ACS Applied Nano Materials最新文献

{"title":"Ag Nanostars in Capillary-Enabled Digital SERS Quantification of Trace Hg2+","authors":"Jie Jiang,&nbsp;, ,&nbsp;Yuan Gan,&nbsp;, ,&nbsp;Shen Shen,&nbsp;, ,&nbsp;Ning Sun,&nbsp;, ,&nbsp;Yong Zhu*,&nbsp;, and ,&nbsp;Jie Zhang*,&nbsp;","doi":"10.1021/acsanm.5c03234","DOIUrl":"https://doi.org/10.1021/acsanm.5c03234","url":null,"abstract":"<p >Mercury (Hg), as a highly toxic heavy metal pollutant, poses severe threats to ecological systems and human health even at trace concentrations of ppt levels. Current detection technologies face challenges including insufficient sensitivity, poor anti-interference capability, and complex operational procedures. This study proposes a capillary quartz tube-based silver nanostar (Ag NS) digital surface-enhanced Raman scattering (SERS) method for highly sensitive detection of trace Hg²⁺. The approach amplifies Raman scattering signals through localized surface plasmon resonance (LSPR) and tip-enhanced effects of Ag NSs, integrated with a digital signal recognition strategy via digital SERS (dSERS), and the intensity-fluctuating SERS signals were converted into digital signals “1” and “0” via predetermined threshold optimized analysis. Ag NSs with tunable tip structures were synthesized via a seed-mediated growth method. Electromagnetic simulations demonstrated significant SERS enhancement originating from the tip architecture. Specific coordination between diethylenetriaminepentaacetic acid (DTPA) ligands and Hg²⁺ induced a carboxyl vibrational peak shift, enabling sensitive Hg²⁺ detection. Experimental results revealed that the digital quantification model based on statistical analysis of SERS-active signals exhibited excellent linear response (<i>R</i>² = 0.99) from 100 ppb to 10 ppt, achieving a detection limit of 10 ppt. The spike recovery error in real water sample analysis was maintained below 10%. This study provides an innovative solution for trace heavy metal detection in complex environments, demonstrating simultaneous ultrahigh sensitivity and anti-interference capability.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18829–18837"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Flexible, Mechanically Robust Absorbed Electromagnetic Interference Shielding Textiles via Aqueous Polyurethane Modification with a CoFe2O4@rGO Nanometer Composite","authors":"Zhuolun Li,&nbsp;, ,&nbsp;Xiaoxia Tian*,&nbsp;, ,&nbsp;Jiafu Wang,&nbsp;, ,&nbsp;Jun Wang,&nbsp;, and ,&nbsp;Shaobo Qu,&nbsp;","doi":"10.1021/acsanm.5c03629","DOIUrl":"https://doi.org/10.1021/acsanm.5c03629","url":null,"abstract":"<p >Responding to the growing need for flexible materials with superior electromagnetic shielding performance, this research focuses on synthesizing cobalt ferrite@reduced graphene oxide (CoFe₂O₄@rGO) nanopowder through a solvothermal synthesis technique. The synthesized nanophase material was then blended with water-based polyurethane to form an EMI slurry, which was subsequently deposited onto a blended fabric base via a simple dip-coating method. A critical factor driving the material’s performance lies in the synergistic electromagnetic interaction between rGO and CoFe₂O₄, which imparts favorable electromagnetic characteristics to the nanocomposite. This interaction enables an exceptional electromagnetic shielding performance. The resulting flexible fabric achieved an EMI shielding effectiveness of 27.6 dB while maintaining an ultraslim thickness of 0.66 mm. Concurrently, the notable flexibility of these blended fabric-based EMI composites, combined with the straightforward dip-coating method fabrication approach, substantially expands the practical application scope of such flexible electromagnetic absorption materials. To conclude, this cost-efficient, flexible, tough, and high-performing EMI shielding fabrics, developed through a simple and scalable synthesis approach, exhibits promising practical potential in civilian applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"19035–19044"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ar Plasma-Assisted SO32– Intercalation into NiFe Layered Double Hydroxides for Improved Performance in the Oxygen Evolution Reaction","authors":"Zihao Chen,&nbsp;, ,&nbsp;Liang Liang Sun*,&nbsp;, ,&nbsp;Yongxin