Journal of Diabetes Investigation最新文献_第3页

Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study. 瘦体重指数与糖尿病发病风险：一项全国流行病学队列研究。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-24 DOI: 10.1111/jdi.70102

Kazuki Aoyama, Hidehiro Kaneko, Tatsuhiko Azegami, Akira Okada, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi

{"title":"Lean body mass index and the risk of diabetes onset: A nationwide epidemiological cohort study.","authors":"Kazuki Aoyama, Hidehiro Kaneko, Tatsuhiko Azegami, Akira Okada, Yuta Suzuki, Shu Meguro, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Norihiko Takeda, Hideo Yasunaga, Kaori Hayashi","doi":"10.1111/jdi.70102","DOIUrl":"https://doi.org/10.1111/jdi.70102","url":null,"abstract":"Aims/introduction: Diabetes causes microvascular complications and cardiovascular diseases, and identifying its risk factors is a critical issue. Muscle is a primary target organ of insulin; however, previous studies on the relationship between lean body mass and the risk of developing diabetes have reported inconsistent findings. This study aimed to evaluate the association between the predicted lean body mass index (LBMI), which can be easily calculated in daily clinical practice, and the risk of developing diabetes.Materials and methods: This retrospective study analyzed a large scale real-world database to investigate the relationship between LBMI and diabetes risk in both men and women. The incidence of diabetes was determined using ICD-10 codes from an administrative claims database, and Cox regression and cubic spline models were employed.Results: The median age (interquartile range) was 59 (45-67) years for men and 63 (50-68) for women. Among 581,176 men and 721,605 women, a lower LBMI was associated with an increased risk of diabetes onset in both men and women (hazard ratio [95% confidence interval] (Men): Q1, 1.27 [1.23-1.32]; Q2, 1.07 [1.04-1.10]; Q3, 1.02 [0.99-1.04]; Q4. 1 [reference value], HR [95% CI] (Women): Q1, 1.10 [1.06-1.15]; Q2, 1.00 [0.97-1.03]; Q3, 0.99 [0.96-1.02]; Q4. 1 [reference value]). The restricted cubic spline regression model revealed that the risk of diabetes onset increased as LBMI decreased in both men and women.Conclusions: We demonstrated that a lower LBMI was associated with a higher risk of diabetes onset in both men and women.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of the intensity of physical performance and sedentary time with uric acid in patients with type 2 diabetes. 2型糖尿病患者运动强度和久坐时间与尿酸的关系

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-18 DOI: 10.1111/jdi.70106

Jie Li, Ertao Zhang, Zhao Dong, Yan Liu

{"title":"Relationship of the intensity of physical performance and sedentary time with uric acid in patients with type 2 diabetes.","authors":"Jie Li, Ertao Zhang, Zhao Dong, Yan Liu","doi":"10.1111/jdi.70106","DOIUrl":"https://doi.org/10.1111/jdi.70106","url":null,"abstract":"Objective: High uric acid (UA) facilitates diabetes progression and is responsible for developing other diseases, such as cardiovascular disease and renal disease. Lifestyle modifications could lower UA level, but relevant evidence is required in patients with type 2 diabetes. This study intended to explore the influence of different physical activities and sitting time on UA level in patients with type 2 diabetes.Methods: Data on UA level, physical performance, and sitting time from 1892 patients with type 2 diabetes were retrospectively obtained from the Third People's Hospital of Datong, a subcenter of the Metabolic Management Center (MMC) Central database.Results: There were 15.8%, 29.7%, 29.5%, and 25.0% of patients with inactive, mild, moderate, and vigorous intensity of physical activity. UA level presented a U-shaped distribution among patients with different intensities of physical activity, with the lowest in patients with mild intensity of physical activity and the highest in patients with vigorous intensity of physical activity (P = 0.007). There were 58.1% and 41.9% of patients with a sitting time of ≤30 h/week and >30 h/week. UA level was lower in patients with sitting time ≤30 h/week than those with sitting time > 30 h/week (P = 0.014). The above findings were confirmed by multivariate linear regression models.Conclusions: Mild intensity of physical activity and sitting time ≤ 30 h/week are recommended for reducing UA level in patients with type 2 diabetes.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of insulin resistance on post-stroke depression and outcomes in diabetes. 胰岛素抵抗对卒中后抑郁和糖尿病预后的影响。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-18 DOI: 10.1111/jdi.70097

