ACS Applied Nano Materials最新文献

{"title":"Decoupling Dark Current and Photogain in Silicon-Based Graphene Architecture for Multidimensional Photodetection","authors":"Cong Li,&nbsp;Kaixi Bi,&nbsp;Guangchen Yin,&nbsp;Yaxin Zhou,&nbsp;Xinyu Liang,&nbsp;Xianze Zhou,&nbsp;Xing Cao,&nbsp;Linyu Mei","doi":"10.1021/acsanm.6c03740","DOIUrl":"https://doi.org/10.1021/acsanm.6c03740","url":null,"abstract":"<p>Silicon-graphene architecture holds significant promise in the field of wafer-level process-compatible and high-performance optoelectronic device development. Despite the fact that graphene exhibits ultrabroadband absorption, silicon-based graphene photodetectors generally present low specific detectivity (<span>⁠<span></span><math><msup><mi>D</mi><mo>*</mo></msup></math>⁠</span>) limited by the zero-bandgap nature and the poor light absorption. Different from traditional doping or metasurface design, this work systematically investigates the layer-dependent behavior of the photoresponse of non-equilibrium carriers in a back-gate-controlled Si/SiO₂/graphene architecture. In single-layer graphene, the lack of dielectric screening causes photoconductance gain to be inevitably accompanied by a sharp increase in dark current. Conversely, the strong Thomas−Fermi screening in multilayer graphene (MLG) attenuates the global electric field penetration, achieving a synergy between dark current suppression and photocurrent gain. Under 365 nm UV excitation, the MLG device achieves <span><span></span><math><msup><mi>D</mi><mo>*</mo></msup></math></span> = <span><span></span><math><mn>1.27</mn><mo>×</mo><msup><mn>10</mn><mn>10</mn></msup></math></span> Jones in the steady-state negative photoconductance mode (NPC, <span><span></span><math><msub><mi>V</mi><mrow><mi>b</mi><mi>g</mi></mrow></msub><mo>=</mo><mo>−</mo><mn>22</mn></math></span> V). In the deeply biased positive photoconductance mode (PPC, <span><span></span><math><msub><mi>V</mi><mrow><mi>b</mi><mi>g</mi></mrow></msub><mo>=</mo><mo>−</mo><mn>32</mn></math></span> V), the external quantum efficiency (EQE) and responsivity (<span>⁠<span></span><math><mi>R</mi></math>⁠</span>) are enhanced to 52.5% and 154.6 mA/W, respectively. Furthermore, the device exhibits multidimensional photodetection capabilities at room temperature, encompassing both spectral (ultraviolet to near-infrared) and intensity (weak to strong) dimensions. Enabled by the reconfigurable switching of the photoresponse polarity, the photocurrent in each wavelength band achieves an effective photocurrent enhancement factor of approximately 2 orders of magnitude compared to the zero-gate state.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 41","pages":"19416–19428"},"PeriodicalIF":5.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tannic Acid Coated with Magnesium Hydroxide and Nanoparticles of Fe-MOF for Applications as Flame Retardants and Increasing the Mechanical Durability of One-Component Polyurea Coatings","authors":"Chang Dai,&nbsp;Yifan Wang,&nbsp;Xishun Qiu,&nbsp;Jiazhao Li,&nbsp;Chao Wu,&nbsp;Jinhu Hu,&nbsp;Mingliang Ma,&nbsp;Ye-Tang Pan,&nbsp;Zhijiong Wu","doi":"10.1021/acsanm.6c03685","DOIUrl":"https://doi.org/10.1021/acsanm.6c03685","url":null,"abstract":"<p>One-component polyurea (PUA) has attracted increasing attention as a protective coating material because of its excellent adhesion, outstanding corrosion resistance, and simple application process. Nevertheless, its intrinsic flammability, rapid heat release, and excessive smoke generation during combustion greatly restrict its use in fire protection applications. In this work, a hierarchical TA-MH/Fe-MOF nanohybrid flame retardant was constructed by functionalizing magnesium hydroxide (MH) with biomass-derived tannic acid (TA), followed by the assembly of Fe-MOF nanoparticles onto the TA-functionalized MH surface. The polyphenol-rich TA layer improved the interfacial compatibility between MH and the PUA matrix. It also provided abundant coordination sites for for Fe-MOF immobilization, thereby constructing a hierarchical nanoscale interface and improving filler dispersion. The incorporation of TA-MH/Fe-MOF significantly improved