Journal of Diabetes Investigation最新文献_第2页

Fingertip skin autofluorescence as a non-invasive marker for vascular complications in patients with type 2 diabetes. 指尖皮肤自身荧光作为2型糖尿病患者血管并发症的非侵入性标志物

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-29 DOI: 10.1111/jdi.70169

Minoru Takeshita, Takeshi Matsumura, Aiko Arimura, Hiroyuki Takahashi, Yoshimi Muta, Shigeru Kawade, Dai Yamagami, Takahisa Deguchi, Tatsuya Kondo, Mikihiko Yamanaka, Ryoji Nagai, Daiji Kawanami, Toshihiko Yanase, Takashi Nomiyama, Yoshihiko Nishio, Eiichi Araki, Naoto Kubota

{"title":"Fingertip skin autofluorescence as a non-invasive marker for vascular complications in patients with type 2 diabetes.","authors":"Minoru Takeshita, Takeshi Matsumura, Aiko Arimura, Hiroyuki Takahashi, Yoshimi Muta, Shigeru Kawade, Dai Yamagami, Takahisa Deguchi, Tatsuya Kondo, Mikihiko Yamanaka, Ryoji Nagai, Daiji Kawanami, Toshihiko Yanase, Takashi Nomiyama, Yoshihiko Nishio, Eiichi Araki, Naoto Kubota","doi":"10.1111/jdi.70169","DOIUrl":"https://doi.org/10.1111/jdi.70169","url":null,"abstract":"Aims/introduction: This study aimed to investigate whether non-invasive fingertip autofluorescence can evaluate micro- and macrovascular complications in patients with type 2 diabetes.Materials and methods: This multicenter cross-sectional study recruited 452 patients with type 2 diabetes between August 2017 and January 2023. Fingertip autofluorescence levels were measured using AGEs Sensor (Air Water Biodesign, Kobe, Japan).Results: Fingertip autofluorescence correlated with body mass index, glycated hemoglobin, estimated glomerular filtration rate, and duration of diabetes. Fingertip autofluorescence was increased in parallel with the number of micro- and macrovascular complications. A significant relationship was noted between fingertip autofluorescence as a dependent variable and sex, serum albumin, history of diabetic nephropathy, and coronary arterial disease as independent variables. Logistic regression analysis indicated the association of fingertip autofluorescence as a dichotomous variable with diabetic nephropathy as a significant predictor variable adjusted for age, sex, duration of diabetes, smoking status, and serum albumin. The receiver operating characteristic curve revealed that fingertip autofluorescence could be used to identify the presence of macrovascular complications (area under the curve: 0.65, 95% confidence interval: 0.585-0.707, P < 0.001).Conclusions: Fingertip autofluorescence may be a convenient and non-invasive potential marker for evaluating micro- and macrovascular complications in patients with type 2 diabetes.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social stigma of diabetes in Taiwan: An analysis of public perceptions and disease name unpleasantness. 台湾糖尿病的社会污名化：大众认知与疾病名称不愉快之分析。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-27 DOI: 10.1111/jdi.70160

Der-Yan Han, Po-Fang Tsai, Po-Ju Hung, I-Weng Yen, Shih-Tzer Tsai, Mei Chang, Hung-Yuan Li

{"title":"Social stigma of diabetes in Taiwan: An analysis of public perceptions and disease name unpleasantness.","authors":"Der-Yan Han, Po-Fang Tsai, Po-Ju Hung, I-Weng Yen, Shih-Tzer Tsai, Mei Chang, Hung-Yuan Li","doi":"10.1111/jdi.70160","DOIUrl":"https://doi.org/10.1111/jdi.70160","url":null,"abstract":"Aims: Social stigma related to diabetes affects self-care and psychological well-being. In Taiwan, negative perceptions of \"diabetes mellitus\" may contribute to this stigma. This study explores public attitudes toward people with diabetes and the unpleasantness linked to the disease name.Methods: A household telephone survey in Taiwan was conducted using stratified random sampling. Social distance was measured with the Diabetes Social Distance Scale, and the unpleasantness of disease names was recorded on an 11-point scale.Results: Among the 982 subjects recruited (mean age 54.3 years), the Taiwanese public showed a high willingness to interact with individuals with diabetes, except in marriage contexts (43.3% expressed reluctance). Compared with a report from Singapore, social distance was higher in Taiwan (mean score 12.4 vs 10.8, P < 0.001). Younger age, female gender, higher education, and northern residence correlated with lower social distance scores. Additionally, 15.2% rated \"diabetes mellitus\" as unpleasant, which was higher than \"metabolic syndrome\" (10.7%) and \"hypertension\" (7.3%), but lower than the former name of schizophrenia (42.1%).Conclusions: While stigma toward diabetes in Taiwan is generally low, specific demographic groups may benefit from targeted education. Renaming \"diabetes mellitus\" may have a limited impact on reducing stigma, emphasizing the need for broader awareness efforts.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between time in range and mild cognitive impairment in older adults with type 2 diabetes mellitus. 老年2型糖尿病患者范围时间与轻度认知障碍的相关性

