ACS Applied Nano Materials最新文献

{"title":"Theoretical Study of the Impact and Control of Topological Defects on the Electrical Properties of Single-Walled Carbon Nanotubes: Implications for Carbon-Based Transistor Regulation","authors":"Xiaojing Wang,&nbsp;Qingyang Xu,&nbsp;Hangkong Ouyang,&nbsp;Lining Sun and Li Ma*,&nbsp;","doi":"10.1021/acsanm.4c0437610.1021/acsanm.4c04376","DOIUrl":"https://doi.org/10.1021/acsanm.4c04376https://doi.org/10.1021/acsanm.4c04376","url":null,"abstract":"<p >Single-wall carbon nanotubes (SWCNTs) have unique electrical properties, making them potential silicon and copper replacements in semiconductors and nanointerconnects. Current research focuses on single vacancy defects, needing expansion to other topological defects. In this study, we account for the presence of topological defects and develop a model that demonstrates their impact on the electrical properties of carbon nanotubes (CNTs) by using a degradation coefficient for the conductivity. This study employs density functional theory combined with the nonequilibrium Green’s function method to systematically analyze the influence of various topological defects on the electronic structure and transport characteristics of SWCNTs, using <i>I–V</i> curves, transmission spectra, and 3D transmission spectra. The results indicate that defects of the same type substantially degrade the electronic transport properties of CNTs, with the degree of degradation varying based on the defects’ positions and quantities. This degradation can result in a reduction of over 20% in the electronic transport capacity compared with ideal CNTs. A linear positive correlation exists between the extent of degradation and the magnitude of the defects. Furthermore, the presence of a small number of 5–8–5 defects and Stone–Wales defects can induce bandgap opening from 0.109 to 0.549 eV for the bandgap of (6,6) CNTs. However, a high defect concentration reduces the bandgap, potentially to zero. Notably, regardless of whether the bandgap increases or decreases, the bandgap of (6,6) CNTs remains smaller than the bandgap of (11,0) semiconductor CNTs, leading to the transition of SWCNTs to metallic conductors. Finally, the differential conductivity diagram of CNTs with topological defects was analyzed, demonstrating that introducing specific 5–8–5 defects can effectively regulate the electrical properties of the CNTs. This paper analyzes the effects of defects on the CNTs electrical properties and finds a regulatory effect, providing a reference for carbon-based transistor manufacturing.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26727–26736 26727–26736"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasensitive Photoelectrochemical Biosensor for BRCA-1 Detection Based on MoS2/CdIn2S4 Heterojunctions and an FePdMnCoPt High-Entropy Alloy Nanozyme","authors":"Jia-Yan Ye,&nbsp;Jia-Lin Li,&nbsp;Yi-Hong Chen,&nbsp;Li-Ping Mei,&nbsp;Ai-Jun Wang,&nbsp;Pei Song* and Jiu-Ju Feng*,&nbsp;","doi":"10.1021/acsanm.4c0523510.1021/acsanm.4c05235","DOIUrl":"https://doi.org/10.1021/acsanm.4c05235https://doi.org/10.1021/acsanm.4c05235","url":null,"abstract":"<p >Breast cancer susceptibility protein-1 (BRCA-1) is a gene directly associated with hereditary breast cancer. BRCA-1 suppresses tumorigenesis, which is crucially involved in cell replication regulation and DNA damage repair, coupled by maintaining normal cell growth. Its accurate and straightforward analysis is essential for clinical diagnosis and treatment. In this study, we fabricated photoactive Z-schemed MoS₂/CdIn₂S₄ heterojunctions via hydrothermal synthesis and comprehensively characterized their optical properties using various techniques, with a focus on understanding the interfacial charge transfer process. At the same time, FePdMnCoPt high-entropy alloy/N-doped carbon spheres (termed FePdMnCoPt HEA/NCS) were prepared by confined adsorption and pyrolysis, and their ability to mimic peroxidase (POD)-like acitvity was investigated by oxidation of 3,3′5,5′-tetramethylbenzidine (TMB) in the presence of H₂O₂. On such basis, a MoS₂/CdIn₂S₄-based photoelectrochemical (PEC) sensor was established for the analysis of BRCA-1. The detection signal was greatly amplified by the catalytic precipitation reaction for 4-chloro-1-naphthol (4-CN) oxidation, as assisted by the FePdMnCoPt HEA/NCS nanozyme. The developed PEC sensor had a broad detection range of (0.1–1.0) × 10⁵ pg mL^–1 with a lower detection limit of 1.00 pg mL^–1. This study has developed a ultrasensitive PEC biosensor for the quantitative detection of BRCA-1, which holds great promise for clinical diagnosis.