the flame-retardant performance of one-component PUA. Compared with neat PUA, the limiting oxygen index (LOI) of the composite increased to 22.4%. Meanwhile, the peak heat release rate (PHRR), peak smoke production rate (PSPR), total smoke production (TSP), and peak CO₂ production (pCO₂P) decreased by 42.18%, 32.08%, 50.00%, and 42.11%, respectively. Furthermore, the residual char yield increased significantly, and a more continuous and compact carbonaceous protective layer was formed during combustion. More importantly, the hierarchical nanostructure structure improved the dispersion of the flame retardant within the one-component PUA matrix. As a result, the composite maintained excellent mechanical properties while exhibiting enhanced corrosion resistance. This study provides a simple, environmentally friendly, and efficient strategy for developing high-performance one-component PUA protective coatings.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 41","pages":"19400–19415"},"PeriodicalIF":5.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Energy-Transfer Pathways in Nd-Sensitized Er-Rich Nanostructures: The Competition between Cross-Relaxation and Phonon-Assisted Sensitization","authors":"Kefan Wu,&nbsp;Jun Yuan,&nbsp;Chixiao Miao,&nbsp;Long Shao,&nbsp;Hongfei Li,&nbsp;Yue Liu,&nbsp;Youlin Zhang,&nbsp;Langping Tu,&nbsp;Jing Zuo,&nbsp;Hong Zhang","doi":"10.1021/acsanm.6c03330","DOIUrl":"https://doi.org/10.1021/acsanm.6c03330","url":null,"abstract":"<p>Rare earth-doped upconversion nanomaterials, which convert near-infrared light into visible or ultraviolet light, are widely recognized as having a huge potential application market, which unfortunately is restricted by their obstinate insufficient luminescence efficiency. Very recently, combining the strategies of phonon regulation and rare-earth high-level doping, nearly two orders of magnitude upconversion luminescence enhancement have been reported from the Er-based cryogenic materials. However, the inherent weak absorption of Er³⁺ at 808 nm remains a barrier. On the other hand, Nd sensitization has been widely used to extend excitation to around 808 nm, but its sensitization effect at cryogenic temperatures remains largely unexplored. In this work, a well-defined Nd-sensitized strategy (i.e., employing NaErF₄@NaYbF₄@NaYF₄:30%Nd) that allows 808 nm absorption in both core and outer layer was developed to break through this limitation. By combining Nd³⁺ sensitization with cryogenic regulation, the optimized Er@Yb@Nd nanostructure achieves a 28.5-fold enhancement at room temperature and an overall 342-fold enhancement at 40 K. The observed temperature response is governed by the competition among the suppression of Er−Er cross-relaxation, the restriction of Nd → Yb transfer, and Er−Yb energy exchange. Importantly, temperature-dependent spectroscopy further reveals that the Nd-to-Yb energy transfer is strongly phonon assisted, making the sensitization pathway increasingly restricted at low temperatures. This finding uncovers the competition between cross-relaxation and phonon-assisted sensitization in Nd-sensitized Er-rich nanostructures and provides a mechanistic framework for the development of high-performance, highly doped luminescent materials.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 41","pages":"19307–19314"},"PeriodicalIF":5.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoscale Ruthenium Selenide-Mediated Photoacoustic Imaging-Guided Sonocatalytic Therapy for Hepatocellular Carcinoma","authors":"Xiulin Xiao,&nbsp;Lile Dong,&nbsp;Kai Wang","doi":"10.1021/acsanm.6c03418","DOIUrl":"https://doi.org/10.1021/acsanm.6c03418","url":null,"abstract":"<p>Hepatocellular carcinoma (HCC) is one of the most aggressive and fatal solid malignancies. It features an insidious early-stage progression, while advanced HCC lacks effective curative interventions. In this work, a ruthenium selenide (RuSe, RS) nanosonosensitizer was rationally fabricated for ultrasound (US)-activated sonocatalytic therapy for HCC treatment. Under US stimulation, the RS nanosonosensitizer triggers substantial intracellular reactive oxygen species overaccumulation, which disrupts mitochondrial membrane potential, consumes intracellular adenosine triphosphate and glutathione, and aggravates intracellular lipid peroxidation. The amplified oxidative stress further initiates and synergizes tumor cell apoptosis and ferroptosis, achieving suppression of HCC proliferation. Collectively, this study establishes a high-efficiency nanotheranostic paradigm for HCC management, which provides an avenue for accelerating the clinical translation of sonocatalytic tumor therapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 41","pages":"19340–19348"},"PeriodicalIF":5.