Chemical Society Reviews最新文献

{"title":"Diastereodivergence in catalytic asymmetric conjugate addition of carbon nucleophiles","authors":"Byungjun Kim, Hooseung Lee, Ilwoo Song and Sarah Yunmi Lee","doi":"10.1039/D4CS00485J","DOIUrl":"10.1039/D4CS00485J","url":null,"abstract":"<p >Catalytic asymmetric conjugate additions of carbon nucleophiles have emerged as a potent tool for constructing multi-stereogenic molecules with precise stereochemical control. This review explores the concept of diastereodivergence in such reactions, focusing on strategies to achieve selective access to diverse diastereomeric products upon carbon–carbon bond formation. Drawing from a rich array of examples, we delve into key approaches for controlling the stereochemical outcome of these transformations, including alteration of alkene geometry, fine-tuning of reaction parameters, synergistic catalysis, and isomerization of conjugate adducts. Additionally, we highlight the iterative strategies for conjugate additions, showcasing their potential for diastereodivergent synthesis of methyl-branched stereocenters in 1,3-relationships. By presenting a concentrated overview of this significant topic, this review aims to provide valuable insights into the design and execution of stereodivergent catalytic conjugate additions, offering new avenues for advancing stereoselective synthesis and structural diversity in organic synthesis.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 715-741"},"PeriodicalIF":40.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the photon avalanche luminescence of inorganic lanthanide-doped nanomaterials†","authors":"Marcin Szalkowski, Agata Kotulska, Magdalena Dudek, Zuzanna Korczak, Martyna Majak, Lukasz Marciniak, Malgorzata Misiak, Katarzyna Prorok, Artiom Skripka, P. James Schuck, Emory M. Chan and Artur Bednarkiewicz","doi":"10.1039/D4CS00177J","DOIUrl":"10.1039/D4CS00177J","url":null,"abstract":"<p >Photon avalanche (PA)—where the absorption of a single photon initiates a ‘chain reaction’ of additional absorption and energy transfer events within a material—is a highly nonlinear optical process that results in upconverted light emission with an exceptionally steep dependence on the illumination intensity. Over 40 years following the first demonstration of photon avalanche emission in lanthanide-doped bulk crystals, PA emission has been achieved in nanometer-scale colloidal particles. The scaling of PA to nanomaterials has resulted in significant and rapid advances, such as luminescence imaging beyond the diffraction limit of light, optical thermometry and force sensing with (sub)micron spatial resolution, and all-optical data storage and processing. In this review, we discuss the fundamental principles underpinning PA and survey the studies leading to the development of nanoscale PA. Finally, we offer a perspective on how this knowledge can be used for the development of next-generation PA nanomaterials optimized for a broad range of applications, including mid-IR imaging, luminescence thermometry, (bio)sensing, optical data processing and nanophotonics.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 983-1026"},"PeriodicalIF":40.4,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d4cs00177j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical valorization of captured CO2: recent advances and future perspectives†","authors":"Xin-Ming Hu, Hong-Qing Liang, Alonso Rosas-Hernández and Kim Daasbjerg","doi":"10.1039/D4CS00480A","DOIUrl":"10.1039/D4CS00480A","url":null,"abstract":"<p >The excessive emission of CO<small>₂</small> has led to severe climate change, prompting global concern. Capturing CO<small>₂</small> and converting it through electrochemistry into value-added products represent promising approaches to mitigating CO<small>₂</small> emissions and closing the carbon cycle. Traditionally, these two processes have been performed independently, involving multiple steps, high energy consumption, and low efficiency. Recently, the electrochemical conversion of captured CO<small>₂</small>, which integrates the capture and conversion processes (also referred to as electrochemically reactive CO<small>₂</small> capture), has garnered increasing attention. This integrated approach bypasses the energy-intensive steps involved in the traditional independent process, including CO<small>₂</small> release, purification, compression, transportation, and storage. In this review, we discuss recent advances in the electrochemical conversion of captured CO<small>₂</small>, focusing on four key aspects. First, we introduce various capture media, emphasizing the thermodynamic aspects of carbon capture and their implications for integration with electrochemical conversion. Second, we