ACS Applied Nano Materials最新文献

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Enhanced Fibrous Scaffolds for Drug Delivery Applications: Core–Shell Fiber Scaffolds with Antibiotic-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0097210.1021/acsanm.5c00972
Yu Sun, Jesse Heacock, Jiangguo Liu* and Yan Vivian Li*, 
{"title":"Enhanced Fibrous Scaffolds for Drug Delivery Applications: Core–Shell Fiber Scaffolds with Antibiotic-Encapsulated Poly(lactic-co-glycolic acid) Nanoparticles","authors":"Yu Sun,&nbsp;Jesse Heacock,&nbsp;Jiangguo Liu* and Yan Vivian Li*,&nbsp;","doi":"10.1021/acsanm.5c0097210.1021/acsanm.5c00972","DOIUrl":"https://doi.org/10.1021/acsanm.5c00972https://doi.org/10.1021/acsanm.5c00972","url":null,"abstract":"<p >For the past decade, the utilization of nanoparticles (NPs) and nanofabrication techniques has dramatically advanced drug delivery systems in transdermal medication research. Among these advancements, core–shell fiber scaffolds (CSFS) incorporating drug carriers have emerged as particularly promising for the development of innovative transdermal materials due to their properties of (i) sustainable release profiles, (ii) modifiable open sites, and (iii) expensive material replacements. While existing research has predominantly focused on incorporation of inorganic NPs (metals, metal/semimetal oxides, and drug-only) into CSFS, there remains a notable gap in the literature regarding integration of polymeric NPs. In this study, a double emulsion solvent evaporation method was employed to synthesize gentamicin (Gen)-encapsulated poly(lactic acid-<i>co</i>-glycolic acid) (PLGA) NPs. These Gen/PLGA NPs were then incorporated into polyurethane (PU)/poly(ethylene oxide) (PEO) CSFS using a coaxial electrospinning technique. The resulting fibrous scaffolds were characterized to study their morphology, chemical composition, structure, release profiles, and antibacterial activity. The results indicated successful incorporation of Gen/PLGA NPs into PU/PEO CSFS. The resulting CSFS exhibited inner and outer diameters of 1.38 and 2.22 μm, respectively. Utilization of PEO in the shell spinning solution was found to effectively mitigate immiscibility between core and shell solutions while also facilitating the controlled release of gentamicin. Drug release profiles and antimicrobial tests further supported the efficacy of Gen/PLGA NPs-PU/PEO CSFS in inhibiting <i>Escherichia coli</i> growth, demonstrating sustained release of 19.02% gentamicin over 12 h. Overall, the study offers a promising strategy for (i) long-term therapeutic drug delivery with (ii) controlled release rates, (iii) effective antimicrobial activity, and (iv) stable structure against <i>E. coli</i> affections. These findings underscore the potential of this methodology for advancing the development of innovative transdermal materials.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 11","pages":"5853–5861 5853–5861"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ZnSTe/ZnSe/ZnS Reverse Type-I Blue-emitting Quantum Dot Diodes
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0027510.1021/acsanm.5c00275
Do-Hyun Kim, Taesoo Lee, Si Cheon Kim, Kyungmoon Kang, Hyo-Geun Kwon, Kihyo Kim, Heung Bae Jeon*, Jeonghun Kwak* and Sang-Wook Kim*, 
