Journal of Diabetes Investigation最新文献_第3页

Impact of lifestyle on diabetic nephropathy in aged 18-64 years: A population-based cross-sectional analysis from NHANES 2007-2018. 生活方式对18-64岁糖尿病肾病的影响：NHANES 2007-2018基于人群的横断面分析

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-09 DOI: 10.1111/jdi.70069

Zhijun Zhang, Zhaoyinling Wei, Ling Gao

{"title":"Impact of lifestyle on diabetic nephropathy in aged 18-64 years: A population-based cross-sectional analysis from NHANES 2007-2018.","authors":"Zhijun Zhang, Zhaoyinling Wei, Ling Gao","doi":"10.1111/jdi.70069","DOIUrl":"https://doi.org/10.1111/jdi.70069","url":null,"abstract":"Background: The relationship between lifestyle and overall health has garnered significant attention. This study aimed to evaluate the association between lifestyle factors and diabetic nephropathy (DN) in adults aged 18-64 years.Materials and methods: We conducted a cross-sectional study involving 2,389 participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). The use of the Healthy Eating Index (HEI), Metabolic Equivalent of Task (MET), sleeping duration, smoking, and drinking status as indicators to assess lifestyle. Logistic regression analyses and restricted cubic splines were used to analyze the results. A subgroup analysis was performed to identify any variations.Results: Logistic regression analysis indicates that poor HEI and sleep duration but not physical activity are associated with an increased risk of DN. Subgroup analyses revealed significant interactions between HEI and age, blood pressure, HbA1c, and lipid control; MET interacted with blood pressure and HbA1c control; Sleeping duration interacted with age, smoking, blood pressure, HbA1c, and lipid control; Smoking interacted with age, blood pressure control, and lipid control; Drinking interacted with blood pressure control. Moreover, restricted cubic splines indicated that with increasing HEI, the prevalence of DN tended to decrease. However, the associations between the other two lifestyle factors (MET level and sleeping duration) and DN were all U-shaped.Conclusions: Lifestyle factors are closely associated with diabetic nephropathy. Both unhealthy eating habits and inadequate or excessive sleeping duration and physical activity contribute to an increased risk of diabetic nephropathy, whereas no statistically significant association is observed in smoking and drinking.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Effectiveness of tele-guidance for physiotherapy in older patients with type 2 diabetes: A randomized controlled trial". 对“远程指导老年2型糖尿病患者物理治疗的有效性：一项随机对照试验”的评论。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-08 DOI: 10.1111/jdi.70070

Ying Zhou, Heyi Yuan, Yan Shi

引用次数: 0

Clinical features of overt versus diagnosed pre-existing diabetes in pregnancy. 妊娠期显性糖尿病与确诊糖尿病的临床特征。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-08 DOI: 10.1111/jdi.70045

Kei Fujikawa Shingu, Masako Waguri, Mitsuyoshi Takahara, Naoto Katakami, Iichiro Shimomura

引用次数: 0

Hypoglycemic timeslots after hospital discharge in patients with diabetes on multiple daily insulin injection: Dose of Insulin CHanged According to the Reported Glucose by Libre Pro (DISCHARGe study). 每日多次胰岛素注射的糖尿病患者出院后的低血糖时段：根据Libre Pro报告的血糖变化胰岛素剂量（出院研究）

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-08 DOI: 10.1111/jdi.70065

Manabu Saito, Hiroshi Uchino, Ayako Fuchigami, Genki Sato, Masahiko Miyagi, Takahisa Hirose