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27197–27209 27197–27209"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Driven Multidomain Nanomaterial Design: From Bibliometric Analysis to Applications","authors":"Hong Wang,&nbsp;Hengyu Cao and Liang Yang*,&nbsp;","doi":"10.1021/acsanm.4c0494010.1021/acsanm.4c04940","DOIUrl":"https://doi.org/10.1021/acsanm.4c04940https://doi.org/10.1021/acsanm.4c04940","url":null,"abstract":"<p >Machine learning (ML), as an advanced data analysis tool, simulates the learning process of the human brain, enabling the extraction of features, discovery of patterns, and making accurate predictions or decisions from complex data. In the field of nanomaterial design, the application of ML technology not only accelerates the discovery and performance optimization of nanomaterials but also promotes the innovation of materials science research methods. Bibliometrics, as a research method based on quantitative analysis, provides us with a macro perspective to observe and understand the application of ML technology in nanomaterial design by statistically analyzing various indicators in the scientific literature. This paper quantitatively analyzes the literature related to ML-driven nanomaterial design from seven dimensions, revealing the importance and necessity of ML technology in nanomaterial design. It also systematically analyzes the diversified applications of the combination of ML technology and nanomaterial technology with the design of suitable ML algorithms being key to enhancing the performance of nanomaterials. In addition, this paper discusses current challenges and future development directions, including data quality and data set construction, algorithm innovation and optimization, and the deepening of interdisciplinary cooperation. This review not only provides researchers with a macro perspective to observe the current state and development trends of the field but also provides ideas and suggestions for future research. This is of significant importance and value for promoting scientific progress in the field of nanomaterial design, fostering the in-depth development of interdisciplinary research, and accelerating the innovative application of material technologies.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26579–26600 26579–26600"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nitrogen-Rich Nanoporous Ionic Covalent Organic Framework as Iodine Adsorbent in Gaseous and Aqueous Environments","authors":"Xuhui Guan,&nbsp;Zhili Shen,&nbsp;Lei Chen,&nbsp;Chong Zhang,&nbsp;Chengguo Sun,&nbsp;Yang Du,&nbsp;Bingcheng Hu* and Chao Gao*,&nbsp;","doi":"10.1021/acsanm.4c0530710.1021/acsanm.4c05307","DOIUrl":"https://doi.org/10.1021/acsanm.4c05307https://doi.org/10.1021/acsanm.4c05307","url":null,"abstract":"<p >Adsorbents for iodine capture have shown great potential in the treatment of radioactive nuclear waste. Considering that enriched binding sites and strong binding force are efficient strategies to promote the adsorption capacity of iodine, herein we design and construct a nitrogen-rich ionic nanoporous covalent organic framework (ICOF-TG-DCA) through solvothermal synthesis. ICOF-TG-DCA has been well characterized by various techniques and exhibited long-range order with an ionic skeleton. In addition, the iodine capture of ICOF-TG-DCA was investigated in vapor phase under normal pressure at 350 K and in I₂/KI aqueous solution, which the material showed iodine vapor adsorption capacity of 5.15 g g^–1 and I₃^– adsorption capacity of 2.21 g g^–1, respectively. The results show that the presence of rich nitrogen groups together with ionic interactions is beneficial to the capture of iodine in ICOF-TG-DCA. The work demonstrates that construction of nitrogen-rich ionic covalent organic frameworks is a good strategy to achieve high iodine capture performance.