discuss product control mediated by the selection of different catalysts, highlighting the connections between the conversion of captured CO<small>₂</small> and gas-fed CO<small>₂</small>. Third, we examine the effect of reactor systems and operational conditions on the electrochemical conversion of captured CO<small>₂</small>, shedding light on performance optimization. Finally, we explore real integration systems for CO<small>₂</small> capture and electrochemical conversion, revealing the potential of this new technology for practical applications. Overall, we provide insights into the existing challenges, potential solutions, and thoughts on opportunities and future directions in the emerging field of electrochemical conversion of captured CO<small>₂</small>.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 3","pages":" 1216-1250"},"PeriodicalIF":40.4,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d4cs00480a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142797216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive carbon capture using electrochemical reactors","authors":"Marzieh Namdari, Yongwook Kim, Douglas J. D. Pimlott, Andrew M. L. Jewlal and Curtis P. Berlinguette","doi":"10.1039/D4CS00834K","DOIUrl":"10.1039/D4CS00834K","url":null,"abstract":"<p >The electrolytic upgrading of CO<small>₂</small> presents a promising strategy to mitigate global CO<small>₂</small> emissions while generating valuable carbon-based products such as carbon monoxide, formate, and ethylene. However, the adoption of industrial-scale CO<small>₂</small> electrolyzers is hindered by the high energy and capital costs associated with the purification and pressurization of captured CO<small>₂</small> prior to electrolysis. One promising solution is “reactive carbon capture,” which involves the electrolytic conversion of the eluent from CO<small>₂</small> capture units, or the “reactive carbon solution,” directly into valuable products. This approach circumvents the energy-intensive processes required for electrolyzers fed with gaseous CO<small>₂</small>. This Tutorial Review highlights recent advances for reactive carbon capture, showcasing its potential as a scalable solution for electrolyzers that upgrade CO<small>₂</small> into fuels and products.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 590-600"},"PeriodicalIF":40.4,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced systems for enhanced CO2 electroreduction","authors":"Wenfu Xie, Bingkun Li, Lu Liu, Hao Li, Mingzhu Yue, Qingman Niu, Shuyu Liang, Xiaodong Shao, Hyoyoung Lee, Jin Yong Lee, Mingfei Shao, Qiang Wang, Dermot O'Hare and Hong He","doi":"10.1039/D4CS00563E","DOIUrl":"10.1039/D4CS00563E","url":null,"abstract":"<p >Carbon dioxide (CO<small>₂</small>) electroreduction has extraordinary significance in curbing CO<small>₂</small> emissions while simultaneously producing value-added chemicals with economic and environmental benefits. In recent years, breakthroughs in designing catalysts, optimizing intrinsic activity, developing reactors, and elucidating reaction mechanisms have continuously driven the advancement of CO<small>₂</small> electroreduction. However, the industrialization of CO<small>₂</small> electroreduction remains a challenging task, with high energy consumption, high costs, limited reaction products, and restricted application scenarios being the issues that urgently need to be addressed. To accelerate the progress of CO<small>₂</small> electroreduction towards practical application, this review shifts the research focus from catalysts to aspects such as reactions and systems, aiming to improve reaction efficiency, reduce technical costs, expand the range of products, and enhance selectivity, offering readers a new perspective. In particular, innovative and specific design strategies such as CO<small>₂</small> reduction coupled with alternative oxidation, co-reduction reaction of CO<small>₂</small> and C/N/O/S-containing species, cascade systems, and integrated CO<small>₂</small> capture and reduction systems are discussed in detail. Additionally, personal views on the opportunities and future challenges of the aforementioned innovative strategies are provided, offering new insights for the future research and development of CO<small>₂</small> electroreduction.