Journal of Diabetes Investigation最新文献

{"title":"Classification of Japanese type 1 diabetes based on clinical phenotypes and its association with diabetic complications: Across-sectional study.","authors":"Takafumi Masuda, Naoto Katakami, Naohiro Taya, Kazuyuki Miyashita, Mitsuyoshi Takahara, Ken Kato, Iichiro Shimomura","doi":"10.1111/jdi.70108","DOIUrl":"https://doi.org/10.1111/jdi.70108","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the increasing number of studies using machine learning to develop individualized treatment strategies, only a few have been conducted in patients with type 1 diabetes. This study aimed to identify the characteristics of Japanese patients with type 1 diabetes, classified into subgroups using data-driven cluster analysis based on pancreatic beta-cell function, obesity, and glycemic control, and clarify the association between these subgroups and diabetic complications.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, a cluster analysis using three variables (C-peptide, body mass index, and glycated hemoglobin) in 206 Japanese patients with type 1 diabetes was performed. Multivariate logistic regression analysis was performed to compare the risk of diabetic complications by subgroup.</p><p><strong>Results: </strong>The cluster analysis identified four subgroups. Group 2 (n = 58), characterized by high body mass index levels, had a higher risk of hepatic steatosis than the control group (Group 1, n = 90). Meanwhile, Group 3 (n = 44), characterized by high glycated hemoglobin levels, had higher risks of retinopathy, polyneuropathy, elevated brachial-ankle pulse wave velocity, and hepatic steatosis than Group 1 and Group 4 (n = 14), characterized by residual endogenous insulin, had a higher risk of chronic kidney disease than Group 1.</p><p><strong>Conclusions: </strong>The risks of diabetic complications differed between subgroups of Japanese patients with type 1 diabetes. Tailored treatment approaches based on subgroup characteristics are a potential treatment option for reducing the risks of diabetic complications in this population.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of SGLT-2 inhibitors on COPD exacerbations in individuals with type 2 diabetes: A meta-analysis and Bayesian sensitivity analysis.","authors":"Muhammed Shabil, Jayaraj Patil, Prakasini Satapathy, Abhay M Gaidhane, Kattela Chennakesavulu, Nasir Vadia, Soumya V Menon, Rajashree Panigrahi, Ganesh Bushi, Mahendra Singh, Sanjit Sah, Awakash Turkar, Khang Wen Goh, S Govinda Rao, Edward Mawejje","doi":"10.1111/jdi.70111","DOIUrl":"https://doi.org/10.1111/jdi.70111","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease (COPD) and Type 2 diabetes mellitus (T2DM) frequently coexist, amplifying morbidity, mortality, and healthcare costs. COPD exacerbations are more frequent and severe in T2DM patients, necessitating therapies addressing both conditions. This systematic review and meta-analysis evaluates the impact of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) on COPD exacerbations in T2DM patients.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science until March 2025 for studies assessing SGLT-2i effects on COPD exacerbations in T2DM. Eligible studies included adults with T2DM-COPD overlap, reporting exacerbation outcomes. A random-effects meta-analysis and Bayesian hierarchical models were employed, with sensitivity and subgroup analyses.</p><p><strong>Results: </strong>Seven studies (449,530 participants) were included. SGLT-2i use reduced COPD exacerbation risk by 39% (pooled HR: 0.609, 95% CI: 0.431-0.858), with Bayesian analysis supporting a 31% reduction (HR: 0.64, 95% CrI: 0.40-0.88). Subgroup analyses showed superior efficacy vs DPP-4 inhibitors (HR: 0.618, 95% CI: 0.462-0.827) and sulfonylureas (HR: 0.620, 95% CI: 0.526-0.731), and modest benefit over GLP-1RAs (HR: 0.940, 95% CI: 0.890-0.992). Severe exacerbation reduction was non-significant (HR: 0.676, 95% CI: 0.340-1.344). Heterogeneity was high (I² ≥ 97.9%), but sensitivity analyses confirmed robustness.</p><p><strong>Conclusions: </strong>SGLT-2 inhibitors significantly reduce COPD exacerbations in T2DM patients, offering dual cardiometabolic and respiratory benefits. Their superiority over other antidiabetic agents supports prioritization in high-risk T2DM-COPD populations. Further trials are needed to validate effects on severe exacerbations and elucidate mechanisms.