{"title":"ZnSTe/ZnSe/ZnS Reverse Type-I Blue-emitting Quantum Dot Diodes","authors":"Do-Hyun Kim,&nbsp;Taesoo Lee,&nbsp;Si Cheon Kim,&nbsp;Kyungmoon Kang,&nbsp;Hyo-Geun Kwon,&nbsp;Kihyo Kim,&nbsp;Heung Bae Jeon*,&nbsp;Jeonghun Kwak* and Sang-Wook Kim*,&nbsp;","doi":"10.1021/acsanm.5c0027510.1021/acsanm.5c00275","DOIUrl":"https://doi.org/10.1021/acsanm.5c00275https://doi.org/10.1021/acsanm.5c00275","url":null,"abstract":"<p >ZnSTe/ZnSe/ZnS core/shell/shell quantum dots (QDs) were synthesized using a single ZnS precursor to achieve blue-emitting QDs with an emission peak at 450 nm. In this structure, a small quantity of tellurium (Te) was surface-doped onto the inner-core ZnS surface positioned at the interface with the ZnSe shell. This doping suppressed the surface trap emission and induced a red-shift in the emission of the final ZnSTe/ZnSe/ZnS core/shell/shell QDs, resulting in an improved quantum yield (QY) after the application of the outer ZnS shell. These QDs exhibited a photoluminescence (PL) peak at 447 nm, a full width at half maximum (fwhm) of 35 nm, and a PL QY of 74%. The emission spectrum demonstrated excellent symmetry, with half-maxima widths of 17.3 and 18.2 nm on either side of the peak center. When incorporated into electroluminescent (EL) devices, quantum-dot light-emitting diodes displayed band–edge emission with symmetric EL spectra centered at a peak wavelength of 451 nm and a fwhm of 30 nm. These devices achieved a maximum luminance of 2200 cd/m<sup>2</sup>, an external quantum efficiency of 4.58%, and a current efficiency of 2.31 cd/A.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 11","pages":"5721–5729 5721–5729"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coating Boron Nitride Nanosheets with a Perfluoropolyether to Improve Thermal Conductivity
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0010410.1021/acsanm.5c00104
Xin Ge, Rong Chen, Jian Liu and Muchao Qu*, 
{"title":"Coating Boron Nitride Nanosheets with a Perfluoropolyether to Improve Thermal Conductivity","authors":"Xin Ge,&nbsp;Rong Chen,&nbsp;Jian Liu and Muchao Qu*,&nbsp;","doi":"10.1021/acsanm.5c0010410.1021/acsanm.5c00104","DOIUrl":"https://doi.org/10.1021/acsanm.5c00104https://doi.org/10.1021/acsanm.5c00104","url":null,"abstract":"<p >For filled-type thermally conductive composites, the interfacial compatibility between inorganic fillers and the polymer matrix plays a critical role in forming efficient thermal conduction pathways. Boron nitride nanosheets (BNNS), known for their exceptional insulating properties and high thermal conductivity, are considered one of the most promising fillers. However, their strong tendency to agglomerate and poor interfacial compatibility with polymer matrices pose significant challenges for practical applications. In this study, an amphipathic (hydrophilic–hydrophobic) oligomer, perfluoropolyether (PFPE), was employed as a surface modification agent for BNNS (referred to as FBNNS) via noncovalent functionalization. The results demonstrate that PFPE effectively reduces the surface energy of BNNS by introducing sufficient fluorine atoms, thereby enhancing its compatibility with the silicone rubber (SR) matrix. This modification significantly improves BNNS nanoparticle dispersibility within the SR matrix and reduces the interfacial thermal resistance of the BNNS/SR composite from 1.54 × 10<sup>5</sup> KW<sup>–1</sup> to 1.16 × 10<sup>5</sup> KW<sup>–1</sup>. As a result, the FBNNS/SR composite achieves a thermal conductivity of 1.97 W/m·K, reflecting a 35% improvement over the unmodified BNNS/SR composite, along with enhanced mechanical properties. This work offers valuable insights for the efficient enhancement of thermal conductivity in thermal interface materials.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"5992–6003 5992–6003"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid Detection of Brucellosis by Two-Signal Vertical Flow Immunofiltration Based on Three-Dimensional Flower-Like Au@Mn3O4 Nanozymes
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0013510.1021/acsanm.5c00135
Zhenghong Xu, Chao Tong, Tongtong Zhang, Zhihua Xu, Yu Ma, Zhihan Niu, Jiaqi Chen, Min Zhang and Feng Shi*, 