Wu,&nbsp;, ,&nbsp;Jian Luo,&nbsp;, ,&nbsp;Peiyao Xue,&nbsp;, ,&nbsp;Jipeng Yan,&nbsp;, ,&nbsp;XIngbiao Deng,&nbsp;, and ,&nbsp;Yuyang Feng,&nbsp;","doi":"10.1021/acsanm.5c02899","DOIUrl":"https://doi.org/10.1021/acsanm.5c02899","url":null,"abstract":"<p >Chemical intercalation plays a crucial role in enhancing the performance of nickel–iron layered double hydroxide (NiFe LDH) catalysts for the oxygen evolution reaction (OER). By introducing specific ions, the catalytic sites within NiFe LDH are optimized, thereby facilitating efficient water oxidation. In this study, we inserted SO₃^2– into NiFe LDH using Ar plasma. This process created a two-dimensional (2D)–three-dimensional (3D) petal-shaped p-NiFe LDH–SO₃^2– electrode. The p-NiFe LDH–SO₃^2– composite shows an excellent electrocatalytic performance. At a current density of 10 mA cm^–2, the overpotential is just 194 mV. During a long-term OER test at the same current density, the overpotential changes by only 1.57%. SO₃^2– has a strong electrodissociation effect, keeping metal ions in a high valence state and producing NiOOH/FeOOH. It also increases interlayer spacing, leading to more active sites and better OER performance. The results indicate that using Ar plasma technology to prepare the SO₃^2– intercalated NiFe LDH is advantageous. This method offers low energy consumption, precise control, and simple processes. Compared with previous studies, this technology enhances the intercalation efficiency of SO₃^2–. It also allows changes in the interlaminar spacing of LDH, which helps create more active sites.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18772–18780"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrogen-Doped Carbon Quantum Dot Nanoparticle Fluorescent Probes for Quantification of Ni(II) in Environmental Water Samples Collected using an Unmanned Aerial Vehicle","authors":"João Paulo de Almeida,&nbsp;, ,&nbsp;Jackson Rodrigo Silva,&nbsp;, ,&nbsp;José Roberto Sabino-Júnior,&nbsp;, ,&nbsp;Vinícius A. Carvalho,&nbsp;, ,&nbsp;Willian Toito Suarez,&nbsp;, ,&nbsp;Miguel M. Erenas,&nbsp;, ,&nbsp;Luis Fermin Capitán-Vallvey,&nbsp;, ,&nbsp;Severino Carlos Oliveira,&nbsp;, and ,&nbsp;Vagner Bezerra dos Santos*,&nbsp;","doi":"10.1021/acsanm.5c03254","DOIUrl":"https://doi.org/10.1021/acsanm.5c03254","url":null,"abstract":"<p >In this work, an innovative and low-cost method was developed to quantify Ni(II) ions in environmental water samples based on fluorescence digital images from quantum dots using a smartphone as a detector. The method is based on the fluorescence quenching of nitrogen-doped carbon dots (N,C-QDs) when nickel reacts with dimethylglyoxime. The fluorescence emission from nanoparticles is captured by a smartphone coupled to a portable UV-LED chamber. An analytical curve was developed to detect Ni(II), and a concentration range from 10.9 to 275.0 μg L^–1 with detection and quantification limits of 2.7 and 8.3 μg L^–1, respectively. Thus, the method attempted the recommended values of Ni(II) according to agencies such USEPA (100 μg L^–1), WHO (70 μg L^–1), EFSA (20 μg L^–1), and CONAMA (25 μg L^–1) for fresh waters. Moreover, to evaluate the accuracy and precision of the proposed method, a reference method based on inductively coupled plasma-optical emission spectrometry was used for comparison purposes. The results obtained by both methods showed no differences at a 95% confidence level (<i>n</i> = 3) when employing the F-test and T-test statistical methods. Furthermore, the fluorescence digital image-based (FDIB) method was highly selective for Ni(II) ions with an interference response lower than 5.0%, and it presented a good recovery from 93.6 to 109.0%. Moreover, aiming to develop a high-level automation method for environmental monitoring, an adapted unmanned aerial vehicle (UAV) controlled by a smartphone via Wi-Fi, equipped with a micropump and a miniaturized solenoid valve powered by a solar energy system, was developed. This innovation reduced collection time, allowed access to hard-to-reach locations, and reduced sampling costs by using renewable energy, thus being environmentally friendly. This new analytical method using N,C-QDs-FDIB-UAV proposed for monitoring Ni(II) in environmental water samples offers numerous advantages, such as high sensitivity, selectivity supplied by nanoparticle probe together the portability, low cost, autonomous, and an eco-friendly methodology obtained from the UAV system.