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{"title":"Reply to the letter-to-the-editor \"Percutaneous coronary intervention in nonagenarians\".","authors":"Matti Riihiniemi, Jarkko Piuhola, Matti Niemelä, Juhani Junttila","doi":"10.1080/14017431.2026.2744009","DOIUrl":"https://doi.org/10.1080/14017431.2026.2744009","url":null,"abstract":"","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":"61 1","pages":"2744009"},"PeriodicalIF":1.4,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicians' perspectives of palliative care quality in nursing homes: a cross-sectional study.","authors":"Tuva Sandsdalen, Reidun Hov, Harald Sanaker, Liv Skomakerstuen Ødbehr","doi":"10.1080/02813432.2026.2742320","DOIUrl":"10.1080/02813432.2026.2742320","url":null,"abstract":"<p><strong>Background: </strong>Since physicians have primary responsibility for medical treatment, their perspectives of palliative care quality in nursing homes can provide important knowledge for service evaluation and enhancement in this context. However, few studies exist that include their perspectives.</p><p><strong>Objectives: </strong>The aim was to investigate physicians' perspectives of the quality of palliative care in Norwegian nursing homes.</p><p><strong>Methods: </strong>A cross-sectional study conducted between November 2022 and December 2023, which included 77 nursing home physicians (response rate 43.5%) in Norway. Data were collected using a questionnaire comprising questions about demographic variables and perceptions of quality of care, as measured by the short form of the instrument Quality from the Patients' Perspective for Palliative Care (QPP-PC), adapted for healthcare personnel. Descriptive analyses and Wilcoxon signed rank tests were performed.</p><p><strong>Results: </strong>Nursing home physicians scored subjective importance of the care significantly higher than their perception of the quality of actual care received in the two dimensions; medical-technical competence and sociocultural atmosphere and for nine out of the 24 items and three out of seven additional symptom-specific questions. A need for improvement was identified in care areas such as symptom relief for pain, depression and anxiety, existential care, understanding patients' perspective, waiting time, individualized care, cooperation, and continuity.</p><p><strong>Conclusion: </strong>The results show that provision of high-quality palliative care in nursing homes can be challenging and that the physicians identified several areas for improvement. The results can provide direction for future quality improvement. However, the findings need to be confirmed in a larger sample.</p>","PeriodicalId":21521,"journal":{"name":"Scandinavian Journal of Primary Health Care","volume":"45 1","pages":"2742320"},"PeriodicalIF":1.9,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149114442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond stroke: atrial fibrillation and the broader burden of thromboembolic events in the population-based EpiHealth study.","authors":"Pernilla Höiby, Moncef Zarrouk, Lars Lind, Rani Basna, Marie Claire Overton, Sölve Elmståhl","doi":"10.1080/14017431.2026.2748120","DOIUrl":"10.1080/14017431.2026.2748120","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the distribution and risk of thromboembolic events (TEs) among adults with and without atrial fibrillation (AF), and to assess oral anticoagulant (OAC) use over time.</p><p><strong>Design: </strong>This population-based longitudinal cohort study included EpiHealth participants recruited between April 2011 and December 2016 and followed through linkage to Swedish health data registers from baseline until the first TE, death, or December 31, 2016.</p><p><strong>Results: </strong>At baseline, 873 of 22,616 participants (3.9%) had AF and 297 developed incident AF during follow-up. 484 participants experienced at least one TE during 70,587 person-years. Participants with AF had higher TE incidence (68 events, 5.9%; <i>p</i> < 0.001), predominantly arterial (73.5%), with 94% of arterial events involving the cerebral circulation. Approximately one quarter of TEs among participants with AF occurred outside the cerebral circulation and comprised both venous and non-cerebral arterial events. Although participants with incident AF represented less than one quarter of participants with AF, they accounted for 40% of TEs in the AF group. OAC use increased from 39.0% to 50.4%, with a shift from predominantly warfarin to direct oral anticoagulants. In time-dependent Cox regression adjusted for age, sex, and prior arterial thromboembolism, untreated AF was associated with increased thromboembolic risk compared with no AF (HR 2.53), whereas OAC use was associated with lower risk.</p><p><strong>Conclusions: </strong>AF was associated with substantially increased thromboembolic risk, predominantly arterial in nature. One in five TEs among participants with AF coincided with newly diagnosed AF, suggesting potential opportunities for earlier AF detection and timely initiation of anticoagulant treatment.