IF 9.6 1区化学

Journal of Colloid and Interface Science Pub Date : 2027-01-15 Epub Date: 2026-09-03 DOI: 10.1016/j.jcis.2026.141522

Vo Thi Thanh Thuy, Nguyen Nhat Huy, Venkata Subbaiah Munagapati, Jet-Chau Wen, Yu-Chih Tsai, Wei-Hsin Chen, Yiu Fai Tsang, Kun-Yi Andrew Lin

{"title":"Development of ordered mesoporous ceria from metal-organic frameworks for efficient acetone oxidation: Morphologic and surficial advantages induced by surfactant-templated strategies.","authors":"Vo Thi Thanh Thuy, Nguyen Nhat Huy, Venkata Subbaiah Munagapati, Jet-Chau Wen, Yu-Chih Tsai, Wei-Hsin Chen, Yiu Fai Tsang, Kun-Yi Andrew Lin","doi":"10.1016/j.jcis.2026.141522","DOIUrl":"10.1016/j.jcis.2026.141522","url":null,"abstract":"Cerium oxide (CeO2) is one of the most effective catalysts for volatile organic compound (VOC) oxidation. However, the construction of ordered mesoporous CeO2 architectures through sustainable synthesis routes remains highly challenging. Metal-organic frameworks (MOFs) are promising sacrificial templates for the synthesis of oxides. Herein, we report a surfactant-regulated, alkali-metal-assisted aqueous strategy to construct ordered mesoporous CeO2 via UiO-66(Ce) templating. Pluronic was employed as a soft template, while inorganic bases (LiOH, NaOH, and KOH) were used to promote H2BDC deprotonation in water. The Li+, Na+, and K+ cations are believed to influence the self-assembly of UiO-66(Ce) framework (CeULi, CeUNa, and CeUK, respectively), leading to differences in the properties of the resulting particles. CeO2 derived from CeULi at low temperature, denoted as cCeULi, exhibited outstanding acetone conversion, reaching 90% at 207 °C. This is due to its mesoporous structure, the presence of Ce3+defects, and surface oxygen mobility. The cCeULi catalyst performed well over 10 cycles, averaging 87.9% efficiency over 25 h at 200 mg catalyst, 100 cc/min flow rate, and 600 ppm acetone. Also, cCeULi proved highly resistant to water vapor (5-10 vol%). In-situ DRIFTS analysis indicates that the acetone oxidation on cCeULi follows a Mars-van Krevelen mechanism involving lattice oxygen. Overall, the combination of morphological structure and surface chemical properties plays a key role in catalytic activity. This study is an important reference for the future development of ordered mesoporous CeO2 derived from MOFs.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"726 ","pages":"141522"},"PeriodicalIF":9.6,"publicationDate":"2027-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electron-deficient boron-containing additive induced Lewis acid interface with O-S/B-S chemical adsorption of polysulfides for durable sodium-sulfur batteries. 含缺电子硼添加剂诱导多硫化物O-S/B-S化学吸附的Lewis酸界面。

IF 9.6 1区化学

Journal of Colloid and Interface Science Pub Date : 2027-01-15 Epub Date: 2026-09-01 DOI: 10.1016/j.jcis.2026.141491

Jing Zhang, Fei Wang, Ying Han, Jiayi Feng, Jia Zeng, Fengping Xiao, Yuanyuan Gao, Peng Hu

{"title":"Electron-deficient boron-containing additive induced Lewis acid interface with O-S/B-S chemical adsorption of polysulfides for durable sodium-sulfur batteries.","authors":"Jing Zhang, Fei Wang, Ying Han, Jiayi Feng, Jia Zeng, Fengping Xiao, Yuanyuan Gao, Peng Hu","doi":"10.1016/j.jcis.2026.141491","DOIUrl":"10.1016/j.jcis.2026.141491","url":null,"abstract":"Room-temperature sodium‑sulfur (RT Na-S) batteries hold great promise for large-scale energy storage, yet they face severe challenges from polysulfide shuttling and sodium dendrite growth. To address these challenges, this study proposes an innovative strategy by introducing a boron-based additive, 2,4,6-trimethoxyboroxine (TMBX), into the propylene carbonate (PC)/NaClO₄ electrolyte to in-situ construct a boron-rich interphase. On the cathode side, the cathode electrolyte interface (CEI) layer is enriched with electron-deficient Lewis acidic B₂O₃, which chemisorbs soluble sodium polysulfides via BS and OS bonds. Simultaneously, this interphase forms a physical barrier due to its high mechanical strength and favorable structural properties, and the two effects work synergistically to suppress the shuttle effect. On the anode side, the inner solid electrolyte interface (SEI) layer that rich in boron-containing inorganic components can effectively inhibits sodium dendrite nucleation. Benefiting from the synergistic regulation of the boron-containing interphase, the TMBX-modified electrolyte endows Na-S cells with excellent performance. This work establishes a rational electrolyte design principle of leveraging boron-centered Lewis acidity for targeted polysulfide anchoring, coupled with a high-modulus interphase, offers a scalable and efficient strategy toward durable RT Na-S batteries.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"726 ","pages":"141491"},"PeriodicalIF":9.6,"publicationDate":"2027-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functionalization of separator with two-dimensional anionic nanosheets for interfacial regulation of lithium deposition in lithium metal batteries. 二维阴离子纳米片功能化隔膜对锂金属电池中锂沉积界面调控的研究。

