Journal of Diabetes Investigation最新文献_第2页

Letter to the Editor in Response to "Association between severity of diabetic complications and risk of cancer in middle-aged patients with type 2 diabetes".

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-19 DOI: 10.1111/jdi.70028

Syeda Aamna Wasti

引用次数: 0

Social determinants of health and type 2 diabetes in Asia.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-18 DOI: 10.1111/jdi.70024

Kyunghun Sung, Seung-Hwan Lee

{"title":"Social determinants of health and type 2 diabetes in Asia.","authors":"Kyunghun Sung, Seung-Hwan Lee","doi":"10.1111/jdi.70024","DOIUrl":"https://doi.org/10.1111/jdi.70024","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a major global public health challenge driven by a complex interplay of genetic, environmental, and social factors. This review highlights the effects of social determinants of health (SDOH) on T2DM in Asia, where rapid urbanization, worsening air pollution, and distinct socioeconomic structures uniquely influence disease outcomes. Key SDOH domains, socioeconomic status (education, income, and occupation), physical environment, food environment, healthcare access, and social context, were analyzed for their associations with T2DM prevalence, progression, and management. Among these, environmental and lifestyle shifts have emerged as particularly influential factors in Asia. Air pollution, particularly fine particulate matter, has been increasingly linked to insulin resistance and diabetes risk in Asian populations. Additionally, rapid urbanization and changing food environments contribute to rising T2DM incidence through shifts in lifestyle and dietary patterns. Across the diverse healthcare systems of Asian countries, primary care remains a universally critical component in addressing T2DM issues. Additionally, social capital and cohesion serve as protective factors, whereas social isolation heightens vulnerabilities. These insights underscore the importance of addressing SDOH in public health strategies to combat T2DM in Asia. Future research should prioritize longitudinal studies and culturally tailored interventions to reduce the region's diabetes burden.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real-world study.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-15 DOI: 10.1111/jdi.70023

Yiming Wu, Ying Gao, Xiaohui Guo, Junqing Zhang, Ang Li

{"title":"Effectiveness of finerenone in Chinese patients with type 2 diabetes mellitus and chronic kidney disease with microalbuminuria: A retrospective real-world study.","authors":"Yiming Wu, Ying Gao, Xiaohui Guo, Junqing Zhang, Ang Li","doi":"10.1111/jdi.70023","DOIUrl":"https://doi.org/10.1111/jdi.70023","url":null,"abstract":"Aim: No studies have specifically examined the effects of finerenone in treating type 2 diabetes patients with chronic kidney disease (CKD) and microalbuminuria. This study aimed to evaluate the effectiveness of finerenone in this group of patients.Methods: This retrospective real-world study (ChiCTR2400087169) included type 2 diabetes outpatients with CKD from the Peking University First Hospital between March 2023 and March 2024. All patients in this study had a urinary albumin-to-creatinine ratio (UACR) of 30-299 mg/g. The effects of finerenone were assessed by comparing UACR, HbA1c, creatinine, serum potassium, eGFR, and blood pressure at baseline and after treatment.Results: Sixty-four patients (39 males and 25 females), with a median age of 65.75 years and a median duration of T2DM of 15.21 years, were included. The baseline median UACR was 100.50 mg/g, significantly decreased to 61.27 mg/g (P < 0.001) at 3 months and 62.49 mg/g (P < 0.001) at 6 months after treatment. None of the other parameters differed significantly. Finerenone alone or in combination with ABS inhibitors, SGLT2 inhibitors, or GLP-1 agonists did not result in significant differences in UACR reduction. Patients with a >30% UACR decrease had significantly higher baseline systolic blood pressure (SBP) than those with a ≤30% decrease (P < 0.05). Furthermore, baseline SBP significantly decreased after 6 months of treatment in patients with a >30% UACR reduction (P < 0.05).Conclusions: Finerenone is effective in treating type 2 diabetes with CKD and microalbuminuria. Improved SBP control leads to a greater UACR reduction.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming barriers in continuous glucose monitoring: Challenges and future directions in diabetes management. 克服持续葡萄糖监测的障碍：糖尿病管理的挑战和未来方向。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-14 DOI: 10.1111/jdi.70019