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2748120"},"PeriodicalIF":1.4,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in suicide prevention: promise, peril, and clinical implications for clinical practice.","authors":"Bénédicte Nobile, Philippe Courtet","doi":"10.1080/19585969.2026.2745684","DOIUrl":"10.1080/19585969.2026.2745684","url":null,"abstract":"<p><p>The integration of Artificial Intelligence (AI) into psychiatry is progressing rapidly, with promising yet underexplored applications in suicide prevention. While most existing studies have focused on suicide risk prediction, AI could be applied more broadly across the suicide prevention continuum. This review explores AI's potential in improving the detection of suicidal ideation (SI), enhancing clinician training, and expanding patient access to psychotherapeutic support. Studies suggest that AI models may identify SI more sensitively than clinicians by detecting subtle linguistic or semantic cues. Furthermore, AI-based virtual patients have been shown to improve clinicians' confidence and accuracy in suicide risk assessments, particularly when used alongside traditional training methods. On the patient side, CBT-inspired AI tools offer scalable, on-demand support, but most remain unregulated and clinically unvalidated. Despite their perceived empathy and availability, such tools pose ethical and clinical risks. Many patients use AI tools without professional guidance, a trend clinicians often underestimate. This disconnect calls for urgent regulatory oversight and professional engagement. Without clear clinical validation, AI-based tools may evolve outside medical frameworks, exposing vulnerable individuals to preventable harm. Psychiatry must not only adapt but also lead, ensuring that innovation is harnessed responsibly to serve patients with empathy, safety, and scientific rigor.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"29 1","pages":"15-23"},"PeriodicalIF":5.1,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of xylooligosaccharide supplementation on methane emissions, rumen microbiome, and serum metabolome in lactating Jersey cows.","authors":"Xiaonan Zhou, Zhiyan Zhao, Lei Zhao, Qiyu Diao, Lifeng Dong, Xiaolong Kang","doi":"10.1080/10495398.2026.2743468","DOIUrl":"10.1080/10495398.2026.2743468","url":null,"abstract":"<p><p>Xylooligosaccharides (XOS) are recognized as effective prebiotics that can mitigate methane (CH₄) emissions. However, the specific relationship between the effects of XOS on CH₄ emissions and alterations in the ruminal microbiota and their metabolites remains unclear. To investigate the relationship between XOS and CH₄ emissions, 48 Jersey cows were randomly divided into two groups: the XOS group (group T) and the control group (group C). Group T received 25 g/d of XOS, while group C received 0 g/d of XOS added to the basal diet. Three randomly selected cows from each group, exhibiting consistent milk production and lactation stage, were analyzed for CH₄ emissions detection, 16S rRNA sequencing, and untargeted metabolomics analysis. The addition of XOS significantly reduced CH₄ emissions and increased both the number of observed species and the abundance-based coverage estimator (ACE) index of ruminal microbiota compared to group C. Sixteen differential metabolites were identified between the two groups; these differential metabolites were correlated with microbiota, including <i>Chloroflexi</i>, <i>Acidobacteriota</i>, and <i>Succiniclasticum.</i> The study suggests that XOS may regulate ruminant CH₄ emissions by influencing the microbiota, thereby providing a rationale for CH₄ control.</p>","PeriodicalId":7836,"journal":{"name":"Animal Biotechnology","volume":"38 1","pages":"2743468"},"PeriodicalIF":2.0,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13715329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure-guided pneumatic radial compression and radial artery occlusion after transradial coronary procedures: a retrospective historical cohort study.","authors":"Yuchan Hu, Chao Lv, Ting Zhou, Junlan Zhu, Chunyan Lu, Qun'er Lou","doi":"10.1080/14017431.2026.2753379","DOIUrl":"10.1080/14017431.2026.2753379","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate a pressure-measured pneumatic radial compression protocol and its association with radial artery occlusion (RAO) after transradial coronary procedures.</p><p><strong>Design: </strong>This single-center retrospective historical cohort included 514 consecutive patients treated between February and December 2025. The control group received conventional screw-type compression with clinically guided staged adjustment (<i>n</i> = 260), whereas the observation group received pneumatic compression with quantitative pressure measurement and individualized staged adjustment (<i>n</i> = 254). The primary outcome was RAO at 24 h; RAO at 7 days and other clinical outcomes were secondary outcomes.