{"title":"Tetrahedral DNA Nanostructures as Multifunctional Drug-Delivery Vehicles for Treating Non-Small Cell Lung Cancer","authors":"Sanxia Wang, Haohan Chen, Zongkang Guo, Mohamed Aimene Benariba, Maolin Li*, Ninghan Feng*, Xiaoli Wang, Yuting Zhang and Nandi Zhou*, ","doi":"10.1021/acsanm.4c0505810.1021/acsanm.4c05058","DOIUrl":"https://doi.org/10.1021/acsanm.4c05058https://doi.org/10.1021/acsanm.4c05058","url":null,"abstract":"<p >Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, characterized by a relatively slow growth rate and a propensity toward distant metastases following local spread. These factors present significant challenges in both diagnosis and treatment of NSCLC, particularly for early stage NSCLC. In this study, based on the self-assembled functionalized tetrahedral DNA nanostructure (TDN), a multifunctional drug delivery system has been constructed for NSCLC adenocarcinoma cell line A549 (A549 cells) to achieve intracellular imaging and combined drug delivery. The TDN was self-assembled <i>in vitro</i> and the four vertices of TDN were functionalized with Cy5, s6 aptamer, p28 cell-penetrating peptide and siRNA, respectively. Subsequently, daunorubicin (DAU) was loaded to TDN to obtain DAU@TDN-p28-s6-siRNA through the intercalation in double-stranded DNA. While Cy5 is employed for intracellular tracking and imaging, s6 aptamer is used to target A549 cells and enrich TDN around the cells, and p28 cell-penetrating peptide can facilitate the entrance of TDN into the cells via endocytosis. Once DAU@TDN-p28-s6-siRNA is taken inside the cell, the modified siRNA can bind to the mRNA guiding the translation of ERBB3 protein and down-regulate its expression, ultimately leading to the inhibition of cell growth. Simultaneously, through the targeted delivery, DAU accurately inhibits the tumor cell activity, and thus achieving the synergy with siRNA to inhibit the growth of tumor cells. <i>In vitro</i> experiments have demonstrated that compared to the control, DAU@TDN-p28-s6-siRNA reduces the expression of ERBB3 protein by 71.27%, and reduces the viability of the target cell to 37.84%, as well as exhibits high targeting specificity. Therefore, the development of TDN assemblies provides an efficient way for diagnosis and treatment of tumor cells and has potential in the biomedical field.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27071–27079 27071–27079"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xuhui Guan, Zhili Shen, Lei Chen, Chong Zhang, Chengguo Sun, Yang Du, Bingcheng Hu* and Chao Gao*,
{"title":"A Nitrogen-Rich Nanoporous Ionic Covalent Organic Framework as Iodine Adsorbent in Gaseous and Aqueous Environments","authors":"Xuhui Guan, Zhili Shen, Lei Chen, Chong Zhang, Chengguo Sun, Yang Du, Bingcheng Hu* and Chao Gao*, ","doi":"10.1021/acsanm.4c0530710.1021/acsanm.4c05307","DOIUrl":"https://doi.org/10.1021/acsanm.4c05307https://doi.org/10.1021/acsanm.4c05307","url":null,"abstract":"<p >Adsorbents for iodine capture have shown great potential in the treatment of radioactive nuclear waste. Considering that enriched binding sites and strong binding force are efficient strategies to promote the adsorption capacity of iodine, herein we design and construct a nitrogen-rich ionic nanoporous covalent organic framework (ICOF-TG-DCA) through solvothermal synthesis. ICOF-TG-DCA has been well characterized by various techniques and exhibited long-range order with an ionic skeleton. In addition, the iodine capture of ICOF-TG-DCA was investigated in vapor phase under normal pressure at 350 K and in I<sub>2</sub>/KI aqueous solution, which the material showed iodine vapor adsorption capacity of 5.15 g g<sup>–1</sup> and I<sub>3</sub><sup>–</sup> adsorption capacity of 2.21 g g<sup>–1</sup>, respectively. The results show that the presence of rich nitrogen groups together with ionic interactions is beneficial to the capture of iodine in ICOF-TG-DCA. The work demonstrates that construction of nitrogen-rich ionic covalent organic frameworks is a good strategy to achieve high iodine capture performance.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27318–27324 27318–27324"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metal- and Nitrogen-Codoped Carbon Nanotube Field Emitters for Low-Pressure Hydrogen Sensing","authors":"Guitao Chen, Haijun Luo, Weijin Qian*, Mingliang Dong, Weijun Huang and Changkun Dong*, ","doi":"10.1021/acsanm.4c0528810.1021/acsanm.4c05288","DOIUrl":"https://doi.org/10.1021/acsanm.4c05288https://doi.org/10.1021/acsanm.4c05288","url":null,"abstract":"<p >Metal-doped carbon nanotubes (CNTs) have great potential in hydrogen detection because of their large specific surface areas, good catalytic activity, and numerous defect states. However, CNT-based sensing materials have the problem of insufficient hydrogen sensing responsiveness