Journal of Diabetes Investigation最新文献

{"title":"No change in small low-density lipoprotein cholesterol levels with pemafibrate might explain the negative results of the PROMINENT trial","authors":"Tsutomu Hirano","doi":"10.1111/jdi.13983","DOIUrl":"https://doi.org/10.1111/jdi.13983","url":null,"abstract":"<p>To the Editor</p><p>The Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) trial was recently published in the <i>New England of Journal of Medicine</i>,<span>¹</span> and failed to show a preventive effect of pemafibrate on atherosclerotic cardiovascular disease (ASCVD) in patients with type 2 diabetes and dyslipidemia. This study was designed to determine whether pemafibrate, a triglyceride (TG)-lowering drug, can reduce the incidence of ASCVD in hypertriglyceridemic and low high-density lipoprotein cholesterol patients, whose low-density lipoprotein cholesterol (LDL-C) is controlled &lt;70 mg/dL with statins. As TG-rich lipoproteins (TRLs), especially its remnants, are considered to be atherogenic, like LDL, it was of interest to see if selective suppression of TRLs with pemafibrate would reduce CV events. The results showed that lowering TRL with pemafibrate did not lead to a reduction in CV events, suggesting that TRL does not play an important role in the development of atherosclerosis when LDL-C is tightly controlled. The results of this study will further solidify LDL's status as an unrivaled atherogenic lipoprotein.</p><p>LDL includes both large buoyant LDL and small density (sd) LDL particles, the latter of which are more atherogenic than the former. Recent large cohort studies showed that sdLDL-C is a powerful biomarker for ASCVD beyond LDL-C. It is well documented that sdLDL-C levels are substantially elevated in hypertriglyceridemic diabetes. As sdLDL-C is positively correlated with TG, pemafibrate treatment should reduce sdLDL-C by its TG-lowering effect. If so, why did the favorable change in LDL composition not lead to a reduction in CV events? Sampson <i>et al</i>.<span>²</span> proposed a formula for calculating sdLDL-C using LDL-C and TG as variables, based on our established direct sdLDL-C measurement.<span>³</span> They also showed that calculated sdLDL-C is a strong predictor of ASCVD.<span>³</span> As the PROMINENT study showed actual values of TG, total-C and high-density lipoprotein cholesterol at baseline, and 4 and 12 months,<span>¹</span> sdLDL-C can be calculated. Table 1 shows calculated sdLDL-C in the PROMINENT study. Surprisingly, sdLDL-C levels were almost identical in the pemafibrate and placebo groups. This is supported by the fact that levels of non-high-density lipoprotein cholesterol and apolipoprotein B, known as surrogate markers for sdLDL-C, were not reduced by pemafibrate.<span>¹</span> In the phase III study, pemafibrate alone or in combination with pemafibrate and a statin reduced the sdLDL fraction, but in the PROMINENT study, pemafibrate did not reduce the calculated value of sdLDL-C. A possible reason for this is that most participants in the phase III study had higher baseline LDL-C concentrations than in the PROMINENT trial, in which most participants received intensive st","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 4","pages":"630-631"},"PeriodicalIF":3.2,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5847479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update information on type 1 diabetes in children/adolescents and adults","authors":"Junnosuke Miura,&nbsp;Yasuko Uchigata","doi":"10.1111/jdi.13961","DOIUrl":"https://doi.org/10.1111/jdi.13961","url":null,"abstract":"<p>In 2000, the world's age-adjusted prevalence of type 1 diabetes with onset under 15 years was reported using data from 1990 to 1994<span>¹</span>. The lowest incidence rate (/10⁵ person-years) was 0.1 in China and Venezuela, and the highest was 36.8 in Sardinia and 36.5 in Finland; revealing a difference of more than 350-fold between the lowest and highest incidence rates. Other high-incidence countries included Sweden, Norway, Canada, the United Kingdom, and New Zealand. East Asia belonged to the low incidence group, and Japan had an incidence rate of 1.1–2.2. In Asia and Africa, with an overall low incidence rate, the incidence rate is high in girls, while in Europe and the United States, with an overall high incidence rate, it is the same or higher in boys<span>²</span>. Different reasons have been proposed for this discrepancy including genetics, racial differences, epidemiological sampling problems, autoimmunity, and pregnancy; however, the mechanism of this discrepancy is not completely understood.