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149188086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-Infrared Laser-Responsive Nanoplatform for Photodynamic/Photothermal/Chemodynamic Combined Therapy","authors":"Han Hu,&nbsp;Shijie Yao,&nbsp;Hao Jia,&nbsp;Xing cai,&nbsp;Qi Xu,&nbsp;Zushun Xu,&nbsp;Xiaofang Dai","doi":"10.1021/acsanm.6c03249","DOIUrl":"https://doi.org/10.1021/acsanm.6c03249","url":null,"abstract":"<p>Surgical resection remains a conventional clinical strategy for melanoma treatment, yet it still suffers from considerable clinical bottlenecks, including difficult surgical operations and unintended damage to adjacent normal tissues. Herein, a multifunctional nanoplatform, CeO₂-ICG@PDA (CeICP NPs), was constructed. In vitro experiments verified that CeICP NPs could act as both a chemodynamic therapy (CDT) inducer and an in situ oxygen-supplying unit under a hydrogen peroxide (H₂O₂) environment. Upon single 808 nm near-infrared laser irradiation (1.5 W/cm², 10 min), the nanosystem was activated, with the local temperature rapidly rising to 64.6 °C, triggering combined photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT), as well as responsive release of singlet oxygen (¹O₂) and hydroxyl radicals (^•OH). In vivo evaluations were performed on B16 tumor-bearing mice. Pharmacokinetic results demonstrated that CeICP NPs exhibited a blood half-life of 38.8 min, which was 15.5-fold longer than that of free indocyanine green (ICG). Dynamic fluorescence imaging and photothermal imaging (PTI) revealed that the fluorescence intensity at tumor sites in the CeICP group was 2.8 times higher than that of the free ICG group at 24 h post-intravenous injection, confirming the superior tumor-targeted accumulation capability of the nanosystem. Under NIR laser irradiation, the combined local thermal effect and abundant reactive oxygen species generated by CeICP-mediated PTT-PDT-CDT combined therapy achieved remarkable solid tumor suppression. This strategy is expected to break the limitations of traditional melanoma treatments and provide a theoretical reference for the development of intelligent nanomedicines.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"18729–18747"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controllable Preparation of Mesoporous MnO2 Loaded on Activated Carbon Nanofiber Membrane for Persistent Formaldehyde Removal from Indoor Air","authors":"Fan Liu,&nbsp;Hongyang Sang,&nbsp;Xianhua Zhang,&nbsp;Mengyu Yuan,&nbsp;Wanli Yue,&nbsp;Xindi Yuan,&nbsp;Yibao Zhou,&nbsp;Hui Zhang,&nbsp;Kangkang Ou,&nbsp;Tianmiao Wang,&nbsp;Xiaoyan sun,&nbsp;Weili Shao","doi":"10.1021/acsanm.6c02931","DOIUrl":"https://doi.org/10.1021/acsanm.6c02931","url":null,"abstract":"<p>Comprehensive treatment of indoor air pollution (including formaldehyde and PM2.5) using functional fiber filter materials has received increasing attention. This paper describes the preparation of a functional fiber with an adsorption-catalytic degradation performance for formaldehyde; mesoporous MnO₂ is constructed on the surface of polyacrylonitrile (PAN)-based activated carbon nanofibers (ACNF) using a redox hydrothermal method. A wet non-woven fabric/melt-blown non-woven/MnO₂@ACNF (WNF/MnO₂@ACNF/MB) composite air filter is then prepared based on this fiber membrane. Under optimal conditions (reaction temperature: 120 °C, pH: 7.0, potassium permanganate concentration: 0.03 mol L⁻¹, and reaction time: 6 h), porous coatings (pore sizes ranging from 3−40 nm) formed on the surface of ACNF, which were constructed from δ-MnO₂ nanosheets. The test results of continuous high concentration formaldehyde supply showed that ACNF membrane failed within 6 h under high humidity, while MnO₂@ACNF The formaldehyde removal efficiency of the membrane was still close to 80%. In situ infrared test results indicate clearly that formaldehyde decomposed into CO₂ and H₂O on the surface of the fibers. The WNF/MnO₂@ACNF/MB composite filter displays excellent filtration performance for particulate matter (PM), proving to be an exceptional method for producing functional filtration media for PM2.5 and formaldehyde removal from indoor air.