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18838–18852"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c03254","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resin-Templated Synthesis of Platinum Nanozymes with Dual Oxidase and Peroxidase Activity for Dopamine Detection","authors":"Tingting Ma,&nbsp;, ,&nbsp;Xiangdong Wang,&nbsp;, ,&nbsp;Xinran Yang,&nbsp;, ,&nbsp;Yuyan Mao,&nbsp;, and ,&nbsp;Maoguo Li*,&nbsp;","doi":"10.1021/acsanm.5c03316","DOIUrl":"https://doi.org/10.1021/acsanm.5c03316","url":null,"abstract":"<p >A cost-effective and easily implemented approach is reported for the creation of a bifunctional nanozyme for sensitive dopamine (DA) detection. The synthesis centers on a unique platform: the use of an anion exchange resin to effectively immobilize platinum precursors (PtCl₆^2–), and optimizing the subsequent pyrolysis process through urea-assisted calcination. This method leads to the formation of nitrogen-doped carbon-supported platinum nanoparticles (Resin Pt@N) with Pt minimal platinum loading (∼2.29 wt %), the number of platinum atoms accounts for only 0.15%. Comprehensive characterization (SEM, TEM, XRD, XPS, and EDS) confirms the successful generation of Pt nanoparticles encapsulated within a nitrogen-doped carbon matrix. The synthesized nanozyme exhibits robust dual enzyme-like activities (oxidase and peroxidase), promoting the oxidation of chromogenic substrates with favorable reaction kinetics. Based on its peroxidase activity, the colorimetric sensor for DA detection was designed to utilize DA’s ability to inhibit the enzymatic reaction between TMB and H₂O₂. The sensor exhibits a strong linear response for DA within the 1.0–100.0 μM range with a detection limit of 0.123 μM, along with excellent selectivity, and the practical utility substantiated by accurate DA quantification in human serum samples. The straightforward synthetic route and the high performance of the analytical platform pave the way for the use of Resin Pt@N in point-of-care diagnostics and biomedical research applications.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18914–18923"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tertiary S-Nitrosothiol Functionalized Mesoporous Silica Nanoparticles for Nitric Oxide Delivery","authors":"Rajnish Kumar,&nbsp;, ,&nbsp;Tsian D. Ramrattan,&nbsp;, and ,&nbsp;Mark H. Schoenfisch*,&nbsp;","doi":"10.1021/acsanm.5c03029","DOIUrl":"https://doi.org/10.1021/acsanm.5c03029","url":null,"abstract":"<p >The exogenous delivery of nitric oxide (NO) as a therapeutic is challenging due to NO’s high reactivity and short half-life. Owing to NO’s many physiological functions, the development of NO-releasing materials for sustained and long-term NO delivery has been a focus of much research. Herein, we report the synthesis of an organosilane bestowing a tertiary thiol (3° SH) moiety derived from (3-aminopropyl)trimethoxysilane and N-acetyl-<span>d</span>-penicillamine thiolactone (NAP-thiolactone). The resulting tertiary thiol-bearing organosilanes (NAPTMS) were covalently tethered to mesoporous silica nanoparticles (MSNs) to generate 3° SH-enriched MSNs (MSN-NAP) that, when nitrosated, formed NO-releasing mesoporous silica nanoparticles (MSN-SNAP). The morphological and thermomechanical properties of MSN-NAP and MSN-SNAP proved suitable as potential therapeutic materials, with NO payloads (1.39 ± 0.15 μmol mg^–1) approximately ten times greater than previously reported tertiary <i>S</i>-nitrosothiol (3° RSNO) systems. In contrast to other reports, MSN-SNAP exhibits a sustained NO-release profile for &gt;24 h under physiological conditions. The MSN-SNAP thus represents a promising NO-releasing prodrug for various biomedical applications that require sustained NO delivery at low concentrations (pM to nM).