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 898-959"},"PeriodicalIF":40.4,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142763904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity","authors":"Muye Ma, Yongliang Zhang, Kanyi Pu and Wei Tang","doi":"10.1039/D4CS00679H","DOIUrl":"10.1039/D4CS00679H","url":null,"abstract":"<p >Immunotherapy has become a crucial strategy in cancer treatment, but its effectiveness is often constrained. Most cancer immunotherapies focus on stimulating T-cell-mediated immunity by driving the cancer-immunity cycle, which includes tumor antigen release, antigen presentation, T cell activation, infiltration, and tumor cell killing. However, metabolism reprogramming in the tumor microenvironment (TME) supports the viability of cancer cells and inhibits the function of immune cells within this cycle, presenting clinical challenges. The distinct metabolic needs of tumor cells and immune cells require precise and selective metabolic interventions to maximize therapeutic outcomes while minimizing adverse effects. Recent advances in nanotherapeutics offer a promising approach to target tumor metabolism reprogramming and enhance the cancer-immunity cycle through tailored metabolic modulation. In this review, we explore cutting-edge nanomaterial strategies for modulating tumor metabolism to improve therapeutic outcomes. We review the design principles of nanoplatforms for immunometabolic modulation, key metabolic pathways and their regulation, recent advances in targeting these pathways for the cancer-immunity cycle enhancement, and future prospects for next-generation metabolic nanomodulators in cancer immunotherapy. We expect that emerging immunometabolic modulatory nanotechnology will establish a new frontier in cancer immunotherapy in the near future.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 653-714"},"PeriodicalIF":40.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black phosphorus-based nanoplatforms for cancer therapy: chemistry, design, biological and therapeutic behaviors","authors":"Ashkan Bigham, Manuel Serrano-Ruiz, Maria Caporali, Ines Fasolino, Maurizio Peruzzini, Luigi Ambrosio and Maria Grazia Raucci","doi":"10.1039/D4CS00007B","DOIUrl":"10.1039/D4CS00007B","url":null,"abstract":"<p >Cancer, a significant threat to human lives, has been the target of research for several decades. Although conventional therapies have drawbacks, such as side effects, low efficacy, and weak targeting, they have been applied extensively due to a lack of effective alternatives. The emergence of nanotechnology in medicine has opened up new possibilities and offered promising solutions for cancer therapy. In recent years, 2D nanomaterials have attracted enormous attention in nanomedicine due to their large surface-to-volume ratio, photo-responsivity, excellent electrical conductivity, <em>etc.</em> Among them, black phosphorus (BP) is a 2D nanomaterial consisting of multiple layers weakly bonded together through van der Waals forces. Its distinct structure makes BP suitable for biomedical applications, such as drug/gene carriers, PTT/PDT, and imaging agents. BP has demonstrated remarkable potential since its introduction in cancer therapy in 2015, particularly due to its selective anticancer activity even without the aid of near-infrared (NIR) or anticancer drugs. The present review makes efforts to cover and discuss studies published on the anticancer activity of BP. Based on the type of cancer, the subcategories are organized to shed light on the potential of BP nanosheets and BP quantum dots (BPQDs) against breast, brain, skin, prostate, and bone cancers, and a section is devoted to other cancer types. Since extensive attention has been paid to breast cancer cells and <em>in vivo</em> models, various subsections, including mono-, dual, and triple therapeutic approaches are established for this cancer type. Furthermore, the review outlines various synthesis approaches employed to produce BP nanomaterials, providing insights into key synthesis parameters. This review provides an up-to-date platform for the potential reader to understand what has been done about BP cancer therapy based on each disease, and the conclusions and outlook cover the directions in which this approach is going to proceed in the future.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 827-897"},"PeriodicalIF":40.4,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d4cs00007b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unifying thermochemistry concepts in computational heterogeneous catalysis†","authors":"Bjarne Kreitz, Gabriel S. Gusmão, Dingqi Nai, Sushree Jagriti Sahoo, Andrew A. Peterson, David H. Bross, C. Franklin Goldsmith and Andrew J. Medford","doi":"10.1039/D4CS00768A","DOIUrl":"10.1039/D4CS00768A","url":null,"abstract":"<p >Thermophysical properties of adsorbates and gas-phase species define the free energy landscape of heterogeneously catalyzed processes and are pivotal for an atomistic understanding of the catalyst performance. These thermophysical properties, such as the free energy or the enthalpy, are typically derived from density functional theory (DFT) calculations. Enthalpies are species-interdependent properties that are only meaningful when referenced to other species. The widespread use of DFT has led to a proliferation of new energetic data in the literature and databases. However, there is a lack of consistency in how DFT data is referenced and how the associated enthalpies or free energies are stored and reported, leading to challenges in reproducing or utilizing the results of prior work. Additionally, DFT suffers from exchange–correlation errors that often require corrections to align the data with other global thermochemical networks, which are not always clearly documented or explained. In this review, we introduce a set of consistent terminology and definitions, review existing approaches, and unify the techniques using the framework of linear algebra. This set of terminology and tools facilitates the correction and alignment of energies between different data formats and sources, promoting the sharing and reuse of <em>ab initio</em> data. Standardization of thermochemistry concepts in computational heterogeneous catalysis reduces computational cost and enhances fundamental understanding of catalytic processes, which will accelerate the computational design of optimally performing catalysts.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 560-589"},"PeriodicalIF":40.4,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/cs/d4cs00768a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic tubular materials: from native tissues to a unifying view of new vascular, tracheal, gastrointestinal, oesophageal, and urinary grafts","authors":"Isabelle Martinier, Léa Trichet and Francisco M. Fernandes","doi":"10.1039/D4CS00429A","DOIUrl":"10.1039/D4CS00429A","url":null,"abstract":"<p >Repairing tubular tissues—the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system—from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials. Despite their apparent diversity, tubular tissues share extensive compositional and structural features. Here, we assess the current state of the art through a dual layer model, reducing each tissue to an inner epithelial layer and an outer muscular layer. Based on this model, we examine the current strategies developed to mimic each layer and we underline how each fabrication method stands in providing a biomimetic material for future clinical translation. The analysis provided here, addressed to materials chemists, biomaterials engineers and clinical staff alike, sets new guidelines to foster the elaboration of new biomimetic materials for effective tubular tissue repair.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 790-826"},"PeriodicalIF":40.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organic redox flow batteries in non-aqueous electrolyte solutions","authors":"Seongmo Ahn, Ariyeong Yun, Donghwi Ko, Vikram Singh, Jung Min Joo and Hye Ryung Byon","doi":"10.1039/D4CS00585F","DOIUrl":"10.1039/D4CS00585F","url":null,"abstract":"<p >Redox flow batteries (RFBs) are gaining significant attention due to the growing demand for sustainable energy storage solutions. In contrast to conventional aqueous vanadium RFBs, which have a restricted voltage range resulting from the use of water and vanadium, the utilization of redox-active organic molecules (ROMs) as active materials broadens the range of applicable liquid media to include non-aqueous electrolyte solutions. The extended voltage range of non-aqueous media, exceeding 2 V, facilitates the establishment of high-energy storage systems. Additionally, considering the higher cost of non-aqueous solvents compared to water, the objective in developing non-aqueous electrolyte solution-based organic RFBs (NRFBs) is to efficiently install these systems in a compact manner and explore unique applications distinct from those associated with aqueous RFBs, which are typically deployed for grid-scale energy storage systems. This review presents recent research progress in ROMs, electrolytes, and membranes in NRFBs. Furthermore, we address the prevailing challenges that require revolution, encompassing a narrow cell voltage range, insufficient solubility, chemical instability, and the crossover of ROMs. Through this exploration, the review contributes to the understanding of the current landscape and potential advancements in NRFB technology and encourages researchers and professionals in the energy field to explore this emerging technology as a potential solution to global environmental challenges.</p>","PeriodicalId":68,"journal":{"name":"Chemical Society Reviews","volume":" 2","pages":" 742-789"},"PeriodicalIF":40.4,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142719070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}