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pregnancy with metformin: Case reports for genetic insulin resistance syndrome and a literature review for gestational and type 2 diabetes.","authors":"Kai Yoshimura, Yushi Hirota, Tetsushi Hamaguchi, Takehito Takeuchi, Tomofumi Takayoshi, Shuichiro Saito, Mariko Ueda, Seiji Nishikage, Akane Yamamoto, Naoko Hashimoto, Wataru Ogawa","doi":"10.1111/jdi.70105","DOIUrl":"https://doi.org/10.1111/jdi.70105","url":null,"abstract":"<p><strong>Introduction: </strong>Genetic insulin resistance syndrome is characterized by severe insulin resistance due to functional abnormalities of the insulin receptor or downstream signaling molecules. Treatment typically includes insulin formulations and oral hypoglycemic agents such as metformin and sodium-glucose cotransporter 2 (SGLT2) inhibitors. However, achieving adequate glycemic control remains challenging. Moreover, given its rarity, reports on perinatal glycemic management in affected pregnancies remain scarce.</p><p><strong>Materials and methods: </strong>We describe prenatal care for two cases of genetic insulin resistance syndrome: a case of type A insulin resistance syndrome attributed to a heterozygous variant (Asn462Ser) of INSR (case 1) and a case of genetic insulin resistance syndrome due to a heterozygous variant (Arg649Trp) of PIK3R1 (case 2). We also review the literature for metformin treatment of gestational diabetes mellitus (GDM) or type 2 diabetes during pregnancy.</p><p><strong>Results: </strong>In case 1, perinatal glycemic management during three pregnancies was achieved with metformin alone, resulting in deliveries without any adverse events for both mother and infants. In case 2, administration of metformin during pregnancy initially reduced daily insulin requirements from 230 to 50 U/day, with a predelivery insulin dose of 112 U/day. At 34 weeks of gestation, a cesarean section was performed because of intractable uterine contractions. The child was diagnosed as small for gestational age and harbored the same genetic variant as the mother.</p><p><strong>Conclusions: </strong>The present cases suggest that metformin administration during pregnancy can be beneficial in cases of genetic insulin resistance syndrome, similar to its use in pregnancies associated with T2D or GDM.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid to high-density lipoprotein cholesterol ratio is associated with the prevalence of diabetic kidney disease in euthyroid patients with type 1 diabetes mellitus in China: A multicenter cross-sectional study.","authors":"Hui Zhao, Yu Wang, Yanli Liu, Zouxi Du, Limin Tian","doi":"10.1111/jdi.70107","DOIUrl":"https://doi.org/10.1111/jdi.70107","url":null,"abstract":"<p><strong>Introduction: </strong>Globally, the inadequate diagnosis and treatment of diabetic kidney disease remains a significant challenge, impeding effective management. The uric acid to high-density lipoprotein cholesterol ratio (UHR) has been associated with type 2 diabetes; however, its role in euthyroid patients with type 1 diabetic kidney disease (T1DKD) remains unclear. The aim of this study was to assess the association between UHR and T1DKD in patients with euthyroidism.</p><p><strong>Methods: </strong>This cross-sectional study included 335 euthyroid patients with type 1 diabetes mellitus (T1DM) from 1,485 eligible participants. Sociodemographic and blood test data were collected from inpatients of the endocrinology departments of 18 hospitals in Gansu Province.</p><p><strong>Results: </strong>Among the 335 euthyroid patients with T1DM (mean age 35.5 years, 57.6% males), 49.6% had T1DKD. In the fully adjusted model, T1DKD was positively associated with UHR (odds ratio [OR] = 2.29; 95% confidence interval [CI]: 1.36-3.87; P = 0.002). A positive relationship between T1DKD and UHR was also observed (nonlinear, P = 0.575). Subgroup analysis showed that this independent association remained consistent regardless of sex, body mass index, nationality, and marital status. The predictive value of UHR was ~22% higher in adults than in individuals aged <18 years.</p><p><strong>Conclusions: </strong>UHR is positively related to DKD in patients with euthyroid T1DM. Assessing the UHR might be a valuable part of follow-up visits for patients with T1DM.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles from adipose-derived mesenchymal stem cells prevent high glucose-induced retinal ganglion cell pyroptosis through a microRNA-26a-5p-dependent mechanism.","authors":"Lei Tang, Jian Zhang, Jianping Gao","doi":"10.1111/jdi.70100","DOIUrl":"https://doi.org/10.1111/jdi.70100","url":null,"abstract":"<p><strong>Objective: </strong>Mesenchymal stromal/stem cells have neuroprotective effects that limit damage to the retina, which is predominantly mediated by the released extracellular vesicles (EVs). This study aims to investigate the protective effect of adipose-derived mesenchymal stem cell-derived EVs (ADSC-EVs) against pyroptosis of retinal ganglion cells (RGCs).