Journal of Diabetes Investigation最新文献

{"title":"Correction to \"Epidemiological characteristics and risk factors for heart failure in Japanese patients with type 2 diabetes: A retrospective analysis of the J-DREAMS database\".","authors":"","doi":"10.1111/jdi.70422","DOIUrl":"10.1111/jdi.70422","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1861"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in the assessment of time in range during caloric restriction in type 2 diabetes with obesity.","authors":"Ying Li","doi":"10.1111/jdi.70389","DOIUrl":"10.1111/jdi.70389","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1858-1859"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Methodological concerns on the predictive performance evaluation of anthropometric indices.","authors":"Kiavash Semnani, Mostafa Qorbani","doi":"10.1111/jdi.70375","DOIUrl":"10.1111/jdi.70375","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1857"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study.","authors":"Xi May Zhen, Glynis Ross, Amanda Gauld, Arianne Sweeting, Alberto Nettel-Aguirre, Stephanie Noonan, Maria Constantino, Anna-Jane Harding, Adam Mackie, Hend Chatila, Margaret McGill, Timothy Middleton, Ted Wu, Stephen M Twigg, Jencia Wong","doi":"10.1111/jdi.70440","DOIUrl":"https://doi.org/10.1111/jdi.70440","url":null,"abstract":"<p><strong>Objective: </strong>To explore the associations of maternal overweight/obesity and pre-pregnancy body mass index (BMI) on glycemia and pregnancy outcomes in women with pregestational type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM).</p><p><strong>Research design and methods: </strong>We examined prospectively collected data (2010-2019) involving 264 singleton pregnancies affected by pregestational T1DM or T2DM. On separate analyses within each diabetes subtype, pregnancy outcomes were compared across maternal BMI categories and using BMI as a continuous variable. Co-primary outcomes included preterm delivery, large-for-gestational age (LGA) infants, and pre-eclampsia.</p><p><strong>Results: </strong>In those with T1DM (N = 124, 46% overweight or obese), we did not find an association between increasing BMI category and greater risks of pre-eclampsia, preterm delivery, or LGA infants. However, amongst the women with T1DM, overweight and obesity were associated with higher odds of exceeding the first trimester HbA1c target (6.5%), and each 1 kg/m² increase in BMI was associated with higher odds of excess GWG as well as caesarean delivery. In the T2DM cohort (N = 140, 90% overweight or obese), each 1 kg/m² increase in BMI above ethnicity-adjusted normal range was associated with increased odds of pre-eclampsia (aOR 1.082, 95% CI 1.024 to 1.144) and preterm delivery (aOR 1.042, 95% CI 1.001 to 1.084). In the T2DM cohort, the odds of LGA were numerically higher with each 1 kg/m² increase in BMI, but this was no longer statistically significant after adjustment for potential confounders.</p><p><strong>Conclusions: </strong>On separate analyses within each diabetes subtype, maternal overweight/obesity was potentially associated with increased odds of pre-eclampsia and preterm delivery in the T2DM cohort. Amongst those with T1DM, maternal overweight/obesity was associated with non-attainment of first trimester HbA1c targets. Regression analyses were performed in an exploratory and hypothesis-generating manner, and larger-scale studies are required to directly compare the effects of maternal overweight/obesity on pregnancy outcomes in T1DM vs T2DM.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149101798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological concerns regarding the prediction model for ADL decline in older adults with diabetes.","authors":"Xueting Wang, Ying Zhao","doi":"10.1111/jdi.70405","DOIUrl":"10.1111/jdi.70405","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1860"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythritol and metabolic dysfunction-associated steatotic liver disease: A sweet friend, bitter foe, or reliable fellow traveler?","authors":"Kelly Hiu-Ching Wong, David Tak-Wai Lui, Chi-Ho Lee","doi":"10.1111/jdi.70453","DOIUrl":"10.1111/jdi.70453","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating miR-342-3p as a biomarker for diagnosing gestational diabetes mellitus and predicting adverse perinatal outcomes: A retrospective cohort study.","authors":"Kangjun Yu, Sanqiang Niu, Hai Liang","doi":"10.1111/jdi.70437","DOIUrl":"10.1111/jdi.70437","url":null,"abstract":"<p><strong>Aims: </strong>This study evaluated the clinical utility of circulating miR-342-3p for diagnosing gestational diabetes mellitus (GDM) and predicting adverse perinatal outcomes (APOs).