at low pressure, and the effects of different types of catalytic metals on low-pressure hydrogen sensing are still unknown. In this paper, low-pressure hydrogen sensing properties were studied by construction of Fe/Co/Ni- and nitrogen-codoped CNT cathodes, and the pressure was detected from 10<sup>–7</sup> to 10<sup>–4</sup> Pa. In addition, the hydrogen sensing mechanism was studied using first-principles simulations. The experimental results suggested that the Co–N-codoped CNT cathode exhibits the best hydrogen detection properties with a field mission current increase of 224% in 5 min. Furthermore, the FE current could increase 145% in 1 min at a pressure of 4.28 × 10<sup>–4</sup> Pa, promising for quick detection. The simulation revealed that the work functions of metal- and nitrogen-codoped CNTs decreased rapidly with the increase of hydrogen atoms, leading to the obvious improvement of hydrogen sensing properties. These conclusions not only bring good insights into the hydrogen sensing enhancement mechanism for metal–nitrogen-codoped CNT cathodes but also provide a promising way to develop practical cathodes for quick low-pressure hydrogen detections.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27264–27274 27264–27274"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Song Kang, Guofu Zhang, Runze Zhan, Yuan Xu, Linghong Zhou, Shaozhi Deng, Ningsheng Xu and Jun Chen*,
{"title":"Area-Addressable ZnO Nanowire-Based Cold Cathode Transparent Flat-Panel X-ray Sources for Visual Intraoperative Radiotherapy","authors":"Song Kang, Guofu Zhang, Runze Zhan, Yuan Xu, Linghong Zhou, Shaozhi Deng, Ningsheng Xu and Jun Chen*, ","doi":"10.1021/acsanm.4c0497910.1021/acsanm.4c04979","DOIUrl":"https://doi.org/10.1021/acsanm.4c04979https://doi.org/10.1021/acsanm.4c04979","url":null,"abstract":"<p >X-ray intraoperative radiotherapy (IORT) is an important method for treating specific tumors. Area-addressable transparent flat-panel X-ray source can achieve selective-area radiotherapy and direct optical imaging guide, which could enhance the capability of the current IORT technique and has not been reported to date. In this paper, an area-addressable transparent flat-panel X-ray source was realized using zinc oxide (ZnO) nanowire field emitter arrays (FEAs) and an indium tin oxide (ITO) transparent anode. Planar-gate ZnO nanowire FEAs were fabricated and demonstrated a good addressing performance and uniform electron emission characteristics. A maximum anode current density of 884 μA/cm<sup>2</sup> was measured at one area under gate-addressed emission conditions, and the current fluctuation was approximately 5.8% in 2.5 h. The planar-gated ZnO nanowire FEAs were applied in the transparent flat-panel X-ray source. A radiation dose rate of 5.76 mGy/s was measured at the anode surface of the flat-panel X-ray source under the application of 40 kV anode voltages. The reported X-ray source device has potential applications in advanced intraoperative radiotherapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26988–26995 26988–26995"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Space-Confined Molecular Catalysis toward Electrocatalytic CO2 Reduction on Metal Phthalocyanine@Nitrogen-Doped Carbon Nanosheet","authors":"Hongbing Zheng, Haoran Wu, Liming Qiu, Mingyao Yu, Jiajun Zhou, Hui Xu, Chunmei Lv, Pengfei Tian*, Jitong Wang* and Licheng Ling*, ","doi":"10.1021/acsanm.4c0528010.1021/acsanm.4c05280","DOIUrl":"https://doi.org/10.1021/acsanm.4c05280https://doi.org/10.1021/acsanm.4c05280","url":null,"abstract":"<p >Phthalocyanines have emerged as attractive materials for electrocatalytic carbon dioxide reduction. However, the challenge of finding a support that is stable while maintaining catalytic activity and loading remains elusive. Porous carbon materials are considered reliable substrates for supporting molecular catalysts. Herein, a nitrogen-rich carbon nanosheet (NiPc/NMCN) with multilayer and mesoporous structure is synthesized based on a kinetically controlled self-assembly strategy and used for phthalocyanine loading. The multilayer composite structure of NMCN guides the molecular-scale dispersion of phthalocyanine and plays a crucial role in its catalytic process. Moreover, the phthalocyanine molecules retain their metal-N<sub>4</sub> structure after impregnation. Therefore, the remarkable CO<sub>2</sub> electroreduction properties of phthalocyanine are fully demonstrated. At −0.73 V vs. RHE, NiPc/NMCN achieves the highest CO faradaic efficiency (FE<sub>CO</sub>) of 96.0%. Meanwhile, current densities in membrane electrode module electrolyzers can reach industrial amperage levels, while the FEco remains at 60% at 880 mA cm<sup>–2</sup>. Density functional theory (DFT) indicates that the high performance of NiPc/NMCN is attributed to the significant reduction of the CO<sub>2</sub>RR energy barrier. Phthalocyanines restricted by the porous carbon could produce the intermediate *COOH more rapidly, determining high CO<sub>2</sub>RR selectivity, which is confirmed by in situ (FTIR) spectroscopy. Consequently, the strategy of constructing confined multilayer mesoporous carbon structures provides an avenue for the design of efficient CO<sub>2</sub> reduction molecular catalysts.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27275–27286 27275–27286"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhuo Wang, Hongzhi Wang, Xue Bai, Jiabao Dong, Kexin Zhang, Ke Zhan and Bin Zhao*,
