Journal of Diabetes Investigation最新文献

{"title":"A pitfall in the evaluation of Sampson-estimated small dense LDL cholesterol in metabolic disorders: Is it equivalent to directly measured sdLDL-C?","authors":"Tsutomu Hirano","doi":"10.1111/jdi.70450","DOIUrl":"10.1111/jdi.70450","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effects of tofogliflozin on renal function in patients with type 2 diabetes: A retrospective multicenter study.","authors":"Natsuko Shinagawa, Hiroshi Okada, Junya Hironaka, Shinta Yamamoto, Mari Yoneda, Sayaka Kawai, Yuto Saijyo, Tomoya Katayama, Hanako Nakajima, Akio Kishi, Noriyuki Kitagawa, Naoko Nakanishi, Masahide Hamaguchi, Michiaki Fukui","doi":"10.1111/jdi.70445","DOIUrl":"10.1111/jdi.70445","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the long-term renal effects of tofogliflozin, with the shortest half-life among sodium-glucose cotransporter 2 inhibitors, in real-world clinical practice.</p><p><strong>Materials and methods: </strong>We retrospectively enrolled patients with type 2 diabetes mellitus treated at three affiliated hospitals between January 2015 and May 2024. The primary outcome was the change in estimated glomerular filtration rate from baseline to 72 months. After inverse probability of treatment weighting, linear mixed-effects models were used to compare estimated glomerular filtration rate changes between the tofogliflozin and non-tofogliflozin groups. As a sensitivity analysis, multiple imputation was performed to address missing baseline urinary albumin-to-creatinine ratio data. Secondary outcomes included estimated glomerular filtration rate slopes, changes in glycated hemoglobin and body weight at 72 months, and changes in urinary albumin-to-creatinine ratio at 48 months.</p><p><strong>Results: </strong>Among 598 participants (tofogliflozin, n = 245; non-tofogliflozin, n = 353), estimated glomerular filtration rate decline was significantly slower in the tofogliflozin group than in the non-tofogliflozin group (P < 0.001). At 72 months, the least squares mean estimated glomerular filtration rate change was -4.51 and -10.64 mL/min/1.73 m², respectively (between-group difference: 6.14 mL/min/1.73 m²). Significant between-group differences were observed in estimated glomerular filtration rate slope, glycated hemoglobin, and body weight, but not in urinary albumin-to-creatinine ratio. Renal findings were consistent in the multiple imputation sensitivity analysis.</p><p><strong>Conclusions: </strong>Real-world clinical data over 72 months suggested that tofogliflozin may slow estimated glomerular filtration rate decline.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2i use and fracture risk compared with DPP4i in patients with T2DM.","authors":"Sung-Yen Lin, Shih-Hao Huang, Ching-Han Chiang, Cheng-Jung Ho, Chung-Hwan Chen, Li-Nien Chien","doi":"10.1111/jdi.70433","DOIUrl":"10.1111/jdi.70433","url":null,"abstract":"<p><strong>Introduction: </strong>The association between sodium-glucose cotransporter-2 inhibitor (SGLT2i) use and fracture risk remains inconclusive. Most previous studies have focused on treatment-naïve patients, despite many patients in routine clinical practice initiating SGLT2i therapy after prior dipeptidyl peptidase-4 inhibitor (DPP4i) use. This study aimed to evaluate the risk of fractures associated with SGLT2i compared with dipeptidyl peptidase-4 inhibitors (DPP4i) in Taiwan.</p><p><strong>Materials and methods: </strong>This nationwide cohort study used Taiwan's National Health Insurance Research Database. Patients with T2DM initiating SGLT2i or DPP4i therapy between 2016 and 2019 were identified. Follow-up began one year after the index date to ensure adequate treatment exposure before outcome assessment. A prevalent new-user design and 1:2 propensity score matching (PSM) were applied to balance baseline characteristics. Fractures were ascertained from medical claims, and competing risk regression was used to estimate fracture risk, accounting for death as a competing event.</p><p><strong>Results: </strong>After PSM, 106,992 SGLT2i users and 213,984 DPP4i users were included with comparable baseline profiles. Over a mean follow-up of 3.5 years, the overall risk of any fracture did not differ between groups. Although SGLT2i use was associated with a significantly lower risk of hip fracture compared with DPP4i use (subdistribution hazard ratio = 0.89, 95% CI: 0.81-0.98), this association was no longer statistically significant after adjustment for multiple comparisons. Subgroup analyses yielded generally consistent findings.