Schizophrenia: Genetics, neurological mechanisms, and therapeutic approaches.

IF 5.9 2区 医学 Q2 CELL BIOLOGY
Neural Regeneration Research Pub Date : 2026-03-01 Epub Date: 2025-05-06 DOI:10.4103/NRR.NRR-D-24-01375
Debbie Xiu En Lim, Shi Yun Yeo, Zhen You Ashley Chia, Aaron Zefrin Fernandis, Jimmy Lee, John Jia En Chua
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引用次数: 0

Abstract

Schizophrenia is a complex psychiatric disorder marked by positive and negative symptoms, leading to mood disturbances, cognitive impairments, and social withdrawal. While anti-psychotic medications remain the cornerstone of treatment, they often fail to fully address certain symptoms. Additionally, treatment-resistant schizophrenia, affecting 30%-40% of patients, remains a substantial clinical challenge. Positive, negative symptoms and cognitive impairments have been linked to disruptions in the glutamatergic, serotonin, GABAergic, and muscarinic pathways in the brain. Recent advances using genome-wide association study and other approaches have uncovered a significant number of new schizophrenia risk genes that uncovered new, and reinforced prior, concepts on the genetic and neurological underpinnings of schizophrenia, including abnormalities in synaptic function, immune processes, and lipid metabolism. Concurrently, new therapeutics targeting different modalities, which are expected to address some of the limitations of anti-psychotic drugs currently being offered to patients, are currently being evaluated. Collectively, these efforts provide new momentum for the next phase of schizophrenia research and treatment.

精神分裂症:遗传学、神经机制和治疗方法。
摘要:精神分裂症是一种以阳性和阴性症状为特征的复杂精神障碍,可导致情绪障碍、认知障碍和社交退缩。虽然抗精神病药物仍然是治疗的基石,但它们往往不能完全解决某些症状。此外,影响30%-40%患者的难治性精神分裂症仍然是一个重大的临床挑战。阳性、阴性症状和认知障碍与大脑中谷氨酸能、血清素、氨基丁酸能和毒蕈碱途径的破坏有关。利用全基因组关联研究和其他方法的最新进展发现了大量新的精神分裂症风险基因,这些基因揭示了精神分裂症的遗传和神经基础的新概念,并加强了先前的概念,包括突触功能异常、免疫过程和脂质代谢。与此同时,目前正在评估针对不同模式的新疗法,这些疗法有望解决目前提供给患者的抗精神病药物的一些局限性。总的来说,这些努力为精神分裂症研究和治疗的下一阶段提供了新的动力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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