Journal of Diabetes Investigation最新文献_第3页

Construction of a metabolic-immune model for predicting the risk of diabetic nephropathy and study of gut microbiota.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-03 DOI: 10.1111/jdi.14401

Mengting Dai, Jianbo Wu, Zhaoyang Ji, Ping Chen, Chengchen Yang, Jialu Luo, Pengfei Shan, Mingzhi Xu

{"title":"Construction of a metabolic-immune model for predicting the risk of diabetic nephropathy and study of gut microbiota.","authors":"Mengting Dai, Jianbo Wu, Zhaoyang Ji, Ping Chen, Chengchen Yang, Jialu Luo, Pengfei Shan, Mingzhi Xu","doi":"10.1111/jdi.14401","DOIUrl":"https://doi.org/10.1111/jdi.14401","url":null,"abstract":"Aims: This study conducts a comprehensive analysis of the relative impact of risk factors for diabetic nephropathy (DN) during disease progression, with a particular emphasis on the role of gut microbiota. We developed multiple predictive models trying to enhance the early identification of high-risk patients in clinical practice.Materials and methods: We collected data from type 2 diabetes mellitus patients, categorizing them by renal function for comparison. Logistic regression identified risk factors for DN, and we developed nomogram and random forest risk prediction models. Finally, we analyzed the correlations among these factors.Results: Compared to patients with diabetes alone, those with DN have a longer disease duration, characterized by abdominal obesity, hypertension, chronic inflammation, activation of the complement system, and declining renal function, along with a significant reduction in Bifidobacterium and Enterobacterium. Patients with macroalbuminuria exhibit a higher male prevalence, as well as elevated blood pressure and lipid levels, and poorer renal function. Increased waist-to-hip ratio, systolic blood pressure, urea, neutrophil-to-lymphocyte ratio, and complement C3, along with decreased Enterobacterium and albumin, have been identified as significant risk factors for DN. The nomogram model developed based on these findings demonstrates good predictive capacity. And the establishment of the random forest model further underscores the importance of the aforementioned indicators. Additionally, significant correlations were observed among obesity, inflammation, blood pressure, lipid levels, and gut microbiota.Conclusions: Dysbiosis, metabolic disorders, and chronic inflammation play key roles in the progression of DN and may serve as new targets for future prevention and treatment strategies.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Commentary on 'Diminished levels of insulin-like growth factor-1 may be a risk factor for peripheral neuropathy in type 2 diabetes patients'.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-03 DOI: 10.1111/jdi.70017

Jingyi Zhong, Xiaopu Lin, Xiaobin Zheng, Yanting Zhou, Haishan Huang, Lingling Xu

引用次数: 0

Ginsenoside Rg1 inhibits angiogenesis in diabetic retinopathy through the miR-100-3p/FBXW7/c-MYC molecular axis.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-03 DOI: 10.1111/jdi.70016

Liping Xue, Min Hu, Yadi Li, Qin Zhu, Guanglong Zhou, Xiaofan Zhang, Yuan Zhou, Jieying Zhang, Peng Ding

{"title":"Ginsenoside Rg1 inhibits angiogenesis in diabetic retinopathy through the miR-100-3p/FBXW7/c-MYC molecular axis.","authors":"Liping Xue, Min Hu, Yadi Li, Qin Zhu, Guanglong Zhou, Xiaofan Zhang, Yuan Zhou, Jieying Zhang, Peng Ding","doi":"10.1111/jdi.70016","DOIUrl":"https://doi.org/10.1111/jdi.70016","url":null,"abstract":"Aims/introduction: Ginsenoside Rg1 is an active ingredient found mainly in ginseng that has a variety of pharmacological effects, such as hypoglycemic, antioxidant, and anti-inflammatory effects, and it inhibits vascular formation. In this study, we explored the effect of ginsenoside Rg1 on angiogenesis in diabetic retinopathy (DR) on the basis of its ability to inhibit angiogenesis and the specific molecular mechanism involved.Materials and methods: We induced an in vivo model of diabetes by injection of 55 mg/kg streptozotocin (STZ) into the abdominal cavity of SD rats daily for 3 days. Moreover, human retinal microvascular endothelial cells (HRMECs) were treated with 30 mmol/L glucose for 24 h to construct a high-glucose (HG) cell model in vitro. The expression of related genes and proteins was detected by RT-qPCR and Western blotting. HRMECs and retinal damage were evaluated by CCK-8, scratch, tube formation assays, and HE staining.Results: In this study, Rg1 inhibited HG-induced angiogenesis of HRMECs and inhibited STZ-induced vascular leakage and capillary degeneration in vivo, alleviating the progression of DR. Mechanistically, Rg1 upregulated the expression of FBXW7 by inhibiting miR-100-3p, thereby promoting the ubiquitination and degradation of c-MYC, inhibiting HG-induced HRMECs proliferation, migration, invasion, and angiogenesis, and improving the development of DR.Conclusions: Overall, our study demonstrates that ginsenoside Rg1 can inhibit DR angiogenesis via the miR-100-3p/FBXW7/c-MYC molecular axis. These findings provide a novel idea for the treatment of DR and provide an experimental basis for further research on the application of Rg1 in the treatment of DR.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of biliverdin reductase-A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-03-02 DOI: 10.1111/jdi.70020