Lifei Tan, Yan Li, Ming Tan, Jing Gong, Jinbiao Zhang

{"title":"Impact of insulin resistance on post-stroke depression and outcomes in diabetes.","authors":"Lifei Tan, Yan Li, Ming Tan, Jing Gong, Jinbiao Zhang","doi":"10.1111/jdi.70097","DOIUrl":"https://doi.org/10.1111/jdi.70097","url":null,"abstract":"Aims: This study aimed to examine the association between insulin resistance (IR) and post-stroke depression (PSD) occurrence in diabetic patients, providing novel insights for PSD prevention and treatment strategies.Materials and methods: Clinical data from 124 patients with acute cerebral infarction and diabetes mellitus were retrospectively analyzed. Based on the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), participants were stratified into two groups: an IR group (HOMA-IR > 2.69, n = 96) and a control group (HOMA-IR ≤ 2.69, n = 28). The occurrence of PSD was compared between the two groups by unadjusted analysis and inverse probability of treatment weighting (IPTW), and the correlation between HOMA-IR scores and PSD was analyzed by multivariate logistic regression.Results: At 3-month follow-up, the IR group exhibited significantly higher Hamilton Depression Scale (HAMD) scores (median 8 vs 6, P = 0.029) and a 3.28-fold increased PSD risk (OR = 3.28, 95% CI: 1.37-7.88, P = 0.006). After adjusting for baseline confounders using IPTW, the IR group maintained elevated PSD risk (adjusted OR = 2.64, P = 0.035). Multivariate analysis confirmed HOMA-IR as an independent PSD predictor (OR = 1.755, 95% CI: 1.360-2.263, P < 0.001), with ROC analysis demonstrating moderate predictive accuracy (AUC = 0.76, 51.4% sensitivity, 94.2% specificity at cutoff 5.2).Conclusions: Elevated HOMA-IR levels in diabetic patients with acute cerebral infarction are significantly associated with increased PSD incidence.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor in response to "Predictive value of biliverdin reductase-A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes". 针对“胆绿素还原酶- a和稳态模型评估胰岛素抵抗对2型糖尿病患者轻度认知障碍的预测价值”致编辑的回复信。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-13 DOI: 10.1111/jdi.70104

Jie Chen, Li Zhou

引用次数: 0

Comment on "Concomitant use of metformin and proton pump inhibitors increases vitamin B12 deficiency risk in type 2 diabetes". 评论“同时使用二甲双胍和质子泵抑制剂会增加2型糖尿病患者维生素B12缺乏的风险”。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-13 DOI: 10.1111/jdi.70103

Kuan-Fu Liao, Shih-Wei Lai

引用次数: 0

Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells. 依米霉素改善永活成年小鼠雪旺IMS32细胞高血糖和低血糖诱导的细胞死亡和线粒体功能障碍。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-13 DOI: 10.1111/jdi.70092

Ayako Kato, Wataru Nihei, Hideji Yako, Yasuaki Tatsumi, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato

{"title":"Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells.","authors":"Ayako Kato, Wataru Nihei, Hideji Yako, Yasuaki Tatsumi, Tatsuhito Himeno, Masaki Kondo, Yoshiro Kato, Jiro Nakamura, Hideki Kamiya, Kazunori Sango, Koichi Kato","doi":"10.1111/jdi.70092","DOIUrl":"https://doi.org/10.1111/jdi.70092","url":null,"abstract":"Aims/introduction: Imeglimin, a novel oral antidiabetic drug, enhances glucose-stimulated insulin secretion, improves insulin sensitivity, and reduces mitochondrial reactive oxygen species (ROS) generation. Diabetic neuropathy is driven by oxidative stress caused by hyperglycemia, with mitochondrial ROS overproduction playing a central role. Hypoglycemia also contributes to oxidative stress. This study evaluates the effects of imeglimin on Schwann cells under high- and low-glucose conditions.Materials and methods: We used IMS32 cells, an immortalized mouse Schwann cell line, to investigate cell survival and mitochondrial function under normal, high-, and low-glucose conditions. Assessments included mitochondrial oxidative stress, cytochrome c release, mitochondrial membrane potential, oxygen consumption rate (OCR), Complex I activity, and ATP synthesis.Results: High- and low-glucose conditions caused cell death, elevated mitochondrial ROS, triggered cytochrome c release, disrupted mitochondrial membrane potential, and increased OCR and Complex I activity, while suppressing ATP synthesis. Imeglimin treatment mitigated cell death, reduced oxidative stress, restored mitochondrial membrane potential, normalized OCR and Complex I activity, and improved ATP synthesis under both glucose conditions.Conclusions: Fluctuations in glucose levels impair mitochondrial function in Schwann cells, contributing to peripheral nerve damage in diabetic neuropathy. Imeglimin demonstrated protective effects by alleviating mitochondrial dysfunction and preventing apoptosis signaling. These findings suggest the potential application of imeglimin in preventing and treating diabetic neuropathy; however, the clinical implications require further investigation.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of lean metabolic dysfunction-associated steatotic liver disease with carotid plaque progression in patients with type 2 diabetes mellitus. 2型糖尿病患者瘦代谢功能障碍相关脂肪变性肝病与颈动脉斑块进展的关系