</p><p>The 2021 International Diabetes Federation (IDF) Atlas 10th edition<span>³</span> published an estimate of 108,300 (149,500) annual new-onset type 1 diabetes cases under 15 years of age (under 20 years of age). The estimated prevalence was 651,700 (1,211,900), and compared with previous IDF Atlas estimates, there has been an increase in the incidence in many IDF regions. The reasons for this increase in incidence have been not clear, but in addition to the presence of susceptible genomic background in type 1 diabetes, environmental factors including changes milk intake, exposure to heterologous proteins from early birth, and rapid postnatal growth have been proposed to be associated with an increased incidence of type 1 diabetes. Furthermore, lifestyle changes, including a decrease in the morbidity of infectious diseases, have been proposed to affect the incidence of type 1 diabetes. Furthermore, lifestyle changes, including a decrease in the morbidity of infectious diseases, have been proposed to affect the incidence of type 1 diabetes. The male-to-female ratio of incidence in the countries and regions, described in the previous paragraph, has not changed significantly from the previous state.</p><p>From the end of 2019, it was reported that Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-Cov-2) infection spread worldwide and caused various symptoms. It has been reported that the incidence of childhood-onset type 1 diabetes increased after SARS-Cov-2 infection<span>^{4, 5}</span>. Additionally, there are some reports of type 1 diabetes developing after vaccination against Coronavirus disease (COVID)-19<span>^6-8</span>. However, currently it is impossible to clarify the causal relationship between the COVID-19 ribonucleic acid (RNA)-based vaccine and the onset of type 1 diabetes. As the relationship between the Coxsackie virus and the onset of type 1 diabetes has been r","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 4","pages":"531-534"},"PeriodicalIF":3.2,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13961","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5729216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in genetics of type 2 diabetes and diabetic complications","authors":"Nobuhiro Shojima,&nbsp;Toshimasa Yamauchi","doi":"10.1111/jdi.13970","DOIUrl":"https://doi.org/10.1111/jdi.13970","url":null,"abstract":"<p>Type 2 diabetes results from a complex interaction between genetic and environmental factors. Precision medicine for type 2 diabetes using genetic data is expected to predict the risk of developing diabetes and complications and to predict the effects of medications and life-style intervention more accurately for individuals. Genome-wide association studies (GWAS) have been conducted in European and Asian populations and new genetic loci have been identified that modulate the risk of developing type 2 diabetes. Novel loci were discovered by GWAS in diabetic complications with increasing sample sizes. Large-scale genome-wide association analysis and polygenic risk scores using biobank information is making it possible to predict the development of type 2 diabetes. In the ADVANCE clinical trial of type 2 diabetes, a multi-polygenic risk score was useful to predict diabetic complications and their response to treatment. Proteomics and metabolomics studies have been conducted and have revealed the associations between type 2 diabetes and inflammatory signals and amino acid synthesis. Using multi-omics analysis, comprehensive molecular mechanisms have been elucidated to guide the development of targeted therapy for type 2 diabetes and diabetic complications.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 4","pages":"503-515"},"PeriodicalIF":3.2,"publicationDate":"2023-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5847102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and the strategy for remission of type 2 diabetes mellitus","authors":"Tien-Jyun Chang","doi":"10.1111/jdi.13948","DOIUrl":"https://doi.org/10.1111/jdi.13948","url":null,"abstract":"<p>Type 2 diabetes is no longer seen as being an irreversible natural course, accompanied by progressive beta cell failure and various chronic diabetes related complications. In contrast, remission can be achieved through a personalized approach. It is a paradigm shift in our understanding of type 2 diabetes and it may be necessary to change the concept of type 2 diabetes as an urgent condition requiring rapid intervention rather than a chronic progressive disease.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 3","pages":"351-353"},"PeriodicalIF":3.2,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6187238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective properties of DPP-4i: A therapeutic target for dementia prevention in elderly diabetic patients?","authors":"Toshitaka Umemura,&nbsp;Takahiko Kawamura","doi":"10.1111/jdi.13972","DOIUrl":"https://doi.org/10.1111/jdi.13972","url":null,"abstract":"<p>Possible mechanisms of Alzheimer's disease-related cognitive impairment in patients with diabetes mellitus are shown in this figure. DPP-4i may modulate Aβ accumulation in the process of AD-related cognitive impairment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 