</p><p><strong>Results: </strong>The observation group had lower observed RAO rates than the control group at 24 h [2.8% (7/254) vs. 7.7% (20/260), <i>p</i> = 0.012] and 7 days [2.0% (5/254) vs. 5.4% (14/260), <i>p</i> = 0.040]. After Firth penalized logistic regression, the protocol remained associated with lower odds of RAO at 24 h (adjusted OR = 0.358, 95% CI: 0.143-0.809; <i>p</i> = 0.013). The observation group also had lower pain scores at 6 and 24 h (both <i>p</i> < 0.001), higher digital SpO₂ values at 2, 4, and 24 h (all <i>p</i> < 0.001), higher primary hemostatic success [97.2% vs. 93.5%, <i>p</i> = 0.042], and fewer patients with puncture-site oozing [2.8% vs. 6.9%, <i>p</i> = 0.028] or at least one local complication [11.4% vs. 28.1%, <i>p</i> < 0.001].</p><p><strong>Conclusions: </strong>Pressure-guided pneumatic compression was associated with lower observed RAO rates and more favorable hemostatic and local outcomes than conventional screw-type compression.</p><p><strong>Study registration: </strong>This study was a retrospective cohort study and did not involve a prospective intervention; therefore, clinical trial registration was not required.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2753379"},"PeriodicalIF":1.4,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149272873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulatory arrest versus aortic cross-clamping in proximal thoracic aortic aneurysm repair.","authors":"Erik Braatz, Malin Stenman, Julia Al-Mousli, Magnus Dalén, Christian Olsson","doi":"10.1080/14017431.2026.2745873","DOIUrl":"10.1080/14017431.2026.2745873","url":null,"abstract":"<p><strong>Introduction: </strong>Aortic cross‑clamping and mild hypothermic circulatory arrest (MHCA) are commonly used strategies in proximal thoracic aortic aneurysm surgery. This study compared these approaches in elective procedures for patients with a distal ascending aortic diameter of 40-50 mm. The primary outcome was a composite of 30‑day mortality, stroke, or acute kidney injury, with secondary outcomes including long‑term survival and postoperative complications.</p><p><strong>Material and methods: </strong>This single‑center observational cohort included patients treated between 2016 and 2024. Distal ascending aortic diameters were assessed on preoperative computed tomography, and clinical data were obtained from SWEDEHEART. Patients were assigned to aortic cross‑clamp (<i>n</i> = 261) or MHCA (<i>n</i> = 138). Propensity score matching was performed in a 1:1 ratio to balance baseline characteristics.</p><p><strong>Results: </strong>The composite primary outcome occurred in 15 patients (3.8%) and was more common with MHCA than with cross‑clamp (6.5% vs 2.3%, <i>p</i> = 0.035). Two patients (0.5%), both in the MHCA group, died within 30 days. After matching, the odds ratio for the composite endpoint was 2.4 (95% CI, 0.66-11.5), indicating no significant difference. Long‑term survival was similar between groups (log‑rank <i>p</i> = 0.33).</p><p><strong>Conclusions: </strong>Both strategies were associated with low perioperative risk and comparable long‑term survival. These results support flexible operative planning, allowing the distal anastomotic technique to be chosen based on individual anatomy and surgical preference.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2745873"},"PeriodicalIF":1.4,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative infections after cardiac surgery with cardiopulmonary bypass - incidence, performance of diagnostic procedures, and predictive factors.","authors":"Clara Erixon, Emilia Johannesson, Alain Dardashti, Lisa Melhammar, Johan Nilsson, Louise Thelaus, Adam Linder, Igor Zindovic","doi":"10.1080/14017431.2026.2745880","DOIUrl":"10.1080/14017431.2026.2745880","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiac surgery using cardiopulmonary bypass (CPB) induces a systemic inflammatory response that affects common inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and body temperature, complicating postoperative diagnosis of infections. The objective of this study was to assess the incidence of postoperative infections and evaluate the performance of clinically used biomarkers.</p><p><strong>Design: </strong>This was a bidirectional cohort study including patients undergoing cardiac surgery with CPB between 1st of February 2020 and 22nd of September 2021. Patients with postoperative infection were compared to patients without. Multivariable logistic regression was used to identify independent predictors of postoperative infections. Receiver operating characteristic (ROC) curves evaluated the diagnostic ability of current biomarkers to detect infection.</p><p><strong>Results: </strong>A total of 1,222 patients were included. The incidence of postoperative infections (during hospitalisation and/or late infection) was 17.3%. Patients with postoperative infection had more comorbidities, underwent more complex procedures, and had higher mortality (90-day mortality 3.8% vs 1.5%, <i>p</i> = 0.045; 1-year mortality 5.7% vs 2.7%, <i>p</i> = 0.032). CRP, WBC, and temperature performed poorly in detecting postoperative infection, although peak CRP (OR 1.069, <i>p</i> < 0.001) and peak temperature (OR 2.408, <i>p</i> = 0.005) were independent predictors of postoperative infection. Peak temperature occurred on postoperative day 5 in infected patients versus day 2 in those without infection.