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-12 DOI: 10.1111/jdi.70050

Youngjoon Kim, Yongin Cho, Yong-Ho Lee, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim

{"title":"Association of lean metabolic dysfunction-associated steatotic liver disease with carotid plaque progression in patients with type 2 diabetes mellitus.","authors":"Youngjoon Kim, Yongin Cho, Yong-Ho Lee, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim","doi":"10.1111/jdi.70050","DOIUrl":"https://doi.org/10.1111/jdi.70050","url":null,"abstract":"Introduction: We aimed to investigate whether lean metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus.Materials and methods: We investigated 828 patients with type 2 diabetes mellitus who underwent baseline abdominal and carotid artery ultrasonography, followed by repeat carotid ultrasonography after 6-8 years. MASLD was confirmed by abdominal ultrasonography, and lean body mass was defined as a body mass index <23 kg/m2. Carotid atherosclerosis progression was defined as the appearance of new carotid plaque lesions on repeat ultrasonography. The association between lean MASLD, non-lean MASLD, and the progression of carotid atherosclerosis was investigated.Results: Among the 828 patients, 57 (6.9%), 197 (23.8%), 397 (47.9%), and 177 (21.4%) were classified as lean MASLD, lean without MASLD, non-lean MASLD, and non-lean without MASLD, respectively. After 6-8 years, both lean MASLD (adjusted odds ratio [aOR], 2.57; P = 0.005) and non-lean MASLD (aOR, 1.59; P = 0.029) had a higher risk of atherosclerosis progression than controls (lean without MASLD). No significant difference was observed in the risk of atherosclerosis progression between the lean and non-lean MASLD groups.Discussion: In patients with type 2 diabetes mellitus, both lean and non-lean MASLD were significantly associated with an increased risk of carotid atherosclerosis progression compared to those who were lean without MASLD. This suggests that evaluation of liver steatosis in patients with type 2 diabetes mellitus, regardless of body weight, may help identify individuals at high risk for carotid atherosclerosis progression.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating cell-free mitochondrial DNA in diabetes mellitus: Current insights and unexplored frontiers. 糖尿病循环无细胞线粒体DNA：当前的见解和未开发的前沿。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-12 DOI: 10.1111/jdi.70071

Mohammadreza Akbari, Fatemeh Masjedi, Mohammad Nekooeian, Mahintaj Dara, Jamshid Roozbeh

{"title":"Circulating cell-free mitochondrial DNA in diabetes mellitus: Current insights and unexplored frontiers.","authors":"Mohammadreza Akbari, Fatemeh Masjedi, Mohammad Nekooeian, Mahintaj Dara, Jamshid Roozbeh","doi":"10.1111/jdi.70071","DOIUrl":"https://doi.org/10.1111/jdi.70071","url":null,"abstract":"The role and significance of circulating cell-free mitochondrial DNA (ccf-mtDNA)-small fragments of mitochondrial DNA present in plasma-are becoming increasingly clear in various diseases. The release of mtDNA into the plasma results from mitochondrial dysfunction, cell death, and NETosis, all of which are elevated in diabetes and its complications. Due to its resemblance to pathogenic DNA, mitochondrial DNA can activate several immunological pathways, leading to inflammation-a key factor in diabetes and its complications. Studies reveal a significant overlap between the immunological pathways involved in diabetes and those triggered by ccf-mtDNA. Thus, ccf-mtDNA may play a crucial role in the pathophysiology of diabetes and its complications, making it a potential diagnostic, prognostic, and therapeutic target. This review aims to summarize research findings on the role of ccf-mtDNA in diabetes, including gestational diabetes and related complications. Most studies have focused on type 2 diabetes, whereas research on ccf-mtDNA in other forms, including type 1 diabetes, remains limited. By synthesizing these insights, we seek to clarify the role of ccf-mtDNA in diabetes and identify gaps for future research.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METTL3/YTHDF3 m⁶A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1. METTL3/YTHDF3 m6A轴通过稳定TfR1促进糖尿病肾病铁下垂。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-10 DOI: 10.1111/jdi.70094

Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li

{"title":"METTL3/YTHDF3 m6A axis promotes ferroptosis in diabetic kidney disease by stabilizing TfR1.","authors":"Jinmei Zhang, Xiaoping Zhou, Bin Wang, Yan Yin, Daihao Wei, Kun Li","doi":"10.1111/jdi.70094","DOIUrl":"https://doi.org/10.1111/jdi.70094","url":null,"abstract":"Objective: Diabetic kidney disease (DKD) is a common complication of diabetes. N6-Methyladenosine (m6A) modification is a widely studied epigenetic mechanism. Methyltransferase-like (METTL) 3 is a well-studied methyltransferase. This study aimed to investigate the role of METTL3 in DKD and the underlying mechanism.Methods: Thirty-five DKD patients and 28 control volunteers were recruited. Animal and cell DKD models were established. QRT-PCR and Western blot were performed to analyze the expression of METTL3 and fibrosis-related indicators. Cell viability and proliferation were assessed via a cell counting kit-8 and colony formation assays. Ferrous iron (Fe2+), malonaldehyde (MDA), and glutathione (GSH) contents were measured by commercial kits. The interaction between METTL3/YTH N6-methyladenosine RNA binding protein (YTHDF)3 and transferrin receptor-1 (TfR1) was examined through RNA immunoprecipitation and dual-luciferase reporter assays.Results: Results showed that METTL3-mediated m6A modification was elevated in kidney tissues of DKD patients and in high glucose (HG)-treated human renal mesangial cells (HRMCs). Besides, HG-treated HRMCs showed increased ferroptosis. In addition, METTL3 inhibition increased cell proliferation and inhibited ferroptosis in HRMCs. Mechanically, the METTL3/YTHDF3 m6A axis enhanced the stability of TfR1 mRNA. Moreover, YTHDF3 inhibition increased cell proliferation and inhibited ferroptosis in HRMCs. Finally, in vivo study results indicated that METTL3 deficiency inhibited ferroptosis and improved pathological damages.Conclusions: In summary, METTL3/YTHDF3 m6A axis promoted ferroptosis in DKD by stabilizing TfR1, which could provide a reference for DKD treatment.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leptin promoter G2548A variant, elevated plasma leptin levels, and increased risk of Type 2 diabetes with CAD in Iranian patients: A genetic association study. 伊朗患者瘦素启动子G2548A变异、血浆瘦素水平升高和2型糖尿病合并冠心病风险增加：一项遗传关联研究

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-06-10 DOI: 10.1111/jdi.70077

Leila Saremi, Nazanin Ahmadi, Fatemeh Feizy, Shirin Lotfipanah, Mohammad Ebrahim Ghaffari, Zohreh Saltanatpour

{"title":"Leptin promoter G2548A variant, elevated plasma leptin levels, and increased risk of Type 2 diabetes with CAD in Iranian patients: A genetic association study.","authors":"Leila Saremi, Nazanin Ahmadi, Fatemeh Feizy, Shirin Lotfipanah, Mohammad Ebrahim Ghaffari, Zohreh Saltanatpour","doi":"10.1111/jdi.70077","DOIUrl":"https://doi.org/10.1111/jdi.70077","url":null,"abstract":"Background: Type 2 diabetes mellitus (T2DM) is a significant risk factor for coronary artery disease (CAD). Leptin polymorphism is known to be associated with obesity and Type 2 diabetes mellitus. This study aimed to investigate the possible links between a specific leptin polymorphism (LEP 2548G/A) and plasma leptin level with the risk of Type 2 diabetes mellitus patients with CAD in the Iranian population for the first time.Methods and results: A total of 150 patients with Type 2 diabetes mellitus and CAD were included in the study, along with 150 nondiabetic controls. Blood samples were collected from participants. Biochemical analysis and genotyping were done using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The plasma leptin level was higher in females in the case group. There was a positive correlation between females and obese diabetic subjects (P < 0.001). Regarding the single-nucleotide polymorphism in the leptin gene promoter, we found that the variant genotypes AA and GG were associated with a twofold (OR = 2.09, P = 0.006) and fourfold (OR = 4.2, P = 0.017) increased risk of Type 2 diabetes mellitus patients with CAD, respectively. The GG genotype was also associated with obesity and higher plasma leptin level in the case group (OR = 4.92, P < 0.001).Conclusions: Leptin G2548A and plasma leptin levels may contribute to Type 2 diabetes with CAD in the Iranian population.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0