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27318–27324 27318–27324"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrahedral DNA Nanostructures as Multifunctional Drug-Delivery Vehicles for Treating Non-Small Cell Lung Cancer","authors":"Sanxia Wang,&nbsp;Haohan Chen,&nbsp;Zongkang Guo,&nbsp;Mohamed Aimene Benariba,&nbsp;Maolin Li*,&nbsp;Ninghan Feng*,&nbsp;Xiaoli Wang,&nbsp;Yuting Zhang and Nandi Zhou*,&nbsp;","doi":"10.1021/acsanm.4c0505810.1021/acsanm.4c05058","DOIUrl":"https://doi.org/10.1021/acsanm.4c05058https://doi.org/10.1021/acsanm.4c05058","url":null,"abstract":"<p >Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, characterized by a relatively slow growth rate and a propensity toward distant metastases following local spread. These factors present significant challenges in both diagnosis and treatment of NSCLC, particularly for early stage NSCLC. In this study, based on the self-assembled functionalized tetrahedral DNA nanostructure (TDN), a multifunctional drug delivery system has been constructed for NSCLC adenocarcinoma cell line A549 (A549 cells) to achieve intracellular imaging and combined drug delivery. The TDN was self-assembled <i>in vitro</i> and the four vertices of TDN were functionalized with Cy5, s6 aptamer, p28 cell-penetrating peptide and siRNA, respectively. Subsequently, daunorubicin (DAU) was loaded to TDN to obtain DAU@TDN-p28-s6-siRNA through the intercalation in double-stranded DNA. While Cy5 is employed for intracellular tracking and imaging, s6 aptamer is used to target A549 cells and enrich TDN around the cells, and p28 cell-penetrating peptide can facilitate the entrance of TDN into the cells via endocytosis. Once DAU@TDN-p28-s6-siRNA is taken inside the cell, the modified siRNA can bind to the mRNA guiding the translation of ERBB3 protein and down-regulate its expression, ultimately leading to the inhibition of cell growth. Simultaneously, through the targeted delivery, DAU accurately inhibits the tumor cell activity, and thus achieving the synergy with siRNA to inhibit the growth of tumor cells. <i>In vitro</i> experiments have demonstrated that compared to the control, DAU@TDN-p28-s6-siRNA reduces the expression of ERBB3 protein by 71.27%, and reduces the viability of the target cell to 37.84%, as well as exhibits high targeting specificity. Therefore, the development of TDN assemblies provides an efficient way for diagnosis and treatment of tumor cells and has potential in the biomedical field.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27071–27079 27071–27079"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142843385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal- and Nitrogen-Codoped Carbon Nanotube Field Emitters for Low-Pressure Hydrogen Sensing","authors":"Guitao Chen,&nbsp;Haijun Luo,&nbsp;Weijin Qian*,&nbsp;Mingliang Dong,&nbsp;Weijun Huang and Changkun Dong*,&nbsp;","doi":"10.1021/acsanm.4c0528810.1021/acsanm.4c05288","DOIUrl":"https://doi.org/10.1021/acsanm.4c05288https://doi.org/10.1021/acsanm.4c05288","url":null,"abstract":"<p >Metal-doped carbon nanotubes (CNTs) have great potential in hydrogen detection because of their large specific surface areas, good catalytic activity, and numerous defect states. However, CNT-based sensing materials have the problem of insufficient hydrogen sensing responsiveness at low pressure, and the effects of different types of catalytic metals on low-pressure hydrogen sensing are still unknown. In this paper, low-pressure hydrogen sensing properties were studied by construction of Fe/Co/Ni- and nitrogen-codoped CNT cathodes, and the pressure was detected from 10^–7 to 10^–4 Pa. In addition, the hydrogen sensing mechanism was studied using first-principles simulations. The experimental results suggested that the Co–N-codoped CNT cathode exhibits the best hydrogen detection properties with a field mission current increase of 224% in 5 min. Furthermore, the FE current could increase 145% in 1 min at a pressure of 4.28 × 10^–4 Pa, promising for quick detection. The simulation revealed that the work functions of metal- and nitrogen-codoped CNTs decreased rapidly with the increase of hydrogen atoms, leading to the obvious improvement of hydrogen sensing properties. These conclusions not only bring good insights into the hydrogen sensing enhancement mechanism for metal–nitrogen-codoped CNT cathodes but also provide a promising way to develop practical cathodes for quick low-pressure hydrogen detections.