanocage could catalyze endogenous H₂O₂ into oxygen to increase intratumoral oxygen levels, reversing hypoxia and enhancing phototherapeutic efficacy. Moreover, the nanocage could be degraded by the high levels of glutathione (GSH) inside tumor cells, releasing TMZ to cause DNA damage. Our nanocage integrates tumor targeting, hypoxia relief, and photochemotherapy, offering a promising approach for glioma treatment.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 42","pages":"20314–20328"},"PeriodicalIF":5.5,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}