</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18806–18816"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photothermally Responsive Liquid Crystalline Elastomer/Carbon Nanotube Nanocomposite Actuators with Orthogonal Light-Driven Actuation and Reprogrammability","authors":"Gautam Das,&nbsp;, ,&nbsp;Ji-Ye Kwon,&nbsp;, and ,&nbsp;Soo-Young Park*,&nbsp;","doi":"10.1021/acsanm.5c03433","DOIUrl":"https://doi.org/10.1021/acsanm.5c03433","url":null,"abstract":"<p >This study presents photothermally responsive liquid crystalline elastomer (LCE)/multiwalled carbon nanotube (MWCNT) nanocomposites that enable light-only actuation, self-healing, and reprogramming without thermal treatment. The nanocomposites are fabricated by dispersing MWCNTs using a main-chain mesogenic liquid crystalline oligomer containing disulfide bonds (SS-oligomer) and embedding them in an allyl selenide-containing main-chain LCE (LCE_Se) matrix. Notably, polymerization, monodomain generation, self-healing, and actuation of the prepared LCE_Se/MWCNT nanocomposite occur solely under light irradiation. The MWCNTs in the nanocomposite serve as photothermal agents. They enable actuation through NIR light irradiation and exhibit outstanding properties, including 1.5 MPa actuation stress, 60% actuation strain (Δε), &gt;400% failure strain, 308.3 kJ m^–3 work capacity, heating to 200 °C under light irradiation, and only 13% loss of Δε after 100 NIR light on/off cycles. The allyl selenide linkages enable dynamic exchange reactions (DER) through UV (or visible) light irradiation, which facilitates self-healing and reprogrammability. In particular, the orthogonality between the thermal actuation (driven by photothermal effects under NIR or visible light) and DER (triggered by UV light) ensures stable, fatigue-resistant operation. These combined features establish the LCE_Se/MWCNT nanocomposites as a versatile platform for adaptive materials capable of complex motions such as cantilever bending, lateral locomotion on water surfaces, and bipedal walking.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18975–18989"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular-Weight-Directed Confinement Growth of CsCu2I3@PEG Nanocrystals: Morphology Control, Ultrastable Luminescence, and Multilevel Thermal Encryption for High-Efficiency LEDs","authors":"Yu Zhang,&nbsp;, ,&nbsp;Yiyuan Pao,&nbsp;, ,&nbsp;Lin Wang,&nbsp;, ,&nbsp;Hsin-Han Peng,&nbsp;, and ,&nbsp;Hsiang-Chen Chui*,&nbsp;","doi":"10.1021/acsanm.5c03288","DOIUrl":"https://doi.org/10.1021/acsanm.5c03288","url":null,"abstract":"<p >Metal halide perovskites have attracted substantial interest in lighting and display technologies in recent years. However, their commercial viability remains limited by poor stability and the toxicity of lead, underscoring the urgent need for efficient and environmentally friendly alternatives. Copper-based perovskites have emerged as promising candidates due to their abundant raw materials, low cost, excellent solution processability, and compatibility with low-temperature synthesis. In this study, we systematically investigate the influence of poly(ethylene glycol) (PEG) molecular weight on the structural, optical, and stability characteristics of CsCu₂I₃ perovskite composites through a molecular-weight engineering strategy. Furthermore, we demonstrate their innovative applications in high-efficiency light-emitting devices (LEDs) and dynamic information encryption. Using a room-temperature antisolvent method, we achieved tunable interactions between PEG and the perovskite material, from surface coordination at low PEG molecular weights to internally confined growth at high molecular weights, via ion–dipole interactions between PEG chain −O– groups and Cu⁺ ions. UV–vis absorption and Raman spectroscopy reveal that strong Cu–O coordination in high-molecular-weight PEG effectively suppresses nonradiative recombination, yielding a photoluminescence quantum yield (PLQY) of 81.86% for the <i>M</i>n = 6 M composite. Stability assessments show that this composite retains over 90% of its initial performance under harsh conditions. Moreover, yellow-emitting LEDs based on the <i>M</i>n = 6 M composite exhibit an extrapolated operational half-life of 110 days, with only a 13.6% efficiency decline after 30 days of continuous operation. Leveraging the distinct thermal responses of composites with gradient PEG molecular weights (1 K–6 M), we also developed a quadruple-level dynamic encryption system. This system utilizes programmable temperature control to enable multilevel information decryption governed by temperature–time dual-variable coordination.