{"title":"Hypoglycemic timeslots after hospital discharge in patients with diabetes on multiple daily insulin injection: Dose of Insulin CHanged According to the Reported Glucose by Libre Pro (DISCHARGe study).","authors":"Manabu Saito, Hiroshi Uchino, Ayako Fuchigami, Genki Sato, Masahiko Miyagi, Takahisa Hirose","doi":"10.1111/jdi.70065","DOIUrl":"https://doi.org/10.1111/jdi.70065","url":null,"abstract":"Introduction: Insulin improves clinical outcomes in hospitalized patients; however, hypoglycemia hinders discharge transition in patients with insulin-treated diabetes. Studies on hypoglycemic timeslots, rates, and risk factors during discharge transition are lacking.Materials and methods: Fifteen patients with type 2 diabetes (T2D) receiving multiple daily insulin (MDI) injections participated. Glucose variability metrics and hypoglycemia were monitored using a continuous glucose monitoring system starting a day pre-discharge through 13 days of discharge transition. Hypoglycemia was analyzed chronobiologically using Cosinor analysis. Anthropometric measurements, C-peptide, insulin dose, and glucagon were assessed.Results: The mean patient age was 52.7 ± 12.6 years; 13/15 were male; body mass index was 28.1 ± 5.9 kg/m2, T2D duration was 8.6 ± 8.8 years, HbA1c was 12.4 ± 2.5%, and total daily insulin dose averaged 36.6 ± 15.1 units and hospitalization lasted 13.1 ± 2.3 days. Time in range decreased post-discharge. Time below range increased from 7.0% at discharge to 17.6% by the study end (manova, P < 0.001). Hypoglycemic events peaked post-breakfast, with the highest amplitude (42 points) recorded at 12:00. The highest and lowest numbers of hypoglycemia occurred at 12:00 and 17:30, respectively. However, the highest hypoglycemic timeslot (11:00-12:00) was not significantly associated with clinical and biochemical parameters.Conclusions: The chronobiology of hypoglycemia exists during the discharge transition in patients with MDI-treated T2D. Hypoglycemia frequency and severity peaked pre-lunch, reached a nadir at 17:30, and exaggerated post-discharge, emphasizing the need for pre-breakfast insulin dose reductions on the discharge day.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in cause of death and age at death between people with and without diabetes over 10 years (2010-2020): A cross-sectional study in Japan. 10年以上（2010-2020年）糖尿病患者和非糖尿病患者死亡原因和死亡年龄的差异：日本的一项横断面研究

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-08 DOI: 10.1111/jdi.70067

Hirofumi Sugimoto, Noriko Ihana-Sugiyama, Takehiro Sugiyama, Noriko Kodani, Ryotaro Bouchi, Mitsuru Ohsugi, Kohjiro Ueki, Hiroshi Kajio

{"title":"Differences in cause of death and age at death between people with and without diabetes over 10 years (2010-2020): A cross-sectional study in Japan.","authors":"Hirofumi Sugimoto, Noriko Ihana-Sugiyama, Takehiro Sugiyama, Noriko Kodani, Ryotaro Bouchi, Mitsuru Ohsugi, Kohjiro Ueki, Hiroshi Kajio","doi":"10.1111/jdi.70067","DOIUrl":"https://doi.org/10.1111/jdi.70067","url":null,"abstract":"Aims/introduction: Investigating the causes of death in individuals with diabetes compared with those without is essential for understanding diabetes care. However, methods for identifying individuals with diabetes within populations vary. We conducted a comparison of these groups under identical conditions, analyzing differences in causes and age at death, and assessing how different identification methods influence these outcomes.Materials and methods: This study used the clinical records of inpatients who died at the National Center for Global Health and Medicine from September 1, 2010, to December 31, 2020. Individuals with or without diabetes were defined using prescriptions and laboratory data. The cause of death was determined by the name of the primary illness provided by the attending physician at the time of death. Individuals with diabetes were stratified by different definitions, and their age at death was compared.Results: In Individuals with diabetes, males accounted for 67.6%, and in those without diabetes, 57.0%. The mean age at death was 75.0 ± 11.8 and 73.8 ± 16.0 years, respectively. Malignant neoplasia was the most common cause of death in both groups, with a higher frequency in individuals with diabetes (36.9% vs 31.0%). Age at death of individuals with diabetes differed by up to 1.5 years, depending on the definitions.Conclusions: Direct comparisons suggested that malignant neoplasia was the leading cause of death, and individuals with diabetes had a higher mean age at death. The method used to identify diabetes influenced these outcomes, emphasizing the importance of careful consideration in mortality studies.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipocyte exosome miR-4472 inhibits glucose uptake in skeletal muscle through downregulation of MEF2D. 脂肪细胞外泌体miR-4472通过下调MEF2D抑制骨骼肌的葡萄糖摄取。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-08 DOI: 10.1111/jdi.70054

Chaoyue Sun, Xin Wen, Xiaolong Chu, Fangyuan Yuan, Yao Chen, Chaoling Peng, Meiyu Qian, Jin Mei, Juan Wang, Yidan Jiang, Shibo Xu, Cuizhe Wang, Wei Li, Jun Zhang

