Journal of Diabetes Investigation最新文献_第4页

The roles of output clock genes in regulating glucose metabolism. 输出时钟基因在调节葡萄糖代谢中的作用。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-10-03 DOI: 10.1111/jdi.14295

Akihiko Taguchi, Yasuharu Ohta, Yuko Nagao, Yukio Tanizawa

引用次数: 0

Low-carbohydrate diets in East Asians with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. 东亚 2 型糖尿病患者的低碳水化合物饮食：随机对照试验的系统回顾和荟萃分析。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-10-03 DOI: 10.1111/jdi.14326

Junya Hironaka, Masahide Hamaguchi, Takahiro Ichikawa, Hanako Nakajima, Takuro Okamura, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Erina Joo, Kenichiro Shide, Michiaki Fukui

{"title":"Low-carbohydrate diets in East Asians with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.","authors":"Junya Hironaka, Masahide Hamaguchi, Takahiro Ichikawa, Hanako Nakajima, Takuro Okamura, Saori Majima, Takafumi Senmaru, Hiroshi Okada, Emi Ushigome, Naoko Nakanishi, Erina Joo, Kenichiro Shide, Michiaki Fukui","doi":"10.1111/jdi.14326","DOIUrl":"10.1111/jdi.14326","url":null,"abstract":"Aims: Despite the reported success of low-carbohydrate diets in improving glycemic control in the Western countries, no studies have investigated the effects of such diets in Asians. We aimed to conduct a systematic review and meta-analysis of randomized controlled trials to examine the effects of low-carbohydrate diets on glycemic control in East Asian adults.Materials and methods: We systematically searched the PubMed, Cochrane Library, and Embase databases from inception to June 28, 2023, to identify randomized controlled trials examining the efficacy of low-carbohydrate diets in patients with type 2 diabetes (PROSPERO number CRD 42023453007). The primary outcome was the difference in glycated hemoglobin levels between the low-carbohydrate diet and control groups. The secondary outcome was the difference in body mass index, fasting blood glucose level, blood pressure, and lipid profile.Results: Six randomized controlled trials met the eligibility criteria. The study duration ranged from 3 to 18 months, with five studies conducted within 6 months. The results showed that low-carbohydrate diets were more beneficial in lowering glycated hemoglobin levels and body mass index than control diets. The risk of bias for the six studies was minimal for two and moderate for four. The heterogeneity among the studies was low.Conclusions: Low-carbohydrate diets improved glycated hemoglobin levels and body mass index in East Asians compared with control diets. Therefore, carbohydrate restriction may be effective for glycemic management in East Asians with type 2 diabetes for at least 6 months.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncoding RNAs and diabetic kidney disease. 非编码 RNA 与糖尿病肾病

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-10-03 DOI: 10.1111/jdi.14331

Jun Wada

引用次数: 0

Regulation of glucose and energy metabolism through actions of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. 通过胰高血糖素样肽-1 和葡萄糖依赖性促胰岛素多肽的作用调节葡萄糖和能量代谢。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-30 DOI: 10.1111/jdi.14305

Yasuo Zenimaru, Norio Harada

引用次数: 0

Neonatal diabetes mellitus around the world: Update 2024. 全球新生儿糖尿病：2024 年更新。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-30 DOI: 10.1111/jdi.14312

Fabrizio Barbetti, Asma Deeb, Shigeru Suzuki

{"title":"Neonatal diabetes mellitus around the world: Update 2024.","authors":"Fabrizio Barbetti, Asma Deeb, Shigeru Suzuki","doi":"10.1111/jdi.14312","DOIUrl":"https://doi.org/10.1111/jdi.14312","url":null,"abstract":"Neonatal diabetes mellitus (NDM), defined as diabetes with an onset during the first 6 months of life, is a rare form of monogenic diabetes. The initial publications on this condition began appearing in the second half of the 1990s and quite surprisingly, the search for new NDM genes is still ongoing with great vigor. Between 2018 and early 2024, six brand new NDM-genes have been discovered (CNOT1, FICD, ONECUT1, PDIA6, YIPF5, ZNF808) and three genes known to cause different diseases were identified as NDM-genes (EIF2B1, NARS2, KCNMA1). In addition, NDM cases carrying mutations in three other genes known to give rise to diabetes during childhood have been also identified (AGPAT2, BSCL2, PIK3R1). As a consequence, the list of NDM genes now exceeds 40. This genetic heterogeneity translates into many different mechanism(s) of disease that are being investigated with state-of-the-art methodologies, such as induced pluripotent stem cells (iPSC) and human embryonic stem cells (hESC) manipulated with the CRISPR technique of genome editing. This diversity in genetic causes and the pathophysiology of diabetes dictate the need for a variety of therapeutic approaches. The aim of this paper is to provide an overview on recent achievements in all aspects of this area of research.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking extent of return to fasting state after oral glucose tolerance test to future risk of prediabetes and type 2 diabetes: Insights from the TLGS. 将口服葡萄糖耐量试验后恢复到空腹状态的程度与未来罹患糖尿病前期和 2 型糖尿病的风险联系起来：来自 TLGS 的启示。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-29 DOI: 10.1111/jdi.14308