{"title":"Pre-Intercalation of Metal Ions into Ammonium Vanadate Nanostructures toward Advanced Zinc Ion Batteries","authors":"Zhuo Wang, Hongzhi Wang, Xue Bai, Jiabao Dong, Kexin Zhang, Ke Zhan and Bin Zhao*, ","doi":"10.1021/acsanm.4c0510810.1021/acsanm.4c05108","DOIUrl":"https://doi.org/10.1021/acsanm.4c05108https://doi.org/10.1021/acsanm.4c05108","url":null,"abstract":"<p >Aqueous zinc ion batteries (AZIBs) featuring low cost and high safety are attracting considerable interest. More recently, ammonium vanadate, characterized by its high specific capacity, is regarded as a promising cathode material for AZIBs. However, their unstable layered structures and sluggish reaction kinetics limit their further development. To overcome these limitations, metal ions (Na<sup>+</sup> and Zn<sup>2+</sup>) are pre-intercalated into ammonium vanadate to modify the interlayer spacing and enhance charge transfer kinetics. Additionally, the impact of different pre-intercalated ions on the structure and properties of ammonium vanadate is systematically investigated. Furthermore, we successfully synthesized ammonium vanadate cathode materials (Na<sub>0.13</sub>(NH<sub>4</sub>)<sub>0.48</sub>V<sub>2</sub>O<sub>5</sub>·0.6H<sub>2</sub>O, Na<sub>0.13</sub>-NVO) featuring stable nanostructures by optimizing the pre-embedded Na<sup>+</sup> content. In this case, pre-intercalated sodium ions could expand the layer spacing of ammonium vanadate (9.14 Å), reduce the electrostatic interaction of Zn<sup>2+</sup> with the V–O framework, and boost the Zn<sup>2+</sup> diffusion rate. Benefitting from these strengths, the Na<sub>0.13</sub>-NVO electrode exhibits a specific capacity of 365.4 mAh g<sup>–1</sup> at 0.5 A g<sup>–1</sup>, along with a good cycling stability of 98.1% capacity retention over 2000 cycles at 5 A g<sup>–1</sup>. This work supplies further insights into designing ammonium vanadate with pre-embedded metal ions and aids the development of high-performance AZIB cathodes.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27090–27099 27090–27099"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lianyuan Ge, Simin Yuan, Xiaohong Wang, Yi Li, Delun Chen, Yuanyuan Wang, Mingyu Wang*, Yang Cao* and Qiang Wu*,
{"title":"Multifunctional Ti3C2@PDA/CuO2 Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy","authors":"Lianyuan Ge, Simin Yuan, Xiaohong Wang, Yi Li, Delun Chen, Yuanyuan Wang, Mingyu Wang*, Yang Cao* and Qiang Wu*, ","doi":"10.1021/acsanm.4c0539910.1021/acsanm.4c05399","DOIUrl":"https://doi.org/10.1021/acsanm.4c05399https://doi.org/10.1021/acsanm.4c05399","url":null,"abstract":"<p >The escalating threat of antibiotic resistance has necessitated the development of innovative antibacterial strategies. In this study, a nanoplatform, Ti<sub>3</sub>C<sub>2</sub>@PDA/CuO<sub>2</sub>, was engineered to exploit the synergistic effects of photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) under near-infrared (NIR) light irradiation for the effective treatment of bacterial infections. Upon exposure to an 808 nm NIR laser and the application of hydrogen peroxide, the Ti<sub>3</sub>C<sub>2</sub>@PDA/CuO<sub>2</sub> nanoplatform demonstrated robust PTT, PDT and significantly photothermal-enhanced CDT activities. This multimodal therapeutic approach resulted in a pronounced antimicrobial response, as evidenced by <i>in vitro</i> assays that showed an extraordinary reduction in the viability of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, with efficacies of 98.5% and 99.5%, respectively. Our findings contribute significant insights into the design of synergistic antibacterial strategies and offer a promising avenue for the development of advanced antimicrobial interventions.