IF 9.6 1区化学

Journal of Colloid and Interface Science Pub Date : 2027-01-15 Epub Date: 2026-09-01 DOI: 10.1016/j.jcis.2026.141500

Ying Zhang, Yuqin Wang, Xiaoyang Zheng, Guanyao Wang, Jinlong Jiang, Sikandar Iqbal, Xianzhong Yang, Haoxuan Liu, Chao Wu

{"title":"Functionalization of separator with two-dimensional anionic nanosheets for interfacial regulation of lithium deposition in lithium metal batteries.","authors":"Ying Zhang, Yuqin Wang, Xiaoyang Zheng, Guanyao Wang, Jinlong Jiang, Sikandar Iqbal, Xianzhong Yang, Haoxuan Liu, Chao Wu","doi":"10.1016/j.jcis.2026.141500","DOIUrl":"10.1016/j.jcis.2026.141500","url":null,"abstract":"Lithium metal anodes suffer from dendrite growth, low coulombic efficiency, and safety concerns, limiting their practical application in rechargeable batteries. Herein, polypropylene (PP) separators are functionalized with ultrathin 2D anionic (H3Sb3P2O14) HSPO nanosheets to construct a negatively charged interfacial layer. The HSPO layer improves electrolyte affinity, increases the Li+ transference number from 0.5 to 0.8, and guides a more homogeneous Li+ flux toward the lithium metal surface. Density functional theory calculations indicate stronger interactions between HSPO and Li/electrolyte species than those on pristine PP, while finite-element simulations and in situ optical microscopy reveal a more uniform electric-field distribution and regulated lithium deposition process. As a result, Li||Cu cells show improved plating/stripping stability over 250 cycles, and the Li||Li symmetric cell achieves a sevenfold increase in lifespan. Notably, the interfacial regulation strategy enables exceptional full-cell durability, delivering 2000 cycles for Li||LiFePO4 at 1C and 12,000 cycles for Li||I2 at 5C. This work highlights charged two-dimensional nanosheets as interfacial modifiers for separator-mediated regulation of ion transport and lithium deposition.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"726 ","pages":"141500"},"PeriodicalIF":9.6,"publicationDate":"2027-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of an organic-copper composite modified layer via displacement reaction on zinc anode. 锌阳极上置换反应制备有机铜复合改性层。

IF 9.6 1区化学

Journal of Colloid and Interface Science Pub Date : 2027-01-15 Epub Date: 2026-09-04 DOI: 10.1016/j.jcis.2026.141536

Teng Yu, Meiting Fu, Mengyu Liu, Zhen Hong, Wenxiang Sun, Haojie Liang, Lei Wang, Qi Sun, Caixia Li

{"title":"Preparation of an organic-copper composite modified layer via displacement reaction on zinc anode.","authors":"Teng Yu, Meiting Fu, Mengyu Liu, Zhen Hong, Wenxiang Sun, Haojie Liang, Lei Wang, Qi Sun, Caixia Li","doi":"10.1016/j.jcis.2026.141536","DOIUrl":"10.1016/j.jcis.2026.141536","url":null,"abstract":"Aqueous zinc-ion batteries face severe challenges in practical cycling, mainly including irregular zinc dendrite growth and unstable interfacial reactions, which greatly degrade the cycling performance. Herein, via a facile immersion method relying on a one-step in-situ spontaneous displacement reaction, an organic-inorganic composite layer composed of organic components and copper nanoparticles are fabricated on the surface of the zinc metal anode. The upper layer is enriched with carboxyl groups and Cu2+, constructing the upper layer by coordination interactions. Acting as migration sites and transport pathways for Zn2+, the as-formed SEI layer induces the uniform and ordered deposition of zinc. The bottom layer is composed of zincophilic copper clusters, which can form a compact physical shielding layer on the zinc anode surface and effectively inhibit interfacial corrosion. Benefiting from the synergistic effect, the symmetric cell achieves an ultra-long cycle life of over 4000 h at 3 mA cm-2, and still maintains a cycle life exceeding 2000 h even at a high current density of 10 mA cm-2. Meanwhile, the Cu-BTC@Zn//MVO full battery exhibits a 57% increase in capacity retention compared with bare Zn anode after 700 cycles. Meanwhile, this work reveals the synergistic regulation mechanism of the organic-inorganic composite layer toward Zn deposition, and provides a facile and practical strategy to construct stable artificial SEI layers for high performance zinc-metal anodes.","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"726 ","pages":"141536"},"PeriodicalIF":9.6,"publicationDate":"2027-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148943954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bcl11a preserves hematopoietic stem cell function in culture by restraining Ncf1-dependent ROS. Bcl11a通过抑制ncf1依赖性ROS来维持造血干细胞的功能。