Li Shen, Xiaole Wei, Nan Wang, Haorui Lv, Jing Huang, Xiaoyan Zhou, Aifang Cheng, Changjiang Ying

{"title":"Predictive value of biliverdin reductase-A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes.","authors":"Li Shen, Xiaole Wei, Nan Wang, Haorui Lv, Jing Huang, Xiaoyan Zhou, Aifang Cheng, Changjiang Ying","doi":"10.1111/jdi.70020","DOIUrl":"https://doi.org/10.1111/jdi.70020","url":null,"abstract":"Aims/introduction: To investigate the predictive value of the biliverdin reductase-A (BVR-A) and the homeostasis model assessment for insulin resistance (HOMA-IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model.Materials and methods: This study included 140 patients with type 2 diabetes mellitus. Based on Montreal Cognitive Assessment (MoCA) scores, participants were categorized into the normal cognitive function (T2DM-NCF) group (65 cases) and the mild cognitive impairment (T2DM-MCI) group (75 cases). Multivariate logistic regression analysis was performed to identify the factors associated with MCI in patients with type 2 diabetes mellitus. A nomogram prediction model was developed using R software for the selected factors, and its predictability and accuracy were verified.Results: Compared with the T2DM-NCF group, subjects with MCI were older, had a longer duration of diabetes, higher HOMA-IR, lower BVR-A, lower cognitive scores, and lower education levels (all P < 0.05). Multivariate logistic regression analysis showed that duration of diabetes (OR = 1.407, 95% CI: 1.163-1.701), HOMA-IR (OR = 1.741, 95% CI: 1.197-2.53), and BVR-A (OR = 0.528, 95% CI: 0.392-0.712) were significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The C-index of the nomogram was 0.863 (95% CI: 0.752-0.937).Conclusions: Our findings suggest that BVR-A and HOMA-IR are significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The nomogram incorporating BVR-A and HOMA-IR aids in predicting the risk of developing MCI in these patients.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of brachial-ankle pulse wave velocity with subclinical diabetic peripheral neuropathy in patients with type 2 diabetes mellitus. 肱踝关节脉搏波速度与 2 型糖尿病患者亚临床糖尿病周围神经病变的关系。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-28 DOI: 10.1111/jdi.70008

Yue Wang, Ping Liu, Chang Shang, Yahui Wang, Mengfei Yuan, Guozhen Zhao, Luying Sun

{"title":"Association of brachial-ankle pulse wave velocity with subclinical diabetic peripheral neuropathy in patients with type 2 diabetes mellitus.","authors":"Yue Wang, Ping Liu, Chang Shang, Yahui Wang, Mengfei Yuan, Guozhen Zhao, Luying Sun","doi":"10.1111/jdi.70008","DOIUrl":"https://doi.org/10.1111/jdi.70008","url":null,"abstract":"Aim: Subclinical diabetic peripheral neuropathy (sDPN) in patients with type 2 diabetes mellitus is insidious, but has been complicated with neurological damage. The aim of this study was to investigate the association between brachial-ankle pulse wave velocity (baPWV) and sDPN in patients with type 2 diabetes mellitus, and to provide reference for clinical prevention and treatment of sDPN.Materials and methods: From November 2021 to May 2024, a total of 711 type 2 diabetes mellitus patients without symptoms and signs of peripheral nerve damage were recruited. According to whether the nerve conduction velocity (NCV) was abnormal or not, they were divided into the sDPN group and the non-diabetic peripheral neuropathy (non-DPN) group. Logistic regression model, restricted cubic spline (RCS) analysis and subgroup analysis were used to evaluate the correlation between baPWV and sDPN.Results: A total of 204 (28.69%) of the 711 participants were diagnosed with sDPN. Both amplitude and conduction velocity were negatively correlated with baPWV. In the fully adjusted model, elevated baPWV levels were significantly associated with an increased sDPN risk, with odds ratio (OR) = 1.084, 95% confidence interval (CI): (1.023, 1.148), P = 0.006. RCS showed a linear association between baPWV and sDPN. Subgroup analysis further confirmed that the positive association between baPWV and sDPN was consistent and robust across groups.Conclusions: Our study indicates a pronounced link between higher baPWV and increased risk of sDPN among type 2 diabetes mellitus patients without symptoms and signs of peripheral nerve damage. These findings underscore the importance of baPWV for early identification of sDPN.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author's Reply to Letter to Editor in response to the article "Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022".