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"18582–18594"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered Metallic MoWS2 Nanodots for Photoacoustic Imaging-Guided Photothermal Cancer Theranostics","authors":"Zhusheng Huang,&nbsp;Zhipeng Qian,&nbsp;Ran Li,&nbsp;Ying Zhang,&nbsp;Zhimin Luo","doi":"10.1021/acsanm.6c03814","DOIUrl":"https://doi.org/10.1021/acsanm.6c03814","url":null,"abstract":"<p>Ternary transition metal chalcogenides (TTMCs) have emerged as promising photothermal nanomaterials owing to their tunable electronic structures and strong light−matter interactions. However, exploiting phase engineering to tailor the optical energy-conversion properties of TTMCs for biomedical applications remains largely unexplored. Here, we report the fabrication of metallic 1T-phase MoWS₂ nanodots through dry ball milling and lithium-intercalation exfoliation of chemical vapor transport-grown 2H-phase MoWS₂ crystals. The resulting metallic MoWS₂ nanodots, containing 74.8% 1T phase, exhibit broad near-infrared absorption, good colloidal stability, acceptable cytocompatibility, and a high photothermal conversion efficiency of 22.2% under 785 nm irradiation, together with strong photoacoustic contrast. Benefiting from the metallic phase-enabled enhancement of light-to-heat conversion, metallic MoWS₂ nanodots achieve efficient photoacoustic imaging-guided photothermal ablation of tumors in vivo with favorable biosafety. Our work suggests that phase engineering can be an effective strategy for optimizing the photothermal and photoacoustic performance of TTMCs to expand their potential applications for cancer phototheranostics.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"19029–19037"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aluminum Oxide-Assisted Ga2O3 Nanostructures for Enhanced Solar-Blind Ultraviolet Photodetection","authors":"Anzhen Zhang,&nbsp;Weiwei Cao,&nbsp;Hang Cheng,&nbsp;Qiyi Wan,&nbsp;Bo Wang,&nbsp;Yonglin Bai","doi":"10.1021/acsanm.6c02946","DOIUrl":"https://doi.org/10.1021/acsanm.6c02946","url":null,"abstract":"<p>This study presents a nanostructure design strategy based on the functional integration of anodic aluminum oxide (AAO). Unlike the conventional use of AAO as a sacrificial template, it is directly retained as a functional substrate, preserving both its structural integrity and functional advantages. Using atomic layer deposition (ALD), Ga₂O₃ is deposited in three forms: thin films, nanopillar arrays, and nanopore arrays. Compared with thin-film device, the nanostructured devices exhibit significantly enhanced photoresponse. In particular, the nanopore device achieves a responsivity of 87 A/W, which is approximately 6 times higher than that of the thin-film device, together with an external quantum efficiency of 4.25 × 10⁴%, and a detectivity of 1 × 10¹⁴ Jones. The performance enhancement is mainly attributed to the following mechanisms: the retained AAO template enhances ultraviolet absorption through light scattering and localized electromagnetic field effects; Meanwhile, its high specific surface area strengthens the regulation of oxygen adsorption/desorption, thereby modulating the depletion layer and Schottky barrier, and optimizing carrier transport behavior. This work demonstrates that transforming AAO from a “sacrificial template” into a “functional structural unit” provides a simple and effective strategy for designing high-performance solar-blind ultraviolet photodetectors.