{"title":"Rapid Detection of Brucellosis by Two-Signal Vertical Flow Immunofiltration Based on Three-Dimensional Flower-Like Au@Mn3O4 Nanozymes","authors":"Zhenghong Xu,&nbsp;Chao Tong,&nbsp;Tongtong Zhang,&nbsp;Zhihua Xu,&nbsp;Yu Ma,&nbsp;Zhihan Niu,&nbsp;Jiaqi Chen,&nbsp;Min Zhang and Feng Shi*,&nbsp;","doi":"10.1021/acsanm.5c0013510.1021/acsanm.5c00135","DOIUrl":"https://doi.org/10.1021/acsanm.5c00135https://doi.org/10.1021/acsanm.5c00135","url":null,"abstract":"<p >Brucellosis, a zoonotic disease caused by the bacterium Brucella, poses a significant threat to human and animal health. Consequently, the rapid, accurate, and sensitive detection of brucellosis is essential. In this study, a three-dimensional flower-like Au@Mn<sub>3</sub>O<sub>4</sub> nanoprobe is designed and synthesized using a coprecipitation method. This nanoprobe exhibits excellent adsorption, stability, and magnetic characteristics. Considering its colorimetric signal output and oxidase-like catalytic signal amplification ability, a dual-signal vertical flow immunofiltration (VFI) test card incorporating the Au@Mn<sub>3</sub>O<sub>4</sub> nanoprobe is prepared for the rapid detection of brucellosis with high sensitivity and specificity. The serum of a brucellosis-positive patient (containing 4000 IU mL<sup>–1</sup> of Brucella antibodies) is used as a standard and diluted to detect the lowest detection limit of the Au@Mn<sub>3</sub>O<sub>4</sub> nanoprobe. For a brucellosis-positive patient, a minimum detection limit of 2 IU mL<sup>–1</sup> is achieved, although in the presence of the nanozyme, the detection limit is successfully reduced to 0.8 IU mL<sup>–1</sup>. This Au@Mn<sub>3</sub>O<sub>4</sub> nanoprobe-based VFI test card not only demonstrates a short detection time (2–3 min), but it also has the advantages of low cost, simplicity, rapidity, high sensitivity, high specificity, and high accuracy. Consequently, this system has the potential to achieve improved detection performance to meet societal needs and reduce the incidence of brucellosis through its immediate detection.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"6014–6024 6014–6024"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual-Probe SERS Chip: A Rapid and Ratiometric Detection of Trace Hg2+ in Food Samples
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0050210.1021/acsanm.5c00502
Yuqi Wan, Jingkun Li, Guoyong Jiang, Junjie Qi and Fuwei Pi*, 
{"title":"Dual-Probe SERS Chip: A Rapid and Ratiometric Detection of Trace Hg2+ in Food Samples","authors":"Yuqi Wan,&nbsp;Jingkun Li,&nbsp;Guoyong Jiang,&nbsp;Junjie Qi and Fuwei Pi*,&nbsp;","doi":"10.1021/acsanm.5c0050210.1021/acsanm.5c00502","DOIUrl":"https://doi.org/10.1021/acsanm.5c00502https://doi.org/10.1021/acsanm.5c00502","url":null,"abstract":"<p >Rapidly and accurately identifying ultratrace mercury ions (Hg<sup>2+</sup>) to protect people’s lives and health is still challenging work. A dual-probe ratiometric SERS chip was developed by growing spiderweb-like Au nanowires (AuNWs) on an AuNP array, enhancing SERS signals and selectivity for trace Hg<sup>2+</sup> detection. Due to the strong coordination ability of Hg<sup>2+</sup> to form Au-SH bonds, 4-mercaptobenzoic acid (4-MBA) was replaced by the adsorption of 4-aminothiophenol (4-ATP), thereby creating a sandwich structure (Au/Hg<sup>2+</sup>/4-ATP). Moreover, the sensor exhibits excellent anti-interference capabilities, high selectivity, and rapid detection within 3 min, with a wide linear detection range of 10<sup>–3</sup> to 10<sup>–11</sup> M and a low detection limit of 1.35 × 10<sup>–13</sup> M. It has been successfully used to detect Hg<sup>2+</sup> in fish, offering a rapid and reliable method for on-site heavy metal monitoring and mitigating mercury-related risks.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"6179–6187 6179–6187"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated Infrared Sensing Arrays Based on Ice-Templated Vertically Aligned Reduced Graphene Oxide