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-28 DOI: 10.1111/jdi.70013

Mushood Ahmed, Aimen Shafiq, Raheel Ahmed

引用次数: 0

Awareness of the risk factors and interventions for dementia among outpatients with diabetes.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-28 DOI: 10.1111/jdi.14393

Masashi Honda, Masahiro Sugawara, Nobuichi Kuribayashi, Yoshitaka Aiso, Shinichi Ito, Kageki Ito, Kazuo Kanno, Yasuhisa Someya, Tatsumi Moriya

{"title":"Awareness of the risk factors and interventions for dementia among outpatients with diabetes.","authors":"Masashi Honda, Masahiro Sugawara, Nobuichi Kuribayashi, Yoshitaka Aiso, Shinichi Ito, Kageki Ito, Kazuo Kanno, Yasuhisa Someya, Tatsumi Moriya","doi":"10.1111/jdi.14393","DOIUrl":"https://doi.org/10.1111/jdi.14393","url":null,"abstract":"Aims/introduction: As the prevalence of diabetes increases with age, the number of elderly patients with diabetes in Japan, a super-aged society, continues to increase. We conducted a survey to investigate the extent to which outpatients with diabetes recognize dementia as a complication of diabetes.Materials and methods: A questionnaire was distributed among 777 patients with diabetes to investigate their awareness of dementia and its risk factors. Among these, the Mini-Mental State Examination was also administered to patients over 65 years of age who wished to undergo a cognitive function test among those who participated in the questionnaire survey to examine the factors leading to a decline in cognitive function.Results: 458 patients selected poor blood glucose control and 176 selected hypoglycemia as the condition that rendered patients susceptible to dementia. Regarding the risk factors for suspected cognitive decline, the risk increased in the following order: old age; lack of knowledge about dementia; and treatment with diet/exercise, oral hypoglycemic agents/Glucagon-like peptide-1, and insulin. Regarding the relationship between cognitive decline and blood glucose control, the risk of suspected cognitive decline increased in the following order: within the standard value, above and below the standard values, in terms of the level of glycated hemoglobin set in \"Blood Glucose Control Target for Elderly Diabetes\" defined by the Japan Geriatrics Society and the Japan Diabetes Society.Conclusions: When examining and treating diabetes, it may be pertinent to instruct older adults on target HbA1c levels based on their condition.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of administration and withdrawal of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single-arm study (RESTORE-nephropathy study).

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-27 DOI: 10.1111/jdi.70018

Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi

{"title":"Effect of administration and withdrawal of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, on renal protection in individuals with type 2 diabetes mellitus and diabetic nephropathy: A multicenter, single-arm study (RESTORE-nephropathy study).","authors":"Ayako Shigeta, Masami Tanaka, Shu Meguro, Jiro Morimoto, Takatoshi Imai, Akira Yamauchi, Yasuhiko Kanazawa, Toshihide Kawai, Koichiro Azuma, Satoru Yamada, Sho Endo, Hiroshi Itoh, Kaori Hayashi","doi":"10.1111/jdi.70018","DOIUrl":"https://doi.org/10.1111/jdi.70018","url":null,"abstract":"Aims/introduction: The mechanisms of the renoprotective effects of sodium-glucose cotransporter 2 inhibitors are unknown. This study aimed to explore the effect and mechanism of tofogliflozin on urinary albumin by administration, withdrawal, and re-administration.Materials and methods: Individuals with type 2 diabetes mellitus and stage 2 or 3 diabetic nephropathy were enrolled. Tofogliflozin was administered for 24 weeks, withdrawn for 12 weeks (withdrawal period), and re-administered for 24 weeks. The primary endpoint was the change in urinary albumin/creatinine ratio (UACR). The secondary endpoints included hemoglobin A1c (HbA1c), hepatic biomarkers, lipid profiles, physical examinations, and blood counts.Results: A total of 47 individuals were enrolled. UACR significantly decreased throughout the observation period. It also significantly decreased, increased, and again decreased during the period of the 1st administration, withdrawal, and re-administration, respectively. HbA1c, body weight, waist circumference, and systolic blood pressure also showed the same tendency. Aspartate aminotransferase and alanine aminotransferase significantly decreased throughout the observation period, but did not increase during the withdrawal period.Conclusions: Urinary albumin improved during the administration of tofogliflozin and worsened during its withdrawal, suggesting the reversibility of its renoprotective effect. The administration of tofogliflozin should be continued to avoid the reversal of glycemic control, renoprotective effects, and other beneficial effects.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Executive function deficits in adults with childhood-onset type 1 diabetes mellitus: Evidence from Wisconsin card sorting test performance. 儿童期发病的 1 型糖尿病成人的执行功能缺陷：威斯康星卡片分类测试成绩的证据。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-26 DOI: 10.1111/jdi.70007

