ACS Applied Nano Materials最新文献_第4页

IF 6 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-07-01 DOI: 10.1080/10717544.2022.2088154

引用次数: 0

Biogenic biocompatible silver nanoparticles: a promising antibacterial agent. 生物源生物相容性银纳米粒子：一种前景广阔的抗菌剂。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-08-02 DOI: 10.1080/02648725.2022.2106084

Sandip Kumar Chandraker, Ravindra Kumar

{"title":"Biogenic biocompatible silver nanoparticles: a promising antibacterial agent.","authors":"Sandip Kumar Chandraker, Ravindra Kumar","doi":"10.1080/02648725.2022.2106084","DOIUrl":"10.1080/02648725.2022.2106084","url":null,"abstract":"The biogenic synthesis of silver nanoparticles (AgNPs) are gaining attention because they are eco-friendly, non-hazardous, economical and devoid of the drawbacks of physicochemical processes. Biogenic approaches for synthesizing nanoparticles (NPs) using plant leaves, seeds, bark, stems, fruits, roots and flowers are highly cost-effective compared to other methods. Silver (Ag) has been used since ancient times, but biogenic AgNPs have only been made in the last few decades. They have been employed primarily in the food and pharmaceutical industries as antimicrobials and antioxidants. Recent studies have confirmed that many molecules present in different bacteria, including Escherichia coli, Staphylococcus aureus, Citrobacter koseri, Bacillus cereus, Salmonella typhi, Klebsipneumoniaoniae, Vibrio parahaemolyticus, Pseudomonas Aeruginosa, are bound to the AgNPs and can be inhibited using multifaceted mechanisms like AgNPs inter inside the cells, free radicals, ROS generation and modulate transduction pathways. Recent breakthroughs in nanobiotechnology-based therapeutics have opened up new possibilities for fighting microorganisms. Thus, in particular, biogenic AgNPs as powerful antibacterial agents have gained much interest. Surface charge, colloidal state, shape, concentration and size are the most critical physicochemical characteristics that determine the antibacterial potential of AgNPs. Based on this review, it can be stated that AgNPs could be made better in terms of their potency, durability, accuracy, biosecurity and compatibility.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3113-3147"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40663232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on removal of pollutants from wastewater through microbial nanobiotechnology -based solutions. 通过基于微生物纳米生物技术的解决方案去除废水中污染物的综合综述。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-08-03 DOI: 10.1080/02648725.2022.2106014

Shristi Kishore, Sumira Malik, Maulin P Shah, Jutishna Bora, Vishal Chaudhary, Lamha Kumar, Riyaz Z Sayyed, Anuj Ranjan

{"title":"A comprehensive review on removal of pollutants from wastewater through microbial nanobiotechnology -based solutions.","authors":"Shristi Kishore, Sumira Malik, Maulin P Shah, Jutishna Bora, Vishal Chaudhary, Lamha Kumar, Riyaz Z Sayyed, Anuj Ranjan","doi":"10.1080/02648725.2022.2106014","DOIUrl":"10.1080/02648725.2022.2106014","url":null,"abstract":"Increasing wastewater pollution owing to the briskly rising human population, rapid industrialization, and fast urbanization has necessitated highly efficient wastewater treatment technologies. Although several methods of wastewater treatments are in practice, expensiveness, use of noxious chemicals, generation of unsafe by-products, and longer time consumption restrain their use to a great extent. Over the last few decades, nanotechnological wastewater treatment approaches have received widespread recognition globally. Microbially fabricated nanoparticles reduce the utilization of reducing, capping, and stabilizing agents, and exhibit higher adsorptive and catalytic efficiency than chemically synthesized nanomaterials. The present review comprehensively summarizes the applications of microbial nanotechnology in the removal of a wide range of noxious wastewater pollutants. Moreover, prospects and challenges associated with the integration of nanotechnology with other biological treatment technologies including algal-membrane bioreactor, aerobic digestion, microbial fuel cells, and microbial nanofiber webs have also been briefly discussed.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3087-3112"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40582078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection. 洞察 Covid-19 中的胎盘生长因子（PlGf）/angii 轴：有害的交叉点。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-09-12 DOI: 10.1080/02648725.2022.2122291

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Thabat J Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee, Gaber El-Saber Batiha