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"18885–18896"},"PeriodicalIF":5.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsanm.5c03288","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate-Specific Membrane Antigen (PSMA)-Directed Dendrimer–Camptothecin Conjugate for Targeted Treatment of Prostate Cancer","authors":"Anubhav Dhull,&nbsp;, ,&nbsp;Anunay James Pulukuri,&nbsp;, ,&nbsp;Aqib Iqbal Dar,&nbsp;, ,&nbsp;Nina Julia Palmer,&nbsp;, ,&nbsp;Joan Castaneda Gonzalez,&nbsp;, ,&nbsp;Anu Rani,&nbsp;, ,&nbsp;Rishi Sharma,&nbsp;, ,&nbsp;Clifford E. Berkman,&nbsp;, and ,&nbsp;Anjali Sharma*,&nbsp;","doi":"10.1021/acsanm.5c03528","DOIUrl":"10.1021/acsanm.5c03528","url":null,"abstract":"<p >Prostate cancer (PC) remains a major global health challenge, particularly in its advanced, treatment-resistant form. Although Camptothecin (Campto) is a potent topoisomerase I inhibitor with strong antiproliferative and pro-apoptotic activity, its clinical utility is limited by poor aqueous solubility, instability, and systemic toxicity. To address these challenges, we developed a prostate-specific membrane antigen (PSMA)-targeted dendrimer-Camptothecin conjugate (PD-Campto-CTT1298) that improves drug solubility, enables receptor-mediated uptake, and enhances therapeutic effects. This platform was synthesized by conjugating Campto and a high-affinity PSMA ligand (CTT1298) to a generation-4 hydroxyl-terminated PAMAM dendrimer (PD) via copper-catalyzed and strain-promoted azide–alkyne cycloaddition reactions. The resulting conjugate exhibited high aqueous solubility, formulation stability, and efficient drug loading. <i>In vitro</i> drug release studies demonstrated pH- and esterase-responsive Campto release mimicking the tumor microenvironment. PD-Campto-CTT1298 showed selective uptake in PSMA-positive PC cells (PC3-PIP, C4-2B), leading to enhanced cytotoxicity, apoptosis induction, mitochondrial dysfunction, and reactive oxygen species generation. Confocal imaging and flow cytometry confirmed receptor-specific internalization via clathrin-mediated endocytosis. Moreover, PD-Campto-CTT1298 suppressed VEGF-A secretion and disrupted angiogenesis in HUVEC tube formation assays, indicating antiangiogenic activity. Combination therapy with Olaparib demonstrated synergistic effects. Overall, PD-Campto-CTT1298 represents a promising strategy for PSMA-targeted prodrug delivery, offering a multifaceted therapeutic approach through enhanced solubility, intracellular release, and PSMA-positive tumor-specific enhanced cytotoxicity.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"19012–19034"},"PeriodicalIF":5.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zwitterionic Carbon Nanodot-Desferrioxamine Conjugate for Improved Efficacy in Iron Overload Therapy","authors":"Pradnya K. Pachpatil,&nbsp;, ,&nbsp;Jitesh S. Rathee,&nbsp;, ,&nbsp;Avik Chakraborty,&nbsp;, ,&nbsp;Somnath Kar,&nbsp;, ,&nbsp;Seema V. Kanojia,&nbsp;, ,&nbsp;Aniruddh Gupta,&nbsp;, ,&nbsp;Kaustava Bhattacharyya,&nbsp;, ,&nbsp;Nitin D. Waghmare,&nbsp;, and ,&nbsp;Dibakar Goswami*,&nbsp;","doi":"10.1021/acsanm.5c03967","DOIUrl":"https://doi.org/10.1021/acsanm.5c03967","url":null,"abstract":"<p >Iron overload, be it primary or secondary, has been associated with several physiological dysfunctions including neurodegenerative diseases, heart failure, liver cirrhosis, etc. Iron chelators, e.g., desferrioxamine (DFO), have been widely used to treat iron overload conditions clinically. However, the unwanted biodistribution coupled with the unfavorable pharmacokinetics of DFO has resulted in the search of alternatives. Herein, we report a DFO conjugated carbon nanodot, derived from glucose and glutamate, as an easy-to-synthesize nanochelator that showed kidney-specific biodistribution and improved circulation half-life. Moreover, the nanochelator showed better efficacy in reducing iron overload in mice compared with the parent chelator DFO, without any signs of systemic or cardiotoxicities.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 39","pages":"19065–19075"},"PeriodicalIF":5.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}