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Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study. Authors' reply. 肺部超声评分在 COVID-19 环境中的应用和内部验证:ECOVITA 观察性研究。作者回复。
IF 10.4 2区 医学
Pulmonology Pub Date : 2025-12-31 Epub Date: 2024-10-24 DOI: 10.1016/j.pulmoe.2024.06.004
L Rinaldi, F Perrotta
{"title":"Application and internal validation of lung ultrasound score in COVID-19 setting: The ECOVITA observational study. Authors' reply.","authors":"L Rinaldi, F Perrotta","doi":"10.1016/j.pulmoe.2024.06.004","DOIUrl":"10.1016/j.pulmoe.2024.06.004","url":null,"abstract":"","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":" ","pages":"2416781"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hip Adduction and Abduction Strength Reference Values of Gaelic Football and Rugby Union Players: A Cross-Sectional Study. 盖尔足球和橄榄球联盟球员髋内收外展力量参考值:一项横断面研究。
IF 3.5 2区 医学
International journal of sports physiology and performance Pub Date : 2025-12-31 Print Date: 2025-02-01 DOI: 10.1123/ijspp.2024-0116
Ciaran O'Connor, Martin McIntyre, Eamonn Delahunt, Kristian Thorborg
{"title":"Hip Adduction and Abduction Strength Reference Values of Gaelic Football and Rugby Union Players: A Cross-Sectional Study.","authors":"Ciaran O'Connor, Martin McIntyre, Eamonn Delahunt, Kristian Thorborg","doi":"10.1123/ijspp.2024-0116","DOIUrl":"10.1123/ijspp.2024-0116","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this research was to report isometric hip adduction and abduction strength reference values of men's and women's Gaelic football and rugby union players and compare values between sexes and between sports.</p><p><strong>Methods: </strong>This cross-sectional cohort study consisted of 331 club-level athletes. Maximum isometric hip adduction squeeze and abduction press strength values were measured with a ForceFrame across several testing positions.</p><p><strong>Results: </strong>Hip adduction squeeze and abduction press strength reference values for men's and women's Gaelic and rugby union footballers were provided with mean and 1 SD. A 2-way analysis of variance demonstrated significant sport × sex interaction main effects for hip adduction squeeze (η2 = .159-.228), abduction press (η2 = .099-.144), and adduction:abduction ratio (η2 = .120). Men demonstrated significantly greater relative (Newtons per kilogram) maximum isometric hip adduction squeeze (15.5%-26.4%, 0.48-1.00 N/kg) and hip abduction press (9.6%-19.6%, 0.20-0.67 N/kg) strength across all testing positions when compared with women of the same sport. Male Gaelic football players demonstrated significantly greater hip adduction (8.7%-14.0%, 0.30-0.52 N/kg) and abduction (6.1%-8.6%, 0.16-0.31 N/kg) strength (Newtons per kilogram) than their rugby counterparts, while no significant between-sports differences in strength were observed between female athletes.</p><p><strong>Conclusion: </strong>Reference values are provided with mean and 1 SD. Sport and sex interaction had significant main effects for hip adduction, abduction, and adduction:abduction ratio, with medium to large effect sizes. Male athletes demonstrate significantly greater hip strength than female athletes of the same sport, and male Gaelic players demonstrate greater hip strength than male rugby players.</p>","PeriodicalId":14295,"journal":{"name":"International journal of sports physiology and performance","volume":" ","pages":"282-291"},"PeriodicalIF":3.5,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based survey. 葡萄牙成人哮喘患病率- epi -哮喘研究,一项全国性人群调查。
IF 10.4 2区 医学
Pulmonology Pub Date : 2025-12-31 Epub Date: 2025-03-17 DOI: 10.1080/25310429.2025.2466920
Dinis Brito, Cristina Jácome, Cláudia Bulhões, Maria João Barbosa, Nuno Pina, Ana Alves da Silva, Catarina João, Diana Gomes, Filipa Lopes, Janete Quelhas-Santos, Liliana Amorim, Marina Rodrigues, Marisa Pardal, Pedro M Teixeira, Tiago Jacinto, Ana Margarida Cruz, Ana Margarida Pereira, Ana Marques, Bernardo Sousa-Pinto, Cláudia Vicente, Elisete Ferreira, Luís Alves, Maria Inês Fernandes, Rafael Vieira, Rita Amaral, Rita Sousa, Rui Costa, Teresa Castanho, Filipa Bernardo, Jaime Correia-de-Sousa, João A Fonseca