Hung-Chun Chen, Yi-Hsuan Lai, Yi-Der Jiang

引用次数: 0

Glycemic control is worse in rural compared to urban type 2 diabetes in Bangladesh, irrespective of food security status. 在孟加拉国，无论食品安全状况如何，农村 2 型糖尿病患者的血糖控制都比城市患者差。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-13 DOI: 10.1111/jdi.70015

Md Kamruzzaman, Michael Horowitz, Muhammad Shafiqur Rahman, Harshal Deshmukh, Karen L Jones, Chinmay S Marathe

{"title":"Glycemic control is worse in rural compared to urban type 2 diabetes in Bangladesh, irrespective of food security status.","authors":"Md Kamruzzaman, Michael Horowitz, Muhammad Shafiqur Rahman, Harshal Deshmukh, Karen L Jones, Chinmay S Marathe","doi":"10.1111/jdi.70015","DOIUrl":"https://doi.org/10.1111/jdi.70015","url":null,"abstract":"Background: Food insecurity (FIS) affects around 25% of Bangladesh's population, and data from developed nations report higher FIS rates among individuals with type 2 diabetes (T2D), potentially worsening glycemic control. The importance of FIS to T2D has not been studied in developing countries such as Bangladesh, with substantial disparities in healthcare access, especially between rural and urban areas. We evaluated the relationships between food insecurity and glycemic control in the context of area of residence among individuals with T2D in Bangladesh.Methods: A total of 849 individuals with T2D attending diabetes clinics in four districts of Bangladesh completed a validated questionnaire to assess the FIS (a score ≥ 3 is indicative of FIS), which was compared with their sociodemographic and biochemical data. Two-way anova and multiple linear and binary logistic regression analyses were performed.Results: Both HbA1c levels (10.8% vs 9.5, P < 0.001) and the prevalence of FIS (45.8% vs 31.4%, P < 0.001) were higher in rural areas. According to two-way anova (0.87-1.78% mean difference, P < 0.05) and multiple linear regression model (β = 1.4, P < 0.001), HbA1c levels were also higher among rural than urban dwellers, irrespective of their FIS status. Rural dwellers were also more than twice as likely to have suboptimal glycemic control (HbA1c ≥7%; AOR: 2.26 (1.35-3.97), P < 0.05), irrespective of their food security status (AOR: 1.19 (0.78-1.84, P > 0.05)).Conclusions: In Bangladesh, rural residence is associated with poor glycemic control, irrespective of food security status, and thus is an important social determinant of diabetes care that warrants further exploration.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-12 DOI: 10.1111/jdi.70006

Jianxing Chen, Wenlinng Zeng, Dandan Dai, Yujin Tang, Yangwen Dong, Zilan Zhong, Miao Zhou, Jianhong Ye

{"title":"A systematic analysis and prediction of the disease burden of ischemic heart disease caused by hyperglycemia.","authors":"Jianxing Chen, Wenlinng Zeng, Dandan Dai, Yujin Tang, Yangwen Dong, Zilan Zhong, Miao Zhou, Jianhong Ye","doi":"10.1111/jdi.70006","DOIUrl":"https://doi.org/10.1111/jdi.70006","url":null,"abstract":"Objective: This study aims to analyze the disease burden of ischemic heart disease (IHD) caused by hyperglycemia and its changing trend, and to construct a visualization platform for disease burden and forecast trends on the Shiny platform.Materials and methods: Using data from the 2021 Global Burden of Disease Study, we analyzed deaths and disability-adjusted life years (DALYs) due to IHD triggered by hyperglycemia, with detailed analysis by region, gender, and age. The age-period-cohort model was used to assess the impact of age, cohort, and period on age-standardized disease rates across different Socio-Demographic Index (SDI) regions, and decomposition analysis was employed to disentangle the contributions of population, aging, and epidemiological changes.Results: In 2021, approximately 14-15% of IHD's DALYs and deaths were attributed to high fasting plasma glucose (HFPG), with a nonsignificant decrease in the annual average percentage change of DALYs. In middle, low-middle, and low SDI regions, the age-standardized mortality rates caused by HFPG are increasing, particularly among males. In high-middle and high SDI regions, the effects of aging and epidemiological changes surpass population growth, whereas in low SDI regions, population growth is the main factor. By 2050, the global Age-Standardized Mortality Rate of IHD attributed to HFPG is projected to reach 16.96. More data can be accessed by visiting the disease burden visualization platform.Conclusion: Global HFPG-induced IHD health presents significant imbalances. In low SDI regions with larger populations and more unbalanced healthcare distribution, there is a need to strengthen the construction of medical levels.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of treatment intensified (add-on to metformin) adults with type 2 diabetes in Thailand: A cross-sectional real-world study (CONVERGE).