{"title":"An insight into the placental growth factor (PlGf)/angii axis in Covid-19: a detrimental intersection.","authors":"Hayder M Al-Kuraishy, Ali I Al-Gareeb, Thabat J Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee, Gaber El-Saber Batiha","doi":"10.1080/02648725.2022.2122291","DOIUrl":"10.1080/02648725.2022.2122291","url":null,"abstract":"Coronavirus disease 2019 (Covid-19) is a recent and current infectious pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Covid-19 may lead to the development of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and extrapulmonary manifestations in severe cases. Down-regulation of angiotensin-converting enzyme (ACE2) by the SARS-CoV-2 increases the production of angiotensin II (AngII), which increases the release of pro-inflammatory cytokines and placental growth factor (PlGF). PlGF is a critical molecule involved in vasculogenesis and angiogenesis. PlGF is stimulated by AngII in different inflammatory diseases through a variety of signaling pathways. PlGF and AngII are interacted in SARS-CoV-2 infection resulting in the production of pro-inflammatory cytokines and the development of Covid-19 complications. Both AngII and PlGF are interacted and are involved in the progression of inflammatory disorders; therefore, we aimed in this review to highlight the potential role of the PlGF/AngII axis in Covid-19.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3326-3345"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33463253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapeutic strategies to induce inflection in the immune response: therapy for cancer and COVID-19. 诱导免疫反应拐点的免疫治疗策略：癌症疗法和 COVID-19。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-11-21 DOI: 10.1080/02648725.2022.2147661

Saba Hasan, Prankur Awasthi, Sumira Malik, Manish Dwivedi

{"title":"Immunotherapeutic strategies to induce inflection in the immune response: therapy for cancer and COVID-19.","authors":"Saba Hasan, Prankur Awasthi, Sumira Malik, Manish Dwivedi","doi":"10.1080/02648725.2022.2147661","DOIUrl":"10.1080/02648725.2022.2147661","url":null,"abstract":"Cancer has agonized the human race for millions of years. The present decade witnesses biological therapeutics to combat cancer effectively. Cancer Immunotherapy involves the use of therapeutics for manipulation of the immune system by immune agents like cytokines, vaccines, and transfection agents. Recently, this therapeutic approach has got vast attention due to the current pandemic COVID-19 and has been very effective. Concerning cancer, immunotherapy is based on the activation of the host's antitumor response by enhancing effector cell number and the production of soluble mediators, thereby reducing the host's suppressor mechanisms by induction of a tumour killing environment and by modulating immune checkpoints. In the present era, immunotherapies have gained traction and momentum as a pedestal of cancer treatment, improving the prognosis of many patients with a wide variety of haematological and solid malignancies. Food supplements, natural immunomodulatory drugs, and phytochemicals, with recent developments, have shown positive trends in cancer treatment by improving the immune system. The current review presents the systematic studies on major immunotherapeutics and their development for the effective treatment of cancers as well as in COVID-19. The focus of the review is to highlight comparative analytics of existing and novel immunotherapies in cancers, concerning immunomodulatory drugs and natural immunosuppressants, including immunotherapy in COVID-19 patients.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3571-3610"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40701198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional and biotechnological cues of potassium homeostasis for stress tolerance and plant development. 钾平衡对抗逆性和植物发育的功能和生物技术提示。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-12-05 DOI: 10.1080/02648725.2022.2143317

S Anil Kumar, Sirisha Kaniganti, P Hima Kumari, P Sudhakar Reddy, Prashanth Suravajhala, Suprasanna P, P B Kavi Kishor

{"title":"Functional and biotechnological cues of potassium homeostasis for stress tolerance and plant development.","authors":"S Anil Kumar, Sirisha Kaniganti, P Hima Kumari, P Sudhakar Reddy, Prashanth Suravajhala, Suprasanna P, P B Kavi Kishor","doi":"10.1080/02648725.2022.2143317","DOIUrl":"10.1080/02648725.2022.2143317","url":null,"abstract":"Potassium (K+) is indispensable for the regulation of a plethora of functions like plant metabolism, growth, development, and abiotic stress responses. K+ is associated with protein synthesis and entangled in the activation of scores of enzymes, stomatal regulation, and photosynthesis. It has multiple transporters and channels that assist in the uptake, efflux, transport within the cell as well as from soil to different tissues, and the grain filling sites. While it is implicated in ion homeostasis during salt stress, it acts as a modulator of stomatal movements during water deficit conditions. K+ is reported to abate the effects of chilling and photooxidative stresses. K+ has been found to ameliorate effectively the co-occurrence of drought and high-temperature stresses. Nutrient deficiency of K+ makes leaves necrotic, leads to diminished photosynthesis, and decreased assimilate utilization highlighting the role it plays in photosynthesis. Notably, K+ is associated with the detoxification of reactive oxygen species (ROS) when plants are exposed to diverse abiotic stress conditions. It is irrefutable now that K+ reduces the activity of NADPH oxidases and at the same time maintains electron transport activity, which helps in mitigating the oxidative stress. K+ as a macronutrient in plant growth, the role of K+ during abiotic stress and the protein phosphatases involved in K+ transport have been reviewed. This review presents a holistic view of the biological functions of K+, its uptake, translocation, signaling, and the critical roles it plays under abiotic stress conditions, plant growth, and development that are being unraveled in recent times.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3527-3570"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35254782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological insights into the multifaceted biological properties of quinic acid. 对奎宁酸多方面生物特性的药理学见解。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-09-19 DOI: 10.1080/02648725.2022.2122303