{"title":"Prevalence of asthma in Portuguese adults - the EPI-ASTHMA study, a nationwide population-based survey.","authors":"Dinis Brito, Cristina Jácome, Cláudia Bulhões, Maria João Barbosa, Nuno Pina, Ana Alves da Silva, Catarina João, Diana Gomes, Filipa Lopes, Janete Quelhas-Santos, Liliana Amorim, Marina Rodrigues, Marisa Pardal, Pedro M Teixeira, Tiago Jacinto, Ana Margarida Cruz, Ana Margarida Pereira, Ana Marques, Bernardo Sousa-Pinto, Cláudia Vicente, Elisete Ferreira, Luís Alves, Maria Inês Fernandes, Rafael Vieira, Rita Amaral, Rita Sousa, Rui Costa, Teresa Castanho, Filipa Bernardo, Jaime Correia-de-Sousa, João A Fonseca","doi":"10.1080/25310429.2025.2466920","DOIUrl":"https://doi.org/10.1080/25310429.2025.2466920","url":null,"abstract":"<p><strong>Introduction: </strong>In 2010, 6.8% of the Portuguese adults had asthma. Contemporary studies employing more accurate methods are needed. We aimed to assess asthma prevalence in Portugal and to identify associated-factors.</p><p><strong>Methods: </strong>A population-based nationwide study was conducted from May 2021 to March 2024. A multistage random sampling approach was applied to select adults from primary care. Stage 1 involved a telephone screening interview to collect socio-demographic and clinical data. Patients with an Adult Asthma Score (A2 Score) ≥1 were eligible for Stage 2, and 5% of those with an A2 Score = 0 were also invited to participate in Stage 2, which consisted of a diagnostic visit with a physical examination and diagnostic tests. We computed weighted asthma prevalence estimates and multivariable logistic regression models were used.</p><p><strong>Results: </strong>A total of 7,556 participants completed Stage 1 and 1,857 Stage 2. The prevalence of asthma was 7.1% (95%CI = 6.3-8.0%), with slight differences by sex, age, and region. Education, family history of asthma, inhaler prescription, nasal/ocular symptoms, food allergies, and previous allergy skin tests were associated with an increased risk of asthma (R<sup>2</sup> = 33%). Asthma diagnosis could also be predicted by the A2 score, either on its own (R<sup>2</sup> = 43%) or in combination with family history and previous allergy skin tests (R<sup>2</sup> = 45%).</p><p><strong>Discussion: </strong>Asthma affects 7.1% of Portuguese adults. Family history of asthma, nasal/ocular symptoms, and comorbid food allergy are associated with increased risk of asthma.</p>","PeriodicalId":54237,"journal":{"name":"Pulmonology","volume":"31 1","pages":"2466920"},"PeriodicalIF":10.4,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking Trust and Public Health Compliance: Introducing a Trust Continuum for Policy and Practice. 重新思考信任和公共卫生合规:为政策和实践引入信任连续体。
Health systems and reform Pub Date : 2025-12-31 Epub Date: 2025-02-11 DOI: 10.1080/23288604.2025.2457239
Ashley Fox, Victoria Y Fan, Heeun Kim, Minah Kang
{"title":"Rethinking Trust and Public Health Compliance: Introducing a Trust Continuum for Policy and Practice.","authors":"Ashley Fox, Victoria Y Fan, Heeun Kim, Minah Kang","doi":"10.1080/23288604.2025.2457239","DOIUrl":"https://doi.org/10.1080/23288604.2025.2457239","url":null,"abstract":"<p><p>Trust in government has emerged as one of the strongest predictors of national performance in fighting COVID-19. This commentary aims to take stock of the vast literature on trust and compliance with public health measures that has emerged during the pandemic to synthesize policy-relevant recommendations about: 1) How to conceptualize trust; 2) Whether trust is always deserved; and 3) How governments can earn (appropriate levels of) trust. Based on a critical reading of the literature, we develop a framework that conceptualizes trust as falling along a continuum ranging from extreme distrust to blind trust with the ideal point- \"informed\" or \"basic\" trust-falling in the mid-point of the continuum. We illustrate the continuum with examples and provide recommendations regarding how governments can build more nuanced disease responses that account for individuals and sub-groups at different rungs on the continuum while (re)building trust. We conclude that trust-building is a long-term project that must continue in non-crisis times.</p>","PeriodicalId":73218,"journal":{"name":"Health systems and reform","volume":"11 1","pages":"2457239"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary health-care practices for deaf children should include early incorporation of a signed language. 聋哑儿童的初级保健措施应包括尽早使用手语。
IF 98.4 1区 医学
The Lancet Pub Date : 2025-12-21 Epub Date: 2024-08-28 DOI: 10.1016/S0140-6736(24)01564-2