4","pages":"525-527"},"PeriodicalIF":3.2,"publicationDate":"2023-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13972","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5759055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intensive lifestyle intervention on the association between weight variability and major adverse cardiovascular events in overweight or obese adults with type 2 diabetes mellitus","authors":"Xiangbin Zhong,&nbsp;Xingfeng Xu,&nbsp;Menghui Liu,&nbsp;Peng Wang,&nbsp;Lixiang He,&nbsp;Odong Christopher,&nbsp;Shaozhao Zhang,&nbsp;Yifen Lin,&nbsp;Yiquan Huang,&nbsp;Zhenyu Xiong,&nbsp;Xiaodong Zhuang,&nbsp;Xinxue Liao","doi":"10.1111/jdi.13964","DOIUrl":"https://doi.org/10.1111/jdi.13964","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/introduction</h3>\u0000 \u0000 <p>Weight variability is associated with cardiovascular outcomes in diabetic patients. However, whether the guideline-recommended intensive lifestyle intervention (ILI) will affect this association in overweight or obese adults with diabetes is not well established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In 3,859 participants from the Action for Health in Diabetes (Look AHEAD) trial, the associations of 4 year weight variability measured by variability independent of the mean (VIM) with major adverse cardiovascular event (MACE) and secondary outcomes in ILI and diabetes support &amp; education (DSE) arm were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During a median follow-up of 9.6 years, 255 (12.9%) participants in the ILI arm and 247 (13.2%) participants in the DSE arm developed MACE. Participants with the highest quartile of weight variability (VIM Q4) experienced a 2.23-fold higher risk of MACE compared with the lowest quartile (VIM Q1) in the DSE arm (hazard ratio [HR] 2.23; 95% CI 1.51–3.30). Compared with the lowest weight variability (VIM Q1), participants with the highest weight variability (VIM Q4) were associated with higher risks of secondary cardiovascular composite outcome (HR 1.88; 95% CI 1.20–2.95), all-cause mortality (HR 3.19; 95% CI 1.75–5.82), and myocardial infarction (HR 1.95; 95% CI 1.12–3.37) in the DSE arm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Among the overweight or obese individuals with type 2 diabetes mellitus, rising weight variability was independently associated with increased MACE risks in the DSE arm. Therefore, a guideline-recommended ILI strategy for weight loss should be adopted to improve cardiovascular outcomes without worrying about the effect of weight fluctuations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 3","pages":"441-451"},"PeriodicalIF":3.2,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13964","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6102025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA TCF7 contributes to high glucose-induced damage in human podocytes by up-regulating SEMA3A via sponging miR-16-5p","authors":"Zhenzhen Jiang,&nbsp;Lijie Qian,&nbsp;Ruifeng Yang,&nbsp;Yan Wu,&nbsp;Yongping Guo,&nbsp;Tingfang Chen","doi":"10.1111/jdi.13904","DOIUrl":"https://doi.org/10.1111/jdi.13904","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Long non-coding RNAs (lncRNAs) exert essential functions in the pathogenesis of diabetic nephropathy (DN). LncRNA T-cell factor 7 (TCF7) and semaphorin-3A (SEMA3A) have been found to be involved in the progression of diabetic nephropathy. However, whether the effect of TCF7 on the pathogenesis of diabetic nephropathy is mediated by SEMA3A remains unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>TCF7, miR-16-5p, and SEMA3A were quantified by a qRT-PCR or immunoblotting method. A CCK-8 assay gauged the cell viability. Measurement of cell apoptosis was done using flow cytometry. RNA immunoprecipitation (RIP), dual-luciferase reporter, and RNA pull-down assays were utilized to assay the targeted interactions among the variables.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The TCF7 and SEMA3A levels were elevated in serum from patients with diabetic nephropathy. TCF7 silencing or SEMA3A depletion ameliorated high glucose (HG)-induced podocyte injury. Moreover, TCF7 silencing protected against HG-induced podocyte injury by down-regulating SEMA3A. TCF7 targeted miR-16-5p, and miR-16-5p targeted SEMA3A. Furthermore, TCF7 affected the expression of SEMA3A by competing specifically for shared miR-16-5p.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggested that TCF7 silencing attenuated high glucose-induced podocyte damage partially through the miR-16-5p/SEMA3A regulation cascade.