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-27 DOI: 10.1111/jdi.70161

Jiajun Bao, Tianhong Xu, Ting Gu, Yi Sun, Yilan Jiang, Jing Xiao, Yunjuan Gu

{"title":"Correlation between time in range and mild cognitive impairment in older adults with type 2 diabetes mellitus.","authors":"Jiajun Bao, Tianhong Xu, Ting Gu, Yi Sun, Yilan Jiang, Jing Xiao, Yunjuan Gu","doi":"10.1111/jdi.70161","DOIUrl":"https://doi.org/10.1111/jdi.70161","url":null,"abstract":"Aims: To investigate the association between time in range (TIR) and mild cognitive impairment (MCI) in older adult patients with type 2 diabetes mellitus (T2DM) and the contributions of various indicators to MCI.Materials and methods: Two hundred and three participants received continuous glucose monitoring and cognitive assessments. Relative weight analysis assessed TIR and other factors' contributions to MCI. Binary logistic analysis explored TIR-MCI associations across the sample and by age and sex.Results: TIR showed a stronger association with MCI than diabetes duration, education, systolic blood pressure (SBP), urinary albumin-creatinine ratio (UACR), and C-peptide (25.59% relative weight). Multivariable-adjusted odds ratios (ORs) for MCI declined with increasing TIR quartile (Q) (Q1 [reference group], ≤40%; Q2, 40.3-51.1%, OR 0.402, 95% confidence interval [CI] 0.094-1.717; Q3, 51.2-61.2%, OR 0.113, 95% CI 0.023-0.565; Q4, ≥61.3%, OR 0.050, 95% CI 0.007-0.343). This protective association remained when TIR was treated as a continuous variable and adjusted for covariates (OR 0.917, 95% CI 0.867-0.969, P = 0.002). Women with TIR ≥61.3% had lower MCI risk. Men with TIR 51.2-61.2% had lower MCI risk.Conclusions: Besides hemoglobin A1c, clinicians should consider low TIR as a risk factor for MCI in older T2DM patients. Women potentially require a higher TIR target to prevent MCI.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Betagenin: New intestine-derived hormone which ameliorates diabetes. 倍他agenin：一种新的肠源性激素，可改善糖尿病。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-24 DOI: 10.1111/jdi.70167

Yong Kyung Kim, KyuChang Won

引用次数: 0

Response to commentary on 'A prediction model for diabetes complications using the Kokuho Database and its application to public health services in Japan'. 对“使用Kokuho数据库的糖尿病并发症预测模型及其在日本公共卫生服务中的应用”评论的回应。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-23 DOI: 10.1111/jdi.70162

Shumpei Chiba, Takaaki Itoga, Kazuo Asada, Daisuke Yabe

引用次数: 0

Commentary on: Inhibition of LINC00707/miR-223-3p/FKBP5 axis has a protective effect on diabetic kidney disease. 点评：抑制LINC00707/miR-223-3p/FKBP5轴对糖尿病肾病具有保护作用。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-22 DOI: 10.1111/jdi.70158

Yirui Zhao, Fengyue Zhang

引用次数: 0

Cordycepin nephroprotection: From STZ mouse to human T2D. 虫草素肾保护作用：从STZ小鼠到人T2D。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-20 DOI: 10.1111/jdi.70159

Jing Yang

引用次数: 0

Molecular mechanism for platelet hyperreactivity in diabetes mellitus. 糖尿病血小板高反应性的分子机制。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-17 DOI: 10.1111/jdi.70154

Hideaki Kaneto

引用次数: 0

Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism. 外周血线粒体基因组变异与妊娠期糖尿病和产后糖代谢异常的关系。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-12 DOI: 10.1111/jdi.70152

Qing Luo, Jiankun Zhou, Haiyun Wu, Xiayan Qiu, Chunyan Xian, Xiaoting Zhan, Jinbo Liu

{"title":"Associations between peripheral blood mitochondrial genomic variants and gestational diabetes mellitus and postpartum abnormal glucose metabolism.","authors":"Qing Luo, Jiankun Zhou, Haiyun Wu, Xiayan Qiu, Chunyan Xian, Xiaoting Zhan, Jinbo Liu","doi":"10.1111/jdi.70152","DOIUrl":"https://doi.org/10.1111/jdi.70152","url":null,"abstract":"Aims/introduction: The aim of the study was to investigate the association of single nucleotide polymorphisms, haplogroups, and copy number in the D-loop region of mitochondrial DNA (mtDNA) with the genetic susceptibility to gestational diabetes mellitus (GDM) and postpartum abnormal glucose metabolism (AGM).Materials and methods: This was a case-control study in which peripheral blood samples were collected from 500 GDM patients and 500 normal pregnant women from 14 to 20 weeks of pregnancy. The sequence of the D-loop region of mtDNA was detected by Sanger sequencing, and the copy number of mtDNA was detected by qPCR.Results: Analysis of SNPs in the D-loop region of mtDNA showed that 249d was a risk factor and 309+C and 16193+C were protective factors for GDM. The mtDNA haplogroups R9 and M* were a risk factor and protective factor for GDM, respectively. Compared to the group with normal postpartum glucose tolerance, the haplogroups M7b and N9a were associated with an increased risk of AGM. The whole blood mtDNA copy number was lower in the GDM group than in the control group and was also lower in the postpartum AGM group than in the postpartum normal group. The plasma free mtDNA copy number was higher in the GDM group than in the control group, and higher in the postpartum AGM group than in the normal postpartum group.Conclusions: Mitochondrial genomic variants are associated with the risk of GDM and postpartum AGM, and may provide some etiologic evidence for GDM and postpartum AGM.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145038807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical methodological concerns regarding the association between metabolic indices and microvascular complications in type 2 diabetes. 代谢指标与2型糖尿病微血管并发症之间关系的关键方法学关注。

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-08 DOI: 10.1111/jdi.70153

Wenya Han, Mina He

引用次数: 0