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-12 DOI: 10.1111/jdi.14409

Chutintorn Sriphrapradang, Ammarin Thakkinstian, Ratiporn Chinthammit, Gurudutt Nayak

{"title":"Characterization of treatment intensified (add-on to metformin) adults with type 2 diabetes in Thailand: A cross-sectional real-world study (CONVERGE).","authors":"Chutintorn Sriphrapradang, Ammarin Thakkinstian, Ratiporn Chinthammit, Gurudutt Nayak","doi":"10.1111/jdi.14409","DOIUrl":"https://doi.org/10.1111/jdi.14409","url":null,"abstract":"Objective: The CONVERGE (Cardiovascular Outcomes and Value in the Real-World with GLP-1RAs) study characterized demographics, clinical characteristics, and medication use in treatment-intensified (add-on to metformin) adults with type 2 diabetes (T2D) in Thailand.Methods: A retrospective cross-sectional study of data from medical records (Jul 26, 2013, to Dec 31, 2017) was descriptively summarized for overall population and subgroups defined by glucose-lowering agent (GLA) classes.Results: Data from 1,000 adults were collected in reverse chronological order. At baseline, the mean (SD) age was 60 (12) years, HbA1c was 8.0%, and the median (IQR) T2D duration was 1.0 (0.2-2.4) years. Patients taking SGLT2-is (sodium glucose cotransporter-2 inhibitors) had a longer T2D duration (1.8 years, 0.8-3.2), GLP-1RAs (glucagon-like peptide-1 receptor agonists) had a higher body mass index of 32.0 (8.84) kg/m2, and insulin subgroup had a higher HbA1c 8.5% (7.5-10.1). The utilization of GLP-1 RAs/SGLT-2is was low (1.5% and 6%, respectively). Among the subgroups, most patients in the GLP-1RA (80.0%) and insulin subgroup (81.3%) receiving 3/≥4 GLAs. The most frequently prescribed GLAs post-metformin were sulfonylureas (45.2%) and dipeptidyl peptidase-4 inhibitors (39.4%). Overall, 90% received ≥1 cardiovascular (CV) medication; lipid-lowering agents (78%) were the most prescribed.Conclusions: These results indicate low utilization of GLAs with CV benefits, attributed to a lack of CV benefit data during the study period and partial reimbursement implementation. Future studies must identify barriers to adoption and estimate the usage of these GLAs with CV benefits as more evidence becomes available on positive CV outcomes to improve patient care in Thailand.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two cases of neonatal hyperglycemia caused by a homozygous COQ9 stop-gain variant.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-10 DOI: 10.1111/jdi.70022

Russell Donis, Maryam Al Badi, Nadia Alhashmi, Andrew T Hattersley, Sarah E Flanagan, Elisa De Franco

引用次数: 0

Revisiting the causal impact of lipid traits on metabolic dysfunction-associated fatty liver disease: Insights from a multidimensional plasma lipid profile.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-07 DOI: 10.1111/jdi.14413

Fang Xie, Wenkai Zheng, Jing Chen, Chuanxia Yao, Cong Li, Li Tang, Ping Li, Shanzhong Tan