</p><p><strong>Conclusion: </strong>Postoperative infections following cardiac surgery with CPB remain common and are associated with increased postoperative complications and mortality. Common inflammatory biomarkers perform poorly in detecting infection. Improved diagnostic tools are needed to facilitate early detection and treatment.</p>","PeriodicalId":21383,"journal":{"name":"Scandinavian Cardiovascular Journal","volume":" ","pages":"2745880"},"PeriodicalIF":1.4,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.","authors":"Yuxuan Chen, Meimei Zhao, Xue Cao, Gao Zhou, Yu Zhang","doi":"10.1080/19585969.2026.2744744","DOIUrl":"10.1080/19585969.2026.2744744","url":null,"abstract":"<p><p>Based on a synthesis of recent advances, this review elucidates the distinct yet synergistic roles of non-rapid eye movement (NREM) and rapid eye movement (REM) sleep in memory consolidation. During NREM sleep, cortical slow oscillations (SOs) establish a temporal framework by alternating between UP and DOWN states, facilitating cross-regional communication. SOs phase-couple with thalamic spindles to coordinate hippocampal sharp-wave ripples (SWRs), thereby driving the reactivation and transfer of labile hippocampal memories to neocortical networks for long-term storage. Concurrent synaptic homeostasis optimises network efficiency through global downscaling while selectively strengthening memory-relevant connections. In REM sleep, theta oscillations synchronise limbic-prefrontal-hippocampal circuits, and ponto-geniculo-occipital (PGO) waves further integrate emotional and procedural memories. The cholinergically dominant, monoamine-depleted neurochemical milieu of REM sleep promotes dendritic spine remodelling and sparse neuronal reactivation, enabling affective decoupling and synaptic refinement. Despite progress, key challenges remain in understanding cross-frequency oscillatory coupling among slow oscillations, spindles, ripples and REM-specific rhythms, glial contributions and clinical translation. Future integration of high-density electrophysiology with computational approaches may yield mechanistic models and clinically relevant biomarkers for sleep-based cognitive monitoring and intervention.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"29 1","pages":"32-56"},"PeriodicalIF":5.1,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13674668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Animal protein supply, cognitive ageing and female-male dementia disparities: a global ecological analysis.","authors":"Wenpeng You, Bashir Sumar, Gihane Endrawes, Luisa Garcia, Shuhuan Feng, Ashlyn Sahay, Maciej Henneberg","doi":"10.1080/20565623.2026.2757078","DOIUrl":"https://doi.org/10.1080/20565623.2026.2757078","url":null,"abstract":"<p><p><b>Aim:</b> Population-level evidence linking animal protein supply with dementia incidence remains limited. This study examined global associations between national animal protein supply and dementia incidence within an ecological framework of nutritional and epidemiological transition.<b>Materials & methods:</b> Harmonized population-level data from the Food and Agriculture Organization of the United Nations statistical database (FAOSTAT), the Institute for Health Metrics and Evaluation (IHME), the World Bank, the World Health Organization (WHO) and United Nations data platforms were analyzed for up to 204 populations. Animal protein supply was examined in relation to total dementia incidence and female-male differences in dementia incidence using correlation analysis, partial correlation, polynomial modeling, principal component analysis, multivariable regression and stratified analyses by income, development and regional groupings.<b>Results:</b> Animal protein supply was positively associated with total dementia incidence. Associations were non-linear, with steeper increases at low-to-moderate supply levels and attenuation at the highest levels. Associations were stronger in low- and middle-income and developing settings than in high-income or developed contexts. Animal protein supply remained positively associated with female-male incidence differences after adjustment; independence from total incidence and mediation through it were not directly tested.<b>Conclusion:</b> Animal protein supply may operate as an ecological marker of nutritional and epidemiological transition rather than as an isolated dietary exposure. These findings support context-sensitive interpretation of diet-dementia associations in global cognitive ageing research.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"13 1","pages":"2757078"},"PeriodicalIF":2.5,"publicationDate":"2027-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149320235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}