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0039410.1021/acsanm.5c00394
Lujie Wei, Jiali Huang, Yaqiang Ji, Shukun Lin, Yuanhong Huang, Jinglun Li, Liang Guo and Yangsu Xie*, 
{"title":"Integrated Infrared Sensing Arrays Based on Ice-Templated Vertically Aligned Reduced Graphene Oxide","authors":"Lujie Wei,&nbsp;Jiali Huang,&nbsp;Yaqiang Ji,&nbsp;Shukun Lin,&nbsp;Yuanhong Huang,&nbsp;Jinglun Li,&nbsp;Liang Guo and Yangsu Xie*,&nbsp;","doi":"10.1021/acsanm.5c0039410.1021/acsanm.5c00394","DOIUrl":"https://doi.org/10.1021/acsanm.5c00394https://doi.org/10.1021/acsanm.5c00394","url":null,"abstract":"<p >Economical, fast, and sensitive infrared (IR) sensing is essential for noncontact temperature measurement and imaging, which is crucial for a wide range of applications. In this work, we design a bolometer based on vertically aligned reduced graphene oxide (VRGO) thin films by combining oxygen-containing functional groups with vertically aligned microstructures. VRGO films feature low density (4.8–6.4 mg cm<sup>–3</sup>), ultralow thermal conductivity (1.93 mW m<sup>–1</sup> K<sup>–1</sup> in vacuum at 295 K), low resistivity (0.38 Ω·m), and moderate temperature coefficient of resistance (TCR, −0.14% K<sup>–1</sup> at 295 K), which give them greatly enhanced bolometric performance compared to graphene. The electrical and thermal transport of VRGO films from 320 to 15 K is investigated and compared with horizontally stacked RGO films. Moreover, the VRGO films exhibit high sensitivity, fast response, and good repeatability in response to radiation from a laser, blackbody radiator, and human hand. Using ice template growth and laser-assisted manufacturing, the VRGO film can be easily extended to detector arrays. The pixelated image from the 2D sensor array successfully maps the shape of the heater. Without the need for additional IR absorption and thermal isolation structures, the integrated VRGO film array can benefit lightweight and low-cost applications, such as thermal imagers in drones and wearable devices.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"6156–6167 6156–6167"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Application of Flower-like Iron Single-Atom Nanozymes for Sensitive Colorimetric Detection of Caffeic Acid
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0031510.1021/acsanm.5c00315
Ling Jiang, Yuxiu Fan, Yingying Li, Xin Li, Xiupei Yang* and Qian Zhang*, 
{"title":"Design and Application of Flower-like Iron Single-Atom Nanozymes for Sensitive Colorimetric Detection of Caffeic Acid","authors":"Ling Jiang,&nbsp;Yuxiu Fan,&nbsp;Yingying Li,&nbsp;Xin Li,&nbsp;Xiupei Yang* and Qian Zhang*,&nbsp;","doi":"10.1021/acsanm.5c0031510.1021/acsanm.5c00315","DOIUrl":"https://doi.org/10.1021/acsanm.5c00315https://doi.org/10.1021/acsanm.5c00315","url":null,"abstract":"<p >Herein we present a strategic engineering approach to develop flower-like iron single-atom nanozymes (Fe/NC-F) with exceptional catalytic performance, which are hierarchically anchored on three-dimensional carbon flower substrates fabricated from nanosheet assemblies. This innovative platform enables the construction of a sensitive and straightforward colorimetric assay for caffeic acid (CA) detection. Fe/NC-F single-atom nanozymes engineered through a template-directed synthesis protocol combined with high-temperature pyrolysis exhibit