</p><p><strong>Methods: </strong>A retrospective cohort of 261 GDM women (the GDM group) and 261 propensity score-matched healthy controls (the Normal group) was analyzed. Circulating miR-342-3p levels were quantified by RT-qPCR, and diagnostic and predictive performances were assessed using receiver operating characteristic curves. Correlations with fasting plasma glucose (FPG), 2-h postprandial glucose (2hPG), and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were evaluated by Spearman's analysis. Logistic regression was used to analyze the independent association between circulating miR-342-3p expression and APOs.</p><p><strong>Results: </strong>Circulating miR-342-3p was significantly elevated in GDM patients versus controls and demonstrated early diagnostic potential for GDM (AUC = 0.835). In GDM patients, miR-342-3p levels showed moderate positive correlations with FPG, 2hPG, and HOMA-IR (r = 0.780, 0.578, 0.613). miR-342-3p levels were elevated in both the GDM-APOs and the Normal-APOs groups compared with their respective non-APO subgroups. Circulating miR-342-3p yielded AUCs of 0.697 and 0.599 for predicting APOs in the GDM and Normal groups, respectively. After adjusting for pre-pregnancy BMI, parity, FPG, and 2hPG, the ORs for APOs per unit increase in miR-342-3p were 1.338 in the GDM group and 2.284 in the Normal group.</p><p><strong>Conclusion: </strong>Circulating miR-342-3p may serve as a valuable adjunctive biomarker for early GDM screening. Across both GDM and non-GDM populations, circulating miR-342-3p is significantly associated with APOs, suggesting cross-population applicability, though GDM status may modulate the strength of this association.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic health, independent of body mass index, is associated with mortality risk in type 1 diabetes.","authors":"Jung A Kim, Jimi Choi, Kyeong Jin Kim, Soo Myoung Shin, Young-Eun Kim, Kyoung Jin Kim, Hee Young Kim, Nam Hoon Kim, Sin Gon Kim","doi":"10.1111/jdi.70457","DOIUrl":"10.1111/jdi.70457","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Although a low body mass index (BMI) is traditionally associated with high mortality in type 1 diabetes (T1D), the increasing prevalence of obesity and its association with mortality warrant further research.</p><p><strong>Materials and methods: </strong>Using a nationwide Korean database from 2002 to 2018, we classified patients with T1D into six categories based on metabolic health and BMI (≥25, 18.5-25, and <18.5 kg/m²): metabolically healthy obesity (MHO), metabolically unhealthy obesity (MUO), metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy underweight (MHUW), and metabolically unhealthy underweight (MUUW). Mortality data were collected until 2020.</p><p><strong>Results: </strong>Among 8,838 patients with T1D (mean age 54.7 years, 60.6% male), the prevalence of MUUW, MHUW, MUNW, MHNW, MHO, and MUO was 1.1%, 3.0%, 28.5%, 31.2%, 6.3%, and 29.9%, respectively. Over a median 8.3-year follow-up, patients with MHO exhibited the lowest all-cause mortality risk (adjusted hazard ratio [aHR], 0.70; P = 0.007), and those with MUO also had a lower risk (aHR, 0.77; P < 0.001) compared with the MHNW group. Conversely, the underweight groups had significantly higher all-cause (MHUW: aHR, 2.08; MUUW: aHR, 3.94) and cardiovascular disease (CVD)-related mortalities (MHUW: aHR, 2.47; MUUW: aHR, 6.31). Patients with MHO had a lower risk of CVD (aHR, 0.76), whereas those with MUO, MUNW, and MUUW had increased risks (aHRs, 1.18, 1.32, and 2.22).</p><p><strong>Conclusions: </strong>Metabolic unhealthiness was associated with a higher CVD risk, and the risks of mortality and CVD were particularly high in patients with MUUW, underscoring the importance of maintaining metabolic health in T1D.