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27264–27274 27264–27274"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area-Addressable ZnO Nanowire-Based Cold Cathode Transparent Flat-Panel X-ray Sources for Visual Intraoperative Radiotherapy","authors":"Song Kang,&nbsp;Guofu Zhang,&nbsp;Runze Zhan,&nbsp;Yuan Xu,&nbsp;Linghong Zhou,&nbsp;Shaozhi Deng,&nbsp;Ningsheng Xu and Jun Chen*,&nbsp;","doi":"10.1021/acsanm.4c0497910.1021/acsanm.4c04979","DOIUrl":"https://doi.org/10.1021/acsanm.4c04979https://doi.org/10.1021/acsanm.4c04979","url":null,"abstract":"<p >X-ray intraoperative radiotherapy (IORT) is an important method for treating specific tumors. Area-addressable transparent flat-panel X-ray source can achieve selective-area radiotherapy and direct optical imaging guide, which could enhance the capability of the current IORT technique and has not been reported to date. In this paper, an area-addressable transparent flat-panel X-ray source was realized using zinc oxide (ZnO) nanowire field emitter arrays (FEAs) and an indium tin oxide (ITO) transparent anode. Planar-gate ZnO nanowire FEAs were fabricated and demonstrated a good addressing performance and uniform electron emission characteristics. A maximum anode current density of 884 μA/cm² was measured at one area under gate-addressed emission conditions, and the current fluctuation was approximately 5.8% in 2.5 h. The planar-gated ZnO nanowire FEAs were applied in the transparent flat-panel X-ray source. A radiation dose rate of 5.76 mGy/s was measured at the anode surface of the flat-panel X-ray source under the application of 40 kV anode voltages. The reported X-ray source device has potential applications in advanced intraoperative radiotherapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"26988–26995 26988–26995"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Space-Confined Molecular Catalysis toward Electrocatalytic CO2 Reduction on Metal Phthalocyanine@Nitrogen-Doped Carbon Nanosheet","authors":"Hongbing Zheng,&nbsp;Haoran Wu,&nbsp;Liming Qiu,&nbsp;Mingyao Yu,&nbsp;Jiajun Zhou,&nbsp;Hui Xu,&nbsp;Chunmei Lv,&nbsp;Pengfei Tian*,&nbsp;Jitong Wang* and Licheng Ling*,&nbsp;","doi":"10.1021/acsanm.4c0528010.1021/acsanm.4c05280","DOIUrl":"https://doi.org/10.1021/acsanm.4c05280https://doi.org/10.1021/acsanm.4c05280","url":null,"abstract":"<p >Phthalocyanines have emerged as attractive materials for electrocatalytic carbon dioxide reduction. However, the challenge of finding a support that is stable while maintaining catalytic activity and loading remains elusive. Porous carbon materials are considered reliable substrates for supporting molecular catalysts. Herein, a nitrogen-rich carbon nanosheet (NiPc/NMCN) with multilayer and mesoporous structure is synthesized based on a kinetically controlled self-assembly strategy and used for phthalocyanine loading. The multilayer composite structure of NMCN guides the molecular-scale dispersion of phthalocyanine and plays a crucial role in its catalytic process. Moreover, the phthalocyanine molecules retain their metal-N₄ structure after impregnation. Therefore, the remarkable CO₂ electroreduction properties of phthalocyanine are fully demonstrated. At −0.73 V vs. RHE, NiPc/NMCN achieves the highest CO faradaic efficiency (FE_CO) of 96.0%. Meanwhile, current densities in membrane electrode module electrolyzers can reach industrial amperage levels, while the FEco remains at 60% at 880 mA cm^–2. Density functional theory (DFT) indicates that the high performance of NiPc/NMCN is attributed to the significant reduction of the CO₂RR energy barrier. Phthalocyanines restricted by the porous carbon could produce the intermediate *COOH more rapidly, determining high CO₂RR selectivity, which is confirmed by in situ (FTIR) spectroscopy. Consequently, the strategy of constructing confined multilayer mesoporous carbon structures provides an avenue for the design of efficient CO₂ reduction molecular catalysts.