</p><p><strong>Methods: </strong>ADSC-EVs were isolated and then characterized. Mouse primary RGCs exposed to high glucose (HG) were applied for in vitro experiments. miR-26a-5p expression in RGCs after ADSC-EV treatment was determined by RT-qPCR. Target relation between miR-26a-5p and histone deacetylase 4 (HDAC4) was identified by luciferase reporter assay. miR-26a-5p blockad and HDAC4 ectopic expression experiments were conducted to clarify their functions in the pyroptosis of RGCs. The pyroptosis-associated protein GSDMD-N, inflammatory factors, and cell death were further evaluated by western blot, ELISA, and LDH assays, respectively.</p><p><strong>Results: </strong>Exposure to HG reduced RGC viability and increased cell death, GSDMD-N protein level, and IL-1β and IL-18 levels, indicating pyroptosis induction. However, these HG-caused alterations could be reversed by ADSC-EVs. ADSC-EVs transferred miR-26a-5p into RGCs where miR-26a-5p targeted HDAC4 to limit its expression and enhance histone H3 lysine 27 acetylation (H3K27ac) modification at the nuclear factor erythroid 2-related factor 2 (Nrf2) promoter region. This effect contributed to increases in Nrf2 protein level and nuclear translocation. Importantly, decreased H3K27ac modification at the Nrf2 promoter region could partially abrogate the inhibiting effect of ADSC-EVs on HG-induced RGC pyroptosis.</p><p><strong>Conclusion: </strong>Overall, our findings reveal the beneficial effects of ADSC-EVs shuttling miR-26a-5p on HG-induced RGCs and determine a potential mechanism responsible for pyroptosis.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative disease burden of early-onset and late-onset type 2 diabetes in the U.S.: Evidence from NHANES 2003-2018.","authors":"Shuoying Yue, Meng Su, Zihao Zhang, Zhiyi Hao, Man Li, Liang Zhang, Naijian Zhang, Zhilin Li, Qingcui Wu, Huijie Huang, Honglu Zhang, Yuanyuan Liu, Hui Wang, Jun Ma","doi":"10.1111/jdi.70096","DOIUrl":"https://doi.org/10.1111/jdi.70096","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the disease burden of type 2 diabetes (T2D) in early-onset (age < 40) and late-onset (age ≥ 40) in the U.S.</p><p><strong>Methods: </strong>Data obtained from the National Health and Nutrition Examination Survey 2003-2018. Prevalence, number, and disability-adjusted life years (DALYs) in early-onset and late-onset T2D were assessed.</p><p><strong>Results: </strong>There was a clear and steady upward trend in early-onset T2D, although the prevalence and number of late-onset T2D were higher than early-onset. The average loss of DALYs per capita (DALYs/per) in the early-onset T2D was higher than that in the late-onset. DALYs/per is higher in males than females in both early- and late-onset T2D groups. People living at or below the poverty line and those with education of high school and below had a higher DALYs/per of early-onset T2D. Among individuals with early-onset T2D, the DALYs/per loss was higher in the non-obesity group.</p><p><strong>Conclusion: </strong>There was a clear upward trend in the prevalence of early-onset T2D, and the loss of DALYs/per in early-onset T2D was higher than that in late-onset T2D. The attribution risk factors, like sex, education levels, income levels, and body mass index, for the burden of early-onset T2D varied, and measures need to be taken to target different populations.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory role of ATF2 in trophoblast ferroptosis via the PI3K/Akt/Nrf2 pathway in gestational diabetes mellitus.","authors":"Dandan Xia, Yuhui Zhang, Chenying Zhang, Huiyan Wang","doi":"10.1111/jdi.70115","DOIUrl":"https://doi.org/10.1111/jdi.70115","url":null,"abstract":"<p><strong>Aims/introduction: </strong>To investigate the expression of ATF2 in GDM patients and its impact on trophoblast viability and ferroptosis, as well as to explore the mechanism by which ATF2 regulates ferroptosis and affects trophoblast function in GDM.</p><p><strong>Materials and methods: </strong>Placental tissues from pregnant women with normal glucose levels and those with GDM were collected. The expression of ATF2 was detected using immunohistochemistry and western blot analysis, and its correlation with clinical maternal and neonatal outcomes was analyzed. The trophoblast cell line HTR8/SVneo was infected with ATF2-overexpressing or interfering lentivirus and stimulated with high glucose to assess changes in cell viability and ferroptosis. Transcriptome sequencing and functional experiments were conducted to identify potential downstream pathways of ATF2.</p><p><strong>Results: </strong>We found that ATF2 is highly expressed in GDM placental tissues and in trophoblast cells under high glucose conditions, and its overexpression is significantly positively correlated with increased levels of ferritin (P = 0.010), triglycerides (P = 0.039), and total cholesterol (P = 0.044) in GDM patients. Exogenous ATF2 expression further suppresses the proliferation of HTR8/SVneo cells under high glucose stimulation and promotes an increase in ferroptosis. Mechanistically, ATF2 targets the inhibition of the PI3K/Akt/Nrf2 pathway, reducing Nrf2 nuclear translocation and decreasing glutathione peroxidase 4 (GPX4) expression, thereby promoting ferroptosis in trophoblast cells and reducing their viability.