</p>\u0000 </section>\u0000 </div>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 2","pages":"193-204"},"PeriodicalIF":3.2,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5768112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting pancreatic β cell proliferation: A powerful key for realizing regenerative therapy for diabetes","authors":"Yukihiro Shimaya,&nbsp;Nobuaki Shiraki,&nbsp;Shoen Kume","doi":"10.1111/jdi.13967","DOIUrl":"https://doi.org/10.1111/jdi.13967","url":null,"abstract":"<p>This commentary is on a recent report on the regulation mechanism of beta cell proliferation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 4","pages":"522-524"},"PeriodicalIF":3.2,"publicationDate":"2022-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6066079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of different eating patterns in the management of type 2 diabetes and prediabetes: An arm-based Bayesian network meta-analysis","authors":"Ben-tuo Zeng,&nbsp;Hui-qing Pan,&nbsp;Feng-dan Li,&nbsp;Zhen-yu Ye,&nbsp;Yang Liu,&nbsp;Ji-wei Du","doi":"10.1111/jdi.13935","DOIUrl":"https://doi.org/10.1111/jdi.13935","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Diet therapy is a vital approach to manage type 2 diabetes and prediabetes. However, the comparative efficacy of different eating patterns is not clear enough. We aimed to compare the efficacy of various eating patterns for glycemic control, anthropometrics, and serum lipid profiles in the management of type 2 diabetes and prediabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>We conducted a network meta-analysis using arm-based Bayesian methods and random effect models, and drew the conclusions using the partially contextualized framework. We searched twelve databases and yielded 9,534 related references, where 107 studies were eligible, comprising 8,909 participants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eleven diets were evaluated for 14 outcomes. Caloric restriction was ranked as the best pattern for weight loss (SUCRA 86.8%) and waist circumference (82.2%), low-carbohydrate diets for body mass index (81.6%), and high-density lipoprotein (84.0%), and low-glycemic-index diets for total cholesterol (87.5%) and low-density lipoprotein (86.6%). Other interventions showed some superiorities, but were imprecise due to insufficient participants and needed further investigation. The attrition rates of interventions were similar. Meta-regression suggested that macronutrients, energy intake, and weight may modify outcomes differently. The evidence was of moderate-to-low quality, and 38.2% of the evidence items met the minimal clinically important differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The selection and development of dietary strategies for diabetic/prediabetic patients should depend on their holistic conditions, i.e., serum lipid profiles, glucometabolic patterns, weight, and blood pressure. It is recommended to identify the most critical and urgent metabolic indicator to control for one specific patient, and then choose the most appropriate eating pattern accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 2","pages":"263-288"},"PeriodicalIF":3.2,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5831396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of hepatitis B virus on the prevalence of diabetes complications in patients with type 2 diabetes","authors":"Xi-yu Liu,&nbsp;Yan Zhou","doi":"10.1111/jdi.13954","DOIUrl":"https://doi.org/10.1111/jdi.13954","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims/Introduction</h3>\u0000 \u0000 <p>Diabetes and hepatitis B are both global problems. The influence of diabetes on complications and prognosis of hepatitis B has been widely studied. However, the association between hepatitis B virus (HBV) infection and the prevalence of diabetes-related complications is less documented and is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This was a retrospective study. We collected information from a large clinical database. A total of 1,090 Chinese inpatients with type 2 diabetes were included.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The participants were divided into two groups, including 135 patients with HBV infection and 955 patients without HBV infection. Patients with HBV infection were younger and had worse control of blood glucose than those without HBV infection. No significant difference was found in the prevalence of diabetic retinopathy, neuropathy, nephropathy, diabetic ketosis or diabetic ketoacidosis between the patients with HBV infection and the patients without HBV infection. The prevalence of macrovascular complications was 54.1% and 64.4% in diabetes patients complicated with HBV infection and without HBV infection, respectively. The <i>P</i>-value was &lt;0.05. However, through the logistic regression analysis, we found HBV infection was not an independent risk factor for macrovascular complications of diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was no significant correlation between the prevalence of macrovascular complications, microvascular complications of diabetes, diabetic ketosis or diabetic ketoacidosis and HBV infection status.</p>\u0000 </section>\u0000 </div>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":"14 3","pages":"429-434"},"PeriodicalIF":3.2,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jdi.13954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5820337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}