</p><p><strong>Conclusions: </strong>In this cohort, SGLT2i use was not associated with increased overall or major osteoporotic fracture risk vs DPP4i. The prevalent new-user design captures prior treatment histories and reflects real-world practice.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Class effect beyond glucose: Implications of the LEGEND-T2DM findings for cardiovascular outcomes.","authors":"Yuexing Liu, Weiping Jia","doi":"10.1111/jdi.70441","DOIUrl":"10.1111/jdi.70441","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Influence of Age on the Development of Stress Hyperglycemia During First-Onset ST-Elevation Myocardial Infarction\".","authors":"Muhammad Mussab Aman, Andaleeb Ikram, Najib Ullah Tokhi, Muhammad Meeran Umar, Nawazish Ali","doi":"10.1111/jdi.70443","DOIUrl":"10.1111/jdi.70443","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: Genetic predictors of GLP1 receptor agonist weight loss and side effects (Nature volume 653, pages 770-775 (2026)).","authors":"Gotaro Toda, Toshimasa Yamauchi","doi":"10.1111/jdi.70436","DOIUrl":"10.1111/jdi.70436","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteostasis in the regulation of pancreatic islet cell plasticity.","authors":"Jun Shirakawa","doi":"10.1111/jdi.70438","DOIUrl":"10.1111/jdi.70438","url":null,"abstract":"<p><p>Pancreatic islet cells continuously synthesize and secrete large quantities of peptide hormones, making them uniquely dependent on robust proteostasis networks to maintain cellular function. Traditionally, the unfolded protein response (UPR) is considered a stress-responsive pathway that protects cells from endoplasmic reticulum (ER) dysfunction or triggers apoptosis when ER stress is excessive. Here, we propose that proteostasis functions as an active physiological signaling network that governs islet cell adaptation, plasticity, and long-term homeostasis, extending beyond its conventional role in the response to cellular damage. In pancreatic β cells, glucose signaling suppresses the expression of the proapoptotic factor CHOP through both IRS2-dependent and IRS2-independent pathways, indicating that metabolic signaling directly remodels the ER stress response. In contrast, the CHOP-GADD34-eIF2α dephosphorylation axis constitutes a negative feedback mechanism that fine-tunes translational recovery and determines the balance between adaptation and cell death. Moreover, 4E-BP1-mediated inhibition of mRNA translation and modulation of mTOR signaling alleviate proteotoxic stress and promote β-cell survival under conditions of increased secretory demand. In addition to translational control, IGF2 receptor-mediated signaling has recently been implicated in the regulation of autophagy, further linking lysosomal quality control to β-cell proteostasis. Importantly, proteostasis also affects α-cell biology, where UPR signaling regulates glucagon secretion and contributes to α-to-β cell transdifferentiation, highlighting a previously unrecognized role of ER homeostasis in endocrine cell identity. Finally, recent findings indicate that progressive impairment of proteostasis is a hallmark of islet aging, integrating defects in protein folding, translation, autophagy, and stress adaptation into the pathogenesis of diabetes.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13563149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148928449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive preoperative glucose management including hospitalization is associated with lower surgical site infection in patients with diabetes: A retrospective multicenter observational study.","authors":"Yosuke Horikiri, Kazuma Ogiso, Koshi Kusumoto, Toru Kubo, Mihoko Kurano, Shigeru Kawade, Aiko Arimura, Takahisa Deguchi, Atsushi Shinnakasu, Shuji Horinouchi, Nobuyuki Koriyama, Tetsuro Kamada, Katsutaro Morino, Yoshihiko Nishio","doi":"10.1111/jdi.70435","DOIUrl":"10.1111/jdi.70435","url":null,"abstract":"<p><strong>Aims: </strong>Perioperative glycemic control reduces surgical complications, such as surgical site infection (SSI), but evidence regarding the effect of preoperative hospitalization for this purpose is limited. In Japan, some patients with diabetes are admitted for 1-2 weeks before surgery to achieve glycemic stabilization, but the clinical benefits remain uncertain. We evaluated the association between preoperative hospitalization for glycemic optimization and perioperative outcomes.</p><p><strong>Research designs and methods: </strong>We retrospectively analyzed 1,086 patients whose perioperative glycemic control was managed by diabetologists at four hospitals. Of these, 349 underwent preoperative management with hospitalization, 702 underwent preoperative management without hospitalization, and 35 underwent postoperative management only. The primary outcome was SSI, and secondary outcomes were postoperative hospital stay and antimicrobial therapy duration.