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of three gestational weight gain guidelines for adverse pregnancy outcomes in Chinese women with gestational diabetes: A cohort study.","authors":"Shuang Zhang, Weiqin Li, Nan Li, Jia Guo, Linglin Tan, Huikun Liu","doi":"10.1111/jdi.70439","DOIUrl":"10.1111/jdi.70439","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the associations between post-diagnostic gestational weight gain (GWG) and adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM) and to systematically compare the predictive performance of three mainstream GWG guidelines (IOM-2009, CNS-2021, NHCC-2023), so as to provide real-world evidence for precise GWG management in clinical GDM care.</p><p><strong>Methods: </strong>This retrospective population-based study was conducted utilizing the standardized prenatal surveillance system in Tianjin, China. Women with GDM were stratified into insufficient, appropriate, and excessive GWG groups according to the IOM-2009, CNS-2021, and NHCC-2023 criteria. Independent associations of abnormal GWG with adverse perinatal outcomes were analyzed using independent t-tests, chi-squared tests, and multivariable logistic regression models in SPSS 26.0.</p><p><strong>Results: </strong>A total of 69,859 pregnant women were enrolled in the present study, including 7,198 women diagnosed with GDM. The NHCC-2023 guideline identified the highest proportion of excessive GWG (56.6%), compared with CNS-2021 (52.7%) and IOM-2009 (53.3%). Notably, only NHCC-2023 revealed a significant bidirectional association between GWG and PE risk: insufficient GWG (OR = 1.512, 95% CI: 1.057-2.162) and excessive GWG (OR = 2.449, 95% CI: 1.844-3.253) were both independently correlated with higher PE susceptibility. Excessive postdiagnostic GWG was associated with elevated risks of cesarean section and large for gestational age (LGA) infants across all three guideline frameworks, while associations for preterm birth and small-for-gestational-age (SGA) varied by guideline criteria.</p><p><strong>Conclusions: </strong>The GDM-specific NHCC-2023 guideline supports precise, population-tailored GWG management for Chinese women with GDM and holds promising clinical applicability for Asian GDM populations.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13620339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M1 macrophage-derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis.","authors":"Lei Li, Hongmei Liu, Yu Mao, Huanhuan Wang, Lige Song, Zhiqiang Kang","doi":"10.1111/jdi.70446","DOIUrl":"10.1111/jdi.70446","url":null,"abstract":"<p><strong>Background: </strong>Diabetic nephropathy (DN) is a severe microvascular complication of diabetes mellitus. The specific role of M1 macrophage-derived exosomes in DN progression remains largely unexplored.</p><p><strong>Methods: </strong>THP-1 monocytes were differentiated into M0 macrophages and polarized into M1 macrophages for exosome extraction. WTAP was silenced using shRNA to generate WTAP-deficient exosomes. Glomerular endothelial cells (GECs) were exposed to high glucose (HG) and co-incubated with modified exosomes. Cell viability, oxidative stress, apoptosis, barrier function, and angiogenic capacity were assessed. The WTAP-S1PR2 interaction was validated by RIP, MeRIP, and dual-luciferase assays. In vivo, db/db mice received tail vein injections of respective exosomes for 8 weeks, followed by assessments of renal function, histopathology, and inflammation.</p><p><strong>Results: </strong>M1 exosomes were internalized by GECs. WTAP delivered by shNC/M1-Exo bound S1PR2 mRNA, enhancing its m6A modification and stability, thereby activating the RhoA/ROCK1 axis and aggravating HG-induced GEC injury, oxidative stress, apoptosis, and endothelial permeability. Conversely, shWTAP/M1-Exo attenuated these effects, and S1PR2 overexpression reversed the protective effects. In vivo, shWTAP/M1-Exo improved renal function, ameliorated histopathological damage and fibrosis, and reduced systemic inflammation in db/db mice.</p><p><strong>Conclusion: </strong>M1 macrophage-derived exosomes promote DN progression by delivering WTAP to stabilize S1PR2 mRNA in an m6A-dependent manner. Engineered exosomes lacking WTAP represent a promising targeted nanomedicine strategy for DN treatment.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}