bioinspired Fe–Nx-coordinated active sites analogous to those of natural enzymes and achieve exceptional single-atom dispersion. On the basis of the exceptional peroxidase-like activity inherent in Fe/NC-F, a colorimetric sensing platform for the quantitative determination of CA was developed. This system has a broad linear working range (0.04–20 μM) with a low detection limit of 12 nM. To achieve rapid onsite detection, a CA visualization sensing platform with a linear range of 0.5–20 μM and a detection limit of 143 nM was further constructed via a smartphone app. This method was not only successfully implemented to detect CA in actual samples of coffee and blueberries but also provided a reference strategy for the design of single-atom nanozymes with high catalytic activity.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"6115–6124 6115–6124"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mercury(II) Ion Sensing through in Situ Synthesis of Gold Nanoparticles
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0017610.1021/acsanm.5c00176
Jin-Ho Park, Kyeonghyeon Nam, Young Kwan Cho, Marylyn Setsuko Arai, Dong-Hwan Kim* and Hakho Lee*, 
{"title":"Mercury(II) Ion Sensing through in Situ Synthesis of Gold Nanoparticles","authors":"Jin-Ho Park,&nbsp;Kyeonghyeon Nam,&nbsp;Young Kwan Cho,&nbsp;Marylyn Setsuko Arai,&nbsp;Dong-Hwan Kim* and Hakho Lee*,&nbsp;","doi":"10.1021/acsanm.5c0017610.1021/acsanm.5c00176","DOIUrl":"https://doi.org/10.1021/acsanm.5c00176https://doi.org/10.1021/acsanm.5c00176","url":null,"abstract":"<p >Divalent mercury ion (Hg<sup>2+</sup>) is a highly toxic substance that significantly impairs the central nervous system and genetic functions. While numerous colorimetric methods have been developed for rapid Hg<sup>2+</sup> detection in environmental samples, many existing sensing strategies involve complex processes such as nanostructure/substrate fabrication, recognizer modification, purification steps, or the use of fluorescent measurements. Here, we present a simplified one-pot Hg<sup>2+</sup> assay, termed MiDAS (mercury-induced direct AuNP synthesis), utilizing only pyruvate (Pyr) and UV light. The method establishes Hg<sup>2+</sup> sensing through <i>in situ</i> synthesis of gold nanoparticles (AuNPs). In this mechanism, Pyr selectively chelates Hg<sup>2+</sup> and functions as an effective reducing agent, converting Au<sup>3+</sup> to AuNPs and inducing significant optical changes in samples, which was corroborated by density functional theory calculations. The developed assay exhibited high specificity for Hg<sup>2+</sup> and generated quantitative signals at concentrations as low as 32 pM [Hg<sup>2+</sup>]. The potential for on-site application of MiDAS was demonstrated through the detection of spiked Hg<sup>2+</sup> in tap water, river water, and canned tuna samples.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 12","pages":"6025–6034 6025–6034"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescence Signal Amplification Based on Arginine-Glycine-Aspartate-Gold-Nanoparticle Conjugates for in Situ Monitoring of microRNAs
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.5c0105410.1021/acsanm.5c01054
Zhaoyan Zhao, Li Sun, Zhongting Wang, Yuhui Liao* and Changjun Gao*, 