{"title":"Revisiting the causal impact of lipid traits on metabolic dysfunction-associated fatty liver disease: Insights from a multidimensional plasma lipid profile.","authors":"Fang Xie, Wenkai Zheng, Jing Chen, Chuanxia Yao, Cong Li, Li Tang, Ping Li, Shanzhong Tan","doi":"10.1111/jdi.14413","DOIUrl":"https://doi.org/10.1111/jdi.14413","url":null,"abstract":"Aims: Recent advancements in plasma lipidomes genome-wide association studies data have enhanced our understanding of lipid categories, significantly improving risk assessments for metabolic dysfunction-associated fatty liver disease (MAFLD) beyond traditional lipid biomarkers.Materials and methods: This study utilized Mendelian randomization (MR) to assess the causal relationships between 179 lipid species across 13 subclasses and MAFLD, primarily using the Wald ratio and IVW methods. Corrections were made using false discovery rate (FDR), supplemented by Bayesian colocalization analysis.Results: Elevated levels of genetically predicted phosphatidylcholine (16:0_16:1) [ORWald ratio = 2.638, 95% CI 1.557-4.469, P = 3.11 × 10-4], phosphatidylcholine (16:1_18:0) (ORWald ratio = 2.644, 95% CI 1.559-4.486, P = 3.11 × 10-4), triacylglycerol (46:2) (ORWald ratio = 2.515, 95% CI 1.524-4.153, P = 3.11 × 10-4), and triacylglycerol (48:2) (ORIVW = 1.863, 95% CI 1.300-2.669, P = 6.95 × 10-4) were significantly associated with increased MAFLD risk, with rs1260326 within the GCKR gene playing a crucial role. Colocalization analysis indicated that in significant evidences, the posterior probability for hypothesis 4 was over 80%, identifying rs780093 as a shared causal variant. Additionally, 16 suggestive evidences were identified.Conclusion: The study confirmed the significant role of specific lipid molecules in influencing MAFLD risk, providing new scientific bases and potential therapeutic targets for future treatment strategies.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features among adult-onset type 1 diabetes, distribution of subtypes, and differences in probable and definite slowly progressive insulin-dependent diabetes mellitus: A single hospital-based study over a 13-year period. 成人初发 1 型糖尿病的临床特征、亚型分布以及可能和明确的缓慢进展型胰岛素依赖型糖尿病的差异：一项为期 13 年的单一医院研究。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-07 DOI: 10.1111/jdi.70012

Hiroko Takaike, Junnosuke Miura, Satoshi Takagi, Shota Mochizuki, Tetsuya Babazono

{"title":"Clinical features among adult-onset type 1 diabetes, distribution of subtypes, and differences in probable and definite slowly progressive insulin-dependent diabetes mellitus: A single hospital-based study over a 13-year period.","authors":"Hiroko Takaike, Junnosuke Miura, Satoshi Takagi, Shota Mochizuki, Tetsuya Babazono","doi":"10.1111/jdi.70012","DOIUrl":"https://doi.org/10.1111/jdi.70012","url":null,"abstract":"Aims: In Japan, type 1 diabetes (T1D) is classified into three subtypes based on its onset patterns; however, the proportion of each subtype remains unexplored. To elucidate the heterogeneity in adult-onset type 1 diabetes, we compared the frequencies of subtypes and clinical features by age at onset.Materials and methods: This cross-sectional, observational, single-institution study included 482 individuals (161 male) with T1D. The clinical and laboratory data, including glutamic acid decarboxylase autoantibodies, were extracted from the medical records.Results: The number of adults who developed T1D decreased with age. Among all patients, 62% (n = 299) had acute-onset T1D, 27% (n = 131) had slowly progressive T1D (SPIDDM), and 11% (n = 52) had fulminant T1D. The proportion of patients with fulminant T1D was approximately equivalent in all age groups; however, the percentage of patients with acute-onset T1D decreased from 78% in the 20-29 age group to 27% in the 70-79 age group. The proportion of patients with SPIDDM significantly increased with age, ranging from 16% in the 20-29 age group to 60% in the 70-79 age group. Among patients with SPIDDM, the prevalence of definite SPIDDM was 89%, and this prevalence did not differ based on the age at onset. Body mass index and C-peptide levels among patients with probable SPIDDM were significantly higher than those among patients with definite SPIDDM.Conclusions: The proportion of adult-onset T1D subtypes differed according to the age at onset. In adult-onset T1D, some etiological differences may be based on age at onset.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0