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27275–27286 27275–27286"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142842786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-Intercalation of Metal Ions into Ammonium Vanadate Nanostructures toward Advanced Zinc Ion Batteries","authors":"Zhuo Wang,&nbsp;Hongzhi Wang,&nbsp;Xue Bai,&nbsp;Jiabao Dong,&nbsp;Kexin Zhang,&nbsp;Ke Zhan and Bin Zhao*,&nbsp;","doi":"10.1021/acsanm.4c0510810.1021/acsanm.4c05108","DOIUrl":"https://doi.org/10.1021/acsanm.4c05108https://doi.org/10.1021/acsanm.4c05108","url":null,"abstract":"<p >Aqueous zinc ion batteries (AZIBs) featuring low cost and high safety are attracting considerable interest. More recently, ammonium vanadate, characterized by its high specific capacity, is regarded as a promising cathode material for AZIBs. However, their unstable layered structures and sluggish reaction kinetics limit their further development. To overcome these limitations, metal ions (Na⁺ and Zn²⁺) are pre-intercalated into ammonium vanadate to modify the interlayer spacing and enhance charge transfer kinetics. Additionally, the impact of different pre-intercalated ions on the structure and properties of ammonium vanadate is systematically investigated. Furthermore, we successfully synthesized ammonium vanadate cathode materials (Na_0.13(NH₄)_0.48V₂O₅·0.6H₂O, Na_0.13-NVO) featuring stable nanostructures by optimizing the pre-embedded Na⁺ content. In this case, pre-intercalated sodium ions could expand the layer spacing of ammonium vanadate (9.14 Å), reduce the electrostatic interaction of Zn²⁺ with the V–O framework, and boost the Zn²⁺ diffusion rate. Benefitting from these strengths, the Na_0.13-NVO electrode exhibits a specific capacity of 365.4 mAh g^–1 at 0.5 A g^–1, along with a good cycling stability of 98.1% capacity retention over 2000 cycles at 5 A g^–1. This work supplies further insights into designing ammonium vanadate with pre-embedded metal ions and aids the development of high-performance AZIB cathodes.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27090–27099 27090–27099"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional Ti3C2@PDA/CuO2 Nanoplatform for Synergistic Photothermal, Photodynamic and Photothermal-Enhanced Chemodynamic Antibacterial Therapy","authors":"Lianyuan Ge,&nbsp;Simin Yuan,&nbsp;Xiaohong Wang,&nbsp;Yi Li,&nbsp;Delun Chen,&nbsp;Yuanyuan Wang,&nbsp;Mingyu Wang*,&nbsp;Yang Cao* and Qiang Wu*,&nbsp;","doi":"10.1021/acsanm.4c0539910.1021/acsanm.4c05399","DOIUrl":"https://doi.org/10.1021/acsanm.4c05399https://doi.org/10.1021/acsanm.4c05399","url":null,"abstract":"<p >The escalating threat of antibiotic resistance has necessitated the development of innovative antibacterial strategies. In this study, a nanoplatform, Ti₃C₂@PDA/CuO₂, was engineered to exploit the synergistic effects of photothermal therapy (PTT), photodynamic therapy (PDT) and chemodynamic therapy (CDT) under near-infrared (NIR) light irradiation for the effective treatment of bacterial infections. Upon exposure to an 808 nm NIR laser and the application of hydrogen peroxide, the Ti₃C₂@PDA/CuO₂ nanoplatform demonstrated robust PTT, PDT and significantly photothermal-enhanced CDT activities. This multimodal therapeutic approach resulted in a pronounced antimicrobial response, as evidenced by <i>in vitro</i> assays that showed an extraordinary reduction in the viability of <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, with efficacies of 98.5% and 99.5%, respectively. Our findings contribute significant insights into the design of synergistic antibacterial strategies and offer a promising avenue for the development of advanced antimicrobial interventions.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"7 23","pages":"27387–27399 27387–27399"},"PeriodicalIF":5.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142850589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}