</p><p><strong>Conclusions: </strong>ATF2 regulates ferroptosis and impacts trophoblast function in GDM through the PI3K/Akt/Nrf2 pathway, serving as a significant biomarker and a potential target for prevention and treatment of GDM.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin resistance and exercise-induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics.","authors":"Shun Masuda, Takashi Matsuzaka","doi":"10.1111/jdi.70113","DOIUrl":"https://doi.org/10.1111/jdi.70113","url":null,"abstract":"<p><p>Insulin resistance in muscle mainly disrupts non-canonical insulin signaling pathways. Exercise-induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study.","authors":"Kazuki Aoyama, Hidehiro Kaneko, Tatsuhiko Azegami, Akira Okada, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi","doi":"10.1111/jdi.70102","DOIUrl":"https://doi.org/10.1111/jdi.70102","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Diabetes causes microvascular complications and cardiovascular diseases, and identifying its risk factors is a critical issue. Muscle is a primary target organ of insulin; however, previous studies on the relationship between lean body mass and the risk of developing diabetes have reported inconsistent findings. This study aimed to evaluate the association between the predicted lean body mass index (LBMI), which can be easily calculated in daily clinical practice, and the risk of developing diabetes.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed a large scale real-world database to investigate the relationship between LBMI and diabetes risk in both men and women. The incidence of diabetes was determined using ICD-10 codes from an administrative claims database, and Cox regression and cubic spline models were employed.</p><p><strong>Results: </strong>The median age (interquartile range) was 59 (45-67) years for men and 63 (50-68) for women. Among 581,176 men and 721,605 women, a lower LBMI was associated with an increased risk of diabetes onset in both men and women (hazard ratio [95% confidence interval] (Men): Q1, 1.27 [1.23-1.32]; Q2, 1.07 [1.04-1.10]; Q3, 1.02 [0.99-1.04]; Q4. 1 [reference value], HR [95% CI] (Women): Q1, 1.10 [1.06-1.15]; Q2, 1.00 [0.97-1.03]; Q3, 0.99 [0.96-1.02]; Q4. 1 [reference value]). The restricted cubic spline regression model revealed that the risk of diabetes onset increased as LBMI decreased in both men and women.</p><p><strong>Conclusions: </strong>We demonstrated that a lower LBMI was associated with a higher risk of diabetes onset in both men and women.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of the intensity of physical performance and sedentary time with uric acid in patients with type 2 diabetes.","authors":"Jie Li, Ertao Zhang, Zhao Dong, Yan Liu","doi":"10.1111/jdi.70106","DOIUrl":"https://doi.org/10.1111/jdi.70106","url":null,"abstract":"<p><strong>Objective: </strong>High uric acid (UA) facilitates diabetes progression and is responsible for developing other diseases, such as cardiovascular disease and renal disease. Lifestyle modifications could lower UA level, but relevant evidence is required in patients with type 2 diabetes. This study intended to explore the influence of different physical activities and sitting time on UA level in patients with type 2 diabetes.</p><p><strong>Methods: </strong>Data on UA level, physical performance, and sitting time from 1892 patients with type 2 diabetes were retrospectively obtained from the Third People's Hospital of Datong, a subcenter of the Metabolic Management Center (MMC) Central database.</p><p><strong>Results: </strong>There were 15.8%, 29.7%, 29.5%, and 25.0% of patients with inactive, mild, moderate, and vigorous intensity of physical activity. UA level presented a U-shaped distribution among patients with different intensities of physical activity, with the lowest in patients with mild intensity of physical activity and the highest in patients with vigorous intensity of physical activity (P = 0.007). There were 58.1% and 41.9% of patients with a sitting time of ≤30 h/week and >30 h/week. UA level was lower in patients with sitting time ≤30 h/week than those with sitting time > 30 h/week (P = 0.014). The above findings were confirmed by multivariate linear regression models.</p><p><strong>Conclusions: </strong>Mild intensity of physical activity and sitting time ≤ 30 h/week are recommended for reducing UA level in patients with type 2 diabetes.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}