Taoufiq Benali, Saad Bakrim, Rokaia Ghchime, Nisrine Benkhaira, Nasreddine El Omari, Abdelaali Balahbib, Doaue Taha, Gökhan Zengin, Mohammad Mehedi Hasan, Shabana Bibi, Abdelhakim Bouyahya

{"title":"Pharmacological insights into the multifaceted biological properties of quinic acid.","authors":"Taoufiq Benali, Saad Bakrim, Rokaia Ghchime, Nisrine Benkhaira, Nasreddine El Omari, Abdelaali Balahbib, Doaue Taha, Gökhan Zengin, Mohammad Mehedi Hasan, Shabana Bibi, Abdelhakim Bouyahya","doi":"10.1080/02648725.2022.2122303","DOIUrl":"10.1080/02648725.2022.2122303","url":null,"abstract":"Quinic acid is a cyclohexanecarboxylic acid contained in the extracts of several parts of medicinal plants including Haematocarpus validus, Hypericum empetrifolium, Achillea pseudoaleppica, Rumex nepalensis, Phagnalon saxatile subsp. saxatile, Coffea arabica, Ziziphus lotus L, and Artemisia annua L … etc. Currently, in vitro and in vivo pharmacological studies showed that quinic acid exhibits various biological activities, such as antioxidant, antidiabetic, anticancer activity, antimicrobial, antiviral, aging, protective, anti-nociceptive and analgesic effects. Indeed, QA possesses an important antibacterial effect which could be explained by the fact that this molecule modules the functions of ribosomes and the synthesis of aminoacyl-tRNAs, modifications the levels of glycerophospholipids and fatty acids and disruption of the oxidative phosphorylation pathway thereby causing interference with membrane fluidity. The antidiabetic activity of AQ is achieved by stimulation of insulin secretion via the mobilization of Ca2+ from intracellular reserves and the increase in the NAD(P)H/NAD(P)+ ratio. Its anticancer effect is through the promotion of apoptosis, inhibition of activator protein 1 (AP-1) and signaling pathways involving protein kinase C (PKC) and certain mitogen-activated protein kinases (MAPKs), resulting in the downregulation of matrix metallopeptidase 9 (MMP-9) expression. Therefore, this review describes the main research work carried out on the biological properties of AQ and the mechanism of action underlying some of these effects, as well as the investigations of the main pharmacokinetic studies.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3408-3437"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40368621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prostaglandins and non-steroidal anti-inflammatory drugs in Covid-19. Covid-19 中的前列腺素和非甾体抗炎药。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-09-13 DOI: 10.1080/02648725.2022.2122290

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Thabat J Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee, Gaber El-Saber Batiha

{"title":"Prostaglandins and non-steroidal anti-inflammatory drugs in Covid-19.","authors":"Hayder M Al-Kuraishy, Ali I Al-Gareeb, Thabat J Al-Maiahy, Athanasios Alexiou, Nobendu Mukerjee, Gaber El-Saber Batiha","doi":"10.1080/02648725.2022.2122290","DOIUrl":"10.1080/02648725.2022.2122290","url":null,"abstract":"In response to different viral infections, including SARS-CoV-2 infection, pro-inflammatory, anti-inflammatory cytokines, and bioactive lipids are released from infected and immune cells. One of the most critical bioactive lipids is prostaglandins (PGs) which favor perseverance of inflammation leading to chronic inflammation as PGs act as cytokine amplifiers. PGs trigger the release of pro-inflammatory cytokines, activate Th cells, recruit immune cells, and increase the expression of pro-inflammatory genes. Therefore, PGs may induce acute and chronic inflammations in various inflammatory disorders and viral infections like SARS-CoV-2. PGs are mainly inhibited by non-steroidal anti-inflammatory drugs (NSAIDs) by blocking cyclooxygenase enzymes (COXs), which involve PG synthesis. NSAIDs reduce inflammation by selective or non-selective blocking activity of COX2 or COX1/2, respectively. In the Covid-19 era, there is a tremendous controversy regarding the use of NSAIDs in the management of SARS-CoV-2 infection. As well, the possible role of PGs in the pathogenesis of SARS-CoV-2 infection is not well-defined. Thus, the objective of the present study is to review the potential role of PGs and NSAIDs in Covid-19 in a narrative review regarding the preponderance of assorted views.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3305-3325"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33464244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT/CGRP pathway and Sumatriptan role in Covid-19. 5-HT/CGRP 通路和舒马曲普坦在 Covid-19 中的作用。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-08-30 DOI: 10.1080/02648725.2022.2108996

Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Nobendu Mukerjee, Sadiq Mohammed J Al-Hamash, Thabat J Al-Maiahy, Gaber El-Saber Batiha

{"title":"5-HT/CGRP pathway and Sumatriptan role in Covid-19.","authors":"Hayder M Al-Kuraishy, Ali I Al-Gareeb, Athanasios Alexiou, Nobendu Mukerjee, Sadiq Mohammed J Al-Hamash, Thabat J Al-Maiahy, Gaber El-Saber Batiha","doi":"10.1080/02648725.2022.2108996","DOIUrl":"10.1080/02648725.2022.2108996","url":null,"abstract":"Coronavirus disease 2019 (Covid-19) is a pandemic caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). In Covid-19, there is uncontrolled activation of immune cells with a massive release of pro-inflammatory cytokines and the development of cytokine storm. These inflammatory changes induce impairment of different organ functions, including the central nervous system (CNS), leading to acute brain injury and substantial changes in the neurotransmitters, including serotonin (5-HT) and calcitonin gene-related peptide (CGRP), which have immunomodulatory properties through modulation of central and peripheral immune responses. In Covid-19, 5-HT neurotransmitters and CGRP could contribute to abnormal and atypical vascular reactivity. Sumatriptan is a pre-synaptic 5-HT (5-HT1D and 5-HT1B) agonist and inhibits the release of CGRP. Both 5-HT and CGRP seem to be augmented in Covid-19 due to underlying activation of inflammatory signaling pathways and hyperinflammation. In virtue of its anti-inflammatory and antioxidant properties with inhibition release of 5-HT and CGRP, Sumatriptan may reduce Covid-19 hyperinflammation. Therefore, Sumatriptan might be a novel potential therapeutic strategy in managing Covid-19. In conclusion, Sumatriptan could be an effective therapeutic strategy in managing Covid-19 through modulation of 5-HT neurotransmitters and inhibiting CGRP.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3148-3173"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40332834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in pomegranate peel extract mediated nanoparticles for clinical and biomedical applications. 石榴皮提取物介导的纳米颗粒在临床和生物医学应用方面的最新进展。

IF 6.5 2区材料科学

ACS Applied Nano Materials Pub Date : 2024-12-01 Epub Date: 2022-09-18 DOI: 10.1080/02648725.2022.2122299

Prakash Monika, M N Chandraprabha, R Hari Krishna, Maanya Vittal, C Likhitha, N Pooja, Vishal Chaudhary, Manjunatha C

{"title":"Recent advances in pomegranate peel extract mediated nanoparticles for clinical and biomedical applications.","authors":"Prakash Monika, M N Chandraprabha, R Hari Krishna, Maanya Vittal, C Likhitha, N Pooja, Vishal Chaudhary, Manjunatha C","doi":"10.1080/02648725.2022.2122299","DOIUrl":"10.1080/02648725.2022.2122299","url":null,"abstract":"Manufacturing new materials at the nanoscale level is a field that is rapidly expanding with widespread application in advanced science and MMT is effectively used for the technology. Nanoparticles (NP), the building blocks of nanotechnology, exhibit improved properties than the larger counterparts and can be prepared from a variety of metals, including silver, copper, gold, zinc, and others. Phytonanotechnology is gaining major attention as various clinical researches have focused on the excellent properties (physicochemical and biological) of nanoscale phytochemicals and its applications in biological systems. In recent developments, pomegranate (Punica granatum L.) has gained major attention due to the phenolic compounds like apigenin, caffeic acid, chlorogenic acid, cyanidin, ellagic acid, gallic acid, granatin A, granatin B, pelargonidin, punicalagin, punicalin and quercetin found in its peel. Pomegranate Peel Extract (PPE) that aid the synthesis of PPE mediated nanoparticles (PPE-MNPs) like PPE-MAuNPs, PPE-MAgNPs, PPE-MZnONPs, PPE-MCuNPs, PPE-MPtNPs and PPE-MFeNPs has yielded plethora of beneficial properties in both plants and humans. In the current review, we discuss in detail the recent advances in synthesis and characterization of various nanoparticles from PPE. Moreover, the multitude biological properties of PPE-MNPs make up the long list of clinical uses. In addition, we discuss the pharmacokinetics, current advantages, and limitations of PPE-MNPs which can further help in development of more efficient therapeutics. Despite some of the challenges, PPE-MNPs hold a lot of potential for drug delivery and are always a better choice. The convergence of science and engineering has created new hopes, in which phytomedicines will have more efficacy, bioavailability, and less toxicity.","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":" ","pages":"3379-3407"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40366656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0