Comparative disease burden of early-onset and late-onset type 2 diabetes in the U.S.: Evidence from NHANES 2003-2018.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-25 DOI:10.1111/jdi.70096

Shuoying Yue, Meng Su, Zihao Zhang, Zhiyi Hao, Man Li, Liang Zhang, Naijian Zhang, Zhilin Li, Qingcui Wu, Huijie Huang, Honglu Zhang, Yuanyuan Liu, Hui Wang, Jun Ma

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引用次数: 0

Abstract

Objective: To estimate the disease burden of type 2 diabetes (T2D) in early-onset (age < 40) and late-onset (age ≥ 40) in the U.S.

Methods: Data obtained from the National Health and Nutrition Examination Survey 2003-2018. Prevalence, number, and disability-adjusted life years (DALYs) in early-onset and late-onset T2D were assessed.

Results: There was a clear and steady upward trend in early-onset T2D, although the prevalence and number of late-onset T2D were higher than early-onset. The average loss of DALYs per capita (DALYs/per) in the early-onset T2D was higher than that in the late-onset. DALYs/per is higher in males than females in both early- and late-onset T2D groups. People living at or below the poverty line and those with education of high school and below had a higher DALYs/per of early-onset T2D. Among individuals with early-onset T2D, the DALYs/per loss was higher in the non-obesity group.

Conclusion: There was a clear upward trend in the prevalence of early-onset T2D, and the loss of DALYs/per in early-onset T2D was higher than that in late-onset T2D. The attribution risk factors, like sex, education levels, income levels, and body mass index, for the burden of early-onset T2D varied, and measures need to be taken to target different populations.

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美国早发型和晚发型2型糖尿病的比较疾病负担：来自NHANES 2003-2018的证据

目的：估计早发2型糖尿病（T2D）患者的疾病负担。方法：数据来自2003-2018年全国健康与营养检查调查。评估早发性和晚发性T2D的患病率、数量和残疾调整生命年（DALYs）。结果：早发性T2D呈明显而稳定的上升趋势，但晚发性T2D患病率和数量均高于早发性T2D。早发性T2D的人均平均DALYs损失（DALYs/per）高于晚发性T2D。在早发性和晚发性T2D组中，男性的DALYs/per高于女性。生活在贫困线以下和高中及以下学历的人早发性T2D的DALYs/per较高。在早发性T2D患者中，非肥胖组的DALYs/per损失更高。结论：早发性T2D患病率有明显上升趋势，且早发性T2D的DALYs/per损失高于晚发性T2D。性别、受教育程度、收入水平、体重指数等对早发性T2D负担的归因风险因素存在差异，需要针对不同人群采取相应措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).