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27387–27399 27387–27399"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phenylboronic Acid-Modified pH/Glucose Dual-Responsive Polymeric Micelles for Targeted Anticancer Drug Delivery","authors":"Sifang Zhao, Fengjiao Chen, Xianwu Chen, Hongze Liang, Hui Tan* and Lingling Zhao*, ","doi":"10.1021/acsanm.4c0467910.1021/acsanm.4c04679","DOIUrl":"https://doi.org/10.1021/acsanm.4c04679https://doi.org/10.1021/acsanm.4c04679","url":null,"abstract":"<p >The tumor microenvironment is characterized by several hallmarks such as an acidic pH and high glucose levels in tumor tissues and increased expression of specific proteins and/or sugars on the surface of tumor cells. These unique hallmarks of tumors can be considered in the design of multifunctional drug delivery nanosystems to improve the efficiency of tumor therapy through targeted drug delivery and specific drug release in the tumor tissue. In this study, phenylboronic acid-modified pH- and glucose-responsive polymer micelles were designed for the targeted delivery of anticancer drugs. The polymeric micelles demonstrated prolonged and pH/glucose-triggered drug release and enhanced cellular internalization by B16F10 cells through a receptor-mediated endocytosis pathway. The polymeric micellar system could inhibit the proliferation of B16F10 cells with IC<sub>50</sub> values lower than those of unmodified micelles. In addition, the polymeric micellar system could markedly suppress cell migration, colony formation, and invasion and promote the apoptosis of B16F10 cells, indicating good anticancer efficiency in vitro. Therefore, this polymeric nanocarrier provides a potential platform for targeted anticancer therapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26813–26824 26813–26824"},"PeriodicalIF":5.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiheterojunction Photodetectors Based on Type-II CdSe-CdTe-ZnTe Heterojunctions: Structural Design and Optimization for an Enhanced Transient Response under UV–Vis–NIR Light","authors":"Jinling Luo, Zhi Zheng, Xia Xiang, Xiaotao Zu*, Wenqiang Lu, Nevaja Ingraham and Weilie Zhou*, ","doi":"10.1021/acsanm.4c0495410.1021/acsanm.4c04954","DOIUrl":"https://doi.org/10.1021/acsanm.4c04954https://doi.org/10.1021/acsanm.4c04954","url":null,"abstract":"<p >Ingenious microstructure design and a suitable multicomponent strategy are still challenging for improving the photodetector performance. In this paper, vertically arranged CdSe-CdTe-ZnTe core–shell nanowire arrays with one-dimensional (1D) bivalve structures have been successfully synthesized by the vapor–liquid–solid growth method assisted by gold catalysts. The core–double-shell nanowires have an average length of 5 μm and a diameter of 10 nm and have been applied in the production of ultraviolet–visible (UV–vis)–NIR photodetectors. Owing to the cascade band edges and the enhanced charge separation, the rate of charge recombination is greatly reduced. In addition, the spatially indirect interband transition of photogenerated carriers breaks the limit of photon energy absorption of the single-component material, thus further extending the detection range to near-infrared light and effectively accelerating the transient response of the photodetector from 3.8 to 0.1 s compared to that based on the CdSe-CdTe single-shell structure. This work proves that the one-dimensional core–double-shell structure can effectively improve the transient response of the photodetector while still maintaining the piezo-phototronic effect-enhanced performance of the core–shell nanowire array.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26962–26969 26962–26969"},"PeriodicalIF":5.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reinforcement Strategies to Improve the Mechanical Properties of Nanofibrous Aerogels: A Review","authors":"Huabin Hu, Jing Wang*, Caiyun Li and Lei Li*, ","doi":"10.1021/acsanm.4c0346510.1021/acsanm.4c03465","DOIUrl":"https://doi.org/10.1021/acsanm.4c03465https://doi.org/10.1021/acsanm.4c03465","url":null,"abstract":"<p >Nanofibrous aerogels (NFAs) are porous materials with high porosity and extremely low density assembled from lapped nanofibers. As a bridge between the microscopic nanoscale and the macroscopic world, NFAs have been widely used in related fields such as thermal insulation, separation, energy conversion, and tissue engineering. However, NFAs are severely limited in applications due to their inadequate mechanical properties. To ensure the structural integrity and performance stability of NFAs in applications, multiple reinforcement strategies are usually required to endow NFAs with suitable mechanical properties adapted to the application. In this review, we systematically study the research progress on the mechanical properties of NFAs in recent years, detailing the enhancement strategies on the mechanical properties of NFAs in four aspects: macroscopic morphology, microstructure, interactions between nanofibers, and nanofiber building units, and outlining their relevant applications. The work in this study aims to provide insights into further developing the mechanical properties of NFAs.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26546–26578 26546–26578"},"PeriodicalIF":5.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}