IF 11.6 1区医学

Journal of Experimental Medicine Pub Date : 2027-01-04 Epub Date: 2026-11-03 DOI: 10.1084/jem.20261384

Xiang Xu, Linlin Zhang, Yandong An, Jing Wang, Xiaoyan Ding, Jing Xie, Yong Yu

{"title":"Bcl11a preserves hematopoietic stem cell function in culture by restraining Ncf1-dependent ROS.","authors":"Xiang Xu, Linlin Zhang, Yandong An, Jing Wang, Xiaoyan Ding, Jing Xie, Yong Yu","doi":"10.1084/jem.20261384","DOIUrl":"https://doi.org/10.1084/jem.20261384","url":null,"abstract":"Ex vivo expansion of hematopoietic stem cells (HSCs) is limited by culture-induced oxidative stress, yet the upstream transcriptional drivers remain poorly defined. Here, we show that the transcription factor Bcl11a is rapidly and persistently downregulated during HSC culture and that this decline drives functional deterioration. Bcl11a was both required and sufficient to maintain quiescence, clonogenic activity, and serially transplantable HSC function. Mechanistically, Bcl11a directly represses a Nox2 NADPH oxidase gene module, including Ncf1, encoding the p47phox organizer subunit; Ncf1 deletion reduced ROS and partially rescued the defects of Bcl11a-deficient HSCs. Rapamycin-but not the ROS scavenger N-acetylcysteine-restored Bcl11a expression, suppressed Ncf1 and ROS, and improved HSC function, identifying Bcl11a as a candidate effector linking mechanistic target of rapamycin complex 1 inhibition to redox control. This axis was conserved in human hematopoietic stem and progenitor cells, revealing a druggable transcriptional vulnerability of cultured HSCs and a framework for improving ex vivo-expanded grafts.","PeriodicalId":15760,"journal":{"name":"Journal of Experimental Medicine","volume":"224 1","pages":""},"PeriodicalIF":11.6,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149321770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disease associations for rare immune genetic variants require statistical or rule-based support. 罕见免疫遗传变异的疾病关联需要统计学或基于规则的支持。

Journal of human immunity Pub Date : 2027-01-04 Epub Date: 2026-10-19 DOI: 10.70962/jhi.20260099

Paul E Gray, Stuart G Tangye, Edwin P Kirk

{"title":"Disease associations for rare immune genetic variants require statistical or rule-based support.","authors":"Paul E Gray, Stuart G Tangye, Edwin P Kirk","doi":"10.70962/jhi.20260099","DOIUrl":"10.70962/jhi.20260099","url":null,"abstract":"Validating weak gene-disease associations requires statistical support from large case-control studies. In contrast, strong (e.g., monogenic) gene-disease associations may be established from relatively few affected individuals, when independent orthogonal evidence converges. Here, we examine four publications associating heterozygous variants in five genes-TNIP1, P2RY8, BLK, BANK1, and SH2B3-with autoimmune disease (predominantly systemic lupus erythematosus [SLE]). While we do not dispute the molecular findings of these studies, we do not accept the proposed disease associations, which lack case-control evidence and where high minor allele frequencies in non-disease populations, indicate that the genotypes are far too common to represent Mendelian disease alleles. Additionally, 8 of 18 alleles were searchable in UK Biobank, and none showed enrichment in SLE. Until further evidence emerges, caution is warranted in ascribing disease association to heterozygous genotypes in TNIP1, P2RY8, BLK, BANK1, and SH2B3, and linkage to patients in clinical pedigrees should not be taken as inferring a monoallelic inborn error of immunity.","PeriodicalId":521015,"journal":{"name":"Journal of human immunity","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pretransplant immune dysregulation and survival after HSCT in pediatric inborn errors of immunity. 儿童先天性免疫缺陷的移植前免疫失调和移植后的生存。