Wyatte C Hall, Julia L Hecht
{"title":"Primary health-care practices for deaf children should include early incorporation of a signed language.","authors":"Wyatte C Hall, Julia L Hecht","doi":"10.1016/S0140-6736(24)01564-2","DOIUrl":"10.1016/S0140-6736(24)01564-2","url":null,"abstract":"","PeriodicalId":18014,"journal":{"name":"The Lancet","volume":" ","pages":"2498-2500"},"PeriodicalIF":98.4,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis of the efficacy of different blue light therapy methods for neonatal jaundice. 不同蓝光疗法对新生儿黄疸疗效的 Meta 分析。
IF 1.7 4区 医学
Journal of Maternal-Fetal & Neonatal Medicine Pub Date : 2025-12-01 Epub Date: 2024-11-25 DOI: 10.1080/14767058.2024.2430649
Ruoya Wu, Lingling Wen
{"title":"Meta-analysis of the efficacy of different blue light therapy methods for neonatal jaundice.","authors":"Ruoya Wu, Lingling Wen","doi":"10.1080/14767058.2024.2430649","DOIUrl":"https://doi.org/10.1080/14767058.2024.2430649","url":null,"abstract":"<p><strong>Objective: </strong>To analyze and evaluate the efficacy of different blue light therapy methods and provide evidence-based recommendations for their selection in clinical practice.</p><p><strong>Methods: </strong>Clinical randomized controlled trials (RCTs) evaluating the efficacy of various blue light therapy methods for neonatal jaundice were retrieved from both domestic and international databases. The search period covered the inception of each database until November 2023. After screening, the quality of the included studies was assessed using the Cochrane Risk of Bias tool. Literature management was conducted with NoteExpress 3.2, while data collection and extraction were performed using Excel 2003. Statistical analysis was carried out using RevMan 5.4.1. Heterogeneity was assessed using the <i>Q</i> test (<i>p</i> value), and the OR value of the combined effect was calculated using either a fixed-effects or random effects model, depending on the presence of heterogeneity. A forest plot was generated to visualize the results. Sensitivity analysis was performed by excluding the largest-weighted study, and the potential for bias in outcome indicators was assessed using a funnel plot.</p><p><strong>Results: </strong>A total of 652 articles were retrieved, with 16 clinical RCTs meeting the inclusion criteria. The meta-analysis results indicated that, compared to continuous blue light therapy in the control group, intermittent blue light therapy achieved a higher total effective rate (OR = 1.82, 95%CI (1.25-2.64), <i>p</i> = .002), significantly lower serum bilirubin levels post-treatment (OR = -14.59, 95%CI (-26.11 to -3.08), <i>p</i> = .01), and a shorter time to jaundice resolution (OR = -2.35, 95%CI (-3.83 to -0.87), <i>p</i> = .002). Additionally, the incidence of adverse reactions was lower in the intermittent therapy group compared to the control group (OR = 0.27, 95%CI (0.19-0.36), <i>p</i> < .00001). Sensitivity analysis confirmed that the combined effect size was stable and reliable (OR (95%CI) = -16.23 (-28.67 to -3.79), <i>p</i> = .01). The funnel plot suggested potential publication bias.</p><p><strong>Conclusions: </strong>Intermittent blue light therapy is effective and demonstrates significant clinical benefits, making it a valuable treatment option for neonatal jaundice in clinical practice.</p>","PeriodicalId":50146,"journal":{"name":"Journal of Maternal-Fetal & Neonatal Medicine","volume":"38 1","pages":"2430649"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of spatial and temporal aggregation of influenza cases in Quzhou before and after COVID-19 pandemic. 新冠肺炎大流行前后衢州市流感病例时空聚集分析
Annals of medicine Pub Date : 2025-12-01 Epub Date: 2024-12-23 DOI: 10.1080/07853890.2024.2443565
Qing Gao, Hui Yang, Zhao Yu, Qi Wang, Shuangqing Wang, Bingdong Zhan