</p><p><strong>Results: </strong>The incidence of SSI was 7.2, 11.1, and 20.0% in the three groups, respectively (P = 0.020). Baseline HbA1c levels were 8.6, 7.2, and 7.1%, respectively. Preoperative hospitalization was associated with lower odds of SSI (OR 0.62, 95% confidence interval 0.39-0.99, P = 0.044). Postoperative hospital stay and antimicrobial therapy were shorter in the preoperative hospitalization group. Postoperative day 1 fasting glucose showed a stronger association with SSI than preoperative glucose, while fasting glucose on the day of surgery remained clinically informative.</p><p><strong>Conclusion: </strong>Preoperative inpatient glycemic management was associated with a lower risk of SSI. Although postoperative day 1 glucose showed the strongest association with SSI, fasting glucose on the day of surgery also appeared clinically informative. These findings support coordinated glycemic optimization beginning before surgery and continuing through the early postoperative period.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148917770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fasting serum annexin A2 is associated with peripheral insulin sensitivity and may enhance glucose uptake via Src-dependent signaling.","authors":"Yuichi Ito, Tsuyoshi Okura, Mari Anno, Sonoko Kitao, Satomi Endo, Yoshinori Ichihara, Tatsuya Sawano, Junichiro Miake, Etsuko Ueta, Masahiko Kato, Shin-Ichi Taniguchi, Kazuhiro Yamamoto, Takeshi Imamura","doi":"10.1111/jdi.70431","DOIUrl":"10.1111/jdi.70431","url":null,"abstract":"<p><strong>Background and aim: </strong>Subcellular annexin A2 (ANXA2) is known to regulate membrane dynamics and GLUT4 trafficking in adipocytes; however, the role of serum ANXA2 in glucose metabolism remains unclear. We aimed to investigate the association between fasting serum ANXA2 and insulin sensitivity in humans and to examine the role of extracellular ANXA2 in glucose uptake in cultured skeletal myocytes.</p><p><strong>Methods: </strong>We conducted a clinical study in 15 non-diabetic Japanese adults who underwent hyperinsulinemic-euglycemic glucose clamp studies to assess peripheral insulin sensitivity. Fasting serum ANXA2 levels were measured and correlated with metabolic parameters. Cultured C2C12 myotubes were treated with recombinant human ANXA2 and the effects of ANXA2 on glucose uptake and insulin signaling mediators were evaluated.</p><p><strong>Results: </strong>Fasting serum ANXA2 showed a significant positive correlation with mean glucose infusion rate (mean GIR; r = 0.76, P = 0.00095). In C2C12 myotubes, both ANXA2 and insulin significantly increased glucose uptake compared with controls. ANXA2 enhanced IRS-1 and Akt phosphorylation independently of insulin, and this effect was suppressed by the Src-kinase inhibitor PP2.</p><p><strong>Conclusions: </strong>In conclusion, these results indicated that fasting serum ANXA2 is associated with peripheral insulin sensitivity in humans, and that exogenous ANXA2 may enhance glucose uptake in association with IRS-1/Akt signaling and Src-dependent pathways. Together, these findings support further evaluation of serum ANXA2 as a potential indicator reflecting peripheral insulin sensitivity.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic steatosis risk in nonobese Chinese adults with type 1 diabetes.","authors":"Zehua Jin, Jianhua Ma, Yuanyang Zhao, Yi Luo, Christopher K Rayner, Tongzhi Wu, Yong Luo","doi":"10.1111/jdi.70432","DOIUrl":"10.1111/jdi.70432","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) may be an important comorbidity in nonobese Chinese adults with type 1 diabetes (T1D). We assessed the likelihood of hepatic steatosis using the hepatic steatosis index (HSI) in 47 nonobese Chinese adults with T1D (mean age 46.9 ± 14.1 years; BMI 22.6 ± 2.5 kg/m²) and examined its association with insulin requirements. Overall, 27.7% of participants had an HSI >36, indicating a high likelihood of MASLD. Compared with those with HSI <30 (low likelihood of MASLD), individuals with HSI >36 required higher bolus and total daily insulin doses, while achieving comparable glycemic profiles. These findings demonstrate that an HSI >36 is relatively common in nonobese Chinese adults with T1D and is associated with higher insulin requirements. MASLD may therefore represent an under-recognized but clinically relevant comorbidity in nonobese Chinese adults with T1D, warranting greater attention in screening and management strategies.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}