{"title":"Adipocyte exosome miR-4472 inhibits glucose uptake in skeletal muscle through downregulation of MEF2D.","authors":"Chaoyue Sun, Xin Wen, Xiaolong Chu, Fangyuan Yuan, Yao Chen, Chaoling Peng, Meiyu Qian, Jin Mei, Juan Wang, Yidan Jiang, Shibo Xu, Cuizhe Wang, Wei Li, Jun Zhang","doi":"10.1111/jdi.70054","DOIUrl":"https://doi.org/10.1111/jdi.70054","url":null,"abstract":"Aims/introduction: Previous studies have found that miR-4472 is overexpressed in the serum of individuals with obesity and type 2 diabetes mellitus (T2DM), which may participate in the process of obesity-induced T2DM. However, a role for miR-4472 in the process has not been demonstrated. Here, we aim to investigate whether the increased content of miR-4472 in adipose tissue derived from exosomes inhibits glucose uptake in skeletal muscle by downregulating the expression of its target gene.Materials and methods: In vitro C2C12 and 3T3-L1 cells, and in vivo diet-induced obesity mouse models and AT-Dicer KO mice were used to assess the impact of miR-4472 on glucose uptake and insulin sensitivity. We also evaluated the effects of serum exosomes from normal and obese individuals on insulin sensitivity in mice and the expression of miR-4472 and target genes in skeletal muscle.Results: miR-4472 exhibits a strong positive correlation with BMI, waist circumference, hip circumference, and FPG. The content of miR-4472 derived from adipose tissue exosomes increases in the circulation in a state of obesity, which can induce insulin resistance by targeting the expression of MEF2D/GLUT4, inhibiting the glucose consumption and uptake ability of skeletal muscle cells. Both exosome inhibitors and miR-4472 inhibitors can reverse the inhibitory effect of miR-4472 on MEF2D/GLUT4 expression and glucose intake and uptake ability. Additionally, they can improve insulin resistance caused by increased miR-4472 levels in mice with obesity.Conclusions: Adipocyte exosome miR-4472 inhibits glucose uptake in skeletal muscle through downregulating the expression of MEF2D/GLUT4.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver function effects of SGLT2 inhibitor and GLP-1 receptor agonist combination treatment in patients with type 2 diabetes (post hoc analysis of RECAP study). SGLT2抑制剂和GLP-1受体激动剂联合治疗对2型糖尿病患者肝功能的影响（RECAP研究的事后分析）

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-07 DOI: 10.1111/jdi.70066

Daisuke Tsuriya, Kazuo Kobayashi, Kei Takeshita, Takuya Hashimoto, Moritsugu Kimura, Yoshimi Muta, Hisashi Yokomizo, Yuichi Takashi, Shunichiro Tsukamoto, Kouichi Tamura, Keizo Kanasaki, Daiji Kawanami, Masao Toyoda

{"title":"Liver function effects of SGLT2 inhibitor and GLP-1 receptor agonist combination treatment in patients with type 2 diabetes (post hoc analysis of RECAP study).","authors":"Daisuke Tsuriya, Kazuo Kobayashi, Kei Takeshita, Takuya Hashimoto, Moritsugu Kimura, Yoshimi Muta, Hisashi Yokomizo, Yuichi Takashi, Shunichiro Tsukamoto, Kouichi Tamura, Keizo Kanasaki, Daiji Kawanami, Masao Toyoda","doi":"10.1111/jdi.70066","DOIUrl":"https://doi.org/10.1111/jdi.70066","url":null,"abstract":"Aim: The favor effect on liver disease by odium-glucose cotransporter inhibitor (SGLT2i) and GLP-1 receptor agonist (GLP1Ra) was reported; however, the effect of the combination treatment of these drugs was not well known.Methods: We retrospectively analyzed data for 643 patients with type 2 diabetes receiving SGLT2i + GLP1Ra combination treatment for at least 1 year (331 and 312 patients in the GLP1Ra- and SGLT2i-preceding groups, respectively). Propensity score (PS) matching was used to compare the effects of the preceding drugs on liver function.Results: The mean AST and ALT values at baseline, at the initiation of combination treatment, and at final observation were 29.8 ± 20.0 and 37.7 ± 29.5, 28.7 ± 17.3 and 35.3 ± 6.0, 26.0 ± 14.6 and 30.1 ± 21.6 IU/L, respectively, indicative of significant improvements in liver function (P < 0.001). Conversely, significant progress in the fibrosis-4 (FIB-4) index category was observed even after the combination treatment (P = 0.03). Subgroup analysis revealed that a significant decrease in ALT was observed only in patients with a baseline ALT ≥30 IU/L after the combination treatment (P = 0.005). Improvement of the FIB-4 index category was observed in patients in the baseline FIB-4 index ≥2.6 group and in the 1.3 ≤FIB-4 index <2.6 group (46% and 19%, respectively). The matched model showed no significant differences in liver function after combination treatment between the SGLT2i- and GLP1Ra-preceding groups.Conclusions: SGLT2i + GLP1Ra combination treatment significantly improved liver dysfunction and prevented the progression of FIB-4 index category among patients with an FIB-4 index ≥1.3.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the thrifty substrate hypothesis: Ketone bodies as cardioprotective fuels in diabetes and SGLT2 inhibitor therapy. 重新审视节俭底物假说：酮体在糖尿病和SGLT2抑制剂治疗中作为心脏保护燃料。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-07 DOI: 10.1111/jdi.70068