Jing He, Wenjing Zou, Hongyu Du, Songzhuzi Liu, Xia Li, Zhiguang Zhou, Xiongzhao Zhu

{"title":"Executive function deficits in adults with childhood-onset type 1 diabetes mellitus: Evidence from Wisconsin card sorting test performance.","authors":"Jing He, Wenjing Zou, Hongyu Du, Songzhuzi Liu, Xia Li, Zhiguang Zhou, Xiongzhao Zhu","doi":"10.1111/jdi.70007","DOIUrl":"https://doi.org/10.1111/jdi.70007","url":null,"abstract":"Background: Executive functions (EFs) are important for the Type 1 diabetes mellitus (T1DM) self-care perspective. This study aimed to investigate whether patients with T1DM have poorer EFs than healthy controls (HCs) and whether there are differences in EFs between childhood-onset and adult-onset T1DM.Methods: This study included 94, 110, and 100 participants with childhood-onset and adult-onset T1DM and HCs, respectively. All participants completed the Wisconsin Card Sorting Test to assess EFs. The Chinese version of the WAIS and BDI-II were performed to determine IQ and emotion in all participants.Results: The childhood-onset group made lower scores of WCST total errors (P = 0.015), perseverative errors (P = 0.038) than the HC group, and the adult-onset group made lower scores of WCST total errors (P = 0.025) than the HC group. In the diabetes group, after controlling diabetes duration, the childhood-onset group made significantly higher scores of WCST total errors (P = 0.040), perseverative errors (P = 0.038), and non-perseverative errors (P = 0.013). In the childhood-onset group, perseverative errors were significantly associated with duration of T1DM (β = -0.24, t = -2.34, P = 0.021), and the history of severe hypoglycemia affects the non-perseverative errors(β = -0.26, t = -2.55, P = 0.013).Conclusions: T1DM is associated with EF decrements, and there are differences in EFs between childhood-onset and adult-onset T1DM. These findings indicate that we should consider detecting and intervening in EF deficits in the T1DM population according to the age of onset.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-02-24 DOI: 10.1111/jdi.70011

Xiang Lei, Xiu Wang, Xinai Zhang

{"title":"YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy.","authors":"Xiang Lei, Xiu Wang, Xinai Zhang","doi":"10.1111/jdi.70011","DOIUrl":"https://doi.org/10.1111/jdi.70011","url":null,"abstract":"Aims/introduction: Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression. Therefore, we aimed to investigate the relationship between PHGDH, serine synthesis, and DR and their underlying molecular mechanisms.Method: Differentially expressed genes in DR were screened using bioinformatics tools. DR mice were induced, and retinal histopathology was observed in mice. Overexpression of PHGDH was induced in the DR mice to measure l-serine, ROS, and MDA content in the retinas of DR mice. ARPE-19 cells were transfected with overexpression of PHGDH and exposed to high glucose to induce a DR in vitro model, and cell viability and apoptosis assays, serine content, and oxidative stress factor measurement were conducted. The transcriptional regulation of PHGDH by YY2 was explored by ChIP and dual-luciferase reporter assays. Finally, the combined role of YY2 and PHGDH in regulating serine synthesis, oxidative stress, and ferroptosis was investigated.Results: PHGDH expression was reduced in DR mice, and overexpression of PHGDH alleviated DR progression by promoting serine synthesis and attenuating oxidative stress. YY2 bound to the promoter of PHGDH and mediated its transcriptional repression. YY2-mediated transcriptional repression of PHGDH caused disturbances in serine synthesis, leading to oxidative stress-triggered ferroptosis.Conclusions: Our data prove that YY2 plays a vital role in modulating PHGDH expression, impairing serine synthesis, and expediting oxidative stress and ferroptosis.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0