Journal of human immunity Pub Date : 2027-01-04 Epub Date: 2026-10-19 DOI: 10.70962/jhi.20260093

Andrés Soffia, Arturo Borzutzky, Cristián Sotomayor

{"title":"Pretransplant immune dysregulation and survival after HSCT in pediatric inborn errors of immunity.","authors":"Andrés Soffia, Arturo Borzutzky, Cristián Sotomayor","doi":"10.70962/jhi.20260093","DOIUrl":"10.70962/jhi.20260093","url":null,"abstract":"Allogeneic hematopoietic stem cell transplantation (HSCT) is curative for many inborn errors of immunity (IEIs), but the prognostic role of pretransplant immune dysregulation in pediatric patients remains unclear. We retrospectively studied 29 pediatric patients with genetically confirmed IEI undergoing HSCT between 2021 and 2025. Immune dysregulation was quantified using IDDA v2.1; HCT-CI and PARI were also calculated. 2-year overall survival (OS) was 79%, and event-free survival was 59%. Higher IDDA v2.1 scores were associated with inferior OS in univariate analysis (HR: 2.23 per five-point increase, P = 0.043) and remained associated in an exploratory multivariable model (HR: 2.76, P = 0.041). Harrell's C-statistic for OS was 0.722 for IDDA v2.1, 0.661 for HCT-CI, and 0.772 for PARI. Exploratory quadrant analyses suggested that IDDA v2.1 provides complementary information, identifying patients classified as lower risk by comorbidity indices who nonetheless had adverse outcomes. These findings support IDDA v2.1 as an adjunct pretransplant risk stratification tool in pediatric IEI.","PeriodicalId":521015,"journal":{"name":"Journal of human immunity","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149221326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slender lobes is a spindle matrix protein regulated by spindle envelope kinase Greatwall in oocytes. 细长叶是卵母细胞中受纺锤体包膜激酶壁调控的纺锤体基质蛋白。

IF 6.1 1区生物学

Journal of Cell Biology Pub Date : 2027-01-04 Epub Date: 2026-10-26 DOI: 10.1083/jcb.202606020

Rayane Kaade, Emma Peat, Charlotte Repton, Julia Niziol, Carmela Silva Mason, Li Ern Yap, Gera Pavlova, Hiroyuki Ohkura

{"title":"Slender lobes is a spindle matrix protein regulated by spindle envelope kinase Greatwall in oocytes.","authors":"Rayane Kaade, Emma Peat, Charlotte Repton, Julia Niziol, Carmela Silva Mason, Li Ern Yap, Gera Pavlova, Hiroyuki Ohkura","doi":"10.1083/jcb.202606020","DOIUrl":"10.1083/jcb.202606020","url":null,"abstract":"Chromosome segregation is mediated by microtubule-based machinery, the spindle. Microtubule-independent structures, often called the spindle matrix or the spindle envelope, have been reported to embed or surround the spindle, respectively. The concepts have been around for several decades, but they still remain enigmatic. Here, we show the spindle matrix and the spindle envelope form one functional unit crucial for spindle structure and function in oocytes. We found that in Drosophila oocytes, Slender lobes (Sle) protein is an integral component of the spindle matrix, which has a composition different from that in mitotic cells. We further found that Greatwall (Gwl) kinase localizes to the spindle envelope tightly surrounding the Sle spindle matrix in oocytes. Gwl promotes assembly of the Sle spindle matrix, which in turn determines the location of the Gwl spindle envelope. sle silencing in oocytes resulted in spindle abnormalities. Cosilencing experiments revealed that Sle buffers the impacts of compromised kinetochore-microtubule interaction on centromere bi-orientation in meiotic metaphase I.","PeriodicalId":15211,"journal":{"name":"Journal of Cell Biology","volume":"226 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13701656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149267873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deficiency of NBAS causes immune dysregulation due to hyperactivation of IFN signaling. NBAS缺乏导致IFN信号过度激活导致免疫失调。

Journal of human immunity Pub Date : 2027-01-04 Epub Date: 2026-10-28 DOI: 10.70962/jhi.20260018

Chenlu Liu, Liang Zhang, Meiping Lu, Yunyan Shen, Yuhao Yao, Fei Liu, Qintao Wang, Benshan Zhang, Li Guo, Xiaozhong Li, Qing Zhou, Jianhua Mao, Xiaomin Yu