Yoriyasu Suzuki, Tetsuya Amano

引用次数: 0

Construction and validation of nomogram prediction model for ketoacidosis in elderly diabetic patients based on baseline data and glycolipid metabolism. 基于基线数据和糖脂代谢的老年糖尿病酮症酸中毒nomogram预测模型的构建与验证

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-07 DOI: 10.1111/jdi.70058

Aijin Niu, Jing Zhuang, Yangdi Li, Wei Wei

{"title":"Construction and validation of nomogram prediction model for ketoacidosis in elderly diabetic patients based on baseline data and glycolipid metabolism.","authors":"Aijin Niu, Jing Zhuang, Yangdi Li, Wei Wei","doi":"10.1111/jdi.70058","DOIUrl":"https://doi.org/10.1111/jdi.70058","url":null,"abstract":"Objective: To explore the risk factors of ketoacidosis (DKA) in elderly patients with diabetes and to construct a nomogram prediction model to guide clinical practice.Methods: Baseline, glycolipid metabolism, and related data were collected. Risk factors were screened by multifactor logistic regression analysis to construct a model. The effectiveness of the model was evaluated by Receiver Operating Characteristiv (ROC) curve, calibration curve analysis, and decision curve analysis (DCA).Results: Logistic regression analysis showed that age, duration of diabetes, FBG, 2hPG, HbA1c, TG, TC, and C peptide level were the independent risk factors for DKA in elderly diabetic patients (P < 0.05). The nomogram prediction model constructed based on these factors showed good prediction performance in both the training set and the verification set, with the C-index indexes being 0.880 and 0.918, respectively, and the average absolute errors of coincidence between the predicted value and the true value being 0.102 and 0.075, respectively. The results of the Hosmer-Lemeshow test were χ2 = 12.750, P = 0.120 and χ2 = 8.325, P = 0.402, respectively. The ROC curve showed that the AUC of the nomogram model in the training set and the verification set for predicting the occurrence of DKA in elderly diabetic patients was 0.866 and 0.879, respectively.Conclusion: Nomogram prediction model based on baseline data and glucose and lipid metabolism indicators showed good prediction efficiency in both the training set and the verification set. Age, diabetes duration, FBG, 2hPG, HbA1c, TG, TC, and C peptide levels were independent risk factors for DKA in elderly diabetic patients.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population. 肠道菌群与2型糖尿病的关系：与日本人群的疾病和缓解有关

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-05-07 DOI: 10.1111/jdi.70061

Keita Kinoshita, Naoki Ozato, Tohru Yamaguchi, Kenta Mori, Yoshihisa Katsuragi, Noriaki Sato, Seiya Imoto, Kazushige Ihara, Koichi Murashita, Shigeyuki Nakaji, Tatsuya Mikami

{"title":"Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population.","authors":"Keita Kinoshita, Naoki Ozato, Tohru Yamaguchi, Kenta Mori, Yoshihisa Katsuragi, Noriaki Sato, Seiya Imoto, Kazushige Ihara, Koichi Murashita, Shigeyuki Nakaji, Tatsuya Mikami","doi":"10.1111/jdi.70061","DOIUrl":"https://doi.org/10.1111/jdi.70061","url":null,"abstract":"Background: Although the gut microbiota is associated with type 2 diabetes (T2D) and its remission in clinical settings, their relationship in the general population remains unclear. This study aimed to investigate the association between the gut microbiota and T2D and its remission in a population-based setting.Methods: A cross-sectional study was conducted on 1,639 Japanese participants with (n = 106) or without (n = 1,533) T2D. The gut microbiota was compared between the two groups using multivariable-adjusted logistic regression. The relative abundance of the gut microbiota in fecal samples was calculated using 16S ribosomal RNA amplification. The association between the gut microbiota and T2D remission was determined via longitudinal analyses.Results: Six genera were independently associated with T2D; a higher abundance of Faecalibacterium, Blautia, Roseburia, and Oscillibacter was significantly associated with a lower odds ratio for T2D, whereas a higher abundance of Megasphaera and Lactobacillus was significantly associated with a higher odds ratio for T2D. Of these, only Blautia abundance was significantly increased in the remission group compared with that in the non-remission group. In the remission group, an increase in Blautia abundance was significantly correlated with an increase in adiponectin level and skeletal muscle mass.Conclusions: Specific gut microbes were significantly associated with T2D and its remission. The gut microbiota may represent a potential area for further exploration in T2D treatment and prevention. However, additional large-scale cohort studies or intervention studies using a probiotic or prebiotic approach are needed to validate these findings.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0