{"title":"Analysis of spatial and temporal aggregation of influenza cases in Quzhou before and after COVID-19 pandemic.","authors":"Qing Gao, Hui Yang, Zhao Yu, Qi Wang, Shuangqing Wang, Bingdong Zhan","doi":"10.1080/07853890.2024.2443565","DOIUrl":"https://doi.org/10.1080/07853890.2024.2443565","url":null,"abstract":"<p><strong>Background: </strong>The global seasonal influenza activity has decreased during the coronavirus disease 2019 (COVID-19) pandemic. Non-pharmaceutical interventions (NPIs), such as reducing gatherings and wearing masks, can have varying impacts on the spread of influenza. We aim to analyse the basic characteristics, epidemiology and space-time clustering of influenza in Quzhou city before and after the COVID-19 pandemic based on five years of surveillance data.</p><p><strong>Methods: </strong>Influenza case incidence data from 2018-2023 were collected and organized in Quzhou City to analyse the space-time aggregation of influenza incidence before and after COVID-19 pandemic through global spatial autocorrelation analysis and space-time scan analysis methods.</p><p><strong>Results: </strong>The annual average fluctuation of influenza in Quzhou City from 2018-2023 was large, with gradual decreases in 2019-2020, 2020-2021 and 2021-2022, all of which showed obvious winter and spring peaks; The highest incidence rate in 2022-2023, with a bimodal distribution. The majority of the population is under 15 years of age, accounting for more than 70% of the population. The population classification is dominated by students, nursery children and children in the diaspora. In 2020-2021, the cases in the student group of the 5-14 years old population declined. Global spatial autocorrelation analysis of influenza incidence rate in Quzhou City in each year of 2019-2023Moran's <i>I</i> > 0 and <i>p</i> < 0.05. Space-time scan analysis of the aggregation area is located in Longyou County and the township streets on the border of urban counties, and the number of aggregation areas decreased significantly in 2020-2021 and 2021-2022.</p><p><strong>Conclusion: </strong>The COVID-19 pandemic has an important impact on changes in influenza incidence levels and spatial and temporal epidemiologic aggregation patterns. Influenza incidence in Quzhou City fluctuates widely, with large changes in the age and occupational composition ratios of the incidence population, and influenza incidence presents a more pronounced spatial correlation and aggregation.</p>","PeriodicalId":93874,"journal":{"name":"Annals of medicine","volume":"57 1","pages":"2443565"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research trends and key contributors in studies on influenza vaccines for children: A 20-year bibliometric analysis. 儿童流感疫苗研究的研究趋势和主要贡献者:20年文献计量分析。
IF 4.1 4区 医学
Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2024-12-20 DOI: 10.1080/21645515.2024.2443281
Ning Sun, Rui Wei, Bochao Jia, Taiwei Lou, Zirong Li, Xiaowei Nie, Wenxiao Yu, Miaoran Wang, Qiuyan Li
{"title":"Research trends and key contributors in studies on influenza vaccines for children: A 20-year bibliometric analysis.","authors":"Ning Sun, Rui Wei, Bochao Jia, Taiwei Lou, Zirong Li, Xiaowei Nie, Wenxiao Yu, Miaoran Wang, Qiuyan Li","doi":"10.1080/21645515.2024.2443281","DOIUrl":"https://doi.org/10.1080/21645515.2024.2443281","url":null,"abstract":"<p><p>Globally, there are over 3 million severe cases of influenza each year, leading to up to half a million deaths. This study provides a comprehensive analysis of the current status of children's influenza vaccine research over the past 20 years and explores potential future research trends, including improvements in vaccine coverage and strategies to address vaccine hesitancy. We extracted all research data on children's influenza vaccines from 2004 to 2024 using the Web of Science Core Collection (WOSCC). The contributions of various countries/regions, institutions, authors, and journals in this field were assessed, and research hotspots as well as promising future trends were predicted through keyword analysis using CiteSpace and VOSviewer. A total of 2,598 related publications from 2004 to 2024 were identified and collected for analysis. The United States (USA) and England emerged as the leading contributors with the highest number of published papers. AstraZeneca was identified as a key leader among research institutions, and Ambrose Christopher S was recognized as the most productive author in this field. The journals <i>Vaccine</i> and <i>Human Vaccines & Immunotherapeutics</i> stood out as the most prominent publications in this area. The keyword analysis highlighted that international research collaboration maybe a promising strategy for bridging global gaps; Addressing vaccine hesitancy could potentially increase vaccination coverage; Live attenuated vaccines, intranasal administration and universal vaccines are promising directions for future development. These insights highlight potential avenues for improving influenza vaccine coverage and inform strategies to mitigate vaccine hesitancy, crucial for protecting children and enhancing public health.</p>","PeriodicalId":49067,"journal":{"name":"Human Vaccines & Immunotherapeutics","volume":"21 1","pages":"2443281"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting oxidative stress in preeclampsia. 靶向氧化应激在子痫前期。