Soroush Masrouri, Seyed Saeed Tamehri Zadeh, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh

{"title":"Linking extent of return to fasting state after oral glucose tolerance test to future risk of prediabetes and type 2 diabetes: Insights from the TLGS.","authors":"Soroush Masrouri, Seyed Saeed Tamehri Zadeh, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh","doi":"10.1111/jdi.14308","DOIUrl":"https://doi.org/10.1111/jdi.14308","url":null,"abstract":"Aims: To assess the risk of difference between 2 h post-load plasma glucose (2 h-PG) and fasting plasma glucose (FPG) on incident prediabetes/type 2 diabetes (T2DM) among normoglycemic individuals.Methods: Among 4,971 individuals aged ≥20 years, the associations of the difference between 2 h-PG and FPG with outcomes were examined using multivariable-adjusted Cox regression analysis. Participants were categorized into three groups: a low post-load group (2 h-PG ≤ FPG, as the reference group); a high post-load group (2 h-PG > FPG and ≥75th percentile of the difference); and a medium post-load group (2 h-PG > FPG and <75th percentile of the difference), which was further categorized into three groups by equal ranges.Results: Over a median of 11.5 years of follow-up, 2,331 new cases of prediabetes/type 2 diabetes and 360 cases of type 2 diabetes occurred. Greater risks of incident prediabetes/type 2 diabetes in second (9-16 mg/dL) and third (17-24 mg/dL) medium post-load, as well as high post-load (≥25 mg/dL) categories, were found, with hazard ratios (95% confidence intervals) of 1.26 (1.11-1.44), 1.32 (1.15-1.51), and 1.69 (1.51-1.90), respectively; the issue was more prominent among women (P for interaction = 0.005). The risk of incident type 2 diabetes was also higher for these categories. After further adjustment for the homeostasis model assessment of insulin resistance, result remained essentially unchanged. Even among individuals with low normal FPG (i.e., <90 mg/dL), ≥9 mg/dL difference between 2 h-PG and FPG increased the risk of composite prediabetes/ type 2 diabetes.Conclusions: Greater levels of 2 h-PG as low as 9 mg/dL than FPG among normoglycemic individuals is a harbinger of prediabetes/type 2 diabetes development.","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142337879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maturity-onset diabetes of the young: A proposal for updated nomenclature. 青少年成熟期糖尿病：关于更新命名法的建议。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-29 DOI: 10.1111/jdi.14320

Mustafa Tosur

引用次数: 0

Commentary on "Intra-islet α-cell Gs signaling promotes glucagon release". 关于 "胰岛α细胞内 Gs 信号传导促进胰高血糖素释放 "的评论

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-26 DOI: 10.1111/jdi.14317

Tadahiro Kitamura

引用次数: 0

Clinical challenges in early pregnancy in Japan: An update on gestational diabetes. 日本孕早期的临床挑战：妊娠糖尿病的最新进展。

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-26 DOI: 10.1111/jdi.14319

Takashi Sugiyama, Maki Kawasaki, Naoko Arata

引用次数: 0

Coexistence of high visceral fat area and sarcopenia and atherosclerotic markers in older patients with diabetes: Is there an association? 老年糖尿病患者的高内脏脂肪面积与肌肉疏松症和动脉粥样硬化标志物同时存在：是否存在关联？

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2024-09-26 DOI: 10.1111/jdi.14322

Christian Saleh

引用次数: 0