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"18553–18567"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Application of Imidazole-Based Hyper-Crosslinked Polymer-Stabilized Silver Nanoclusters for Wastewater Treatment","authors":"Jinxia Yao,&nbsp;Shiting Lu,&nbsp;Shuai Liang,&nbsp;Jingxun Kong,&nbsp;Yilin Fu,&nbsp;Zihao Wang,&nbsp;Han Miao,&nbsp;Xinxin Li","doi":"10.1021/acsanm.6c03584","DOIUrl":"https://doi.org/10.1021/acsanm.6c03584","url":null,"abstract":"<p>Stabilizing metal nanoclusters in porous organic frameworks while maintaining accessible mass-transfer pathways is essential for maximizing metal-site utilization in heterogeneous catalysis. Herein, we developed a clotrimazole-derived imidazole hyper-crosslinked polymer, HCP-C, as a structurally and electronically tailored scaffold for immobilizing Ag nanoclusters. Clotrimazole serves as a multifunctional building block that combines abundant aromatic sites for hyper-crosslinking, Ag-coordinating imidazole N atoms, a polarizable N/π-electron-rich heteroaromatic environment, and bulky steric protection. By regulating the FeCl₃/DPX ratio, the pore structure and pore size distribution of HCP-C were systematically tuned, enabling a balance between Ag confinement and reactant diffusion. The optimized HCP-C framework enabled the uniform stabilization of Ag nanoclusters mainly in the range of 1−2 nm. Systematic control experiments and catalytic optimization confirmed that the activity was governed by the combined effects of Ag dispersion, Ag-site accessibility, pore-assisted mass transfer, and molecular stabilization rather than Ag loading alone. The optimized HCP-C-6-1 catalyst efficiently promoted the degradation of three representative organic pollutants, sunset yellow, phenol red, and 4-nitrophenol, at 15 °C, affording apparent rate constants of 1.567, 0.118, and 0.911 min⁻¹, respectively. It also exhibited a low activation energy of 35.985 kJ·mol⁻¹ and retained more than 99.7% sunset yellow removal after seven consecutive cycles. This work highlights clotrimazole-derived HCPs as readily accessible porous microenvironments for stabilizing and electronically regulating Ag active sites, offering a versatile platform for low-metal-consumption and energy-efficient catalytic degradation of diverse organic pollutants.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"18925–18940"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosaic Nanoparticles Based on Porcine Ferritin Induces Potent Protective Immunity in Pigs against Serotype O FMDV","authors":"Nan Cao,&nbsp;Yamei Li,&nbsp;Xinghua Chen,&nbsp;Hehai Li,&nbsp;Tianzhen Xu,&nbsp;Linxing Tian,&nbsp;Zihui Hu,&nbsp;Bo Yin,&nbsp;Feifei Diao,&nbsp;Xinxin Li,&nbsp;Xiangmin Li,&nbsp;Ping Qian","doi":"10.1021/acsanm.6c03377","DOIUrl":"https://doi.org/10.1021/acsanm.6c03377","url":null,"abstract":"<p>The serotypes and subtypes of foot-and-mouth disease virus (FMDV) are highly diverse, making the research and development of cross-protective and high-efficiency foot-and-mouth disease (FMD) vaccines increasingly urgent. In this study, we designed and constructed two mosaic nanoparticles by fusing porcine Ferritin (pFt) and Lumazine Synthase (LS) protein as nano-scaffolds with B-cell epitopes (VP1 G-H loop) from multi-lineage strains of serotype O FMDV and a conserved 3D T-cell epitope using the prokaryotic expression system. The results of mouse experiments confirmed that compared with 3D-LS-mGHs (<em>n</em> = 8), 3D-pFt-mGHs (<em>n</em> = 8) can induce stronger specific protective immune responses in mice. Subsequently, the immune protective effect of the 3D-pFt-mGHs (<em>n</em> = 3) in pigs was evaluated. The results showed that immunization with 3D-pFt-mGHs could induce cross-neutralizing antibodies against against O/BY/CHA/2010, O/TZ/CHA/2010 and O/ES/CHA/2001 strains in pigs, elicit robust cellular immune responses, and confer protection against FMDV serotype O infection in pigs. Collectively, the developed 3D-pFt-mGHs mosaic nanoparticle vaccine possesses great application potential for cross-neutralizing and control of serotype O FMDV.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"9 40","pages":"18802–18821"},"PeriodicalIF":5.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}