IF 1.5 4区 医学
Hypertension in Pregnancy Pub Date : 2025-12-01 Epub Date: 2024-12-27 DOI: 10.1080/10641955.2024.2445556
Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements
{"title":"Targeting oxidative stress in preeclampsia.","authors":"Dinara Afrose, Sofía Alfonso-Sánchez, Lana McClements","doi":"10.1080/10641955.2024.2445556","DOIUrl":"10.1080/10641955.2024.2445556","url":null,"abstract":"<p><p>Preeclampsia is a complex condition characterized by elevated blood pressure and organ damage involving kidneys or liver, resulting in significant morbidity and mortality for both the mother and the fetus. Increasing evidence suggests that oxidative stress, often caused by mitochondrial dysfunction within fetal trophoblast cells may play a major role in the development and progression of preeclampsia. Oxidative stress occurs as a result of an imbalance between the production of reactive oxygen species (ROS) and the capacity of antioxidant defenses, which can lead to placental cellular damage and endothelial cell dysfunction. Targeting oxidative stress appears to be a promising therapeutic approach that has the potential to improve both short- and long-term maternal and fetal outcomes, thus reducing the global burden of preeclampsia. The purpose of this review is to provide a comprehensive account of the mechanisms of oxidative stress in preeclampsia. Furthermore, it also examines potential interventions for reducing oxidative stress in preeclampsia, including natural antioxidant supplements, lifestyle modifications, mitochondrial targeting antioxidants, and pharmacological agents.A better understanding of the mechanism of action of proposed therapeutic strategies targeting oxidative stress is essential for the identification of companion biomarkers and personalized medicine approaches for the development of effective treatments of preeclampsia.</p>","PeriodicalId":13054,"journal":{"name":"Hypertension in Pregnancy","volume":"44 1","pages":"2445556"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies. rna结合蛋白在胃肠道恶性肿瘤肿瘤免疫微环境中的调控作用。
IF 3.6 3区 生物学
RNA Biology Pub Date : 2025-12-01 Epub Date: 2024-12-24 DOI: 10.1080/15476286.2024.2440683
Dongqi Li, Xiangyu Chu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang
{"title":"The regulatory roles of RNA-binding proteins in the tumour immune microenvironment of gastrointestinal malignancies.","authors":"Dongqi Li, Xiangyu Chu, Weikang Liu, Yongsu Ma, Xiaodong Tian, Yinmo Yang","doi":"10.1080/15476286.2024.2440683","DOIUrl":"10.1080/15476286.2024.2440683","url":null,"abstract":"<p><p>The crosstalk between the tumour immune microenvironment (TIME) and tumour cells promote immune evasion and resistance to immunotherapy in gastrointestinal (GI) tumours. Post-transcriptional regulation of genes is pivotal to GI tumours progression, and RNA-binding proteins (RBPs) serve as key regulators via their RNA-binding domains. RBPs may exhibit either anti-tumour or pro-tumour functions by influencing the TIME through the modulation of mRNAs and non-coding RNAs expression, as well as post-transcriptional modifications, primarily N6-methyladenosine (m<sup>6</sup>A). Aberrant regulation of RBPs, such as HuR and YBX1, typically enhances tumour immune escape and impacts prognosis of GI tumour patients. Further, while targeting RBPs offers a promising strategy for improving immunotherapy in GI cancers, the mechanisms by which RBPs regulate the TIME in these tumours remain poorly understood, and the therapeutic application is still in its early stages. This review summarizes current advances in exploring the roles of RBPs in regulating genes expression and their effect on the TIME of GI tumours, then providing theoretical insights for RBP-targeted cancer therapies.</p>","PeriodicalId":21351,"journal":{"name":"RNA Biology","volume":"22 1","pages":"1-14"},"PeriodicalIF":3.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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