{"title":"Fluorescence Signal Amplification Based on Arginine-Glycine-Aspartate-Gold-Nanoparticle Conjugates for in Situ Monitoring of microRNAs","authors":"Zhaoyan Zhao,&nbsp;Li Sun,&nbsp;Zhongting Wang,&nbsp;Yuhui Liao* and Changjun Gao*,&nbsp;","doi":"10.1021/acsanm.5c0105410.1021/acsanm.5c01054","DOIUrl":"https://doi.org/10.1021/acsanm.5c01054https://doi.org/10.1021/acsanm.5c01054","url":null,"abstract":"<p >With the rising incidence of cancer-related deaths worldwide, the highly sensitive <i>in situ</i> monitoring of tumor biomarkers is becoming increasingly crucial for the early diagnosis of cancer. For instance, fluctuations in microRNA levels may contribute to tumor inhibition or promotion, which are closely linked to the onset and progression of various cancers. In this context, we developed a one-pot synthesis strategy for arginine-glycine-aspartate (RGD)-conjugated gold nanoparticles (RGD-AuNPs). This approach generates charge-loaded, tumor-targeting nanocarriers that facilitate the intracellular transfer of a target-triggered enzyme-free amplification (TEFA) platform, enabling fluorescent signal amplification through the <i>in vivo</i> self-assembly of hairpin DNA probes. Utilizing this strategy, live-cell miRNA imaging was successfully conducted in three tumor cell lines: HepG2, A549, and MDA-MB-231. Additionally, the charge-loaded AuNP carrier proved to be an effective medium for <i>in vivo</i> TEFA. Furthermore, imaging of tumor tissues in mice demonstrated that charge-loaded AuNP carriers can be employed in a tumor-labeling strategy. These carriers were utilized to efficiently perform <i>in vivo</i> TEFA, representing a significant technical advancement in the field of live-cell native miRNA monitoring and target-triggered tumor labeling.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 11","pages":"5862–5872 5862–5872"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temperature-Dependent Fatigue Properties of MXene-Based Flexible Pressure Sensor with Hollow Structure
IF 5.3 2区 材料科学
ACS Applied Nano Materials Pub Date : 2025-03-13 DOI: 10.1021/acsanm.4c0698110.1021/acsanm.4c06981
Hai-Jiao Men, Jian-Yao Song and Jian-Chang Li*, 
{"title":"Temperature-Dependent Fatigue Properties of MXene-Based Flexible Pressure Sensor with Hollow Structure","authors":"Hai-Jiao Men,&nbsp;Jian-Yao Song and Jian-Chang Li*,&nbsp;","doi":"10.1021/acsanm.4c0698110.1021/acsanm.4c06981","DOIUrl":"https://doi.org/10.1021/acsanm.4c06981https://doi.org/10.1021/acsanm.4c06981","url":null,"abstract":"<p >The sensing capability of flexible piezoresistive sensors made of polymers and nanofillers can be significantly improved by a hollow design, with their mechanical stability being closely linked to temperature variations. In this article, a flexible piezoresistive sensor based on hollow polydimethylsiloxane (PDMS)/MXene/carbon nanotube active layers is fabricated using a sacrificial template method. It is observed that the sensitivity of the sensor is attenuated down to 8% as the temperature falls from 20 to −40 °C during bending 10,000 times. The numerical results and theoretical analysis indicate that reduced strain energy absorption by PDMS and weakened geometric confinement of the hollow skeleton at low temperatures jointly accelerate the disruption of van der Waals interactions at the PDMS/MXene interface, constituting the main cause of this phenomenon. The interfacial energy dissipation behavior of PDMS can effectively alleviate van der Waals force damage and protect the integrity of the hollow skeleton at 20 °C. However, under subzero temperatures, the PDMS chains cannot effectively disperse strain energy, and this results in damage to the hollow structure, ultimately deteriorating the sensor’s fatigue endurance. This work may provide new insights for the development of flexible electronics with antifatigue performance in harsh environments.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 11","pages":"5412–5419 5412–5419"},"PeriodicalIF":5.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143666931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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