{"title":"Deficiency of NBAS causes immune dysregulation due to hyperactivation of IFN signaling.","authors":"Chenlu Liu, Liang Zhang, Meiping Lu, Yunyan Shen, Yuhao Yao, Fei Liu, Qintao Wang, Benshan Zhang, Li Guo, Xiaozhong Li, Qing Zhou, Jianhua Mao, Xiaomin Yu","doi":"10.70962/jhi.20260018","DOIUrl":"10.70962/jhi.20260018","url":null,"abstract":"NBAS deficiency is a multisystem disorder, but its immunologic manifestations and underlying mechanisms remain poorly defined. Here, we expand the genotypic and phenotypic spectrum of NBAS deficiency through four patients carrying five loss-of-function NBAS mutations. Minigene assays and RNA analysis showed that these splicing or missense mutations resulted in aberrant alternative splicing. Clinically, the patients showed early-onset recurrent or persistent cytopenias and immune dysregulation, together with severe infections, inflammatory activation, and multi-organ involvement, including renal and neurologic manifestations. Transcriptomic analysis revealed overactivation of type I interferon signaling pathways compared with healthy controls, and single-cell RNA sequencing demonstrated that this upregulated inflammation was predominantly driven by myeloid cells. Together, these findings identify NBAS deficiency as a cause of immune dysregulation characterized by myeloid-driven type I interferonopathy, expand the clinical spectrum of NBAS-related disorders, and highlight the critical role of NBAS in maintaining immune homeostasis.","PeriodicalId":521015,"journal":{"name":"Journal of human immunity","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13715549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149291777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I IFN autoantibodies in three of seven Europeans with life-threatening Usutu virus infection. 在危及生命的Usutu病毒感染的7个欧洲人中，有3个存在I型IFN自身抗体。

Journal of human immunity Pub Date : 2027-01-04 Epub Date: 2026-11-03 DOI: 10.70962/jhi.20260092

Adrian Gervais, Paul Bastard, Lucy Bizien, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Alessandro Mancon, Davide Mileto, Irene Cassaniti, Francesca Conti, Jonas Schmidt-Chanasit, Dániel Cadar, David M Florian, Alessandro Borghesi, Anne Puel, Céline Delifer, Pierre Tiberghien, Xavier de Lamballerie, Guillaume André Durand, Judith H Aberle, Anna Nagy, Yannick Simonin, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova

{"title":"Type I IFN autoantibodies in three of seven Europeans with life-threatening Usutu virus infection.","authors":"Adrian Gervais, Paul Bastard, Lucy Bizien, Francesca Trespidi, Micol Angelini, Giada Rossini, Tiziana Lazzarotto, Fausto Baldanti, Francesca Rovida, Alessandro Ferrari, Alessandro Mancon, Davide Mileto, Irene Cassaniti, Francesca Conti, Jonas Schmidt-Chanasit, Dániel Cadar, David M Florian, Alessandro Borghesi, Anne Puel, Céline Delifer, Pierre Tiberghien, Xavier de Lamballerie, Guillaume André Durand, Judith H Aberle, Anna Nagy, Yannick Simonin, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova","doi":"10.70962/jhi.20260092","DOIUrl":"10.70962/jhi.20260092","url":null,"abstract":"We previously reported that two of three patients with severe Usutu virus (USUV) disease carried circulating autoantibodies (auto-Abs) neutralizing type I IFNs (AAN-I-IFN). Here, we studied four additional patients, bringing the total number of European patients with life-threatening USUV infection to seven (Austria, n = 1; France, n = 1; Hungary, n = 4; Italy, n = 1). Three of these patients (all male, aged 43, 77, and 78 years, one French and two Hungarian) had blood auto-Abs neutralizing at least 10 ng/ml IFN-α2 and IFN-ω and at least 1 ng/ml IFN-β. They suffered from meningitis (n = 1), meningoencephalitis (n = 1), or myocarditis (n = 1). The other four patients were similar demographically and clinically but had no detectable AAN-I-IFN. No AAN-I-IFN were found in the 63 individuals with silent USUV infection tested (P = 6.4 × 10-4, Fisher's exact test). These AAN-I-IFN increased the risk of life-threatening USUV disease by 98.8-fold (95% CI: 4.12-2,369; P = 0.0046, Firth's bias-corrected logistic regression) and, thus, account for almost half the cases of life-threatening USUV infection in Europe.","PeriodicalId":521015,"journal":{"name":"Journal of human immunity","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2027-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13729882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149330133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

全部最新文献